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Ignacio Jiménez

Research Profile

Chemicals & Drugs

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Physiology

Multiple Drug Resistance

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Magnetic Resonance Spectroscopy

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Publications

TOP 3
Alejandro E Ardiles; Agueda González-Rodríguez; Ignacio A Jiménez; Marvin J Núñez; Virginia Pardo; Nayra R Perestelo; Angela M Valverde; Isabel L Bazzocchi
Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus.
Gabriel G Llanos; Laila Moujir; Liliana M Araujo; Ignacio A Jiménez; Isabel L Bazzocchi
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells.
Alex A Osorio; Nayra R Perestelo; David Torres-Romero; José Alcamí; Luis M Bedoya; Ignacio A Jiménez; Alejandro Muñóz; Isabel L Bazzocchi
Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription.

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All Publications

2012: Alejandro E Ardiles; Agueda González-Rodríguez; Ignacio A Jiménez; Marvin J Núñez; Virginia Pardo; Nayra R Perestelo; Angela M Valverde; Isabel L Bazzocchi
Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus.
Phytochemistry 2012;84():116-24.
2012: Gabriel G Llanos; Laila Moujir; Liliana M Araujo; Ignacio A Jiménez; Isabel L Bazzocchi
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells.
European journal of medicinal chemistry 2012;54():499-511.
2012: Alex A Osorio; Nayra R Perestelo; David Torres-Romero; José Alcamí; Luis M Bedoya; Ignacio A Jiménez; Alejandro Muñóz; Isabel L Bazzocchi
Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription.
European journal of medicinal chemistry 2012;52():295-303.
2011: Nayra R Perestelo; María P Sánchez-Cañete; Santiago Castanys; Francisco Gamarro; Ignacio A Jiménez; Isabel L Bazzocchi
Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-β-agarofuran sesquiterpenes.
European journal of medicinal chemistry 2011;46(10):4915-23.
2011: David Torres-Romero; Ignacio A Jiménez; Rosario Rojas; Robert H Gilman; Matías López; Isabel L Bazzocchi
Dihydro-β-agarofuran sesquiterpenes isolated from Celastrus vulcanicola as potential anti-Mycobacterium tuberculosis multidrug-resistant agents.
Bioorganic & medicinal chemistry 2011;19(7):2182-9.
2011: Marvin J Núñez; Carolina P Reyes; Ignacio A Jiménez; Hirotaka Hayashi; Harukuni Tokuda; Isabel L Bazzocchi
ent-Rosane and abietane diterpenoids as cancer chemopreventive agents.
Phytochemistry 2011;72(4-5):385-90.
2011: María L Kennedy; Fernando Cortés; José E Piñero; Santiago Castanys; Atteneri López-Arencibia; Francisco Gamarro; Isabel L Bazzocchi; Ignacio A Jiménez
Leishmanicidal and reversal multidrug resistance constituents from Aeonium lindleyi.
Planta medica 2011;77(1):77-80.
2010: Gabriel G Llanos; Liliana M Araujo; Ignacio A Jiménez; Laila M Moujir; Jesús T Vázquez; Isabel L Bazzocchi
Withanolides from Withania aristata and their cytotoxic activity.
Steroids 2010;75(12):974-81.
2010: Gabriel G Llanos; Rosa M Varela; Ignacio A Jiménez; José M G Molinillo; Francisco A Macías; Isabel L Bazzocchi
Metabolites from Withania aristata with potential phytotoxic activity.
Natural product communications 2010;5(7):1043-7.
2009: Ninoska Flores; Ignacio A Jiménez; Alberto Giménez; Grace Ruiz; David Gutiérrez; Genevieve Bourdy; Isabel L Bazzocchi
Antiparasitic activity of prenylated benzoic acid derivatives from Piper species.
Phytochemistry 2009;70(5):621-7.
2008: Ninoska Flores; Ignacio A Jiménez; Alberto Giménez; Grace Ruiz; David Gutiérrez; Genevieve Bourdy; Isabel L Bazzocchi
Benzoic acid derivatives from Piper species and their antiparasitic activity.
Journal of natural products 2008;71(9):1538-43.
2008: David Torres-Romero; Beatriz King-Díaz; Ignacio A Jiménez; Blas Lotina-Hennsen; Isabel L Bazzocchi
Sesquiterpenes from Celastrus vulcanicola as photosynthetic inhibitors.
Journal of natural products 2008;71(8):1331-5.
2007: Carolina perez reyes; Francisco Muñoz-Martínez; Ivan Rodriguez Torrecillas; Cristina R Mendoza; Francisco Gamarro; Isabel L Bazzocchi; Marvin J Núñez; Leonardo Pardo; Santiago Castanys; Mercedes Campillo; Ignacio A Jiménez
Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.
Journal of medicinal chemistry 2007;50(20):4808-17.
2007: Ninoska Flores; Gabriela Cabrera; Ignacio A Jiménez; José E Piñero; Alberto Giménez; Genevieve Bourdy; Fernando Cortés-Selva; Isabel L Bazzocchi
Leishmanicidal constituents from the leaves of Piper rusbyi.
Planta medica 2007;73(3):206-11.
2006: José E Piñero; Rosane M Temporal; Antonio J Silva-Gonçalves; Ignacio A Jiménez; Isabel L Bazzocchi; Alexis Oliva; Antonio Perera; Leonor L Leon; Basilio Valladares
New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis.
