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Timor Baasov

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Cornelia Brendel; Jutta Gärtner; Timor Baasov; Valery Belakhov; Igor Nudelman; Eike Wegener; Hauke Werner; Peter Huppke
Erratum to: Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model.
Moran Shalev; Nir Skalka; Valery Belakhov; Jeyakumar Kandasamy; Rina Rosin-Arbesfeld; Timor Baasov
Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH group for the treatment of genetic diseases in biological samples.
Kim M Keeling; Srinivasan Murugesan; Sadanandan E Velu; Dan Wang; Valery Belakhov; Balachandra Chenna; Jeremy Clark; Yanying Dai; Jeyakumar Kandasamy; Timor Baasov; David M Bedwell
Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression.

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2013: Cornelia Brendel; Jutta Gärtner; Timor Baasov; Valery Belakhov; Igor Nudelman; Eike Wegener; Hauke Werner; Peter Huppke
Erratum to: Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model.
Journal of molecular medicine (Berlin, Germany) 2013;91(6):775.
2013: Moran Shalev; Nir Skalka; Valery Belakhov; Jeyakumar Kandasamy; Rina Rosin-Arbesfeld; Timor Baasov
Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH group for the treatment of genetic diseases in biological samples.
Journal of pharmaceutical and biomedical analysis 2013;75():33-40.
2013: Kim M Keeling; Srinivasan Murugesan; Sadanandan E Velu; Dan Wang; Valery Belakhov; Balachandra Chenna; Jeremy Clark; Yanying Dai; Jeyakumar Kandasamy; Timor Baasov; David M Bedwell
Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression.
PloS one 2013;8(4):e60478.
2012: Jeyakumar Kandasamy; Katya Shapira; Michal Shavit; Eli Shulman; Dana Atia-Glikin; Valery Belakhov; Timor Baasov
Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations.
Journal of medicinal chemistry 2012;55(23):10630-43.
2012: Tobias Goldmann; Fabian Möller; Timor Baasov; Valery Belakhov; Nora Overlack; Michiel van Wyk; Uwe Wolfrum; Kerstin Nagel-Wolfrum
A comparative evaluation of NB30, NB54 and PTC124 in translational read-through efficacy for treatment of an USH1C nonsense mutation.
EMBO molecular medicine 2012;4(11):1186-99.
2011: Steven M Rowe; Erik M Schwiebert; Peter Sloane; Li Ping Tang; Timor Baasov; Kyle Backer; Zsuzsa Bebok; Valery Belakhov; Jessica Buckley-Lanier; Marina Mazur; Igor Nudelman; David M Bedwell
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54.
Journal of molecular medicine (Berlin, Germany) 2011;89(11):1149-61.
2011: Hui-Ling Rose Lee; Yacov Ron; Timor Baasov; Chiann-Chyi Chen; Joseph P Dougherty
Post-transcriptionally regulated expression system in human xenogeneic transplantation models.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(9):1645-55.
2011: Cornelia Brendel; Valery Belakhov; Hauke Werner; Eike Wegener; Jutta Gärtner; Igor Nudelman; Timor Baasov; Peter Huppke
Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model.
Journal of molecular medicine (Berlin, Germany) 2011;89(4):389-98.
2011: Manuela Vecsler; Igor Nudelman; Gideon Rechavi; Amos J Simon; Ninette Amariglio; Yair Anikster; Timor Baasov; Bruria Ben-Zeev; Eva Gak
Ex vivo treatment with a novel synthetic aminoglycoside NB54 in primary fibroblasts from Rett syndrome patients suppresses MECP2 nonsense mutations.
PloS one 2011;6(6):e20733.
2010: Tobias Goldmann; Annie Rebibo-Sabbah; Nora Overlack; Igor Nudelman; Valery Belakhov; Timor Baasov; Tamar Ben-Yosef; Uwe Wolfrum; Kerstin Nagel-Wolfrum
Beneficial read-through of a USH1C nonsense mutation by designed aminoglycoside NB30 in the retina.
Investigative ophthalmology & visual science 2010;51(12):6671-80.
2010: Varvara Pokrovskaya; Timor Baasov
Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance.
Expert opinion on drug discovery 2010;5(9):883-902.
2010: Igor Nudelman; Dana Glikin; Boris Smolkin; Mariana Hainrichson; Valery Belakhov; Timor Baasov
Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations.
Bioorganic & medicinal chemistry 2010;18(11):3735-46.
