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James Johnson

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Islets of Langerhans Transplantation

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TOP 3
G E Lim; M Piske; James D Johnson
14-3-3 proteins are essential signalling hubs for beta cell survival.
Arya E Mehran; Nicole M Templeman; Timothy J Kieffer; Gareth E Lim; Ali Asadi; shernaz bamji; Jose Diego Botezelli; G Stefano Brigidi; Kwan Yi Chu; Susanne M Clee; Bradford G Hoffman; Xiaoke Hu; James D Johnson
Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.
Michael J Bround; Michael F Allard; Parisa Asghari; Kenneth R Boheler; Lubos Bohunek; Timothy J Kieffer; Edward G Lakatta; Edwin D W Moore; Marjolaine Philit; Claire Smits; Richard B Wambolt; James D Johnson
Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice.

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All Publications

2013: G E Lim; M Piske; James D Johnson
14-3-3 proteins are essential signalling hubs for beta cell survival.
Diabetologia 2013;56(4):825-37.
2012: Arya E Mehran; Nicole M Templeman; Timothy J Kieffer; Gareth E Lim; Ali Asadi; shernaz bamji; Jose Diego Botezelli; G Stefano Brigidi; Kwan Yi Chu; Susanne M Clee; Bradford G Hoffman; Xiaoke Hu; James D Johnson
Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.
Cell metabolism 2012;16(6):723-37.
2012: Michael J Bround; Michael F Allard; Parisa Asghari; Kenneth R Boheler; Lubos Bohunek; Timothy J Kieffer; Edward G Lakatta; Edwin D W Moore; Marjolaine Philit; Claire Smits; Richard B Wambolt; James D Johnson
Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice.
Cardiovascular research 2012;96(3):372-80.
2012: Fang Wang; Ying Wang; Dahai Zhang; James D Johnson; Prasanth Puthanveetil; Brian Rodrigues
Fatty acid-induced nuclear translocation of heparanase uncouples glucose metabolism in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):406-14.
2012: James D Johnson; Michael J Bround; Sarah A White; Dan S Luciani
Nanospaces between endoplasmic reticulum and mitochondria as control centres of pancreatic β-cell metabolism and survival.
Protoplasma 2012;249 Suppl 1():S49-58.
2012: Corinne A Hoesli; James D Johnson; James M Piret
Purified human pancreatic duct cell culture conditions defined by serum-free high-content growth factor screening.
PloS one 2012;7(3):e33999.
2012: K Y Chu; H Li; K Wada; James D Johnson
Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions.
Diabetologia 2012;55(1):128-40.
2011: Emilyn Alejandro; Manuela Baccarini; Xiaoke Hu; Gareth E Lim; Arya E Mehran; Dmytro Pelipeychenko; Farnaz Taghizadeh; James D Johnson
Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(11):3884-95.
2011: Marta Szabat; C Bruce Verchere; Garth L Warnock; James M Piret; Poya Pourghaderi; Galina Soukhatcheva; James D Johnson
Kinetics and genomic profiling of adult human and mouse β-cell maturation.
Islets 2011;3(4):175-87.
2011: Kwan Yi Chu; Peter F Drain; Tobias Albrecht; Meredith J L Briggs; James D Johnson
Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells.
Islets 2011;3(4):155-65.
2011: M Fu; L Li; T Albrecht; James D Johnson; Luba Kojic; Ivan R Nabi
Autocrine motility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release.
Cell death and differentiation 2011;18(6):1057-70.
2011: Y H C Yang; M Szabat; C Bragagnini; K Kott; C D Helgason; B G Hoffman; James D Johnson
Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors.
Diabetologia 2011;54(4):828-42.
2011: Corinne A Hoesli; Kamini Raghuram; Roger L J Kiang; Dušana Mocinecová; Xiaoke Hu; James D Johnson; Igor Lacík; Timothy J Kieffer; James M Piret
Pancreatic cell immobilization in alginate beads produced by emulsion and internal gelation.
Biotechnology and bioengineering 2011;108(2):424-34.
2011: Marco Gallo; Donha Park; Dan S Luciani; Katarzyna Kida; Ferdinando Palmieri; Oliver E Blacque; James D Johnson; Donald L Riddle
MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion.
PloS one 2011;6(3):e17827.
2010: M Szabat; James D Johnson; James M Piret
Reciprocal modulation of adult beta cell maturity by activin A and follistatin.
Diabetologia 2010;53(8):1680-9.
