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Arco Jeng

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Zen-Kong Dai; Chong-Chao Hsieh; Chee-Yin Chai; Jiunn-Ren Wu; Arco Y Jeng; Shah-Hwa Chou; Bin-Nan Wu; Jwu-Lai Yeh; Ing-Jun Chen; Mian-Shin Tan
Protective effects of a dual endothelin converting enzyme/neutral endopeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat.
Aviva Gamliel-Lazarovich; Anna Gantman; Raymond Coleman; Arco Y Jeng; Marielle Kaplan; Shlomo Keidar
FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice.
Christopher M Adams; Chii-Whei Hu; Arco Y Jeng; Rajeshri Karki; Gary Ksander; Dan Lasala; Jennifer Leung-Chu; Guiqing Liang; Qian Liu; Erik Meredith; Chang Rao; Dean F Rigel; Jie Shi; Sherri Smith; Clayton Springer; Chun Zhang
The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.

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2010: Zen-Kong Dai; Chong-Chao Hsieh; Chee-Yin Chai; Jiunn-Ren Wu; Arco Y Jeng; Shah-Hwa Chou; Bin-Nan Wu; Jwu-Lai Yeh; Ing-Jun Chen; Mian-Shin Tan
Protective effects of a dual endothelin converting enzyme/neutral endopeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat.
Pediatric pulmonology 2010;45(11):1076-85.
2010: Aviva Gamliel-Lazarovich; Anna Gantman; Raymond Coleman; Arco Y Jeng; Marielle Kaplan; Shlomo Keidar
FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice.
Journal of hypertension 2010;28(9):1900-7.
2010: Christopher M Adams; Chii-Whei Hu; Arco Y Jeng; Rajeshri Karki; Gary Ksander; Dan Lasala; Jennifer Leung-Chu; Guiqing Liang; Qian Liu; Erik Meredith; Chang Rao; Dean F Rigel; Jie Shi; Sherri Smith; Clayton Springer; Chun Zhang
The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.
Bioorganic & medicinal chemistry letters 2010;20(15):4324-7.
2010: Dean F Rigel; Fumin Fu; Michael Beil; Chii-Whei Hu; Guiqing Liang; Arco Y Jeng
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone.
The Journal of pharmacology and experimental therapeutics 2010;334(1):232-43.
2010: Jessie Gu; Adele Noe; Priya Chandra; Suliman Al-Fayoumi; Monica Ligueros-Saylan; Ramesh Sarangapani; Suzanne Maahs; Gary Ksander; Dean F Rigel; Arco Y Jeng; Tsu-Han Lin; Weiyi Zheng; William P Dole
Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).
Journal of clinical pharmacology 2010;50(4):401-14.
2009: Daniel LaSala; Yasuhiko Shibanaka; Arco Y Jeng
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Analytical biochemistry 2009;394(1):56-61.
2009: Bing S Huang; Roselyn A White; Arco Y Jeng; Frans H H Leenen
Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;296(4):R994-R1000.
2009: Bing S Huang; Roselyn A White; Monir Ahmad; Junhui Tan; Arco Y Jeng; Frans H H Leenen
Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.
Cardiovascular research 2009;81(3):574-81.
2008: Paul Mulder; Virginie Mellin; Julie Favre; Magali Vercauteren; I Remy-Jouet; Christelle Monteil; Vincent RICHARD; Sylvanie Renet; Jean Paul Henry; Arco Y Jeng; Randy L Webb; Christian Thuillez
Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.
European heart journal 2008;29(17):2171-9.
2008: Bing S Huang; Roselyn A White; Monir Ahmad; Arco Y Jeng; Frans H H Leenen
Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(1):R166-72.
2007: Philippe Daull; Arco Y Jeng; Bruno Battistini
Towards triple vasopeptidase inhibitors for the treatment of cardiovascular diseases.
Journal of cardiovascular pharmacology 2007;50(3):247-56.
2007: Chih-Lung Lin; Aij-Lie Kwan; Aaron S Dumont; Yu-feng Henry Su; Neal F Kassell; Chih-Jen Wang; Shu-Chuan Wu; Ching-Ling Kuo; Ching-Shan Huang; Arco Y Jeng; Chin-San Liu
Attenuation of experimental subarachnoid hemorrhage-induced increases in circulating intercellular adhesion molecule-1 and cerebral vasospasm by the endothelin-converting enzyme inhibitor CGS 26303.
