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Thomas Jentsch

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Guillermo Spitzmaul; Leonardo Tolosa; Beerend H J Winkelman; Christian Chabbert; Chris I De Zeeuw; Maarten A Frens; Matthias Heidenreich; Thomas J Jentsch
Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.
Elena Jeworutzki; Tania López-Hernández; Albert Martínez; Marisol Montolio; Catrin S Müller; Virginia Nunes; Michael Pusch; Uwe Schulte; Sònia Sirisi; Giovanni Zifarelli; Tanit Arnedo; Luiza Bengtsson; Xavier Capdevila-Nortes; Xavier Gasull; Thomas J Jentsch; Raúl Estévez
GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.
Patricia Seja; Guillermo Spitzmaul; william wisden; Ilse Klein; York Rudhard; Martijn Schonewille; Aleksandra Badura; Chris I De Zeeuw; Christian A Hübner; Thomas J Jentsch
Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.

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2013: Guillermo Spitzmaul; Leonardo Tolosa; Beerend H J Winkelman; Christian Chabbert; Chris I De Zeeuw; Maarten A Frens; Matthias Heidenreich; Thomas J Jentsch
Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.
The Journal of biological chemistry 2013;288(13):9334-44.
2012: Elena Jeworutzki; Tania López-Hernández; Albert Martínez; Marisol Montolio; Catrin S Müller; Virginia Nunes; Michael Pusch; Uwe Schulte; Sònia Sirisi; Giovanni Zifarelli; Tanit Arnedo; Luiza Bengtsson; Xavier Capdevila-Nortes; Xavier Gasull; Thomas J Jentsch; Raúl Estévez
GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.
Neuron 2012;73(5):951-61.
2012: Patricia Seja; Guillermo Spitzmaul; william wisden; Ilse Klein; York Rudhard; Martijn Schonewille; Aleksandra Badura; Chris I De Zeeuw; Christian A Hübner; Thomas J Jentsch
Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.
The EMBO journal 2012;31(5):1217-30.
2011: Lilia Leisle; Carmen F Ludwig; Florian A Wagner; Thomas J Jentsch; Tobias Stauber
ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity.
The EMBO journal 2011;30(11):2140-52.
2010: Thomas J Jentsch; Tanja Maritzen; Damien J Keating; Anselm A Zdebik; Frank Thévenod
ClC-3--a granular anion transporter involved in insulin secretion?
Cell metabolism 2010;12(4):307-8; author reply 309-10.
2010: Gaia Novarino; Stefanie Weinert; Gesa Rickheit; Thomas J Jentsch
Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
Science (New York, N.Y.) 2010;328(5984):1398-401.
2010: Stefanie Weinert; Sabrina Jabs; Chayarop Supanchart; Michaela Schweizer; Niclas Gimber; Martin Richter; Jörg Rademann; Tobias Stauber; Uwe Kornak; Thomas J Jentsch
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
Science (New York, N.Y.) 2010;328(5984):1401-3.
2010: Anastassios V Tzingounis; Matthias Heidenreich; Tatjana Kharkovets; Guillermo Spitzmaul; Henrik Sindal Jensen; Roger A Nicoll; Thomas J Jentsch
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(22):10232-7.
2009: Lena Wartosch; Jens C Fuhrmann; Michaela Schweizer; Tobias Stauber; Thomas J Jentsch
Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(12):4056-68.
2009: Anselm A Zdebik; Philine Wangemann; Thomas J Jentsch
Potassium ion movement in the inner ear: insights from genetic disease and mouse models.
Physiology (Bethesda, Md.) 2009;24():307-16.
2009: Thomas J Jentsch
To the editor. CLC chloride channels and transporters: from genes to protein structure, pathology and physiology.
Critical reviews in biochemistry and molecular biology 2009;44(2-3):64.
2009: Vanessa Plans; Gesa Rickheit; Thomas J Jentsch
Physiological roles of CLC Cl(-)/H (+) exchangers in renal proximal tubules.
Pflügers Archiv : European journal of physiology 2009;458(1):23-37.