2010: Varvara Pokrovskaya; Igor Nudelman; Jeyakumar Kandasamy; Timor Baasov
Aminoglycosides redesign strategies for improved antibiotics and compounds for treatment of human genetic diseases.
Methods in enzymology 2010;478():437-62.
2009: Igor Nudelman; Annie Rebibo-Sabbah; Marina Cherniavsky; Valery Belakhov; Mariana Hainrichson; Fuquan Chen; Jochen Schacht; Daniel S Pilch; Tamar Ben-Yosef; Timor Baasov
Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.
Journal of medicinal chemistry 2009;52(9):2836-45.
2009: Varvara Pokrovskaya; Valery Belakhov; Mariana Hainrichson; Sima Yaron; Timor Baasov
Design, synthesis, and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics.
Journal of medicinal chemistry 2009;52(8):2243-54.
2008: Lilach Chen; Mariana Hainrichson; Dmitry Bourdetsky; Amram Mor; Sima Yaron; Timor Baasov
Structure-toxicity relationship of aminoglycosides: correlation of 2'-amine basicity with acute toxicity in pseudo-disaccharide scaffolds.
Bioorganic & medicinal chemistry 2008;16(19):8940-51.
2008: Ofir Menashe; Elena Kaganskaya; Timor Baasov; Sima Yaron
Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
Antimicrobial agents and chemotherapy 2008;52(3):920-6.
2008: Mariana Hainrichson; Igor Nudelman; Timor Baasov
Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases.
Organic & biomolecular chemistry 2008;6(2):227-39.
2007: Annie Rebibo-Sabbah; Igor Nudelman; Zubair M Ahmed; Timor Baasov; Tamar Ben-Yosef
In vitro and ex vivo suppression by aminoglycosides of PCDH15 nonsense mutations underlying type 1 Usher syndrome.
Human genetics 2007;122(3-4):373-81.
2007: Jiro KONDO; Mariana Hainrichson; Igor Nudelman; Dalia Shallom-Shezifi; Christopher M Barbieri; Daniel S Pilch; Eric Westhof; Timor Baasov
Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites.
Chembiochem : a European journal of chemical biology 2007;8(14):1700-9.
2007: Mariana Hainrichson; Orit Yaniv; Marina Cherniavsky; Igor Nudelman; Dalia Shallom-Shezifi; Sima Yaron; Timor Baasov
Overexpression and initial characterization of the chromosomal aminoglycoside 3'-O-phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy 2007;51(2):774-6.
2006: Igor Nudelman; Annie Rebibo-Sabbah; Dalia Shallom-Shezifi; Mariana Hainrichson; Ido Stahl; Tamar Ben-Yosef; Timor Baasov
Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations.
Bioorganic & medicinal chemistry letters 2006;16(24):6310-5.
2005: Mariana Hainrichson; Varvara Pokrovskaya; Dalia Shallom-Shezifi; Micha Fridman; Valery Belakhov; Dina Shachar; Sima Yaron; Timor Baasov
Branched aminoglycosides: biochemical studies and antibacterial activity of neomycin B derivatives.
Bioorganic & medicinal chemistry 2005;13(20):5797-807.
2005: Radion Vainer; Valery Belakhov; Emilia Rabkin; Timor Baasov; Noam Adir
Crystal structures of Escherichia coli KDO8P synthase complexes reveal the source of catalytic irreversibility.
Journal of molecular biology 2005;351(3):641-52.
2005: Cristina M Furdui; Apurba K Sau; Orit Yaniv; Valery Belakhov; Ronald W Woodard; Timor Baasov; Karen S Anderson
The use of (E)- and (Z)-phosphoenol-3-fluoropyruvate as mechanistic probes reveals significant differences between the active sites of KDO8P and DAHP synthases.
Biochemistry 2005;44(19):7326-35.
2005: Dalia Shallom; Maya Leon; Tsafrir Bravman; Alon Ben-David; Galia Zaide; Valery Belakhov; Gil Shoham; Dietmar Schomburg; Timor Baasov; Yuval Shoham
Biochemical characterization and identification of the catalytic residues of a family 43 beta-D-xylosidase from Geobacillus stearothermophilus T-6.
Biochemistry 2005;44(1):387-97.
2005: Micha Fridman; Valery Belakhov; Lac V Lee; Fu-Sen Liang; Chi-Huey Wong; Timor Baasov
Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor.
Angewandte Chemie (International ed. in English) 2005;44(3):447-52.