Journal of neurosurgery 2007;106(3):442-8.
2007: An-Kuo Chou; Tai-I Chen; William Winardi; Ming-Hong Dai; Shih-Chieh Chen; Shen-Long Howng; Chun Po Yen; Tzu-Kan Lin; Arco Y Jeng; Aij-Lie Kwan
Functional neuroprotective effect of CGS 26303, a dual ECE inhibitor, on ischemic-reperfusion spinal cord injury in rats.
Experimental biology and medicine (Maywood, N.J.) 2007;232(2):214-8.
2006: Chih-Lung Lin; William Winardi; Arco Y Jeng; Aij-Lie Kwan
Endothelin-converting enzyme inhibitors for the treatment of subarachnoid hemorrhage-induced vasospasm.
Neurological research 2006;28(7):721-9.
2006: Aij-Lie Kwan; Chih-Lung Lin; Chun Po Yen; William Winardi; Yu-feng Henry Su; Daniel Winardi; Zen-Kong Dai; Arco Y Jeng; Neal F Kassell; Shen-Long Howng; Chih-Jen Wang
Prevention and reversal of vasospasm and ultrastructural changes in basilar artery by continuous infusion of CGS 35066 following subarachnoid hemorrhage.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):1069-74.
2006: Chih-Lung Lin; Aaron S Dumont; Shu-Chuan Wu; Chih-Jen Wang; Shen-Long Howng; Yan-Fen Huang; Wee-Yen Wong; Neal F Kassell; Arco Y Jeng; Aij-Lie Kwan
17beta-estradiol inhibits endothelin-1 production and attenuates cerebral vasospasm after experimental subarachnoid hemorrhage.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):1054-7.
2006: Shah-Hwa Chou; Chee-Yin Chai; Jiunn-Ren Wu; Mian-Shin Tan; Chaw-Chi Chiu; Ing-Jun Chen; Arco Y Jeng; Chung-I Chang; Aij-Lie Kwan; Zen-Kong Dai
The effects of debanding on the lung expression of ET-1, eNOS, and cGMP in rats with left ventricular pressure overload.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):954-9.
2006: Mian-Shin Tan; Chee-Yin Chai; Jiunn-Ren Wu; Jwu-Lai Yeh; Ing-Jun Chen; Aij-Lie Kwan; Arco Y Jeng; Huey-Yu Yang; Meng-Hsun Lee; Zen-Kong Dai
Differential change in expression of pulmonary ET-1 and eNOS in rats after chronic left ventricular pressure overload.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):948-53.
2006: Zen-Kong Dai; Mian-Shin Tan; Chee-Yin Chai; Shah-Hwa Chou; Pei-Chin Lin; Jwu-Lai Yeh; Arco Y Jeng; Chung-I Chang; Ing-Jun Chen; Jiunn-Ren Wu
Effects of sildenafil on pulmonary hypertension and levels of ET-1, eNOS, and cGMP in aorta-banded rats.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):942-7.
2006: Philippe Daull; André Blouin; Karine Belleville; Myriam Beaudoin; D Arsenault; H Leonard; Pierre Sirois; François Nantel; Arco Y Jeng; Bruno Battistini
Triple VPI CGS 35601 reduces high blood pressure in low-renin, high-salt Dahl salt-sensitive rats.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):830-3.
2006: Philippe Daull; André Blouin; Myriam Beaudoin; S Gadbois; Karine Belleville; Julie Cayer; Nathalie Berthiaume; Pierre Sirois; François Nantel; Arco Y Jeng; Bruno Battistini
The hemodynamic and metabolic profiles of Zucker diabetic fatty rats treated with a single molecule triple vasopeptidase inhibitor, CGS 35601.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):824-9.
2006: Philippe Daull; R Lepage; Ouhida Benrezzak; Julie Cayer; Myriam Beaudoin; Karine Belleville; André Blouin; Pierre Sirois; François Nantel; Arco Y Jeng; Bruno Battistini
The first preclinical pharmacotoxicological safety assessment of CGS 35601, a triple vasopeptidase inhibitor, in chronically instrumented, conscious, and unrestrained spontaneously hypertensive rats.
Drug and chemical toxicology 2006;29(2):183-202.
