FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Hassan Jomaa

Research Profile

Chemicals & Drugs

Co-author Network

Publications

TOP 3
Natalia Soriano-Sarabia; Gregor Bein; Hassan Jomaa; Thomas Kubin; Hakon Sandvold; Holger Hackstein
Primary MHC-class II(+) cells are necessary to promote resting Vδ2 cell expansion in response to (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate and isopentenyl pyrophosphate.
Ingo Rekittke; Hassan Jomaa; Ulrich Ermler
Structure of the GcpE (IspG)-MEcPP complex from Thermus thermophilus.
Nadine E Englert; Christian Richter; Jochen Wiesner; Martin Hintz; Hassan Jomaa; Harald Schwalbe
NMR studies of DOXP reductoisomerase and its inhibitor complex.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Hassan Jomaa (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Natalia Soriano-Sarabia; Gregor Bein; Hassan Jomaa; Thomas Kubin; Hakon Sandvold; Holger Hackstein
Primary MHC-class II(+) cells are necessary to promote resting Vδ2 cell expansion in response to (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate and isopentenyl pyrophosphate.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(11):5212-22.
2012: Ingo Rekittke; Hassan Jomaa; Ulrich Ermler
Structure of the GcpE (IspG)-MEcPP complex from Thermus thermophilus.
FEBS letters 2012;586(19):3452-7.
2011: Nadine E Englert; Christian Richter; Jochen Wiesner; Martin Hintz; Hassan Jomaa; Harald Schwalbe
NMR studies of DOXP reductoisomerase and its inhibitor complex.
Chembiochem : a European journal of chemical biology 2011;12(3):468-76.
2011: Ingo Rekittke; Tsuyoshi Nonaka; Jochen Wiesner; Ulrike Demmer; Eberhard Warkentin; Hassan Jomaa; Ulrich Ermler
Structure of the E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) from Thermus thermophilus.
FEBS letters 2011;585(3):447-51.
2011: Stefan Baumeister; Jochen Wiesner; Armin Reichenberg; Martin Hintz; Sven Bietz; Omar S Harb; David S Roos; Maximilian Kordes; Johannes Friesen; Kai Matuschewski; Klaus Lingelbach; Hassan Jomaa; Frank Seeber
Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways.
PloS one 2011;6(5):e19334.
2010: Weiya Xu; Nicholas S Lees; Dolapo Adedeji; Jochen Wiesner; Hassan Jomaa; Brian M Hoffman; Evert C Duin
Paramagnetic intermediates of (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE/IspG) under steady-state and pre-steady-state conditions.
Journal of the American Chemical Society 2010;132(41):14509-20.
2010: Feng Yan; Jacqueline M LaMarre; Rene Röhrich; Jochen Wiesner; Hassan Jomaa; Alexander S Mankin; Danica Galonic Fujimori
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA.
Journal of the American Chemical Society 2010;132(11):3953-64.
2009: Zahida Ali; Lin Yan; Nicholas Plagman; Armin Reichenberg; Martin Hintz; Hassan Jomaa; Francios VILLINGER; Zheng W Chen
Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5407-17.
2009: Dan Huang; Crystal Y Chen; Zahida Ali; Lingyun Shao; Ling Shen; Hank A Lockman; Roy E Barnewall; Carol Sabourin; James Eestep; Armin Reichenberg; Martin Hintz; Hassan Jomaa; Richard Wang; Zheng W Chen
Antigen-specific Vgamma2Vdelta2 T effector cells confer homeostatic protection against pneumonic plaque lesions.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7553-8.
2008: Ingo Rekittke; Jochen Wiesner; Rene Röhrich; Ulrike Demmer; Eberhard Warkentin; Weiya Xu; Kathrin Troschke; Martin Hintz; Joo Hwan No; Evert C Duin; Eric Oldfield; Hassan Jomaa; Ulrich Ermler
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway.
Journal of the American Chemical Society 2008;130(51):17206-7.
2008: Máire Begley; Peter A Bron; Sinead Heuston; Pat G Casey; Nadine Englert; Jochen Wiesner; Hassan Jomaa; Cormac G M Gahan; Colin Hill
Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection.
Infection and immunity 2008;76(11):5392-401.
2008: Katja Kohring; Jochen Wiesner; Mirko Altenkämper; Jacek Sakowski; Katrin Silber; Alexander Hillebrecht; Peter Haebel; Hans-Martin Dahse; Regina Ortmann; Hassan Jomaa; Gerhard Klebe; Martin Schlitzer
Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials.