2009: Eun-Yeong Bergsdorf; Anselm A Zdebik; Thomas J Jentsch
Residues important for nitrate/proton coupling in plant and mammalian CLC transporters.
The Journal of biological chemistry 2009;284(17):11184-93.
2009: Carsten K Pfeffer; Valentin Stein; Damien J Keating; Hannes Maier; Ilka Rinke; York Rudhard; Moritz Hentschke; Gabriele M Rune; Thomas J Jentsch; Christian A Hübner
NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(11):3419-30.
2008: Gesa Rickheit; Hannes Maier; Nicola Strenzke; Corina E Andreescu; Chris I De Zeeuw; Adrian Muenscher; Anselm A Zdebik; Thomas J Jentsch
Endocochlear potential depends on Cl- channels: mechanism underlying deafness in Bartter syndrome IV.
The EMBO journal 2008;27(21):2907-17.
2008: Tanja Maritzen; Damien J Keating; Ioana Neagoe; Anselm A Zdebik; Thomas J Jentsch
Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(42):10587-98.
2008: Anselm A Zdebik; Giovanni Zifarelli; Eun-Yeong Bergsdorf; Paolo Soliani; Olaf Scheel; Thomas J Jentsch; Michael Pusch
Determinants of anion-proton coupling in mammalian endosomal CLC proteins.
The Journal of biological chemistry 2008;283(7):4219-27.
2008: Thomas J Jentsch
CLC chloride channels and transporters: from genes to protein structure, pathology and physiology.
Critical reviews in biochemistry and molecular biology 2008;43(1):3-36.
2007: Judith Blanz; Michaela Schweizer; Muriel Auberson; Hannes Maier; Adrian Muenscher; Christian A Hübner; Thomas J Jentsch
Leukoencephalopathy upon disruption of the chloride channel ClC-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(24):6581-9.
2007: Marco B Rust; Seth L Alper; York Rudhard; Boris E Shmukler; Rubén Vicente; Carlo Brugnara; Marie Trudel; Thomas J Jentsch; Christian A Hübner
Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
The Journal of clinical investigation 2007;117(6):1708-17.
2006: Mallorie Poët; Uwe Kornak; Michaela Schweizer; Anselm A Zdebik; Olaf Scheel; Sabine Hoelter; Wolfgang Wurst; Anja Schmitt; Jens C Fuhrmann; Rosa Planells-Cases; Sara E Mole; Christian A Hübner; Thomas J Jentsch
Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13854-9.
2006: Tanja Maritzen; G Rickheit; A Schmitt; Thomas J Jentsch
Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice.
Kidney international 2006;70(1):79-87.
2006: Michael Schwake; Despina Athanasiadu; Christian Beimgraben; Judith Blanz; Christian Beck; Thomas J Jentsch; Paul Saftig; Thomas Friedrich
Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3757-66.
2006: Philipp F Lange; Lena Wartosch; Thomas J Jentsch; Jens C Fuhrmann
ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function.
Nature 2006;440(7081):220-3.
2006: Marco B Rust; Jörg Faulhaber; Mareike K Budack; Carsten Pfeffer; Tanja Maritzen; Michael Didié; Franz-Xaver Beck; Thomas Boettger; Rudolf Schubert; Heimo Ehmke; Thomas J Jentsch; Christian A Hübner
Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3.
Circulation research 2006;98(4):549-56.
2006: Tatjana Kharkovets; Karin Dedek; Hannes Maier; Michaela Schweizer; Darina Khimich; Régis Nouvian; Vitya Vardanyan; Rudolf Leuwer; Tobias Moser; Thomas J Jentsch
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.
The EMBO journal 2006;25(3):642-52.
2005: Thomas J Jentsch; Tanja Maritzen; Anselm A Zdebik
Chloride channel diseases resulting from impaired transepithelial transport or vesicular function.
The Journal of clinical investigation 2005;115(8):2039-46.
2005: Olaf Scheel; Anselm A Zdebik; Stéphane Lourdel; Thomas J Jentsch
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins.
Nature 2005;436(7049):424-7.
2005: Thomas J Jentsch; Ioana Neagoe; Olaf Scheel
CLC chloride channels and transporters.
