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David Jeffries

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CD8-Positive T-Lymphocytes

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I M O Adetifa; Peter Aka; Martin Antonio; Nicholas J Battersby; Roger H Brookes; Simon D Donkor; Abdulrahman Hammond; Hannah B Ibanga; David J Jeffries; Moses D Lugos; Martin O C Ota; Patrick K Owiafe; Robert Walton; Richard A Adegbola; Philip C Hill
Interferon-γ ELISPOT as a biomarker of treatment efficacy in latent tuberculosis infection: a clinical trial.
K Touray; I M O Adetifa; Adama Jallow; J Rigby; David J Jeffries; Yin Bun Cheung; Simon A Donkor; Richard A Adegbola; Philip C Hill
Spatial analysis of tuberculosis in an urban west African setting: is there evidence of clustering?
Ifedayo M O Adetifa; Martin O C Ota; David J Jeffries; Abdulrahman Hammond; Moses D Lugos; Simon Donkor; Owiafe Patrick; Richard A Adegbola; Philip C Hill
Commercial interferon gamma release assays compared to the tuberculin skin test for diagnosis of latent Mycobacterium tuberculosis infection in childhood contacts in the Gambia.

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All Publications

2013: I M O Adetifa; Peter Aka; Martin Antonio; Nicholas J Battersby; Roger H Brookes; Simon D Donkor; Abdulrahman Hammond; Hannah B Ibanga; David J Jeffries; Moses D Lugos; Martin O C Ota; Patrick K Owiafe; Robert Walton; Richard A Adegbola; Philip C Hill
Interferon-γ ELISPOT as a biomarker of treatment efficacy in latent tuberculosis infection: a clinical trial.
American journal of respiratory and critical care medicine 2013;187(4):439-45.
2010: K Touray; I M O Adetifa; Adama Jallow; J Rigby; David J Jeffries; Yin Bun Cheung; Simon A Donkor; Richard A Adegbola; Philip C Hill
Spatial analysis of tuberculosis in an urban west African setting: is there evidence of clustering?
Tropical medicine & international health : TM & IH 2010;15(6):664-72.
2010: Ifedayo M O Adetifa; Martin O C Ota; David J Jeffries; Abdulrahman Hammond; Moses D Lugos; Simon Donkor; Owiafe Patrick; Richard A Adegbola; Philip C Hill
Commercial interferon gamma release assays compared to the tuberculin skin test for diagnosis of latent Mycobacterium tuberculosis infection in childhood contacts in the Gambia.
The Pediatric infectious disease journal 2010;29(5):439-43.
2010: I M O Adetifa; Martin O C Ota; Brigitte Walther; Abdulrahman Hammond; Moses D Lugos; David J Jeffries; Simon A Donkor; Richard A Adegbola; Philip C Hill
Decay kinetics of an interferon gamma release assay with anti-tuberculosis therapy in newly diagnosed tuberculosis cases.
PloS one 2010;5(9):.
2010: Jayne S Sutherland; Bouke C de Jong; David J Jeffries; I M O Adetifa; Martin O C Ota
Production of TNF-alpha, IL-12(p40) and IL-17 can discriminate between active TB disease and latent infection in a West African cohort.
PloS one 2010;5(8):e12365.
2009: I M O Adetifa; Philip C Hill; David J Jeffries; Dolly Jackson-Sillah; H B Ibanga; G Bah; Simon A Donkor; Tumani Corrah; Richard A Adegbola
Haematological values from a Gambian cohort--possible reference range for a West African population.
International journal of laboratory hematology 2009;31(6):615-22.
2009: Jayne S Sutherland; David J Jeffries; Simon Donkor; Brigitte Walther; Philip C Hill; Ifedayo M O Adetifa; Richard A Adegbola; Martin O C Ota
High granulocyte/lymphocyte ratio and paucity of NKT cells defines TB disease in a TB-endemic setting.
Tuberculosis (Edinburgh, Scotland) 2009;89(6):398-404.
2009: David J Jeffries; Neil Abernethy; Bouke C de Jong
Supervised learning for the automated transcription of spacer classification from spoligotype films.
BMC bioinformatics 2009;10():248.
2008: Yin Bun Cheung; David J Jeffries; Andrew Thomson; Paul Milligan
A simple approach to test for interaction between intervention and an individual-level variable in community randomized trials.
Tropical medicine & international health : TM & IH 2008;13(2):247-55.
2008: Roger H Brookes; Philip C Hill; Patrick K Owiafe; Hannah B Ibanga; David J Jeffries; Simon A Donkor; Helen A Fletcher; Abdulrahman Hammond; Christian Lienhardt; Richard A Adegbola; Helen McShane; Adrian V S Hill
Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa.
PloS one 2008;3(8):e2921.
2008: David J C Miles; Marianne A B van der Sande; David J Jeffries; Steve Kaye; Olubukola Ojuola; Mariama Sanneh; Momodou Cox; Melba S Palmero; Ebrima S Touray; Pauline Waight; Sarah Rowland-Jones; Hilton Whittle; Arnaud Marchant
Maintenance of large subpopulations of differentiated CD8 T-cells two years after cytomegalovirus infection in Gambian infants.
