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Bengt Jernström

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Anne Lagerqvist; Cecilia Lundin; Gabriela Prochazka; Dan Segerbäck; Albrecht Seidel; Margareta Törnqvist; Kristian Dreij; Klaus Erixon; Heinz Frank; Daniel Håkansson; Bengt Jernström; Dag Jenssen
DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells.
Kristian Dreij; Bengt Jernström; Ralf Morgenstern; Qasim Ali Chaudhry; Michael Hanke
A method for efficient calculation of diffusion and reactions of lipophilic compounds in complex cell geometry.
Anne Lagerqvist; Daniel Håkansson; Gabriela Prochazka; Cecilia Lundin; Kristian Dreij; Dan Segerbäck; Bengt Jernström; Margareta Törnqvist; Albrecht Seidel; Klaus Erixon; Dag Jenssen
Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.

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All Publications

2011: Anne Lagerqvist; Cecilia Lundin; Gabriela Prochazka; Dan Segerbäck; Albrecht Seidel; Margareta Törnqvist; Kristian Dreij; Klaus Erixon; Heinz Frank; Daniel Håkansson; Bengt Jernström; Dag Jenssen
DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells.
DNA repair 2011;10(8):877-86.
2011: Kristian Dreij; Bengt Jernström; Ralf Morgenstern; Qasim Ali Chaudhry; Michael Hanke
A method for efficient calculation of diffusion and reactions of lipophilic compounds in complex cell geometry.
PloS one 2011;6(8):e23128.
2008: Anne Lagerqvist; Daniel Håkansson; Gabriela Prochazka; Cecilia Lundin; Kristian Dreij; Dan Segerbäck; Bengt Jernström; Margareta Törnqvist; Albrecht Seidel; Klaus Erixon; Dag Jenssen
Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.
DNA repair 2008;7(8):1202-12.
2008: Gerd Pääjärvi; Bengt Jernström; Albrecht Seidel; Ulla Stenius
Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation.
Molecular carcinogenesis 2008;47(4):301-9.
2005: Kristian Dreij; Albrecht Seidel; Bengt Jernström
Differential removal of DNA adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells.
Chemical research in toxicology 2005;18(4):655-64.
2003: Kyung-Bin Cho; Kristian Dreij; Bengt Jernström; Astrid Gräslund
Conformations of benzene- and dibenzo[a,l]pyrene diol epoxides studied by density functional theory: ground states, transition states, dynamics, and solvent effects.
Chemical research in toxicology 2003;16(5):590-7.
2002: Kristian Dreij; Kathrin Sundberg; Ann-Sofie Johansson; erik Nordling; Albrecht Seidel; Bengt Persson; Bengt Mannervik; Bengt Jernström
Catalytic activities of human alpha class glutathione transferases toward carcinogenic dibenzo[a,l]pyrene diol epoxides.
Chemical research in toxicology 2002;15(6):825-31.
2002: Kathrin Sundberg; Kristian Dreij; Albrecht Seidel; Bengt Jernström
Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases.
Chemical research in toxicology 2002;15(2):170-9.
2000: Kathrin Sundberg; Bengt Jernström; S Swedmark
Studies on the differential inhibition of glutathione conjugate formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and 1-chloro-2,4-dinitrobenzene in V79 Chinese hamster cells.
The Biochemical journal 2000;349 Pt 3():693-6.
1999: P Pradhan; Astrid Gräslund; Albrecht Seidel; Bengt Jernström
Implications of cytosine methylation on (+)-anti-Benzo[a]pyrene 7, 8-dihydrodiol 9,10-epoxide N(2)-dG adduct formation in 5'-d(CGT), 5'-d(CGA), and 5'-d(CGC) sequence contexts of single- and double-stranded oligonucleotides.
Chemical research in toxicology 1999;12(9):816-21.
1999: P Pradhan; Bengt Jernström; Albrecht Seidel; Bengt Nordén; Astrid Gräslund
Studies on the adduct heterogeneity of benzo[a]pyrene 7, 8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy.
Chemical research in toxicology 1999;12(5):403-11.
1998: Kathrin Sundberg; Albrecht Seidel; Bengt Mannervik; Bengt Jernström
Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione.
