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Zhengfan Jiang

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Huihui Chen; Zhengfan Jiang
The essential adaptors of innate immune signaling.
Xiang Zhou; Fuping You; Huihui Chen; Zhengfan Jiang
Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS).
Huihui Chen; Lu Chen; Jun Gu; Yukun Guan; Delia Gutman; Hiroki Ishikawa; Glen N Barber; Zhihai Qin; Hui Sun; Wenxiang Sun; Hong Tang; Yutao Wang; Weiwei Xia; Jing Yang; Fuping You; Xiang Zhou; Zhengfan Jiang
Activation of STAT6 by STING is critical for antiviral innate immunity.

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All Publications

2013: Huihui Chen; Zhengfan Jiang
The essential adaptors of innate immune signaling.
Protein & cell 2013;4(1):27-39.
2012: Xiang Zhou; Fuping You; Huihui Chen; Zhengfan Jiang
Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS).
Cell research 2012;22(4):717-27.
2011: Huihui Chen; Lu Chen; Jun Gu; Yukun Guan; Delia Gutman; Hiroki Ishikawa; Glen N Barber; Zhihai Qin; Hui Sun; Wenxiang Sun; Hong Tang; Yutao Wang; Weiwei Xia; Jing Yang; Fuping You; Xiang Zhou; Zhengfan Jiang
Activation of STAT6 by STING is critical for antiviral innate immunity.
Cell 2011;147(2):436-46.
2009: Fuping You; Hui Sun; Xiang Zhou; Wenxiang Sun; Shimin Liang; Zhonghe Zhai; Zhengfan Jiang
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.
Nature immunology 2009;10(12):1300-8.
2009: Wenxiang Sun; Yang Li; Lu Chen; Huihui Chen; Fuping You; Xiang Zhou; Yi Zhou; Zhonghe Zhai; Danying Chen; Zhengfan Jiang
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8653-8.
2008: Hui Xiao; Wen Qian; Kirk Staschke; Youcun Qian; Grace Cui; Li Deng; maryam ehsani; Xiliang Wang; Yue-Wei Qian; Zhijian J Chen; Raymond Gilmour; Zhengfan Jiang; Xiaoxia Li
Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation.
The Journal of biological chemistry 2008;283(21):14654-64.
2008: Gernot Schabbauer; James Luyendyk; Karine Crozat; Zhengfan Jiang; Nigel Mackman; Siamak Bahram; Philippe Georgel
TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages.
Molecular immunology 2008;45(10):2790-6.
2007: Motoyuki Otsuka; Qing Jing; Philippe Georgel; Liguo New; Jianming Chen; Johann Mols; Young Jun Kang; Zhengfan Jiang; Xin Du; Ryan Cook; Subash C Das; Asit K Pattnaik; Bruce Beutler; Jiahuai Han
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.
Immunity 2007;27(1):123-34.
2007: Philippe Georgel; Zhengfan Jiang; Stefan Kunz; edith janssen; Johann Mols; Kasper Hoebe; Seiamak Bahram; Michael B A Oldstone; Bruce Beutler
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.
Virology 2007;362(2):304-13.
2007: Jianhong Yao; Tae Whan Kim; Jianzhong Qin; Zhengfan Jiang; Youcun Qian; Hui Xiao; Yi Lu; Wen Qian; Muhammet Fatih Gulen; Nywana Sizemore; Joseph A DiDonato; Shintaro Sato; Shizuo Akira; Bing Su; Xiaoxia Li
Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification.
The Journal of biological chemistry 2007;282(9):6075-89.
2006: Zhengfan Jiang; Philippe Georgel; Chenglong Li; Jungwoo Choe; Karine Crozat; Sophie Rutschmann; Xin Du; Tim Bigby; Suzanne Mudd; Sosathya Sovath; Ian A Wilson; Arthur Olson; Bruce Beutler
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10961-6.
2006: Michael Huber; Christoph Kalis; Simone Keck; Zhengfan Jiang; Philippe Georgel; Xin Du; Louis Shamel; Sosathya Sovath; Suzanne Mudd; Bruce Beutler; Chris Galanos; Marina A Freudenberg
R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells.
European journal of immunology 2006;36(3):701-11.