Current opinion in neurobiology 2005;15(3):319-25.
2005: Thomas J Jentsch
Chloride transport in the kidney: lessons from human disease and knockout mice.
Journal of the American Society of Nephrology : JASN 2005;16(6):1549-61.
2005: Anne Schenzer; Thomas Friedrich; Michael Pusch; Paul Saftig; Thomas J Jentsch; Joachim Grötzinger; Michael Schwake
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(20):5051-60.
2005: Dagmar Kasper; Rosa Planells-Cases; Jens C Fuhrmann; Olaf Scheel; Oliver Zeitz; Klaus Ruether; Anja Schmitt; Mallorie Poët; Robert Steinfeld; Michaela Schweizer; Uwe Kornak; Thomas J Jentsch
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration.
The EMBO journal 2005;24(5):1079-91.
2005: Thomas J Jentsch; Mallorie Poët; Jens C Fuhrmann; Anselm A Zdebik
Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models.
Annual review of physiology 2005;67():779-807.
2004: Thomas J Jentsch; Christian A Hübner; Jens C Fuhrmann
Ion channels: function unravelled by dysfunction.
Nature cell biology 2004;6(11):1039-47.
2004: Stephan M Huber; Christophe Duranton; Guido Henke; Claudia Van De Sand; Volker T Heussler; Ekaterina Shumilina; Ciprian D Sandu; Valerie Tanneur; Verena B Brand; Ravi S Kasinathan; Karl S Lang; Song Le; Christian A Hübner; Marco B Rust; Karin Dedek; Thomas J Jentsch; Florian Lang
Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte.
The Journal of biological chemistry 2004;279(40):41444-52.
2004: Raúl Estévez; Michael Pusch; Carles Ferrer-Costa; Modesto Orozco; Thomas J Jentsch
Functional and structural conservation of CBS domains from CLC chloride channels.
The Journal of physiology 2004;557(Pt 2):363-78.
2004: Anselm A Zdebik; John E Cuffe; Marko Bertog; Christoph Korbmacher; Thomas J Jentsch
Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models.
The Journal of biological chemistry 2004;279(21):22276-83.
2004: Valentin Stein; Irm Hermans-Borgmeyer; Thomas J Jentsch; Christian A Hübner
Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride.
The Journal of comparative neurology 2004;468(1):57-64.
2003: Thomas Boettger; Marco B Rust; Hannes Maier; Thomas Seidenbecher; Michaela Schweizer; Damien J Keating; Jörg Faulhaber; Heimo Ehmke; Carsten Pfeffer; Olaf Scheel; Beate Lemcke; Jürgen Horst; Rudolf Leuwer; Hans-Christian Pape; Harald Völkl; Christian A Hübner; Thomas J Jentsch
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.
The EMBO journal 2003;22(20):5422-34.
2003: Raúl Estévez; Björn C Schroeder; Alessio Accardi; Thomas J Jentsch; Michael Pusch
Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.
Neuron 2003;38(1):47-59.
2003: Willy Günther; Nils Piwon; Thomas J Jentsch
The ClC-5 chloride channel knock-out mouse - an animal model for Dent's disease.
Pflügers Archiv : European journal of physiology 2003;445(4):456-62.
2003: Michael Schwake; Thomas J Jentsch; Thomas Friedrich
A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.
EMBO reports 2003;4(1):76-81.
2002: Christian A Hübner; Thomas J Jentsch
Ion channel diseases.
Human molecular genetics 2002;11(20):2435-45.
2002: Raúl Estévez; Thomas J Jentsch
CLC chloride channels: correlating structure with function.
Current opinion in structural biology 2002;12(4):531-9.
2002: Thomas Boettger; Christian A Hübner; Hannes Maier; Marco B Rust; Franz X Beck; Thomas J Jentsch
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.
Nature 2002;416(6883):874-8.
2002: Thomas J Jentsch; Valentin Stein; Frank Weinreich; Anselm A Zdebik
Molecular structure and physiological function of chloride channels.
Physiological reviews 2002;82(2):503-68.
2001: Raúl Estévez; Thomas Boettger; Valentin Stein; Ralf Birkenhäger; Edgar Otto; Friedhelm Hildebrandt; Thomas J Jentsch
Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.
