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Anders Jensen

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Anders A Jensen; Jacob Krall; Povl Krogsgaard-Larsen; Martin H F Pedersen; Niels Plath; Tine B Stensbøl; Petrine Wellendorph; David E Gloriam; Vignir Isberg; Bente Frølund
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.
Jette G Petersen; Thomas Balle; Rikke Bergmann; Karla Frydenvang; Anders A Jensen; Charlotte G Jørgensen; Jan Kehler; Jesper Kristensen; Uffe Kristiansen; Henriette A Møller; Birgitte Nielsen; Bente Frølund
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists.
Christine A Ussing; Philip K Ahring; Bente Frølund; Michael Gajhede; Camilla P Hansen; Anders A Jensen; Jette S Kastrup; Elsebet Ø Nielsen; Jette G Petersen; Line A H Rohde; Thomas Balle
Synthesis, pharmacology, and biostructural characterization of novel α4β2 nicotinic acetylcholine receptor agonists.

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All Publications

2013: Anders A Jensen; Jacob Krall; Povl Krogsgaard-Larsen; Martin H F Pedersen; Niels Plath; Tine B Stensbøl; Petrine Wellendorph; David E Gloriam; Vignir Isberg; Bente Frølund
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.
Journal of medicinal chemistry 2013;56(3):1211-27.
2013: Jette G Petersen; Thomas Balle; Rikke Bergmann; Karla Frydenvang; Anders A Jensen; Charlotte G Jørgensen; Jan Kehler; Jesper Kristensen; Uffe Kristiansen; Henriette A Møller; Birgitte Nielsen; Bente Frølund
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists.
Journal of medicinal chemistry 2013;56(3):993-1006.
2013: Christine A Ussing; Philip K Ahring; Bente Frølund; Michael Gajhede; Camilla P Hansen; Anders A Jensen; Jette S Kastrup; Elsebet Ø Nielsen; Jette G Petersen; Line A H Rohde; Thomas Balle
Synthesis, pharmacology, and biostructural characterization of novel α4β2 nicotinic acetylcholine receptor agonists.
Journal of medicinal chemistry 2013;56(3):940-51.
2013: Bo Abrahamsen; Lennart Bunch; Mette N Erichsen; Christoph Fahlke; Tri H V Huynh; Nicole Schneider; Anders A Jensen
Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(3):1068-87.
2012: Tri H V Huynh; Anders A Jensen; Karsten K Madsen; Bo Abrahamsen; Alba Gonzalez-Franquesa; Lennart Bunch
Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.
Bioorganic & medicinal chemistry 2012;20(23):6831-9.
2012: Sarah M Trattnig; Louise M Rahr; Sarah B Thygesen; Philip K Ahring; Thomas Balle; Kasper Harpsøe; Anders A Jensen
Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site.
The Journal of biological chemistry 2012;287(30):25241-54.
2012: Tri H V Huynh; Anders A Jensen; Birgitte Nielsen; Irene Shim; Bo Abrahamsen; Henrik Bohr; Lennart Bunch
Structure-activity relationship study of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and absolute configurational assignment using infrared and vibrational circular dichroism spectroscopy in combination with ab initio Hartree-Fock calculations.
Journal of medicinal chemistry 2012;55(11):5403-12.
2011: Charlotte G Jørgensen; Bente Frølund; Jan Kehler; Anders A Jensen
Discovery of benzamide analogues as a novel class of 5-HT₃ receptor agonists.
ChemMedChem 2011;6(4):725-36.
2010: Mette N Erichsen; Tri H V Huynh; Bo Abrahamsen; Jesper F Bastlund; Christoffer Bundgaard; Olja Monrad; Anders Bekker-Jensen; Christina W Nielsen; Karla Frydenvang; Anders A Jensen; Lennart Bunch
Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101).
Journal of medicinal chemistry 2010;53(19):7180-91.
2010: N Krogsgaard-Larsen; Anders A Jensen; Jan Kehler
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.
