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Phillip Jobe

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Michelle A Merrill; Richard W Clough; John W Dailey; Phillip C Jobe; Ronald A Browning
Localization of the serotonergic terminal fields modulating seizures in the genetically epilepsy-prone rat.
Phillip C Jobe; Ronald A Browning
The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant.
Michelle A Merrill; Richard W Clough; Phillip C Jobe; Ronald A Browning
Brainstem seizure severity regulates forebrain seizure expression in the audiogenic kindling model.

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All Publications

2007: Michelle A Merrill; Richard W Clough; John W Dailey; Phillip C Jobe; Ronald A Browning
Localization of the serotonergic terminal fields modulating seizures in the genetically epilepsy-prone rat.
Epilepsy research 2007;76(2-3):93-102.
2005: Phillip C Jobe; Ronald A Browning
The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant.
Epilepsy & behavior : E&B 2005;7(4):602-19.
2005: Michelle A Merrill; Richard W Clough; Phillip C Jobe; Ronald A Browning
Brainstem seizure severity regulates forebrain seizure expression in the audiogenic kindling model.
Epilepsia 2005;46(9):1380-8.
2005: M F D Moraes; Pankaj Mishra; Phillip C Jobe; Norberto Garcia-Cairasco
An electrographic analysis of the synchronous discharge patterns of GEPR-9s generalized seizures.
Brain research 2005;1046(1-2):1-9.
2005: M F D Moraes; M Chavali; Pankaj Mishra; Phillip C Jobe; Norberto Garcia-Cairasco
A comprehensive electrographic and behavioral analysis of generalized tonic-clonic seizures of GEPR-9s.
Brain research 2005;1033(1):1-12.
2004: Phillip C Jobe
Affective disorder and epilepsy comorbidity: implications for development of treatments, preventions and diagnostic approaches.
Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS) 2004;35(1):53-68.
2004: Phillip C Jobe
Shared mechanisms of antidepressant and antiepileptic treatments: drugs and devices.
Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS) 2004;35(1):25-37.
2004: JB Eells; Richard W Clough; Ronald A Browning; Phillip C Jobe
Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats.
Neuroscience 2004;123(1):279-92.
2003: Phillip C Jobe
Common pathogenic mechanisms between depression and epilepsy: an experimental perspective.
Epilepsy & behavior : E&B 2003;4 Suppl 3():S14-24.
2003: Michelle A Merrill; Richard W Clough; Phillip C Jobe; Ronald A Browning
Role of the superior colliculus and the intercollicular nucleus in the brainstem seizure circuitry of the genetically epilepsy-prone rat.
Epilepsia 2003;44(3):305-14.
2002: Phillip C Jobe
Are there specific anatomical and/or transmitter systems (cortical or subcortical) that should be targeted?
International review of neurobiology 2002;49():221-52.
2001: B S Kurtz; J Lehman; P Garlick; J Amberg; Pankaj Mishra; John W Dailey; R Weber; Phillip C Jobe
Penetrance and expressivity of genes involved in the development of epilepsy in the genetically epilepsy-prone rat (GEPR).
Journal of neurogenetics 2001;15(3-4):233-44.
2000: Jae Ryun Ryu; Chang Yell Shin; K H Park; G S Jeon; H Kim; W Kim; John W Dailey; Phillip C Jobe; S S Cho; Kwang Ho Ko
Effect of repeated seizure experiences on tyrosine hydroxylase immunoreactivities in the brain of genetically epilepsy-prone rats.
Brain research bulletin 2000;53(6):777-82.
2000: JB Eells; Richard W Clough; J W Miller; Phillip C Jobe; Ronald A Browning
Fos expression and 2-deoxyglucose uptake following seizures in developing genetically epilepsy-prone rats.
Brain research bulletin 2000;52(5):379-89.
2000: James F. Graumlich; Richard G McLaughlin; D Birkhahn; N Shah; A Burk; Phillip C Jobe; John W Dailey
Subcutaneous microdialysis in rats correlates with carbamazepine concentrations in plasma and brain.
Epilepsy research 2000;40(1):25-32.
2000: Dong Ook Seo; Chang Yell Shin; Jae Ryun Ryu; Jae Hoon Cheong; Chang-Rak Choi; John W Dailey; Maarten E A Reith; Phillip C Jobe; Kwang Ho Ko
Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats.
European journal of pharmacology 2000;396(2-3):53-8.
