FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Gary Johnson

Research Profile

Physiology

Chemicals & Drugs

Co-author Network

Publications

TOP 3
Jon S Zawistowski; Brian T Golitz; Deborah A Granger; Kazuhiro Nakamura; Joel S Parker; Gary L Johnson
MicroRNA 9-3p Targets β1 Integrin To Sensitize Claudin-Low Breast Cancer Cells to MEK Inhibition.
Lee M Graves; James S Duncan; Martin C Whittle; Gary L Johnson
The dynamic nature of the kinome.
Patrick J Dillon; Dirk P Dittmer; Sean M Gregory; Gary L Johnson; Nancy Raab-Traub; Marcia K Sanders; Kristen Tamburro; Blossom Damania
Tousled-like kinases modulate reactivation of gammaherpesviruses from latency.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Gary Johnson (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Jon S Zawistowski; Brian T Golitz; Deborah A Granger; Kazuhiro Nakamura; Joel S Parker; Gary L Johnson
MicroRNA 9-3p Targets β1 Integrin To Sensitize Claudin-Low Breast Cancer Cells to MEK Inhibition.
Molecular and cellular biology 2013;33(11):2260-74.
2013: Lee M Graves; James S Duncan; Martin C Whittle; Gary L Johnson
The dynamic nature of the kinome.
The Biochemical journal 2013;450(1):1-8.
2013: Patrick J Dillon; Dirk P Dittmer; Sean M Gregory; Gary L Johnson; Nancy Raab-Traub; Marcia K Sanders; Kristen Tamburro; Blossom Damania
Tousled-like kinases modulate reactivation of gammaherpesviruses from latency.
Cell host & microbe 2013;13(2):204-14.
2013: Bryan T Richardson; Asya L Borikova; Christopher F Dibble; Gary L Johnson
Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling.
Biological chemistry 2013;394(1):35-42.
2012: M R Cronan; Bruce D Cuevas; H G Dohlman; D A Granger; Nancy L Johnson; N Mackman; Kazuhiro Nakamura; J E Scott; J-G Wang; Gary L Johnson
Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis.
Oncogene 2012;31(34):3889-900.
2012: James S Duncan; H Shelton Earp; Stephen V Frye; Shawn M Gomez; Deborah A Granger; Lee M Graves; Xiaping He; Katherine A Hoadley; Jian Jin; Nancy L Johnson; Nicole Vincent Jordan; William Y Kim; Pei-Fen Kuan; Ben Major; Alicia A Midland; Kazuhiro Nakamura; Charles M Perou; Norman E Sharpless; David M Smalley; Jerry Usary; Martin C Whittle; Jon S Zawistowski; Bing Zhou; Amy N Abell; Xin Chen; David B Darr; Gary L Johnson
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.
Cell 2012;149(2):307-21.
2012: Alicia A Midland; Kazuhiro Nakamura; Martin C Whittle; Jon S Zawistowski; H Shelton Earp; Amy N Abell; Lisa A Carey; James S Duncan; Shawn M Gomez; Lee M Graves; Gary L Johnson
Defining the expressed breast cancer kinome.
Cell research 2012;22(4):620-3.
2011: Weichun Huang; Gary L Johnson; David M Umbach; Nicole Vincent Jordan; Amy N Abell; Leping Li
Efficiently identifying genome-wide changes with next-generation sequencing data.
Nucleic acids research 2011;39(19):e130.
2011: Nicole Vincent Jordan; Gary L Johnson; Amy N Abell
Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer.
Cell cycle (Georgetown, Tex.) 2011;10(17):2865-73.
2011: Amy N Abell; Nicole Vincent Jordan; Weichun Huang; Aleix Prat; Alicia A Midland; Nancy L Johnson; Deborah A Granger; Piotr A Mieczkowski; Charles M Perou; Shawn M Gomez; Leping Li; Gary L Johnson
MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells.
Cell stem cell 2011;8(5):525-37.
2011: Gary L Johnson
Defining MAPK interactomes.
ACS chemical biology 2011;6(1):18-20.
2010: Asya L Borikova; Christopher F Dibble; Noah Sciaky; Christopher M Welch; Amy N Abell; Sompop Bencharit; Gary L Johnson
Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype.
The Journal of biological chemistry 2010;285(16):11760-4.
2010: Kazuhiro Nakamura; Adam Jordan Kimple; David Siderovski; Gary L Johnson
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.
The Journal of biological chemistry 2010;285(3):2077-89.
2010: Kazuhiro Nakamura; Gary L Johnson
Activity assays for extracellular signal-regulated kinase 5.
Methods in molecular biology (Clifton, N.J.) 2010;661():91-106.
2010: Christopher F Dibble; Jeremy A Horst; Michael H Malone; Kun Park; Brenda Temple; Holly Cheeseman; Justin R Barbaro; Gary L Johnson; Sompop Bencharit
Defining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate.
PloS one 2010;5(7):e11740.
2009: matthias machacek; Louis Hodgson; Christopher Welch; Hunter Elliott; Olivier Pertz; Perihan Nalbant; Amy N Abell; Gary L Johnson; Klaus M Hahn; Gaudenz Danuser
Coordination of Rho GTPase activities during cell protrusion.
Nature 2009;461(7260):99-103.
2009: Stephen Frye; Gary L Johnson
Inhibitors paradoxically prime kinases.
Nature chemical biology 2009;5(7):448-9.
2009: Lisa E S Crose; Thomas L Hilder; Noah Sciaky; Gary L Johnson
Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.
The Journal of biological chemistry 2009;284(20):13301-5.
2009: Amy N Abell; Deborah A Granger; Nancy L Johnson; Nicole Vincent-Jordan; Christopher F Dibble; Gary L Johnson
Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase.
Molecular and cellular biology 2009;29(10):2748-61.
2009: Ling Xie; Linhong Jing; Yanbao Yu; Kazuhiro Nakamura; Carol Parker; Gary L Johnson; Xian Chen
In vivo profiling endogenous interactions with knock-out in mammalian cells.
Analytical chemistry 2009;81(4):1411-7.
2009: Gary L Johnson; Shawn Gomez
Sequence patches on MAPK surfaces define protein-protein interactions.
Genome biology 2009;10(6):222.
2008: P Arora; Bruce D Cuevas; Angela Russo; Gary L Johnson; JoAnn Trejo
Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion.
Oncogene 2008;27(32):4434-45.
2008: Kazuhiro Nakamura; Jon S Zawistowski; Mark A Hughes; Jonathan Z. Sexton; Li-An Yeh; Gary L Johnson; John E Scott
Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerization.
