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Sissy Jhiang

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Zhaoxia Zhang; Sasha Beyer; Sissy M Jhiang
MEK inhibition leads to lysosome-mediated Na+/I- symporter protein degradation in human breast cancer cells.
Ziqing Qian; Amy M Barrios; Roger Briesewitz; Sissy M Jhiang; Tao Liu; Yu-Yu Liu; Dehua Pei
Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs.
Michael P Brandt; Richard T Kloos; Yu-Yu Liu; Daniel H Shen; Xiaoli Zhang; Sissy M Jhiang
Micro-single-photon emission computed tomography image acquisition and quantification of sodium-iodide symporter-mediated radionuclide accumulation in mouse thyroid and salivary glands.

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2013: Zhaoxia Zhang; Sasha Beyer; Sissy M Jhiang
MEK inhibition leads to lysosome-mediated Na+/I- symporter protein degradation in human breast cancer cells.
Endocrine-related cancer 2013;20(2):241-50.
2013: Ziqing Qian; Amy M Barrios; Roger Briesewitz; Sissy M Jhiang; Tao Liu; Yu-Yu Liu; Dehua Pei
Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs.
ACS chemical biology 2013;8(2):423-31.
2012: Michael P Brandt; Richard T Kloos; Yu-Yu Liu; Daniel H Shen; Xiaoli Zhang; Sissy M Jhiang
Micro-single-photon emission computed tomography image acquisition and quantification of sodium-iodide symporter-mediated radionuclide accumulation in mouse thyroid and salivary glands.
Thyroid : official journal of the American Thyroid Association 2012;22(6):617-24.
2012: Yu-Yu Liu; Matthew D Ringel; Xiaoli Zhang; Sissy M Jhiang
Modulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells.
Endocrine-related cancer 2012;19(3):291-304.
2011: Yu-Yu Liu; Michael P Brandt; Daniel H Shen; Richard T Kloos; Xiaoli Zhang; Sissy M Jhiang
Single photon emission computed tomography imaging for temporal dynamics of thyroidal and salivary radionuclide accumulation in 17-allyamino-17-demothoxygeldanamycin-treated thyroid cancer mouse model.
Endocrine-related cancer 2011;18(1):27-37.
2011: Sasha J Beyer; Kun Huang; Rafael E Jimenez; Mei-Ling T Lee; Andrea L Richardson; Xiaoli Zhang; Sissy M Jhiang
Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer.
BMC research notes 2011;4():397.
2010: Sissy M Jhiang; Manisha H Shah
Prospects for small interfering RNA therapeutics in thyroid cancer.
Thyroid : official journal of the American Thyroid Association 2010;20(10):1049-50.
2009: Yanan Huang; Jingfang Wan; Ming-Chieh Cheng; Zhipeng Zhang; Sissy M Jhiang; Chia-Hsiang Menq
Three-axis rapid steering of optically propelled micro/nanoparticles.
The Review of scientific instruments 2009;80(6):063107.
2009: S J Beyer; R E Jimenez; Charles L Shapiro; Je-Yoel Cho; Sissy M Jhiang
Do cell surface trafficking impairments account for variable cell surface sodium iodide symporter levels in breast cancer?
Breast cancer research and treatment 2009;115(1):205-12.
2008: G R Jayanth; Sissy M Jhiang; Chia-Hsiang Menq
Two-axis probing system for atomic force microscopy.
The Review of scientific instruments 2008;79(2 Pt 1):023705.
2007: Douangsone D Vadysirisack; Eric S-W Chen; Zhaoxia Zhang; Ming-Daw Tsai; Geen-Dong Chang; Sissy M Jhiang
Identification of in vivo phosphorylation sites and their functional significance in the sodium iodide symporter.
The Journal of biological chemistry 2007;282(51):36820-8.
2007: Katherine A B Knostman; Anjli Venkateswaran; Bevin Zimmerman; Charles C Capen; Sissy M Jhiang
Creation and characterization of a doxycycline-inducible mouse model of thyroid-targeted RET/PTC1 oncogene and luciferase reporter gene coexpression.
Thyroid : official journal of the American Thyroid Association 2007;17(12):1181-8.
