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M Azuma

Research Profile

Chemicals & Drugs

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TOP 3
Atsuko Fujii; Ayumi Morimoto-Tochigi; Thomas R Shearer; Ryan D Walkup; M Azuma
Lacritin-induced secretion of tear proteins from cultured monkey lacrimal acinar cells.
Emi Nakajima; Thomas R Shearer; Ryan D Walkup; Atsuko Fujii; M Azuma
Pituitary adenylate cyclase-activating peptide induces neurite outgrowth in cultured monkey trigeminal ganglion cells: involvement of receptor PAC1.
Yayoi Kishimoto; Thomas R Shearer; Chiho Yabuta; M Azuma
FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF.

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All Publications

2013: Atsuko Fujii; Ayumi Morimoto-Tochigi; Thomas R Shearer; Ryan D Walkup; M Azuma
Lacritin-induced secretion of tear proteins from cultured monkey lacrimal acinar cells.
Investigative ophthalmology & visual science 2013;54(4):2533-40.
2013: Emi Nakajima; Thomas R Shearer; Ryan D Walkup; Atsuko Fujii; M Azuma
Pituitary adenylate cyclase-activating peptide induces neurite outgrowth in cultured monkey trigeminal ganglion cells: involvement of receptor PAC1.
Molecular vision 2013;19():174-83.
2012: Yayoi Kishimoto; Thomas R Shearer; Chiho Yabuta; M Azuma
FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF.
Investigative ophthalmology & visual science 2012;53(9):5312-9.
2011: Emi Nakajima; Jennifer L Rosales; Thomas R Shearer; Katherine B Hammond; M Azuma
Calpain, not caspase, is the causative protease for hypoxic damage in cultured monkey retinal cells.
Investigative ophthalmology & visual science 2011;52(10):7059-67.
2010: Ayumi Morimoto-Tochigi; Ryan D Walkup; Emi Nakajima; Thomas R Shearer; M Azuma
Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells.
Investigative ophthalmology & visual science 2010;51(9):4395-406.
2009: Emi Nakajima; Larry L David; Michael A Riviere; M Azuma; Thomas R Shearer
Human and monkey lenses cultured with calcium ionophore form alphaB-crystallin lacking the C-terminal lysine, a prominent feature of some human cataracts.
Investigative ophthalmology & visual science 2009;50(12):5828-36.
2009: Hong Ma; Ayumi Tochigi; Thomas R Shearer; M Azuma
Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2009;25(5):409-14.
2009: M Kelly Guyton; Saurav Brahmachari; Arabinda Das; Supriti Samanta Ray; Jun Inoue; M Azuma; Swapan K Ray; Narendra L. Banik
Inhibition of calpain attenuates encephalitogenicity of MBP-specific T cells.
Journal of neurochemistry 2009;110(6):1895-907.
2008: M Azuma; Thomas R Shearer
The role of calcium-activated protease calpain in experimental retinal pathology.
Survey of ophthalmology 2008;53(2):150-63.
2007: Takeshi Nakajima; Ryan D Walkup; A Tochigi; Thomas R Shearer; M Azuma
Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes.
Experimental eye research 2007;85(5):651-8.
2007: Yoshiyuki Tamada; Ryan D Walkup; Thomas R Shearer; M Azuma
Contribution of calpain to cellular damage in human retinal pigment epithelial cells cultured with zinc chelator.
Current eye research 2007;32(6):565-73.
2007: Takayuki Oka; Takeshi Nakajima; Yoshiyuki Tamada; Thomas R Shearer; M Azuma
Contribution of calpains to photoreceptor cell death in N-methyl-N-nitrosourea-treated rats.
Experimental neurology 2007;204(1):39-48.
2007: Chiho Fukiage; Takeshi Nakajima; Yoshiko Takayama; Yoko Minagawa; Thomas R Shearer; M Azuma
PACAP induces neurite outgrowth in cultured trigeminal ganglion cells and recovery of corneal sensitivity after flap surgery in rabbits.
American journal of ophthalmology 2007;143(2):255-262.
2006: Emi Nakajima; Larry L David; Cory Bystrom; Thomas R Shearer; M Azuma
Calpain-specific proteolysis in primate retina: Contribution of calpains in cell death.
Investigative ophthalmology & visual science 2006;47(12):5469-75.
2006: Takayuki Oka; Ryan D Walkup; Yoshiyuki Tamada; Emi Nakajima; A Tochigi; Thomas R Shearer; M Azuma
Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester.
Neuroscience 2006;141(4):2139-45.
2006: Emi Nakajima; Ryan D Walkup; Hong Ma; Thomas R Shearer; M Azuma
Low activity by the calpain system in primate lenses causes resistance to calcium-induced proteolysis.