Bioorganic & medicinal chemistry letters 2010;20(18):5431-3.
2010: Henriette A Møller; Tommy Sander; Jesper L Kristensen; Birgitte Nielsen; Jacob Krall; Marianne L Bergmann; Bolette Christiansen; Thomas Balle; Anders A Jensen; Bente Frølund
Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships.
Journal of medicinal chemistry 2010;53(8):3417-21.
2010: Anders A Jensen; Marianne L Bergmann; Tommy Sander; Thomas Balle
Ginkgolide X is a potent antagonist of anionic Cys-loop receptors with a unique selectivity profile at glycine receptors.
The Journal of biological chemistry 2010;285(13):10141-53.
2009: Lennart Bunch; Darryl S Pickering; Thierry Gefflaut; Virginie Vinatier; Virgil Helaine; Ahmad Amir; Birgitte Nielsen; Anders A Jensen
4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl- (2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters.
ChemMedChem 2009;4(11):1925-9.
2009: Lennart Bunch; Mette N Erichsen; Anders A Jensen
Excitatory amino acid transporters as potential drug targets.
Expert opinion on therapeutic targets 2009;13(6):719-31.
2009: Christopher Armishaw; Anders A Jensen; Thomas Balle; Richard J Clark; Kasper Harpsøe; Christian Skonberg; Tommy Liljefors; Kristian Strømgaard
Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives.
The Journal of biological chemistry 2009;284(14):9498-512.
2009: Trine Kvist; Bolette Christiansen; Anders A Jensen; Hans Bräuner-Osborne
The four human gamma-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay.
Combinatorial chemistry & high throughput screening 2009;12(3):241-9.
2009: Petrine Wellendorph; Lars D. Johansen; Anders A Jensen; Emilio Casanova; Martin Gassmann; Pierre Deprez; Philippe Clément-Lacroix; Bernhard Bettler; Hans Bräuner-Osborne
No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.
Journal of molecular endocrinology 2009;42(3):215-23.
2009: Anders A Jensen; Mette N Erichsen; Christina W Nielsen; Tine B Stensbøl; Jan Kehler; Lennart Bunch
Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.
Journal of medicinal chemistry 2009;52(4):912-5.
2009: Christopher J Armishaw; Anders A Jensen; Christian Skonberg; Tommy Liljefors; Kristian Strømgaard
Synthesis and biological activity of novel alpha-conotoxin analogues incorporating substituted proline derivatives.
Advances in experimental medicine and biology 2009;611():179-80.
2009: Camilla P Hansen; Anders A Jensen; Thomas Balle; Klaus Bitsch-Jensen; Mohamud M Hassan; Tommy Liljefors; Bente Frølund
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC).
Bioorganic & medicinal chemistry letters 2009;19(1):87-91.
2008: Camilla P Hansen; Anders A Jensen; Jeppe K Christensen; Thomas Balle; Tommy Liljefors; Bente Frølund
Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist.
Journal of medicinal chemistry 2008;51(23):7380-95.
2008: Anders A Jensen; Paul Davies; Hans Bräuner-Osborne; Karen Krzywkowski
3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors.
Trends in pharmacological sciences 2008;29(9):437-44.
2008: Simona Colleoni; Anders A Jensen; Elisa Landucci; Elena Fumagalli; Paola Conti; Andrea Pinto; Marco De Amici; Domenico E Pellegrini-Giampietro; Carlo De Micheli; Tiziana Mennini; Marco Gobbi
Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake.
The Journal of pharmacology and experimental therapeutics 2008;326(2):646-56.
2008: Emanuelle Sagot; Anders A Jensen; Darryl S Pickering; Xiaosui Pu; Michelle Umberti; Tine B Stensbøl; Birgitte Nielsen; Zeinab Assaf; Bétina Aboab; Jean Bolte; Thierry Gefflaut; Lennart Bunch
Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2.
Journal of medicinal chemistry 2008;51(14):4085-92.
