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Randall Johnson

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Yan Huang; Randall S Johnson; Ion S Jovin; Li Lei; Dinggang Liu; Raymond Russell; Annarita Di Lorenzo; Frank J Giordano
Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function.
Cheryl Y M Okumura; Joshua Olson; Robert A Shalwitz; Wdee Thienphrapa; Dan N Tran; Maren von Köckritz-Blickwede; Courtney Corle; Samira Dahesh; Andrew Hollands; Seung Nam Jeung; Randall S Johnson; Anna Kotsakis; Victor Nizet
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.
Jung-whan Kim; Yun Sok Lee; Gustavo Leone; Michael C Ostrowski; Christian Stockmann; Norihiko Takeda; Alexander Weidemann; Cristina Branco-Price; Filip Brandberg; Colin Evans; Randall S Johnson
Loss of fibroblast HIF-1α accelerates tumorigenesis.

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All Publications

2012: Yan Huang; Randall S Johnson; Ion S Jovin; Li Lei; Dinggang Liu; Raymond Russell; Annarita Di Lorenzo; Frank J Giordano
Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(43):17478-83.
2012: Cheryl Y M Okumura; Joshua Olson; Robert A Shalwitz; Wdee Thienphrapa; Dan N Tran; Maren von Köckritz-Blickwede; Courtney Corle; Samira Dahesh; Andrew Hollands; Seung Nam Jeung; Randall S Johnson; Anna Kotsakis; Victor Nizet
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.
Journal of molecular medicine (Berlin, Germany) 2012;90(9):1079-89.
2012: Jung-whan Kim; Yun Sok Lee; Gustavo Leone; Michael C Ostrowski; Christian Stockmann; Norihiko Takeda; Alexander Weidemann; Cristina Branco-Price; Filip Brandberg; Colin Evans; Randall S Johnson
Loss of fibroblast HIF-1α accelerates tumorigenesis.
Cancer research 2012;72(13):3187-95.
2012: Colin E Evans; Cristina Branco-Price; Randall S Johnson
HIF-mediated endothelial response during cancer progression.
International journal of hematology 2012;95(5):471-7.
2012: Cristina Branco-Price; Lesley Ellies; Colin Evans; Dörthe M Katschinski; Debbie Liao; Moritz Schnelle; Na Zhang; Randall S Johnson
Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success.
Cancer cell 2012;21(1):52-65.
2011: Toshihide Kurihara; Peter D Westenskow; Edith Aguilar; Randall S Johnson; Tim Krohne; Martin Friedlander
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye.
The Journal of cell biology 2011;195(4):689-701.
2010: Andrew Doedens; Christian Stockmann; Mark P Rubinstein; Debbie Liao; Na Zhang; David G DeNardo; Lisa M Coussens; Michael Karin; Ananda W Goldrath; Randall S Johnson
Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression.
Cancer research 2010;70(19):7465-75.
2010: Alexander Weidemann; Tim Krohne; Edith Aguilar; Toshihide Kurihara; Norihiko Takeda; Michael I Dorrell; M Celeste Simon; Volker H Haase; Martin Friedlander; Randall S Johnson
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina.
Glia 2010;58(10):1177-85.
2010: Na Zhang; Zhenxing Fu; Sarah Linke; Johana Chicher; Jeffrey J Gorman; DeeAnn Visk; Gabriel G Haddad; Lorenz Poellinger; Daniel J Peet; Frank Powell; Randall S Johnson
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.
Cell metabolism 2010;11(5):364-78.
2010: Christian Stockmann; Yann Kerdiles; Marc Nomaksteinsky; Alexander Weidemann; Norihiko Takeda; Andrew Doedens; Antonio X Torres-Collado; Luisa Iruela-Arispe; Victor Nizet; Randall S Johnson
Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4329-34.
2010: Norihiko Takeda; Ellen L O'Dea; Andrew Doedens; Jung-whan Kim; Alexander Weidemann; Christian Stockmann; Masataka Asagiri; M Celeste Simon; Alexander Hoffmann; Randall S Johnson
Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis.
Genes & development 2010;24(5):491-501.
