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Donald Jerina
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63
Yagi, Haruhiko
59
Sayer, Jane
37
Conney, Allan
34
Chang, Richard
19
Kroth, Heiko
18
Dipple, Anthony
9
Cui, Xiao-Xing
9
Wei, SJ
8
Pommier, Yves
8
Huang, Mou-Tuan
7
Yeh, Herman
6
Zajc, Barbara
6
Kalena, Govind
6
Gorenstein, David
5
Kohlhagen, Glenda
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All Publications
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2008: Yagi Haruhiko; Frank Heinrich; Seidel Albrecht; Jerina Donald M
Revised assignment of absolute configuration of the cis- and trans-N6-deoxyadenosine adducts at C14 of (+/-)-11beta,12alpha-dihydroxy-13alpha,14alpha-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene by stereoselective synthesis.
Chemical research in toxicology 2008;21(12):2379-92.
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2008: Wang Yazhen; Schnetz-Boutaud Nathalie C; Kroth Heiko; Yagi Haruhiko; Sayer Jane M; Kumar Subodh; Jerina Donald M; Stone Michael P
3'-Intercalation of a N2-dG 1R-trans-anti-benzo[c]phenanthrene DNA adduct in an iterated (CG)3 repeat.
Chemical research in toxicology 2008;21(7):1348-58.
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2007: Yagi Haruhiko; Jerina Donald M
Fluorinated alcohol mediated displacement of the C10 acetoxy group of benzo[a]pyrene-7,8,9,10-tetrahydrotetraol tetraacetates: a new route to diol epoxide-deoxyguanosine adducts.
The Journal of organic chemistry 2007;72(26):9983-90.
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2007: Bauer Jacob; Xing Guangxin; Yagi Haruhiko; Sayer Jane M; Jerina Donald M; Ling Hong
A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):14905-10.
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2007: Yagi Haruhiko; Jerina Donald M
Fluorinated alcohol mediated control over cis vs trans opening of benzo[a]pyrene-7,8-diol 9,10-epoxides at C-10 by the exocyclic amino groups of O6-allyl protected deoxyguanosine and of deoxyadenosine.
The Journal of organic chemistry 2007;72(16):6037-45.
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2007: Yagi Haruhiko; Frank Heinrich; Seidel Albrecht; Jerina Donald M
Synthesis and absolute configuration of cis- and trans-opened cyclopenta[cd]pyrene 3,4-oxide N2-deoxyguanosine adducts: conversion to phosphoramidites for oligonucleotide synthesis.
Chemical research in toxicology 2007;20(4):650-61.
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2007: Iyer Prema C; Yagi Haruhiko; Sayer Jane M; Jerina Donald M
3'-H-phosphonate synthesis of chiral benzo[a]pyrene diol epoxide adducts at N(2) of deoxyguanosine in oligonucleotides.
Chemical research in toxicology 2007;20(2):311-5.
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2006: Batra Vinod K; Shock David D; Prasad Rajendra; Beard William A; Hou Esther W; Pedersen Lars C; Sayer Jane M; Yagi Haruhiko; Kumar Subodh; Jerina Donald M; Wilson Samuel H
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17231-6.
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2006: Johnson Allison A; Sayer Jane M; Yagi Haruhiko; Patil Sachindra S; Debart Françoise; Maier Martin A; Corey David R; Vasseur Jean-Jacques; Burke Terrence R; Marquez Victor E; Jerina Donald M; Pommier Yves
Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
The Journal of biological chemistry 2006;281(43):32428-38.
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2006: Wang Ben; Sayer Jane M; Yagi Haruhiko; Frank Heinrich; Seidel Albrecht; Jerina Donald M
Facile interstrand migration of the hydrocarbon moiety of a dibenzo[a,l]pyrene 11,12-diol 13,14-epoxide adduct at N2 of deoxyguanosine in a duplex oligonucleotide.
Journal of the American Chemical Society 2006;128(31):10079-84.
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2006: Yakovleva Lyudmila; Handy Christopher J; Yagi Haruhiko; Sayer Jane M; Jerina Donald M; Shuman Stewart
Intercalating polycyclic aromatic hydrocarbon-DNA adducts poison DNA religation by Vaccinia topoisomerase and act as roadblocks to digestion by exonuclease III.
Biochemistry 2006;45(24):7644-53.
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2006: Choudhary Saba; Doherty Kevin M; Handy Christopher J; Sayer Jane M; Yagi Haruhiko; Jerina Donald M; Brosh Robert M
Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A.
The Journal of biological chemistry 2006;281(9):6000-9.
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2005: Chiapperino Dominic; Cai Mangmang; Sayer Jane M; Yagi Haruhiko; Kroth Heiko; Masutani Chikahide; Hanaoka Fumio; Jerina Donald M; Cheh Albert M
Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
The Journal of biological chemistry 2005;280(48):39684-92.
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2004: Carmella Steven G; Chen Menglan; Yagi Haruhiko; Jerina Donald M; Hecht Stephen S
Analysis of phenanthrols in human urine by gas chromatography-mass spectrometry: potential use in carcinogen metabolite phenotyping.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(12):2167-74.
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2004: Doan Lanxuan; Yagi Haruhiko; Jerina Donald M; Whalen Dale L
Synthesis and hydrolysis of a cis-chlorohydrin derived from a benzo[a]pyrene 7,8-diol 9,10-epoxide.
The Journal of organic chemistry 2004;69(23):8012-7.