2007: Douangsone D Vadysirisack; Anjli Venkateswaran; Zhaoxia Zhang; Sissy M Jhiang
MEK signaling modulates sodium iodide symporter at multiple levels and in a paradoxical manner.
Endocrine-related cancer 2007;14(2):421-32.
2007: Katherine A B Knostman; James A McCubrey; Carl D Morrison; Zhaoxia Zhang; Charles C Capen; Sissy M Jhiang
PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer.
BMC cancer 2007;7():137.
2007: Katherine A B Knostman; Sissy M Jhiang; Charles C Capen
Genetic alterations in thyroid cancer: the role of mouse models.
Veterinary pathology 2007;44(1):1-14.
2006: Douangsone D Vadysirisack; D H Y Shen; Sissy M Jhiang
Correlation of Na+/I- symporter expression and activity: implications of Na+/I- symporter as an imaging reporter gene.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(1):182-90.
2006: Marta S Sarquis; Frank Weber; Lei Shen; Christoph E Broelsch; Sissy M Jhiang; Jan Zedenius; Andrea Frilling; Charis Eng
High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas.
The Journal of clinical endocrinology and metabolism 2006;91(1):262-9.
2005: Zhaoxia Zhang; Yu-Yu Liu; Sissy M Jhiang
Cell surface targeting accounts for the difference in iodide uptake activity between human Na+/I- symporter and rat Na+/I- symporter.
The Journal of clinical endocrinology and metabolism 2005;90(11):6131-40.
2005: Kenneth E Morgenstern; Douangsone D Vadysirisack; Zhaoxia Zhang; Kenneth V Cahill; Jill A Foster; John A Burns; Richard T Kloos; Sissy M Jhiang
Expression of sodium iodide symporter in the lacrimal drainage system: implication for the mechanism underlying nasolacrimal duct obstruction in I(131)-treated patients.
Ophthalmic plastic and reconstructive surgery 2005;21(5):337-44.
2005: Derek K Marsee; Douangsone D Vadysirisack; Carl D Morrison; Manju L Prasad; Charis Eng; Quan-Yang Duh; Katherine A Rauen; Richard T Kloos; Sissy M Jhiang
Variable expression of coxsackie-adenovirus receptor in thyroid tumors: implications for adenoviral gene therapy.
Thyroid : official journal of the American Thyroid Association 2005;15(9):977-87.
2004: Anjli Venkateswaran; Derek K Marsee; Steven H Green; Sissy M Jhiang
Forskolin, 8-Br-3',5'-cyclic adenosine 5'-monophosphate, and catalytic protein kinase A expression in the nucleus increase radioiodide uptake and sodium/iodide symporter protein levels in RET/PTC1-expressing cells.
The Journal of clinical endocrinology and metabolism 2004;89(12):6168-72.
2004: Derek K Marsee; Anjli Venkateswaran; Haiyang Tao; Douangsone D Vadysirisack; Zhaoxia Zhang; Dale D Vandre; Sissy M Jhiang
Inhibition of heat shock protein 90, a novel RET/PTC1-associated protein, increases radioiodide accumulation in thyroid cells.
The Journal of biological chemistry 2004;279(42):43990-7.
2004: Katherine A B Knostman; Je-Yoel Cho; Kwon-Yul Ryu; Xiaoqin Lin; James A McCubrey; Timothy Hla; Catherine H Liu; Emma Di Carlo; Ruth Keri; Ming Zhang; Dae Y Hwang; William C Kisseberth; Charles C Capen; Sissy M Jhiang
Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer.
The Journal of clinical endocrinology and metabolism 2004;89(10):5196-203.
2004: Eri Miyagi; Milena Braga-Basaria; Elena Hardy; Vasily Vasko; Kenneth D Burman; Sissy M Jhiang; Motoyasu Saji; Matthew D Ringel
Chronic expression of RET/PTC 3 enhances basal and insulin-stimulated PI3 kinase/AKT signaling and increases IRS-2 expression in FRTL-5 thyroid cells.
Molecular carcinogenesis 2004;41(2):98-107.
