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Randy Jirtle

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Autumn J Bernal; Dana C Dolinoy; Dale Huang; David A Skaar; Caren Weinhouse; Randy L Jirtle
Adaptive radiation-induced epigenetic alterations mitigated by antioxidants.
Sharon A Meyer; Randy L Jirtle
Old Dance with a New Partner: EGF Receptor as the Phenobarbital Receptor Mediating Cyp2B Expression.
Adelheid Soubry; Frances Wang; Autumn Bernal; Zhiqing Huang; Randy L Jirtle; Joanne Kurtzberg; Susan Murphy; Amy P Murtha; Joellen M Schildkraut; Cathrine Hoyo
Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort.

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2013: Autumn J Bernal; Dana C Dolinoy; Dale Huang; David A Skaar; Caren Weinhouse; Randy L Jirtle
Adaptive radiation-induced epigenetic alterations mitigated by antioxidants.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(2):665-71.
2013: Sharon A Meyer; Randy L Jirtle
Old Dance with a New Partner: EGF Receptor as the Phenobarbital Receptor Mediating Cyp2B Expression.
Science signaling 2013;6(274):pe16.
2013: Adelheid Soubry; Frances Wang; Autumn Bernal; Zhiqing Huang; Randy L Jirtle; Joanne Kurtzberg; Susan Murphy; Amy P Murtha; Joellen M Schildkraut; Cathrine Hoyo
Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort.
BMC medicine 2013;11():29.
2012: Ellen Perkins; Joellen Schildkraut; Wendy Demark-Wahnefried; Michele R Forman; Zhiqing Huang; Randy L Jirtle; Joanne Kurtzberg; Susan Murphy; Amy P Murtha; Francine Overcash; Cathrine Hoyo
Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.
The Journal of pediatrics 2012;161(1):31-9.
2012: Cathrine Hoyo; Zhiqing Huang; Randy L Jirtle; Joanne Kurtzberg; Amy P Murtha; Francine Overcash; Joellen M Schildkraut; Adelheid Soubry; Wendy Demark-Wahnefried; Michele R Forman; Kimberly Fortner; Susan Murphy
Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight.
Cancer causes & control : CCC 2012;23(4):635-45.
2012: Jennifer L Stone; David A Skaar; Justin M Bradshaw; Randy L Jirtle; Ruth E McMillan; Michael L Sikes
DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(5):2266-75.
2012: Susan Murphy; Amy P Murtha; Francine Overcash; Joellen M Schildkraut; Frances Wang; Abayomi Adigun; Zhiqing Huang; Edwin S Iversen; Randy L Jirtle; Cathrine Hoyo
Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke.
Gene 2012;494(1):36-43.
2012: Radhika Das; John M Greally; Nathan Anderson; Michael Kamal; Maryellen I Koran; Kerstin Linblad-Toh; Tarjei S Mikkelsen; Susan K Murphy; Jennifer R Weidman; Randy L Jirtle
Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.
BMC genomics 2012;13():394.
2011: Caren Weinhouse; Olivia S Anderson; Randy L Jirtle; Tamara R Jones; Jung Kim; Shayna A Liberman; Muna S Nahar; Laura S Rozek; Dana C Dolinoy
An expression microarray approach for the identification of metastable epialleles in the mouse genome.
Epigenetics : official journal of the DNA Methylation Society 2011;6(9):1105-13.
2011: Cathrine Hoyo; Zhiqing Huang; Edwin S Iversen; Randy L Jirtle; Joanne Kurtzberg; Wendy Demark-Wahnefried; Michele R Forman; Amy P Murtha; Francine Overcash; Joellen M Schildkraut; Susan Murphy
Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.
Epigenetics : official journal of the DNA Methylation Society 2011;6(7):928-36.
2011: Aiping Zhang; Dale Huang; Yue Li; Susan Murphy; Thomas M Price; David A Skaar; Randy L Jirtle
Novel retrotransposed imprinted locus identified at human 6p25.
Nucleic acids research 2011;39(13):5388-400.
