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Jesper Johannesen

Research Profile

Disorders

Type 1 Diabetes Mellitus

Geographic Areas

Denmark

Concepts & Ideas

Chemicals & Drugs

Anatomy

Islets of Langerhans

Physiology

Living Beings

Rats

Procedures

Polymerase Chain Reaction

Genes & Molecular Sequences

Phenomena

Polymorphism, Single-Stranded Conformational

Co-author Network

Publications

TOP 3
S Fredheim; B Hertz; Jesper Johannesen; A Johansen; M H Lauridsen; L Lyngsøe; H B Mortensen; B Olsen; H Rida; J Svensson; M L M Andersen; Niels H Birkebaek
Diabetic ketoacidosis at the onset of type 1 diabetes is associated with future HbA1c levels.
Jannet Svensson; Åke Lernmark; Bendix Carstensen; Stefanie Eising; David Michael Hougaard; Jesper Johannesen; Henrik Bindesbøl Mortensen; Anita Nilsson; Flemming Pociot; Lars Bjarke Simonsen; Kristin Skogstrand
Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings.
Jesper Johannesen; Jannet Svensson; Regine Bergholdt; Stefanie Eising; Hanne Gramstrup; Erik Frandsen; Jens Dick-Nielsen; Lars Hansen; Flemming Pociot; Henrik B Mortensen
Hypoglycemia, S-ACE and ACE genotypes in a Danish nationwide population of children and adolescents with type 1 diabetes.