PloS one 2008;3(8):e2905.
2008: Maimuna Mendy; Samuel J McConkey; Marianne A B Sande van der; Sarah Crozier; Steve Kaye; David J Jeffries; Andrew J Hall; Hilton C Whittle
Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia.
Virology journal 2008;5():49.
2007: Joann M McDermid; Assan Jaye; Maarten Schim van der Loeff; Jim Todd; Chris Bates; Steve Austin; David J Jeffries; Akum Aveika Awasana; Akum A Whittlex; Andrew M Prentice
Elevated iron status strongly predicts mortality in West African adults with HIV infection.
Journal of acquired immune deficiency syndromes (1999) 2007;46(4):498-507.
2007: S Burl; Philip C Hill; David J Jeffries; Martin Holland; Annette Fox; Moses D Lugos; Richard A Adegbola; Graham Rook; A Zumla; Keith P W J McAdam; Roger H Brookes
FOXP3 gene expression in a tuberculosis case contact study.
Clinical and experimental immunology 2007;149(1):117-22.
2007: Annette Fox; David J Jeffries; Philip C Hill; Abdulrahman Hammond; Moses D Lugos; Dolly Jackson-Sillah; Simon A Donkor; Patrick K Owiafe; Keith P W J McAdam; Roger H Brookes
ESAT-6 and CFP-10 can be combined to reduce the cost of testing for Mycobacterium tuberculosis infection, but CFP-10 responses associate with active disease.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2007;101(7):691-8.
2007: Philip C Hill; Roger H Brookes; Annette Fox; Dolly Jackson-Sillah; David J Jeffries; Moses D Lugos; Simon A Donkor; I M O Adetifa; Bouke C de Jong; Alexander Aiken; Richard A Adegbola; Keith P W J McAdam
Longitudinal assessment of an ELISPOT test for Mycobacterium tuberculosis infection.
PLoS medicine 2007;4(6):e192.
2007: David J C Miles; Marianne A B van der Sande; David J Jeffries; Steve Kaye; Jamila Ismaili; Olubukola Ojuola; Mariama Sanneh; Ebrima S Touray; Pauline Waight; Sarah Rowland-Jones; Hilton Whittle; Arnaud Marchant
Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation.
Journal of virology 2007;81(11):5766-76.
2007: Bouke C de Jong; Philip C Hill; Alexander Aiken; David J Jeffries; Anthony Onipede; Peter M Small; Richard A Adegbola; Tumani Corrah
Clinical presentation and outcome of tuberculosis patients infected by M. africanum versus M. tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2007;11(4):450-6.
2007: James Cavenaugh; Paul Snell; David J Jeffries; Pauline Waight; Samuel J McConkey
A relational database for management of flow cytometry and ELISpot clinical trial data.
Cytometry. Part B, Clinical cytometry 2007;72(1):49-62.
2007: I M O Adetifa; Moses D Lugos; Abdulrahman Hammond; David J Jeffries; Simon A Donkor; Richard A Adegbola; Philip C Hill
Comparison of two interferon gamma release assays in the diagnosis of Mycobacterium tuberculosis infection and disease in The Gambia.
BMC infectious diseases 2007;7():122.
2007: Marianne A B van der Sande; Pauline Waight; Maimuna Mendy; Syed Zaman; Steve Kaye; Omar Sam; Abi Kahn; David J Jeffries; Aveika A Akum; Andrew J Hall; Ebrima Bah; Samuel J McConkey; Pierre Hainaut; Hilton C Whittle
Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence.
PloS one 2007;2(8):e753.
2007: Marianne A B van der Sande; Steve Kaye; David J C Miles; Pauline Waight; David J Jeffries; Olubukola O Ojuola; Melba Palmero; Margaret Pinder; Jamila Ismaili; Katie L Flanagan; Akum A Aveika; Akram Zaman; Sarah Rowland-Jones; Samuel J McConkey; Hilton C Whittle; Arnaud Marchant
Risk factors for and clinical outcome of congenital cytomegalovirus infection in a peri-urban West-African birth cohort.
PloS one 2007;2(6):e492.
2007: Philip C Hill; David J Jeffries; Roger H Brookes; Annette Fox; Dolly Jackson-Sillah; Moses D Lugos; Simon A Donkor; Bouke C de Jong; Tumani Corrah; Richard A Adegbola; Keith P W J McAdam
Using ELISPOT to expose false positive skin test conversion in tuberculosis contacts.
PloS one 2007;2(1):e183.
2006: Nkoyo Faal; Robin L Bailey; David J Jeffries; Hassan Joof; Isatou Sarr; Mass Laye; David C W Mabey; Martin Holland
Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection?
PLoS medicine 2006;3(8):e266.
2006: Melody G Duvall; Assan Jaye; Tao Dong; Jason M Brenchley; Abraham Alabi; David J Jeffries; Marianne A B van der Sande; Toyin O Togun; Samuel J McConkey; Daniel C Douek; Andrew J McMichael; Hilton C Whittle; Richard A Koup; Sarah L Rowland-Jones
Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6973-81.
