Guixian Jin

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Cole Derek C; Stock Joseph R; Chopra Rajiv; Cowling Rebecca; Ellingboe John W; Fan Kristi Y; Harrison Boyd L; Hu Yun; Jacobsen Steve; Jennings Lee D; Jin Guixian; Lohse Peter A; Malamas Michael S; Manas Eric S; Moore William J; O'Donnell Mary-Margaret; Olland Andrea M; Robichaud Albert J; Svenson Kristine; Wu JunJun; Wagner Eric; Bard Jonathan
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Jennings Lee D; Cole Derek C; Stock Joseph R; Sukhdeo Mohani N; Ellingboe John W; Cowling Rebecca; Jin Guixian; Manas Eric S; Fan Kristi Y; Malamas Michael S; Harrison Boyd L; Jacobsen Steve; Chopra Rajiv; Lohse Peter A; Moore William J; O'Donnell Mary-Margaret; Hu Yun; Robichaud Albert J; Turner M James; Wagner Erik; Bard Jonathan
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.
Fobare William F; Solvibile William R; Robichaud Albert J; Malamas Michael S; Manas Eric; Turner Jim; Hu Yun; Wagner Erik; Chopra Rajiv; Cowling Rebecca; Jin Guixan; Bard Jonathan
Thiophene substituted acylguanidines as BACE1 inhibitors.