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2004: Laco Gary S; Du Wu; Kohlhagen Glenda; Sayer Jane M; Jerina Donald M; Burke Thomas G; Curran Dennis P; Pommier Yves
Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies.
Bioorganic & medicinal chemistry 2004;12(19):5225-35.
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2004: Tian Ligeng; Sayer Jane M; Jerina Donald M; Shuman Stewart
Individual nucleotide bases, not base pairs, are critical for triggering site-specific DNA cleavage by vaccinia topoisomerase.
The Journal of biological chemistry 2004;279(38):39718-26.
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2004: Tuske Steve; Sarafianos Stefan G; Clark Arthur D; Ding Jianping; Naeger Lisa K; White Kirsten L; Miller Michael D; Gibbs Craig S; Boyer Paul L; Clark Patrick; Wang Gang; Gaffney Barbara L; Jones Roger A; Jerina Donald M; Hughes Stephen H; Arnold Eddy
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.
Nature structural & molecular biology 2004;11(5):469-74.
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2004: Yakovleva Lyudmila; Handy Christopher J; Sayer Jane M; Pirrung Michael; Jerina Donald M; Shuman Stewart
Benzo[c]phenanthrene adducts and nogalamycin inhibit DNA transesterification by vaccinia topoisomerase.
The Journal of biological chemistry 2004;279(22):23335-42.
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2004: Ling Hong; Sayer Jane M; Plosky Brian S; Yagi Haruhiko; Boudsocq François; Woodgate Roger; Jerina Donald M; Yang Wei
Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2265-9.
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2004: Karle Isabella L; Yagi Haruhiko; Sayer Jane M; Jerina Donald M
Crystal and molecular structure of a benzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct: absolute configuration and conformation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1433-8.
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2004: Johnson Allison A; Sayer Jane M; Yagi Haruhiko; Kalena Govind P; Amin Ronak; Jerina Donald M; Pommier Yves
Position-specific suppression and enhancement of HIV-1 integrase reactions by minor groove benzo[a]pyrene diol epoxide deoxyguanine adducts: implications for molecular interactions between integrase and substrates.
The Journal of biological chemistry 2004;279(9):7947-55.
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2004: Graziewicz Maria A; Sayer Jane M; Jerina Donald M; Copeland William C
Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine.
Nucleic acids research 2004;32(1):397-405.
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2003: Hecht Stephen S; Chen Menglan; Yagi Haruhiko; Jerina Donald M; Carmella Steven G
r-1,t-2,3,c-4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene in human urine: a potential biomarker for assessing polycyclic aromatic hydrocarbon metabolic activation.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(12):1501-8.
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2003: Khan Qasim A; Kohlhagen Glenda; Marshall Richard; Austin Caroline A; Kalena Govind P; Kroth Heiko; Sayer Jane M; Jerina Donald M; Pommier Yves
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12498-503.
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2003: Yakovleva Lyudmila; Tian Ligeng; Sayer Jane M; Kalena Govind P; Kroth Heiko; Jerina Donald M; Shuman Stewart
Site-specific DNA transesterification by vaccinia topoisomerase: effects of benzo[alpha]pyrene-dA, 8-oxoguanine, 8-oxoadenine and 2-aminopurine modifications.
The Journal of biological chemistry 2003;278(43):42170-7.
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2003: Driscoll Henry C; Matson Steven W; Sayer Jane M; Kroth Heiko; Jerina Donald M; Brosh Robert M
Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent.
The Journal of biological chemistry 2003;278(42):41126-35.
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2003: Sarafianos Stefan G; Clark Arthur D; Tuske Steve; Squire Christopher J; Das Kalyan; Sheng Dequan; Ilankumaran Palanichamy; Ramesha Andagar R; Kroth Heiko; Sayer Jane M; Jerina Donald M; Boyer Paul L; Hughes Stephen H; Arnold Eddy
Trapping HIV-1 reverse transcriptase before and after translocation on DNA.
The Journal of biological chemistry 2003;278(18):16280-8.
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2003: Kramata Pavel; Zajc Barbara; Sayer Jane M; Jerina Donald M; Wei Caroline S-J
A single site-specific trans-opened 7,8,9,10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct induces mutations at multiple sites in DNA.
The Journal of biological chemistry 2003;278(17):14940-8.
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2003: Tian Ligeng; Sayer Jane M; Kroth Heiko; Kalena Govind; Jerina Donald M; Shuman Stewart
Benzo[a]pyrene-dG adduct interference illuminates the interface of vaccinia topoisomerase with the DNA minor groove.
The Journal of biological chemistry 2003;278(11):9905-11.
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2003: Volk David E; Thiviyanathan Varatharasa; Rice Jeffrey S; Luxon Bruce A; Shah Jamshed H; Yagi Haruhiko; Sayer Jane M; Yeh Herman J C; Jerina Donald M; Gorenstein David G
Solution structure of a cis-opened (10R)-N6-deoxyadenosine adduct of (9S,10R)-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a DNA duplex.
Biochemistry 2003;42(6):1410-20.
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2002: Ramos Leilani A; Pontén Ingrid; Dipple Anthony; Kumar Subodh; Yagi Haruhiko; Sayer Jane M; Kroth Heiko; Kalena Govind; Jerina Donald M
Site-specific mutagenesis in Escherichia coli by N2-deoxyguanosine adducts derived from the highly carcinogenic fjord-region benzo[c]phenanthrene 3,4-diol 1,2-epoxides.