2010: Andrew Scott; Michael B Powner; Pranita Gandhi; Claire Clarkin; David H Gutmann; Randall S Johnson; Napoleone Ferrara; Marcus Fruttiger
Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature.
PloS one 2010;5(7):e11863.
2010: Helene Rundqvist; Randall S Johnson
Hypoxia and metastasis in breast cancer.
Current topics in microbiology and immunology 2010;345():121-39.
2009: Alexander Weidemann; Yann M Kerdiles; Karl X Knaup; Christopher A Rafie; Adam T Boutin; Christian Stockmann; Norihiko Takeda; Miriam Scadeng; Andy Y Shih; Volker H Haase; M Celeste Simon; David Kleinfeld; Randall S Johnson
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.
The Journal of clinical investigation 2009;119(11):3373-83.
2009: Victor Nizet; Randall S Johnson
Interdependence of hypoxic and innate immune responses.
Nature reviews. Immunology 2009;9(9):609-17.
2009: Jung-whan Kim; Randall S Johnson
You don't need a PHD to grow a tumor.
Developmental cell 2009;16(6):781-2.
2009: Alexander Weidemann; Randall S Johnson
Nonrenal regulation of EPO synthesis.
Kidney international 2009;75(7):682-8.
2008: Sarah Bray; Randall S Johnson
Putting the tissue and environmental 'context' into differentiation and gene regulation.
Current opinion in genetics & development 2008;18(5):395-6.
2008: Erinn B Rankin; Jennifer Rha; Travis L Unger; Chia H Wu; Heather P Shutt; Randall S Johnson; M Celeste Simon; Brian Keith; Volker H Haase
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice.
Oncogene 2008;27(40):5354-8.
2008: Carole Peyssonnaux; Adam T. Boutin; Annelies S Zinkernagel; Vivekanand Datta; Victor Nizet; Randall S Johnson
Critical role of HIF-1alpha in keratinocyte defense against bacterial infection.
The Journal of investigative dermatology 2008;128(8):1964-8.
2008: Jordi Rius; Monica Guma; Christian Schachtrup; Katerina Akassoglou; Annelies S Zinkernagel; Victor Nizet; Randall S Johnson; Gabriel G Haddad; Michael Karin
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
Nature 2008;453(7196):807-11.
2008: Li Lei; Steve Mason; Dinggang Liu; Yan Huang; Carolyn Marks; Reed Hickey; Ion S Jovin; Marc Pypaert; Randall S Johnson; Frank J Giordano
Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein.
Molecular and cellular biology 2008;28(11):3790-803.
2008: Adam T. Boutin; Alexander Weidemann; Zhenxing Fu; Lernik Mesropian; Katarina Gradin; Colin Jamora; Michael Wiesener; Kai-Uwe Eckardt; Cameron J Koch; Lesley G Ellies; Gabriel Haddad; Volker H Haase; M Celeste Simon; Lorenz Poellinger; Frank L Powell; Randall S Johnson
Epidermal sensing of oxygen is essential for systemic hypoxic response.
Cell 2008;133(2):223-34.
2008: A Weidemann; Randall S Johnson
Biology of HIF-1alpha.
Cell death and differentiation 2008;15(4):621-7.
2008: Annelies S Zinkernagel; Carole Peyssonnaux; Randall S Johnson; Victor Nizet
Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes.
The Journal of infectious diseases 2008;197(2):214-7.
2008: Carole Peyssonnaux; Victor Nizet; Randall S Johnson
Role of the hypoxia inducible factors HIF in iron metabolism.
Cell cycle (Georgetown, Tex.) 2008;7(1):28-32.
2007: Debra Higgins; Kuniko Kimura; Wanja M Bernhardt; Nikita Shrimanker; Yasuhiro Akai; Bernd Hohenstein; Yoshihiko Saito; Randall S Johnson; Matthias Kretzler; Clemens D Cohen; Kai-Uwe Eckardt; Masayuki Iwano; Volker H Haase
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.
The Journal of clinical investigation 2007;117(12):3810-20.