2010: Fang Wang; Ying Wang; Min Suk Kim; Prasanth Puthanveetil; Sanjoy Ghosh; Dan S Luciani; James D Johnson; Ashraf Abrahani; Brian Rodrigues
Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization.
Cardiovascular research 2010;87(1):127-36.
2010: Meredith J H Hutton; Galina Soukhatcheva; James D Johnson; C Bruce Verchere
Role of the TLR signaling molecule TRIF in β-cell function and glucose homeostasis.
Islets 2010;2(2):104-11.
2010: Emilyn Alejandro; Tatyana B Kalynyak; Farnaz Taghizadeh; Kamila S Gwiazda; Erin K Rawstron; Karen J Jacob; James D Johnson
Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways.
Endocrinology 2010;151(2):502-12.
2010: Jessica A Hill; Marta Szabat; Corinne A Hoesli; Blair K Gage; Yu Hsuan C Yang; David E Williams; Michael J Riedel; Dan S Luciani; Tatyana B Kalynyak; Kevin Tsai; Ziliang Ao; Raymond J Andersen; Garth L Warnock; James M Piret; Timothy J Kieffer; James D Johnson
A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression.
PloS one 2010;5(9):e12958.
2010: James D Johnson; Dan S Luciani
Mechanisms of pancreatic beta-cell apoptosis in diabetes and its therapies.
Advances in experimental medicine and biology 2010;654():447-62.
2009: James D Johnson; Kenichi Otani; Graeme I Bell; Kenneth S Polonsky
Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cells.
Islets 2009;1(3):242-8.
2009: Kei Fujimoto; Piia T Hanson; Hung Tran; Eric L Ford; Zhiqiang Han; James D Johnson; Robert E Schmidt; Karen G Green; Burton M Wice; Kenneth S Polonsky
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.
The Journal of biological chemistry 2009;284(40):27664-73.
2009: Girish Kewalramani; Prasanth Puthanveetil; Fang Wang; Min Suk Kim; Sylvia Deppe; Ashraf Abrahani; Dan S Luciani; James D Johnson; Brian Rodrigues
AMP-activated protein kinase confers protection against TNF-{alpha}-induced cardiac cell death.
Cardiovascular research 2009;84(1):42-53.
2009: Marta Szabat; Dan S Luciani; James M Piret; James D Johnson
Maturation of adult beta-cells revealed using a Pdx1/insulin dual-reporter lentivirus.
Endocrinology 2009;150(4):1627-35.
2009: Dan S Luciani; Kamila S Gwiazda; Ting-Lin B Yang; Tatyana B Kalynyak; Yaryna Bychkivska; Matthew H Z Frey; Kristin D Jeffrey; Arthur V Sampaio; Tully Underhill; James D Johnson
Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.
Diabetes 2009;58(2):422-32.
2009: James D Johnson; Ziliang Ao; Peter Ao; Hong Li; Long-Jun Dai; Zehua He; May Tee; Kathryn J Potter; Agnieszka Klimek; R Mark Meloche; David M Thompson; C Bruce Verchere; Garth L Warnock
Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets.
Cell transplantation 2009;18(8):833-45.
2009: James D Johnson
Proteomic identification of carboxypeptidase E connects lipid-induced beta-cell apoptosis and dysfunction in type 2 diabetes.
Cell cycle (Georgetown, Tex.) 2009;8(1):38-42.
2008: Garth L Warnock; David M Thompson; R Mark Meloche; R Jean Shapiro; Ziliang Ao; Paul Keown; James D Johnson; C Bruce Verchere; Nilufar Partovi; Iain S Begg; Michelle Fung; Sharon E Kozak; Suet On Tong; Khalid M Alghofaili; Claire Harris
A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes.
Transplantation 2008;86(12):1762-6.
2008: Yanni Wang; Brandon P H Huang; Dan S Luciani; Xuemin Wang; James D Johnson; Christopher G Proud
Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes.
Journal of molecular and cellular cardiology 2008;45(6):812-20.
2008: Kristin D Jeffrey; Emilyn Alejandro; Dan S Luciani; Tatyana B Kalynyak; Xiaoke Hu; Hong Li; Yalin Lin; R Reid Townsend; Kenneth S Polonsky; James D Johnson
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8452-7.
2008: James D Johnson; Emilyn Alejandro
Control of pancreatic beta-cell fate by insulin signaling: The sweet spot hypothesis.
Cell cycle (Georgetown, Tex.) 2008;7(10):1343-7.
2008: Jennifer L Beith; Emilyn Alejandro; James D Johnson
Insulin stimulates primary beta-cell proliferation via Raf-1 kinase.