FEBS letters 1998;438(3):206-10.
1998: Wanda R Fields; Charles S Morrow; AJ Doss; Kathrin Sundberg; Bengt Jernström; Alan J Townsend
Overexpression of stably transfected human glutathione S-transferase P1-1 protects against DNA damage by benzo[a]pyrene diol-epoxide in human T47D cells.
Molecular pharmacology 1998;54(2):298-304.
1998: P Pradhan; Bengt Jernström; Albrecht Seidel; Bengt Nordén; Astrid Gräslund
Induced circular dichroism of benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides used to probe equilibrium distribution between groove binding and intercalative adduct conformations.
Biochemistry 1998;37(13):4664-73.
1998: Kathrin Sundberg; Ann-Sofie Johansson; Gun Stenberg; Mikael Widersten; Albrecht Seidel; Bengt Mannervik; Bengt Jernström
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
Carcinogenesis 1998;19(3):433-6.
1997: Kathrin Sundberg; Mikael Widersten; Albrecht Seidel; Bengt Mannervik; Bengt Jernström
Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1.
Chemical research in toxicology 1997;10(11):1221-7.
1997: M Funk; I Pontén; Albrecht Seidel; Bengt Jernström
Critical parameters for adduct formation of the carcinogen (+)-anti-benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide with oligonucleotides.
Bioconjugate chemistry 1997;8(3):310-7.
1996: A E Persson; I Pontén; I Cotgreave; Bengt Jernström
Inhibitory effects on the DNA binding of AP-1 transcription factor to an AP-1 binding site modified by benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide diastereomers.
Carcinogenesis 1996;17(9):1963-9.
1996: S Swedmark; Bengt Jernström; Dag Jenssen
Comparison of the mRNA sequences for Pi class glutathione transferases in different hamster species and the corresponding enzyme activities with anti-benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide.
The Biochemical journal 1996;318 ( Pt 2)():533-8.
1996: I Pontén; Albrecht Seidel; A Gräslund; Bengt Jernström
Synthesis and characterization of adducts derived from the syn-diastereomer of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and the 5'-d(CCTATAGATATCC) oligonucleotide.
Chemical research in toxicology 1996;9(1):188-96.
1995: D Constantin; K Mehrotra; Alf Wallin; P Moldéus; Bengt Jernström
Studies on the effect of sulfite on benzo[a]pyrene-7,8-dihydrodiol activation to reactive intermediates in human polymorphonuclear leukocytes.
Chemico-biological interactions 1995;94(1):73-82.
1994: I Pontén; S K Kim; A Gräslund; B Nordén; Bengt Jernström
Spectroscopic studies of the trans adducts derived from (+)- and (-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and the oligonucleotide 5'-d(CCTATAGATATCC).
Carcinogenesis 1994;15(10):2207-13.
1994: D Constantin; K Mehrotra; A Rahimtula; P Moldéus; Bengt Jernström
Stimulatory effects of sulfur and nitrogen oxides on carcinogen activation in human polymorphonuclear leukocytes.
Environmental health perspectives 1994;102 Suppl 4():161-4.
1994: D Constantin; Alf Wallin; P Moldéus; Bengt Jernström
Stimulant effect of nitrite on the activation of benzo[a]pyrene-7,8-dihydrodiol in human polymorphonuclear leucocytes.
Toxicology in vitro : an international journal published in association with BIBRA 1994;8(4):593-5.
1994: K Mehrotra; D Constantin; Alf Wallin; P Moldéus; Bengt Jernström
Nitrite-stimulated DNA-binding of carcinogenic diol epoxides from benzo[a]pyrene-7,8-dihydrodiol in human polymorphonuclear leukocytes.
Cancer letters 1994;78(1-3):49-56.
1994: Bengt Jernström; A Gräslund
Covalent binding of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxides to DNA: molecular structures, induced mutations and biological consequences.
Biophysical chemistry 1994;49(3):185-99.
1994: D Constantin; K Mehrotra; Bengt Jernström; Aldo Tomasi; P Moldéus
Alternative pathways of sulfite oxidation in human polymorphonuclear leukocytes.
