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Randall Johnson
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27
Mattern, Michael
16
Kingston, David
14
Hofmann, Glenn
11
Patil, Ashok
9
Freyer, Alan
8
Gunatilaka, Leslie
7
Livi, George
6
Drake, FH
6
McLaughlin, Megan
5
Hecht, Sidney
5
Zhou, Bing-Nan
5
Bergsma, DJ
4
Eggleston, Drake
3
Faucette, LF
3
Fisher, Paul
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All Publications
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2007: Marino Joseph P; Fisher Paul W; Hofmann Glenn A; Kirkpatrick Robert B; Janson Cheryl A; Johnson Randall K; Ma Chun; Mattern Michael; Meek Thomas D; Ryan M Dominic; Schulz Christina; Smith Ward W; Tew David G; Tomazek Thaddeus A; Veber Daniel F; Xiong Wenfang C; Yamamoto Yuuichi; Yamashita Keizo; Yang Guang; Thompson Scott K
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Journal of medicinal chemistry 2007;50(16):3777-85.
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2005: Kallander Lara S; Lu Qing; Chen Wenfang; Tomaszek Thaddeus; Yang Guang; Tew David; Meek Thomas D; Hofmann Glenn A; Schulz-Pritchard Christina K; Smith Ward W; Janson Cheryl A; Ryan M Dominic; Zhang Gui-Feng; Johanson Kyung O; Kirkpatrick Robert B; Ho Thau F; Fisher Paul W; Mattern Michael R; Johnson Randall K; Hansbury Michael J; Winkler James D; Ward Keith W; Veber Daniel F; Thompson Scott K
4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.
Journal of medicinal chemistry 2005;48(18):5644-7.
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2003: Prakash Chaturvedula V S; Schilling Jennifer K; Johnson Randall K; Kingston David G I
New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata.
Journal of natural products 2003;66(3):419-22.
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2002: Patil Ashok D; Freyer Alan J; Carte Brad; Taylor Paul B; Johnson Randall K; Faulkner D John
Haploscleridamine, a novel tryptamine-derived alkaloid from a sponge of the order haplosclerida: an inhibitor of cathepsin K.
Journal of natural products 2002;65(4):628-9.
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2002: Patil Ashok D; Freyer Alan J; Killmer Lew; Offen Priscilla; Taylor Paul B; Votta Bartholomew J; Johnson Randall K
A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K.
Journal of natural products 2002;65(4):624-7.
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2002: Jonak Zdenka L; Trulli Stephen; Maier Curtis; McCabe Francis L; Kirkpatrick Robert; Johanson Kyung; Ho Yen Sen; Elefante Louis; Chen Yi-Jiun; Herzyk Danuta; Lotze Michael T; Johnson Randall K
High-dose recombinant interleukin-18 induces an effective Th1 immune response to murine MOPC-315 plasmacytoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25 Suppl 1():S20-7.
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2001: Zhou B N; Johnson R K; Mattern M R; Fisher P W; Kingston D G
The first naturally occurring Tie2 kinase inhibitor.
Organic letters 2001;3(25):4047-9.
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2000: Zhou B N; Hoch J M; Johnson R K; Mattern M R; Eng W K; Ma J; Hecht S M; Newman D J; Kingston D G
Use of COMPARE analysis to discover new natural product drugs: isolation of camptothecin and 9-methoxycamptothecin from a new source.
Journal of natural products 2000;63(9):1273-6.
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2000: Schwikkard S; Zhou B N; Glass T E; Sharp J L; Mattern M R; Johnson R K; Kingston D G
Bioactive compounds from Combretum erythrophyllum.
Journal of natural products 2000;63(4):457-60.
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2000: Zhou B N; Johnson R K; Mattern M R; Wang X; Hecht S M; Beck H T; Ortiz A; Kingston D G
Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon.
Journal of natural products 2000;63(2):217-21.