ChemMedChem 2008;3(8):1217-31.
2008: Johann Perruchon; Regina Ortmann; Mirko Altenkämper; Katrin Silber; Jochen Wiesner; Hassan Jomaa; Gerhard Klebe; Martin Schlitzer
Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase.
ChemMedChem 2008;3(8):1232-41.
2008: Dirk Giessmann; Philipp Heidler; Timothy Haemers; Serge Van Calenbergh; Armin Reichenberg; Hassan Jomaa; Claus Weidemeyer; Silke Sanderbrand; Jochen Wiesner; Andreas Link
Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
Chemistry & biodiversity 2008;5(4):643-56.
2008: Timothy Haemers; Jochen Wiesner; Dirk Giessmann; Thomas Verbrugghen; Ulrik Hillaert; Regina Ortmann; Hassan Jomaa; Andreas Link; Martin Schlitzer; Serge Van Calenbergh
Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates.
Bioorganic & medicinal chemistry 2008;16(6):3361-71.
2008: Steven Van Hoof; Carl Jeffrey Lacey; René C Röhrich; Jochen Wiesner; Hassan Jomaa; Serge Van Calenbergh
Synthesis of analogues of (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate, an isoprenoid precursor and human gamma delta T cell activator.
The Journal of organic chemistry 2008;73(4):1365-70.
2008: Jochen Wiesner; Armin Reichenberg; S Heinrich; Martin Schlitzer; Hassan Jomaa
The plastid-like organelle of apicomplexan parasites as drug target.
Current pharmaceutical design 2008;14(9):855-71.
2007: Zahida Ali; Lingyun Shao; Lisa Halliday; Armin Reichenberg; Martin Hintz; Hassan Jomaa; Zheng W Chen
Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(12):8287-96.
2007: Jochen Wiesner; Regina Ortmann; Hassan Jomaa; Martin Schlitzer
Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity.
Archiv der Pharmazie 2007;340(12):667-9.
2007: Andrey A Fokin; Alexander G Yurchenko; Vladimir N Rodionov; Pavel A Gunchenko; Raisa I Yurchenko; Armin Reichenberg; Jochen Wiesner; Martin Hintz; Hassan Jomaa; Peter R Schreiner
Synthesis of the antimalarial drug FR900098 utilizing the nitroso-ene reaction.
Organic letters 2007;9(21):4379-82.
2007: Regina Ortmann; Jochen Wiesner; Katrin Silber; Gerhard Klebe; Hassan Jomaa; Martin Schlitzer
Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues.
Archiv der Pharmazie 2007;340(9):483-90.
2007: Vincent Devreux; Jochen Wiesner; Hassan Jomaa; Johan Van der Eycken; Serge Van Calenbergh
Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(17):4920-3.
2007: Dominik Burkhardt; Jochen Wiesner; Nicole Stoesser; Michael Ramharter; Anne-Catrin Uhlemann; Saadou Issifou; Hassan Jomaa; Sanjeev Krishna; Song Le; Steffen Borrmann
Delayed parasite elimination in human infections treated with clindamycin parallels 'delayed death' of Plasmodium falciparum in vitro.
International journal for parasitology 2007;37(7):777-85.
2007: Vincent Devreux; Jochen Wiesner; Hassan Jomaa; Jef Rozenski; Johan Van der Eycken; Serge Van Calenbergh
Divergent strategy for the synthesis of alpha-aryl-substituted fosmidomycin analogues.
The Journal of organic chemistry 2007;72(10):3783-9.
2007: Marina Zafranskaya; Patrick Oschmann; Rosel Engel; Andreas Weishaupt; Johannes M van Noort; Hassan Jomaa; Matthias Eberl
Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis.
Immunology 2007;121(1):29-39.
2007: David Vermijlen; Peter Ellis; Cordelia Langford; Anne Klein; Rosel Engel; Katharina Willimann; Hassan Jomaa; Adrian C Hayday; Matthias Eberl
Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4304-14.
2007: Dolapo Adedeji; Heather Hernandez; Jochen Wiesner; Uwe Köhler; Hassan Jomaa; Evert C Duin
Possible direct involvement of the active-site [4Fe-4S] cluster of the GcpE enzyme from Thermus thermophilus in the conversion of MEcPP.
FEBS letters 2007;581(2):279-83.
2007: Jochen Wiesner; Hassan Jomaa
Isoprenoid biosynthesis of the apicoplast as drug target.
