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Walter Baase

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Walter A Baase; Lijun Liu; Dale E Tronrud; Brian W Matthews
Lessons from the lysozyme of phage T4.
Lijun Liu; Walter A Baase; Miya M Michael; Brian W Matthews
Use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in T4 lysozyme.
Blaine Mooers; Walter A Baase; Jonathan W Wray; Brian W Matthews
Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme.

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All Publications

2010: Walter A Baase; Lijun Liu; Dale E Tronrud; Brian W Matthews
Lessons from the lysozyme of phage T4.
Protein science : a publication of the Protein Society 2010;19(4):631-41.
2009: Lijun Liu; Walter A Baase; Miya M Michael; Brian W Matthews
Use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in T4 lysozyme.
Biochemistry 2009;48(37):8842-51.
2009: Blaine Mooers; Walter A Baase; Jonathan W Wray; Brian W Matthews
Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme.
Protein science : a publication of the Protein Society 2009;18(5):871-80.
2009: Walter A Baase; Davis Jose; Benjamin C Ponedel; Peter H von Hippel; Neil P Johnson
DNA models of trinucleotide frameshift deletions: the formation of loops and bulges at the primer-template junction.
Nucleic acids research 2009;37(5):1682-9.
2009: Lijun Liu; Walter A Baase; Brian W Matthews
Halogenated benzenes bound within a non-polar cavity in T4 lysozyme provide examples of I...S and I...Se halogen-bonding.
Journal of molecular biology 2009;385(2):595-605.
2008: Nozomi Ando; Buz Barstow; Walter A Baase; Andrew Fields; Brian W Matthews; Sol M Gruner
Structural and thermodynamic characterization of T4 lysozyme mutants and the contribution of internal cavities to pressure denaturation.
Biochemistry 2008;47(42):11097-109.
2006: Martin Sagermann; Walter A Baase; Brian W Matthews
Sequential reorganization of beta-sheet topology by insertion of a single strand.
Protein science : a publication of the Protein Society 2006;15(5):1085-92.
2006: Mohammad S Yousef; Nicole Bischoff; Collin M Dyer; Walter A Baase; Brian W Matthews
Guanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered T4 lysozyme.
Protein science : a publication of the Protein Society 2006;15(4):853-61.
2005: Neil P Johnson; Walter A Baase; Peter H von Hippel
Low energy CD of RNA hairpin unveils a loop conformation required for lambdaN antitermination activity.
The Journal of biological chemistry 2005;280(37):32177-83.
2005: Neil P Johnson; Walter A Baase; Peter H von Hippel
Investigating local conformations of double-stranded DNA by low-energy circular dichroism of pyrrolo-cytosine.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7169-73.
2004: Molly M He; Zachary A. Wood; Walter A Baase; Hong Xiao; Brian W Matthews
Alanine-scanning mutagenesis of the beta-sheet region of phage T4 lysozyme suggests that tertiary context has a dominant effect on beta-sheet formation.
Protein science : a publication of the Protein Society 2004;13(10):2716-24.
2004: Mohammad S Yousef; Walter A Baase; Brian W Matthews
Use of sequence duplication to engineer a ligand-triggered, long-distance molecular switch in T4 lysozyme.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11583-6.
2004: Richard Kingston; Walter A Baase; Leslie Gay
Characterization of nucleocapsid binding by the measles virus and mumps virus phosphoproteins.
Journal of virology 2004;78(16):8630-40.
2004: Neil P Johnson; Walter A Baase; Peter H von Hippel
Low-energy circular dichroism of 2-aminopurine dinucleotide as a probe of local conformation of DNA and RNA.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3426-31.
2004: Martin Sagermann; Walter A Baase; Blaine Mooers; Leslie Gay; Brian W Matthews
Relocation or duplication of the helix A sequence of T4 lysozyme causes only modest changes in structure but can increase or decrease the rate of folding.
Biochemistry 2004;43(5):1296-301.
2003: Blaine Mooers; Deepshikha Datta; Walter A Baase; Eric S Zollars; Stephen L Mayo; Brian W Matthews
Repacking the Core of T4 lysozyme by automated design.
Journal of molecular biology 2003;332(3):741-56.
2003: Nadine C Gassner; Walter A Baase; Blaine Mooers; Robert D Busam; Larry H Weaver; Joel D Lindstrom; Michael L Quillin; Brian W Matthews
Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability.
Biophysical chemistry 2003;100(1-3):325-40.
2002: Xue-jun Zhang; Walter A Baase; Brian W Matthews
A helix initiation signal in T4 lysozyme identified by polyalanine mutagenesis.
Biophysical chemistry 2002;101-102():43-56.
2002: Binqing Q Wei; Walter A Baase; Larry H Weaver; Brian W Matthews; Brian Shoichet
A model binding site for testing scoring functions in molecular docking.
Journal of molecular biology 2002;322(2):339-55.
2002: Martin Sagermann; Lars-Göran Mårtensson; Walter A Baase; Brian W Matthews
A test of proposed rules for helix capping: implications for protein design.