Experimental eye research 2006;83(3):593-601.
2006: Takayuki Oka; Yoshiyuki Tamada; Emi Nakajima; Thomas R Shearer; M Azuma
Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension.
Journal of neuroscience research 2006;83(7):1342-51.
2006: Takeshi Nakajima; P B Belusko; Ryan D Walkup; M Azuma; Thomas R Shearer
Involvement of Egr-1 in lens epithelial cell death induced by selenite.
Experimental eye research 2006;82(5):874-8.
2006: Marjorie Shih; Hong Ma; Emi Nakajima; Larry L David; M Azuma; Thomas R Shearer
Biochemical properties of lens-specific calpain Lp85.
Experimental eye research 2006;82(1):146-52.
2005: Hong Ma; M Azuma; Thomas R Shearer
Degradation of human aquaporin 0 by m-calpain.
FEBS letters 2005;579(30):6745-8.
2005: Lucinda J G Robertson; Jim D Morton; Masazumi Yamaguchi; Roy Bickerstaffe; Thomas R Shearer; M Azuma
Calpain may contribute to hereditary cataract formation in sheep.
Investigative ophthalmology & visual science 2005;46(12):4634-40.
2005: Miwa Takamure; Ken-Ya Murata; Yoshiyuki Tamada; M Azuma; Satoshi Ueno
Calpain-dependent alpha-fodrin cleavage at the sarcolemma in muscle diseases.
Muscle & nerve 2005;32(3):303-9.
2005: Yoshiyuki Tamada; Emi Nakajima; Takeshi Nakajima; Thomas R Shearer; M Azuma
Proteolysis of neuronal cytoskeletal proteins by calpain contributes to rat retinal cell death induced by hypoxia.
Brain research 2005;1050(1-2):148-55.
2005: Emi Nakajima; Takeshi Nakajima; Yoko Minagawa; Thomas R Shearer; M Azuma
Contribution of ROCK in contraction of trabecular meshwork: proposed mechanism for regulating aqueous outflow in monkey and human eyes.
Journal of pharmaceutical sciences 2005;94(4):701-8.
2004: Hong Ma; Emi Nakajima; Marjorie Shih; M Azuma; Thomas R Shearer
Expression of calpain small subunit 2 in mammalian tissues.
Current eye research 2004;29(4-5):337-47.
2004: M Azuma; Kanako Sakamoto-Mizutani; Takeshi Nakajima; Sayaka Kanaami-Daibo; Yoshiyuki Tamada; Thomas R Shearer
Involvement of calpain isoforms in retinal degeneration in WBN/Kob rats.
Comparative medicine 2004;54(5):533-42.
2004: Takayuki Oka; Thomas R Shearer; M Azuma
Involvement of cyclooxygenase-2 in rat models of conjunctivitis.
Current eye research 2004;29(1):27-34.
2003: P B Belusko; Takeshi Nakajima; M Azuma; Thomas R Shearer
Expression changes in mRNAs and mitochondrial damage in lens epithelial cells with selenite.
Biochimica et biophysica acta 2003;1623(2-3):135-42.
2003: M Azuma; Yoshiyuki Tamada; Sayaka Kanaami; Emi Nakajima; Yoshikuni Nakamura; Chiho Fukiage; Neil E Forsberg; Melinda K Duncan; Thomas R Shearer
Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins.
Biochemical and biophysical research communications 2003;307(3):558-63.
2002: Kanako Sakamoto-Mizutani; Chiho Fukiage; Yoshiyuki Tamada; M Azuma; Thomas R Shearer
Contribution of ubiquitous calpains to cataractogenesis in the spontaneous diabetic WBN/Kob rat.
Experimental eye research 2002;75(5):611-7.
2002: Chiho Fukiage; Emi Nakajima; Hong Ma; M Azuma; Thomas R Shearer
Characterization and regulation of lens-specific calpain Lp82.
The Journal of biological chemistry 2002;277(23):20678-85.
2002: Takeshi Nakajima; Emi Nakajima; Chiho Fukiage; M Azuma; Thomas R Shearer
Differential gene expression in the lens epithelial cells from selenite injected rats.
Experimental eye research 2002;74(2):231-6.
2002: Yoshiyuki Tamada; Chiho Fukiage; Sayaka Daibo; Yukuo Yoshida; M Azuma; Thomas R Shearer
Involvement of calpain in hypoxia-induced damage in rat retina in vitro.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2002;131(2):221-5.
2001: Chiho Fukiage; K Mizutani; Y Kawamoto; M Azuma; Thomas R Shearer
Involvement of phosphorylation of myosin phosphatase by ROCK in trabecular meshwork and ciliary muscle contraction.