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All Publications

2013: S Fredheim; B Hertz; Jesper Johannesen; A Johansen; M H Lauridsen; L Lyngsøe; H B Mortensen; B Olsen; H Rida; J Svensson; M L M Andersen; Niels H Birkebaek
Diabetic ketoacidosis at the onset of type 1 diabetes is associated with future HbA1c levels.
Diabetologia 2013;56(5):995-1003.
2012: Jannet Svensson; Åke Lernmark; Bendix Carstensen; Stefanie Eising; David Michael Hougaard; Jesper Johannesen; Henrik Bindesbøl Mortensen; Anita Nilsson; Flemming Pociot; Lars Bjarke Simonsen; Kristin Skogstrand
Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings.
Human immunology 2012;73(11):1116-26.
2011: Jesper Johannesen; Jannet Svensson; Regine Bergholdt; Stefanie Eising; Hanne Gramstrup; Erik Frandsen; Jens Dick-Nielsen; Lars Hansen; Flemming Pociot; Henrik B Mortensen
Hypoglycemia, S-ACE and ACE genotypes in a Danish nationwide population of children and adolescents with type 1 diabetes.
Pediatric diabetes 2011;12(2):100-6.
2008: Jesper Johannesen; Stefanie Eising; Susanne Kohlwes; Susanne Riis; Maiken Beck; Bendix Carstensen; Inger Bendtson; Jørn Nerup
Treatment of Danish adolescent diabetic patients with CSII - a matched study to MDI.
Pediatric diabetes 2008;9(1):23-8.
2006: Allan E Karlsen; Zenia M Størling; Thomas Sparre; Martin R Larsen; Amer Mahmood; Joachim Størling; Peter Roepstorff; Krzysztof Wrzesinski; Peter Mose Larsen; Stephen Fey; Karin Nielsen; Peter E Heding; Camillo Ricordi; Jesper Johannesen; Ole P Kristiansen; Ulla Bjerre Christensen; Ingrid Kockum; Holger Luthman; Jørn Nerup; Flemming Pociot
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.
Biochemical and biophysical research communications 2006;344(1):406-15.
2004: Jesper Johannesen; Angeles Pie; Allan E Karlsen; Zenia Marian Larsen; Allan Jensen; Henrik Vissing; Ole P Kristiansen; Flemming Pociot; Jørn Nerup
Is mortalin a candidate gene for T1DM ?
Autoimmunity 2004;37(6-7):423-30.
2004: Ole P Kristiansen; Allan E Karlsen; Zenia Marian Larsen; Jesper Johannesen; Flemming Pociot; Thomas Mandrup-Poulsen
Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity.
Scandinavian journal of immunology 2004;59(6):582-91.
2004: Regine Bergholdt; Pegah Ghandil; Jesper Johannesen; Ole P Kristiansen; Ingrid Kockum; H Luthman; Kjersti S Rønningen; Jørn Nerup; Cécile Julier; Flemming Pociot
Genetic and functional evaluation of an interleukin-12 polymorphism (IDDM18) in families with type 1 diabetes.
Journal of medical genetics 2004;41(4):e39.
2004: Zenia Marian Larsen; Jesper Johannesen; Ole P Kristiansen; Jørn Nerup; Flemming Pociot
Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(3):218-22.
2003: Ole P Kristiansen; Runa Louise Nolsoe; Lykke Larsen; Anette M P Gjesing; Jesper Johannesen; Zenia Marian Larsen; Anne E Lykkesfeldt; Allan E Karlsen; Flemming Pociot; Thomas Mandrup-Poulsen
Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females.
Human molecular genetics 2003;12(10):1101-10.
2003: Jesper Johannesen; Allan E Karlsen; Flemming Pociot; Sif G Roenn; Jørn Nerup
Strain dependent rat iNOS promoter activity--correlation to identified WT1 transcription factor binding site.
Autoimmunity 2003;36(3):167-75.
2002: Runa Louise Nolsoe; Ole P Kristiansen; Zenia Marian Larsen; Jesper Johannesen; Flemming Pociot; Thomas Mandrup-Poulsen
Complete mutation scan of the human Fas ligand gene: linkage studies in Type I diabetes mellitus families.
Diabetologia 2002;45(1):134-9.
2001: Allan E Karlsen; Sif G Rønn; Karen Lindberg; Jesper Johannesen; Elisabeth D Galsgaard; Flemming Pociot; Jens H Nielsen; Thomas Mandrup-Poulsen; Jørn Nerup; Nils Billestrup
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12191-6.
2001: Jesper Johannesen; Flemming Pociot; Allan E Karlsen; Thomas Mandrup-Poulsen; Jørn Nerup
Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression.
European cytokine network 2001;12(3):501-9.
2001: Jesper Johannesen; A Pie; Flemming Pociot; Ole P Kristiansen; Allan E Karlsen; Jørn Nerup
Linkage of the human inducible nitric oxide synthase gene to type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(6):2792-6.
2000: Regine Bergholdt; Zenia Marian Larsen; NA Andersen; Jesper Johannesen; Ole P Kristiansen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level.
Genes and immunity 2000;1(8):495-500.
2000: Ole P Kristiansen; Runa Louise Nolsoe; H Holst; Sine Reker Hadrup; Zenia Marian Larsen; Jesper Johannesen; Jørn Nerup; Flemming Pociot; Thomas Mandrup-Poulsen
The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes.
Immunogenetics 2000;52(1-2):107-11.
2000: Jesper Johannesen; Flemming Pociot; Ole P Kristiansen; Allan E Karlsen; Jørn Nerup
No evidence for linkage in the promoter region of the inducible nitric oxide synthase gene (NOS2) in a Danish type 1 diabetes population.
Genes and immunity 2000;1(6):362-6.
2000: Runa Louise Nolsoe; Ole P Kristiansen; K Sangthongpitag; Zenia Marian Larsen; Jesper Johannesen; Allan E Karlsen; Flemming Pociot; Jørn Nerup; CF Verge; Thomas Mandrup-Poulsen
Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with type I diabetes mellitus. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Diabetologia 2000;43(6):800-8.