Pharmacology & toxicology 1994;74(2):136-40.
1994: I Pontén; S K Kim; A Gräslund; B Nordén; Bengt Jernström
Synthesis and characterization of a (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide-oligonucleotide adduct.
IARC scientific publications 1994;(125):433-6.
1993: Bengt Jernström; R Morgenstern; P Moldéus
Protective role of glutathione, thiols, and analogues in mutagenesis and carcinogenesis.
Basic life sciences 1993;61():137-47.
1992: Bengt Jernström; A Seidel; M Funk; F Oesch; B Mannervik
Glutathione conjugation of trans-3,4-dihydroxy 1,2-epoxy 1,2,3,4-tetrahydrobenzo[c]phenanthrene isomers by human glutathione transferases.
Carcinogenesis 1992;13(9):1549-55.
1991: D Constantin; Bengt Jernström; Ian A Cotgreave; P Moldeus
Sodium nitrite-stimulated metabolic activation of benzo[a]pyrene 7,8-dihydrodiol in human polymorphonuclear leukocytes.
Carcinogenesis 1991;12(5):777-81.
1989: L Romert; L Dock; Dag Jenssen; Bengt Jernström
Effects of glutathione transferase activity on benzo[a]pyrene 7,8-dihydrodiol metabolism and mutagenesis studied in a mammalian cell co-cultivation assay.
Carcinogenesis 1989;10(9):1701-7.
1989: L Dock; M Martinez; Bengt Jernström
The influence of cytochrome P-450 induction on the disposition of carcinogenic benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide in isolated cells.
Carcinogenesis 1989;10(2):245-9.
1989: Bengt Jernström; L Dock; M Hall; B Mannervik; M K Tahir; P L Grover
Glutathione transferase catalyzed conjugation of benzo[a]pyrene 7,8-diol 9,10-epoxide with glutathione in human skin.
Chemico-biological interactions 1989;70(1-2):173-80.
1988: O Beck; Bengt Jernström; M Martinez; D B Repke
In vitro study of the aromatic hydroxylation of 1-methyltetrahydro-beta-carboline (methtryptoline) in rat.
Chemico-biological interactions 1988;65(1):97-106.
1988: L Dock; G Scheu; Bengt Jernström; M Martinez; U B Torndal; L Eriksson
Benzo[a]pyrene metabolism and induction of enzyme-altered foci in regenerating rat liver.
Chemico-biological interactions 1988;67(3-4):243-53.
1987: I Zegar; P O Lycksell; A Gräslund; M Eriksson; B Nordén; Bengt Jernström
Spectroscopic studies on double-stranded poly d[(G-C)(G-C)] in B and Z form after covalent modification with the anti diastereomer of trans-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
Carcinogenesis 1987;8(7):899-905.
1987: L Dock; M Martinez; Bengt Jernström
Increased stability of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo [a]pyrene through interaction with subcellular fractions of rat liver.
Chemico-biological interactions 1987;61(1):31-44.
1986: I G Robertson; Bengt Jernström
The enzymatic conjugation of glutathione with bay-region diol-epoxides of benzo[a]pyrene, benz[a]anthracene and chrysene.
Carcinogenesis 1986;7(10):1633-6.
1986: I G Robertson; C Guthenberg; B Mannervik; Bengt Jernström
Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene.
Cancer research 1986;46(5):2220-4.
1986: I G Robertson; H Jensson; B Mannervik; Bengt Jernström
Glutathione transferases in rat lung: the presence of transferase 7-7, highly efficient in the conjugation of glutathione with the carcinogenic (+)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
Carcinogenesis 1986;7(2):295-9.
1985: P O Lycksell; A Gräslund; A Ehrenberg; Bengt Jernström; B Nordén
Facilitation of the conversion from B to Z conformation in poly(dG-dC) modified by anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide.
The Journal of biological chemistry 1985;260(10):5857-9.
1985: I G Robertson; H Jensson; C Guthenberg; M K Tahir; Bengt Jernström; B Mannervik
Differences in the occurrence of glutathione transferase isoenzymes in rat lung and liver.
Biochemical and biophysical research communications 1985;127(1):80-6.