Chemical research in toxicology 2002;15(12):1619-26.
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2002: Frank Ekaterina G; Sayer Jane M; Kroth Heiko; Ohashi Eiji; Ohmori Haruo; Jerina Donald M; Woodgate Roger
Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota.
Nucleic acids research 2002;30(23):5284-92.
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2002: Sarafianos Stefan G; Clark Arthur D; Das Kalyan; Tuske Steve; Birktoft Jens J; Ilankumaran Palanichamy; Ramesha Andagar R; Sayer Jane M; Jerina Donald M; Boyer Paul L; Hughes Stephen H; Arnold Eddy
Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.
The EMBO journal 2002;21(23):6614-24.
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2002: Doan Lanxuan; Yagi Haruhiko; Jerina Donald M; Whalen Dale L
Chloride ion catalyzed conformational inversion of carbocation intermediates in the hydrolysis of a benzo[a]pyrene 7,8-diol 9,10-epoxide.
Journal of the American Chemical Society 2002;124(48):14382-7.
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2002: Simhadri Srilatha; Kramata Pavel; Zajc Barbara; Sayer Jane M; Jerina Donald M; Hinkle David C; Wei Caroline S-J
Benzo[a]pyrene diol epoxide-deoxyguanosine adducts are accurately bypassed by yeast DNA polymerase zeta in vitro.
Mutation research 2002;508(1-2):137-45.
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2002: Yagi Haruhiko; Ramesha Andagar R; Kalena Govind; Sayer Jane M; Kumar Subodh; Jerina Donald M
Novel stereoselective control over cis vs trans opening of benzo[c]phenanthrene 3,4-diol 1,2-epoxides by the exocyclic N(2)-amino group of deoxyguanosine in the presence of hexafluoropropan-2-ol.
The Journal of organic chemistry 2002;67(19):6678-89.
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2002: Pommier Yves; Kohlhagen Glenda; Laco Gary S; Kroth Heiko; Sayer Jane M; Jerina Donald M
Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site.
The Journal of biological chemistry 2002;277(16):13666-72.
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2002: Chiapperino Dominic; Kroth Heiko; Kramarczuk Irene H; Sayer Jane M; Masutani Chikahide; Hanaoka Fumio; Jerina Donald M; Cheh Albert M
Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts.
The Journal of biological chemistry 2002;277(14):11765-71.
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2002: Laco Gary S; Collins Jack R; Luke Brian T; Kroth Heiko; Sayer Jane M; Jerina Donald M; Pommier Yves
Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model.
Biochemistry 2002;41(5):1428-35.
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2002: Shen Xuan; Sayer Jane M; Kroth Heiko; Ponten Ingrid; O'Donnell Mike; Woodgate Roger; Jerina Donald M; Goodman Myron F
Efficiency and accuracy of SOS-induced DNA polymerases replicating benzo[a]pyrene-7,8-diol 9,10-epoxide A and G adducts.
The Journal of biological chemistry 2002;277(7):5265-74.
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2001: Peletskaya E N; Boyer P L; Kogon A A; Clark P; Kroth H; Sayer J M; Jerina D M; Hughes S H
Cross-linking of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase to template-primer.
Journal of virology 2001;75(19):9435-45.
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2001: Ilankumaran P; Pannell L K; Gebreselassie P; Pilcher A S; Yagi H; Sayer J M; Jerina D M
Patterns of resistance to exonuclease digestion of oligonucleotides containing polycyclic aromatic hydrocarbon diol epoxide adducts at N6 of deoxyadenosine.
Chemical research in toxicology 2001;14(9):1330-8.
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2001: Ramos L A; Sayer J M; Yagi H; Shah J H; Dipple A; Jerina D M
Effect of benzo-ring hydroxyl groups on site-specific mutagenesis by tetrahydrobenzo[a]pyrene adducts at N(6) of deoxyadenosine.
Chemical research in toxicology 2001;14(8):1082-9.
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2001: Doan L; Lin B; Yagi H; Jerina D M; Whalen D L
New insights on the mechanisms of the pH-independent reactions of benzo[a]pyrenes 7,8-diol 9,10-epoxides.
Journal of the American Chemical Society 2001;123(28):6785-91.
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2001: Pontén I; Kroth H; Sayer J M; Dipple A; Jerina D M
Differences between the mutational consequences of replication of cis- and trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-deoxyguanosine adducts in M13mp7L2 constructs.
Chemical research in toxicology 2001;14(6):720-6.
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2001: Kroth H; Yagi H; Sayer J M; Kumar S; Jerina D M
O(6)-allyl protected deoxyguanosine adducts of polycyclic aromatic hydrocarbons as building blocks for the synthesis of oligonucleotides.
Chemical research in toxicology 2001;14(6):708-19.
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2001: Kumar S; Chang R L; Wood A W; Xie J G; Huang M T; Cui X X; Kole P L; Sikka H C; Balani S K; Conney A H; Jerina D M
Tumorigenicity of racemic and optically pure bay region diol epoxides and other derivatives of the nitrogen heterocycle dibenz[a,h]acridine on mouse skin.
Carcinogenesis 2001;22(6):951-5.
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2001: Pradhan P; Tirumala S; Liu X; Sayer J M; Jerina D M; Yeh H J
Solution structure of a trans-opened (10S)-dA adduct of (+)-(7S,8R,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully complementary DNA duplex: evidence for a major syn conformation.
Biochemistry 2001;40(20):5870-81.