2004: Micheala A Aldred; Ying Huang; Sandya Liyanarachchi; Natalia S Pellegata; Oliver Gimm; Sissy M Jhiang; Ramana V Davuluri; Albert de La Chapelle; Charis Eng
Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(17):3531-9.
2004: Xiaoqin Lin; Andrew H Fischer; Kwon-Yul Ryu; Je-Yoel Cho; Thomas J Sferra; Richard T Kloos; Ernest L Mazzaferri; Sissy M Jhiang
Application of the Cre/loxP system to enhance thyroid-targeted expression of sodium/iodide symporter.
The Journal of clinical endocrinology and metabolism 2004;89(5):2344-50.
2004: John A Burns; Kenneth E Morgenstern; Kenneth V Cahill; Jill A Foster; Sissy M Jhiang; Richard T Kloos
Nasolacrimal obstruction secondary to I(131) therapy.
Ophthalmic plastic and reconstructive surgery 2004;20(2):126-9.
2004: Derek K Marsee; D H Y Shen; Lawrence R MacDonald; Douangsone D Vadysirisack; Xiaoqin Lin; George Hinkle; Richard T Kloos; Sissy M Jhiang
Imaging of metastatic pulmonary tumors following NIS gene transfer using single photon emission computed tomography.
Cancer gene therapy 2004;11(2):121-7.
2004: Xiaoqin Lin; Kwon-Yul Ryu; Sissy M Jhiang
Cloning of the 5'-flanking region of mouse sodium/iodide symporter and identification of a thyroid-specific and TSH-responsive enhancer.
Thyroid : official journal of the American Thyroid Association 2004;14(1):19-27.
2004: D H Y Shen; Derek K Marsee; J Schaap; W Yang; Je-Yoel Cho; George Hinkle; Haikady N Nagaraja; Richard T Kloos; RF Barth; Sissy M Jhiang
Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS)-targeted radionuclide therapy.
Gene therapy 2004;11(2):161-9.
2003: Kenneth N Barton; Donald Tyson; Hans Stricker; Young S Lew; Gregory Heisey; Sweaty Koul; Alberto de la Zerda; Fang-Fang Yin; Hui Yan; Tavarekere N Nagaraja; Kelly Ann Randall; Guk Kim Jin; Joseph D Fenstermacher; Sissy M Jhiang; Jae Ho Kim; Svend O Freytag; Stephen L Brown
GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(3):508-18.
2003: Andrew H Fischer; Panya Taysavang; Sissy M Jhiang
Nuclear envelope irregularity is induced by RET/PTC during interphase.
The American journal of pathology 2003;163(3):1091-100.
2003: Micheala A Aldred; Margaret E Ginn-Pease; Carl D Morrison; Anthony P Popkie; Oliver Gimm; Cuong Hoang-Vu; Ulf Krause; Henning Dralle; Sissy M Jhiang; Christoph Plass; Charis Eng
Caveolin-1 and caveolin-2,together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis.
Cancer research 2003;63(11):2864-71.
2003: Micheala A Aldred; Carl Morrison; Oliver Gimm; Cuong Hoang-Vu; Ulf Krause; Henning Dralle; Sissy M Jhiang; Charis Eng
Peroxisome proliferator-activated receptor gamma is frequently downregulated in a diversity of sporadic nonmedullary thyroid carcinomas.
Oncogene 2003;22(22):3412-6.
2003: Krista M D La Perle; Eric A G Blomme; Charles C Capen; Sissy M Jhiang
Effect of exogenous human sodium iodide symporter expression on growth of MATLyLu cells.
Thyroid : official journal of the American Thyroid Association 2003;13(2):133-40.
2002: Richard T Kloos; Vani Duvuuri; Sissy M Jhiang; Kenneth V Cahill; Jill A Foster; John A Burns
Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2002;87(12):5817-20.
2002: Tara L F Buckwalter; Anjli Venkateswaran; Marc Lavender; Krista M D La Perle; Je-Yoel Cho; Michael L Robinson; Sissy M Jhiang
The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation.
Oncogene 2002;21(53):8166-72.
