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Hongbin Ji

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Julian Carretero; Takeshi Shimamura; Klarisa Rikova; Autumn L Jackson; Matthew D Wilkerson; Christa L Borgman; Matthew S Buttarazzi; Benjamin A Sanofsky; Kate McNamara; Kathleyn A Brandstetter; Zandra E Walton; Ting-Lei Gu; Jeffrey C Silva; Katherine Crosby; Geoffrey I Shapiro; Sauveur-Michel Maira; Hongbin Ji; Diego H Castrillon; Carla F Kim; Carlos García-Echeverría; Nabeel Bardeesy; Norman E Sharpless; Neil D Hayes; William Y Kim; Jeffrey A Engelman; Kwok-Kin Wong
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
A McGarry Houghton; Danuta M Rzymkiewicz; Hongbin Ji; Alyssa D Gregory; Eduardo E Egea; Heather E Metz; Donna B Stolz; Stephanie R Land; Luiz A Marconcini; Corrine R Kliment; Kimberly M Jenkins; Keith A Beaulieu; Majd Mouded; Stuart J Frank; Kwok K Wong; Steven D Shapiro
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.
Samanthi A Perera; Danan Li; Takeshi Shimamura; Maria G Raso; Hongbin Ji; Liang Chen; Christa L Borgman; Sara Zaghlul; Kathleyn A Brandstetter; Shigeto Kubo; Masaya Takahashi; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Geoffrey I Shapiro; Heidi Greulich; Matthew Meyerson; Ulrich Guertler; Pilar Garin Chesa; Flavio Solca; Ignacio I Wistuba; Kwok-Kin Wong
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.