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2001: Ramesha A R; Kroth H; Jerina D M
Solvent-free synthesis of benzo[a]pyrene 7,8-diol 9,10-epoxide adducts at the N(2)-position of deoxyguanosine.
Organic letters 2001;3(4):531-3.
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2001: Pontén I; Waters L S; Sayer J M; Pilcher A S; Dipple A; Jerina D M
Influence of adduct position and sequence length on the ligation of oligonucleotides containing benzo[c]phenanthrene diol epoxide-deoxyadenosine adducts into M13mp7L2.
Mutagenesis 2001;16(1):65-9.
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2001: Conney A H; Chang R L; Cui X X; Schiltz M; Yagi H; Jerina D M; Wei S J
Dose-dependent differences in the profile of mutations induced by carcinogenic (R,S,S,R) bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons.
Advances in experimental medicine and biology 2001;500():697-707.
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2000: Volk D E; Rice J S; Luxon B A; Yeh H J; Liang C; Xie G; Sayer J M; Jerina D M; Gorenstein D G
NMR evidence for syn-anti interconversion of a trans opened (10R)-dA adduct of benzo[a]pyrene (7S,8R)-diol (9R,10S)-epoxide in a DNA duplex.
Biochemistry 2000;39(46):14040-53.
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2000: Chang R L; Wood A W; Kumar S; Lehr R E; Shirai N; Jerina D M; Conney A H
Tumorigenicity of four optically active bay-region 3,4-diol 1, 2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine on mouse skin and in newborn mice.
Carcinogenesis 2000;21(11):1997-2003.
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2000: Pommier Y; Laco G S; Kohlhagen G; Sayer J M; Kroth H; Jerina D M
Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenine.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10739-44.
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2000: Vepachedu S R; Ya N; Yagi H; Sayer J M; Jerina D M
Marked differences in base selectivity between DNA and the free nucleotides upon adduct formation from Bay- and Fjord-region diol epoxides.
Chemical research in toxicology 2000;13(9):883-90.
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2000: Kroth H; Yagi H; Seidel A; Jerina D M
New and highly efficient synthesis of cis- and trans-opened Benzo[a]pyrene 7,8-diol 9,10-epoxide adducts at the exocyclic N(2)-amino group of deoxyguanosine.
The Journal of organic chemistry 2000;65(18):5558-64.
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2000: Rao T V; Haber M T; Sayer J M; Jerina D M
Incorporation of 4-thiothymidine into DNA by the Klenow fragment and HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2000;10(9):907-10.
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2000: Pontén I; Sayer J M; Pilcher A S; Yagi H; Kumar S; Jerina D M; Dipple A
Factors determining mutagenic potential for individual cis and trans opened benzo[c]phenanthrene diol epoxide-deoxyadenosine adducts.
Biochemistry 2000;39(14):4136-44.
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2000: Pommier Y; Kohlhagen G; Pourquier P; Sayer J M; Kroth H; Jerina D M
Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2040-5.
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1999: Schiltz M; Cui X X; Lu Y P; Yagi H; Jerina D M; Zdzienicka M Z; Chang R L; Conney A H; Wei S J
Characterization of the mutational profile of (+)-7R,8S-dihydroxy-9S, 10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene at the hypoxanthine (guanine) phosphoribosyltransferase gene in repair-deficient Chinese hamster V-H1 cells.
Carcinogenesis 1999;20(12):2279-86.
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1999: Adams J D; Sayer J M; Chadha A; Shirai N; Lehr R E; Kumar S; Jerina D M
The proximate carcinogen trans-3,4-dihydroxy-3,4-dihydro-dibenz[c,h]acridine is oxidized stereoselectively and regioselectively by cytochrome 1A1, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats.
Chemico-biological interactions 1999;122(2):117-35.
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1999: Wei S J; Chang R L; Merkler K A; Gwynne M; Cui X X; Murthy B; Huang M T; Xie J G; Lu Y P; Lou Y R; Jerina D M; Conney A H
Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene.
Carcinogenesis 1999;20(9):1689-96.
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1999: Page J E; Pilcher A S; Yagi H; Sayer J M; Jerina D M; Dipple A
Mutational consequences of replication of M13mp7L2 constructs containing cis-opened benzo[a]pyrene 7,8-diol 9, 10-epoxide-deoxyadenosine adducts.
Chemical research in toxicology 1999;12(3):258-63.
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1999: Wei S J; Chang R L; Wong C Q; Cui X X; Dandamudi N; Lu Y P; Merkler K A; Sayer J M; Conney A H; Jerina D M
The ratio of deoxyadenosine to deoxyguanosine adducts formed by (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in purified calf thymus DNA and DNA in V-79 cells is independent of dose.
International journal of oncology 1999;14(3):509-13.
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1999: Pontén I; Sayer J M; Pilcher A S; Yagi H; Kumar S; Jerina D M; Dipple A
Sequence context effects on mutational properties of cis-opened benzo[c]phenanthrene diol epoxide-deoxyadenosine adducts in site-specific mutation studies.
Biochemistry 1999;38(3):1144-52.
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1999: Custer L; Zajc B; Sayer J M; Cullinane C; Phillips D R; Cheh A M; Jerina D M; Bohr V A; Mazur S J
Stereospecific differences in repair by human cell extracts of synthesized oligonucleotides containing trans-opened 7,8,9, 10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-dG adduct stereoisomers located within the human K-ras codon 12 sequence.
Biochemistry 1999;38(2):569-81.