2011: Cathrine Hoyo; Amy P Murtha; Joellen M Schildkraut; Michele R Forman; Brian Calingaert; Wendy Demark-Wahnefried; Joanne Kurtzberg; Randy L Jirtle; Susan Murphy
Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).
BMC public health 2011;11(1):46.
2010: Hyeon-Sook Suh; Melissa A Cosenza-Nashat; Namjong Choi; Meng-Liang Zhao; Jiu-feng Li; Jeffrey W Pollard; Randy L Jirtle; Harris Goldstein; Sunhee C Lee
Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders.
The American journal of pathology 2010;177(5):2446-58.
2010: Dana C Dolinoy; Caren Weinhouse; Tamara R Jones; Laura S Rozek; Randy L Jirtle
Variable histone modifications at the A(vy) metastable epiallele.
Epigenetics : official journal of the DNA Methylation Society 2010;5(7):637-44.
2010: Autumn J Bernal; Randy L Jirtle
Epigenomic disruption: the effects of early developmental exposures.
Birth defects research. Part A, Clinical and molecular teratology 2010;88(10):938-44.
2009: Cathrine Hoyo; Joellen M Schildkraut; Susan Murphy; Wong-Ho Chow; Thomas L Vaughan; Harvey Risch; Jeffrey R Marks; Randy L Jirtle; Brian Calingaert; Brian Calingeart; Susan Mayne; Joseph Fraumeni; Marilie D Gammon
IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas.
International journal of cancer. Journal international du cancer 2009;125(11):2673-8.
2009: Randy L Jirtle
Epigenome: the program for human health and disease.
Epigenomics 2009;1(1):13-6.
2009: Radhika Das; Daniel D Hampton; Randy L Jirtle
Imprinting evolution and human health.
Mammalian genome : official journal of the International Mammalian Genome Society 2009;20(9-10):563-72.
2009: Cathrine Hoyo; Susan Murphy; Randy L Jirtle
Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.
Journal of epidemiology and community health 2009;63(9):683-4.
2008: Randy L Jirtle
Randy L. Jirtle, PhD: epigenetics a window on gene dysregulation, disease. Interview by Bridget M. Kuehn.
JAMA : the journal of the American Medical Association 2008;299(11):1249-50.
2008: Hong Seok Jang; Ki Mun Kang; Byung Ock Choi; Gyu Young Chai; Soon-Chan Hong; Woo Song Ha; Randy L Jirtle
Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma.
World journal of gastroenterology : WJG 2008;14(9):1394-8.
2008: Dana C Dolinoy; Randy L Jirtle
Environmental epigenomics in human health and disease.
Environmental and molecular mutagenesis 2008;49(1):4-8.
2007: Philippe P Luedi; Fred S Dietrich; Jennifer R Weidman; Jason M Bosko; Randy L Jirtle; Alexander J Hartemink
Computational and experimental identification of novel human imprinted genes.
Genome research 2007;17(12):1723-30.
2007: Dana C Dolinoy; Dale Huang; Randy L Jirtle
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13056-61.
2007: Dana C Dolinoy; Radhika Das; Jennifer R Weidman; Randy L Jirtle
Metastable epialleles, imprinting, and the fetal origins of adult diseases.
Pediatric research 2007;61(5 Pt 2):30R-37R.
2007: Randy L Jirtle; Michael Skinner
Environmental epigenomics and disease susceptibility.
Nature reviews. Genetics 2007;8(4):253-62.
2007: Dana C Dolinoy; Jennifer R Weidman; Randy L Jirtle
Epigenetic gene regulation: linking early developmental environment to adult disease.
Reproductive toxicology (Elmsford, N.Y.) 2007;23(3):297-307.
2007: Y A Bobetsis; Silvana P Barros; DM Lin; Jennifer R Weidman; Dana C Dolinoy; Randy L Jirtle; Kim A Boggess; James Beck; Steven Offenbacher
Bacterial infection promotes DNA hypermethylation.
Journal of dental research 2007;86(2):169-74.