Journal of biomolecular screening 2008;13(5):396-405.
2008: Yang Wu; Gary L Johnson; Shawn Gomez
Data-driven modeling of cellular stimulation, signaling and output response in RAW 264.7 cells.
Journal of molecular signaling 2008;3():11.
2007: Thomas L Hilder; Michael H Malone; Sompop Bencharit; John Colicelli; Timothy A J Haystead; Gary L Johnson; Christine C Wu
Proteomic identification of the cerebral cavernous malformation signaling complex.
Journal of proteome research 2007;6(11):4343-55.
2007: Ann M Winter-Vann; Gary L Johnson
Integrated activation of MAP3Ks balances cell fate in response to stress.
Journal of cellular biochemistry 2007;102(4):848-58.
2007: Amy N Abell; Deborah A Granger; Gary L Johnson
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.
The Journal of biological chemistry 2007;282(42):30476-84.
2007: Gary L Johnson; Kazuhiro Nakamura
The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.
Biochimica et biophysica acta 2007;1773(8):1341-8.
2007: Kazuhiro Nakamura; Gary L Johnson
Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling.
Molecular and cellular biology 2007;27(12):4566-77.
2007: Bruce D Cuevas; Amy N Abell; Gary L Johnson
Role of mitogen-activated protein kinase kinase kinases in signal integration.
Oncogene 2007;26(22):3159-71.
2007: Adriana Beltran Lopez; S Parikh; Yuangang Liu; Bruce D Cuevas; Gary L Johnson; Bernard W Futscher; Pilar Blancafort
Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors.
Oncogene 2007;26(19):2791-8.
2007: Thomas L Hilder; Michael H Malone; Gary L Johnson
Hyperosmotic induction of mitogen-activated protein kinase scaffolding.
Methods in enzymology 2007;428():297-312.
2007: Michael H Malone; Noah Sciaky; Lisa Stalheim; Klaus M Hahn; Elwood Linney; Gary L Johnson
Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae.
BMC biotechnology 2007;7():40.
2007: Yan Xia; Ji Wang; Shuichan Xu; Gary L Johnson; Tony Hunter; Zhimin Lu
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress.
Molecular and cellular biology 2007;27(2):510-7.
2006: Amy Kathleen Keating; D B Salzberg; Susan Sather; Xiayuan Liang; S Nickoloff; A Anwar; D Deryckere; K Hill; D Joung; K K Sawczyn; J Park; Douglas Curran-Everett; Loris McGavran; Lynne Meltesen; Lia Gore; Gary L Johnson; Douglas K. Graham
Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase.
Oncogene 2006;25(45):6092-100.
2006: Bruce D Cuevas; Ann M Winter-Vann; Nancy L Johnson; Gary L Johnson
MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer.
Oncogene 2006;25(36):4998-5010.
2006: Kazuhiro Nakamura; Mark T Uhlik; Nancy L Johnson; Klaus M Hahn; Gary L Johnson
PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation.
Molecular and cellular biology 2006;26(6):2065-79.
2005: Robert Stearman; Lori D Dwyer-Nield; Laura K Zerbe; Stacy A Blaine; Zeng Chan; Paul A Bunn; Gary L Johnson; Fred R Hirsch; Daniel T Merrick; Wilbur A Franklin; Anna E Baron; Robert L Keith; Raphael A Nemenoff; Alvin M Malkinson; Mark W Geraci
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.
The American journal of pathology 2005;167(6):1763-75.
2005: Amy N Abell; Gary L Johnson
MEKK4 is an effector of the embryonic TRAF4 for JNK activation.
The Journal of biological chemistry 2005;280(43):35793-6.
2005: Amy N Abell; Jaime A Rivera-Perez; Bruce D Cuevas; Mark T Uhlik; Susan Sather; Nancy L Johnson; Suzanne K Minton; Jean M Lauder; Ann M Winter-Vann; Kazuhiro Nakamura; Terry Magnuson; Richard R Vaillancourt; Lynn E Heasley; Gary L Johnson
Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.
Molecular and cellular biology 2005;25(20):8948-59.
2005: Jon S Zawistowski; Lisa Stalheim; Mark T Uhlik; Amy N Abell; Brooke B Ancrile; Gary L Johnson; Douglas A Marchuk
CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis.
Human molecular genetics 2005;14(17):2521-31.
2005: Gary L Johnson; Henrik G Dohlman; Lee M Graves
MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression.
Current opinion in chemical biology 2005;9(3):325-31.
2005: Yan Li; Tetsuo Minamino; Osamu Tsukamoto; Toshiaki Yujiri; Yasunori Shintani; Ken-ichiro Okada; Yoko Nagamachi; Masashi Fujita; Akio Hirata; Shoji Sanada; Hiroshi Asanuma; Seiji Takashima; Masatsugu Hori; Gary L Johnson; Masafumi Kitakaze
Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model.
Circulation 2005;111(13):1672-8.
2005: Bruce D Cuevas; Mark T Uhlik; Timothy P Garrington; Gary L Johnson
MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability.
Oncogene 2005;24(5):801-9.
2005: Mark T Uhlik; Brenda Temple; Sompop Bencharit; Adam Jordan Kimple; David Siderovski; Gary L Johnson
Structural and evolutionary division of phosphotyrosine binding (PTB) domains.
Journal of molecular biology 2005;345(1):1-20.
2004: Mark T Uhlik; Amy N Abell; Bruce D Cuevas; Kazuhiro Nakamura; Gary L Johnson
Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2004;82(6):658-63.
2004: Penny Clarke; Suzanne M Meintzer; Yibing Wang; Lisa A Moffitt; Sarah M Richardson-Burns; Gary L Johnson; Kenneth L Tyler
JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells.
Journal of virology 2004;78(23):13132-8.
2004: Marsha S Anderson; Cindy Knall; Gail Thurman; Don Mann; Nancy Cusack; Gary L Johnson; Daniel R Ambruso
CP-64131, an aminobenzazepine with cytokine-like properties, stimulates human neutrophil functions through the p38-MAPK pathway.
Journal of leukocyte biology 2004;76(2):477-83.
2004: Kamala Kesavan; Katherine Lobel-Rice; Weiyong Sun; Razvan Lapadat; Saiphone Webb; Gary L Johnson; Timothy P Garrington
MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts.
Journal of cellular physiology 2004;199(1):140-8.
2004: Jonathan G Lieber; Benjamin T Suratt; Saiphone Webb; Gary L Johnson; Gordon M Keller; Scott K Young; G Scott Worthen
The in vitro production and characterization of neutrophils from embryonic stem cells.
Blood 2004;103(3):852-9.