Current drug targets 2007;8(1):3-13.
2006: Steffen Borrmann; Ingrid Lundgren; Sunny Oyakhirome; Bénido Impouma; Pierre-Blaise Matsiegui; Ayola A Adegnika; Saadou Issifou; Jürgen Kun; David Hutchinson; Jochen Wiesner; Hassan Jomaa; Song Le
Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria.
Antimicrobial agents and chemotherapy 2006;50(8):2713-8.
2006: Vincent Devreux; Jochen Wiesner; Jan Goeman; Johan Van der Eycken; Hassan Jomaa; Serge Van Calenbergh
Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors.
Journal of medicinal chemistry 2006;49(8):2656-60.
2006: Nadia Caccamo; Francesco Dieli; Daniela Wesch; Hassan Jomaa; Matthias Eberl
Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells.
Journal of leukocyte biology 2006;79(4):663-6.
2006: Timothy Haemers; Jochen Wiesner; Sara Van Poecke; Jan Goeman; Dajana Henschker; Ewald Beck; Hassan Jomaa; Serge Van Calenbergh
Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(7):1888-91.
2006: Katja Kettler; Jochen Wiesner; Regina Ortmann; Hans-Martin Dahse; Hassan Jomaa; Martin Schlitzer
Antimalarial activity of methylpiperazinyl-substituted benzophenone-based farnesyltransferase inhibitors.
Die Pharmazie 2006;61(1):63-5.
2005: René C Röhrich; Nadine Englert; Katrin Troschke; Armin Reichenberg; Martin Hintz; Frank Seeber; Emanuela Balconi; Alessandro Aliverti; Giuliana Zanetti; Uwe Köhler; Matthias Pfeiffer; Ewald Beck; Hassan Jomaa; Jochen Wiesner
Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum.
FEBS letters 2005;579(28):6433-8.
2005: Katja Kettler; Jochen Wiesner; Katharina Fucik; Jacek Sakowski; Regina Ortmann; Hans-Martin Dahse; Hassan Jomaa; Martin Schlitzer
2-(aminoacylamino)benzophenones: farnesyltransferase inhibition and antimalarial activity.
Die Pharmazie 2005;60(9):677-82.
2005: Steffen Borrmann; Ayola A Adegnika; Félicien Moussavou; Sunny Oyakhirome; Gilbert Esser; Pierre-Blaise Matsiegui; Michael Ramharter; Ingrid Lundgren; Maryvonne Kombila; Saadou Issifou; David Hutchinson; Jochen Wiesner; Hassan Jomaa; Song Le
Short-course regimens of artesunate-fosmidomycin in treatment of uncomplicated Plasmodium falciparum malaria.
Antimicrobial agents and chemotherapy 2005;49(9):3749-54.
2005: Regina Ortmann; Jochen Wiesner; Armin Reichenberg; Dajana Henschker; Ewald Beck; Hassan Jomaa; Martin Schlitzer
Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity.
Archiv der Pharmazie 2005;338(7):305-14.
2005: SM Trutko; Lubov V Dorofeeva; Lyudmila I Evtushenko; D N Ostrovskiĭ; Martin Hintz; Jochen Wiesner; Hassan Jomaa; Boris P Baskunov; Vassily K Akimenko
[Isoprenoid pigments in representatives of the family Microbacteriaceae].
Mikrobiologiia 2005;74(3):335-41.
2005: Katja Kettler; Jacek Sakowski; Jochen Wiesner; Regina Ortmann; Hassan Jomaa; Martin Schlitzer
Novel lead structures for antimalarial farnesyltransferase inhibitors.
Die Pharmazie 2005;60(5):323-7.
2005: SM Trutko; Lubov V Dorofeeva; Viktoria Shcherbakova; N A Chuvil'skaia; KS Laurinavichus; VI Biniukov; D N Ostrovskiĭ; Martin Hintz; Jochen Wiesner; Hassan Jomaa; Vassily K Akimenko
[Prevalence of nonmevalonate and mevalonate pathways for isoprenoid biosynthesis among bacteria of different systematic groups].
Mikrobiologiia 2005;74(2):185-90.
2005: Katja Kettler; Jochen Wiesner; Katrin Silber; Peter Haebel; Regina Ortmann; Isabel Sattler; Hans-Martin Dahse; Hassan Jomaa; Gerhard Klebe; Martin Schlitzer
Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity.