Protein science : a publication of the Protein Society 2002;11(3):516-21.
2001: J Xu; Walter A Baase; Michael L Quillin; EP Baldwin; Brian W Matthews
Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme.
Protein science : a publication of the Protein Society 2001;10(5):1067-78.
2001: Andrew Su; David M Lorber; GS Weston; Walter A Baase; B W Matthews; Brian Shoichet
Docking molecules by families to increase the diversity of hits in database screens: computational strategy and experimental evaluation.
Proteins 2001;42(2):279-93.
2000: J W Wray; Walter A Baase; Gerard J. Ostheimer; X J Zhang; Brian W Matthews
Use of a non-rigid region in T4 lysozyme to design an adaptable metal-binding site.
Protein engineering 2000;13(5):313-21.
2000: R Liu; Walter A Baase; Brian W Matthews
The introduction of strain and its effects on the structure and stability of T4 lysozyme.
Journal of molecular biology 2000;295(1):127-45.
2000: G Yang; Ciro Cecconi; Walter A Baase; I R Vetter; Wendy A. Breyer; J A Haack; Brian W Matthews; Frederick W Dahlquist; Carlos Bustamante
Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):139-44.
1999: Nadine C Gassner; Walter A Baase; Andrew C Hausrath; Brian W Matthews
Substitution with selenomethionine can enhance the stability of methionine-rich proteins.
Journal of molecular biology 1999;294(1):17-20.
1999: Nadine C Gassner; Walter A Baase; Joel D Lindstrom; J Lu; Frederick W Dahlquist; Brian W Matthews
Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry 1999;38(44):14451-60.
1999: J W Wray; Walter A Baase; Joel D Lindstrom; Larry H Weaver; A R Poteete; Brian W Matthews
Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability.
Journal of molecular biology 1999;292(5):1111-20.
1999: Martin Sagermann; Walter A Baase; Brian W Matthews
Structural characterization of an engineered tandem repeat contrasts the importance of context and sequence in protein folding.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6078-83.
1999: Beth M Beadle; Walter A Baase; D B Wilson; Neil Gilkes; Brian Shoichet
Comparing the thermodynamic stabilities of a related thermophilic and mesophilic enzyme.
Biochemistry 1999;38(8):2570-6.
1998: EP Baldwin; Walter A Baase; X j Zhang; Victoria A Feher; Brian W Matthews
Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions.
Journal of molecular biology 1998;277(2):467-85.
1998: L A Lipscomb; Nadine C Gassner; S D Snow; A M Eldridge; Walter A Baase; D L Drew; Brian W Matthews
Context-dependent protein stabilization by methionine-to-leucine substitution shown in T4 lysozyme.
Protein science : a publication of the Protein Society 1998;7(3):765-73.
1998: J Xu; Walter A Baase; EP Baldwin; Brian W Matthews
The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect.
Protein science : a publication of the Protein Society 1998;7(1):158-77.
1996: I R Vetter; Walter A Baase; D W Heinz; J P Xiong; S Snow; Brian W Matthews
Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme.
Protein science : a publication of the Protein Society 1996;5(12):2399-415.
1996: Nadine C Gassner; Walter A Baase; Brian W Matthews
A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12155-8.
1996: E Baldwin; J Xu; O Hajiseyedjavadi; Walter A Baase; Brian W Matthews
Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
Journal of molecular biology 1996;259(3):542-59.
1995: X J Zhang; Walter A Baase; Brian Shoichet; K P Wilson; Brian W Matthews
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive.
Protein engineering 1995;8(10):1017-22.
1995: A Morton; Walter A Baase; Brian W Matthews
Energetic origins of specificity of ligand binding in an interior nonpolar cavity of T4 lysozyme.
Biochemistry 1995;34(27):8564-75.
1995: M Blaber; Walter A Baase; Nadine C Gassner; Brian W Matthews
Alanine scanning mutagenesis of the alpha-helix 115-123 of phage T4 lysozyme: effects on structure, stability and the binding of solvent.
Journal of molecular biology 1995;246(2):317-30.
1995: Brian Shoichet; Walter A Baase; Ryota Kuroki; Brian W Matthews
A relationship between protein stability and protein function.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):452-6.
1994: N P Johnson; J Lindstrom; Walter A Baase; Peter H von Hippel
Double-stranded DNA templates can induce alpha-helical conformation in peptides containing lysine and alanine: functional implications for leucine zipper and helix-loop-helix transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4840-4.
1994: D W Heinz; Walter A Baase; X J Zhang; M Blaber; Frederick W Dahlquist; Brian W Matthews
Accommodation of amino acid insertions in an alpha-helix of T4 lysozyme. Structural and thermodynamic analysis.
Journal of molecular biology 1994;236(3):869-86.
1994: M Blaber; X J Zhang; J D Lindstrom; S D Pepiot; Walter A Baase; Brian W Matthews
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
Journal of molecular biology 1994;235(2):600-24.
