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Ricky Johnstone
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Research Profile (preview)
Chemicals & Drugs
Living Beings
Disorders
Anatomy
Physiology
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Network (preview)
17
Smyth, Mark
15
Trapani, Joseph
11
Ruefli, Astrid
10
Clarke, Christopher
9
Tainton, Kellie
8
Lindemann, Ralph
4
Peart, Melissa
4
Prince, Miles
3
Sedelies, Karin
3
Kofler, Reinhard
3
Cluse, Leonie
3
Bernhard, David
3
Atadja, Peter
3
Darcy, Phillip
3
Browne, Kylie
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Publications
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All Publications
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2009: Frew Ailsa J; Johnstone Ricky W; Bolden Jessica E
Enhancing the apoptotic and therapeutic effects of HDAC inhibitors.
Cancer letters 2009;280(2):125-33.
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2009: Ellis Leigh; Bots Michael; Lindemann Ralph K; Bolden Jessica E; Newbold Andrea; Cluse Leonie A; Scott Clare L; Strasser Andreas; Atadja Peter; Lowe Scott W; Johnstone Ricky W
The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy.
Blood 2009;114(2):380-93.
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2009: Prince H Miles; Bishton Mark J; Johnstone Ricky W
Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors.
Future oncology (London, England) 2009;5(5):601-12.
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2009: Ellis Leigh; Atadja Peter W; Johnstone Ricky W
Epigenetics in cancer: targeting chromatin modifications.
Molecular cancer therapeutics 2009;8(6):1409-20.
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2009: Bots Michael; Johnstone Ricky W
Rational combinations using HDAC inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):3970-7.
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2009: Bolitho Paul; Street Shayna E A; Westwood Jennifer A; Edelmann Winfried; Macgregor Duncan; Waring Paul; Murray William K; Godfrey Dale I; Trapani Joseph A; Johnstone Ricky W; Smyth Mark J
Perforin-mediated suppression of B-cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2723-8.
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2009: Whitecross Kate F; Alsop Amber E; Cluse Leonie A; Wiegmans Adrian; Banks Kellie-Marie; Coomans Claudia; Peart Melissa J; Newbold Andrea; Lindemann Ralph K; Johnstone Ricky W
Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors.
Blood 2009;113(9):1982-91.
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2009: Algar Elizabeth M; Muscat Andrea; Dagar Vinod; Rickert Christian; Chow C W; Biegel Jaclyn A; Ekert Paul G; Saffery Richard; Craig Jeff; Johnstone Ricky W; Ashley David M
Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors.
PloS one 2009;4(2):e4482.
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2008: Gough Daniel J; Levy David E; Johnstone Ricky W; Clarke Christopher J
IFNgamma signaling-does it mean JAK-STAT?
Cytokine & growth factor reviews 2008;19(5-6):383-94.
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2008: Stagg John; Sharkey Janelle; Pommey Sandra; Young Richard; Takeda Kazuyoshi; Yagita Hideo; Johnstone Ricky W; Smyth Mark J
Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16254-9.
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2008: Johnstone Ricky W; Frew Ailsa J; Smyth Mark J
The TRAIL apoptotic pathway in cancer onset, progression and therapy.
Nature reviews. Cancer 2008;8(10):782-98.
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2008: Frew Ailsa J; Lindemann Ralph K; Martin Ben P; Clarke Christopher J P; Sharkey Janelle; Anthony Desiree A; Banks Kellie-Marie; Haynes Nicole M; Gangatirkar Pradnya; Stanley Kym; Bolden Jessica E; Takeda Kazuyoshi; Yagita Hideo; Secrist J Paul; Smyth Mark J; Johnstone Ricky W
Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11317-22.
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2008: Ellis Leigh; Pan Yan; Smyth Gordon K; George Daniel J; McCormack Chris; Williams-Truax Roxanne; Mita Monica; Beck Joachim; Burris Howard; Ryan Gail; Atadja Peter; Butterfoss Dale; Dugan Margaret; Culver Kenneth; Johnstone Ricky W; Prince H Miles
Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(14):4500-10.
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2008: Newbold Andrea; Lindemann Ralph K; Cluse Leonie A; Whitecross Kate F; Dear Anthony E; Johnstone Ricky W
Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin.
Molecular cancer therapeutics 2008;7(5):1066-79.
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2008: Rasheed Walid; Bishton Mark; Johnstone Ricky W; Prince H Miles
Histone deacetylase inhibitors in lymphoma and solid malignancies.
Expert review of anticancer therapy 2008;8(3):413-32.
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2008: Ludlow Louise E; Hii Linda L; Thorpe Janine; Newbold Andrea; Tainton Kellie M; Trapani Joseph A; Clarke Christopher J P; Johnstone Ricky W
Cloning and characterisation of Ifi206: a new murine HIN-200 family member.