1999: James F. Graumlich; Richard G McLaughlin; D Birkhahn; N Shah; A Burk; Phillip C Jobe; John W Dailey
Carbamazepine pharmacokinetics-pharmacodynamics in genetically epilepsy-prone rats.
European journal of pharmacology 1999;369(3):305-11.
1999: Jae Ryun Ryu; Phillip C Jobe; Joseph C. Milbrandt; Pankaj Mishra; Richard W Clough; Ronald A Browning; John W Dailey; Dong Ook Seo; Kwang Ho Ko
Morphological deficits in noradrenergic neurons in GEPR-9s stem from abnormalities in both the locus coeruleus and its target tissues.
Experimental neurology 1999;156(1):84-91.
1999: Ronald A Browning; Chunhe Wang; Daniel Nelson; Phillip C Jobe
Effect of precollicular transection on audiogenic seizures in genetically epilepsy-prone rats.
Experimental neurology 1999;155(2):295-301.
1999: Dong Ook Seo; Chang Yell Shin; C J Lee; John W Dailey; Maarten E A Reith; Phillip C Jobe; Kwang Ho Ko
Effect of alterations in extracellular norepinephrine on adrenoceptors: a microdialysis study in freely moving rats.
European journal of pharmacology 1999;365(1):39-46.
1999: Phillip C Jobe; John W Dailey; J F Wernicke
A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders.
Critical reviews in neurobiology 1999;13(4):317-56.
1998: Qing-Shan Yan; Maarten E A Reith; S G Yan; Phillip C Jobe
Effect of systemic ethanol on basal and stimulated glutamate releases in the nucleus accumbens of freely moving Sprague-Dawley rats: a microdialysis study.
Neuroscience letters 1998;258(1):29-32.
1998: John W Dailey; Maarten E A Reith; K R Steidley; Joseph C. Milbrandt; Phillip C Jobe
Carbamazepine-induced release of serotonin from rat hippocampus in vitro.
Epilepsia 1998;39(10):1054-63.
1998: Qing-Shan Yan; John W Dailey; J L Steenbergen; Phillip C Jobe
Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.
Brain research 1998;780(2):199-209.
1998: Richard W Clough; B R Peterson; J L Steenbergen; Phillip C Jobe; JB Eells; Ronald A Browning; Pankaj Mishra
Neurite extension of developing noradrenergic neurons is impaired in genetically epilepsy-prone rats (GEPR-3s): an in vitro study on the locus coeruleus.
Epilepsy research 1998;29(2):135-46.
1997: Ronald A Browning; A V Wood; Michelle A Merrill; John W Dailey; Phillip C Jobe
Enhancement of the anticonvulsant effect of fluoxetine following blockade of 5-HT1A receptors.
European journal of pharmacology 1997;336(1):1-6.
1997: JB Eells; Richard W Clough; Ronald A Browning; Phillip C Jobe
Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models.
Neuroscience letters 1997;233(1):21-4.
1997: Qing-Shan Yan; Maarten E A Reith; Phillip C Jobe; John W Dailey
Dizocilpine (MK-801) increases not only dopamine but also serotonin and norepinephrine transmissions in the nucleus accumbens as measured by microdialysis in freely moving rats.
Brain research 1997;765(1):149-58.
1997: Elaine Aparecida Del Bel; P R Oliveira; J A C Oliveira; P K Mishra; Phillip C Jobe; Norberto Garcia-Cairasco
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1997;30(8):971-9.
1997: Richard W Clough; JB Eells; Ronald A Browning; Phillip C Jobe
Seizures and proto-oncogene expression of fos in the brain of adult genetically epilepsy-prone rats.
Experimental neurology 1997;146(2):341-53.
1997: John W Dailey; Maarten E A Reith; Qing-Shan Yan; MY Li; Phillip C Jobe
Carbamazepine increases extracellular serotonin concentration: lack of antagonism by tetrodotoxin or zero Ca2+.
European journal of pharmacology 1997;328(2-3):153-62.
1997: John W Dailey; Maarten E A Reith; Qing-Shan Yan; MY Li; Phillip C Jobe
Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships.
Neuroscience letters 1997;227(1):13-6.
1996: Richard W Clough; M Statnick; M Maring-Smith; C Wang; JB Eells; Ronald A Browning; J Dailey; Phillip C Jobe
Fetal raphe transplants reduce seizure severity in serotonin-depleted GEPRs.
Neuroreport 1996;8(1):341-6.