European journal of medicinal chemistry 2005;40(1):93-101.
2005: Matthias Eberl; Rosel Engel; Silke Aberle; Paul Fisch; Hassan Jomaa; Hanspeter Pircher
Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1).
Journal of leukocyte biology 2005;77(1):67-70.
2004: Maria Cassera; Fabio C Gozzo; Fabio Luiz D'Alexandri; Emilio F Merino; Hernando A del Portillo; Valnice J Peres; Igor Almeida; Marcos N Eberlin; Gerhard Wunderlich; Jochen Wiesner; Hassan Jomaa; Emilia A Kimura; Alejandro M Katzin
The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum.
The Journal of biological chemistry 2004;279(50):51749-59.
2004: Steffen Borrmann; Saadou Issifou; Gilbert Esser; Ayola A Adegnika; Michael Ramharter; Pierre-Blaise Matsiegui; Sunny Oyakhirome; Denise Patricia Mawili Mboumba; Michel A Missinou; Jürgen Kun; Hassan Jomaa; Song Le
Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria.
The Journal of infectious diseases 2004;190(9):1534-40.
2004: Katharina Fucik; Katja Kettler; Jochen Wiesner; Regina Ortmann; Doris Unterreitmeier; Jürgen Krauss; Franz Bracher; Hassan Jomaa; Martin Schlitzer
2-(Arylpropionylamino)- and 2-(arylacryloylamino)benzophenones: farnesyltransferase inhibition and antimalarial activity.
Die Pharmazie 2004;59(10):744-52.
2004: Shunsuke Yajima; Kodai Hara; John M Sanders; Fenglin Yin; Kanju Ohsawa; Jochen Wiesner; Hassan Jomaa; Eric Oldfield
Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes.
Journal of the American Chemical Society 2004;126(35):10824-5.
2004: Matthias Eberl; Martin Hintz; Zandraa Jamba; Ewald Beck; Hassan Jomaa; Gunna Christiansen
Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so.
Infection and immunity 2004;72(8):4881-3.
2004: Stéphane Bronner; Corinne Renault; Martin Hintz; Jochen Wiesner; Hassan Jomaa; Henri Monteil; François Jehl
Determination of fosmidomycin in human serum and urine by capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;806(2):255-61.
2004: Matthias Eberl; Hassan Jomaa; Adrian C Hayday
Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells.
Immunology 2004;112(3):364-8.
2004: Máire Begley; Cormac G M Gahan; Ann-Kristin Kollas; Martin Hintz; Colin Hill; Hassan Jomaa; Matthias Eberl
The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes.
FEBS letters 2004;561(1-3):99-104.
2004: Steffen Borrmann; Ayola A Adegnika; Pierre-Blaise Matsiegui; Saadou Issifou; Andreas Schindler; Denise Patricia Mawili Mboumba; Thomas Baranek; Jochen Wiesner; Hassan Jomaa; Song Le
Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children.
The Journal of infectious diseases 2004;189(5):901-8.
2004: Claudia Herforth; Jochen Wiesner; Philipp Heidler; Silke Sanderbrand; Serge Van Calenbergh; Hassan Jomaa; Andreas Link
Antimalarial activity of N(6)-substituted adenosine derivatives. Part 3.
Bioorganic & medicinal chemistry 2004;12(4):755-62.
2004: Jochen Wiesner; Katja Kettler; Jacek Sakowski; Regina Ortmann; Alejandro M Katzin; Emilia A Kimura; Katrin Silber; Gerhard Klebe; Hassan Jomaa; Martin Schlitzer
Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo.
Angewandte Chemie (International ed. in English) 2004;43(2):251-4.
2003: Jochen Wiesner; Andreas Mitsch; M Altenkämper; Regina Ortmann; Hassan Jomaa; Martin Schlitzer
Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity.
Die Pharmazie 2003;58(12):854-6.
2003: Jochen Wiesner; Regina Ortmann; Hassan Jomaa; Martin Schlitzer
New antimalarial drugs.
Angewandte Chemie (International ed. in English) 2003;42(43):5274-93.
2003: Matthias Eberl; Hassan Jomaa
A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens.
Trends in immunology 2003;24(8):407-9.
2003: Regina Ortmann; Jochen Wiesner; Armin Reichenberg; Dajana Henschker; Ewald Beck; Hassan Jomaa; Martin Schlitzer
Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity.
Bioorganic & medicinal chemistry letters 2003;13(13):2163-6.