Nature 2001;414(6863):558-61.
2001: Karin Dedek; B Kunath; Colette Kananura; Ulrike Reuner; Thomas J Jentsch; Ortrud K Steinlein
Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12272-7.
2001: Regina C Betz; Benedikt Schoser; D Kasper; Kenneth Ricker; A Ramírez; Valentin Stein; Torberg Torbergsen; YA Lee; Markus M Nöthen; Thomas F Wienker; Jean-Pierre Malin; Peter Propping; A Reis; Wilhelm Mortier; Thomas J Jentsch; Matthias Vorgerd; Christian Kubisch
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.
Nature genetics 2001;28(3):218-9.
2001: Christian A Hübner; Valentin Stein; Irm Hermans-Borgmeyer; T Meyer; K Ballanyi; Thomas J Jentsch
Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.
Neuron 2001;30(2):515-24.
2001: Michael Schwake; Thomas Friedrich; Thomas J Jentsch
An internalization signal in ClC-5, an endosomal Cl-channel mutated in dent's disease.
The Journal of biological chemistry 2001;276(15):12049-54.
2001: Michael R Bösl; Valentin Stein; Christian A Hübner; Anselm A Zdebik; SE Jordt; Amal K Mukhopadhyay; Michail S Davidoff; Adolf F Holstein; Thomas J Jentsch
Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.
The EMBO journal 2001;20(6):1289-99.
2001: Alain Vandewalle; Françoise Cluzeaud; KC Peng; Marcelle Bens; A Lüchow; Willy Günther; Thomas J Jentsch
Tissue distribution and subcellular localization of the ClC-5 chloride channel in rat intestinal cells.
American journal of physiology. Cell physiology 2001;280(2):C373-81.
2001: Uwe Kornak; D Kasper; Michael R Bösl; E Kaiser; Michaela Schweizer; A Schulz; W Friedrich; G Delling; Thomas J Jentsch
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man.
Cell 2001;104(2):205-15.
2001: Frank Weinreich; Thomas J Jentsch
Pores formed by single subunits in mixed dimers of different CLC chloride channels.
The Journal of biological chemistry 2001;276(4):2347-53.
2001: S M Stobrawa; T Breiderhoff; S Takamori; Dominique Engel; Michaela Schweizer; Anselm A Zdebik; Michael R Bösl; Klaus Ruether; H Jahn; Andreas Draguhn; R Jahn; Thomas J Jentsch
Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.
Neuron 2001;29(1):185-96.
2000: N Piwon; Willy Günther; Michael Schwake; Michael R Bösl; Thomas J Jentsch
ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.
Nature 2000;408(6810):369-73.
2000: Thomas J Jentsch
Neuronal KCNQ potassium channels: physiology and role in disease.
Nature reviews. Neuroscience 2000;1(1):21-30.
2000: Uwe Kornak; A Schulz; W Friedrich; S Uhlhaas; Bernhard Kremens; T Voit; Carola Hasan; Udo Bode; Thomas J Jentsch; Christian Kubisch
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis.
Human molecular genetics 2000;9(13):2059-63.
2000: Siegfried Waldegger; Thomas J Jentsch
Functional and structural analysis of ClC-K chloride channels involved in renal disease.
The Journal of biological chemistry 2000;275(32):24527-33.
2000: Björn C Schroeder; M Hechenberger; Frank Weinreich; Christian Kubisch; Thomas J Jentsch
KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents.
The Journal of biological chemistry 2000;275(31):24089-95.
2000: Thomas J Jentsch; Björn C Schroeder; Christian Kubisch; Thomas Friedrich; Valentin Stein
Pathophysiology of KCNQ channels: neonatal epilepsy and progressive deafness.
Epilepsia 2000;41(8):1068-9.
2000: Siegfried Waldegger; Thomas J Jentsch
From tonus to tonicity: physiology of CLC chloride channels.
Journal of the American Society of Nephrology : JASN 2000;11(7):1331-9.
2000: Frank Weinreich; Thomas J Jentsch
Neurological diseases caused by ion-channel mutations.
