Arco Jeng

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LaSala Daniel; Shibanaka Yasuhiko; Jeng Arco Y
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Huang Bing S; White Roselyn A; Jeng Arco Y; Leenen Frans H H
Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats.
Huang Bing S; White Roselyn A; Ahmad Monir; Tan Junhui; Jeng Arco Y; Leenen Frans H H
Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.

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All Publications

2009: LaSala Daniel; Shibanaka Yasuhiko; Jeng Arco Y
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Analytical biochemistry 2009;394(1):56-61.
2009: Huang Bing S; White Roselyn A; Jeng Arco Y; Leenen Frans H H
Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;296(4):R994-R1000.
2009: Huang Bing S; White Roselyn A; Ahmad Monir; Tan Junhui; Jeng Arco Y; Leenen Frans H H
Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.
Cardiovascular research 2009;81(3):574-81.
2008: Huang Bing S; White Roselyn A; Ahmad Monir; Jeng Arco Y; Leenen Frans H H
Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(1):R166-72.
2007: Daull Philippe; Jeng Arco Y; Battistini Bruno
Towards triple vasopeptidase inhibitors for the treatment of cardiovascular diseases.
Journal of cardiovascular pharmacology 2007;50(3):247-56.
2007: Lin Chih-Lung; Kwan Aij-Lie; Dumont Aaron S; Su Yu-Feng; Kassell Neal F; Wang Chih-Jen; Wu Shu-Chuan; Kuo Ching-Ling; Huang Ching-Shan; Jeng Arco Y; Liu Chin-San
Attenuation of experimental subarachnoid hemorrhage-induced increases in circulating intercellular adhesion molecule-1 and cerebral vasospasm by the endothelin-converting enzyme inhibitor CGS 26303.
Journal of neurosurgery 2007;106(3):442-8.
2007: Chou An-Kuo; Chen Tai-I; Winardi William; Dai Ming-Hong; Chen Shih-Chieh; Howng Shen-Long; Yen Chun-Po; Lin Tzu-Kan; Jeng Arco Y; Kwan Aij-Lie
Functional neuroprotective effect of CGS 26303, a dual ECE inhibitor, on ischemic-reperfusion spinal cord injury in rats.
Experimental biology and medicine (Maywood, N.J.) 2007;232(2):214-8.
2006: Lin Chih-Lung; Winardi William; Jeng Arco Y; Kwan Aij-Lie
Endothelin-converting enzyme inhibitors for the treatment of subarachnoid hemorrhage-induced vasospasm.
Neurological research 2006;28(7):721-9.
2006: Kwan Aij-Lie; Lin Chih-Lung; Yen Chun-Po; Winardi William; Su Yu-Feng; Winardi Daniel; Dai Zen-Kong; Jeng Arco Y; Kassell Neal F; Howng Sheng-Long; Wang Chih-Jen
Prevention and reversal of vasospasm and ultrastructural changes in basilar artery by continuous infusion of CGS 35066 following subarachnoid hemorrhage.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):1069-74.
2006: Lin Chih-Lung; Dumont Aaron S; Wu Shu-Chuan; Wang Chih-Jen; Howng Sheng-Long; Huang Yan-Fen; Wong Wee-Yen; Kassell Neal F; Jeng Arco Y; Kwan Aij-Lie
17beta-estradiol inhibits endothelin-1 production and attenuates cerebral vasospasm after experimental subarachnoid hemorrhage.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):1054-7.
2006: Chou Shah-Hwa; Chai Chee-Yin; Wu Jiunn-Ren; Tan Mian-Shin; Chiu Chaw-Chi; Chen Ing-Jun; Jeng Acro Y; Chang Chung-I; Kwan Aij-Lie; Dai Zen-Kong
The effects of debanding on the lung expression of ET-1, eNOS, and cGMP in rats with left ventricular pressure overload.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):954-9.
2006: Tan Mian-Shin; Chai Chee-Yin; Wu Jiunn-Ren; Yeh Jwu-Lai; Chen Ing-Jun; Kwan Aij-Lie; Jeng Arco Y; Yang Huey-Yu; Lee Meng-Hsun; Dai Zen-Kong
Differential change in expression of pulmonary ET-1 and eNOS in rats after chronic left ventricular pressure overload.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):948-53.