Journal of cellular biochemistry 2008;103(4):1270-82.
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2008: Ludlow Louise E; Purton Louise E; Klarmann Kim; Gough Daniel J; Hii Linda L; Trapani Joseph A; Keller Jonathan R; Clarke Christopher J P; Johnstone Ricky W
The role of p202 in regulating hematopoietic cell proliferation and differentiation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2008;28(1):5-11.
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2007: Nguyen Mai; Marcellus Richard C; Roulston Anne; Watson Mark; Serfass Lucile; Murthy Madiraju S R; Goulet Daniel; Viallet Jean; Bélec Laurent; Billot Xavier; Acoca Stephane; Purisima Enrico; Wiegmans Adrian; Cluse Leonie; Johnstone Ricky W; Beauparlant Pierre; Shore Gordon C
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19512-7.
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2007: Stagg John; Johnstone Ricky W; Smyth Mark J
From cancer immunosurveillance to cancer immunotherapy.
Immunological reviews 2007;220():82-101.
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2007: Lindemann R K; Newbold A; Whitecross K F; Cluse L A; Frew A J; Ellis L; Williams S; Wiegmans A P; Dear A E; Scott C L; Pellegrini M; Wei A; Richon V M; Marks Paul A; Lowe S W; Smyth M J; Johnstone R W
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8071-6.
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2007: Rasheed Walid K; Johnstone Ricky W; Prince H Miles
Histone deacetylase inhibitors in cancer therapy.
Expert opinion on investigational drugs 2007;16(5):659-78.
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2007: Kaufmann Thomas; Tai Lin; Ekert Paul G; Huang David C S; Norris Fiona; Lindemann Ralph K; Johnstone Ricky W; Dixit Vishva M; Strasser Andreas
The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest.
Cell 2007;129(2):423-33.
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2007: Gough Daniel J; Sabapathy Kanaga; Ko Enoch Yi-No; Arthur Helen A; Schreiber Robert D; Trapani Joseph A; Clarke Christopher J P; Johnstone Ricky W
A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes.
The Journal of biological chemistry 2007;282(2):938-46.
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2006: Bolden Jessica E; Peart Melissa J; Johnstone Ricky W
Anticancer activities of histone deacetylase inhibitors.
Nature reviews. Drug discovery 2006;5(9):769-84.
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2005: Baker Emma K; Johnstone Ricky W; Zalcberg John R; El-Osta Assam
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
Oncogene 2005;24(54):8061-75.
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2005: Ludlow Louise E A; Johnstone Ricky W; Clarke Christopher J P
The HIN-200 family: more than interferon-inducible genes?
Experimental cell research 2005;308(1):1-17.
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2005: Peart Melissa J; Smyth Gordon K; van Laar Ryan K; Bowtell David D; Richon Victoria M; Marks Paul A; Holloway Andrew J; Johnstone Ricky W
Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3697-702.
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2005: Waterhouse Nigel J; Sedelies Karin A; Browne Kylie A; Wowk Michelle E; Newbold Andrea; Sutton Vivien R; Clarke Chris J P; Oliaro Jane; Lindemann Ralph K; Bird Phillip I; Johnstone Ricky W; Trapani Joseph A
A central role for Bid in granzyme B-induced apoptosis.
The Journal of biological chemistry 2005;280(6):4476-82.
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2005: Cresswell Kim S; Clarke Christopher J P; Jackson Jacob T; Darcy Phillip K; Trapani Joseph A; Johnstone Ricky W
Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2.
Biochemical and biophysical research communications 2005;326(2):417-24.
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2004: Tainton K M; Smyth M J; Jackson J T; Tanner J E; Cerruti L; Jane S M; Darcy P K; Johnstone R W
Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.
Cell death and differentiation 2004;11(9):1028-37.
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2004: Johnstone Ricky W
Suberanilohydroxamic Acid. Aton Pharma.
IDrugs : the investigational drugs journal 2004;7(7):674-82.
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2004: Lindemann Ralph K; Gabrielli Brian; Johnstone Ricky W
Histone-deacetylase inhibitors for the treatment of cancer.
Cell cycle (Georgetown, Tex.) 2004;3(6):779-88.
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2003: Aglipay Jason A; Lee Sam W; Okada Shinya; Fujiuchi Nobuko; Ohtsuka Takao; Kwak Jennifer C; Wang Yi; Johnstone Ricky W; Deng Chuxia; Qin Jun; Ouchi Toru
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
Oncogene 2003;22(55):8931-8.
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2003: Darnell Grant A; Antalis Toni M; Johnstone Ricky W; Stringer Brett W; Ogbourne Steven M; Harrich David; Suhrbier Andreas
Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif.
Molecular and cellular biology 2003;23(18):6520-32.