2007: Annelies S Zinkernagel; Randall S Johnson; Victor Nizet
Hypoxia inducible factor (HIF) function in innate immunity and infection.
Journal of molecular medicine (Berlin, Germany) 2007;85(12):1339-46.
2007: Steven D Mason; Helene Rundqvist; Ioanna Papandreou; Roger Duh; Wayne McNulty; Richard A Howlett; I Mark Olfert; Carl Johan Sundberg; Nicholas C Denko; Lorenz Poellinger; Randall S Johnson
HIF-1alpha in endurance training: suppression of oxidative metabolism.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(5):R2059-69.
2007: Henry K Bayele; Carole Peyssonnaux; Alexandra Giatromanolaki; Wagner Welber Arrais-Silva; Hiba S Mohamed; Helen Collins; Selma Giorgio; Michael Koukourakis; Randall S Johnson; Jenefer M Blackwell; Victor Nizet; Kaila Surjit Srai
HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite.
Blood 2007;110(8):3039-48.
2007: Barbara Blouw; Volker H Haase; H Song; Gabriele Bergers; Randall S Johnson
Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.
Oncogene 2007;26(31):4531-40.
2007: Carole Peyssonnaux; Annelies S Zinkernagel; Reto A Schuepbach; Erinn B Rankin; Sophie Vaulont; Volker H Haase; Victor Nizet; Randall S Johnson
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).
The Journal of clinical investigation 2007;117(7):1926-32.
2007: Carole Peyssonnaux; Pilar Cejudo-Martin; Andrew Doedens; Annelies S Zinkernagel; Randall S Johnson; Victor Nizet
Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7516-9.
2007: Oxana Baranova; Luis F Miranda; Paola Pichiule; Ioannis Dragatsis; Randall S Johnson; Juan C Chavez
Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(23):6320-32.
2007: Randall S Johnson; L Eric Huang
Can irradiated tumors take NO for an answer?
Molecular cell 2007;26(2):157-8.
2007: Adam T. Boutin; Randall S Johnson
Waiting to inhale: HIF-1 modulates aerobic respiration.
Cell 2007;129(1):29-30.
2007: Erinn B Rankin; Mangatt P Biju; Qingdu Liu; Travis L Unger; Jennifer Rha; Randall S Johnson; M Celeste Simon; Brian Keith; Volker H Haase
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
The Journal of clinical investigation 2007;117(4):1068-77.
2007: Michaela Gruber; Cheng-Jun Hu; Randall S Johnson; Eric J Brown; Brian Keith; M Celeste Simon
Acute postnatal ablation of Hif-2alpha results in anemia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2301-6.
2007: Sang-Ki Park; Volker H Haase; Randall S Johnson
von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase.
International journal of oncology 2007;30(2):341-8.
2007: Debbie Liao; Courtney Corle; Tiffany N. Seagroves; Randall S Johnson
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.
Cancer research 2007;67(2):563-72.
2007: Steven Mason; Randall S Johnson
The role of HIF-1 in hypoxic response in the skeletal muscle.
Advances in experimental medicine and biology 2007;618():229-44.
2007: Andrew Doedens; Randall S Johnson
Transgenic models to understand hypoxia-inducible factor function.
Methods in enzymology 2007;435():87-105.
2006: Carole Peyssonnaux; Annelies S Zinkernagel; Vivekanand Datta; Xavier Lauth; Randall S Johnson; Victor Nizet
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens.
Blood 2006;107(9):3727-32.
2005: Aaron K Neumann; Jaeseok Yang; Mangatt P Biju; Suresh K Joseph; Randall S Johnson; Volker H Haase; Bruce D Freedman; Laurence A Turka
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17071-6.
2005: Pilar Cejudo-Martin; Randall S Johnson
A new notch in the HIF belt: how hypoxia impacts differentiation.
Developmental cell 2005;9(5):575-6.
2005: Carole Peyssonnaux; Vivekanand Datta; Thorsten Cramer; Andrew Doedens; Emmanuel A Theodorakis; Richard L Gallo; Nancy Hurtado-Ziola; Victor Nizet; Randall S Johnson
HIF-1alpha expression regulates the bactericidal capacity of phagocytes.