1996: Qing-Shan Yan; Maarten E A Reith; Phillip C Jobe; John W Dailey
Focal ethanol elevates extracellular dopamine and serotonin concentrations in the rat ventral tegmental area.
European journal of pharmacology 1996;301(1-3):49-57.
1996: M A Statnick; John W Dailey; Phillip C Jobe; Ronald A Browning
Abnormalities in brain serotonin concentration, high-affinity uptake, and tryptophan hydroxylase activity in severe-seizure genetically epilepsy-prone rats.
Epilepsia 1996;37(4):311-21.
1996: M Statnick; J Dailey; Phillip C Jobe; Ronald A Browning
Neither intranigral fluoxetine nor 5,7-dihydroxytryptamine alter audiogenic seizures in genetically epilepsy-prone rats.
European journal of pharmacology 1996;299(1-3):93-102.
1996: L L Coffey; Maarten E A Reith; NH Chen; P K Mishra; Phillip C Jobe
Amygdala kindling of forebrain seizures and the occurrence of brainstem seizures in genetically epilepsy-prone rats.
Epilepsia 1996;37(2):188-97.
1996: M A Statnick; M L Maring-Smith; Richard W Clough; C Wang; John W Dailey; Phillip C Jobe; Ronald A Browning
Effect of 5,7-dihydroxytryptamine on audiogenic seizures in genetically epilepsy-prone rats.
Life sciences 1996;59(21):1763-71.
1996: M A Statnick; John W Dailey; Phillip C Jobe; Ronald A Browning
Abnormalities in 5-HT1A and 5-HT1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s).
Neuropharmacology 1996;35(1):111-8.
1996: John W Dailey; Qing-Shan Yan; L E Adams-Curtis; Jae Ryun Ryu; K H Ko; Pankaj Mishra; Phillip C Jobe
Neurochemical correlates of antiepileptic drugs in the genetically epilepsy-prone rat (GEPR).
Life sciences 1996;58(4):259-66.
1995: John W Dailey; J H Cheong; K H Ko; L E Adams-Curtis; Phillip C Jobe
Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response.
Neuroscience letters 1995;195(2):77-80.
1995: Qing-Shan Yan; Phillip C Jobe; John W Dailey
Further evidence of anticonvulsant role for 5-hydroxytryptamine in genetically epilepsy-prone rats.
British journal of pharmacology 1995;115(7):1314-8.
1995: Phillip C Jobe; Pankaj Mishra; L E Adams-Curtis; V U Deoskar; K H Ko; Ronald A Browning; John W Dailey
The genetically epilepsy-prone rat (GEPR).
Italian journal of neurological sciences 1995;16(1-2):91-9.
1994: John W Dailey; Dong Ook Seo; Qing-Shan Yan; K H Ko; M Jo; Phillip C Jobe
The anticonvulsant effect of the broad spectrum anticonvulsant loreclezole may be mediated in part by serotonin in rats: a microdialysis study.
Neuroscience letters 1994;178(2):179-83.
1994: NH Chen; C Wang; Phillip C Jobe; Maarten E A Reith
Facilitation of amygdala kindling development and kindled seizures by metaphit.
Epilepsia 1994;35(5):927-32.
1994: Qing-Shan Yan; Phillip C Jobe; J H Cheong; K H Ko; John W Dailey
Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats.
Naunyn-Schmiedeberg's archives of pharmacology 1994;350(2):149-52.
1994: Phillip C Jobe; L E Adams-Curtis; T F Burks; R W Fuller; C C Peck; R R Ruffolo; O C Snead; R L Woosley
The essential role of integrative biomedical sciences in protecting and contributing to the health and well-being of our nation.
The Physiologist 1994;37(3):79-86.
1994: C Wang; Pankaj Mishra; John W Dailey; Phillip C Jobe; Ronald A Browning
Noradrenergic terminal fields as determinants of seizure predisposition in GEPR-3s: a neuroanatomic assessment with intracerebral microinjections of 6-hydroxydopamine.
Epilepsy research 1994;18(1):1-9.
1994: M C Doretto; R L Burger; Pankaj Mishra; Norberto Garcia-Cairasco; John W Dailey; Phillip C Jobe
A microdialysis study of amino acid concentrations in the extracellular fluid of the substantia nigra of freely behaving GEPR-9s: relationship to seizure predisposition.
Epilepsy research 1994;17(2):157-65.