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1998: Lipinski L J; Ross H L; Zajc B; Sayer J M; Jerina D M; Dipple A
Effect of single benzo[a]pyrene diol epoxide-deoxyguanosine adducts on the action of DNA polymerases in vitro.
International journal of oncology 1998;13(2):269-73.
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1998: Page J E; Zajc B; Oh-hara T; Lakshman M K; Sayer J M; Jerina D M; Dipple A
Sequence context profoundly influences the mutagenic potency of trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-purine nucleoside adducts in site-specific mutation studies.
Biochemistry 1998;37(25):9127-37.
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1998: Lin B; Doan L; Yagi H; Jerina D M; Whalen D L
Halide effects in the hydrolysis reactions of (+/-)-7beta, 8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo- [a]pyrene.
Chemical research in toxicology 1998;11(6):630-8.
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1997: Schwartz J L; Rice J S; Luxon B A; Sayer J M; Xie G; Yeh H J; Liu X; Jerina D M; Gorenstein D G
Solution structure of the minor conformer of a DNA duplex containing a dG mismatch opposite a benzo[a]pyrene diol epoxide/dA adduct: glycosidic rotation from syn to anti at the modified deoxyadenosine.
Biochemistry 1997;36(37):11069-76.
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1996: Agarwal R; Yagi H; Jerina D M; Dipple A
Benzo[c]phenanthrene 3,4-dihydrodiol 1,2-epoxide adducts in native and denatured DNA.
Carcinogenesis 1996;17(8):1773-6.
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1996: Wei S J; Chang R L; Cui X X; Merkler K A; Wong C Q; Yagi H; Jerina D M; Conney A H
Dose-dependent differences in the mutational profiles of (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene and its less carcinogenic enantiomer.
Cancer research 1996;56(16):3695-703.
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1996: Agarwal R; Canella K A; Yagi H; Jerina D M; Dipple A
Benzo[c]phenanthrene-DNA adducts in mouse epidermis in relation to the tumorigenicities of four configurationally isomeric 3,4-dihydrodiol 1,2-epoxides.
Chemical research in toxicology 1996;9(3):586-92.
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1996: Wondrak E M; Nashed N T; Haber M T; Jerina D M; Louis J M
A transient precursor of the HIV-1 protease. Isolation, characterization, and kinetics of maturation.
The Journal of biological chemistry 1996;271(8):4477-81.
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1995: Yeh H J; Sayer J M; Liu X; Altieri A S; Byrd R A; Lakshman M K; Yagi H; Schurter E J; Gorenstein D G; Jerina D M
NMR solution structure of a nonanucleotide duplex with a dG mismatch opposite a 10S adduct derived from trans addition of a deoxyadenosine N6-amino group to (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene: an unusual syn glycosidic torsion angle at the modified dA.
Biochemistry 1995;34(41):13570-81.
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1995: Schurter E J; Sayer J M; Oh-hara T; Yeh H J; Yagi H; Luxon B A; Jerina D M; Gorenstein D G
Nuclear magnetic resonance solution structure of an undecanucleotide duplex with a complementary thymidine base opposite a 10R adduct derived from trans addition of a deoxyadenosine N6-amino group to (-)-(7R,8S,9R,10S)-7,8-dihydroxy- 9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
Biochemistry 1995;34(28):9009-20.
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1995: LeBreton P R; Huang C R; Fernando H; Zajc B; Lakshman M K; Sayer J M; Jerina D M
Multiple fluorescence lifetimes for oligonucleotides containing single, site-specific modifications at guanine and adenine corresponding to trans addition of exocyclic amino groups to (+)-(7R,8S,9S,10R)- and (+)-(7S,8R,9R,10S) -7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
Chemical research in toxicology 1995;8(3):338-48.
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1995: Adams J D; Yagi H; Levin W; Jerina D M
Stereo-selectivity and regio-selectivity in the metabolism of 7,8-dihydrobenzo[a]pyrene by cytochrome P450, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats.
Chemico-biological interactions 1995;95(1-2):57-77.
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1995: Schurter E J; Yeh H J; Sayer J M; Lakshman M K; Yagi H; Jerina D M; Gorenstein D G
NMR solution structure of a nonanucleotide duplex with a dG mismatch opposite a 10R adduct derived from trans addition of a deoxyadenosine N6-amino group to (-)-(7S,8R,9R,10S)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene.
Biochemistry 1995;34(4):1364-75.
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1994: Christner D F; Lakshman M K; Sayer J M; Jerina D M; Dipple A
Primer extension by various polymerases using oligonucleotide templates containing stereoisomeric benzo[a]pyrene-deoxyadenosine adducts.
Biochemistry 1994;33(47):14297-305.
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1994: Louis J M; Nashed N T; Parris K D; Kimmel A R; Jerina D M
Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):7970-4.
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1994: Wei S J; Chang R L; Hennig E; Cui X X; Merkler K A; Wong C Q; Yagi H; Jerina D M; Conney A H
Mutagenic selectivity at the HPRT locus in V-79 cells: comparison of mutations caused by bay-region benzo[a]pyrene 7,8-diol-9,-10-epoxide enantiomers with high and low carcinogenic activity.
Carcinogenesis 1994;15(8):1729-35.
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1994: Bigger C A; Cheh A; Latif F; Fishel R; Canella K A; Stafford G A; Yagi H; Jerina D M; Dipple A
DNA strand breaks induced by configurationally isomeric hydrocarbon diol epoxides.