2004: Smadar Shulami; Cristina M Furdui; Noam Adir; Yuval Shoham; Karen S Anderson; Timor Baasov
A reciprocal single mutation affects the metal requirement of 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) synthases from Aquifex pyrophilus and Escherichia coli.
The Journal of biological chemistry 2004;279(43):45110-20.
2004: Gali Golan; Dalia Shallom; Anna Teplitsky; Galia Zaide; Smadar Shulami; Timor Baasov; vivian stojanoff; Andy Thompson; Yuval Shoham; Gil Shoham
Crystal structures of Geobacillus stearothermophilus alpha-glucuronidase complexed with its substrate and products: mechanistic implications.
The Journal of biological chemistry 2004;279(4):3014-24.
2004: Valery Belakhov; Ekaterina Dovgolevsky; Emilia Rabkin; Smadar Shulami; Yuval Shoham; Timor Baasov
Synthesis and evaluation of a mechanism-based inhibitor of KDO8P synthase.
Carbohydrate research 2004;339(2):385-92.
2003: Smadar Shulami; Orit Yaniv; Emilia Rabkin; Yuval Shoham; Timor Baasov
Cloning, expression, and biochemical characterization of 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) synthase from the hyperthermophilic bacterium Aquifex pyrophilus.
Extremophiles : life under extreme conditions 2003;7(6):471-81.
2003: Eyal Shimoni; Timor Baasov; Uzi Ravid; Yuval Shoham
Biotransformations of propenylbenzenes by an Arthrobacter sp. and its t-anethole blocked mutants.
Journal of biotechnology 2003;105(1-2):61-70.
2003: Micha Fridman; Valery Belakhov; Sima Yaron; Timor Baasov
A new class of branched aminoglycosides: pseudo-pentasaccharide derivatives of neomycin B.
Organic letters 2003;5(20):3575-8.
2003: Klaus Hövel; Dalia Shallom; Karsten Niefind; Valery Belakhov; Gil Shoham; Timor Baasov; Yuval Shoham; Dietmar Schomburg
Crystal structure and snapshots along the reaction pathway of a family 51 alpha-L-arabinofuranosidase.
The EMBO journal 2003;22(19):4922-32.
2003: Tsafrir Bravman; Gennady Zolotnitsky; Valery Belakhov; Gil Shoham; Bernard Henrissat; Timor Baasov; Yuval Shoham
Detailed kinetic analysis of a family 52 glycoside hydrolase: a beta-xylosidase from Geobacillus stearothermophilus.
Biochemistry 2003;42(35):10528-36.
2003: Zhili Li; Apurba K Sau; Shida Shen; Craig Whitehouse; Timor Baasov; Karen S Anderson
A snapshot of enzyme catalysis using electrospray ionization mass spectrometry.
Journal of the American Chemical Society 2003;125(33):9938-9.
2003: Lilia Kaustov; Timor Baasov; Asher Schmidt
Binding of the natural substrates and products to KDO8P synthase: 31P and 13C solution NMR characterization.
Bioorganic chemistry 2003;31(4):306-21.
2003: Tsafrir Bravman; Valery Belakhov; Dmitry Solomon; Gil Shoham; Bernard Henrissat; Timor Baasov; Yuval Shoham
Identification of the catalytic residues in family 52 glycoside hydrolase, a beta-xylosidase from Geobacillus stearothermophilus T-6.
The Journal of biological chemistry 2003;278(29):26742-9.
2003: Klaus Hövel; Dalia Shallom; Karsten Niefind; Timor Baasov; Gil Shoham; Yuval Shoham; Dietmar Schomburg
Crystallization and preliminary X-ray analysis of a family 51 glycoside hydrolase, the alpha-l-arabinofuranosidase from Geobacillus stearothermophilus T-6.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 5):913-5.
2003: Lilia Kaustov; Shifi Kababya; Valery Belakhov; Timor Baasov; Yuval Shoham; Asher Schmidt
Inhibition mode of a bisubstrate inhibitor of KDO8P synthase: a frequency-selective REDOR solid-state and solution NMR characterization.
Journal of the American Chemical Society 2003;125(15):4662-9.
2002: Dalia Shallom; Valery Belakhov; Dmitry Solomon; Gil Shoham; Timor Baasov; Yuval Shoham
Detailed kinetic analysis and identification of the nucleophile in alpha-L-arabinofuranosidase from Geobacillus stearothermophilus T-6, a family 51 glycoside hydrolase.