2007: Jennifer R Weidman; Dana C Dolinoy; Susan Murphy; Randy L Jirtle
Cancer susceptibility: epigenetic manifestation of environmental exposures.
Cancer journal (Sudbury, Mass.) 2007;13(1):9-16.
2007: Alexander I Shevchenko; Irina S Zakharova; Eugeny A Elisaphenko; Nicolay N Kolesnikov; Siobhan Whitehead; Christine Bird; Mark Ross; Jennifer R Weidman; Randy L Jirtle; Tatiana V Karamysheva; Nikolai Rubtsov; John VandeBerg; Nina A Mazurok; Tatyana B Nesterova; Neil Brockdorff; Suren M Zakian
Genes flanking Xist in mouse and human are separated on the X chromosome in American marsupials.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2007;15(2):127-36.
2006: Rodger A Liddle; Randy L Jirtle
Epigenetic silencing of genes in human colon cancer.
Gastroenterology 2006;131(3):960-2.
2006: Dana C Dolinoy; Jennifer R Weidman; Robert A Waterland; Randy L Jirtle
Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome.
Environmental health perspectives 2006;114(4):567-72.
2006: Robert A Waterland; Juan-Ru Lin; Charlotte A Smith; Randy L Jirtle
Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus.
Human molecular genetics 2006;15(5):705-16.
2006: Susan Murphy; Catherine M Nolan; Zhiqing Huang; Katerina S Kucera; Brad A Freking; Timothy P L Smith; Kreg A Leymaster; Jennifer R Weidman; Randy L Jirtle
Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.
Genome research 2006;16(3):340-6.
2006: Catherine M Nolan; Karena McCarthy; Edward Eivers; Randy L Jirtle; Lucy Byrnes
Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish.
Development genes and evolution 2006;216(3):144-51.
2006: Jennifer R Weidman; Kristin A Maloney; Randy L Jirtle
Comparative phylogenetic analysis reveals multiple non-imprinted isoforms of opossum Dlk1.
Mammalian genome : official journal of the International Mammalian Genome Society 2006;17(2):157-67.
2006: Jennifer R Weidman; Dana C Dolinoy; Kristin A Maloney; Jan-Fang Cheng; Randy L Jirtle
Imprinting of opossum Igf2r in the absence of differential methylation and air.
Epigenetics : official journal of the DNA Methylation Society 2006;1(1):49-54.
2006: C K Hu; Shannon J McCall; John Madden; H Huang; Robert Clough; Randy L Jirtle; Mitchell S. Anscher
Loss of heterozygosity of M6P/IGF2R gene is an early event in the development of prostate cancer.
Prostate cancer and prostatic diseases 2006;9(1):62-7.
2005: Heather K Evans; Jennifer R Weidman; Dale O Cowley; Randy L Jirtle
Comparative phylogenetic analysis of blcap/nnat reveals eutherian-specific imprinted gene.
Molecular biology and evolution 2005;22(8):1740-8.
2005: Philippe P Luedi; Alexander J Hartemink; Randy L Jirtle
Genome-wide prediction of imprinted murine genes.
Genome research 2005;15(6):875-84.
2005: Susan Murphy; Brad A Freking; Timothy P L Smith; Kreg A Leymaster; Catherine M Nolan; Andrew A Wylie; Heather K Evans; Randy L Jirtle
Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep.
Mammalian genome : official journal of the International Mammalian Genome Society 2005;16(3):171-83.
2004: Jennifer R Weidman; Susan Murphy; Catherine M Nolan; Fred S Dietrich; Randy L Jirtle
Phylogenetic footprint analysis of IGF2 in extant mammals.
Genome research 2004;14(9):1726-32.
2004: Randy L Jirtle
IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer.
Gastroenterology 2004;126(4):1190-3.
2004: Robert A Waterland; Randy L Jirtle
Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases.
Nutrition (Burbank, Los Angeles County, Calif.) 2004;20(1):63-8.
2003: Robert A Waterland; Randy L Jirtle
Transposable elements: targets for early nutritional effects on epigenetic gene regulation.
Molecular and cellular biology 2003;23(15):5293-300.