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1999: Chaturvedi P; Eng W K; Zhu Y; Mattern M R; Mishra R; Hurle M R; Zhang X; Annan R S; Lu Q; Faucette L F; Scott G F; Li X; Carr S A; Johnson R K; Winkler J D; Zhou B B
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.
Oncogene 1999;18(28):4047-54.
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1999: Wu C; Johnson R K; Mattern M R; Wong J C; Kingston D G
Synthesis of furanonaphthoquinones with hydroxyamino side chains.
Journal of natural products 1999;62(7):963-8.
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1998: Zhou B N; Bahler B D; Hofmann G A; Mattern M R; Johnson R K; Kingston D G
Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity.
Journal of natural products 1998;61(11):1410-2.
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1998: Lee K K; Bahler B D; Hofmann G A; Mattern M R; Johnson R K; Kingston D G
Isolation and structure elucidation of new PKCalpha inhibitors from Pinus flexilis.
Journal of natural products 1998;61(11):1407-9.
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1998: Gunatilaka A A; Bolzani V da S; Dagne E; Hofmann G A; Johnson R K; McCabe F L; Mattern M R; Kingston D G
Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica.
Journal of natural products 1998;61(2):179-84.
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1997: Wu C; Gunatilaka A A; McCabe F L; Johnson R K; Spjut R W; Kingston D G
Bioactive and other sesquiterpenes from Chiloscyphus rivularis.
Journal of natural products 1997;60(12):1281-6.
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1997: Freyer A J; Patil A D; Killmer L; Troupe N; Mentzer M; Carte B; Faucette L; Johnson R K
Three new pseudodistomins, piperidine alkaloids from the ascidian Pseudodistoma megalarva.
Journal of natural products 1997;60(10):986-90.
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1997: Patil A D; Freyer A J; Reichwein R; Bean M F; Faucette L; Johnson R K; Haltiwanger R C; Eggleston D S
Two new nitrogenous sesquiterpenes from the sponge Axinyssa aplysinoides.
Journal of natural products 1997;60(5):507-10.
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1997: Patil A D; Freyer A J; Eggleston D S; Haltiwanger R C; Tomcowicz B; Breen A; Johnson R K
Daleformis, a new phytoalexin from the roots fo Dalea filiciformis: an inhibitor of endothelin converting enzyme.
Journal of natural products 1997;60(3):306-8.
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1997: Freyer A J; Patil A D; Killmer L; Zuber G; Myers C; Johnson R K
Rigidone, a sesquiterpene o-quinone from the gorgonian Pseudopterogorgia rigida.
Journal of natural products 1997;60(3):309-11.
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1996: Patil A D; Freyer A J; Breen A; Carte B; Johnson R K
Halistanol disulfate B, a novel sulfated sterol from the sponge Pachastrella sp.: inhibitor of endothelin converting enzyme.
Journal of natural products 1996;59(6):606-8.
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1996: Patil A D; Freyer A J; Carte B; Johnson R K; Lahouratate P
Plakortides, novel cyclic peroxides from the sponge Plakortis halichondrioides: activators of cardiac SR-CA(2+)-pumping ATPase.
Journal of natural products 1996;59(3):219-23.
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1994: Eng W K; Faucette L; McLaughlin M M; Cafferkey R; Koltin Y; Morris R A; Young P R; Johnson R K; Livi G P
The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth.
Gene 1994;151(1-2):61-71.
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1994: Stan R; McLaughlin M M; Cafferkey R; Johnson R K; Rosenberg M; Livi G P
Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue.
The Journal of biological chemistry 1994;269(51):32027-30.
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1994: Heltzel C E; Gunatilaka A A; Kingston D G; Hofmann G A; Johnson R K
Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols.
Journal of natural products 1994;57(5):620-8.
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1994: Cafferkey R; McLaughlin M M; Young P R; Johnson R K; Livi G P
Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs.
Gene 1994;141(1):133-6.