2006: Dai Zen-Kong; Tan Mian-Shin; Chai Chee-Yin; Chou Shah-Hwa; Lin Pei-Chin; Yeh Jwu-Lai; Jeng Arco Y; Chang Chung-I; Chen Ing-Jun; Wu Jiunn-Ren
Effects of sildenafil on pulmonary hypertension and levels of ET-1, eNOS, and cGMP in aorta-banded rats.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):942-7.
2006: Daull P; Blouin A; Belleville K; Beaudoin M; Arsenault D; Leonard H; Sirois P; Nantel F; Jeng A Y; Battistini B
Triple VPI CGS 35601 reduces high blood pressure in low-renin, high-salt Dahl salt-sensitive rats.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):830-3.
2006: Daull P; Blouin A; Beaudoin M; Gadbois S; Belleville K; Cayer J; Berthiaume N; Sirois P; Nantel F; Jeng A Y; Battistini B
The hemodynamic and metabolic profiles of Zucker diabetic fatty rats treated with a single molecule triple vasopeptidase inhibitor, CGS 35601.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):824-9.
2006: Daull P; Lepage R; Benrezzak O; Cayer J; Beaudoin M; Belleville K; Blouin A; Sirois P; Nantel F; Jeng A Y; Battistini B
The first preclinical pharmacotoxicological safety assessment of CGS 35601, a triple vasopeptidase inhibitor, in chronically instrumented, conscious, and unrestrained spontaneously hypertensive rats.
Drug and chemical toxicology 2006;29(2):183-202.
2005: Daull Philippe; Benrezzak Ouhida; Arsenault Dominique; Pheng Leng Hong; Blouin André; Cayer Julie; Beaudoin Myriam; Belleville Karine; Sirois Pierre; Nantel François; Jeng Arco Y; Battistini Bruno
Triple vasopeptidase inhibition normalizes blood pressure in conscious, unrestrained, and spontaneously hypertensive rats.
American journal of hypertension 2005;18(12 Pt 1):1606-13.
2005: Coppola Gary M; Kukkola Paivi J; Stanton James L; Neubert Alan D; Marcopulos Nicholas; Bilci Natalie A; Wang Hua; Tomaselli Hollis C; Tan Jenny; Aicher Thomas D; Knorr Douglas C; Jeng Arco Y; Dardik Beatriz; Chatelain Ricardo E
Perhydroquinolylbenzamides as novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Journal of medicinal chemistry 2005;48(21):6696-712.
2005: Mellin Virginie; Jeng Arco Y; Monteil Christelle; Renet Sylvanie; Henry Jean Paul; Thuillez Christian; Mulder Paul
Triple ACE-ECE-NEP inhibition in heart failure: a comparison with ACE and dual ECE-NEP inhibition.
Journal of cardiovascular pharmacology 2005;46(3):390-7.
2005: Fiebeler Anette; Nussberger Jürg; Shagdarsuren Erdenechimeg; Rong Song; Hilfenhaus Georg; Al-Saadi Nidal; Dechend Ralf; Wellner Maren; Meiners Silke; Maser-Gluth Christiane; Jeng Arco Y; Webb Randy L; Luft Friedrich C; Muller Dominik N
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Circulation 2005;111(23):3087-94.
2005: Emoto Noriaki; Raharjo Sunu Budhi; Isaka Daiji; Masuda Shigeru; Adiarto Suko; Jeng Arco Y; Yokoyama Mitsuhiro
Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats.
Hypertension 2005;45(6):1145-52.
2005: Battistini Bruno; Daull Philippe; Jeng Arco Y
CGS 35601, a triple inhibitor of angiotensin converting enzyme, neutral endopeptidase and endothelin converting enzyme.
Cardiovascular drug reviews 2005;23(4):317-30.
2004: Chang Chih-Zen; Yen Chin-Po; Winadi Daniel; Wu Shu-Chuan; Howng Sheng-Long; Lin Tze-Kan; Jeng Arco Y; Kassell Neal F; Kwan Aij-Lie
Neuroprotective effect of CGS 26303, an endothelin-converting enzyme inhibitor, on transient middle cerebral artery occlusion in rats.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S487-9.
2004: Yen Chun-Po; Chen Shih-Chieh; Lin Tze-Kan; Wu Shu-Chuan; Chang Chao-Yuah; Lue Sheng-I; Jeng Arco Y; Kassell Neal F; Kwan Aij-Lie
CGS 26303 upregulates mRNA expression of heme oxygenase-1 in brain tissue of rats subjected to experimental subarachnoid hemorrhage.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S474-8.