2003: Mitchell S. Anscher; Lawrence Marks; Timothy D Shafman; Robert Clough; Hong Huang; Andrea Tisch; Michael T Munley; James E Herndon; Jennifer Garst; Jeffrey Crawford; Randy L Jirtle
Risk of long-term complications after TFG-beta1-guided very-high-dose thoracic radiotherapy.
International journal of radiation oncology, biology, physics 2003;56(4):988-95.
2003: Susan Murphy; Andrew A Wylie; Karen J Coveler; Philip D Cotter; Peter Papenhausen; V Reid Sutton; Lisa Shaffer; Randy L Jirtle
Epigenetic detection of human chromosome 14 uniparental disomy.
Human mutation 2003;22(1):92-7.
2003: Susan Murphy; Randy L Jirtle
Imprinting evolution and the price of silence.
BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25(6):577-88.
2003: Lisa G Dietz; Andrew A Wylie; K A Rauen; Susan Murphy; Randy L Jirtle; Philip D Cotter
Exclusion of maternal uniparental disomy of chromosome 14 in patients referred for Prader-Willi syndrome using a multiplex methylation polymerase chain reaction assay.
Journal of medical genetics 2003;40(4):e46.
2003: Timothy A Jamieson; David M. Brizel; J Keith Killian; Yoshihiko Oka; Hong-Seok Jang; Xiaolong Fu; Robert W Clough; Robin T Vollmer; Mitchell S. Anscher; Randy L Jirtle
M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis.
BMC cancer 2003;3():4.
2003: Andrew A Wylie; David J Pulford; Alison McVie-Wylie; Robert A Waterland; Heather K Evans; Yuan-Tsong Chen; Catherine M Nolan; Terry C Orton; Randy L Jirtle
Tissue-specific inactivation of murine M6P/IGF2R.
The American journal of pathology 2003;162(1):321-8.
2002: Brad A Freking; Susan Murphy; Andrew A Wylie; Simon J Rhodes; John W Keele; Kreg A Leymaster; Randy L Jirtle; Timothy P L Smith
Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.
Genome research 2002;12(10):1496-506.
2002: Yoshihiko Oka; Robert A Waterland; J Keith Killian; Catherine M Nolan; Hong-Seok Jang; Keiji Tohara; Seigo Sakaguchi; Tsuneyoshi Yao; Akinori Iwashita; Yutaka Yata; Terumi Takahara; Shin-Ichiro Sato; Kazuyuki Suzuki; Tomoyuki Masuda; Randy L Jirtle
M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan.
Hepatology (Baltimore, Md.) 2002;35(5):1153-63.
2002: Tao Li; Thanh H Vu; Kok-Onn Lee; Youwen Yang; Chuyen V Nguyen; Huy Q Bui; Zhi-Lan Zeng; Binh T Nguyen; Ji-Fan Hu; Susan Murphy; Randy L Jirtle; Andrew R Hoffman
An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.
The Journal of biological chemistry 2002;277(16):13518-27.
2001: Heather K Evans; Andrew A Wylie; Susan Murphy; Randy L Jirtle
The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2.
Genomics 2001;77(1-2):99-104.
2001: Mitchell S. Anscher; Lawrence Marks; Timothy D Shafman; Robert Clough; Hong Huang; Andrea Tisch; Michael T Munley; James E Herndon; Jennifer Garst; Jeffrey Crawford; Randy L Jirtle
Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(17):3758-65.
2001: J Keith Killian; Catherine M Nolan; Andrew A Wylie; T Li; T H Vu; A R Hoffman; Randy L Jirtle
Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary.
Human molecular genetics 2001;10(17):1721-8.
2001: J Keith Killian; Catherine M Nolan; N Stewart; BL Munday; Niels A Andersen; Stewart Nicol; Randy L Jirtle
Monotreme IGF2 expression and ancestral origin of genomic imprinting.
The Journal of experimental zoology 2001;291(2):205-12.
2001: Xiao-Long Fu; Hong Huang; Gunilla C Bentel; Robert Clough; Randy L Jirtle; Fengming P Kong; Lawrence Marks; Mitchell S. Anscher
Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta.