Biochemical and biophysical research communications 2001;288(2):296-300.
2001: H Ma; Chiho Fukiage; Y H Kim; Melinda K Duncan; N A Reed; Marjorie Shih; M Azuma; Thomas R Shearer
Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization.
The Journal of biological chemistry 2001;276(30):28525-31.
2001: M Waki; Y Yoshida; T Oka; M Azuma
Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase.
Current eye research 2001;22(6):470-4.
2001: Marjorie Shih; Larry L David; Kirsten J Lampi; H Ma; Chiho Fukiage; M Azuma; Thomas R Shearer
Proteolysis by m-calpain enhances in vitro light scattering by crystallins from human and bovine lenses.
Current eye research 2001;22(6):458-69.
2001: T Nakajima; Chiho Fukiage; M Azuma; H Ma; Thomas R Shearer
Different expression patterns for ubiquitous calpains and Capn3 splice variants in monkey ocular tissues.
Biochimica et biophysica acta 2001;1519(1-2):55-64.
2001: Y Tamada; Chiho Fukiage; K Mizutani; M Yamaguchi; Y Nakamura; M Azuma; Thomas R Shearer
Calpain inhibitor, SJA6017, reduces the rate of formation of selenite cataract in rats.
Current eye research 2001;22(4):280-5.
2001: Y Nakamura; Chiho Fukiage; M Azuma; Thomas R Shearer
Calpain-induced light scattering in young rat lenses is enhanced by UV-B.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2001;17(1):47-58.
2000: H Ma; Marjorie Shih; Chiho Fukiage; M Azuma; Melinda K Duncan; N A Reed; I Richard; Jacques Beckmann; Thomas R Shearer
Influence of specific regions in Lp82 calpain on protein stability, activity, and localization within lens.
Investigative ophthalmology & visual science 2000;41(13):4232-9.
2000: M Azuma; Chiho Fukiage; M Higashine; T Nakajima; Hong Ma; Thomas R Shearer
Identification and characterization of a retina-specific calpain (Rt88) from rat.
Current eye research 2000;21(3):710-20.
2000: Y Tamada; Chiho Fukiage; Y Nakamura; M Azuma; Y H Kim; Thomas R Shearer
Evidence for apoptosis in the selenite rat model of cataract.
Biochemical and biophysical research communications 2000;275(2):300-6.
2000: Y R Sakamoto; T R Nakajima; Chiho Fukiage; O R Sakai; Y R Yoshida; M Azuma; Thomas R Shearer
Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina.
Current eye research 2000;21(1):571-80.
2000: Y Tamada; Chiho Fukiage; D L Boyle; M Azuma; Thomas R Shearer
Involvement of cysteine proteases in bFGF-induced angiogenesis in guinea pig and rat cornea.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2000;16(3):271-83.
2000: Y Nakamura; Chiho Fukiage; Marjorie Shih; H Ma; Larry L David; M Azuma; Thomas R Shearer
Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice.
Investigative ophthalmology & visual science 2000;41(6):1460-6.
2000: H Ma; Marjorie Shih; I Hata; Chiho Fukiage; M Azuma; Thomas R Shearer
Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82.
Current eye research 2000;20(3):183-9.
2000: Thomas R Shearer; H Ma; Marjorie Shih; Chiho Fukiage; M Azuma
Calpains in the lens and cataractogenesis.
Methods in molecular biology (Clifton, N.J.) 2000;144():277-85.
1999: Y Nakamura; Chiho Fukiage; H Ma; Marjorie Shih; M Azuma; Thomas R Shearer
Decreased sensitivity of lens-specific calpain Lp82 to calpastatin inhibitor.
Experimental eye research 1999;69(2):155-62.
1999: Y Nakamura; Chiho Fukiage; M Azuma; Thomas R Shearer
Oxidation enhances calpain-induced turbidity in young rat lenses.
Current eye research 1999;19(1):33-40.
1999: H Ma; I Hata; Marjorie Shih; Chiho Fukiage; Y Nakamura; M Azuma; Thomas R Shearer
Lp82 is the dominant form of calpain in young mouse lens.
Experimental eye research 1999;68(4):447-56.
1998: Thomas R Shearer; H Ma; Marjorie Shih; I Hata; Chiho Fukiage; Y Nakamura; M Azuma
Lp82 calpain during rat lens maturation and cataract formation.
Current eye research 1998;17(11):1037-43.
1998: H Ma; Marjorie Shih; I Hata; Chiho Fukiage; M Azuma; Thomas R Shearer
Protein for Lp82 calpain is expressed and enzymatically active in young rat lens.