2004: Daull Philippe; Blouin André; Sirois Pierre; Nantel François; Jeng Arco Y; Battistini Bruno
Triple vasopeptidase inhibition of angiotensin-converting enzyme/neutral endopeptidase/endothelin-converting enzyme activities on the hemodynamic profile of chronically instrumented unrestrained conscious spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S398-401.
2004: Battistini B; Verreault M; Ayach B; Blouin A; Cernacek P; Jeng A Y; Wessale J; Opgenorth T; Tsang J
Role of the endothelin system in secondary pulmonary hypertension related to air embolism: lessons learned from testing four classes of endothelin blockers in a rat model.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S386-9.
2004: Dai Zen-Kong; Tan Mian-Shin; Chai Chee-Yin; Chen Ing-Jun; Jeng Arco Y; Kwan Aij-Lie; Howng Sheng-Long; Lu Chu-Chong; Wu Jiunn-Ren
Differential changes in endothelin-1 and endothelial nitric oxide synthase gene expression in rats with a chronic high pulmonary flow.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S341-5.
2004: Hu Chii-Whei; Webb Randy L; Jeng Arco Y
Synergistic stimulation of aldosterone production in human adrenocortical carcinoma NCI-H295R cells by endothelin-1 and angiotensin II.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S289-92.
2004: Trapani Angelo J; Beil Michael E; Bruseo Charles W; Savage Paula; Firooznia Fariborz; Jeng Arco Y
CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S211-5.
2004: Skiles Jerry W; Gonnella Nina C; Jeng Arco Y
The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors.
Current medicinal chemistry 2004;11(22):2911-77.
2004: Lin Chih-Lung; Jeng Arco Y; Howng Shen-Long; Kwan Aij-Lie
Endothelin and subarachnoid hemorrhage-induced cerebral vasospasm: pathogenesis and treatment.
Current medicinal chemistry 2004;11(13):1779-91.
2004: Mulder Paul; Barbier Stephane; Monteil Christelle; Jeng Arco Y; Henry Jean Paul; Renet Sylvanie; Thuillez Christian
Sustained improvement of cardiac function and prevention of cardiac remodeling after long-term dual ECE-NEP inhibition in rats with congestive heart failure.
Journal of cardiovascular pharmacology 2004;43(4):489-94.
2004: Dai Zen-Kong; Tan Mian-Shin; Chai Chee-Yin; Yeh Jwu-Lai; Chou Shah-Hwa; Chiu Chaw-Chi; Jeng Arco Y; Chen Ing-Jun; Wu Jiunn-Ren
Upregulation of endothelial nitric oxide synthase and endothelin-1 in pulmonary hypertension secondary to heart failure in aorta-banded rats.
Pediatric pulmonology 2004;37(3):249-56.
2003: Jeng Arco Y
Utility of endothelin-converting enzyme inhibitors for the treatment of cardiovascular diseases.
Current opinion in investigational drugs (London, England : 2000) 2003;4(9):1076-81.
2003: Raychaudhuri Anil; Chou Mary; Weetall Marla; Jeng Arco Y
Blockade of integrin VLA-4 prevents inflammation and matrix metalloproteinase expression in a murine model of accelerated collagen-induced arthritis.
Inflammation 2003;27(2):107-13.
2002: Firooznia Fariborz; Gude Candido; Chan Kenneth; Tan Jenny; Fink Cynthia A; Savage Paula; Beil Michael E; Bruseo Charles W; Trapani Angelo J; Jeng Arco Y
Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1.
Bioorganic & medicinal chemistry letters 2002;12(21):3059-62.
2002: Chang Chih-Zen; Winardi Daniel; Lin Chih-Lung; Kwan Aij-Lie; Jeng Arco Y; Kassell Neal F; Howng Shen-Long; Lee Kevin S
Attenuation of hemolysate-induced cerebrovascular endothelial cell injury and of production of endothelin-1 and big endothelin-1 by an endothelin-converting enzyme inhibitor.
Surgical neurology 2002;58(3-4):181-7; discussion 187-8.
2002: Kwan Aij-Lie; Lin Chih-Lung; Chang Chih-Zen; Winardi Daniel; Yen Chun-Po; Wu Shu-Chuan; Lee Kevin S; Kassell Neal F; Howng Shen-Long; Savage Paula; Jeng Arco Y
Oral administration of an inhibitor of endothelin-converting enzyme attenuates cerebral vasospasm following experimental subarachnoid haemorrhage in rabbits.