International journal of radiation oncology, biology, physics 2001;50(4):899-908.
2001: J Keith Killian; Thomas R Buckley; N Stewart; BL Munday; Randy L Jirtle
Marsupials and Eutherians reunited: genetic evidence for the Theria hypothesis of mammalian evolution.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(7):513-7.
2001: Catherine M Nolan; J Keith Killian; J N Petitte; Randy L Jirtle
Imprint status of M6P/IGF2R and IGF2 in chickens.
Development genes and evolution 2001;211(4):179-83.
2001: J Keith Killian; Yoshihiko Oka; Hong-Seok Jang; X Fu; Robert A Waterland; T Sohda; Seigo Sakaguchi; Randy L Jirtle
Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations.
Human mutation 2001;18(1):25-31.
2001: Fengming P Kong; Mitchell S. Anscher; Thomas A Sporn; M K Washington; Robert Clough; Mary Helen Barcellos-Hoff; Randy L Jirtle
Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury.
International journal of radiation oncology, biology, physics 2001;49(1):35-41.
2001: Susan Murphy; Andrew A Wylie; Randy L Jirtle
Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.
Genomics 2001;71(1):110-7.
2000: Andrew A Wylie; Susan Murphy; T C Orton; Randy L Jirtle
Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.
Genome research 2000;10(11):1711-8.
2000: J Keith Killian; John C Byrd; J V Jirtle; BL Munday; M K Stoskopf; Richard G MacDonald; Randy L Jirtle
M6P/IGF2R imprinting evolution in mammals.
Molecular cell 2000;5(4):707-16.
2000: Fengming P Kong; Mitchell S. Anscher; M K Washington; J Keith Killian; Randy L Jirtle
M6P/IGF2R is mutated in squamous cell carcinoma of the lung.
Oncogene 2000;19(12):1572-8.
2000: Randy L Jirtle; M Sander; J Carl Barrett
Genomic imprinting and environmental disease susceptibility.
Environmental health perspectives 2000;108(3):271-8.
2000: Susan Murphy; Randy L Jirtle
Imprinted genes as potential genetic and epigenetic toxicologic targets.
Environmental health perspectives 2000;108 Suppl 1():5-11.
1999: Fengming P Kong; Randy L Jirtle; D H Huang; Robert W Clough; Mitchell S. Anscher
Plasma transforming growth factor-beta1 level before radiotherapy correlates with long term outcome of patients with lung carcinoma.
Cancer 1999;86(9):1712-9.
1999: Gayathri Devi; AT De Souza; John C Byrd; Randy L Jirtle; Richard G MacDonald
Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers.
Cancer research 1999;59(17):4314-9.
1999: John C Byrd; Gayathri Devi; AT De Souza; Randy L Jirtle; Richard G MacDonald
Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations.
The Journal of biological chemistry 1999;274(34):24408-16.
1999: Randy L Jirtle
Genomic imprinting and cancer.
Experimental cell research 1999;248(1):18-24.
1999: JG Falls; David J Pulford; Andrew A Wylie; Randy L Jirtle
Genomic imprinting: implications for human disease.
The American journal of pathology 1999;154(3):635-47.
1999: J Keith Killian; Randy L Jirtle
Genomic structure of the human M6P/IGF2 receptor.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(1):74-7.
1999: David J Pulford; JG Falls; J Keith Killian; Randy L Jirtle
Polymorphisms, genomic imprinting and cancer susceptibility.
Mutation research 1999;436(1):59-67.
1998: Mitchell S. Anscher; Fengming P Kong; K Andrews; Robert Clough; Lawrence Marks; Gunilla C Bentel; Randy L Jirtle
Plasma transforming growth factor beta1 as a predictor of radiation pneumonitis.
International journal of radiation oncology, biology, physics 1998;41(5):1029-35.
1998: J J Mills; JG Falls; AT De Souza; Randy L Jirtle
Imprinted M6p/Igf2 receptor is mutated in rat liver tumors.
Oncogene 1998;16(21):2797-802.