2005: Philippe Daull; Ouhida Benrezzak; Dominique Arsenault; Leng Hong Pheng; André Blouin; Julie Cayer; Myriam Beaudoin; Karine Belleville; Pierre Sirois; François Nantel; Arco Y Jeng; Bruno Battistini
Triple vasopeptidase inhibition normalizes blood pressure in conscious, unrestrained, and spontaneously hypertensive rats.
American journal of hypertension 2005;18(12 Pt 1):1606-13.
2005: Gary M Coppola; Paivi J Kukkola; James L Stanton; Alan D Neubert; Nicholas Marcopulos; Natalie A Bilci; Hua Wang; Hollis C Tomaselli; Jenny Tan; Thomas D Aicher; Douglas C Knorr; Arco Y Jeng; Beatriz Dardik; Ricardo E Chatelain
Perhydroquinolylbenzamides as novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Journal of medicinal chemistry 2005;48(21):6696-712.
2005: Virginie Mellin; Arco Y Jeng; Christelle Monteil; Sylvanie Renet; Jean-Paul Henry; Christian Thuillez; Paul Mulder
Triple ACE-ECE-NEP inhibition in heart failure: a comparison with ACE and dual ECE-NEP inhibition.
Journal of cardiovascular pharmacology 2005;46(3):390-7.
2005: Anette Fiebeler; Jürg Nussberger; Erdenechimeg Shagdarsuren; Song Rong; Georg Hilfenhaus; Nidal al-Saadi; Ralf Dechend; Maren Wellner; Silke Meiners; Christiane Maser-Gluth; Arco Y Jeng; Randy L Webb; Friedrich C Luft; Dominik N Muller
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Circulation 2005;111(23):3087-94.
2005: Noriaki Emoto; Sunu Budhi Raharjo; Daiji Isaka; Shigeru Masuda; Suko Adiarto; Arco Y Jeng; Mitsuhiro Yokoyama
Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats.
Hypertension 2005;45(6):1145-52.
2005: Bruno Battistini; Philippe Daull; Arco Y Jeng
CGS 35601, a triple inhibitor of angiotensin converting enzyme, neutral endopeptidase and endothelin converting enzyme.
Cardiovascular drug reviews 2005;23(4):317-30.
2004: Chih-Zen Chang; Chun Po Yen; Daniel Winadi; Shu-Chuan Wu; Shen-Long Howng; Tze-Kan Lin; Arco Y Jeng; Neal F Kassell; Aij-Lie Kwan
Neuroprotective effect of CGS 26303, an endothelin-converting enzyme inhibitor, on transient middle cerebral artery occlusion in rats.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S487-9.
2004: Chun Po Yen; Shih-Chieh Chen; Tze-Kan Lin; Shu-Chuan Wu; Chao-Yuah Chang; SI Lue; Arco Y Jeng; Neal F Kassell; Aij-Lie Kwan
CGS 26303 upregulates mRNA expression of heme oxygenase-1 in brain tissue of rats subjected to experimental subarachnoid hemorrhage.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S474-8.
2004: Philippe Daull; André Blouin; Pierre Sirois; François Nantel; Arco Y Jeng; Bruno Battistini
Triple vasopeptidase inhibition of angiotensin-converting enzyme/neutral endopeptidase/endothelin-converting enzyme activities on the hemodynamic profile of chronically instrumented unrestrained conscious spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S398-401.
2004: Bruno Battistini; M Verreault; Bilal Ayach; André Blouin; P Cernacek; Arco Y Jeng; Jerry L Wessale; Terry J Opgenorth; John Tsang
Role of the endothelin system in secondary pulmonary hypertension related to air embolism: lessons learned from testing four classes of endothelin blockers in a rat model.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S386-9.
2004: Zen-Kong Dai; Mian-Shin Tan; Chee-Yin Chai; Ing-Jun Chen; Arco Y Jeng; Aij-Lie Kwan; Shen-Long Howng; Chu-Chong Lu; Jiunn-Ren Wu
Differential changes in endothelin-1 and endothelial nitric oxide synthase gene expression in rats with a chronic high pulmonary flow.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S341-5.
2004: Chii-Whei Hu; Randy L Webb; Arco Y Jeng
Synergistic stimulation of aldosterone production in human adrenocortical carcinoma NCI-H295R cells by endothelin-1 and angiotensin II.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S289-92.
2004: Angelo J Trapani; Michael E Beil; Charles W Bruseo; Paula Savage; Fariborz Firooznia; Arco Y Jeng
CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S211-5.