Experimental eye research 1998;67(2):221-9.
1998: Kirsten J Lampi; Z Ma; SR Hanson; M Azuma; Marjorie Shih; Thomas R Shearer; David L Smith; Jean B Smith; Larry L David
Age-related changes in human lens crystallins identified by two-dimensional electrophoresis and mass spectrometry.
Experimental eye research 1998;67(1):31-43.
1998: Chiho Fukiage; M Azuma; Y Nakamura; Y Tamada; Thomas R Shearer
Nuclear cataract and light scattering in cultured lenses from guinea pig and rabbit.
Current eye research 1998;17(6):623-35.
1998: H Ma; Chiho Fukiage; M Azuma; Thomas R Shearer
Cloning and expression of mRNA for calpain Lp82 from rat lens: splice variant of p94.
Investigative ophthalmology & visual science 1998;39(2):454-61.
1997: Chiho Fukiage; M Azuma; Y Nakamura; Y Tamada; Thomas R Shearer
Calpain-induced light scattering by crystallins from three rodent species.
Experimental eye research 1997;65(6):757-70.
1997: Chiho Fukiage; M Azuma; Y Nakamura; Y Tamada; M Nakamura; Thomas R Shearer
SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: amelioration of cataract in cultured rat lenses.
Biochimica et biophysica acta 1997;1361(3):304-12.
1997: Thomas R Shearer; H Ma; Chiho Fukiage; M Azuma
Selenite nuclear cataract: review of the model.
Molecular vision 1997;3():8.
1997: M Azuma; Chiho Fukiage; Larry L David; Thomas R Shearer
Activation of calpain in lens: a review and proposed mechanism.
Experimental eye research 1997;64(4):529-38.
1995: Thomas R Shearer; Marjorie Shih; M Azuma; Larry L David
Precipitation of crystallins from young rat lens by endogenous calpain.
Experimental eye research 1995;61(2):141-50.
1995: M Azuma; E Inoue; T Oka; Thomas R Shearer
Proteolysis by calpain is an underlying mechanism for formation of sugar cataract in rat lens.
Current eye research 1995;14(1):27-34.
1994: Larry L David; M Azuma; Thomas R Shearer
Cataract and the acceleration of calpain-induced beta-crystallin insolubilization occurring during normal maturation of rat lens.
Investigative ophthalmology & visual science 1994;35(3):785-93.
1993: K Kadoya; M Azuma; Larry L David; Thomas R Shearer
Role of calpain in hydrogen peroxide induced cataract.
Current eye research 1993;12(4):341-6.
1992: M Azuma; Larry L David; Thomas R Shearer
Superior prevention of calcium ionophore cataract by E64d.
Biochimica et biophysica acta 1992;1180(2):215-20.
1992: Kirsten J Lampi; K Kadoya; M Azuma; Larry L David; Thomas R Shearer
Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses.
Toxicology and applied pharmacology 1992;117(1):53-7.
1992: M Azuma; Thomas R Shearer
Involvement of calpain in diamide-induced cataract in cultured lenses.
FEBS letters 1992;307(3):313-7.
1992: M Azuma; Thomas R Shearer
Induction of elongation in cultured rat lens epithelial cells by FGF and inhibition by selenite.
Investigative ophthalmology & visual science 1992;33(8):2528-31.
1992: M Azuma; R S Anderson; S Sameshima; T Matsumoto; Larry L David; Thomas R Shearer
Calpain in rat cornea.
Investigative ophthalmology & visual science 1992;33(8):2476-82.
1992: Thomas R Shearer; Larry L David; R S Anderson; M Azuma
Review of selenite cataract.
Current eye research 1992;11(4):357-69.
1992: M Azuma; Larry L David; Thomas R Shearer
Hydration and elevated calcium alone do not produce xylose nuclear cataract: role of proteolysis by calpain.
Ophthalmic research 1992;24(1):8-14.
1991: M Azuma; Larry L David; Thomas R Shearer
Cysteine protease inhibitor E64 reduces the rate of formation of selenite cataract in the whole animal.
Current eye research 1991;10(7):657-66.
1991: Thomas R Shearer; M Azuma; Larry L David; T Murachi
Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64.
Investigative ophthalmology & visual science 1991;32(3):533-40.
1990: M Azuma; Thomas R Shearer; T Matsumoto; Larry L David; T Murachi
Calpain II in two in vivo models of sugar cataract.
Experimental eye research 1990;51(4):393-401.
1990: Thomas R Shearer; M Azuma; Larry L David; Y Yamagata; T Murachi
Calpain and calpastatin in rabbit corneal epithelium.
Current eye research 1990;9(1):39-44.