Drug metabolism reviews 1994;26(1-2):287-99.
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1994: Conney A H; Chang R L; Jerina D M; Wei S J
Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite.
Drug metabolism reviews 1994;26(1-2):125-63.
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1993: Chang R L; Battista S; Wong C Q; Kumar S; Kole P L; Sikka H C; Balani S K; Jerina D M; Conney A H; Wood A W
Bacterial and mammalian cell mutagenicity of four optically active bay-region 10,11-diol-8,9-epoxides of the nitrogen heterocycle dibenz[a,h]acridine.
Carcinogenesis 1993;14(11):2233-7.
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1993: Wei S J; Chang R L; Bhachech N; Cui X X; Merkler K A; Wong C Q; Hennig E; Yagi H; Jerina D M; Conney A H
Dose-dependent differences in the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in Chinese hamster V-79 cells.
Cancer research 1993;53(14):3294-301.
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1993: Ross H; Bigger C A; Yagi H; Jerina D M; Dipple A
Sequence specificity in the interaction of the four stereoisomeric benzo[c]phenanthrene dihydrodiol epoxides with the supF gene.
Cancer research 1993;53(6):1273-7.
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1992: Canella K A; Peltonen K; Yagi H; Jerina D M; Dipple A
Identification of individual benzo[c]phenanthrene dihydrodiol epoxide-DNA adducts by the 32P-postlabeling assay.
Chemical research in toxicology 1992;5(5):685-90.
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1992: Bigger C A; St John J; Yagi H; Jerina D M; Dipple A
Mutagenic specificities of four stereoisomeric benzo[c]phenanthrene dihydrodiol epoxides.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):368-72.
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1991: Wei S J; Chang R L; Wong C Q; Bhachech N; Cui X X; Hennig E; Yagi H; Sayer J M; Jerina D M; Preston B D
Dose-dependent differences in the profile of mutations induced by an ultimate carcinogen from benzo[a]pyrene.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11227-30.
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1991: Baillon J G; Nashed N T; Kumar A; Wilson S H; Jerina D M
A leucine zipper-like motif may mediate HIV reverse transcriptase subunit binding.
The New biologist 1991;3(10):1015-9.
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1991: Louis J M; McDonald R A; Nashed N T; Wondrak E M; Jerina D M; Oroszlan S; Mora P T
Autoprocessing of the HIV-1 protease using purified wild-type and mutated fusion proteins expressed at high levels in Escherichia coli.
European journal of biochemistry / FEBS 1991;199(2):361-9.
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1991: Thakker D R; Boehlert C; Levin W; Ryan D E; Thomas P E; Yagi H; Jerina D M
Novel stereoselectivity of rat liver cytochrome(s) P450 toward enantiomers of the trans-1,2-dihydrodiol of triphenylene.
Archives of biochemistry and biophysics 1991;288(1):54-63.
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1991: Baillon J G; Nashed N T; Sayer J M; Jerina D M
Continuous microspectrophotometric measurement of DNA polymerase activity: application to the Klenow fragment of Escherichia coli DNA polymerase I and human immunodeficiency virus type 1 reverse transcriptase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):1014-8.
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1991: Jerina D M; Chadha A; Cheh A M; Schurdak M E; Wood A W; Sayer J M
Covalent bonding of bay-region diol epoxides to nucleic acids.
Advances in experimental medicine and biology 1991;283():533-53.
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1990: Cheh A M; Yagi H; Jerina D M
Stereoselective release of polycyclic aromatic hydrocarbon-deoxyadenosine adducts from DNA by the 32P postlabeling and deoxyribonuclease I/snake venom phosphodiesterase digestion methods.
Chemical research in toxicology 1990;3(6):545-50.
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1989: Wood A W; Chang R L; Katz M; Conney A H; Jerina D M; Sikka H C; Levin W; Kumar S
Mutagenicity of dihydrodiols and diol epoxides of dibenz[a, h]acridine in bacterial and mammalian cells.
Cancer research 1989;49(24 Pt 1):6981-4.
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1989: Nashed N T; Louis J M; Sayer J M; Wondrak E M; Mora P T; Oroszlan S; Jerina D M
Continuous spectrophotometric assay for retroviral proteases of HIV-1 and AMV.
Biochemical and biophysical research communications 1989;163(2):1079-85.
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1989: Bigger C A; Strandberg J; Yagi H; Jerina D M; Dipple A
Mutagenic specificity of a potent carcinogen, benzo[c]phenanthrene (4R,3S)-dihydrodiol (2S,1R)-epoxide, which reacts with adenine and guanine in DNA.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2291-5.
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1989: Reardon D B; Bigger C A; Strandberg J; Yagi H; Jerina D M; Dipple A
Sequence selectivity in the reaction of optically active hydrocarbon dihydrodiol epoxides with rat H-ras DNA.
Chemical research in toxicology 1989;2(1):12-4.
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1989: Sayer J M; Whalen D L; Jerina D M
Chemical strategies for the inactivation of bay-region diol epoxides, ultimate carcinogens derived from polycyclic aromatic hydrocarbons.
Drug metabolism reviews 1989;20(2-4):155-82.
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1988: Thakker D R; Boehlert C; Mirsadeghi S; Levin W; Ryan D E; Thomas P E; Yagi H; Pannell L K; Sayer J M; Jerina D M
Differential stereoselectivity on metabolism of triphenylene by cytochromes P-450 in liver microsomes from 3-methylcholanthrene- and phenobarbital-treated rats.
