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Karthik Jeganathan

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Darren J Baker; Atta Behfar; Ruben Crespo-Diaz; Meelad M Dawlaty; Karthik B Jeganathan; Liviu Malureanu; Santiago Reyes; Lauren Seaburg; Virginia Shapiro; Andre Terzic; Bart van De Sluis; Janine H van Ree; Tobias Wijshake; Jan M A van Deursen
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
Robin M Ricke; Andrew M Harrison; Karthik B Jeganathan; Liviu Malureanu; Jan M A van Deursen
Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.
Tobias Wijshake; Darren J Baker; Karthik B Jeganathan; Liviu A Malureanu; Bart van De Sluis; Jan M A van Deursen
Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.

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All Publications

2013: Darren J Baker; Atta Behfar; Ruben Crespo-Diaz; Meelad M Dawlaty; Karthik B Jeganathan; Liviu Malureanu; Santiago Reyes; Lauren Seaburg; Virginia Shapiro; Andre Terzic; Bart van De Sluis; Janine H van Ree; Tobias Wijshake; Jan M A van Deursen
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
Nature cell biology 2013;15(1):96-102.
2012: Robin M Ricke; Andrew M Harrison; Karthik B Jeganathan; Liviu Malureanu; Jan M A van Deursen
Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.
The Journal of cell biology 2012;199(6):931-49.
2012: Tobias Wijshake; Darren J Baker; Karthik B Jeganathan; Liviu A Malureanu; Bart van De Sluis; Jan M A van Deursen
Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.
PLoS genetics 2012;8(12):e1003138.
2011: Masakazu Hamada; Karthik B Jeganathan; Jomon Joseph; Ralph H Kehlenbach; Liviu Malureanu; Janine H van Ree; Sarah Wälde; Anna Haeger; Jan M A van Deursen
Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.
The Journal of cell biology 2011;194(4):597-612.
2011: Robin M Ricke; Karthik B Jeganathan; Jan M A van Deursen
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation.
The Journal of cell biology 2011;193(6):1049-64.
2010: Liviu Malureanu; Karthik B Jeganathan; Fang Jin; Darren J Baker; Janine H van Ree; Oliver Gullon; Zheyan Chen; John R Henley; Jan M A van Deursen
Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.
The Journal of cell biology 2010;191(2):313-29.
2010: Fang Jin; Masakazu Hamada; Liviu Malureanu; Karthik B Jeganathan; Wei Zhou; Dean E Morbeck; Jan M A van Deursen
Cdc20 is critical for meiosis I and fertility of female mice.
PLoS genetics 2010;6(9):.
2010: Janine H van Ree; Karthik B Jeganathan; Liviu Malureanu; Jan M A van Deursen
Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.
The Journal of cell biology 2010;188(1):83-100.
2009: Darren J Baker; Fang Jin; Karthik B Jeganathan; Jan M A van Deursen
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.
Cancer cell 2009;16(6):475-86.
2009: Yu Liu; Liviu Malureanu; Karthik B Jeganathan; David Dinh Tran; Lonn D Lindquist; Jan M A van Deursen; Richard J Bram
CAML loss causes anaphase failure and chromosome missegregation.
Cell cycle (Georgetown, Tex.) 2009;8(6):940-9.
2009: Liviu A Malureanu; Karthik B Jeganathan; Masakazu Hamada; Lisa Wasilewski; James Davenport; Jan M A van Deursen
BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase.
Developmental cell 2009;16(1):118-31.
2008: Darren J Baker; Carmen Perez-Terzic; Fang Jin; Kevin Pitel; Nicolas J Niederländer; Karthik B Jeganathan; Satsuki Yamada; Santiago Reyes; Lois Rowe; H Jay Hiddinga; Norman L Eberhardt; Andre Terzic; Kevin S Pitel; Jan M A van Deursen
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency.
Nature cell biology 2008;10(7):825-36.
2008: Meelad M Dawlaty; Liviu Malureanu; Karthik B Jeganathan; Esther Kao; Claudio Sustmann; Samuel Tahk; Ke Shuai; Rudolf Grosschedl; Jan M A van Deursen
Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.
Cell 2008;133(1):103-15.
2007: Karthik B Jeganathan; Liviu Malureanu; Darren J Baker; Susan C Abraham; Jan M A van Deursen
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
The Journal of cell biology 2007;179(2):255-67.
2006: Karthik B Jeganathan; Jan M A van Deursen
Differential mitotic checkpoint protein requirements in somatic and germ cells.
Biochemical Society transactions 2006;34(Pt 4):583-6.
2006: Darren J Baker; Karthik B Jeganathan; Liviu Malureanu; Carmen Perez-Terzic; Andre Terzic; Jan M A van Deursen
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.
The Journal of cell biology 2006;172(4):529-40.
2006: Karthik B Jeganathan; Darren J Baker; Jan M A van Deursen
Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition.
Cell cycle (Georgetown, Tex.) 2006;5(4):366-70.
2005: Karthik B Jeganathan; Liviu Malureanu; Jan M A van Deursen
The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.
Nature 2005;438(7070):1036-9.
2004: Darren J Baker; Karthik B Jeganathan; J Douglas Cameron; Michael Thompson; Subhash Juneja; Alena Kopecka; Rajiv Kumar; Robert B Jenkins; Piet C de Groen; Patrick Roche; Jan M A van Deursen
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.
Nature genetics 2004;36(7):744-9.
2003: J Ramesh Babu; Karthik B Jeganathan; Darren J Baker; Xiaosheng Wu; Ningling Kang-Decker; Jan M A van Deursen
Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation.
The Journal of cell biology 2003;160(3):341-53.