Clinical science (London, England : 1979) 2002;103 Suppl 48():414S-417S.
2002: Ayach Bilal; Tsang John; Jeng Arco Y; Blouin André; Gosselin Mélanie; Wang Fu-Hou; Wu-Wong Jinshyun R; Wessale Jerry; Opgenorth Terry J; Battistini Bruno
Effects of a selective endothelin A receptor antagonist, ABT-627, in healthy normotensive anaesthetized rats developing acute pulmonary air embolism.
Clinical science (London, England : 1979) 2002;103 Suppl 48():371S-375S.
2002: Battistini Bruno; Ayach Bilal; Molez Stéphanie; Blouin Andre; Jeng Arco Y
Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats.
Clinical science (London, England : 1979) 2002;103 Suppl 48():363S-366S.
2002: De Campo Benjamin A; Goldie Roy G; Jeng Arco Y; Henry Peter J
Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice.
Clinical science (London, England : 1979) 2002;103 Suppl 48():353S-356S.
2002: Dai Zen-Kong; Tan Mian-Shin; Chai Chee-Yin; Chen Ing-Jun; Jeng Arco Y; Wu Jiunn-Ren
Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat.
Clinical science (London, England : 1979) 2002;103 Suppl 48():289S-293S.
2002: Trapani Angelo J; Beil Michael E; Bruseo Charles W; Fink Cynthia A; Hoyer Denton; Savage Paula; Jeng Arco Y
Effects of the ECE/NEP inhibitor CGS 34225 on the big ET-1-induced pressor response and plasma atrial natriuretic peptide concentration in conscious rats.
Clinical science (London, England : 1979) 2002;103 Suppl 48():102S-106S.
2002: Jeng Arco Y; Savage Paula; Beil Michael E; Bruseo Charles W; Hoyer Denton; Fink Cynthia A; Trapani Angelo J
CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11.
Clinical science (London, England : 1979) 2002;103 Suppl 48():98S-101S.
2002: Kulathila Raviraj; Clark Kirk; Savage Paula; Bowen Benjamin R; Emoto Noriaki; Yanagisawa Masashi; Jeng Arco Y
Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a.
Clinical science (London, England : 1979) 2002;103 Suppl 48():94S-97S.
2002: Savage Paula; Jeng Arco Y
Upregulation of endothelin-1 binding in tissues of salt-loaded stroke-prone spontaneously hypertensive rats.
Canadian journal of physiology and pharmacology 2002;80(5):470-4.
2002: Ksander Gary M; Shetty Suraj S; DelGrande Dominick; Balwierczak Joseph L; Bruseo Charles W; Savage Paula; deJesus Reynalda; Yuan Andrew; Webb Randy L; Jeng Arco Y
Dipeptide sulfonamides as endothelin ETA/ETB receptor antagonists.
Canadian journal of physiology and pharmacology 2002;80(5):464-9.
2002: Pham Dung; Jeng Arco Y; Plante Sylvain; Escher Emanuel; Battistini Bruno
Inhibition of endothelin-converting enzyme for protection against neointimal proliferation following balloon angioplasty of the rat carotid artery.
Canadian journal of physiology and pharmacology 2002;80(5):450-7.
2002: Jeng Arco Y; Mulder Paul; Kwan Aij-Lie; Battistini Bruno
Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications.
Canadian journal of physiology and pharmacology 2002;80(5):440-9.
2002: Kwan Aij-Lie; Lin Chih-Lung; Chang Chih-Zen; Wu Shu-Chuan; Howng Shen-Long; Jeng Arco Y
Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor.
Neuroreport 2002;13(2):197-9.
2002: Chang C-Z; Winardi D; Loh J-K; Kung S-S; Howng S-L; Jeng A Y; Kwan A-L
Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine.
Acta neurochirurgica 2002;144(2):189-93; discussion 193.
2001: Kwan A L; Lin C L; Chang C Z; Wu H J; Hwong S L; Jeng A Y; Lee K S
Continuous intravenous infusion of CGS 26303, an endothelin-converting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage.
Neurosurgery 2001;49(2):422-7; discussion 427-9.
2001: Kukkola P J; Bilci N A; Ikler T; Savage P; Shetty S S; DelGrande D; Jeng A Y
Isoindolines: a new series of potent and selective endothelin-A receptor antagonists.