2004: Amy N Abell; Aimee M deCathelineau; Scott A Weed; Daniel R Ambruso; David W H Riches; Gary L Johnson
Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages.
Journal of cell science 2004;117(Pt 2):243-55.
2003: Mark T Uhlik; Amy N Abell; Nancy L Johnson; Weiyong Sun; Bruce D Cuevas; Katherine E Lobel-Rice; Eric A Horne; Mark L Dell'Acqua; Gary L Johnson
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.
Nature cell biology 2003;5(12):1104-10.
2003: Xudong Wei; Weiyong Sun; Ruihua Fan; Joanne Hahn; Anthony Joetham; Guiming Li; Saiphone Webb; Timothy Garrington; Azzeddine Dakhama; Joseph Lucas; Gary L Johnson; Erwin W Gelfand
MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells.
European journal of immunology 2003;33(10):2903-9.
2003: Kazuhiro Nakamura; Gary L Johnson
PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.
The Journal of biological chemistry 2003;278(39):36989-92.
2003: Roberta L DeBiasi; Penny Clarke; Suzanne M Meintzer; Robert Jotte; Bette K Kleinschmidt-DeMasters; Gary L Johnson; Kenneth L Tyler
Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis.
Journal of virology 2003;77(16):8934-47.
2003: Bruce D Cuevas; Amy N Abell; James A Witowsky; Toshiaki Yujiri; Nancy L Johnson; Kamala Kesavan; Marti Ware; Peter Lloyd Jones; Scott A Weed; Roberta L DeBiasi; Yoshitomo Oka; Kenneth L Tyler; Gary L Johnson
MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.
The EMBO journal 2003;22(13):3346-55.
2003: Weiyong Sun; Xudong Wei; Kamala Kesavan; Timothy P Garrington; Ruihua Fan; Junjie Mei; Steven M Anderson; Erwin W Gelfand; Gary L Johnson
MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src.
Molecular and cellular biology 2003;23(7):2298-308.
2003: James A Witowsky; Amy N Abell; Nancy L Johnson; Gary L Johnson; Bruce D Cuevas
MEKK1 is required for inducible urokinase-type plasminogen activator expression.
The Journal of biological chemistry 2003;278(8):5941-6.
2003: James A Witowsky; Gary L Johnson
Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways.
The Journal of biological chemistry 2003;278(3):1403-6.
2002: Gary L Johnson; Razvan Lapadat
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.
Science (New York, N.Y.) 2002;298(5600):1911-2.
2002: Andrea Bild; Francisco J Mendoza; Erika M Gibson; Mei Huang; Jacylyn Villanueva; Timothy P Garrington; Richard Jove; Gary L Johnson; Spencer B Gibson
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage.
Oncogene 2002;21(43):6649-56.
2002: Kathleen A Gallo; Gary L Johnson
Mixed-lineage kinase control of JNK and p38 MAPK pathways.
Nature reviews. Molecular cell biology 2002;3(9):663-72.
2002: Michio Sugita; Mark W Geraci; Bifeng Gao; Roger L Powell; Fred R Hirsch; Gary L Johnson; Razvan Lapadat; Edward Gabrielson; Roy M Bremnes; Paul A Bunn; Wilbur A Franklin
Combined use of oligonucleotide and tissue microarrays identifies cancer/testis antigens as biomarkers in lung carcinoma.
Cancer research 2002;62(14):3971-9.
2002: C Kenneth Kassenbrock; Seija Hunter; Pamela Garl; Gary L Johnson; Steven M Anderson
Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.
The Journal of biological chemistry 2002;277(28):24967-75.
2002: Junichi Sadoshima; Olivier Montagne; Qian Wang; Guiping Yang; Jill Warden; Jing Liu; Gen Takagi; Vijaya Karoor; Chull Hong; Gary L Johnson; Dorothy E Vatner; Stephen F Vatner
The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.
The Journal of clinical investigation 2002;110(2):271-9.
2002: Daniel Chan; Lajos Gera; John Stewart; Barbara Helfrich; Marileila Verella-Garcia; Gary L Johnson; Anna Baron; Jie Yang; Theodore Puck; Paul A Bunn
Bradykinin antagonist dimer, CU201, inhibits the growth of human lung cancer cell lines by a "biased agonist" mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4608-13.
2002: Thomas Schlesinger; Christelle Bonvin; Matthew B Jarpe; Gary R Fanger; Jean-René Cardinaux; Gary L Johnson; Christian Widmann
Apoptosis stimulated by the 91-kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments.
The Journal of biological chemistry 2002;277(12):10283-91.
2002: Tetsuo Minamino; Toshiaki Yujiri; Naohiro Terada; George E Taffet; Lloyd H Michael; Gary L Johnson; Michael D Schneider
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3866-71.
2002: George J Poggioli; Roberta L DeBiasi; Ryan J Bickel; Robert Jotte; Aaron C Spalding; Gary L Johnson; Kenneth L Tyler
Reovirus-induced alterations in gene expression related to cell cycle regulation.
Journal of virology 2002;76(6):2585-94.
2002: Gary L Johnson
Signal transduction. Scaffolding proteins--more than meets the eye.
Science (New York, N.Y.) 2002;295(5558):1249-50.
2002: Christelle Bonvin; Audrey Guillon; Miguel X van Bemmelen; Pär Gerwins; Gary L Johnson; Christian Widmann
Role of the amino-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis.
Cellular signalling 2002;14(2):123-31.
2002: Aaron C Spalding; Robert M Jotte; Robert I Scheinman; Mark W Geraci; Penny Clarke; Kenneth L Tyler; Gary L Johnson
TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells.
Oncogene 2002;21(2):260-71.
2001: Penny Clarke; Suzanne M Meintzer; C Widmann; Gary L Johnson; Kenneth L Tyler
Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun.
Journal of virology 2001;75(23):11275-83.
2001: Penny Clarke; Suzanne M Meintzer; Aaron C Spalding; Gary L Johnson; Kenneth L Tyler
Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection.
Oncogene 2001;20(47):6910-9.
2001: Christian Widmann; Susan Sather; R Oyer; Gary L Johnson; S C Dreskin
In vitro activity of MEKK2 and MEKK3 in detergents is a function of a valine to serine difference in the catalytic domain.
Biochimica et biophysica acta 2001;1547(1):167-73.
2001: K Chayama; PJ Papst; Timothy P Garrington; JC Pratt; T Ishizuka; Saiphone Webb; S Ganiatsas; L I Zon; Weiyong Sun; Gary L Johnson; Erwin W Gelfand
Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4599-604.