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All Publications

2008: Cole Derek C; Stock Joseph R; Chopra Rajiv; Cowling Rebecca; Ellingboe John W; Fan Kristi Y; Harrison Boyd L; Hu Yun; Jacobsen Steve; Jennings Lee D; Jin Guixian; Lohse Peter A; Malamas Michael S; Manas Eric S; Moore William J; O'Donnell Mary-Margaret; Olland Andrea M; Robichaud Albert J; Svenson Kristine; Wu JunJun; Wagner Eric; Bard Jonathan
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Bioorganic & medicinal chemistry letters 2008;18(3):1063-6.
2008: Jennings Lee D; Cole Derek C; Stock Joseph R; Sukhdeo Mohani N; Ellingboe John W; Cowling Rebecca; Jin Guixian; Manas Eric S; Fan Kristi Y; Malamas Michael S; Harrison Boyd L; Jacobsen Steve; Chopra Rajiv; Lohse Peter A; Moore William J; O'Donnell Mary-Margaret; Hu Yun; Robichaud Albert J; Turner M James; Wagner Erik; Bard Jonathan
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.
Bioorganic & medicinal chemistry letters 2008;18(2):767-71.
2007: Fobare William F; Solvibile William R; Robichaud Albert J; Malamas Michael S; Manas Eric; Turner Jim; Hu Yun; Wagner Erik; Chopra Rajiv; Cowling Rebecca; Jin Guixan; Bard Jonathan
Thiophene substituted acylguanidines as BACE1 inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(19):5353-6.
2006: Jin Guixian; Aulabaugh Ann; Pocas Jennifer; Liu Hao; Kriz Ron; Sampath Deepak
Development and comparison of nonradioactive in vitro kinase assays for NIMA-related kinase 2.
Analytical biochemistry 2006;358(1):59-69.
2006: Cole Derek C; Manas Eric S; Stock Joseph R; Condon Jeffrey S; Jennings Lee D; Aulabaugh Ann; Chopra Rajiv; Cowling Rebecca; Ellingboe John W; Fan Kristi Y; Harrison Boyd L; Hu Yun; Jacobsen Steve; Jin Guixan; Lin Laura; Lovering Frank E; Malamas Michael S; Stahl Mark L; Strand James; Sukhdeo Mohani N; Svenson Kristine; Turner M James; Wagner Erik; Wu Junjun; Zhou Ping; Bard Jonathan
Acylguanidines as small-molecule beta-secretase inhibitors.
Journal of medicinal chemistry 2006;49(21):6158-61.
2006: Bridges Kristie Grove; Chopra Rajiv; Lin Laura; Svenson Kristine; Tam Amy; Jin Guixian; Cowling Rebecca; Lovering Frank; Akopian Tatos N; DiBlasio-Smith Elizabeth; Annis-Freeman Bethany; Marvell Tod H; LaVallie Edward R; Zollner Richard S; Bard Jonathan; Somers William S; Stahl Mark L; Kriz Ronald W
A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.
Peptides 2006;27(7):1877-85.
2006: Levin J I; Chen J M; Laakso L M; Du M; Schmid J; Xu W; Cummons T; Xu J; Jin G; Barone D; Skotnicki J S
Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2006;16(6):1605-9.
2005: Zask Arie; Kaplan Joshua; Du XueMei; MacEwan Gloria; Sandanayaka Vincent; Eudy Nancy; Levin Jeremy; Jin Guixian; Xu Jun; Cummons Terri; Barone Dauphine; Ayral-Kaloustian Semiramis; Skotnicki Jerauld
Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(6):1641-5.
2004: Venkatesan Aranapakam M; Davis Jamie M; Grosu George T; Baker Jannie; Zask Arie; Levin Jeremy I; Ellingboe John; Skotnicki Jerauld S; Dijoseph John F; Sung Amy; Jin Guixian; Xu Weixin; McCarthy Diane Joseph; Barone Dauphine
Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(25):6255-69.
2004: Zhang Yuhua; Hegen Martin; Xu Jun; Keith James C; Jin Guixian; Du Xuemei; Cummons Terri; Sheppard Barbara J; Sun LinHong; Zhu Yi; Rao Vikram R; Wang Qin; Xu Weixin; Cowling Rebecca; Nickerson-Nutter Cheryl L; Gibbons Jay; Skotnicki Jerry; Lin Lih-Ling; Levin Jeremy
Characterization of (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-alpha converting enzyme.
International immunopharmacology 2004;4(14):1845-57.
2004: Lo Mei-Chu; Aulabaugh Ann; Jin Guixian; Cowling Rebecca; Bard Jonathan; Malamas Michael; Ellestad George
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery.
Analytical biochemistry 2004;332(1):153-9.
2004: Levin Jeremy I; Nelson Frances C; Delos Santos Efren; Du Mila T; MacEwan Gloria; Chen James M; Ayral-Kaloustian Semiramis; Xu Jun; Jin Guixian; Cummons Terri; Barone Dauphine
Benzodiazepine inhibitors of the MMPs and TACE. Part 2.
Bioorganic & medicinal chemistry letters 2004;14(16):4147-51.
2004: Hu Baihua; Fan Kristi Yi; Bridges Kristie; Chopra Rajiv; Lovering Frank; Cole Derek; Zhou Ping; Ellingboe John; Jin Guixiang; Cowling Rebecca; Bard Jonathan
Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(13):3457-60.
2003: Levin J I; Chen J M; Cheung K; Cole D; Crago C; Santos E Delos; Du X; Khafizova G; MacEwan G; Niu C; Salaski E J; Zask A; Cummons T; Sung A; Xu J; Zhang Y; Xu W; Ayral-Kaloustian S; Jin G; Cowling R; Barone D; Mohler K M; Black R A; Skotnicki J S
Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2003;13(16):2799-803.
2003: Aranapakam Venkatesan; Davis Jamie M; Grosu George T; Baker Jannie; Ellingboe John; Zask Arie; Levin Jeremy I; Sandanayaka Vincent P; Du Mila; Skotnicki Jerauld S; DiJoseph John F; Sung Amy; Sharr Michele A; Killar Loran M; Walter Thomas; Jin Guixian; Cowling Rebecca; Tillett Jeff; Zhao Weiguang; McDevitt Joseph; Xu Zhang Bao
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2376-96.
2003: Aranapakam Venkatesan; Grosu George T; Davis Jamie M; Hu Baihua; Ellingboe John; Baker Jannie L; Skotnicki Jerauld S; Zask Arie; DiJoseph John F; Sung Amy; Sharr Michele A; Killar Loran M; Walter Thomas; Jin Guixian; Cowling Rebecca
Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2361-75.
2003: Zask A; Gu Y; Albright J D; Du X; Hogan M; Levin J I; Chen J M; Killar L M; Sung A; DiJoseph J F; Sharr M A; Roth C E; Skala S; Jin G; Cowling R; Mohler K M; Barone D; Black R; March C; Skotnicki J S
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(8):1487-90.
2002: Nelson Frances C; Delos Santos Efren; Levin Jeremy I; Chen James M; Skotnicki Jerauld S; DiJoseph John F; Sharr Michele A; Sung Amy; Killar Loran M; Cowling Rebecca; Jin Guixian; Roth Catherine E; Albright J Donald
Benzodiazepine inhibitors of the MMPs and TACE.
Bioorganic & medicinal chemistry letters 2002;12(20):2867-70.
2002: Levin J I; Chen J M; Du M T; Nelson F C; Killar L M; Skala S; Sung A; Jin G; Cowling R; Barone D; March C J; Mohler K M; Black R A; Skotnicki J S
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group.
Bioorganic & medicinal chemistry letters 2002;12(8):1199-202.
2002: Chen James M; Jin Guixian; Sung Amy; Levin Jeremy I
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 1: Structure-based design of novel acetylenic P1' groups.
Bioorganic & medicinal chemistry letters 2002;12(8):1195-8.
2002: Jin Guixian; Huang Xinyi; Black Roy; Wolfson Martin; Rauch Charles; McGregor Herbert; Ellestad George; Cowling Rebecca
A continuous fluorimetric assay for tumor necrosis factor-alpha converting enzyme.
Analytical biochemistry 2002;302(2):269-75.
2001: Levin J I; Chen J M; Du M T; Nelson F C; Wehr T; DiJoseph J F; Killar L M; Skala S; Sung A; Sharr M A; Roth C E; Jin G; Cowling R; Di L; Sherman M; Xu Z B; March C J; Mohler K M; Black R A; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.
Bioorganic & medicinal chemistry letters 2001;11(22):2975-8.
2001: Levin J I; Chen J; Du M; Hogan M; Kincaid S; Nelson F C; Venkatesan A M; Wehr T; Zask A; DiJoseph J; Killar L M; Skala S; Sung A; Sharr M; Roth C; Jin G; Cowling R; Mohler K M; Black R A; March C J; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.
Bioorganic & medicinal chemistry letters 2001;11(16):2189-92.
2001: Levin J I; Gu Y; Nelson F C; Zask A; DiJoseph J F; Sharr M A; Sung A; Jin G; Cowling R; Chanda P; Cosmi S; Hsiao C L; Edris W; Wilhelm J; Killar L M; Skotnicki J S
Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 2001;11(2):239-42.
2001: Levin J I; Du M T; DiJoseph J F; Killar L M; Sung A; Walter T; Sharr M A; Roth C E; Moy F J; Powers R; Jin G; Cowling R; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.
Bioorganic & medicinal chemistry letters 2001;11(2):235-8.

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Guixian Jin

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