Bioorganic & medicinal chemistry letters 2001;11(13):1737-40.
2001: Skiles J W; Gonnella N C; Jeng A Y
The design, structure, and therapeutic application of matrix metalloproteinase inhibitors.
Current medicinal chemistry 2001;8(4):425-74.
2001: Firooznia F; Gude C; Chan K; Fink C A; Qiao Y; Satoh Y; Marcopoulos N; Savage P; Beil M E; Bruseo C W; Trapani A J; Jeng A Y
Synthesis and biological activity of novel potent endothelin-converting enzyme-1 inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(3):375-8.
2000: Feldman D L; Mogelesky T C; Chou M; Jeng A Y
Attenuation of puromycin aminonucleoside-induced glomerular lesions in rats by CGS 26303, a dual neutral endopeptidase/endothelin-converting enzyme inhibitor.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S342-5.
2000: Feldman D L; Mogelesky T C; Chou M; Jeng A Y
Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S255-9.
2000: Kwan A L; Lin C L; Chang C Z; Winardi D; Yen C P; Howng S L; Jeng A Y
Effects of endothelin-converting enzyme inhibitors on hemolysate-induced morphological changes and production of endothelin-1 in bovine cerebrovascular endothelial cells.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S160-2.
2000: Trapani A J; Beil M E; Bruseo C W; De Lombaert S; Jeng A Y
Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S40-3.
2000: Jeng A Y; De Lombaert S; Beil M E; Bruseo C W; Savage P; Chou M; Trapani A J
Design and synthesis of a potent and selective endothelin-converting enzyme inhibitor, CGS 35066.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S36-9.
2000: Fink C A; Moskal M; Firooznia F; Hoyer D; Symonsbergen D; Wei D; Qiao Y; Savage P; Beil M E; Trapani A J; Jeng A Y
Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1.
Bioorganic & medicinal chemistry letters 2000;10(17):2037-9.
2000: De Lombaert S; Blanchard L; Stamford L B; Tan J; Wallace E M; Satoh Y; Fitt J; Hoyer D; Simonsbergen D; Moliterni J; Marcopoulos N; Savage P; Chou M; Trapani A J; Jeng A Y
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
Journal of medicinal chemistry 2000;43(3):488-504.
2000: Trapani A J; De Lombaert S; Beil M E; Bruseo C W; Savage P; Chou M; Jeng A Y
CGS 34043: a non-peptidic, potent and long-acting dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11.
Life sciences 2000;67(9):1025-33.
1999: Henry P J; Carr M J; Goldie R G; Jeng A Y
The role of endothelin in mediating virus-induced changes in endothelinB receptor density in mouse airways.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(1):92-7.
1999: Jeng A Y; Chou M; Sawyer W K; Caplan S L; Von Linden-Reed J; Jeune M; Prescott M F
Enhanced expression of matrix metalloproteinase-3, -12, and -13 mRNAs in the aortas of apolipoprotein E-deficient mice with advanced atherosclerosis.
Annals of the New York Academy of Sciences 1999;878():555-8.
1999: Prescott M F; Sawyer W K; Von Linden-Reed J; Jeune M; Chou M; Caplan S L; Jeng A Y
Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury.
Annals of the New York Academy of Sciences 1999;878():179-90.
1998: Jeng A Y; Chou M; Parker D T
Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase.
Bioorganic & medicinal chemistry letters 1998;8(8):897-902.
1998: Wallace E M; Moliterni J A; Moskal M A; Neubert A D; Marcopulos N; Stamford L B; Trapani A J; Savage P; Chou M; Jeng A Y
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.
Journal of medicinal chemistry 1998;41(9):1513-23.
1998: Ksander G M; Savage P; Trapani A J; Balwierczak J L; Jeng A Y
Benzofused macrocyclic lactams as triple inhibitors of endothelin-converting enzyme, neutral endopeptidase 24.11, and angiotensin-converting enzyme.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S71-3.
1998: Shetty S S; Savage P; DelGrande D; De Lombaert S; Jeng A Y
Characterization of CGS 31447, a potent and nonpeptidic endothelin-converting enzyme inhibitor.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S68-70.
1998: Savage P; De Lombaert S; Shimada K; Tanzawa K; Jeng A Y
Differential inhibition of wild-type endothelin-converting enzyme-1 and its mutants.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S16-8.