Acta tropica 2006;98(1):59-65.
2006: Carolina perez reyes; Marvin J Núñez; Ignacio A Jiménez; Jérôme Busserolles; María José Alcaraz; Isabel L Bazzocchi
Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2.
Bioorganic & medicinal chemistry 2006;14(5):1573-9.
2006: Francisco Muñoz-Martínez; Carolina perez reyes; Antonio L Pérez-Lomas; Ignacio A Jiménez; Francisco Gamarro; Santiago Castanys
Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.
Biochimica et biophysica acta 2006;1758(1):98-110.
2005: Marvin J Núñez; Carolina perez reyes; Ignacio A Jiménez; Laila Moujir; Isabel L Bazzocchi
Lupane triterpenoids from Maytenus species.
Journal of natural products 2005;68(7):1018-21.
2005: Francisco Muñoz-Martínez; Cristina R Mendoza; Isabel L Bazzocchi; Santiago Castanys; Ignacio A Jiménez; Francisco Gamarro
Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis.
Journal of medicinal chemistry 2005;48(13):4266-75.
2005: Cristina R Mendoza; Ignacio A Jiménez; Harukuni Tokuda; Hiroyuki Kushida; Isabel L Bazzocchi
Antitumor-promoting effects of new sesquiterpenes from Crossopetalum tonduzii.
Chemistry & biodiversity 2005;2(2):286-94.
2005: Fernando Cortés-Selva; Ignacio A Jiménez; F Munoz-Martínez; Mercedes Campillo; Isabel L Bazzocchi; Leonardo Pardo; Angel G Ravelo; Santiago Castanys; Francisco Gamarro
Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.
Current pharmaceutical design 2005;11(24):3125-39.
2004: Francisco Muñoz-Martínez; Peihua Lu; Fernando Cortés-Selva; José M Pérez-Victoria; Ignacio A Jiménez; Angel G Ravelo; Frances Sharom; Francisco Gamarro; Santiago Castanys
Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.
Cancer research 2004;64(19):7130-8.
2004: Fernando Cortés-Selva; Mercedes Campillo; Carolina perez reyes; Ignacio A Jiménez; Santiago Castanys; Isabel L Bazzocchi; Leonardo Pardo; Francisco Gamarro; Angel G Ravelo
SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter.
Journal of medicinal chemistry 2004;47(3):576-87.
2004: Marvin J Núñez; Ana Guadaño; Ignacio A Jiménez; Angel G Ravelo; Azucena González-Coloma; Isabel L Bazzocchi
Insecticidal sesquiterpene pyridine alkaloids from Maytenus chiapensis.
Journal of natural products 2004;67(1):14-8.
2003: Alicia Hermoso; Ignacio A Jiménez; Zulma A Mamani; Isabel L Bazzocchi; José E Piñero; Angel G Ravelo; Basilio Valladares
Antileishmanial activities of dihydrochalcones from piper elongatum and synthetic related compounds. Structural requirements for activity.
Bioorganic & medicinal chemistry 2003;11(18):3975-80.
2003: Ignacio A Jiménez; Isabel L Bazzocchi; Marvin J Núñez; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Takao Konoshima; Angel G Ravelo
Absolute configuration of sesquiterpenes from Crossopetalum tonduzii and their inhibitory effects on Epstein-Barr virus early antigen activation in Raji cells.
Journal of natural products 2003;66(8):1047-50.
2003: Marvin J Núñez; Fernando Cortés-Selva; Isabel L Bazzocchi; Ignacio A Jiménez; Antonio G González; Angel G Ravelo; José A Gavin
Absolute configuration and complete assignment of 13C NMR data for new sesquiterpenes from Maytenus chiapensis.
Journal of natural products 2003;66(4):572-4.
2002: Benigna M Tincusi; Ignacio A Jiménez; Isabel L Bazzocchi; Laila Moujir; Zulma A Mamani; José P Barroso; Angel G Ravelo; Basilio V Hernández
Antimicrobial terpenoids from the oleoresin of the Peruvian medicinal plant Copaifera paupera.
Planta medica 2002;68(9):808-12.
2001: M L Kennedy; Fernando Cortés-Selva; José M Pérez-Victoria; Ignacio A Jiménez; Antonio G González; Orlando Muñoz; Francisco Gamarro; Santiago Castanys; Angel G Ravelo
Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis.
Journal of medicinal chemistry 2001;44(26):4668-76.
2001: José M Pérez-Victoria; F Javier Pérez-Victoria; Adriana Parodi-Talice; Ignacio A Jiménez; Angel G Ravelo; Santiago Castanys; Francisco Gamarro
Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator.
Antimicrobial agents and chemotherapy 2001;45(9):2468-74.
2000: Antonio G González; Benigna M Tincusi; Isabel L Bazzocchi; Harukuni Tokuda; Hoyoku Nishino; Takao Konoshima; Ignacio A Jiménez; Angel G Ravelo
Anti-tumor promoting effects of sesquiterpenes from Maytenus cuzcoina (Celastraceae).
Bioorganic & medicinal chemistry 2000;8(7):1773-8.
1999: José M Pérez-Victoria; Benigna M Tincusi; Ignacio A Jiménez; Isabel L Bazzocchi; M P Gupta; Santiago Castanys; Francisco Gamarro; Angel G Ravelo
New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line.
Journal of medicinal chemistry 1999;42(21):4388-93.
1998: Benigna M Tincusi; Ignacio A Jiménez; Angel G Ravelo; R Missico
New sesquiterpenes from Crossopetalum tonduzii.
Journal of natural products 1998;61(12):1520-3.