Current opinion in neurobiology 2000;10(3):409-15.
2000: Michael Schwake; Michael Pusch; Tatjana Kharkovets; Thomas J Jentsch
Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy.
The Journal of biological chemistry 2000;275(18):13343-8.
2000: Tatjana Kharkovets; Jean-Pierre Hardelin; Saaid Safieddine; Michaela Schweizer; Aziz El-Amraoui; Christine Petit; Thomas J Jentsch
KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4333-8.
2000: Björn C Schroeder; Siegfried Waldegger; Susanne Fehr; M Bleich; Richard Warth; R Greger; Thomas J Jentsch
A constitutively open potassium channel formed by KCNQ1 and KCNE3.
Nature 2000;403(6766):196-9.
1999: A M Schriever; Thomas Friedrich; Michael Pusch; Thomas J Jentsch
CLC chloride channels in Caenorhabditis elegans.
The Journal of biological chemistry 1999;274(48):34238-44.
1999: Thomas J Jentsch; T Friedrich; A Schriever; H Yamada
The CLC chloride channel family.
Pflügers Archiv : European journal of physiology 1999;437(6):783-95.
1999: Michael Pusch; SE Jordt; Valentin Stein; Thomas J Jentsch
Chloride dependence of hyperpolarization-activated chloride channel gates.
The Journal of physiology 1999;515 ( Pt 2)():341-53.
1999: Christian Kubisch; Björn C Schroeder; Thomas Friedrich; B Lütjohann; Aziz El-Amraoui; S Marlin; Christine Petit; Thomas J Jentsch
KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.
Cell 1999;96(3):437-46.
1999: Thomas Friedrich; T Breiderhoff; Thomas J Jentsch
Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents.
The Journal of biological chemistry 1999;274(2):896-902.
1998: Björn C Schroeder; Christian Kubisch; Valentin Stein; Thomas J Jentsch
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.
Nature 1998;396(6712):687-90.
1998: Ortrud K Steinlein; Thomas J Jentsch
KCNQ2, the first gene found to be mutated in human generalized idiopathic epilepsy.
Pathologie-biologie 1998;46(9):683-4.
1998: Christian Kubisch; T Schmidt-Rose; B Fontaine; Allan H Bretag; Thomas J Jentsch
ClC-1 chloride channel mutations in myotonia congenita: variable penetrance of mutations shifting the voltage dependence.
Human molecular genetics 1998;7(11):1753-60.
1998: Klaus Steinmeyer; Thomas J Jentsch
Molecular physiology of renal chloride channels.
Current opinion in nephrology and hypertension 1998;7(5):497-502.
1998: Willy Günther; A Lüchow; Françoise Cluzeaud; Alain Vandewalle; Thomas J Jentsch
ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8075-80.
1998: Blanche Schwappach; S Stobrawa; M Hechenberger; Klaus Steinmeyer; Thomas J Jentsch
Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p.
The Journal of biological chemistry 1998;273(24):15110-8.
1998: Grigori Y Rychkov; M Pusch; Michael L Roberts; Thomas J Jentsch; Allan H Bretag
Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions.
The Journal of general physiology 1998;111(5):653-65.
1998: P Fong; A Rehfeldt; Thomas J Jentsch
Determinants of slow gating in ClC-0, the voltage-gated chloride channel of Torpedo marmorata.
The American journal of physiology 1998;274(4 Pt 1):C966-73.
1998: S Clark; SE Jordt; Thomas J Jentsch; Alistair Mathie
Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons.
The Journal of physiology 1998;506 ( Pt 3)():665-78.
1998: C Biervert; Björn C Schroeder; Christian Kubisch; SF Berkovic; Peter Propping; Thomas J Jentsch; Ortrud K Steinlein
A potassium channel mutation in neonatal human epilepsy.
Science (New York, N.Y.) 1998;279(5349):403-6.
1997: Bernd Wollnik; Björn C Schroeder; Christian Kubisch; H D Esperer; P Wieacker; Thomas J Jentsch
Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias.
Human molecular genetics 1997;6(11):1943-9.
1997: T Schmidt-Rose; Thomas J Jentsch
Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1.