2004: Jerry W Skiles; Nina C Gonnella; Arco Y Jeng
The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors.
Current medicinal chemistry 2004;11(22):2911-77.
2004: Chih-Lung Lin; Arco Y Jeng; Shen-Long Howng; Aij-Lie Kwan
Endothelin and subarachnoid hemorrhage-induced cerebral vasospasm: pathogenesis and treatment.
Current medicinal chemistry 2004;11(13):1779-91.
2004: Paul Mulder; Stephane Barbier; Christelle Monteil; Arco Y Jeng; Jean-Paul Henry; Sylvanie Renet; Christian Thuillez
Sustained improvement of cardiac function and prevention of cardiac remodeling after long-term dual ECE-NEP inhibition in rats with congestive heart failure.
Journal of cardiovascular pharmacology 2004;43(4):489-94.
2004: Zen-Kong Dai; Mian-Shin Tan; Chee-Yin Chai; Jwu-Lai Yeh; Shah-Hwa Chou; Chaw-Chi Chiu; Arco Y Jeng; Ing-Jun Chen; Jiunn-Ren Wu
Upregulation of endothelial nitric oxide synthase and endothelin-1 in pulmonary hypertension secondary to heart failure in aorta-banded rats.
Pediatric pulmonology 2004;37(3):249-56.
2003: Arco Y Jeng
Utility of endothelin-converting enzyme inhibitors for the treatment of cardiovascular diseases.
Current opinion in investigational drugs (London, England : 2000) 2003;4(9):1076-81.
2003: Anil Raychaudhuri; Mary Chou; Marla Weetall; Arco Y Jeng
Blockade of integrin VLA-4 prevents inflammation and matrix metalloproteinase expression in a murine model of accelerated collagen-induced arthritis.
Inflammation 2003;27(2):107-13.
2002: Fariborz Firooznia; Candido Gude; Kenneth Chan; Jenny Tan; Cynthia A Fink; Paula Savage; Michael E Beil; Charles W Bruseo; Angelo J Trapani; Arco Y Jeng
Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1.
Bioorganic & medicinal chemistry letters 2002;12(21):3059-62.
2002: Chih-Zen Chang; Daniel Winardi; Chih-Lung Lin; Aij-Lie Kwan; Arco Y Jeng; Neal F Kassell; Shen-Long Howng; Kevin S Lee
Attenuation of hemolysate-induced cerebrovascular endothelial cell injury and of production of endothelin-1 and big endothelin-1 by an endothelin-converting enzyme inhibitor.
Surgical neurology 2002;58(3-4):181-7; discussion 187-8.
2002: Aij-Lie Kwan; Chih-Lung Lin; Chih-Zen Chang; Daniel Winardi; Chun Po Yen; Shu-Chuan Wu; Kevin S Lee; Neal F Kassell; Shen-Long Howng; Paula Savage; Arco Y Jeng
Oral administration of an inhibitor of endothelin-converting enzyme attenuates cerebral vasospasm following experimental subarachnoid haemorrhage in rabbits.
Clinical science (London, England : 1979) 2002;103 Suppl 48():414S-417S.
2002: Bilal Ayach; John Tsang; Arco Y Jeng; André Blouin; Mélanie Gosselin; Fu-Hou Wang; J Ruth Wu-Wong; Jerry L Wessale; Terry J Opgenorth; Bruno Battistini
Effects of a selective endothelin A receptor antagonist, ABT-627, in healthy normotensive anaesthetized rats developing acute pulmonary air embolism.
Clinical science (London, England : 1979) 2002;103 Suppl 48():371S-375S.
2002: Bruno Battistini; Bilal Ayach; Stéphanie Molez; André Blouin; Arco Y Jeng
Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats.
Clinical science (London, England : 1979) 2002;103 Suppl 48():363S-366S.
2002: Benjamin A De Campo; Roy G Goldie; Arco Y Jeng; Peter J Henry
Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice.
Clinical science (London, England : 1979) 2002;103 Suppl 48():353S-356S.
2002: Zen-Kong Dai; Mian-Shin Tan; Chee-Yin Chai; Ing-Jun Chen; Arco Y Jeng; Jiunn-Ren Wu
Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat.
Clinical science (London, England : 1979) 2002;103 Suppl 48():289S-293S.