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All Publications

2010: Julian Carretero; Takeshi Shimamura; Klarisa Rikova; Autumn L Jackson; Matthew D Wilkerson; Christa L Borgman; Matthew S Buttarazzi; Benjamin A Sanofsky; Kate McNamara; Kathleyn A Brandstetter; Zandra E Walton; Ting-Lei Gu; Jeffrey C Silva; Katherine Crosby; Geoffrey I Shapiro; Sauveur-Michel Maira; Hongbin Ji; Diego H Castrillon; Carla F Kim; Carlos García-Echeverría; Nabeel Bardeesy; Norman E Sharpless; Neil D Hayes; William Y Kim; Jeffrey A Engelman; Kwok-Kin Wong
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
Cancer cell 2010;17(6):547-59.
2010: A McGarry Houghton; Danuta M Rzymkiewicz; Hongbin Ji; Alyssa D Gregory; Eduardo E Egea; Heather E Metz; Donna B Stolz; Stephanie R Land; Luiz A Marconcini; Corrine R Kliment; Kimberly M Jenkins; Keith A Beaulieu; Majd Mouded; Stuart J Frank; Kwok K Wong; Steven D Shapiro
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.
Nature medicine 2010;16(2):219-23.
2009: Samanthi A Perera; Danan Li; Takeshi Shimamura; Maria G Raso; Hongbin Ji; Liang Chen; Christa L Borgman; Sara Zaghlul; Kathleyn A Brandstetter; Shigeto Kubo; Masaya Takahashi; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Geoffrey I Shapiro; Heidi Greulich; Matthew Meyerson; Ulrich Guertler; Pilar Garin Chesa; Flavio Solca; Ignacio I Wistuba; Kwok-Kin Wong
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):474-9.
2008: Takeshi Shimamura; Danan Li; Hongbin Ji; Henry J Haringsma; Elizabeth Liniker; Christa L Borgman; April M Lowell; Yuko Minami; Kate McNamara; Samanthi A Perera; Sara Zaghlul; Roman K Thomas; Heidi Greulich; Susumu Kobayashi; Lucian R Chirieac; Robert F Padera; Shigeto Kubo; Masaya Takahashi; Daniel G Tenen; Matthew Meyerson; Kwok-Kin Wong; Geoffrey I Shapiro
Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
Cancer research 2008;68(14):5827-38.
2008: Xiangzhi Zhou; Haihua Bao; Ruqayyah Al-Hashem; Hongbin Ji; Mitchell S Albert; Kwok-Kin Wong; Yanping Sun
Magnetic resonance imaging of the response of a mouse model of non-small cell lung cancer to tyrosine kinase inhibitor treatment.
Comparative medicine 2008;58(3):276-81.
2007: Danan Li; Takeshi Shimamura; Hongbin Ji; Liang Chen; Henry J Haringsma; Kate McNamara; Mei-Chih Liang; Samanthi A Perera; Sara Zaghlul; Christa L Borgman; Shigeto Kubo; Masaya Takahashi; Yanping Sun; Lucian R Chirieac; Robert F Padera; Neal Lindeman; Pasi A Janne; Roman K Thomas; Matthew Meyerson; Michael J Eck; Jeffrey A Engelman; Geoffrey I Shapiro; Kwok-Kin Wong
Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy.
Cancer cell 2007;12(1):81-93.
2007: Hongbin Ji; Zhenxiong Wang; Samanthi A Perera; Danan Li; Mei-Chih Liang; Sara Zaghlul; Kate McNamara; Liang Chen; Mitchell S Albert; Yanping Sun; Ruqayyah Al-Hashem; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Roman K Thomas; Levi A Garraway; Pasi A Janne; Bruce E Johnson; Lynda Chin; Kwok-Kin Wong
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models.
Cancer research 2007;67(10):4933-9.
2007: Kwok-Kin Wong; richard s maser; E Sahin; S T Bailey; Huili Xia; Hongbin Ji; Kate McNamara; M Naylor; Roderick T Bronson; S Ghosh; R Welsh; Ronald A DePinho
Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.
Oncogene 2007;26(20):2815-21.
2007: Yuki Yuza; Karen A Glatt; Jingrui Jiang; Heidi Greulich; Yuko Minami; Michele S Woo; Takeshi Shimamura; Geoffrey I Shapiro; Jeffrey C Lee; Hongbin Ji; Whei Feng; Tzu-Hsiu Chen; Haruhiko Yanagisawa; Kwok-Kin Wong; Matthew Meyerson
Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors.
Cancer biology & therapy 2007;6(5):661-7.
2007: Danan Li; Hongbin Ji; Sara Zaghlul; Kate McNamara; Mei-Chih Liang; Takeshi Shimamura; Shigeto Kubo; Masaya Takahashi; Lucian R Chirieac; Robert F Padera; Andrew M Scott; Achim A Jungbluth; Webster K Cavenee; Lloyd J Old; George D Demetri; Kwok-Kin Wong
Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas.
The Journal of clinical investigation 2007;117(2):346-52.
2006: Hongbin Ji; Norman E Sharpless; Kwok-Kin Wong
EGFR targeted therapy: view from biological standpoint.
Cell cycle (Georgetown, Tex.) 2006;5(18):2072-6.
2006: Takeshi Shimamura; Hongbin Ji; Yuko Minami; Roman K Thomas; April M Lowell; Kinjal Shah; Heidi Greulich; Karen A Glatt; Matthew Meyerson; Geoffrey I Shapiro; Kwok-Kin Wong
Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272.
Cancer research 2006;66(13):6487-91.
2006: Hongbin Ji; Danan Li; Liang Chen; Takeshi Shimamura; Susumu Kobayashi; Kate McNamara; Umar Mahmood; Albert Mitchell; Yangping Sun; Ruqayyah Al-Hashem; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; William Kim; Pasi A Janne; Geoffrey I Shapiro; Daniel Tenen; Bruce E Johnson; Ralph Weissleder; Norman E Sharpless; Kwok-Kin Wong
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Cancer cell 2006;9(6):485-95.
2006: Hongbin Ji; Xiaojun Zhao; Yuki Yuza; Takeshi Shimamura; Danan Li; Alexei Protopopov; Boonim L Jung; Kate McNamara; Huili Xia; Karen A Glatt; Roman K Thomas; Hidefumi Sasaki; James W Horner; Michael J Eck; Albert Mitchell; Yangping Sun; Ruqayyah Al-Hashem; Roderick T Bronson; Sridhar K Rabindran; Carolyn Discafani; Elizabeth Maher; Geoffrey I Shapiro; Matthew Meyerson; Kwok-Kin Wong
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7817-22.
2006: Hongbin Ji; A McGarry Houghton; T J Mariani; S Perera; Carla F. Kim; Robert F Padera; Giovanni Tonon; Kate McNamara; L A Marconcini; Aram F Hezel; N El-Bardeesy; Roderick T Bronson; D Sugarbaker; richard s maser; Steven D Shapiro; Kwok-Kin Wong
K-ras activation generates an inflammatory response in lung tumors.
Oncogene 2006;25(14):2105-12.
2005: Susumu Kobayashi; Hongbin Ji; Yuki Yuza; Matthew Meyerson; Kwok-Kin Wong; Daniel G Tenen; Balazs Halmos
An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.
Cancer research 2005;65(16):7096-101.
2005: Giovanni Tonon; Kwok-Kin Wong; Gautam Maulik; Cameron Brennan; Bin Feng; Yunyu Zhang; Deepak Khatry; Alexei Protopopov; Mingjian James You; Andrew J Aguirre; Eric S Martin; Zhaohui Yang; Hongbin Ji; Lynda Chin; Ronald A DePinho
High-resolution genomic profiles of human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9625-30.
2005: Giovanni Tonon; Cameron Brennan; Alexei Protopopov; Gautam Maulik; Bin Feng; Yunyu Zhang; Deepak Khatry; Mingjian James You; Andrew J Aguirre; Eric S Martin; Z Yang; Hongbin Ji; Lynda Chin; Kwok-Kin Wong; Ronald A DePinho
Common and contrasting genomic profiles among the major human lung cancer subtypes.
Cold Spring Harbor symposia on quantitative biology 2005;70():11-24.