2008: Karen Krzywkowski; Paul Davies; Paula L Feinberg-Zadek; Hans Bräuner-Osborne; Anders A Jensen
High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):722-7.
2007: Anders A Jensen; Darius P Zlotos; Tommy Liljefors
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.
Journal of medicinal chemistry 2007;50(19):4616-29.
2007: Anders A Jensen; Hans Bräuner-Osborne
Allosteric modulation of the calcium-sensing receptor.
Current neuropharmacology 2007;5(3):180-6.
2007: Anders A Jensen; Thomas Christesen; Ulrik Bølcho; Jeremy R Greenwood; Giovanna Postorino; Stine B Vogensen; Tommy N Johansen; Jan Egebjerg; Hans Bräuner-Osborne; Rasmus P Clausen
Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.
Journal of medicinal chemistry 2007;50(17):4177-85.
2007: Christian Madsen; Anders A Jensen; Tommy Liljefors; Uffe Kristiansen; Birgitte Nielsen; Camilla P Hansen; Mogens Larsen; Bjarke Ebert; Benny Bang-Andersen; Povl Krogsgaard-Larsen; Bente Frølund
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Journal of medicinal chemistry 2007;50(17):4147-61.
2007: Bolette Christiansen; Anne-Kristine Meinild; Anders A Jensen; Hans Braüner-Osborne
Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2.
The Journal of biological chemistry 2007;282(27):19331-41.
2007: Anders A Jensen; Nasreen Begum; Stine B Vogensen; Kolja M Knapp; Klaus Gundertofte; Sergei V Dzyuba; Hideki Ishii; Koji Nakanishi; Uffe Kristiansen; Kristian Strømgaard
Probing the pharmacophore of ginkgolides as glycine receptor antagonists.
Journal of medicinal chemistry 2007;50(7):1610-7.
2007: Karen Krzywkowski; Anders A Jensen; Christopher N Connolly; Hans Bräuner-Osborne
Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression.
Pharmacogenetics and genomics 2007;17(4):255-66.
2007: Hans Bräuner-Osborne; Petrine Wellendorph; Anders A Jensen
Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Current drug targets 2007;8(1):169-84.
2006: Sophie Faure; Anders A Jensen; Vincent Maurat; Xin Gu; Emmanuelle Sagot; David J Aitken; Jean Bolte; Thierry Gefflaut; Lennart Bunch
Stereoselective chemoenzymatic synthesis of the four stereoisomers of l-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3.
Journal of medicinal chemistry 2006;49(22):6532-8.
2006: Anders A Jensen; Parviz Gharagozloo; Nigel J M Birdsall; Darius P Zlotos
Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors.
European journal of pharmacology 2006;539(1-2):27-33.
2006: Mette Strange; Hans Bräuner-Osborne; Anders A Jensen
Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay.
Combinatorial chemistry & high throughput screening 2006;9(2):147-58.
2006: Lennart Bunch; Birgitte Nielsen; Anders A Jensen; Hans Bräuner-Osborne
Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3.
Journal of medicinal chemistry 2006;49(1):172-8.
2005: Sebastien Alaux; Mie Kusk; Emmanuelle Sagot; Jean Bolte; Anders A Jensen; Hans Bräuner-Osborne; Thierry Gefflaut; Lennart Bunch
Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3.
Journal of medicinal chemistry 2005;48(25):7980-92.
2005: Hans Bräuner-Osborne; Lennart Bunch; Nathalie Chopin; François Couty; Gwilherm Evano; Anders A Jensen; Mie Kusk; Birgitte Nielsen; Nicolas Rabasso
Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters.
Organic & biomolecular chemistry 2005;3(21):3926-36.
2005: Anders A Jensen
Functional characterisation of human glycine receptors in a fluorescence-based high throughput screening assay.
European journal of pharmacology 2005;521(1-3):39-42.
2005: Anders A Jensen; Bente Frølund; Tommy Liljefors; Povl Krogsgaard-Larsen
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Journal of medicinal chemistry 2005;48(15):4705-45.