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1994: Gunatilaka A A; Kingston D G; Wijeratne E M; Bandara B M; Hofmann G A; Johnson R K
Biological activity of some coumarins from Sri Lankan Rutaceae.
Journal of natural products 1994;57(4):518-20.
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1994: Taylor P B; Culp J S; Debouck C; Johnson R K; Patil A D; Woolf D J; Brooks I; Hertzberg R P
Kinetic and mutational analysis of human immunodeficiency virus type 1 reverse transcriptase inhibition by inophyllums, a novel class of non-nucleoside inhibitors.
The Journal of biological chemistry 1994;269(9):6325-31.
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1994: Harrigan G G; Gunatilaka A A; Kingston D G; Chan G W; Johnson R K
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
Journal of natural products 1994;57(1):68-73.
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1994: Bossard M J; Bergsma D J; Brandt M; Livi G P; Eng W K; Johnson R K; Levy M A
Catalytic and ligand binding properties of the FK506 binding protein FKBP12: effects of the single amino acid substitution of Tyr82 to Leu.
The Biochemical journal 1994;297 ( Pt 2)():365-72.
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1994: McCabe F L; Johnson R K
Comparative activity of oral and parenteral topotecan in murine tumor models: efficacy of oral topotecan.
Cancer investigation 1994;12(3):308-13.
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1993: Patil A D; Freyer A J; Eggleston D S; Haltiwanger R C; Bean M F; Taylor P B; Caranfa M J; Breen A L; Bartus H R; Johnson R K
The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn.
Journal of medicinal chemistry 1993;36(26):4131-8.
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1993: Wang L K; Johnson R K; Hecht S M
Inhibition of topoisomerase I function by nitidine and fagaronine.
Chemical research in toxicology 1993;6(6):813-8.
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1993: Cafferkey R; Young P R; McLaughlin M M; Bergsma D J; Koltin Y; Sathe G M; Faucette L; Eng W K; Johnson R K; Livi G P
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.
Molecular and cellular biology 1993;13(10):6012-23.
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1993: Dagne E; Gunatilaka A A; Kingston D G; Alemu M; Hofmann G; Johnson R K
Two bioactive pterocarpans from Erythrina burana.
Journal of natural products 1993;56(10):1831-4.
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1993: Hetzel C E; Gunatilaka A A; Glass T E; Kingston D G; Hoffmann G; Johnson R K
Bioactive furanonaphthoquinones from Crescentia cujete.
Journal of natural products 1993;56(9):1500-5.
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1993: Patil A D; Baures P W; Eggleston D S; Faucette L; Hemling M E; Westley J W; Johnson R K
A screen for inhibitors of DNA recombination: identification of two new spirostanol glycosides from Chamaedorea linearis.
Journal of natural products 1993;56(9):1451-8.
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1993: Koser P L; Eng W K; Bossard M J; McLaughlin M M; Cafferkey R; Sathe G M; Faucette L; Levy M A; Johnson R K; Bergsma D J
The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding.
Gene 1993;129(2):159-65.
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1993: Mattern M R; Hofmann G A; Polsky R M; Funk L R; McCabe F L; Johnson R K
In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells.
Oncology research 1993;5(12):467-74.
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1992: Gunatilaka A A; Samaranayake G; Kingston D G; Hoffmann G; Johnson R K
Bioactive ergost-5-ene-3 beta, 7 alpha-diol derivatives from Pseudobersama mossambicensis.
Journal of natural products 1992;55(11):1648-54.
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1992: Woessner R D; Eng W K; Hofmann G A; Rieman D J; McCabe F L; Hertzberg R P; Mattern M R; Tan K B; Johnson R K
Camptothecin hyper-resistant P388 cells: drug-dependent reduction in topoisomerase I content.
Oncology research 1992;4(11-12):481-8.
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1991: Koser P L; Bergsma D J; Cafferkey R; Eng W K; McLaughlin M M; Ferrara A; Silverman C; Kasyan K; Bossard M J; Johnson R K
The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequence.