2006: Kasper Hoebe; Zhengfan Jiang; Philippe Georgel; Koichi Tabeta; edith janssen; Xin Du; Bruce Beutler
TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy.
Current pharmaceutical design 2006;12(32):4123-34.
2006: Kasper Hoebe; Zhengfan Jiang; Koichi Tabeta; Xin Du; Philippe Georgel; Karine Crozat; Bruce Beutler
Genetic analysis of innate immunity.
Advances in immunology 2006;91():175-226.
2006: Bruce Beutler; Zhengfan Jiang; Philippe Georgel; Karine Crozat; Ben A Croker; Sophie Rutschmann; Xin Du; Kasper Hoebe
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.
Annual review of immunology 2006;24():353-89.
2005: Bruce Beutler; Philippe Georgel; Sophie Rutschmann; Zhengfan Jiang; Ben A Croker; Karine Crozat
Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV).
Briefings in functional genomics & proteomics 2005;4(3):203-13.
2005: Philippe Georgel; Karine Crozat; Xavier Lauth; Evgenia Makrantonaki; Holger Seltmann; Sosathya Sovath; Kasper Hoebe; Xin Du; Sophie Rutschmann; Zhengfan Jiang; Timothy Bigby; Victor Nizet; Christos Zouboulis; Bruce Beutler
A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.
Infection and immunity 2005;73(8):4512-21.
2005: Zhengfan Jiang; Philippe Georgel; Xin Du; Louis Shamel; Sosathya Sovath; Suzanne Mudd; Michael Huber; Christoph Kalis; Simone Keck; Chris Galanos; Marina A Freudenberg; Bruce Beutler
CD14 is required for MyD88-independent LPS signaling.
Nature immunology 2005;6(6):565-70.
2005: Zuping Zhou; Kasper Hoebe; Xin Du; Zhengfan Jiang; Louis Shamel; Bruce Beutler
Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation.
European journal of immunology 2005;35(6):1918-27.
2004: Aristóbolo M Silva; Mark Whitmore; Zan Xu; Zhengfan Jiang; Xiaoxia Li; Bryan R G Williams
Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.
The Journal of biological chemistry 2004;279(36):37670-6.
2004: Jianzhong Qin; Zhengfan Jiang; Youcun Qian; Jean-Laurent Casanova; Xiaoxia Li
IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness.
The Journal of biological chemistry 2004;279(25):26748-53.
2004: Zhengfan Jiang; Tak W Mak; Ganes Sen; Xiaoxia Li
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3533-8.
2004: Ge Jin; Alison Klika; Michelle Callahan; Ben Faga; Joel Danzig; Zhengfan Jiang; Xiaoxia Li; George R Stark; John Harrington; Bruce Sherf
Identification of a human NF-kappaB-activating protein, TAB3.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2028-33.
2003: Zhengfan Jiang; Maryam Zamanian-Daryoush; Huiqing Nie; Aristóbolo M Silva; Bryan R G Williams; Xiaoxia Li
Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .
The Journal of biological chemistry 2003;278(19):16713-9.
2003: Hannah Nguyen; Moitreyee Chatterjee-Kishore; Zhengfan Jiang; Yulan Qing; chilakamarti ramana; Joshua Bayes; Mairead Commane; Xiaoxia Li; George R Stark
IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003;23(4):183-92.
2003: Zhengfan Jiang; H Jan Johnson; Huiqing Nie; Jianzhong Qin; Timothy A Bird; Xiaoxia Li
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.
The Journal of biological chemistry 2003;278(13):10952-6.
2002: Zhengfan Jiang; Jun Ninomiya-Tsuji; Youcun Qian; Kunihiro Matsumoto; Xiaoxia Li
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.
Molecular and cellular biology 2002;22(20):7158-67.
2002: Youcun Qian; Zhendong Zhao; Zhengfan Jiang; Xiaoxia Li
Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9386-91.
2001: Xiaoxia Li; Mairead Commane; Zhengfan Jiang; George R Stark
IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4461-5.