1984: Bengt Jernström; P O Lycksell; A Gräslund; B Nordén
Spectroscopic studies of DNA complexes formed after reaction with anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide enantiomers of different carcinogenic potency.
Carcinogenesis 1984;5(9):1129-35.
1984: Bengt Jernström; M Martinez; S A Svensson; L Dock
Metabolism of benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide to protein-binding products and glutathione conjugates in isolated rat hepatocytes.
Carcinogenesis 1984;5(8):1079-85.
1984: L Dock; M Martinez; Bengt Jernström
Induction of hepatic glutathione S-transferase activity by butylated hydroxyanisole and conjugation of benzo[a]pyrene diol-epoxide.
Carcinogenesis 1984;5(6):841-4.
1984: Bengt Jernström; L Dock; M Martinez
Metabolic activation of benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide to protein-binding products and the inhibitory effect of glutathione and cysteine.
Carcinogenesis 1984;5(2):199-204.
1984: A Gräslund; Bengt Jernström; O Undeman; L Dock; A Ehrenberg; T Astlind
Fluorescence measurements of DNA-bound metabolites of benzo(a)pyrene derivatives with different carcinogenic effects.
Toxicologic pathology 1984;12(2):179-84.
1983: E Seeberg; A L Steinum; M Nordenskjöld; S Söderhäll; Bengt Jernström
Strand-break formation in DNA modified by benzo[alpha]pyrene diolepoxide. Quantitative cleavage by Escherichia coli uvrABC endonuclease.
Mutation research 1983;112(3):139-45.
1983: O Undeman; P O Lycksell; A Gräslund; T Astlind; A Ehrenberg; Bengt Jernström; F Tjerneld; B Nordén
Covalent complexes of DNA and two stereoisomers of benzo(a)pyrene 7,8-dihydrodiol-9,10-epoxide studied by fluorescence and linear dichroism.
Cancer research 1983;43(4):1851-60.
1982: L Dock; Y N Cha; Bengt Jernström; P Moldéus
Effect of 2(3)-tert-butyl-4-hydroxyanisole on benzo[a]pyrene metabolism and DNA-binding of benzo[a]pyrene metabolites in isolated mouse hepatocytes.
Chemico-biological interactions 1982;41(1):25-37.
1982: A D Rahimtula; Bengt Jernström; L Dock; P Moldeus
Effects of dietary and in vitro 2(3)-t-butyl-4-hydroxy-anisole and other phenols on hepatic enzyme activities in mice.
British journal of cancer 1982;45(6):935-44.
1982: P Moldéus; L Dock; Y N Cha; M Berggren; Bengt Jernström
Elevation of conjugation capacity in isolated hepatocytes from BHA-treated mice.
Biochemical pharmacology 1982;31(10):1907-10.
1982: L Dock; Y N Cha; Bengt Jernström; P Moldéus
Differential effects of dietary BHA on hepatic enzyme activities and benzo[a]pyrene metabolism in male and female NMRI mice.
Carcinogenesis 1982;3(1):15-9.
1982: B Lambert; I Berndtsson; J Lindsten; M Nordenskjöld; S Söderhäll; B Holmstedt; L Palmèr; Bengt Jernström; L Marsk
Smoking and sister chromatid exchange.
Progress in clinical and biological research 1982;109():401-14.
1982: L Dock; A Rahimtula; Bengt Jernström; P Moldéus
Metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in mouse liver microsomes and the effect of 2(3)-tert-butyl-4-hydroxy-anisole.
Carcinogenesis 1982;3(6):697-701.
1981: M Nordenskjöld; S A Svensson; Bengt Jernström; P Moldéus; L Dock; S Söderhäll
Studies on the in vitro transfer of DNA binding benzo[a]pyrene metabolites from rat hepatocytes to human fibroblasts.
Carcinogenesis 1981;2(11):1151-60.
1980: O Undeman; Margareta Sahlin; A Gräslund; A Ehrenberg; L Dock; Bengt Jernström
Fluorescence study of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene metabolism in vitro and binding to DNA.
Biochemical and biophysical research communications 1980;94(2):458-65.