Gene 1991;108(1):73-80.
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1991: Mattern M R; Hofmann G A; McCabe F L; Johnson R K
Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864).
Cancer research 1991;51(21):5813-6.
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1991: Woessner R D; Mattern M R; Mirabelli C K; Johnson R K; Drake F H
Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(4):209-14.
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1991: Koltin Y; Faucette L; Bergsma D J; Levy M A; Cafferkey R; Koser P L; Johnson R K; Livi G P
Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.
Molecular and cellular biology 1991;11(3):1718-23.
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1991: McHale M M; Cieslinski L B; Eng W K; Johnson R K; Torphy T J; Livi G P
Expression of human recombinant cAMP phosphodiesterase isozyme IV reverses growth arrest phenotypes in phosphodiesterase-deficient yeast.
Molecular pharmacology 1991;39(2):109-13.
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1991: Hoke G D; McCabe F L; Faucette L F; Bartus J O; Sung C M; Jensen B D; Heys J R; Rush G F; Alberts D W; Johnson R K
In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane.
Molecular pharmacology 1991;39(1):90-7.
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1991: Kingsbury W D; Boehm J C; Jakas D R; Holden K G; Hecht S M; Gallagher G; Caranfa M J; McCabe F L; Faucette L F; Johnson R K
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
Journal of medicinal chemistry 1991;34(1):98-107.
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1991: Mattern M R; Nambi P; Bartus J O; Mirabelli C K; Crooke S T; Johnson R K
Regulation of topoisomerase I and II activities by cyclic nucleotide- and phospholipid-dependent protein kinases. Effects of interactions between the two transduction pathways.
Receptor 1991;1(3):181-90.
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1990: Hertzberg R P; Busby R W; Caranfa M J; Holden K G; Johnson R K; Hecht S M; Kingsbury W D
Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site.
The Journal of biological chemistry 1990;265(31):19287-95.
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1990: Eng W K; McCabe F L; Tan K B; Mattern M R; Hofmann G A; Woessner R D; Hertzberg R P; Johnson R K
Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content.
Molecular pharmacology 1990;38(4):471-80.
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1990: Berners-Price S J; Girard G R; Hill D T; Sutton B M; Jarrett P S; Faucette L F; Johnson R K; Mirabelli C K; Sadler P J
Cytotoxicity and antitumor activity of some tetrahedral bis(diphosphino)gold(I) chelates.
Journal of medicinal chemistry 1990;33(5):1386-92.
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1990: Woessner R D; Chung T D; Hofmann G A; Mattern M R; Mirabelli C K; Drake F H; Johnson R K
Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II.
Cancer research 1990;50(10):2901-8.
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1989: Tan K B; Mattern M R; Eng W K; McCabe F L; Johnson R K
Nonproductive rearrangement of DNA topoisomerase I and II genes: correlation with resistance to topoisomerase inhibitors.
Journal of the National Cancer Institute 1989;81(22):1732-5.
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1989: Mattern M R; Tan K B; Zimmerman J P; Mong S M; Bartus J O; Hofmann G A; Drake F H; Johnson R K; Crooke S T; Mirabelli C K
Evidence for the participation of topoisomerases I and II in cadmium-induced metallothionein expression in Chinese hamster ovary cells.
Anti-cancer drug design 1989;4(2):107-24.
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1989: Drake F H; Hofmann G A; Mong S M; Bartus J O; Hertzberg R P; Johnson R K; Mattern M R; Mirabelli C K
In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.
Cancer research 1989;49(10):2578-83.
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1989: Mirabelli C K; Badger A M; Sung C P; Hillegass L; Sung C M; Johnson R K; Picker D; Schwartz D; Dorman J; Martellucci S
Pharmacological activities of spirogermanium and other structurally related azaspiranes: effects on tumor cell and macrophage functions.
Anti-cancer drug design 1989;3(4):231-42.