2003: Jochen Wiesner; Andreas Mitsch; Hassan Jomaa; Martin Schlitzer
Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties.
Bioorganic & medicinal chemistry letters 2003;13(13):2159-61.
2003: Matthias Eberl; Martin Hintz; Armin Reichenberg; Ann-Kristin Kollas; Jochen Wiesner; Hassan Jomaa
Microbial isoprenoid biosynthesis and human gammadelta T cell activation.
FEBS letters 2003;544(1-3):4-10.
2003: Jochen Wiesner; Steffen Borrmann; Hassan Jomaa
Fosmidomycin for the treatment of malaria.
Parasitology research 2003;90 Suppl 2():S71-6.
2003: Jochen Wiesner; Katharina Fucik; Katja Kettler; Jacek Sakowski; Regina Ortmann; Hassan Jomaa; Martin Schlitzer
Structure-activity relationships of novel anti-malarial agents. Part 6: N-(4-arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.
Bioorganic & medicinal chemistry letters 2003;13(9):1539-41.
2003: Armin Reichenberg; Martin Hintz; Yvonne Kletschek; Tanja Kuhl; Christian Haug; Rosel Engel; Jens Moll; Dmitry N Ostrovsky; Hassan Jomaa; Matthias Eberl
Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism.
Bioorganic & medicinal chemistry letters 2003;13(7):1257-60.
2003: Jochen Wiesner; Regina Ortmann; Andreas Mitsch; Pia Wissner; Isabel Sattler; Hassan Jomaa; Martin Schlitzer
Inhibitors of farnesyltransferase: 5-arylacryloylaminobenzophenones show antimalarial activity.
Die Pharmazie 2003;58(4):289-90.
2003: Jochen Wiesner; Katja Kettler; Jacek Sakowski; Regina Ortmann; Hassan Jomaa; Martin Schlitzer
Structure-activity relationships of novel anti-malarial agents: part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.
Bioorganic & medicinal chemistry letters 2003;13(3):361-3.
2003: Bertrand Lell; Ronnatrai Ruangweerayut; Jochen Wiesner; Michel A Missinou; Andreas Schindler; Thomas Baranek; Martin Hintz; David Hutchinson; Hassan Jomaa; Song Le
Fosmidomycin, a novel chemotherapeutic agent for malaria.
Antimicrobial agents and chemotherapy 2003;47(2):735-8.
2002: Boran Altincicek; Evert C Duin; Armin Reichenberg; Reiner Hedderich; Ann-Kristin Kollas; Martin Hintz; Stefanie Wagner; Jochen Wiesner; Ewald Beck; Hassan Jomaa
LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis.
FEBS letters 2002;532(3):437-40.
2002: Ann-Kristin Kollas; Evert C Duin; Matthias Eberl; Boran Altincicek; Martin Hintz; Armin Reichenberg; Dajana Henschker; Anke Henne; Irina Steinbrecher; Dmitry N Ostrovsky; Reiner Hedderich; Ewald Beck; Hassan Jomaa; Jochen Wiesner
Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis.
FEBS letters 2002;532(3):432-6.
2002: Michel A Missinou; Steffen Borrmann; Andreas Schindler; Saadou Issifou; Ayola A Adegnika; Pierre-Blaise Matsiegui; Ronald K Binder; Bertrand Lell; Jochen Wiesner; Thomas Baranek; Hassan Jomaa; Song Le
Fosmidomycin for malaria.
Lancet 2002;360(9349):1941-2.
2002: Jochen Wiesner; Andreas Mitsch; Pia Wissner; Oliver Krämer; Hassan Jomaa; Martin Schlitzer
Structure-activity relationships of novel anti-malarial agents. Part 4: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides.
Bioorganic & medicinal chemistry letters 2002;12(19):2681-3.
2002: Jochen Wiesner; Dajana Henschker; David B Hutchinson; Ewald Beck; Hassan Jomaa
In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin.
Antimicrobial agents and chemotherapy 2002;46(9):2889-94.
2002: Matthias Eberl; Rosel Engel; Ewald Beck; Hassan Jomaa
Differentiation of human gamma-delta T cells towards distinct memory phenotypes.
Cellular immunology 2002;218(1-2):1-6.
2002: Claudia Herforth; Jochen Wiesner; Stephan Franke; Abolfasl Golisade; Hassan Jomaa; Andreas Link
Antimalarial activity of n(6)-substituted adenosine derivatives (part 2).
Journal of combinatorial chemistry 2002;4(4):302-14.