2002: Angelo J Trapani; Michael E Beil; Charles W Bruseo; Cynthia A Fink; Denton Hoyer; Paula Savage; Arco Y Jeng
Effects of the ECE/NEP inhibitor CGS 34225 on the big ET-1-induced pressor response and plasma atrial natriuretic peptide concentration in conscious rats.
Clinical science (London, England : 1979) 2002;103 Suppl 48():102S-106S.
2002: Arco Y Jeng; Paula Savage; Michael E Beil; Charles W Bruseo; Denton Hoyer; Cynthia A Fink; Angelo J Trapani
CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11.
Clinical science (London, England : 1979) 2002;103 Suppl 48():98S-101S.
2002: Raviraj Kulathila; Kirk Clark; Paula Savage; Benjamin R Bowen; Noriaki Emoto; Masashi Yanagisawa; Arco Y Jeng
Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a.
Clinical science (London, England : 1979) 2002;103 Suppl 48():94S-97S.
2002: Paula Savage; Arco Y Jeng
Upregulation of endothelin-1 binding in tissues of salt-loaded stroke-prone spontaneously hypertensive rats.
Canadian journal of physiology and pharmacology 2002;80(5):470-4.
2002: Gary M Ksander; Suraj S Shetty; Dominick DelGrande; Joseph L Balwierczak; Charles W Bruseo; Paula Savage; Reynalda deJesus; Andrew Yuan; Randy L Webb; Arco Y Jeng
Dipeptide sulfonamides as endothelin ETA/ETB receptor antagonists.
Canadian journal of physiology and pharmacology 2002;80(5):464-9.
2002: Dung Pham; Arco Y Jeng; Sylvain Plante; Emanuel Escher; Bruno Battistini
Inhibition of endothelin-converting enzyme for protection against neointimal proliferation following balloon angioplasty of the rat carotid artery.
Canadian journal of physiology and pharmacology 2002;80(5):450-7.
2002: Arco Y Jeng; Paul Mulder; Aij-Lie Kwan; Bruno Battistini
Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications.
Canadian journal of physiology and pharmacology 2002;80(5):440-9.
2002: Aij-Lie Kwan; Chih-Lung Lin; Chih-Zen Chang; Shu-Chuan Wu; Shen-Long Howng; Arco Y Jeng
Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor.
Neuroreport 2002;13(2):197-9.
2002: Chih-Zen Chang; Daniel Winardi; Joon-Khim Loh; S-S Kung; Shen-Long Howng; Arco Y Jeng; Aij-Lie Kwan
Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine.
Acta neurochirurgica 2002;144(2):189-93; discussion 193.
2001: Aij-Lie Kwan; Chih-Lung Lin; Chih-Zen Chang; H J Wu; Shen-Long Hwong; Arco Y Jeng; Kung-Shing Lee
Continuous intravenous infusion of CGS 26303, an endothelin-converting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage.
Neurosurgery 2001;49(2):422-7; discussion 427-9.
2001: P J Kukkola; N A Bilci; T Ikler; Paula Savage; Suraj S Shetty; Dominick DelGrande; Arco Y Jeng
Isoindolines: a new series of potent and selective endothelin-A receptor antagonists.
Bioorganic & medicinal chemistry letters 2001;11(13):1737-40.
2001: J W Skiles; Nina C Gonnella; Arco Y Jeng
The design, structure, and therapeutic application of matrix metalloproteinase inhibitors.
Current medicinal chemistry 2001;8(4):425-74.
2001: Fariborz Firooznia; C Gude; K Chan; Cynthia A Fink; Y Qiao; Y Satoh; N Marcopoulos; Paula Savage; Michael E Beil; Charles W Bruseo; Angelo J Trapani; Arco Y Jeng
Synthesis and biological activity of novel potent endothelin-converting enzyme-1 inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(3):375-8.
2000: DL Feldman; TC Mogelesky; Mary Chou; Arco Y Jeng
Attenuation of puromycin aminonucleoside-induced glomerular lesions in rats by CGS 26303, a dual neutral endopeptidase/endothelin-converting enzyme inhibitor.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S342-5.
2000: DL Feldman; TC Mogelesky; Mary Chou; Arco Y Jeng
Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S255-9.
2000: Aij-Lie Kwan; Chih-Lung Lin; Chih-Zen Chang; Daniel Winardi; Chun Po Yen; Shen-Long Howng; Arco Y Jeng
Effects of endothelin-converting enzyme inhibitors on hemolysate-induced morphological changes and production of endothelin-1 in bovine cerebrovascular endothelial cells.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S160-2.