2004: Anders A Jensen; Ivan Mikkelsen; Bente Frølund; Karla Frydenvang; Lotte Brehm; Jerzy W Jaroszewski; Hans Bräuner-Osborne; Erik Falch; Povl Krogsgaard-Larsen
Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors.
European journal of pharmacology 2004;497(2):125-37.
2004: Anne Strømgaard; Anders A Jensen; Kristian Strømgaard
Site-specific incorporation of unnatural amino acids into proteins.
Chembiochem : a European journal of chemical biology 2004;5(7):909-16.
2004: Anders A Jensen; Hans Bräuner-Osborne
Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay.
Biochemical pharmacology 2004;67(11):2115-27.
2004: Anders A Jensen; Uffe Kristiansen
Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay.
Biochemical pharmacology 2004;67(9):1789-99.
2004: Stanislav Jaracz; Koji Nakanishi; Anders A Jensen; Kristian Strømgaard
Ginkgolides and glycine receptors: a structure-activity relationship study.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(6):1507-18.
2004: Anders A Jensen; Tracy A Spalding
Allosteric modulation of G-protein coupled receptors.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;21(4):407-20.
2004: John B Bremner; Colette A Godfrey; Anders A Jensen; Reginald J Smith
Synthesis and nicotinic receptor activity of a hydroxylated tropane.
Bioorganic & medicinal chemistry letters 2004;14(1):271-3.
2003: Anders A Jensen; Ivan Mikkelsen; Bente Frølund; Hans Bräuner-Osborne; Erik Falch; Povl Krogsgaard-Larsen
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.
Molecular pharmacology 2003;64(4):865-75.
2002: Anders A Jensen; Jeremy R Greenwood; Hans Bräuner-Osborne
The dance of the clams: twists and turns in the family C GPCR homodimer.
Trends in pharmacological sciences 2002;23(11):491-3.
2002: Anders A Jensen; Jakob Lerche Hansen; Søren P Sheikh; Hans Bräuner-Osborne
Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET).
European journal of biochemistry / FEBS 2002;269(20):5076-87.
2002: Anders A Jensen; Johannes Mosbacher; Susanne Elg; Kurt Lingenhoehl; Tania Lohmann; Tommy N Johansen; Bjarke Abrahamsen; Jan P Mattsson; Anders Lehmann; Bernhard Bettler; Hans Bräuner-Osborne
The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.
Molecular pharmacology 2002;61(6):1377-84.
2001: Hans Bräuner-Osborne; Anders A Jensen; PO Sheppard; B Brodin; Povl Krogsgaard-Larsen; PJ O'Hara
Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D.
Biochimica et biophysica acta 2001;1518(3):237-48.
2001: Anders A Jensen; B E Madsen; Povl Krogsgaard-Larsen; Hans Bräuner-Osborne
Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor.
European journal of pharmacology 2001;417(3):177-80.
2001: Anders A Jensen; PO Sheppard; L B Jensen; PJ O'Hara; Hans Bräuner-Osborne
Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor.
The Journal of biological chemistry 2001;276(13):10110-8.
2000: Anders A Jensen; Tracy A Spalding; Ethan S Burstein; PO Sheppard; PJ O'Hara; Mark R Brann; Povl Krogsgaard-Larsen; Hans Bräuner-Osborne
Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor.
The Journal of biological chemistry 2000;275(38):29547-55.
2000: Anders A Jensen; PO Sheppard; PJ O'Hara; Povl Krogsgaard-Larsen; Hans Bräuner-Osborne
The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity.
European journal of pharmacology 2000;397(2-3):247-53.
1999: Hans Bräuner-Osborne; Anders A Jensen; P Krogsgaard-Larsen
Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor.
Neuroreport 1999;10(18):3923-5.
1999: Hans Bräuner-Osborne; Anders A Jensen; PO Sheppard; PJ O'Hara; Povl Krogsgaard-Larsen
The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain.
The Journal of biological chemistry 1999;274(26):18382-6.