1998: Mitchell S. Anscher; Fengming P Kong; Randy L Jirtle
The relevance of transforming growth factor beta 1 in pulmonary injury after radiation therapy.
Lung cancer (Amsterdam, Netherlands) 1998;19(2):109-20.
1997: Lawrence Marks; Michael T Munley; Gunilla C Bentel; Su-Min Zhou; Donna R Hollis; C Scarfone; Gregory S Sibley; Fengming P Kong; Randy L Jirtle; Ronald J Jaszczak; R Edward Coleman; V Tapson; Mitchell S. Anscher
Physical and biological predictors of changes in whole-lung function following thoracic irradiation.
International journal of radiation oncology, biology, physics 1997;39(3):563-70.
1997: Tomoya Yamada; AT De Souza; S Finkelstein; Randy L Jirtle
Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10351-5.
1997: Mitchell S. Anscher; Fengming P Kong; Lawrence Marks; Gunilla C Bentel; Randy L Jirtle
Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis.
International journal of radiation oncology, biology, physics 1997;37(2):253-8.
1997: AT De Souza; Tomoya Yamada; J J Mills; Randy L Jirtle
Imprinted genes in liver carcinogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(1):60-7.
1996: G R Hankins; AT De Souza; R C Bentley; M R Patel; Jeffrey R Marks; J Dirk Iglehart; Randy L Jirtle
M6P/IGF2 receptor: a candidate breast tumor suppressor gene.
Oncogene 1996;12(9):2003-9.
1996: J M Mansbach; J J Mills; I J Boyer; AT De Souza; G R Hankins; Randy L Jirtle
Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels.
Carcinogenesis 1996;17(1):171-4.
1995: AT De Souza; G R Hankins; M K Washington; T C Orton; Randy L Jirtle
M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.
Nature genetics 1995;11(4):447-9.
1995: Melvin Andersen; J J Mills; Randy L Jirtle; William F Greenlee
Negative selection in hepatic tumor promotion in relation to cancer risk assessment.
Toxicology 1995;102(1-2):223-37.
1995: S R Sue; Ravi Chari; Fengming P Kong; J J Mills; R L Fine; Randy L Jirtle; William C Meyers
Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma.
Annals of surgery 1995;222(2):171-8.
1995: Fengming P Kong; Mitchell S. Anscher; T Murase; B D Abbott; J Dirk Iglehart; Randy L Jirtle
Elevated plasma transforming growth factor-beta 1 levels in breast cancer patients decrease after surgical removal of the tumor.
Annals of surgery 1995;222(2):155-62.
1995: AT De Souza; G R Hankins; M K Washington; R L Fine; T C Orton; Randy L Jirtle
Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors.
Oncogene 1995;10(9):1725-9.
1995: J J Mills; Ravi Chari; I J Boyer; Michael N Gould; Randy L Jirtle
Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol.
Cancer research 1995;55(5):979-83.
1995: Randy L Jirtle
Liver tumor promotion: a process of natural selection.
Progress in clinical and biological research 1995;391():149-59.
1995: Ravi Chari; David T Price; S R Sue; William C Meyers; Randy L Jirtle
Down-regulation of transforming growth factor beta receptor type I, II, and III during liver regeneration.
American journal of surgery 1995;169(1):126-31; discussion 131-2.
1994: H Reisenbichler; Ravi Chari; I J Boyer; Randy L Jirtle
Transforming growth factor-beta receptors type I, II and III in phenobarbital-promoted rat liver tumors.
Carcinogenesis 1994;15(12):2763-7.
1994: Mitchell S. Anscher; T Murase; D M Prescott; Lawrence Marks; H Reisenbichler; Gunilla C Bentel; D Spencer; G Sherouse; Randy L Jirtle
Changes in plasma TGF beta levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis.
International journal of radiation oncology, biology, physics 1994;30(3):671-6.
1994: H Reisenbichler; Randy L Jirtle
BSA treatment of plasticware reduces TGF beta binding.
BioTechniques 1994;17(4):675-6.