2000: Ole P Kristiansen; Flemming Pociot; E P Bennett; H Clausen; Jesper Johannesen; Jørn Nerup; Thomas Mandrup-Poulsen
IDDM7 links to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Human mutation 2000;15(3):295-6.
2000: Ole P Kristiansen; Flemming Pociot; Jesper Johannesen; Regine Bergholdt; C A Dinarello; Jørn Nerup; Thomas Mandrup-Poulsen
Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus.
Cytokine 2000;12(2):171-5.
1999: T Lorenzen; Flemming Pociot; Jesper Johannesen; Ole P Kristiansen; Jørn Nerup
A population-based survey of frequencies of self-reported spontaneous and induced abortions in Danish women with Type 1 diabetes mellitus. Danish IDDM Epidemiology and Genetics Group.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(6):472-6.
1999: T Lorenzen; Flemming Pociot; L S Stilgren; Ole P Kristiansen; Jesper Johannesen; P B Olsen; A Walmar; A V Larsen; N C Albrechtsen; P C Eskildsen; O O Andersen; J Nerup
[Markers for risk of IDDM in children of Danish patients with IDDM. A population-based, historical prospective study].
Ugeskrift for laeger 1999;161(7):953-8.
1999: Zenia Marian Larsen; Ole P Kristiansen; E Mato; Jesper Johannesen; M Puig-Domingo; Alberto de Leiva; Jørn Nerup; Flemming Pociot
IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent).
Autoimmunity 1999;31(1):35-42.
1999: Ole P Kristiansen; Zenia Marian Larsen; Jesper Johannesen; Jørn Nerup; Thomas Mandrup-Poulsen; Flemming Pociot
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
Human mutation 1999;14(1):67-70.
1998: Flemming Pociot; PM Hansen; Allan E Karlsen; B L Langdahl; Jesper Johannesen; Jørn Nerup
TGF-beta1 gene mutations in insulin-dependent diabetes mellitus and diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 1998;9(12):2302-7.
1998: T Lorenzen; Flemming Pociot; L Stilgren; Ole P Kristiansen; Jesper Johannesen; P B Olsen; A Walmar; A Larsen; N C Albrechtsen; P C Eskildsen; O O Andersen; Jørn Nerup
Predictors of IDDM recurrence risk in offspring of Danish IDDM patients. Danish IDDM Epidemiology and Genetics Group.
Diabetologia 1998;41(6):666-73.
1998: Ole P Kristiansen; M Zamani; Jesper Johannesen; Thomas Mandrup-Poulsen; J J Cassiman; Jørn Nerup; Flemming Pociot
Linkage and association between a CD4 gene polymorphism and IDDM in Danish IDDM patients. The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood.
Diabetes 1998;47(2):281-3.
1997: Jesper Johannesen; Allan E Karlsen; Jørn Nerup; Flemming Pociot
No association or linkage to IDDM of an interferon regulatory factor-1 gene polymorphism in a Danish population. The Danish Study Group for Diabetes in Childhood.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1997;24(5):377-83.
1997: Jesper Johannesen; K F Petersen; M Berger; C Binder
New insulins and other possible therapeutic approaches.
Diabetologia 1997;40 Suppl 3():B89-93.
1997: Flemming Pociot; Riitta Veijola; Jesper Johannesen; PM Hansen; T Lorenzen; Allan E Karlsen; Helena Reijonen; Mikael Knip; Jørn Nerup
Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes mellitus (IDDM) patients and control subjects. Danish Study Group of Diabetes in Childhood.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(2):87-93.
1995: R Bergholdt; Allan E Karlsen; Jesper Johannesen; PM Hansen; C A Dinarello; Jørn Nerup; Flemming Pociot
Characterization of polymorphisms of an interleukin 1 receptor type 1 gene (IL1RI) promotor region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). The Danish Study Group of Diabetes in Childhood.
Cytokine 1995;7(7):727-33.
1994: Flemming Pociot; K S Rønningen; R Bergholdt; T Lorenzen; Jesper Johannesen; K Ye; C A Dinarello; Jørn Nerup
Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood.
Autoimmunity 1994;19(3):169-78.
1991: S Helqvist; B S Polla; Jesper Johannesen; Jørn Nerup
Heat shock protein induction in rat pancreatic islets by recombinant human interleukin 1 beta.
Diabetologia 1991;34(3):150-6.
1990: Jesper Johannesen; S Helqvist; Jørn Nerup
Not all insulin secretagogues sensitize pancreatic islets to recombinant human interleukin 1 beta.
Acta endocrinologica 1990;123(4):445-52.
1990: S Helqvist; P N Bouchelouche; Jesper Johannesen; Jørn Nerup
Interleukin 1 beta increases the cytosolic free sodium concentration in isolated rat islets of Langerhans.
Scandinavian journal of immunology 1990;32(1):53-8.
1990: L Wogensen; S Helqvist; Flemming Pociot; Jesper Johannesen; J Reimers; Thomas Mandrup-Poulsen; Jørn Nerup
Intra-peritoneal administration of interleukin-1 beta induces impaired insulin release from the perfused rat pancreas.
Autoimmunity 1990;7(1):1-12.
1990: Thomas Mandrup-Poulsen; S Helqvist; L D Wogensen; J Mølvig; Flemming Pociot; Jesper Johannesen; Jørn Nerup
Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells.
Current topics in microbiology and immunology 1990;164():169-93.
1989: S Helqvist; B Sehested Hansen; Jesper Johannesen; H Ullits Andersen; J Hoiriis Nielsen; Jørn Nerup
Interleukin 1 induces new protein formation in isolated rat islets of Langerhans.
Acta endocrinologica 1989;121(1):136-40.