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Hakryul Jo

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Chemicals & Drugs

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Hakryul Jo; Qingming Hou; Hengye Man; Subhanjan Mondal; Eiichiro Nagata; Amit Prasad; Alan C Rigby; Kumaran Shanmugasundaram; Alok K Sharma; Shunya Takizawa; Dewar Tan; Alexander O Tejeda; Joe K Tung; Hongbo R Luo
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
Hakryul Jo; Hongbo R Luo
Exploiting effectors of Rac GTPase.
Hakryul Jo; Pang-Kuo Lo; Yitang Li; Fabien Loison; Sarah Green; Jake Wang; Leslie E Silberstein; Keqiang Ye; Hexin Chen; Hongbo R Luo
Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.

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All Publications

2012: Hakryul Jo; Qingming Hou; Hengye Man; Subhanjan Mondal; Eiichiro Nagata; Amit Prasad; Alan C Rigby; Kumaran Shanmugasundaram; Alok K Sharma; Shunya Takizawa; Dewar Tan; Alexander O Tejeda; Joe K Tung; Hongbo R Luo
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10581-6.
2012: Hakryul Jo; Hongbo R Luo
Exploiting effectors of Rac GTPase.
Chemistry & biology 2012;19(2):169-71.
2011: Hakryul Jo; Pang-Kuo Lo; Yitang Li; Fabien Loison; Sarah Green; Jake Wang; Leslie E Silberstein; Keqiang Ye; Hexin Chen; Hongbo R Luo
Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(16):6486-91.
2010: Hidenori Hattori; Kulandayan K Subramanian; Jiro Sakai; Yonghui Jia; Yitang Li; Timothy F Porter; Fabien Loison; Bara Sarraj; Anongnard Kasorn; Hakryul Jo; Catlyn Blanchard; Dorothy Zirkle; Douglas McDonald; Sung-Yun Pai; Charles N Serhan; Hongbo R Luo
Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3546-51.
2010: Hakryul Jo; Fabien Loison; Hidenori Hattori; Leslie E Silberstein; Hongtao Yu; Hongbo R Luo
Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs.
PloS one 2010;5(4):e10318.
2008: Hakryul Jo; Yonghui Jia; Kulandayan K Subramanian; Hidenori Hattori; Hongbo R Luo
Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation.
Molecular and cellular biology 2008;28(13):4285-99.
2007: Yonghui Jia; Kulandayan K Subramanian; Christophe Erneux; Valérie Pouillon; Hidenori Hattori; Hakryul Jo; Jian You; Daocheng Zhu; Stéphane Schurmans; Hongbo R Luo
Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils.
Immunity 2007;27(3):453-67.
2007: Hidenori Hattori; Xueqing Zhang; Yonghui Jia; Kulandayan K Subramanian; Hakryul Jo; Fabien Loison; Peter E Newburger; Hongbo R Luo
RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells.
Blood 2007;110(2):640-50.
2007: Kulandayan K Subramanian; Yonghui Jia; Daocheng Zhu; Benjamin T Simms; Hakryul Jo; Hidenori Hattori; Jian You; Joseph P Mizgerd; Hongbo R Luo
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions.
Blood 2007;109(9):4028-37.
2006: Daocheng Zhu; Hidenori Hattori; Hakryul Jo; Yonghui Jia; Kulandayan K Subramanian; Fabien Loison; Jian You; Yi Le; Marek Honczarenko; Leslie E Silberstein; Hongbo R Luo
Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14836-41.
2003: Sonya M Khersonsky; Da-Woon Jung; Tae-Wook Kang; Daniel P Walsh; Ho-Sang Moon; Hakryul Jo; Eric M Jacobson; Vivekananda Shetty; Thomas A Neubert; Young-Tae Chang
Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening.
Journal of the American Chemical Society 2003;125(39):11804-5.
2003: Jarema Malicki; Hakryul Jo; Zac Pujic
Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning.
Developmental biology 2003;259(1):95-108.
2002: Jarema Malicki; Hakryul Jo; Xiangyun Wei; Monica Hsiung; Zac Pujic
Analysis of gene function in the zebrafish retina.
Methods (San Diego, Calif.) 2002;28(4):427-38.