Endocrinology 2008;149(5):2251-60.
2008: Vardit Dror; Tatyana B Kalynyak; Yaryna Bychkivska; Matthew H Z Frey; May Tee; Kristin D Jeffrey; Vy Nguyen; Dan S Luciani; James D Johnson
Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells.
The Journal of biological chemistry 2008;283(15):9909-16.
2008: Emilyn U Alejandro; James D Johnson
Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.
The Journal of biological chemistry 2008;283(4):2407-17.
2007: Dan S Luciani; Peter Ao; Xiaoke Hu; Garth L Warnock; James D Johnson
Voltage-gated Ca(2+) influx and insulin secretion in human and mouse beta-cells are impaired by the mitochondrial Na(+)/Ca(2+) exchange inhibitor CGP-37157.
European journal of pharmacology 2007;576(1-3):18-25.
2007: Garth L Warnock; Yu-Huan Theresa Liao; Xiaojie Wang; Dawei Ou; Ziliang Ao; James D Johnson; C Bruce Verchere; David Thompson
An odyssey of islet transplantation for therapy of type 1 diabetes.
World journal of surgery 2007;31(8):1569-76.
2007: Liam R Brunham; Janine K Kruit; Terry D Pape; Jenelle M Timmins; Anne Q Reuwer; Zainisha Vasanji; Brad J Marsh; Brian Rodrigues; James D Johnson; John S Parks; C Bruce Verchere; Michael R Hayden
Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.
Nature medicine 2007;13(3):340-7.
2006: James D Johnson; Ernesto Bernal-Mizrachi; Emilyn U Alejandro; Zhiqiang Han; Tatyana B Kalynyak; Hong Li; Jennifer L Beith; Julia Gross; Garth L Warnock; R Reid Townsend; M Alan Permutt; Kenneth S Polonsky
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19575-80.
2006: James D Johnson; Eric L Ford; Ernesto Bernal-Mizrachi; Kim Kusser; Dan S Luciani; Zhiqiang Han; Hung Tran; Troy D Randall; Frances E Lund; Kenneth S Polonsky
Suppressed insulin signaling and increased apoptosis in CD38-null islets.
Diabetes 2006;55(10):2737-46.
2006: Rhonda D Wideman; Irene L Y Yu; Travis D Webber; C Bruce Verchere; James D Johnson; Anthony T Cheung; Timothy J Kieffer
Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).
Proceedings of the National Academy of Sciences of the United States of America 2006;103(36):13468-73.
2005: Dan S Luciani; James D Johnson
Acute effects of insulin on beta-cells from transplantable human islets.
Molecular and cellular endocrinology 2005;241(1-2):88-98.
2005: Garth L Warnock; R Mark Meloche; David Thompson; R Jean Shapiro; Michelle Fung; Ziliang Ao; Stephen Ho; Zehua He; Long-Jun Dai; Linnea Young; Lorraine Blackburn; Sharon E Kozak; Peter T W Kim; David Al-Adra; James D Johnson; Yu-Huan Theresa Liao; Tom Elliott; C Bruce Verchere
Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus.
Archives of surgery (Chicago, Ill. : 1960) 2005;140(8):735-44.
2005: Mitsuru Ohsugi; Corentin Cras-Méneur; Yiyong Zhou; Ernesto Bernal-Mizrachi; James D Johnson; Dan S Luciani; Kenneth S Polonsky; M Alan Permutt
Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.
The Journal of biological chemistry 2005;280(6):4992-5003.
2004: Ernesto Bernal-Mizrachi; Szabolcs Fatrai; James D Johnson; Mitsuru Ohsugi; Kenichi Otani; Zhiqiang Han; Kenneth S Polonsky; M Alan Permutt
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
The Journal of clinical investigation 2004;114(7):928-36.
2004: James D Johnson; Zhiqiang Han; Kenichi Otani; Honggang Ye; Yan Zhang; Hong Wu; Yukio Horikawa; Stanley Misler; Graeme I Bell; Kenneth S Polonsky
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
The Journal of biological chemistry 2004;279(23):24794-802.
2004: James D Johnson; Shihuan Kuang; Stanley Misler; Kenneth S Polonsky
Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):878-80.
2003: James D Johnson; Noreen T Ahmed; Dan S Luciani; Zhiqiang Han; Hung Tran; Jun Fujita; Stanley Misler; Ulla Edlund; Kenneth S Polonsky
Increased islet apoptosis in Pdx1+/- mice.
The Journal of clinical investigation 2003;111(8):1147-60.
2002: James D Johnson; Stanley Misler
Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14566-71.