The Journal of biological chemistry 1988;263(1):98-105.
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1987: Chang R L; Wood A W; Conney A H; Yagi H; Sayer J M; Thakker D R; Jerina D M; Levin W
Role of diaxial versus diequatorial hydroxyl groups in the tumorigenic activity of a benzo[a]pyrene bay-region diol epoxide.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8633-6.
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1987: van Bladeren P J; Balani S K; Sayer J M; Thakker D R; Boyd D R; Ryan D E; Thomas P E; Levin W; Jerina D M
Stereoselective formation of benzo(c)phenanthrene (+)-(3S,4R) and (+)-(5S,6R)-oxides by cytochrome P450c in a highly purified and reconstituted system.
Biochemical and biophysical research communications 1987;145(1):160-7.
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1986: Chang R L; Levin W; Wood A W; Shirai N; Ryan A J; Duke C C; Jerina D M; Holder G M; Conney A H
High tumorigenicity of the 3,4-dihydrodiol of 7-methylbenz[c]acridine on mouse skin and in newborn mice.
Cancer research 1986;46(9):4552-5.
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1986: Wood A W; Chang R L; Levin W; Kumar S; Shirai N; Jerina D M; Lehr R E; Conney A H
Bacterial and mammalian cell mutagenicity of four optically active bay-region 3,4-diol-1,2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine.
Cancer research 1986;46(6):2760-6.
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1985: Chang R L; Huang M T; Wood A W; Wong C Q; Newmark H L; Yagi H; Sayer J M; Jerina D M; Conney A H
Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse.
Carcinogenesis 1985;6(8):1127-33.
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1985: Huang M T; Chang R L; Wood A W; Newmark H L; Sayer J M; Yagi H; Jerina D M; Conney A H
Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by tannic acid, hydroxylated anthraquinones and hydroxylated cinnamic acid derivatives.
Carcinogenesis 1985;6(2):237-42.
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1984: Chang R L; Levin W; Wood A W; Kumar S; Yagi H; Jerina D M; Lehr R E; Conney A H
Tumorigenicity of dihydrodiols and diol-epoxides of benz[c]acridine in newborn mice.
Cancer research 1984;44(11):5161-4.
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1984: Thakker D R; Yagi H; Sayer J M; Kapur U; Levin W; Chang R L; Wood A W; Conney A H; Jerina D M
Effects of a 6-fluoro substituent on the metabolism of benzo(a)pyrene 7,8-dihydrodiol to bay-region diol epoxides by rat liver enzymes.
The Journal of biological chemistry 1984;259(18):11249-56.
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1984: van Bladeren P J; Vyas K P; Sayer J M; Ryan D E; Thomas P E; Levin W; Jerina D M
Stereoselectivity of cytochrome P-450c in the formation of naphthalene and anthracene 1,2-oxides.
The Journal of biological chemistry 1984;259(14):8966-73.
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1983: Huang M T; Wood A W; Newmark H L; Sayer J M; Yagi H; Jerina D M; Conney A H
Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids.
Carcinogenesis 1983;4(12):1631-7.
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1983: Levin W; Wood A W; Chang R L; Kumar S; Yagi H; Jerina D M; Lehr R E; Conney A H
Tumor-initiating activity of benz[c]acridine and twelve of its derivatives on mouse skin.
Cancer research 1983;43(10):4625-8.
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1983: Buening M K; Levin W; Wood A W; Chang R L; Agranat I; Rabinovitz M; Buhler D R; Mah H D; Hernandez O; Simpson R B; Jerina D M; Conney A H; Miller E C; Miller J A
Fluorine substitution as a probe for the role of the 6-position of benzo[a]pyrene in carcinogenesis.
Journal of the National Cancer Institute 1983;71(2):309-15.
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1983: Ittah Y; Thakker D R; Levin W; Croisy-Delcey M; Ryan D E; Thomas P E; Conney A H; Jerina D M
Metabolism of benzo[c]phenanthrene by rat liver microsomes and by a purified monooxygenase system reconstituted with different isozymes of cytochrome P-450.
Chemico-biological interactions 1983;45(1):15-28.
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1983: Vyas K P; van Bladeren P J; Thakker D R; Yagi H; Sayer J M; Levin W; Jerina D M
Regioselectivity and stereoselectivity in the metabolism of trans-1,2-dihydroxy-1,2-dihydrobenz[a]anthracene by rat liver microsomes.
Molecular pharmacology 1983;24(1):115-23.
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1983: Michaud D P; Gupta S C; Whalen D L; Sayer J M; Jerina D M
Effects of pH and salt concentration on the hydrolysis of a benzo[alpha]pyrene 7,8-diol-9,10-epoxide catalyzed by DNA and polyadenylic acid.
Chemico-biological interactions 1983;44(1-2):41-52.
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1983: Wood A W; Chang R L; Levin W; Ryan D E; Thomas P E; Lehr R E; Kumar S; Schaefer-Ridder M; Engelhardt U; Yagi H; Jerina D M; Conney A H
Mutagenicity of diol-epoxides and tetrahydroepoxides of benz(a)acridine and benz(c)acridine in bacteria and in mammalian cells.
Cancer research 1983;43(4):1656-62.
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1982: Wood A W; Sayer J M; Newmark H L; Yagi H; Michaud D P; Jerina D M; Conney A H
Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphate.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(17):5122-6.