2001: Weiyong Sun; Kamala Kesavan; B C Schaefer; Timothy P Garrington; Marti Ware; Nancy L Johnson; Erwin W Gelfand; Gary L Johnson
MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.
The Journal of biological chemistry 2001;276(7):5093-100.
2001: Natalie J Avdi; Jerry A Nick; Ben B Whitlock; MA Billstrom; Peter M Henson; Gary L Johnson; G Scott Worthen
Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis.
The Journal of biological chemistry 2001;276(3):2189-99.
2000: Timothy P Garrington; T Ishizuka; PJ Papst; K Chayama; Saiphone Webb; Toshiaki Yujiri; Weiyong Sun; Susan Sather; D M Russell; Spencer B Gibson; G Keller; Erwin W Gelfand; Gary L Johnson
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells.
The EMBO journal 2000;19(20):5387-95.
2000: Penny Clarke; Suzanne M Meintzer; S Gibson; C Widmann; Timothy P Garrington; Gary L Johnson; Kenneth L Tyler
Reovirus-induced apoptosis is mediated by TRAIL.
Journal of virology 2000;74(17):8135-9.
2000: Weiyong Sun; S Vincent; J Settleman; Gary L Johnson
MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase.
The Journal of biological chemistry 2000;275(32):24421-8.
2000: Surender Kharbanda; Pramod Pandey; T Yamauchi; S Kumar; M Kaneki; V Kumar; Ajit Bharti; Zhi-Min Yuan; L Ghanem; Ajay Rana; Ralph Weichselbaum; Gary L Johnson; Donald Kufe
Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage.
Molecular and cellular biology 2000;20(14):4979-89.
2000: Toshiaki Yujiri; Marti Ware; Christian Widmann; R Oyer; D Russell; E Chan; Yuzuru Zaitsu; P Clarke; K Tyler; Yoshitomo Oka; Gary R Fanger; P Henson; Gary L Johnson
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7272-7.
2000: N Sakata; Eckard H Hamelmann; Anthony W Siadak; N Terada; Pär Gerwins; Alejandro Aruffo; Gary L Johnson; Erwin W Gelfand
Differential regulation of CD40-mediated human B cell responses by antibodies directed against different CD40 epitopes.
Cellular immunology 2000;201(2):109-23.
2000: Daniel R Ambruso; Cindy Knall; Amy N Abell; J Panepinto; Arlet G Kurkchubasche; Gail Thurman; Carolina Gonzalez-Aller; Andrew A Hiester; M deBoer; Ronald J Harbeck; R Oyer; Gary L Johnson; D Roos
Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4654-9.
2000: N Sakata; H Kawasome; N Terada; Gary L Johnson; Erwin W Gelfand
CD40 and adenosine A2 receptor agonist-cyclic adenosine monophosphate rescue B-cell antigen receptor-induced apoptosis through independent pathways and converge to prevent caspase activation.
The Journal of allergy and clinical immunology 2000;105(3):522-31.
2000: S B Gibson; R Oyer; A C Spalding; S M Anderson; Gary L Johnson
Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL.
Molecular and cellular biology 2000;20(1):205-12.
1999: Tetsuo Minamino; Toshiaki Yujiri; PJ Papst; Edward D Chan; Gary L Johnson; N Terada
MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15127-32.
1999: Thomas Schlesinger; Kris A DeMali; Gary L Johnson; Andrius Kazlauskas
Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src.
The Biochemical journal 1999;344 Pt 2():519-26.
1999: Brian C Schaefer; Marti Ware; Philippa Marrack; Gary R Fanger; John W Kappler; Gary L Johnson; CR Monks
Live cell fluorescence imaging of T cell MEKK2: redistribution and activation in response to antigen stimulation of the T cell receptor.
Immunity 1999;11(4):411-21.
1999: N Sakata; H Kawasome; N Terada; Pär Gerwins; Gary L Johnson; Erwin W Gelfand
Differential activation and regulation of mitogen-activated protein kinases through the antigen receptor and CD40 in human B cells.
European journal of immunology 1999;29(9):2999-3008.
1999: Jerry A Nick; Natalie J Avdi; Scott K Young; PP McDonald; MA Billstrom; Peter M Henson; Gary L Johnson; G Scott Worthen
An intracellular signaling pathway linking lipopolysaccharide stimulation to cellular responses of the human neutrophil: the p38 MAP kinase cascade and its functional significance.
Chest 1999;116(1 Suppl):54S-55S.
1999: S Gibson; S Tu; R Oyer; S M Anderson; Gary L Johnson
Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation.
The Journal of biological chemistry 1999;274(25):17612-8.
1999: Toshiaki Yujiri; Gary R Fanger; Timothy P Garrington; Thomas Schlesinger; S Gibson; Gary L Johnson
MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton.
The Journal of biological chemistry 1999;274(18):12605-10.
1999: S Gibson; Christian Widmann; Gary L Johnson
Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents.
The Journal of biological chemistry 1999;274(16):10916-22.
1999: Timothy P Garrington; Gary L Johnson
Organization and regulation of mitogen-activated protein kinase signaling pathways.
Current opinion in cell biology 1999;11(2):211-8.
1999: Jerry A Nick; Natalie J Avdi; Scott K Young; Lisa Lehman; PP McDonald; S Courtney Frasch; MA Billstrom; Peter M Henson; Gary L Johnson; G Scott Worthen
Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils.
The Journal of clinical investigation 1999;103(6):851-8.
1999: T Ishizuka; K Chayama; Katsuyuki Takeda; Eckard H Hamelmann; N Terada; Gordon M Keller; Gary L Johnson; Erwin W Gelfand
Mitogen-activated protein kinase activation through Fc epsilon receptor I and stem cell factor receptor is differentially regulated by phosphatidylinositol 3-kinase and calcineurin in mouse bone marrow-derived mast cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2087-94.
1999: Christian Widmann; S Gibson; Matthew B Jarpe; Gary L Johnson
Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
Physiological reviews 1999;79(1):143-80.
1998: Toshiaki Yujiri; Susan Sather; Gary R Fanger; Gary L Johnson
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.
Science (New York, N.Y.) 1998;282(5395):1911-4.
1998: Thomas Schlesinger; Gary R Fanger; Toshiaki Yujiri; Gary L Johnson
The TAO of MEKK.
Frontiers in bioscience : a journal and virtual library 1998;3():D1181-6.
1998: Kenneth R McLeish; C Knall; Richard A Ward; P Gerwins; Patricia Y Coxon; Klein Jon; Gary L Johnson
Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-alpha and GM-CSF.
Journal of leukocyte biology 1998;64(4):537-45.
