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Synèse Jolidon

Research Profile

Chemicals & Drugs

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TOP 3
emmanuel pinard; Daniela Alberati; Markus Bender; Edilio Borroni; Virginie Brom; Serge Burner; Holger Fischer; Dominik Hainzl; Remy Halm; Nicole Hauser; Synèse Jolidon; Judith Lengyel; Hans-Peter Marty; Thierry Meyer; Jean-Luc Moreau; Roland Mory; Robert Narquizian; Roger D Norcross; Philipp Schmid; Roger Wermuth; Daniel Zimmerli
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors.
Eric Vieira; Jörg Huwyler; Synèse Jolidon; Frédéric Knoflach; Vincent Mutel; Jürgen Wichmann
Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers.
Synèse Jolidon; Daniela Alberati; Adam Dowle; Holger Fischer; Dominik Hainzl; Robert Narquizian; Roger Norcross; Emmanuel Pinard
Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1.

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All Publications

2010: emmanuel pinard; Daniela Alberati; Markus Bender; Edilio Borroni; Virginie Brom; Serge Burner; Holger Fischer; Dominik Hainzl; Remy Halm; Nicole Hauser; Synèse Jolidon; Judith Lengyel; Hans-Peter Marty; Thierry Meyer; Jean-Luc Moreau; Roland Mory; Robert Narquizian; Roger D Norcross; Philipp Schmid; Roger Wermuth; Daniel Zimmerli
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(23):6960-5.
2009: Eric Vieira; Jörg Huwyler; Synèse Jolidon; Frédéric Knoflach; Vincent Mutel; Jürgen Wichmann
Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers.
Bioorganic & medicinal chemistry letters 2009;19(6):1666-9.
2008: Synèse Jolidon; Daniela Alberati; Adam Dowle; Holger Fischer; Dominik Hainzl; Robert Narquizian; Roger Norcross; Emmanuel Pinard
Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1.
Bioorganic & medicinal chemistry letters 2008;18(20):5533-6.
2008: emmanuel pinard; Daniela Alberati; Edilio Borroni; Holger Fischer; Dominik Hainzl; Synèse Jolidon; Jean-Luc Moreau; Robert Narquizian; Matthias Nettekoven; Roger D Norcross; Henri Stalder; Andrew W Thomas
Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(18):5134-9.
2006: Daniela Alberati; Dominik Hainzl; Synèse Jolidon; Anke Kurt; emmanuel pinard; Andrew W Thomas; Daniel Zimmerli
4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters.
Bioorganic & medicinal chemistry letters 2006;16(16):4321-5.
2006: Daniela Alberati; Simona M Ceccarelli; Synèse Jolidon; Eva A Krafft; Anke Kurt; Axel Maier; emmanuel pinard; Henri Stalder; Deborah Studer; Andrew W Thomas; Daniel Zimmerli
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: achieving selectivity against the mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors.
Bioorganic & medicinal chemistry letters 2006;16(16):4305-10.
2006: Daniela Alberati; Dominik Hainzl; Synèse Jolidon; Eva A Krafft; Anke Kurt; Axel Maier; emmanuel pinard; Andrew W Thomas; Daniel Zimmerli
Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability.
Bioorganic & medicinal chemistry letters 2006;16(16):4311-5.
2005: Eric Vieira; Jörg Huwyler; Synèse Jolidon; Frédéric Knoflach; Vincent Mutel; Jürgen Wichmann
9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers.
Bioorganic & medicinal chemistry letters 2005;15(20):4628-31.
2003: Henrietta Dehmlow; Johannes D Aebi; Synèse Jolidon; Yu-Hua Ji; Elisabeth M von der Mark; Jacques Himber; Olivier H Morand
Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors.
Journal of medicinal chemistry 2003;46(15):3354-70.
2001: Frédéric Knoflach; Vincent Mutel; Synèse Jolidon; James N C Kew; Pari Malherbe; Eric Vieira; Jürgen Wichmann; John A Kemp
Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13402-7.