The Journal of biological chemistry 2002;277(46):43667-73.
2002: Valery Belakhov; Mark Botoshansky; Timor Baasov
Methyl 2,3-dideoxy-2-S-methylmercurio-2-thio-beta-D-manno-oct-2-ulopyranosonate-(2,6).
Acta crystallographica. Section C, Crystal structure communications 2002;58(Pt 8):m450-2.
2002: Eyal Shimoni; Timor Baasov; Uzi Ravid; Yuval Shoham
The trans-anethole degradation pathway in an Arthrobacter sp.
The Journal of biological chemistry 2002;277(14):11866-72.
2002: Dalia Shallom; Valery Belakhov; Dmitry Solomon; Sara Gilead-Gropper; Timor Baasov; Gil Shoham; Yuval Shoham
The identification of the acid-base catalyst of alpha-arabinofuranosidase from Geobacillus stearothermophilus T-6, a family 51 glycoside hydrolase.
FEBS letters 2002;514(2-3):163-7.
2002: Micha Fridman; Dmitry Solomon; Shay Yogev; Timor Baasov
One-pot synthesis of glucosamine oligosaccharides.
Organic letters 2002;4(2):281-3.
2001: Dmitry Solomon; Micha Fridman; J Zhang; Timor Baasov
A synthetic pentasaccharide with GTPase activity.
Organic letters 2001;3(26):4311-4.
2001: O Asojo; J Friedman; Noam Adir; Valery Belakhov; Yuval Shoham; Timor Baasov
Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor.
Biochemistry 2001;40(21):6326-34.
2001: Galia Zaide; Dalia Shallom; Smadar Shulami; Gennady Zolotnitsky; Gali Golan; Timor Baasov; Gil Shoham; Yuval Shoham
Biochemical characterization and identification of catalytic residues in alpha-glucuronidase from Bacillus stearothermophilus T-6.
European journal of biochemistry / FEBS 2001;268(10):3006-16.
2001: Tsafrir Bravman; Adva Mechaly; Smadar Shulami; Valery Belakhov; Timor Baasov; Gil Shoham; Yuval Shoham
Glutamic acid 160 is the acid-base catalyst of beta-xylosidase from Bacillus stearothermophilus T-6: a family 39 glycoside hydrolase.
FEBS letters 2001;495(1-2):115-9.
2001: Tsafrir Bravman; Gennady Zolotnitsky; Smadar Shulami; Valery Belakhov; Dmitry Solomon; Timor Baasov; Gil Shoham; Yuval Shoham
Stereochemistry of family 52 glycosyl hydrolases: a beta-xylosidase from Bacillus stearothermophilus T-6 is a retaining enzyme.
FEBS letters 2001;495(1-2):39-43.
2000: Lilia Kaustov; Shifi Kababya; S Du; Timor Baasov; S Gropper; Yuval Shoham; Asher Schmidt
Structural and mechanistic investigation of 3-deoxy-D-manno-octulosonate-8-phosphate synthase by solid-state REDOR NMR.
Biochemistry 2000;39(48):14865-76.
2000: Adva Mechaly; Anna Teplitsky; Valery Belakhov; Timor Baasov; Gil Shoham; Yuval Shoham
Overproduction and characterization of seleno-methionine xylanase T-6.
Journal of biotechnology 2000;78(1):83-6.
1999: S Du; H Faiger; Valery Belakhov; Timor Baasov
Towards the development of novel antibiotics: synthesis and evaluation of a mechanism-based inhibitor of Kdo8P synthase.
Bioorganic & medicinal chemistry 1999;7(12):2671-82.
1998: P H Liang; J Lewis; Karen S Anderson; A Kohen; F W D'Souza; Y Benenson; Timor Baasov
Catalytic mechanism of Kdo8P synthase: transient kinetic studies and evaluation of a putative reaction intermediate.
Biochemistry 1998;37(46):16390-9.
1993: Timor Baasov; S Sheffer-Dee-Noor; A Kohen; A Jakob; V Belakhov
Catalytic mechanism of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase. The use of synthetic analogues to probe the structure of the putative reaction intermediate.
European journal of biochemistry / FEBS 1993;217(3):991-9.
1992: A Kohen; A Jakob; Timor Baasov
Mechanistic studies of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase from Escherichia coli.
European journal of biochemistry / FEBS 1992;208(2):443-9.