1998: T Ishizuka; H Kawasome; N Terada; Katsuyuki Takeda; Pär Gerwins; Gordon M Keller; Gary L Johnson; Erwin W Gelfand
Stem cell factor augments Fc epsilon RI-mediated TNF-alpha production and stimulates MAP kinases via a different pathway in MC/9 mast cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3624-30.
1998: Matthew B Jarpe; Christian Widmann; C Knall; Thomas Schlesinger; S Gibson; Toshiaki Yujiri; Gary R Fanger; Erwin W Gelfand; Gary L Johnson
Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death.
Oncogene 1998;17(11 Reviews):1475-82.
1998: MA Billstrom; Gary L Johnson; Natalie J Avdi; G Scott Worthen
Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection.
Journal of virology 1998;72(7):5535-44.
1998: H Kawasome; PJ Papst; Saiphone Webb; Gordon M Keller; Gary L Johnson; Erwin W Gelfand; N Terada
Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5033-8.
1998: Christian Widmann; Pär Gerwins; N L Johnson; Matthew B Jarpe; Gary L Johnson
MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis.
Molecular and cellular biology 1998;18(4):2416-29.
1998: Christian Widmann; S Gibson; Gary L Johnson
Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals.
The Journal of biological chemistry 1998;273(12):7141-7.
1998: Gary R Fanger; Christian Widmann; Amy C Porter; Susan Sather; Gary L Johnson; Richard R Vaillancourt
14-3-3 proteins interact with specific MEK kinases.
The Journal of biological chemistry 1998;273(6):3476-83.
1998: Matthew B Jarpe; C Knall; F M Mitchell; A M Buhl; E Duzic; Gary L Johnson
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors.
The Journal of biological chemistry 1998;273(5):3097-104.
1998: C Knall; Gary L Johnson
G-protein regulatory pathways: rocketing into the twenty-first century.
Journal of cellular biochemistry. Supplement 1998;30-31():137-46.
1997: Christian Widmann; N L Johnson; A M Gardner; R J Smith; Gary L Johnson
Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1.
Oncogene 1997;15(20):2439-47.
1997: BW Winston; Edward D Chan; Gary L Johnson; David W H Riches
Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4491-7.
1997: Gary R Fanger; N L Johnson; Gary L Johnson
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42.
The EMBO journal 1997;16(16):4961-72.
1997: T Ishizuka; N Terada; Pär Gerwins; Eckard H Hamelmann; A Oshiba; Gary R Fanger; Gary L Johnson; Erwin W Gelfand
Mast cell tumor necrosis factor alpha production is regulated by MEK kinases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6358-63.
1997: DM Rose; BW Winston; Edward D Chan; David W H Riches; Pär Gerwins; Gary L Johnson; Peter M Henson
Fc gamma receptor cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3433-8.
1997: Gary L Johnson
Signal transduction abnormalities in cancer mitogen-activated protein kinase regulation is altered in breast cancer.
The Journal of clinical investigation 1997;99(7):1463-4.
1997: C Knall; G Scott Worthen; Gary L Johnson
Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3052-7.
1997: Pär Gerwins; J L Blank; Gary L Johnson
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway.
The Journal of biological chemistry 1997;272(13):8288-95.
1997: Jerry A Nick; Natalie J Avdi; Scott K Young; C Knall; P Gerwins; Gary L Johnson; G Scott Worthen
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.
The Journal of clinical investigation 1997;99(5):975-86.
1997: Gary R Fanger; Pär Gerwins; Christian Widmann; Matthew B Jarpe; Gary L Johnson
MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?
Current opinion in genetics & development 1997;7(1):67-74.
1997: T Ishizuka; N Sakata; Gary L Johnson; Erwin W Gelfand; N Terada
Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells.
Biochemical and biophysical research communications 1997;230(2):386-91.
1997: Gary R Fanger; Richard R Vaillancourt; Lynn E Heasley; J P Montmayeur; Gary L Johnson; Robert A Maue
Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation.
Molecular and cellular biology 1997;17(1):89-99.
1996: Natalie J Avdi; BW Winston; M Russel; Scott K Young; Gary L Johnson; G Scott Worthen
Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation.
The Journal of biological chemistry 1996;271(52):33598-606.
1996: Richard R Vaillancourt; A M Gardner; Andrius Kazlauskas; Gary L Johnson
The kinase-inactive PDGF beta-receptor mediates activation of the MAP kinase cascade via the endogenous PDGF alpha-receptor in HepG2 cells.
Oncogene 1996;13(1):151-9.
1996: Jerry A Nick; Natalie J Avdi; P Gerwins; Gary L Johnson; G Scott Worthen
Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4867-75.
1996: A M Gardner; Gary L Johnson
Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase.
The Journal of biological chemistry 1996;271(24):14560-6.
1996: T Ishizuka; A Oshiba; N Sakata; N Terada; Gary L Johnson; Erwin W Gelfand
Aggregation of the FcepsilonRI on mast cells stimulates c-Jun amino-terminal kinase activity. A response inhibited by wortmannin.
The Journal of biological chemistry 1996;271(22):12762-6.
1996: J L Blank; Pär Gerwins; E M Elliott; S Sather; Gary L Johnson
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase.
The Journal of biological chemistry 1996;271(10):5361-8.
1996: N L Johnson; A M Gardner; K M Diener; C A Lange-Carter; J Gleavy; Matthew B Jarpe; Audrey Minden; Michael Karin; L I Zon; Gary L Johnson
Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death.
The Journal of biological chemistry 1996;271(6):3229-37.
1996: C Knall; S Young; Jerry A Nick; A M Buhl; G Scott Worthen; Gary L Johnson
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
The Journal of biological chemistry 1996;271(5):2832-8.
1996: Lynn E Heasley; J Zamarripa; B Storey; Barbara Helfrich; F M Mitchell; Paul A Bunn; Gary L Johnson
Discordant signal transduction and growth inhibition of small cell lung carcinomas induced by expression of GTPase-deficient G alpha 16.
The Journal of biological chemistry 1996;271(1):349-54.
1995: N Sakata; H R Patel; N Terada; A Aruffo; Gary L Johnson; Erwin W Gelfand
Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells.
The Journal of biological chemistry 1995;270(51):30823-8.
1995: A M Buhl; N L Johnson; N Dhanasekaran; Gary L Johnson
G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly.
The Journal of biological chemistry 1995;270(42):24631-4.
1995: C Knall; G Scott Worthen; A M Buhl; Gary L Johnson
IL-8 signal transduction in human neutrophils.
Annals of the New York Academy of Sciences 1995;766():288-91.