The Journal of biological chemistry 1997;272(33):20515-21.
1997: U Ludewig; Michael Pusch; Thomas J Jentsch
Independent gating of single pores in CLC-0 chloride channels.
Biophysical journal 1997;73(2):789-97.
1997: U Ludewig; Thomas J Jentsch; Michael Pusch
Inward rectification in ClC-0 chloride channels caused by mutations in several protein regions.
The Journal of general physiology 1997;110(2):165-71.
1997: T Schmidt-Rose; Thomas J Jentsch
Transmembrane topology of a CLC chloride channel.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7633-8.
1997: A Vandewalle; Françoise Cluzeaud; Marcelle Bens; S Kieferle; Klaus Steinmeyer; Thomas J Jentsch
Localization and induction by dehydration of ClC-K chloride channels in the rat kidney.
The American journal of physiology 1997;272(5 Pt 2):F678-88.
1997: SE Jordt; Thomas J Jentsch
Molecular dissection of gating in the ClC-2 chloride channel.
The EMBO journal 1997;16(7):1582-92.
1997: U Ludewig; Thomas J Jentsch; Michael Pusch
Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0.
The Journal of physiology 1997;498 ( Pt 3)():691-702.
1997: Thomas J Jentsch; Willy Günther
Chloride channels: an emerging molecular picture.
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(2):117-26.
1997: Michael Pusch; U Ludewig; Thomas J Jentsch
Temperature dependence of fast and slow gating relaxations of ClC-0 chloride channels.
The Journal of general physiology 1997;109(1):105-16.
1996: M Hechenberger; B Schwappach; Wolf N Fischer; Wolf Frommer; Thomas J Jentsch; Klaus Steinmeyer
A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption.
The Journal of biological chemistry 1996;271(52):33632-8.
1996: Grigori Y Rychkov; Michael Pusch; D S Astill; Michael L Roberts; Thomas J Jentsch; Allan H Bretag
Concentration and pH dependence of skeletal muscle chloride channel ClC-1.
The Journal of physiology 1996;497 ( Pt 2)():423-35.
1996: C Lorenz; Michael Pusch; Thomas J Jentsch
Heteromultimeric CLC chloride channels with novel properties.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13362-6.
1996: U Ludewig; Michael Pusch; Thomas J Jentsch
Two physically distinct pores in the dimeric ClC-0 chloride channel.
Nature 1996;383(6598):340-3.
1996: SE Lloyd; SH Pearce; Simon E Fisher; Klaus Steinmeyer; B Schwappach; Steven J Scheinman; Brian Harding; Alessandra Bolino; M Devoto; Paul Goodyer; S P Rigden; Oliver Wrong; Thomas J Jentsch; IW Craig; Rajesh V Thakker
A common molecular basis for three inherited kidney stone diseases.
Nature 1996;379(6564):445-9.
1995: Klaus Steinmeyer; B Schwappach; Marcelle Bens; Alain Vandewalle; Thomas J Jentsch
Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease.
The Journal of biological chemistry 1995;270(52):31172-7.
1995: Michael Pusch; Klaus Steinmeyer; Manuela C Koch; Thomas J Jentsch
Mutations in dominant human myotonia congenita drastically alter the voltage dependence of the CIC-1 chloride channel.
Neuron 1995;15(6):1455-63.
1995: C Meyer-Kleine; Klaus Steinmeyer; Kenneth Ricker; Thomas J Jentsch; Manuela C Koch
Spectrum of mutations in the major human skeletal muscle chloride channel gene (CLCN1) leading to myotonia.
American journal of human genetics 1995;57(6):1325-34.
1995: Andreas Lengeling; M Gronemeier; Melanie Ronsiek; A Thiemann; Thomas J Jentsch; Harald Jockusch
Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q.
Genetical research 1995;66(2):175-8.
1995: P Fong; Thomas J Jentsch
Molecular basis of epithelial Cl channels.
The Journal of membrane biology 1995;144(3):189-97.
1995: Michael Pusch; U Ludewig; A Rehfeldt; Thomas J Jentsch
Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.
Nature 1995;373(6514):527-31.