2002: Aneeta Patel; Sissy M Jhiang; Shalini Dogra; Richard Terrell; Patricia A Powers; Cydney Fenton; Catherine A Dinauer; R Michael Tuttle; Gary L Francis
Differentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescents.
Pediatric research 2002;52(5):737-44.
2002: Je-Yoel Cho; D H Y Shen; W Yang; B Williams; Tara L F Buckwalter; Krista M D La Perle; George Hinkle; Rodney V Pozderac; Richard T Kloos; Haikady N Nagaraja; RF Barth; Sissy M Jhiang
In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomas.
Gene therapy 2002;9(17):1139-45.
2002: Krista M D La Perle; Daniel Shen; Tara L F Buckwalter; Bonnie Williams; Aaron Haynam; George Hinkle; Rodney V Pozderac; Charles C Capen; Sissy M Jhiang
In vivo expression and function of the sodium iodide symporter following gene transfer in the MATLyLu rat model of metastatic prostate cancer.
The Prostate 2002;50(3):170-8.
2000: Sissy M Jhiang
The RET proto-oncogene in human cancers.
Oncogene 2000;19(49):5590-7.
2000: Je-Yoel Cho; Renée Léveillé; R Kao; B Rousset; A F Parlow; William E Burak; Ernest L Mazzaferri; Sissy M Jhiang
Hormonal regulation of radioiodide uptake activity and Na+/I- symporter expression in mammary glands.
The Journal of clinical endocrinology and metabolism 2000;85(8):2936-43.
2000: Krista M D La Perle; Sissy M Jhiang; Charles C Capen
Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas.
The American journal of pathology 2000;157(2):671-7.
2000: Je-Yoel Cho; S Xing; X Liu; Tara L F Buckwalter; L Hwa; Thomas J Sferra; Ing-Ming Chiu; Sissy M Jhiang
Expression and activity of human Na+/I- symporter in human glioma cells by adenovirus-mediated gene delivery.
Gene therapy 2000;7(9):740-9.
2000: Sissy M Jhiang
Regulation of sodium/iodide symporter.
Reviews in endocrine & metabolic disorders 2000;1(3):205-15.
1999: Je-Yoel Cho; John E Sagartz; Charles C Capen; Ernest Mazzaferri; Sissy M Jhiang
Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice.
Oncogene 1999;18(24):3659-65.
1999: Kwon-Yul Ryu; M E Senokozlieff; PA Smanik; Mariwil G Wong; Allan E Siperstein; Quan-Yang Duh; Orlo H Clark; Ernest L Mazzaferri; Sissy M Jhiang
Development of reverse transcription-competitive polymerase chain reaction method to quantitate the expression levels of human sodium iodide symporter.
Thyroid : official journal of the American Thyroid Association 1999;9(4):405-9.
1998: Sissy M Jhiang; Je-Yoel Cho; Kwon-Yul Ryu; Barry R DeYoung; PA Smanik; VR McGaughy; Andrew H Fischer; Ernest L Mazzaferri
An immunohistochemical study of Na+/I- symporter in human thyroid tissues and salivary gland tissues.
Endocrinology 1998;139(10):4416-9.
1998: Kwon-Yul Ryu; Q Tong; Sissy M Jhiang
Promoter characterization of the human Na+/I- symporter.
The Journal of clinical endocrinology and metabolism 1998;83(9):3247-51.
1998: S Xing; T L Furminger; Q Tong; Sissy M Jhiang
Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells.
The Journal of biological chemistry 1998;273(9):4909-14.
1998: Sissy M Jhiang; Je-Yoel Cho; T L Furminger; John E Sagartz; Q Tong; Charles C Capen; Ernest Mazzaferri
Thyroid carcinomas in RET/PTC transgenic mice.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;154():265-70.
1997: Q Tong; Kwon-Yul Ryu; Sissy M Jhiang
Promoter characterization of the rat Na+/I- symporter gene.
Biochemical and biophysical research communications 1997;239(1):34-41.
1997: PA Smanik; Kwon-Yul Ryu; Karl S Theil; Ernest L Mazzaferri; Sissy M Jhiang
Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter.
Endocrinology 1997;138(8):3555-8.