1994: Qing-Shan Yan; Phillip C Jobe; John W Dailey
Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats.
European journal of pharmacology 1994;252(1):105-12.
1994: Pankaj Mishra; R L Burger; A F Bettendorf; Ronald A Browning; Phillip C Jobe
Role of norepinephrine in forebrain and brainstem seizures: chemical lesioning of locus ceruleus with DSP4.
Experimental neurology 1994;125(1):58-64.
1994: Phillip C Jobe; Pankaj Mishra; Ronald A Browning; C Wang; L E Adams-Curtis; K H Ko; John W Dailey
Noradrenergic abnormalities in the genetically epilepsy-prone rat.
Brain research bulletin 1994;35(5-6):493-504.
1994: Richard W Clough; Ronald A Browning; M L Maring; M A Statnick; C Wang; Phillip C Jobe
Effects of intraventricular locus coeruleus transplants on seizure severity in genetically epilepsy-prone rats following depletion of brain norepinephrine.
Journal of neural transplantation & plasticity 1994;5(1):65-79.
1993: Qing-Shan Yan; Phillip C Jobe; John W Dailey
Noradrenergic mechanisms for the anticonvulsant effects of desipramine and yohimbine in genetically epilepsy-prone rats: studies with microdialysis.
Brain research 1993;610(1):24-31.
1993: Qing-Shan Yan; Phillip C Jobe; John W Dailey
Thalamic deficiency in norepinephrine release detected via intracerebral microdialysis: a synaptic determinant of seizure predisposition in the genetically epilepsy-prone rat.
Epilepsy research 1993;14(3):229-36.
1993: Pankaj Mishra; E H Kahle; A F Bettendorf; John W Dailey; Phillip C Jobe
Anticonvulsant effects of intracerebroventricularly administered norepinephrine are potentiated in the presence of monoamine oxidase inhibition in severe seizure genetically epilepsy-prone rats (GEPR-9s).
Life sciences 1993;52(17):1435-41.
1992: N Ludvig; Pankaj Mishra; Qing-Shan Yan; Stephen Michael Lasley; R L Burger; Phillip C Jobe
The paradoxical effect of NMDA receptor stimulation on electrical activity of the sensorimotor cortex in freely behaving rats: analysis by combined EEG-intracerebral microdialysis.
Synapse (New York, N.Y.) 1992;12(2):87-98.
1992: N Ludvig; Pankaj Mishra; Phillip C Jobe
Dibutyryl cyclic AMP has epileptogenic potential in the hippocampus of freely behaving rats: a combined EEG-intracerebral microdialysis study.
Neuroscience letters 1992;141(2):187-91.
1992: N Ludvig; Pankaj Mishra; Qing-Shan Yan; Stephen Michael Lasley; R L Burger; Phillip C Jobe
The combined EEG-intracerebral microdialysis technique: a new tool for neuropharmacological studies on freely behaving animals.
Journal of neuroscience methods 1992;43(2-3):129-37.
1992: Qing-Shan Yan; Pankaj Mishra; R L Burger; A F Bettendorf; Phillip C Jobe; John W Dailey
Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats.
The Journal of pharmacology and experimental therapeutics 1992;261(2):652-9.
1992: John W Dailey; Qing-Shan Yan; Pankaj Mishra; R L Burger; Phillip C Jobe
Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats.
The Journal of pharmacology and experimental therapeutics 1992;260(2):533-40.
1992: John W Dailey; Pankaj Mishra; K H Ko; J E Penny; Phillip C Jobe
Serotonergic abnormalities in the central nervous system of seizure-naive genetically epilepsy-prone rats.
Life sciences 1992;50(4):319-26.
1991: Richard W Clough; Ronald A Browning; M L Maring; Phillip C Jobe
Intracerebral grafting of fetal dorsal pons in genetically epilepsy-prone rats: effects on audiogenic-induced seizures.
Experimental neurology 1991;112(2):195-9.
1991: John W Dailey; Pankaj Mishra; K H Ko; J E Penny; Phillip C Jobe
Noradrenergic abnormalities in the central nervous system of seizure-naive genetically epilepsy-prone rats.
Epilepsia 1991;32(2):168-73.
1991: John W Dailey; Stephen Michael Lasley; R L Burger; A F Bettendorf; Pankaj Mishra; Phillip C Jobe
Amino acids, monoamines and audiogenic seizures in genetically epilepsy-prone rats: effects of aspartame.