The Journal of clinical investigation 2005;115(7):1806-15.
2005: Robert Helton; Jiankun Cui; John R Scheel; Julie A Ellison; Chris Ames; Claire Gibson; Barbara Blouw; Ling Ouyang; Ioannis Dragatsis; Scott Zeitlin; Randall S Johnson; Stuart A Lipton; Carrolee Barlow
Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(16):4099-107.
2005: Erinn B Rankin; Debra Higgins; Jacqueline A Walisser; Randall S Johnson; Christopher A Bradfield; Volker H Haase
Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.
Molecular and cellular biology 2005;25(8):3163-72.
2005: Jared W Allen; Randall S Johnson; Sangeeta N Bhatia
Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha.
Toxicology letters 2005;155(1):151-9.
2005: Sarah R Walmsley; Cristin G Print; Neda Farahi; Carole Peyssonnaux; Randall S Johnson; Thorsten Cramer; Anastasia Sobolewski; Alison M Condliffe; Andrew S Cowburn; Nicola Johnson; Edwin R Chilvers
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.
The Journal of experimental medicine 2005;201(1):105-15.
2004: Debra Higgins; Mangatt P Biju; Yasuhiro Akai; Anton Wutz; Randall S Johnson; Volker H Haase
Hypoxic induction of Ctgf is directly mediated by Hif-1.
American journal of physiology. Renal physiology 2004;287(6):F1223-32.
2004: Nan Tang; Lianchun Wang; Jeffrey Esko; Frank J Giordano; Yan Huang; Hans-Peter Gerber; Napoleone Ferrara; Randall S Johnson
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.
Cancer cell 2004;6(5):485-95.
2004: Mangatt P Biju; Aaron K Neumann; Steven J Bensinger; Randall S Johnson; Laurence A Turka; Volker H Haase
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes.
Molecular and cellular biology 2004;24(20):9038-47.
2004: Steven D Mason; Richard A Howlett; Matthew J Kim; I Mark Olfert; Michael C Hogan; Wayne McNulty; Reed P Hickey; Peter D Wagner; C Ronald Kahn; Frank J Giordano; Randall S Johnson
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
PLoS biology 2004;2(10):e288.
2004: Yan Huang; Reed P Hickey; Jennifer L Yeh; Dinggang Liu; Agnes Dadak; Lawrence H Young; Randall S Johnson; Frank J Giordano
Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(10):1138-40.
2004: Thorsten Cramer; Ernestina Schipani; Randall S Johnson; Bernd Swoboda; David Pfander
Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1 alpha dependent.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(6):433-9.
2004: Keith R Laderoute; Joy M Calaoagan; Merrill Knapp; Randall S Johnson
Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun.
Molecular and cellular biology 2004;24(10):4128-37.
2004: Carole Peyssonaux; Randall S Johnson
An unexpected role for hypoxic response: oxygenation and inflammation.
Cell cycle (Georgetown, Tex.) 2004;3(2):168-71.
2003: Nobuhito Goda; Sara J Dozier; Randall S Johnson
HIF-1 in cell cycle regulation, apoptosis, and tumor progression.
Antioxidants & redox signaling 2003;5(4):467-73.
2003: Barbara Blouw; Hanqiu Song; Tarik Tihan; Jenel Bosze; Napoleone Ferrara; Hans-Peter Gerber; Randall S Johnson; Gabriele Bergers
The hypoxic response of tumors is dependent on their microenvironment.
Cancer cell 2003;4(2):133-46.
2003: Sang-Ki Park; Agnes Dadak; Volker H Haase; Lucrezia Fontana; Amato J Giaccia; Randall S Johnson
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.
Molecular and cellular biology 2003;23(14):4959-71.
2003: Guochun Li; Cindy Gustafson-Brown; Steven K Hanks; Katie Nason; Jeffrey M Arbeit; Kit Pogliano; Ronald M Wisdom; Randall S Johnson
c-Jun is essential for organization of the epidermal leading edge.
Developmental cell 2003;4(6):865-77.