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1989: Hertzberg R P; Caranfa M J; Holden K G; Jakas D R; Gallagher G; Mattern M R; Mong S M; Bartus J O; Johnson R K; Kingsbury W D
Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity.
Journal of medicinal chemistry 1989;32(3):715-20.
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1988: Eng W K; Faucette L; Johnson R K; Sternglanz R
Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.
Molecular pharmacology 1988;34(6):755-60.
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1988: Gupta R S; Gupta R; Eng B; Lock R B; Ross W E; Hertzberg R P; Caranfa M J; Johnson R K
Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.
Cancer research 1988;48(22):6404-10.
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1988: Mirabelli C K; Sung C M; McCabe F L; Faucette L F; Crooke S T; Johnson R K
A murine model to evaluate the ability of in vitro clonogenic assays to predict the response to tumors in vivo.
Cancer research 1988;48(19):5447-54.
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1988: Berners-Price S J; Johnson R K; Giovenella A J; Faucette L F; Mirabelli C K; Sadler P J
Antimicrobial and anticancer activity of tetrahedral, chelated, diphosphine silver(I) complexes: comparison with copper and gold.
Journal of inorganic biochemistry 1988;33(4):285-95.
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1988: Stadel J M; Johnson R K; Mirabelli C K; Powers D A; Sung C M; Faucette L F; McCabe F L; Crooke S T
Tumorigenicity of the cyc- variant of the S49 murine lymphoma deficient in the Gs-alpha subunit of adenylate cyclase.
Cancer research 1988;48(3):641-4.
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1987: Mirabelli C K; Hill D T; Faucette L F; McCabe F L; Girard G R; Bryan D B; Sutton B M; Bartus J O; Crooke S T; Johnson R K
Antitumor activity of bis(diphenylphosphino)alkanes, their gold(I) coordination complexes, and related compounds.
Journal of medicinal chemistry 1987;30(12):2181-90.
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1987: Drake F H; Zimmerman J P; McCabe F L; Bartus H F; Per S R; Sullivan D M; Ross W E; Mattern M R; Johnson R K; Crooke S T
Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.
The Journal of biological chemistry 1987;262(34):16739-47.
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1987: Per S R; Mattern M R; Mirabelli C K; Drake F H; Johnson R K; Crooke S T
Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function.
Molecular pharmacology 1987;32(1):17-25.
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1987: Mattern M R; Mong S M; Bartus H F; Mirabelli C K; Crooke S T; Johnson R K
Relationship between the intracellular effects of camptothecin and the inhibition of DNA topoisomerase I in cultured L1210 cells.
Cancer research 1987;47(7):1793-8.
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1986: Berners-Price S J; Mirabelli C K; Johnson R K; Mattern M R; McCabe F L; Faucette L F; Sung C M; Mong S M; Sadler P J; Crooke S T
In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride.
Cancer research 1986;46(11):5486-93.
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1986: Mirabelli C K; Jensen B D; Mattern M R; Sung C M; Mong S M; Hill D T; Dean S W; Schein P S; Johnson R K; Crooke S T
Cellular pharmacology of mu-[1,2-bis(diphenylphosphino)ethane]bis[(1-thio-beta-D-gluco pyranosato-S)gold(I)]: a novel antitumor agent.
Anti-cancer drug design 1986;1(3):223-34.
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1986: Snyder R M; Mirabelli C K; Johnson R K; Sung C M; Faucette L F; McCabe F L; Zimmerman J P; Whitman M; Hempel J C; Crooke S T
Modulation of the antitumor and biochemical properties of bis(diphenylphosphine)ethane with metals.
Cancer research 1986;46(10):5054-60.
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1986: Mirabelli C K; Johnson R K; Hill D T; Faucette L F; Girard G R; Kuo G Y; Sung C M; Crooke S T
Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes.
Journal of medicinal chemistry 1986;29(2):218-23.
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1985: Mirabelli C K; Johnson R K; Sung C M; Faucette L; Muirhead K; Crooke S T
Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models.
Cancer research 1985;45(1):32-9.
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