1997: Q Tong; S Xing; Sissy M Jhiang
Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity.
The Journal of biological chemistry 1997;272(14):9043-7.
1997: John E Sagartz; Sissy M Jhiang; Q Tong; Charles C Capen
Thyroid-stimulating hormone promotes growth of thyroid carcinomas in transgenic mice with targeted expression of the ret/PTC1 oncogene.
Laboratory investigation; a journal of technical methods and pathology 1997;76(3):307-18.
1996: P A Smanik; Q Liu; T L Furminger; K Ryu; S Xing; Ernest L Mazzaferri; Sissy M Jhiang
Cloning of the human sodium lodide symporter.
Biochemical and biophysical research communications 1996;226(2):339-45.
1996: S Xing; P A Smanik; Michael Oglesbee; James E Trosko; Ernest L Mazzaferri; Sissy M Jhiang
Characterization of ret oncogenic activation in MEN2 inherited cancer syndromes.
Endocrinology 1996;137(5):1512-9.
1996: Sissy M Jhiang; L Fithian; Christopher M Weghorst; Orlo H Clark; J M Falko; Thomas M O'Dorisio; Ernest L Mazzaferri
RET mutation screening in MEN2 patients and discovery of a novel mutation in a sporadic medullary thyroid carcinoma.
Thyroid : official journal of the American Thyroid Association 1996;6(2):115-21.
1996: G H Jossart; B O'Brien; Jan-Fang Cheng; Q Tong; Sissy M Jhiang; Quan-Yang Duh; Orlo H Clark; Heinz-Ulrich G Weier
A novel multicolor hybridization scheme applied to localization of a transcribed sequence (D10S170/H4) and deletion mapping in the thyroid cancer cell line TPC-1.
Cytogenetics and cell genetics 1996;75(4):254-7.
1996: Sissy M Jhiang; John E Sagartz; Q Tong; J Parker-Thornburg; Charles C Capen; Je-Yoel Cho; S Xing; C Ledent
Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.
Endocrinology 1996;137(1):375-8.
1995: P A Smanik; T L Furminger; Ernest L Mazzaferri; Sissy M Jhiang
Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma.
Human molecular genetics 1995;4(12):2313-8.
1995: Q Tong; Y Li; P A Smanik; L J Fithian; S Xing; Ernest L Mazzaferri; Sissy M Jhiang
Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene.
Oncogene 1995;10(9):1781-7.
1995: Ernest L Mazzaferri; Sissy M Jhiang
Differentiated thyroid cancer long-term impact of initial therapy.
Transactions of the American Clinical and Climatological Association 1995;106():151-68; discussion 168-70.
1994: S Xing; Q Tong; T Suzuki; Sissy M Jhiang
Alternative splicing of the ret proto-oncogene at intron 4.
Biochemical and biophysical research communications 1994;205(3):1526-32.
1994: Sissy M Jhiang; P A Smanik; Ernest L Mazzaferri
Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma.
Cancer letters 1994;78(1-3):69-76.
1994: Sissy M Jhiang; Ernest L Mazzaferri
The ret/PTC oncogene in papillary thyroid carcinoma.
The Journal of laboratory and clinical medicine 1994;123(3):331-7.
1994: P A Smanik; L J Fithian; Sissy M Jhiang
Thyroid peroxidase expression and DNA polymorphisms in thyroid cancer.
Biochemical and biophysical research communications 1994;198(3):948-54.
1993: Sissy M Jhiang; L Fithian; P Smanik; J McGill; Q Tong; Ernest L Mazzaferri
Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells.
FEBS letters 1993;318(2):139-44.
1992: Sissy M Jhiang; D R Caruso; E Gilmore; Y Ishizaka; T Tahira; M Nagao; Ing-Ming Chiu; Ernest L Mazzaferri
Detection of the PTC/retTPC oncogene in human thyroid cancers.
Oncogene 1992;7(7):1331-7.
1991: Sissy M Jhiang; Ing-Ming Chiu; Ernest L Mazzaferri
An STS in the human PTC oncogene located at 10q11.2.
Nucleic acids research 1991;19(15):4303.