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2003: Peart Melissa J; Tainton Kellie M; Ruefli Astrid A; Dear Anthony E; Sedelies Karin A; O'Reilly Lorraine A; Waterhouse Nigel J; Trapani Joseph A; Johnstone Ricky W
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.
Cancer research 2003;63(15):4460-71.
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2003: Xin Hong; Curry Jonathan; Johnstone Ricky W; Nickoloff Brian J; Choubey Divaker
Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence.
Oncogene 2003;22(31):4831-40.
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2003: Johnstone Ricky W; Licht Jonathan D
Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?
Cancer cell 2003;4(1):13-8.
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2003: Clarke C J P; Apostolidis V; Hii L L P; Gough D J; Trapani J A; Johnstone R W
Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16.
Journal of cellular biochemistry 2003;89(1):80-93.
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2003: Wei Wu; Clarke Christopher J P; Somers Gino R; Cresswell Kim S; Loveland Kate A; Trapani Joseph A; Johnstone Ricky W
Expression of IFI 16 in epithelial cells and lymphoid tissues.
Histochemistry and cell biology 2003;119(1):45-54.
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2002: Crazzolara Roman; Jöhrer Karin; Johnstone Ricky W; Greil Richard; Kofler Reinhard; Meister Bernhard; Bernhard David
Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemia.
British journal of haematology 2002;119(4):965-9.
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2002: Ruefli A A; Tainton K M; Darcy P K; Smyth M J; Johnstone R W
P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation.
Cell death and differentiation 2002;9(11):1266-72.
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2002: Johnstone Ricky W
Deamidation of Bcl-X(L): a new twist in a genotoxic murder mystery.
Molecular cell 2002;10(4):695-7.
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2002: Ruefli Astrid A; Bernhard David; Tainton Kellie M; Kofler Reinhard; Smyth Mark J; Johnstone Ricky W
Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells.
International journal of cancer. Journal international du cancer 2002;99(2):292-8.
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2002: Johnstone Ricky W
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.
Nature reviews. Drug discovery 2002;1(4):287-99.
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2002: Johnstone Ricky W; Ruefli Astrid A; Lowe Scott W
Apoptosis: a link between cancer genetics and chemotherapy.
Cell 2002;108(2):153-64.
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2001: Ruefli A A; Ausserlechner M J; Bernhard D; Sutton V R; Tainton K M; Kofler R; Smyth M J; Johnstone R W
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10833-8.
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2001: Clarke C J; Trapani J A; Johnstone R W
Mechanisms of interferon mediated anti-viral resistance.
Current drug targets. Immune, endocrine and metabolic disorders 2001;1(2):117-30.
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2001: Johnstone R W; Tainton K M; Ruefli A A; Froelich C J; Cerruti L; Jane S M; Smyth M J
P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins.
The Journal of biological chemistry 2001;276(20):16667-73.
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2000: Browne K A; Johnstone R W; Jans D A; Trapani J A
Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis.
The Journal of biological chemistry 2000;275(50):39262-6.
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2000: Sutton V R; Davis J E; Cancilla M; Johnstone R W; Ruefli A A; Sedelies K; Browne K A; Trapani J A
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.
The Journal of experimental medicine 2000;192(10):1403-14.
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2000: Tainton K M; Ruefli A A; Smyth M J; Johnstone R W
Equivalent death of P-glycoprotein expressing and nonexpressing cells induced by the protein kinase C inhibitor staurosporine.
Biochemical and biophysical research communications 2000;276(1):231-7.
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2000: Johnstone R W; Ruefli A A; Tainton K M; Smyth M J
A role for P-glycoprotein in regulating cell death.
Leukemia & lymphoma 2000;38(1-2):1-11.
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2000: Ruefli A A; Smyth M J; Johnstone R W
HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance.
Blood 2000;95(7):2378-85.
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2000: Johnstone R W; Ruefli A A; Smyth M J
Multiple physiological functions for multidrug transporter P-glycoprotein?
Trends in biochemical sciences 2000;25(1):1-6.
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1999: Johnstone R W; Trapani J A
Transcription and growth regulatory functions of the HIN-200 family of proteins.
Molecular and cellular biology 1999;19(9):5833-8.
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1998: Johnstone R W; Kershaw M H; Trapani J A
Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing.
Biochemistry 1998;37(34):11924-31.
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1998: Johnstone R W; Kerry J A; Trapani J A
The human interferon-inducible protein, IFI 16, is a repressor of transcription.
The Journal of biological chemistry 1998;273(27):17172-7.
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1998: Smyth M J; Krasovskis E; Johnstone R W
Fas ligand-mediated lysis of self bystander targets by human papillomavirus-specific CD8+ cytotoxic T lymphocytes.
Journal of virology 1998;72(7):5948-54.
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1998: Smyth M J; Krasovskis E; Sutton V R; Johnstone R W
The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7024-9.
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