1995: A M Buhl; S Osawa; Gary L Johnson
Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.
The Journal of biological chemistry 1995;270(34):19828-32.
1995: M V Prasad; Jonathan M Dermott; Lynn E Heasley; Gary L Johnson; N Dhanasekaran
Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13.
The Journal of biological chemistry 1995;270(31):18655-9.
1995: F M Mitchell; M Russell; Gary L Johnson
Differential calcium dependence in the activation of c-Jun kinase and mitogen-activated protein kinase by muscarinic acetylcholine receptors in rat 1a cells.
The Biochemical journal 1995;309 ( Pt 2)():381-4.
1995: Richard R Vaillancourt; Lynn E Heasley; J Zamarripa; B Storey; M Valius; Andrius Kazlauskas; Gary L Johnson
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation.
Molecular and cellular biology 1995;15(7):3644-53.
1995: N Dhanasekaran; Lynn E Heasley; Gary L Johnson
G protein-coupled receptor systems involved in cell growth and oncogenesis.
Endocrine reviews 1995;16(3):259-70.
1995: M Russell; C A Lange-Carter; Gary L Johnson
Regulation of recombinant MEK1 and MEK2b expressed in Escherichia coli.
Biochemistry 1995;34(20):6611-5.
1995: M Russell; C A Lange-Carter; Gary L Johnson
Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1).
The Journal of biological chemistry 1995;270(20):11757-60.
1995: A Lin; Audrey Minden; H Martinetto; Francois Claret; C Lange-Carter; F Mercurio; Gary L Johnson; Michael Karin
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
Science (New York, N.Y.) 1995;268(5208):286-90.
1995: F M Mitchell; Lynn E Heasley; N X Qian; J Zamarripa; Gary L Johnson
Differential modulation of bombesin-stimulated phospholipase C beta and mitogen-activated protein kinase activity by [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P.
The Journal of biological chemistry 1995;270(15):8623-8.
1995: BW Winston; C A Lange-Carter; A M Gardner; Gary L Johnson; David W H Riches
Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1614-8.
1995: N X Qian; M Russell; Gary L Johnson
Acetylcholine muscarinic receptor regulation of the Ras/Raf/MAP kinase pathway.
Life sciences 1995;56(11-12):945-9.
1995: C A Lange-Carter; Gary L Johnson
Assay of MEK kinases.
Methods in enzymology 1995;255():290-301.
1994: Audrey Minden; A Lin; M McMahon; C Lange-Carter; B Dérijard; Roger J Davis; Gary L Johnson; Michael Karin
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.
Science (New York, N.Y.) 1994;266(5191):1719-23.
1994: Richard R Vaillancourt; A M Gardner; Gary L Johnson
B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.
Molecular and cellular biology 1994;14(10):6522-30.
1994: F Goldman; W A Jensen; Gary L Johnson; L Heasley; John C Cambier
gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):2905-17.
1994: A M Buhl; Natalie J Avdi; G Scott Worthen; Gary L Johnson
Mapping of the C5a receptor signal transduction network in human neutrophils.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):9190-4.
1994: C A Lange-Carter; Gary L Johnson
Ras-dependent growth factor regulation of MEK kinase in PC12 cells.
Science (New York, N.Y.) 1994;265(5177):1458-61.
1994: G Scott Worthen; Natalie J Avdi; A M Buhl; N Suzuki; Gary L Johnson
FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.
The Journal of clinical investigation 1994;94(2):815-23.
1994: N X Qian; M Russell; A M Buhl; Gary L Johnson
Expression of GTPase-deficient G alpha 16 inhibits Swiss 3T3 cell growth.
The Journal of biological chemistry 1994;269(26):17417-23.
1994: Kendall J Blumer; Gary L Johnson
Diversity in function and regulation of MAP kinase pathways.
Trends in biochemical sciences 1994;19(6):236-40.
1994: Kendall J Blumer; Gary L Johnson; C A Lange-Carter
Mammalian mitogen-activated protein kinase kinase kinase (MEKK) can function in a yeast mitogen-activated protein kinase pathway downstream of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4925-9.
1994: R A Franklin; A Tordai; H Patel; A M Gardner; Gary L Johnson; Erwin W Gelfand
Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.
The Journal of clinical investigation 1994;93(5):2134-40.
1994: M Russell; S Winitz; Gary L Johnson
Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity.
Molecular and cellular biology 1994;14(4):2343-51.
1994: Gary L Johnson; Richard R Vaillancourt
Sequential protein kinase reactions controlling cell growth and differentiation.
Current opinion in cell biology 1994;6(2):230-8.
1994: Gary L Johnson; A M Gardner; C Lange-Carter; N X Qian; M Russell; S Winitz
How does the G protein, Gi2, transduce mitogenic signals?
Journal of cellular biochemistry 1994;54(4):415-22.
1994: A Tordai; R A Franklin; H Patel; A M Gardner; Gary L Johnson; Erwin W Gelfand
Cross-linking of surface IgM stimulates the Ras/Raf-1/MEK/MAPK cascade in human B lymphocytes.
The Journal of biological chemistry 1994;269(10):7538-43.
1994: K E Conrad; J M Oberwetter; R Vaillancourt; Gary L Johnson; Arthur Gutierrez-Hartmann
Identification of the functional components of the Ras signaling pathway regulating pituitary cell-specific gene expression.
Molecular and cellular biology 1994;14(3):1553-65.
1994: A M Gardner; Richard R Vaillancourt; C A Lange-Carter; Gary L Johnson
MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity.
Molecular biology of the cell 1994;5(2):193-201.
1994: S Winitz; S K Gupta; N X Qian; Lynn E Heasley; Raphael A Nemenoff; Gary L Johnson
Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.
The Journal of biological chemistry 1994;269(3):1889-95.
1994: C A Lange-Carter; C Pleiman; Gary L Johnson
A novel upstream activator in the mitogen-activated protein kinase signal transduction pathway.
Recent progress in hormone research 1994;49():341-5.
1994: S Winitz; M Russell; Gary L Johnson
Construction of mutant and chimeric G-protein alpha subunits.
Methods in enzymology 1994;237():321-6.
1994: A M Gardner; C A Lange-Carter; Richard R Vaillancourt; Gary L Johnson
Measuring activation of kinases in mitogen-activated protein kinase regulatory network.
Methods in enzymology 1994;238():258-70.
1993: S Winitz; M Russell; N X Qian; A Gardner; L Dwyer; Gary L Johnson
Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.
The Journal of biological chemistry 1993;268(26):19196-9.
1993: C M Pleiman; M R Clark; L K Gauen; S Winitz; K M Coggeshall; Gary L Johnson; Andrey S Shaw; John C Cambier
Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.