2000: Angelo J Trapani; Michael E Beil; Charles W Bruseo; Stephane De Lombaert; Arco Y Jeng
Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S40-3.
2000: Arco Y Jeng; Stephane De Lombaert; Michael E Beil; Charles W Bruseo; Paula Savage; Mary Chou; Angelo J Trapani
Design and synthesis of a potent and selective endothelin-converting enzyme inhibitor, CGS 35066.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S36-9.
2000: Cynthia A Fink; MA Moskal; Fariborz Firooznia; Denton Hoyer; D Symonsbergen; D Wei; Y Qiao; Paula Savage; Michael E Beil; Angelo J Trapani; Arco Y Jeng
Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1.
Bioorganic & medicinal chemistry letters 2000;10(17):2037-9.
2000: Stephane De Lombaert; L Blanchard; L B Stamford; Jenny Tan; E M Wallace; Y Satoh; J Fitt; Denton Hoyer; D Simonsbergen; J Moliterni; N Marcopoulos; Paula Savage; Mary Chou; Angelo J Trapani; Arco Y Jeng
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
Journal of medicinal chemistry 2000;43(3):488-504.
2000: Angelo J Trapani; Stephane De Lombaert; Michael E Beil; Charles W Bruseo; Paula Savage; Mary Chou; Arco Y Jeng
CGS 34043: a non-peptidic, potent and long-acting dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11.
Life sciences 2000;67(9):1025-33.
1999: Peter J Henry; MJ Carr; Roy G Goldie; Arco Y Jeng
The role of endothelin in mediating virus-induced changes in endothelinB receptor density in mouse airways.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(1):92-7.
1999: Arco Y Jeng; Mary Chou; WK Sawyer; S L Caplan; J Von Linden-Reed; MR Jeune; M F Prescott
Enhanced expression of matrix metalloproteinase-3, -12, and -13 mRNAs in the aortas of apolipoprotein E-deficient mice with advanced atherosclerosis.
Annals of the New York Academy of Sciences 1999;878():555-8.
1999: M F Prescott; WK Sawyer; J Von Linden-Reed; MR Jeune; Mary Chou; S L Caplan; Arco Y Jeng
Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury.
Annals of the New York Academy of Sciences 1999;878():179-90.
1998: E M Wallace; J A Moliterni; MA Moskal; Alan D Neubert; N Marcopulos; L B Stamford; Angelo J Trapani; Paula Savage; Mary Chou; Arco Y Jeng
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.
Journal of medicinal chemistry 1998;41(9):1513-23.
1998: Arco Y Jeng; Mary Chou; D T Parker
Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase.
Bioorganic & medicinal chemistry letters 1998;8(8):897-902.
1998: Gary M Ksander; Paula Savage; Angelo J Trapani; J L Balwierczak; Arco Y Jeng
Benzofused macrocyclic lactams as triple inhibitors of endothelin-converting enzyme, neutral endopeptidase 24.11, and angiotensin-converting enzyme.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S71-3.
1998: Suraj S Shetty; Paula Savage; Dominick DelGrande; Stephane De Lombaert; Arco Y Jeng
Characterization of CGS 31447, a potent and nonpeptidic endothelin-converting enzyme inhibitor.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S68-70.
1998: Paula Savage; Stephane De Lombaert; K Shimada; K Tanzawa; Arco Y Jeng
Differential inhibition of wild-type endothelin-converting enzyme-1 and its mutants.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S16-8.
1997: Arco Y Jeng; R A Fujimoto; Mary Chou; Jenny Tan; M D Erion
Suppression of substance P biosynthesis in sensory neurons of dorsal root ganglion by prodrug esters of potent peptidylglycine alpha-amidating monooxygenase inhibitors.
The Journal of biological chemistry 1997;272(23):14666-71.
1997: S Hu; H S Kim; P Savage; Arco Y Jeng
Activation of BK(Ca) channel via endothelin ET(A) receptors in porcine coronary artery smooth muscle cells.
European journal of pharmacology 1997;324(2-3):277-82.
1996: C A Fink; J E Carlson; P A McTaggart; Y Qiao; R Webb; R Chatelain; Arco Y Jeng; Angelo J Trapani
Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
Journal of medicinal chemistry 1996;39(16):3158-68.