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1982: Wood A W; Huang M T; Chang R L; Newmark H L; Lehr R E; Yagi H; Sayer J M; Jerina D M; Conney A H
Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(18):5513-7.
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1982: Vyas K P; Levin W; Yagi H; Thakker D R; Ryan D E; Thomas P E; Conney A H; Jerina D M
Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes.
Molecular pharmacology 1982;22(1):182-9.
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1982: van Bladeren P J; Armstrong R N; Cobb D; Thakker D R; Ryan D E; Thomas P E; Sharma N D; Boyd D R; Levin W; Jerina D M
Stereoselective formation of benz[a]anthracene (+)-(5S,6R)-oxide and (+)-(8R,9S)-oxide by a highly purified and reconstituted system containing cytochrome P-450c.
Biochemical and biophysical research communications 1982;106(2):602-9.
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1982: Vyas K P; Thakker D R; Levin W; Yagi H; Conney A H; Jerina D M
Stereoselective metabolism of the optical isomers of trans-1,2-dihydroxy-1,2-dihydrophenanthrene to bay-region diol epoxides by rat liver microsomes.
Chemico-biological interactions 1982;38(2):203-13.
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1982: Chang R L; Levin W; Wood A W; Lehr R E; Kumar S; Yagi H; Jerina D M; Conney A H
Tumorigenicity of bay-region diol-epoxides and other benzo-ring derivatives of dibenzo(a,h)pyrene and dibenzo(a,i)pyrene on mouse skin and in newborn mice.
Cancer research 1982;42(1):25-9.
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1981: Wood A W; Chang R L; Levin W; Ryan D E; Thomas P E; Lehr R E; Kumar S; Sardella D J; Boger E; Yagi H; Sayer J M; Jerina D M; Conney A H
Mutagenicity of the bay-region diol-epoxides and other benzo-ring derivatives of dibenzo(a,h)pyrene and dibenzo(a,i)pyrene.
Cancer research 1981;41(7):2589-97.
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1981: Armstrong R N; Kedzierski B; Levin W; Jerina D M
Enantioselectivity of microsomal epoxide hydrolase toward arene oxide substrates.
The Journal of biological chemistry 1981;256(10):4726-33.
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1981: Thakker D R; Levin W; Buening M; Yagi H; Lehr R E; Wood A W; Conney A H; Jerina D M
Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo[e]pyrene 9,10-dihydrodiol to bay-region diol epoxides.
Cancer research 1981;41(4):1389-96.
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1981: Chang R L; Levin W; Wood A W; Lehr R E; Kumar S; Yagi H; Jerina D M; Conney A H
Tumorigenicity of the diastereomeric bay-region benzo(e)pyrene 9,10-diol-11,12-epoxides in newborn mice.
Cancer research 1981;41(3):915-8.
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1981: Nordqvist M; Thakker D R; Vyas K P; Yagi H; Levin W; Ryan D E; Thomas P E; Conney A H; Jerina D M
Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.
Molecular pharmacology 1981;19(1):168-78.
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1981: Jerina D M; Sayer J M; Yagi H; Croisy-Delcey M; Ittah Y; Thakker D R; Wood A W; Chang R L; Levin W; Conney A H
Highly tumorigenic bay-region diol epoxides from the weak carcinogen benzo[c]phenanthrene.
Advances in experimental medicine and biology 1981;136 Pt A():501-23.
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1980: Levin W; Wood A W; Chang R L; Ittah Y; Croisy-Delcey M; Yagi H; Jerina D M; Conney A H
Exceptionally high tumor-initiating activity of benzo(c)phenanthrene bay-region diol-epoxides on mouse skin.
Cancer research 1980;40(11):3910-4.
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1980: Levin W; Buening M K; Wood A W; Chang R L; Kedzierski B; Thakker D R; Boyd D R; Gadaginamath G S; Armstrong R N; Yagi H; Karle J M; Slaga T J; Jerina D M; Conney A H
An enantiomeric interaction in the metabolism and tumorigenicity of (+)- and (-)-benzo[a]pyrene 7,8-oxide.
The Journal of biological chemistry 1980;255(19):9067-74.
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1980: Wood A W; Chang R L; Levin W; Ryan D E; Thomas P E; Croisy-Delcey M; Ittah Y; Yagi H; Jerina D M; Conney A H
Mutagenicity of the dihydrodiols and bay-region diol-epoxides of benzo(c)phenanthrene in bacterial and mammalian cells.
Cancer research 1980;40(8 Pt 1):2876-83.
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1980: Wood A W; Chang R L; Huang M T; Levin W; Lehr R E; Kumar S; Thakker D R; Yagi H; Jerina D M; Conney A H
Mutagenicity of benzo(e)pyrene and triphenylene tetrahydroepoxides and diol-epoxides in bacterial and mammalian cells.
Cancer research 1980;40(6):1985-9.
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1980: Wood A W; Levin W; Chang R L; Huang M T; Ryan D E; Thomas P E; Lehr R E; Kumar S; Koreeda M; Akagi H; Ittah Y; Dansette P; Yagi H; Jerina D M; Conney A H
Mutagenicity and tumor-initiating activity of cyclopenta(c,d)pyrene and structurally related compounds.
Cancer research 1980;40(3):642-9.
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1980: Buening M K; Levin W; Wood A W; Chang R L; Lehr R E; Taylor C W; Yagi H; Jerina D M; Conney A H
Tumorigenic activity of benzo(e)pyrene derivatives on mouse skin and in newborn mice.
Cancer research 1980;40(2):203-6.
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