1993: E P Baldwin; O Hajiseyedjavadi; Walter A Baase; Brian W Matthews
The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme.
Science (New York, N.Y.) 1993;262(5140):1715-8.
1993: P Pjura; M Matsumura; Walter A Baase; Brian W Matthews
Development of an in vivo method to identify mutants of phage T4 lysozyme of enhanced thermostability.
Protein science : a publication of the Protein Society 1993;2(12):2217-25.
1993: G C Flynn; Cornelis Beckers; Walter A Baase; Frederick W Dahlquist
Individual subunits of bacterial luciferase are molten globules and interact with molecular chaperones.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10826-30.
1993: D E Anderson; J H Hurley; H Nicholson; Walter A Baase; Brian W Matthews
Hydrophobic core repacking and aromatic-aromatic interaction in the thermostable mutant of T4 lysozyme Ser 117-->Phe.
Protein science : a publication of the Protein Society 1993;2(8):1285-90.
1993: D W Heinz; Walter A Baase; Frederick W Dahlquist; Brian W Matthews
How amino-acid insertions are allowed in an alpha-helix of T4 lysozyme.
Nature 1993;361(6412):561-4.
1993: A E Eriksson; Walter A Baase; Brian W Matthews
Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences.
Journal of molecular biology 1993;229(3):747-69.
1992: M M Dixon; H Nicholson; L Shewchuk; Walter A Baase; Brian W Matthews
Structure of a hinge-bending bacteriophage T4 lysozyme mutant, Ile3-->Pro.
Journal of molecular biology 1992;227(3):917-33.
1992: J Lu; Walter A Baase; D C Muchmore; Frederick W Dahlquist
Protein folding: assignment of the energetic changes of reversible chemical modifications to the folded or unfolded states.
Biochemistry 1992;31(34):7765-72.
1992: X J Zhang; Walter A Baase; Brian W Matthews
Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
Protein science : a publication of the Protein Society 1992;1(6):761-76.
1992: D W Heinz; Walter A Baase; Brian W Matthews
Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3751-5.
1992: J H Hurley; Walter A Baase; Brian W Matthews
Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme.
Journal of molecular biology 1992;224(4):1143-59.
1992: J A Bell; W J Becktel; U Sauer; Walter A Baase; Brian W Matthews
Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59.
Biochemistry 1992;31(14):3590-6.
1992: B L Chen; Walter A Baase; H Nicholson; John A Schellman
Folding kinetics of T4 lysozyme and nine mutants at 12 degrees C.
Biochemistry 1992;31(5):1464-76.
1992: A E Eriksson; Walter A Baase; J A Wozniak; Brian W Matthews
A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene.
Nature 1992;355(6358):371-3.
1992: A E Eriksson; Walter A Baase; X J Zhang; D W Heinz; M Blaber; E P Baldwin; Brian W Matthews
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect.
Science (New York, N.Y.) 1992;255(5041):178-83.
1992: Walter A Baase; A E Eriksson; X J Zhang; D W Heinz; U Sauer; M Blaber; E P Baldwin; J A Wozniak; Brian W Matthews
Dissection of protein structure and folding by directed mutagenesis.
Faraday discussions 1992;(93):173-81.
1991: S Dao-pin; D E Anderson; Walter A Baase; Frederick W Dahlquist; Brian W Matthews
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme.
Biochemistry 1991;30(49):11521-9.
1991: S Dao-pin; E Söderlind; Walter A Baase; J A Wozniak; U Sauer; Brian W Matthews
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
Journal of molecular biology 1991;221(3):873-87.
1991: S Daopin; Thomas Alber; Walter A Baase; J A Wozniak; Brian W Matthews
Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme.
Journal of molecular biology 1991;221(2):647-67.
1991: X J Zhang; Walter A Baase; Brian W Matthews
Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme.
Biochemistry 1991;30(8):2012-7.
1991: S Dao-pin; H Nicholson; Walter A Baase; X J Zhang; J A Wozniak; Brian W Matthews
Structural and genetic analysis of electrostatic and other interactions in bacteriophage T4 lysozyme.
Ciba Foundation symposium 1991;161():52-62.
1990: S Dao-Pin; Walter A Baase; Brian W Matthews
A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix.
Proteins 1990;7(2):198-204.
1989: M Karpusas; Walter A Baase; M Matsumura; Brian W Matthews
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8237-41.
1989: B L Chen; Walter A Baase; John A Schellman
Low-temperature unfolding of a mutant of phage T4 lysozyme. 2. Kinetic investigations.
Biochemistry 1989;28(2):691-9.
1988: R Wetzel; L J Perry; Walter A Baase; W J Becktel
Disulfide bonds and thermal stability in T4 lysozyme.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):401-5.
1987: W J Becktel; Walter A Baase
Thermal denaturation of bacteriophage T4 lysozyme at neutral pH.
Biopolymers 1987;26(5):619-23.
1985: W J Becktel; Walter A Baase
A lysoplate assay for Escherichia coli cell wall-active enzymes.
Analytical biochemistry 1985;150(2):258-63.