1994: Randy L Jirtle; G R Hankins; H Reisenbichler; I J Boyer
Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital.
Carcinogenesis 1994;15(8):1473-8.
1994: L A Saperstein; Randy L Jirtle; M Farouk; H J Thompson; K S Chung; William C Meyers
Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat.
Hepatology (Baltimore, Md.) 1994;19(2):412-7.
1993: Randy L Jirtle; Jill D Haag; E A Ariazi; Michael N Gould
Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors.
Cancer research 1993;53(17):3849-52.
1993: Peter Eckl; L Anderson-Carnahan; Randy L Jirtle
Aquatic genotoxicity testing with rat hepatocytes in primary culture. I. SCE induction.
The Science of the total environment 1993;136(1-2):111-9.
1993: Mitchell S. Anscher; William P Peters; H Reisenbichler; William P Petros; Randy L Jirtle
Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer.
The New England journal of medicine 1993;328(22):1592-8.
1991: Randy L Jirtle; B I Carr; C D Scott
Modulation of insulin-like growth factor-II/mannose 6-phosphate receptors and transforming growth factor-beta 1 during liver regeneration.
The Journal of biological chemistry 1991;266(33):22444-50.
1991: Randy L Jirtle; S A Meyer
Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-beta 1 expression.
Digestive diseases and sciences 1991;36(5):659-68.
1991: Peter Eckl; T Alati; Randy L Jirtle
The effects of a purified diet on sister chromatid exchange frequencies and mitotic activity in adult rat hepatocytes.
Carcinogenesis 1991;12(4):643-6.
1991: J S Brockenbrough; S A Meyer; C X Li; Randy L Jirtle
Reversible and phorbol ester-specific defect of protein kinase C translocation in hepatocytes isolated from phenobarbital-treated rats.
Cancer research 1991;51(1):130-6.
1991: Randy L Jirtle; S A Meyer; J S Brockenbrough
Liver tumor promoter phenobarbital: a biphasic modulator of hepatocyte proliferation.
Progress in clinical and biological research 1991;369():209-16.
1990: Mitchell S. Anscher; I R Crocker; Randy L Jirtle
Transforming growth factor-beta 1 expression in irradiated liver.
Radiation research 1990;122(1):77-85.
1989: S A Meyer; T A Gibbs; Randy L Jirtle
Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes.
Cancer research 1989;49(21):5907-12.
1989: T Alati; Peter Eckl; Randy L Jirtle
An in vitro micronucleus assay for determining the radiosensitivity of hepatocytes.
Radiation research 1989;119(3):562-8.
1989: T Alati; M Van Cleeff; Randy L Jirtle
Radiosensitivity of parenchymal hepatocytes as a function of oxygen concentration.
Radiation research 1989;118(3):488-501.
1989: S A Meyer; Randy L Jirtle
Phenobarbital decreases hepatocyte EGF receptor expression independent of protein kinase C activation.
Biochemical and biophysical research communications 1989;158(3):652-9.
1988: T Alati; M Van Cleeff; S C Strom; Randy L Jirtle
Radiation sensitivity of adult human parenchymal hepatocytes.
Radiation research 1988;115(1):152-60.
1988: Peter Eckl; S A Meyer; W R Whitcombe; Randy L Jirtle
Phenobarbital reduces EGF receptors and the ability of physiological concentrations of calcium to suppress hepatocyte proliferation.
Carcinogenesis 1988;9(3):479-83.
1987: Peter Eckl; W R Whitcomb; G Michalopoulos; Randy L Jirtle
Effects of EGF and calcium on adult parenchymal hepatocyte proliferation.
Journal of cellular physiology 1987;132(2):363-6.
1987: Peter Eckl; S C Strom; G Michalopoulos; Randy L Jirtle
Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly and indirectly acting mutagens/carcinogens.
Carcinogenesis 1987;8(8):1077-83.
1987: George K Michalopoulos; Peter Eckl; J L Cruise; D L Novicki; Randy L Jirtle
Mechanisms of rodent liver carcinogenesis.
Toxicology and industrial health 1987;3(2):119-28.