2003: Thorsten Cramer; Randall S Johnson
A novel role for the hypoxia inducible transcription factor HIF-1alpha: critical regulation of inflammatory cell function.
Cell cycle (Georgetown, Tex.) 2003;2(3):192-3.
2003: Valia T Mihaylova; Ranjit Bindra; Jianling Yuan; Denise Campisi; Latha Narayanan; Ryan B. Jensen; Frank Giordano; Randall S Johnson; Sara Rockwell; Peter M Glazer
Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells.
Molecular and cellular biology 2003;23(9):3265-73.
2003: Tiffany N. Seagroves; Darryl L Hadsell; Jim McManaman; Carol Palmer; Debbie Liao; Wayne McNulty; Bryan E. Welm; Kay-Uwe Wagner; Margaret Neville; Randall S Johnson
HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.
Development (Cambridge, England) 2003;130(8):1713-24.
2003: Thorsten Cramer; Yuji Yamanishi; Björn E Clausen; Irmgard Förster; Rafal Pawlinski; Nigel Mackman; Volker H Haase; Rudolf Jaenisch; Maripat Corr; Victor Nizet; Gary S Firestein; Hans-Peter Gerber; Napoleone Ferrara; Randall S Johnson
HIF-1alpha is essential for myeloid cell-mediated inflammation.
Cell 2003;112(5):645-57.
2003: Nobuhito Goda; Heather E Ryan; Bahram Khadivi; Wayne McNulty; Robert C Rickert; Randall S Johnson
Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia.
Molecular and cellular biology 2003;23(1):359-69.
2002: M Palmada; Sujata Kanwal; Nancy J Rutkoski; Cindy Gustafson-Brown; Randall S Johnson; R Wisdom; Bruce D Carter; C Gufstafson-Brown
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
The Journal of cell biology 2002;158(3):453-61.
2002: Tiffany N. Seagroves; Randall S Johnson
Two HIFs may be better than one.
Cancer cell 2002;1(3):211-3.
2002: Keith R Laderoute; Joy M Calaoagan; Cindy Gustafson-Brown; A Merrill Knapp; Guo-Chun Li; Holly L Mendonca; Heather E Ryan; Zhaohui Wang; Randall S Johnson
The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent.
Molecular and cellular biology 2002;22(8):2515-23.
2001: Keith R Laderoute; Joy M Calaoagan; A Merrill Knapp; Holly L Mendonca; Randall S Johnson
c-jun cooperates with SV40 T-antigen to sustain MMP-2 expression in immortalized cells.
Biochemical and biophysical research communications 2001;284(5):1134-9.
2001: Tiffany N. Seagroves; Heather E Ryan; H Lu; B G Wouters; M Knapp; Pierre Thibault; Keith R Laderoute; Randall S Johnson
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.
Molecular and cellular biology 2001;21(10):3436-44.
2001: Frank J Giordano; Randall S Johnson
Angiogenesis: the role of the microenvironment in flipping the switch.
Current opinion in genetics & development 2001;11(1):35-40.
2000: J Grunstein; J J Masbad; Reed Hickey; Frank Giordano; Randall S Johnson
Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature.
Molecular and cellular biology 2000;20(19):7282-91.
2000: Heather E Ryan; M Poloni; Wayne McNulty; DA Elson; M Gassmann; Jeffrey M Arbeit; Randall S Johnson
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.
Cancer research 2000;60(15):4010-5.
2000: Constantin Makris; Virginia L Godfrey; G Krähn-Senftleben; T Takahashi; J L Roberts; T Schwarz; L Feng; Randall S Johnson; Michael Karin
Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti.
Molecular cell 2000;5(6):969-79.
1999: M J Dealy; K V Nguyen; J Lo; Matthias Gstaiger; Wilhelm Krek; DA Elson; Jeffrey M Arbeit; Edward T Kipreos; Randall S Johnson
Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E.
Nature genetics 1999;23(2):245-8.
1998: Heather E Ryan; J Lo; Randall S Johnson
HIF-1 alpha is required for solid tumor formation and embryonic vascularization.
The EMBO journal 1998;17(11):3005-15.