1995: Thomas J Jentsch; W Günther; Michael Pusch; B Schwappach
Properties of voltage-gated chloride channels of the ClC gene family.
The Journal of physiology 1995;482():19S-25S.
1995: Thomas J Jentsch; C Lorenz; Michael Pusch; Klaus Steinmeyer
Myotonias due to CLC-1 chloride channel mutations.
Society of General Physiologists series 1995;50():149-59.
1994: R Klocke; Klaus Steinmeyer; Thomas J Jentsch; Harald Jockusch
Role of innervation, excitability, and myogenic factors in the expression of the muscular chloride channel ClC-1. A study on normal and myotonic muscle.
The Journal of biological chemistry 1994;269(44):27635-9.
1994: Michael Pusch; Thomas J Jentsch
Molecular physiology of voltage-gated chloride channels.
Physiological reviews 1994;74(4):813-27.
1994: S Kieferle; P Fong; Marcelle Bens; Alain Vandewalle; Thomas J Jentsch
Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):6943-7.
1994: C Lorenz; C Meyer-Kleine; Klaus Steinmeyer; Manuela C Koch; Thomas J Jentsch
Genomic organization of the human muscle chloride channel CIC-1 and analysis of novel mutations leading to Becker-type myotonia.
Human molecular genetics 1994;3(6):941-6.
1994: M Gronemeier; A Condie; J Prosser; Klaus Steinmeyer; Thomas J Jentsch; Harald Jockusch
Nonsense and missense mutations in the muscular chloride channel gene Clc-1 of myotonic mice.
The Journal of biological chemistry 1994;269(8):5963-7.
1994: Klaus Steinmeyer; C Lorenz; Michael Pusch; Manuela C Koch; Thomas J Jentsch
Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).
The EMBO journal 1994;13(4):737-43.
1994: Michael Pusch; Klaus Steinmeyer; Thomas J Jentsch
Low single channel conductance of the major skeletal muscle chloride channel, ClC-1.
Biophysical journal 1994;66(1):149-52.
1994: Thomas J Jentsch
Structure and function of ClC chloride channels.
The Japanese journal of physiology 1994;44 Suppl 2():S1-2.
1993: Thomas J Jentsch; Michael Pusch; A Rehfeldt; Klaus Steinmeyer
The ClC family of voltage-gated chloride channels: structure and function.
Annals of the New York Academy of Sciences 1993;707():285-93.
1993: Manuela C Koch; Kenneth Ricker; M Otto; F Wolf; B Zoll; C Lorenz; Klaus Steinmeyer; Thomas J Jentsch
Evidence for genetic homogeneity in autosomal recessive generalised myotonia (Becker).
Journal of medical genetics 1993;30(11):914-7.
1992: S Gründer; A Thiemann; Michael Pusch; Thomas J Jentsch
Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume.
Nature 1992;360(6406):759-62.
1992: Manuela C Koch; Klaus Steinmeyer; C Lorenz; Kenneth Ricker; F Wolf; M Otto; B Zoll; F Lehmann-Horn; Karl-Heinz Grzeschik; Thomas J Jentsch
The skeletal muscle chloride channel in dominant and recessive human myotonia.
Science (New York, N.Y.) 1992;257(5071):797-800.
1992: A Thiemann; S Gründer; Michael Pusch; Thomas J Jentsch
A chloride channel widely expressed in epithelial and non-epithelial cells.
Nature 1992;356(6364):57-60.
1991: Christiane K Bauer; Klaus Steinmeyer; Jürgen R Schwarz; Thomas J Jentsch
Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11052-6.
1991: Klaus Steinmeyer; R Klocke; C Ortland; M Gronemeier; Harald Jockusch; S Gründer; Thomas J Jentsch
Inactivation of muscle chloride channel by transposon insertion in myotonic mice.
Nature 1991;354(6351):304-8.
1991: Klaus Steinmeyer; C Ortland; Thomas J Jentsch
Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel.
Nature 1991;354(6351):301-4.
1990: Thomas J Jentsch; Klaus Steinmeyer; G Schwarz
Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.
Nature 1990;348(6301):510-4.