1995: J L Balwierczak; P J Kukkola; Paula Savage; Arco Y Jeng
Effects of metalloprotease inhibitors on smooth muscle endothelin-converting enzyme activity.
Biochemical pharmacology 1995;49(3):291-6.
1995: Angelo J Trapani; Stephane De Lombaert; S Kuzmich; Arco Y Jeng
Inhibition of big ET-1-induced pressor response by an orally active dual inhibitor of endothelin-converting enzyme and neutral endopeptidase 24.11.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S69-71.
1995: P J Kukkola; Paula Savage; Y Sakane; J C Berry; N A Bilci; R D Ghai; Arco Y Jeng
Differential structure-activity relationships of phosphoramidon analogues for inhibition of three metalloproteases: endothelin-converting enzyme, neutral endopeptidase, and angiotensin-converting enzyme.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S65-8.
1995: J L Balwierczak; C W Bruseo; Dominick DelGrande; Arco Y Jeng; Paula Savage; Suraj S Shetty
Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S393-6.
1995: Suraj S Shetty; Dominick DelGrande; Paula Savage; Gary M Ksander; Arco Y Jeng
Delineation of endothelin receptor subtypes in rat and rabbit aortas.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S310-3.
1995: Arco Y Jeng; M Wong; T Duelfer; S D Shapiro; Richard Kramer; S Hu
Mouse macrophage metalloelastase expressed in bacteria absolutely requires zinc for activity.
Journal of biochemistry 1995;117(1):216-21.
1994: M D Erion; J Tan; M Wong; Arco Y Jeng
Inhibition of peptidylglycine alpha-amidating monooxygenase by N-substituted homocysteine analogs.
Journal of medicinal chemistry 1994;37(26):4430-7.
1994: Stephane De Lombaert; R D Ghai; Arco Y Jeng; Angelo J Trapani; Randy L Webb
Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme.
Biochemical and biophysical research communications 1994;204(1):407-12.
1994: J P Gilligan; S J Lovato; M D Erion; Arco Y Jeng
Modulation of carrageenan-induced hind paw edema by substance P.
Inflammation 1994;18(3):285-92.
1994: A Y Deng; L L Martin; J L Balwierczak; Arco Y Jeng
Purification and characterization of an endothelin degradation enzyme from rat kidney.
Journal of biochemistry 1994;115(1):120-5.
1993: J L Balwierczak; M Wong; Arco Y Jeng
A simple assay for the measurement of conversion of big endothelin-1 to endothelin-1 by smooth muscle.
European journal of pharmacology 1993;250(3):379-84.
1993: Angelo J Trapani; J L Balwierczak; R W Lappe; J L Stanton; S C Graybill; M F Hopkins; Paula Savage; D M Sperbeck; Arco Y Jeng
Effects of metalloprotease inhibitors on the conversion of proendothelin-1 to endothelin-1.
Biochemistry and molecular biology international 1993;31(5):861-7.
1993: P Savage; Arco Y Jeng
Quantitation of plasma endothelins.
Analytical biochemistry 1993;213(2):434-6.
1993: Paula Savage; Suraj S Shetty; L L Martin; Arco Y Jeng
Conversion of proendothelin-1 into endothelin-1 by aspartylproteases.
International journal of peptide and protein research 1993;42(3):227-32.
1992: Y Deng; Arco Y Jeng
Soluble endothelin degradation enzyme activities in various rat tissues.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(12):1385-9.
1992: J L Balwierczak; M F Hopkins; Paula Savage; L L Martin; Arco Y Jeng
Decrease in immunoreactivity and vasoactivity of endothelin-1 after exposure to oxygen.
Biochemistry international 1992;27(6):1111-7.
1992: Y Deng; L L Martin; Dominick DelGrande; Arco Y Jeng
A soluble protease identified from rat kidney degrades endothelin-1 but not proendothelin-1.
Journal of biochemistry 1992;112(1):168-72.
1992: Y Deng; Paula Savage; Suraj S Shetty; L L Martin; Arco Y Jeng
Identification and partial purification of a thiol endothelin-converting enzyme from porcine aortic endothelial cells.
Journal of biochemistry 1992;111(3):346-51.
1991: H H Oei; A C Burrier; Arco Y Jeng
5-Amino-4-imidazolecarboxamide riboside raises adenosine in perfused hypoxic rat heart.
European journal of pharmacology 1991;204(1):1-7.