2002: Matthias Eberl; Boran Altincicek; Ann-Kristin Kollas; Silke Sanderbrand; Ute Bahr; Armin Reichenberg; Ewald Beck; Donald Foster; Jochen Wiesner; Martin Hintz; Hassan Jomaa
Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli.
Immunology 2002;106(2):200-11.
2002: Abolfasl Golisade; Jochen Wiesner; Claudia Herforth; Hassan Jomaa; Andreas Link
Anti-malarial activity of N(6)-substituted adenosine derivatives. Part I.
Bioorganic & medicinal chemistry 2002;10(3):769-77.
2002: Jochen Wiesner; Katja Kettler; Hassan Jomaa; Martin Schlitzer
Structure-activity relationships of novel anti-malarial agents. Part 3: N-(4-acylamino-3-benzoylphenyl)-4-propoxycinnamic acid amides.
Bioorganic & medicinal chemistry letters 2002;12(4):543-5.
2002: Klaus Reuter; Silke Sanderbrand; Hassan Jomaa; Jochen Wiesner; Irina Steinbrecher; Ewald Beck; Martin Hintz; Gerhard Klebe; Milton T Stubbs
Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis.
The Journal of biological chemistry 2002;277(7):5378-84.
2001: Martin Hintz; Armin Reichenberg; Boran Altincicek; Ute Bahr; R M Gschwind; Ann-Kristin Kollas; Ewald Beck; Jochen Wiesner; Matthias Eberl; Hassan Jomaa
Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli.
FEBS letters 2001;509(2):317-22.
2001: Boran Altincicek; Ann-Kristin Kollas; Matthias Eberl; Jochen Wiesner; Silke Sanderbrand; Martin Hintz; Ewald Beck; Hassan Jomaa
LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.
FEBS letters 2001;499(1-2):37-40.
2001: Jochen Wiesner; Andreas Mitsch; Pia Wissner; Hassan Jomaa; Martin Schlitzer
Structure-activity relationships of novel anti-malarial agents: 1. arylacyl and cyclohexylacyl derivatives of 5-amino-2-tolylacetylaminobenzophenone.
Die Pharmazie 2001;56(6):443-4.
2001: Boran Altincicek; Ann-Kristin Kollas; Silke Sanderbrand; Jochen Wiesner; Martin Hintz; Ewald Beck; Hassan Jomaa
GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.
Journal of bacteriology 2001;183(8):2411-6.
2001: Armin Reichenberg; Jochen Wiesner; C Weidemeyer; E Dreiseidler; Silke Sanderbrand; Boran Altincicek; Ewald Beck; Martin Schlitzer; Hassan Jomaa
Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity.
Bioorganic & medicinal chemistry letters 2001;11(6):833-5.
2001: Boran Altincicek; J Moll; Narciso Campos; G Foerster; Ewald Beck; Jean-François Hoeffler; Catherine Grosdemange-Billiard; Manuel Rodríguez-Concepción; Marie-Madeleine Rohmer; Albert Boronat; Matthias Eberl; Hassan Jomaa
Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3655-8.
2001: Jochen Wiesner; Pia Wissner; Hans-Martin Dahse; Hassan Jomaa; Martin Schlitzer
Discovery of a novel lead structure for anti-malarials.
Bioorganic & medicinal chemistry 2001;9(3):785-92.
2001: Jochen Wiesner; Andreas Mitsch; Pia Wissner; Hassan Jomaa; Martin Schlitzer
Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives.
Bioorganic & medicinal chemistry letters 2001;11(3):423-4.
2000: Jochen Wiesner; Martin Hintz; Boran Altincicek; Silke Sanderbrand; C Weidemeyer; Ewald Beck; Hassan Jomaa
Plasmodium falciparum: detection of the deoxyxylulose 5-phosphate reductoisomerase activity.
Experimental parasitology 2000;96(3):182-6.
2000: Boran Altincicek; Martin Hintz; Silke Sanderbrand; Jochen Wiesner; Ewald Beck; Hassan Jomaa
Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa.
FEMS microbiology letters 2000;190(2):329-33.
1999: Hassan Jomaa; Jochen Wiesner; Silke Sanderbrand; Boran Altincicek; C Weidemeyer; Martin Hintz; I Türbachova; Matthias Eberl; J Zeidler; Hartmut K Lichtenthaler; D Soldati; Ewald Beck
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs.
Science (New York, N.Y.) 1999;285(5433):1573-6.