Molecular and cellular biology 1993;13(9):5877-87.
1993: A M Gardner; Richard R Vaillancourt; Gary L Johnson
Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.
The Journal of biological chemistry 1993;268(24):17896-901.
1993: M Russell; Gary L Johnson
G protein amino-terminal alpha i2/alpha s chimeras reveal amino acids important in regulating alpha s activity.
Molecular pharmacology 1993;44(2):255-63.
1993: S I Senkfor; Gary L Johnson; Tomas Berl
A molecular map of G protein alpha chains in microdissected rat nephron segments.
The Journal of clinical investigation 1993;92(2):786-90.
1993: A M Buhl; B J Eisfelder; G Scott Worthen; Gary L Johnson; M Russell
Selective coupling of the human anaphylatoxin C5a receptor and alpha 16 in human kidney 293 cells.
FEBS letters 1993;323(1-2):132-4.
1993: B E Wadzinski; W H Wheat; S Jaspers; Leonard Peruski; R L Lickteig; Gary L Johnson; Dwight J Klemm
Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.
Molecular and cellular biology 1993;13(5):2822-34.
1993: N X Qian; S Winitz; Gary L Johnson
Epitope-tagged Gq alpha subunits: expression of GTPase-deficient alpha subunits persistently stimulates phosphatidylinositol-specific phospholipase C but not mitogen-activated protein kinase activity regulated by the M1 muscarinic acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4077-81.
1993: C A Lange-Carter; C M Pleiman; A M Gardner; Kendall J Blumer; Gary L Johnson
A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf.
Science (New York, N.Y.) 1993;260(5106):315-9.
1993: Raphael A Nemenoff; S Winitz; N X Qian; Vicki Van Putten; Gary L Johnson; Lynn E Heasley
Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.
The Journal of biological chemistry 1993;268(3):1960-4.
1992: H A Abdel-Hafiz; Lynn E Heasley; John Kyriakis; J Avruch; David Kroll; Gary L Johnson; J P Hoeffler
Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases.
Molecular endocrinology (Baltimore, Md.) 1992;6(12):2079-89.
1992: C Gallego; S K Gupta; S Winitz; B J Eisfelder; Gary L Johnson
Myristoylation of the G alpha i2 polypeptide, a G protein alpha subunit, is required for its signaling and transformation functions.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9695-9.
1992: B E Wadzinski; B J Eisfelder; Leonard Peruski; M C Mumby; Gary L Johnson
NH2-terminal modification of the phosphatase 2A catalytic subunit allows functional expression in mammalian cells.
The Journal of biological chemistry 1992;267(24):16883-8.
1992: C Gallego; S K Gupta; Lynn E Heasley; N X Qian; Gary L Johnson
Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7355-9.
1992: Lynn E Heasley; Gary L Johnson
The beta-PDGF receptor induces neuronal differentiation of PC12 cells.
Molecular biology of the cell 1992;3(5):545-53.
1992: S K Gupta; C Gallego; Gary L Johnson; Lynn E Heasley
MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.
The Journal of biological chemistry 1992;267(12):7987-90.
1992: S K Gupta; C Gallego; J M Lowndes; C M Pleiman; C Sable; B J Eisfelder; Gary L Johnson
Analysis of the fibroblast transformation potential of GTPase-deficient gip2 oncogenes.
Molecular and cellular biology 1992;12(1):190-7.
1992: S K Gupta; C Gallego; Gary L Johnson
Mitogenic pathways regulated by G protein oncogenes.
Molecular biology of the cell 1992;3(1):123-8.
1991: N Dhanasekaran; S Osawa; Gary L Johnson
The NH2-terminal alpha subunit attenuator domain confers regulation of G protein activation by beta gamma complexes.
Journal of cellular biochemistry 1991;47(4):352-8.
1991: S K Gupta; N Dhanasekaran; Lynn E Heasley; Gary L Johnson
Activating mutations in the NH2- and COOH-terminal moieties of the Gs alpha subunit have dominant phenotypes and distinguishable kinetics of adenylyl cyclase stimulation.
Journal of cellular biochemistry 1991;47(4):359-68.
1991: Gary L Johnson; N Dhanasekaran; S K Gupta; J M Lowndes; R R Vaillancourt; Arnold E Ruoho
Genetic and structural analysis of G protein alpha subunit regulatory domains.
Journal of cellular biochemistry 1991;47(2):136-46.
1991: J M Lowndes; S K Gupta; S Osawa; Gary L Johnson
GTPase-deficient G alpha i2 oncogene gip2 inhibits adenylylcyclase and attenuates receptor-stimulated phospholipase A2 activity.
The Journal of biological chemistry 1991;266(22):14193-7.
1991: Lynn E Heasley; S Benedict; J Gleavy; Gary L Johnson
Requirement of the adenovirus E1A transformation domain 1 for inhibition of PC12 cell neuronal differentiation.
Cell regulation 1991;2(6):479-89.
1991: S Osawa; Gary L Johnson
A dominant negative G alpha s mutant is rescued by secondary mutation of the alpha chain amino terminus.
The Journal of biological chemistry 1991;266(8):4673-6.
1990: B E Wadzinski; Lynn E Heasley; Gary L Johnson
Multiplicity of protein serine-threonine phosphatases in PC12 pheochromocytoma and FTO-2B hepatoma cells.
The Journal of biological chemistry 1990;265(35):21504-8.
1990: S Osawa; N Dhanasekaran; C W Woon; Gary L Johnson
G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions.
Cell 1990;63(4):697-706.
1990: S K Gupta; E Diez; Lynn E Heasley; S Osawa; Gary L Johnson
A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2.
Science (New York, N.Y.) 1990;249(4969):662-6.
1990: S Osawa; Lynn E Heasley; N Dhanasekaran; S K Gupta; C W Woon; C Berlot; Gary L Johnson
Mutation of the Gs protein alpha subunit NH2 terminus relieves an attenuator function, resulting in constitutive adenylyl cyclase stimulation.
Molecular and cellular biology 1990;10(6):2931-40.
1990: R R Vaillancourt; N Dhanasekaran; Gary L Johnson; Arnold E Ruoho
2-Azido-[32P]NAD+, a photoactivatable probe for G-protein structure: evidence for holotransducin oligomers in which the ADP-ribosylated carboxyl terminus of alpha interacts with both alpha and gamma subunits.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3645-9.
1990: Daniel J Kelleher; Gary L Johnson
Characterization of rhodopsin kinase purified from bovine rod outer segments.
The Journal of biological chemistry 1990;265(5):2632-9.