1991: Elizabeth O'Byrne; Vincent Blancuzzi; D Wilson; M Wong; J Peppard; J P Simke; Arco Y Jeng
Effects of indomethacin, triamcinolone, and dexamethasone on recombinant human interleukin-1-induced substance P and prostaglandin E2 levels in rabbit knee joints.
Agents and actions 1991;34(1-2):46-8.
1991: A Raychaudhuri; C Colombo; G Pastor; M Wong; Arco Y Jeng
Effect of capsaicin on carrageenan-induced inflammation in rat pleurisy and exudate substance P level.
Agents and actions 1991;34(1-2):251-3.
1991: Elizabeth O'Byrne; RL Goldberg; John Doughty; M Wong; Vincent Blancuzzi; D Wilson; Arco Y Jeng
Interleukin-1-induced cartilage degradation is independent of substance P level in rabbit knees.
Agents and actions 1991;34(1-2):232-4.
1991: Arco Y Jeng; P Savage; S Hu
A comparison of the binding of endothelin to various tissues from spontaneously hypertensive and Wistar-Kyoto rats.
Neurochemistry international 1991;18(4):541-6.
1991: J P Gilligan; S J Lovato; Arco Y Jeng
Modulation of endogenous levels of substance P in rat CNS tissues by N,N-diethyldithiocarbamate.
Annals of the New York Academy of Sciences 1991;632():394-5.
1990: Arco Y Jeng; Paula Savage; A Soriano; J L Balwierczak
Different affinities and selectivities of endothelin-1 and endothelin-3 binding to various rat tissues.
Biochemistry international 1990;22(4):669-76.
1990: Elizabeth O'Byrne; Vincent Blancuzzi; D E Wilson; M Wong; Arco Y Jeng
Elevated substance P and accelerated cartilage degradation in rabbit knees injected with interleukin-1 and tumor necrosis factor.
Arthritis and rheumatism 1990;33(7):1023-8.
1990: Arco Y Jeng; M Wong; S J Lovato; M D Erion; J P Gilligan
A radioimmunoassay for measuring alpha-amidating enzyme activity.
Analytical biochemistry 1990;185(2):213-9.
1990: Elizabeth O'Byrne; Vincent Blancuzzi; D E Wilson; M Wong; J Peppard; J P Simke; Arco Y Jeng
Increased intra-articular substance P and prostaglandin E2 following injection of interleukin-1 in rabbits.
International journal of tissue reactions 1990;12(1):11-4.
1989: J L Balwierczak; C M Krulan; Z C Wang; J Chen; Arco Y Jeng
Effects of adenosine A2 receptor agonists on nucleoside transport.
The Journal of pharmacology and experimental therapeutics 1989;251(1):279-87.
1989: J P Gilligan; S J Lovato; N M Mehta; A H Bertelsen; Arco Y Jeng; P P Tamburini
Multiple forms of peptidyl alpha-amidating enzyme: purification from rat medullary thyroid carcinoma CA-77 cell-conditioned medium.
Endocrinology 1989;124(6):2729-36.
1989: Arco Y Jeng; J Ansell; M D Erion
pH- and time-dependent inhibition of rat kidney neutral endoprotease 24.11 by thiorphan and phosphoramidon.
Life sciences 1989;45(22):2109-14.
1988: P P Tamburini; B N Jones; A P Consalvo; S D Young; S J Lovato; J P Gilligan; Lawrence Wennogle; M Erion; Arco Y Jeng
Structure-activity relationships for glycine-extended peptides and the alpha-amidating enzyme derived from medullary thyroid CA-77 cells.
Archives of biochemistry and biophysics 1988;267(2):623-31.
1988: B N Jones; P P Tamburini; A P Consalvo; S D Young; S J Lovato; J P Gilligan; Arco Y Jeng; Lawrence Wennogle
A fluorometric assay for peptidyl alpha-amidation activity using high-performance liquid chromatography.
Analytical biochemistry 1988;168(2):272-9.
1988: Lawrence Wennogle; H E Wysowskyj; Arco Y Jeng
Profiling of inhibitors of protein kinase C.
Advances in enzyme regulation 1988;27():287-93.
1988: J L Sonnenberg; Y Sakane; Arco Y Jeng; J A Koehn; J A Ansell; Lawrence Wennogle; R D Ghai
Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney.
Peptides 1988;9(1):173-80.