2006: Marianne A B van der Sande; Pauline Waight; Maimuna Mendy; Pura Rayco-Solon; P Hutt; T Fulford; C Doherty; Samuel J McConkey; David J Jeffries; Andrew J Hall; Hilton C Whittle
Long-term protection against carriage of hepatitis B virus after infant vaccination.
The Journal of infectious diseases 2006;193(11):1528-35.
2006: Philip C Hill; Roger H Brookes; I M O Adetifa; Annette Fox; Dolly Jackson-Sillah; Moses D Lugos; Simon A Donkor; Roger J Marshall; Stephen R C Howie; Tumani Corrah; David J Jeffries; Richard A Adegbola; Keith P W J McAdam
Comparison of enzyme-linked immunospot assay and tuberculin skin test in healthy children exposed to Mycobacterium tuberculosis.
Pediatrics 2006;117(5):1542-8.
2006: Bouke C de Jong; Philip C Hill; Roger H Brookes; Sebastien Gagneux; David J Jeffries; Jacob K Otu; Simon A Donkor; Annette Fox; Keith P W J McAdam; Peter M Small; Richard A Adegbola
Mycobacterium africanum elicits an attenuated T cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and their household contacts.
The Journal of infectious diseases 2006;193(9):1279-86.
2006: Matthew J Burton; Martin Holland; David J Jeffries; David C W Mabey; Robin L Bailey
Conjunctival chlamydial 16S ribosomal RNA expression in trachoma: is chlamydial metabolic activity required for disease to develop?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(4):463-70.
2006: David J Jeffries; Philip C Hill; Annette Fox; Moses D Lugos; Dolly Jackson-Sillah; Richard A Adegbola; Roger H Brookes
Identifying ELISPOT and skin test cut-offs for diagnosis of Mycobacterium tuberculosis infection in The Gambia.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2006;10(2):192-8.
2006: Philip C Hill; Roger H Brookes; Annette Fox; Dolly Jackson-Sillah; Moses D Lugos; David J Jeffries; Simon A Donkor; Richard A Adegbola; Keith P W J McAdam
Surprisingly high specificity of the PPD skin test for M. tuberculosis infection from recent exposure in The Gambia.
PloS one 2006;1():e68.
2005: Philip C Hill; Dolly Jackson-Sillah; Annette Fox; Kees L M C Franken; Moses D Lugos; David J Jeffries; Simon A Donkor; Abdulrahman Hammond; Richard A Adegbola; Tom H M Ottenhoff; Michel Klein; Roger H Brookes
ESAT-6/CFP-10 fusion protein and peptides for optimal diagnosis of mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in the Gambia.
Journal of clinical microbiology 2005;43(5):2070-4.
2005: Philip C Hill; Annette Fox; David J Jeffries; Dolly Jackson-Sillah; Moses D Lugos; Patrick K Owiafe; Simon A Donkor; Abdulrahman Hammond; Tumani Corrah; Richard A Adegbola; Keith P W J McAdam; Roger H Brookes
Quantitative T cell assay reflects infectious load of Mycobacterium tuberculosis in an endemic case contact model.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40(2):273-8.
2004: Matthew J Burton; Robin L Bailey; David J Jeffries; David C W Mabey; Martin Holland
Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic.
Infection and immunity 2004;72(12):7352-6.
2004: Marianne A B van der Sande; Maarten Schim van der Loeff; Rachel C Bennett; Mary Dowling; Akum A Aveika; Toyin O Togun; Saihou Sabally; David J Jeffries; Richard A Adegbola; Ramu Sarge-Njie; Assan Jaye; Tumani Corrah; Samuel J McConkey; Hilton C Whittle
Incidence of tuberculosis and survival after its diagnosis in patients infected with HIV-1 and HIV-2.
AIDS (London, England) 2004;18(14):1933-41.
2004: David J Jeffries; Simon A Donkor; Roger H Brookes; Annette Fox; Philip C Hill
Design and implementation of relational databases relevant to the diverse needs of a tuberculosis case contact study in the Gambia.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2004;8(9):1095-9.
2004: Helen A Fletcher; Patrick K Owiafe; David J Jeffries; Philip Hill; Graham Rook; Alimuddin Zumla; T Mark Doherty; Roger H Brookes
Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.
Immunology 2004;112(4):669-73.
2004: Philip C Hill; Roger H Brookes; Annette Fox; Katherine Fielding; David J Jeffries; Dolly Jackson-Sillah; Moses D Lugos; Patrick K Owiafe; Simon A Donkor; Abdulrahman Hammond; Jacob K Otu; Tumani Corrah; Richard A Adegbola; Keith P W J McAdam
Large-scale evaluation of enzyme-linked immunospot assay and skin test for diagnosis of Mycobacterium tuberculosis infection against a gradient of exposure in The Gambia.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;38(7):966-73.
2003: M O C Ota; Marianne A B van der Sande; Gijs Walraven; David J Jeffries; Ousman A Nyan; Arnaud Marchant; Keith P W J McAdam
Absence of association between delayed type hypersensitivity to tuberculin and atopy in children in The Gambia.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(6):731-6.