1990: Ellen R Weiss; R A Heller-Harrison; E Diez; M Crasnier; C C Malbon; Gary L Johnson
Rhodopsin expressed in Chinese hamster ovary cells regulates adenylyl cyclase activity.
Journal of molecular endocrinology 1990;4(1):71-9.
1990: Lynn E Heasley; N Dhanasekaran; S K Gupta; S Osawa; Gary L Johnson
Chimeras of the Gs alpha subunit that had the NH2- or COOH-terminal sequence substituted for the corresponding region of the Gi alpha subunit constitutively activate adenylyl cyclase.
Society of General Physiologists series 1990;45():117-24.
1989: Gary L Johnson; N Dhanasekaran
The G-protein family and their interaction with receptors.
Endocrine reviews 1989;10(3):317-31.
1989: C W Woon; Lynn E Heasley; S Osawa; Gary L Johnson
Mutation of glycine 49 to valine in the alpha subunit of GS results in the constitutive elevation of cyclic AMP synthesis.
Biochemistry 1989;28(11):4547-51.
1989: L E Heasley; Gary L Johnson
Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells.
The Journal of biological chemistry 1989;264(15):8646-52.
1989: C W Woon; S Soparkar; Lynn E Heasley; Gary L Johnson
Expression of a G alpha s/G alpha i chimera that constitutively activates cyclic AMP synthesis.
The Journal of biological chemistry 1989;264(10):5687-93.
1989: M Wessling-Resnick; Gary L Johnson
Evidence for oligomeric forms of transducins alpha subunit: formation of intermolecular alpha-alpha disulfide linkages.
Biochemical and biophysical research communications 1989;159(2):651-7.
1989: L E Heasley; Gary L Johnson
Detection of nerve growth factor and epidermal growth factor-regulated protein kinases in PC12 cells with synthetic peptide substrates.
Molecular pharmacology 1989;35(3):331-8.
1989: S R Jaspers; J Rulfs; Gary L Johnson; J E Mole; T B Miller
Amino-terminal sequence analysis of rat heart and muscle glycogen synthase: homology to the rabbit enzyme and the implications for hormonal control.
Archives of biochemistry and biophysics 1989;268(2):630-6.
1988: N Dhanasekaran; M Wessling-Resnick; D J Kelleher; Gary L Johnson; Arnold E Ruoho
Mapping of the carboxyl terminus within the tertiary structure of transducin's alpha subunit using the heterobifunctional cross-linking reagent, 125I-N-(3-iodo-4-azidophenylpropionamido-S-(2-thiopyridyl) cysteine.
The Journal of biological chemistry 1988;263(34):17942-50.
1988: Ellen R Weiss; Daniel J Kelleher; C W Woon; S Soparkar; S Osawa; Lynn E Heasley; Gary L Johnson
Receptor activation of G proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(13):2841-8.
1988: Daniel J Kelleher; Gary L Johnson
Transducin inhibition of light-dependent rhodopsin phosphorylation: evidence for beta gamma subunit interaction with rhodopsin.
Molecular pharmacology 1988;34(4):452-60.
1988: J Arino; C W Woon; D L Brautigan; T B Miller; Gary L Johnson
Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4252-6.
1988: Ellen R Weiss; Daniel J Kelleher; Gary L Johnson
Mapping sites of interaction between rhodopsin and transducin using rhodopsin antipeptide antibodies.
The Journal of biological chemistry 1988;263(13):6150-4.
1987: Gary L Johnson; D L Brautigan; C Shriner; S Jaspers; J Arino; J E Mole; T B Miller; M C Mumby
Sequence homologies between type 1 and type 2A protein phosphatases.
Molecular endocrinology (Baltimore, Md.) 1987;1(10):745-8.
1987: M Wessling-Resnick; Gary L Johnson
Kinetic and hydrodynamic properties of transducin: comparison of physical and structural parameters for GTP-binding regulatory proteins.
Biochemistry 1987;26(14):4316-23.
1987: C D Wolleben; R K McPherson; J Rulfs; Gary L Johnson; T B Miller
Phosphorylation of rat heart glycogen synthase: studies in cardiomyocytes and in vitro phosphorylations with cAMP-dependent kinase and protein phosphatase-1.
Biochimica et biophysica acta 1987;928(1):98-106.
1987: Ellen R Weiss; J R Hadcock; Gary L Johnson; C C Malbon
Antipeptide antibodies directed against cytoplasmic rhodopsin sequences recognize the beta-adrenergic receptor.
The Journal of biological chemistry 1987;262(9):4319-23.
1986: R J Davis; Gary L Johnson; D J Kelleher; J K Anderson; J E Mole; Michael P Czech
Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.
The Journal of biological chemistry 1986;261(19):9034-41.
1985: J Rulfs; C D Wolleben; T B Miller; Gary L Johnson
Immunologic identification of a glycogen synthase 93,000-dalton subunit from rat heart and liver.
The Journal of biological chemistry 1985;260(2):1203-7.
1984: D J Kelleher; Jeffrey Pessin; Arnold E Ruoho; Gary L Johnson
Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(14):4316-20.
1983: D J Kelleher; A Rashidbaigi; Arnold E Ruoho; Gary L Johnson
Rapid vesicle reconstitution of alprenolol-Sepharose-purified beta 1-adrenergic receptors. Interaction of the purified receptor with N.
The Journal of biological chemistry 1983;258(21):12881-5.
1980: H R Kaslow; Gary L Johnson; V M Brothers; H R Bourne
A regulatory component of adenylate cyclase from human erythrocyte membranes.
The Journal of biological chemistry 1980;255(8):3736-41.
1979: H R Kaslow; Z Farfel; Gary L Johnson; H R Bourne
Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate.
Molecular pharmacology 1979;15(3):472-83.
1979: Gary L Johnson; H R Bourne; M K Gleason; Philip Coffino; P A Insel; K L Melmon
Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase.
Molecular pharmacology 1979;15(1):16-27.
1978: Gary L Johnson; H R Kaslow; H R Bourne
Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.
The Journal of biological chemistry 1978;253(20):7120-3.
1978: Gary L Johnson; H R Kaslow; H R Bourne
Reconstitution of cholera toxin-activated adenylate cyclase.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(7):3113-7.
1978: J Naya-Vigne; Gary L Johnson; H R Bourne; Philip Coffino
Complementation analysis of hormone-sensitive adenylate cyclase.
Nature 1978;272(5655):720-2.
1977: Gary L Johnson; H R Bourne
Influence of cholera toxin on the regulation of adenylate cyclase by GTP.
Biochemical and biophysical research communications 1977;78(2):792-8.