Epilepsy research 1991;8(2):122-33.
1991: Phillip C Jobe; Pankaj Mishra; N Ludvig; John W Dailey
Scope and contribution of genetic models to an understanding of the epilepsies.
Critical reviews in neurobiology 1991;6(3):183-220.
1991: N Ludvig; V Burmeister; Phillip C Jobe; R L Kincaid
Electron microscopic immunocytochemical evidence that the calmodulin-dependent cyclic nucleotide phosphodiesterase is localized predominantly at postsynaptic sites in the rat brain.
Neuroscience 1991;44(2):491-500.
1990: Ronald A Browning; C Wang; M L Lanker; Phillip C Jobe
Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and pattern.
Epilepsy research 1990;6(1):1-11.
1990: S A Mills; S Razani-Boroujerdi; C E Reigel; Phillip C Jobe; D D Savage
Decrease in hippocampal [3H]vinylidene kainic acid binding in genetically epilepsy-prone rats.
Neuroscience 1990;35(3):519-24.
1989: C E Reigel; Phillip C Jobe; John W Dailey; D D Savage
Ontogeny of sound-induced seizures in the genetically epilepsy-prone rat.
Epilepsy research 1989;4(1):63-71.
1989: Pankaj Mishra; John W Dailey; C E Reigel; Phillip C Jobe
Audiogenic convulsions in moderate seizure genetically epilepsy-prone rats (GEPR-3s).
Epilepsy research 1989;3(3):191-8.
1989: John W Dailey; Stephen Michael Lasley; Pankaj Mishra; A F Bettendorf; R L Burger; Phillip C Jobe
Aspartame fails to facilitate pentylenetetrazol-induced convulsions in CD-1 mice.
Toxicology and applied pharmacology 1989;98(3):475-86.
1989: Ronald A Browning; D R Wade; M Marcinczyk; G L Long; Phillip C Jobe
Regional brain abnormalities in norepinephrine uptake and dopamine beta-hydroxylase activity in the genetically epilepsy-prone rat.
The Journal of pharmacology and experimental therapeutics 1989;249(1):229-35.
1989: John W Dailey; C E Reigel; Pankaj Mishra; Phillip C Jobe
Neurobiology of seizure predisposition in the genetically epilepsy-prone rat.
Epilepsy research 1989;3(1):3-17.
1988: Pankaj Mishra; John W Dailey; C E Reigel; M L Tomsic; Phillip C Jobe
Sex-specific distinctions in audiogenic convulsions exhibited by severe seizure genetically epilepsy-prone rats (GEPR-9s).
Epilepsy research 1988;2(5):309-16.
1988: C E Reigel; Phillip C Jobe; John W Dailey; J J Stewart
Responsiveness of genetically epilepsy-prone rats to intracerebroventricular morphine-induced convulsions.
Life sciences 1988;42(18):1743-9.
1988: Pankaj Mishra; John W Dailey; C E Reigel; Phillip C Jobe
Brain norepinephrine and convulsions in the genetically epilepsy-prone rat: sex-dependent responses to Ro 4-1284 treatment.
Life sciences 1988;42(11):1131-7.
1988: D D Savage; S A Mills; Phillip C Jobe; C E Reigel
Elevation of naloxone-sensitive 3H-dihydromorphine binding in hippocampal formation of genetically epilepsy-prone rats.
Life sciences 1988;43(3):239-46.
1986: D D Savage; C E Reigel; Phillip C Jobe
The development of kindled seizures is accelerated in the genetically epilepsy-prone rat.
Life sciences 1986;39(10):879-86.
1986: Phillip C Jobe; John W Dailey; C E Reigel
Noradrenergic and serotonergic determinants of seizure susceptibility and severity in genetically epilepsy-prone rats.
Life sciences 1986;39(9):775-82.
1986: C E Reigel; John W Dailey; Phillip C Jobe
The genetically epilepsy-prone rat: an overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs.
Life sciences 1986;39(9):763-74.
1986: D D Savage; C E Reigel; Phillip C Jobe
Angular bundle kindling is accelerated in rats with a genetic predisposition to acoustic stimulus-induced seizures.
Brain research 1986;376(2):412-5.
1985: Ronald A Browning; Daniel Nelson; N Mogharreban; Phillip C Jobe; H E Laird
Effect of midbrain and pontine tegmental lesions on audiogenic seizures in genetically epilepsy-prone rats.
Epilepsia 1985;26(2):175-83.