1997: Jeng A Y; Fujimoto R A; Chou M; Tan J; Erion M D
Suppression of substance P biosynthesis in sensory neurons of dorsal root ganglion by prodrug esters of potent peptidylglycine alpha-amidating monooxygenase inhibitors.
The Journal of biological chemistry 1997;272(23):14666-71.
1997: Hu S; Kim H S; Savage P; Jeng A Y
Activation of BK(Ca) channel via endothelin ET(A) receptors in porcine coronary artery smooth muscle cells.
European journal of pharmacology 1997;324(2-3):277-82.
1996: Fink C A; Carlson J E; McTaggart P A; Qiao Y; Webb R; Chatelain R; Jeng A Y; Trapani A J
Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
Journal of medicinal chemistry 1996;39(16):3158-68.
1995: Balwierczak J L; Kukkola P J; Savage P; Jeng A Y
Effects of metalloprotease inhibitors on smooth muscle endothelin-converting enzyme activity.
Biochemical pharmacology 1995;49(3):291-6.
1995: Jeng A Y; Wong M; Duelfer T; Shapiro S D; Kramer R A; Hu S
Mouse macrophage metalloelastase expressed in bacteria absolutely requires zinc for activity.
Journal of biochemistry 1995;117(1):216-21.
1995: Trapani A J; De Lombaert S; Kuzmich S; Jeng A Y
Inhibition of big ET-1-induced pressor response by an orally active dual inhibitor of endothelin-converting enzyme and neutral endopeptidase 24.11.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S69-71.
1995: Kukkola P J; Savage P; Sakane Y; Berry J C; Bilci N A; Ghai R D; Jeng A Y
Differential structure-activity relationships of phosphoramidon analogues for inhibition of three metalloproteases: endothelin-converting enzyme, neutral endopeptidase, and angiotensin-converting enzyme.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S65-8.
1995: Balwierczak J L; Bruseo C W; DelGrande D; Jeng A Y; Savage P; Shetty S S
Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S393-6.
1995: Shetty S S; DelGrande D; Savage P; Ksander G M; Jeng A Y
Delineation of endothelin receptor subtypes in rat and rabbit aortas.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S310-3.
1994: Erion M D; Tan J; Wong M; Jeng A Y
Inhibition of peptidylglycine alpha-amidating monooxygenase by N-substituted homocysteine analogs.
Journal of medicinal chemistry 1994;37(26):4430-7.
1994: De Lombaert S; Ghai R D; Jeng A Y; Trapani A J; Webb R L
Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme.
Biochemical and biophysical research communications 1994;204(1):407-12.
1994: Gilligan J P; Lovato S J; Erion M D; Jeng A Y
Modulation of carrageenan-induced hind paw edema by substance P.
Inflammation 1994;18(3):285-92.
1994: Deng A Y; Martin L L; Balwierczak J L; Jeng A Y
Purification and characterization of an endothelin degradation enzyme from rat kidney.
Journal of biochemistry 1994;115(1):120-5.
1993: Trapani A J; Balwierczak J L; Lappe R W; Stanton J L; Graybill S C; Hopkins M F; Savage P; Sperbeck D M; Jeng A Y
Effects of metalloprotease inhibitors on the conversion of proendothelin-1 to endothelin-1.
Biochemistry and molecular biology international 1993;31(5):861-7.
1993: Balwierczak J L; Wong M; Jeng A Y
A simple assay for the measurement of conversion of big endothelin-1 to endothelin-1 by smooth muscle.
European journal of pharmacology 1993;250(3):379-84.
1993: Savage P; Jeng A Y
Quantitation of plasma endothelins.
Analytical biochemistry 1993;213(2):434-6.
1993: Savage P; Shetty S S; Martin L L; Jeng A Y
Conversion of proendothelin-1 into endothelin-1 by aspartylproteases.
International journal of peptide and protein research 1993;42(3):227-32.
1992: Deng Y; Jeng A Y
Soluble endothelin degradation enzyme activities in various rat tissues.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(12):1385-9.
1992: Balwierczak J L; Hopkins M F; Savage P; Martin L L; Jeng A Y
Decrease in immunoreactivity and vasoactivity of endothelin-1 after exposure to oxygen.
Biochemistry international 1992;27(6):1111-7.
1992: Deng Y; Martin L L; DelGrande D; Jeng A Y
A soluble protease identified from rat kidney degrades endothelin-1 but not proendothelin-1.
Journal of biochemistry 1992;112(1):168-72.
1992: Deng Y; Savage P; Shetty S S; Martin L L; Jeng A Y
Identification and partial purification of a thiol endothelin-converting enzyme from porcine aortic endothelial cells.
Journal of biochemistry 1992;111(3):346-51.
1991: Oei H H; Burrier A C; Jeng A Y
5-Amino-4-imidazolecarboxamide riboside raises adenosine in perfused hypoxic rat heart.
European journal of pharmacology 1991;204(1):1-7.
1991: O'Byrne E M; Blancuzzi V; Wilson D; Wong M; Peppard J; Simke J P; Jeng A Y
Effects of indomethacin, triamcinolone, and dexamethasone on recombinant human interleukin-1-induced substance P and prostaglandin E2 levels in rabbit knee joints.
Agents and actions 1991;34(1-2):46-8.
1991: Raychaudhuri A; Colombo C; Pastor G; Wong M; Jeng A Y
Effect of capsaicin on carrageenan-induced inflammation in rat pleurisy and exudate substance P level.
Agents and actions 1991;34(1-2):251-3.
1991: O'Byrne E M; Goldberg R L; Doughty J R; Wong M; Blancuzzi V; Wilson D; Jeng A Y
Interleukin-1-induced cartilage degradation is independent of substance P level in rabbit knees.
Agents and actions 1991;34(1-2):232-4.
1991: Gilligan J P; Lovato S J; Jeng A Y
Modulation of endogenous levels of substance P in rat CNS tissues by N,N-diethyldithiocarbamate.
Annals of the New York Academy of Sciences 1991;632():394-5.
1990: Jeng A Y; Savage P; Soriano A; Balwierczak J L
Different affinities and selectivities of endothelin-1 and endothelin-3 binding to various rat tissues.
Biochemistry international 1990;22(4):669-76.
1990: O'Byrne E M; Blancuzzi V; Wilson D E; Wong M; Jeng A Y
Elevated substance P and accelerated cartilage degradation in rabbit knees injected with interleukin-1 and tumor necrosis factor.
Arthritis and rheumatism 1990;33(7):1023-8.
1990: Jeng A Y; Wong M; Lovato S J; Erion M D; Gilligan J P
A radioimmunoassay for measuring alpha-amidating enzyme activity.
Analytical biochemistry 1990;185(2):213-9.
1990: O'Byrne E M; Blancuzzi V J; Wilson D E; Wong M; Peppard J; Simke J P; Jeng A Y
Increased intra-articular substance P and prostaglandin E2 following injection of interleukin-1 in rabbits.
International journal of tissue reactions 1990;12(1):11-4.
1989: Balwierczak J L; Krulan C M; Wang Z C; Chen J; Jeng A Y
Effects of adenosine A2 receptor agonists on nucleoside transport.
The Journal of pharmacology and experimental therapeutics 1989;251(1):279-87.
1989: Gilligan J P; Lovato S J; Mehta N M; Bertelsen A H; Jeng A Y; Tamburini P P
Multiple forms of peptidyl alpha-amidating enzyme: purification from rat medullary thyroid carcinoma CA-77 cell-conditioned medium.
Endocrinology 1989;124(6):2729-36.
1989: Jeng A Y; Ansell J; Erion M D
pH- and time-dependent inhibition of rat kidney neutral endoprotease 24.11 by thiorphan and phosphoramidon.
Life sciences 1989;45(22):2109-14.
1988: Tamburini P P; Jones B N; Consalvo A P; Young S D; Lovato S J; Gilligan J P; Wennogle L P; Erion M; Jeng A Y
Structure-activity relationships for glycine-extended peptides and the alpha-amidating enzyme derived from medullary thyroid CA-77 cells.
Archives of biochemistry and biophysics 1988;267(2):623-31.
1988: Jones B N; Tamburini P P; Consalvo A P; Young S D; Lovato S J; Gilligan J P; Jeng A Y; Wennogle L P
A fluorometric assay for peptidyl alpha-amidation activity using high-performance liquid chromatography.
Analytical biochemistry 1988;168(2):272-9.
1988: Sonnenberg J L; Sakane Y; Jeng A Y; Koehn J A; Ansell J A; Wennogle L P; Ghai R D
Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney.
Peptides 1988;9(1):173-80.
1988: Wennogle L P; Wysowskyj H E; Jeng A Y
Profiling of inhibitors of protein kinase C.
Advances in enzyme regulation 1988;27():287-93.

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