FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Patricia Babbitt

Research Profile

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Phenomena

Chemicals & Drugs

Procedures

Occupations

Computational Biology

Living Beings

Escherichia coli

Co-author Network

Publications

TOP 3
Frank H Wallrapp; Gurusankar Ramamoorthy; Ronald Seidel; Steven C Almo; Daniel Almonacid; Patricia C Babbitt; Brandan S Hillerich; Matthew P Jacobson; Jian-Jung Pan; Yury Patskovsky; C Dale Poulter
Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily.
Tiit Lukk; Satish K Nair; Yury Patskovsky; Ayano Sakai; Ronald Seidel; Ling Song; Rafael Toro; Matthew W Vetting; Steven C Almo; Patricia C Babbitt; Shoshana D Brown; Alexander A Fedorov; Elena V Fedorov; John Alan Gerlt; Brandan S. Hillerich; Heidi J Imker; Chakrapani Kalyanaraman; Matthew P Jacobson
Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily.
Susan T Mashiyama; James H McKerrow; Conor R Caffrey; Kyriacos Koupparis; Patricia C Babbitt
A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Patricia Babbitt (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Frank H Wallrapp; Gurusankar Ramamoorthy; Ronald Seidel; Steven C Almo; Daniel Almonacid; Patricia C Babbitt; Brandan S Hillerich; Matthew P Jacobson; Jian-Jung Pan; Yury Patskovsky; C Dale Poulter
Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(13):E1196-202.
2012: Tiit Lukk; Satish K Nair; Yury Patskovsky; Ayano Sakai; Ronald Seidel; Ling Song; Rafael Toro; Matthew W Vetting; Steven C Almo; Patricia C Babbitt; Shoshana D Brown; Alexander A Fedorov; Elena V Fedorov; John Alan Gerlt; Brandan S. Hillerich; Heidi J Imker; Chakrapani Kalyanaraman; Matthew P Jacobson
Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(11):4122-7.
2012: Susan T Mashiyama; James H McKerrow; Conor R Caffrey; Kyriacos Koupparis; Patricia C Babbitt
A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets.
PLoS neglected tropical diseases 2012;6(12):e1942.
2011: John Alan Gerlt; Heidi J Imker; Matthew P Jacobson; Wladek Minor; C Dale Poulter; Frank M Raushel; Andrej Sali; Brian K Shoichet; Karen N Allen; Steven C Almo; Richard N Armstrong; Patricia C Babbitt; John E Cronan; Debra Dunaway-Mariano; Jonathan V Sweedler
The Enzyme Function Initiative.
Biochemistry 2011;50(46):9950-62.
2011: Michael A Hicks; Sarah E O'Connor; Alan E Barber; Jenna Caldwell; Lesley-Ann Giddings; Patricia C Babbitt
The evolution of function in strictosidine synthase-like proteins.
Proteins 2011;79(11):3082-98.
2011: Daniel Almonacid; Patricia C Babbitt
Toward mechanistic classification of enzyme functions.
Current opinion in chemical biology 2011;15(3):435-42.
2011: Elaine C Meng; Patricia C Babbitt
Topological variation in the evolution of new reactions in functionally diverse enzyme superfamilies.
Current opinion in structural biology 2011;21(3):391-7.
2011: Leonard Apeltsin; John H Morris; Patricia C Babbitt; Thomas E Ferrin
Improving the quality of protein similarity network clustering algorithms using the network edge weight distribution.
Bioinformatics (Oxford, England) 2011;27(3):326-33.
2010: Daniel Almonacid; Emmanuel R Yera; John Mitchell; Patricia C Babbitt
Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes: implications for classification of enzyme function.
PLoS computational biology 2010;6(3):e1000700.
2009: Alexandra M Schnoes; Shoshana D Brown; Igor Dodevski; Patricia C Babbitt
Annotation error in public databases: misannotation of molecular function in enzyme superfamilies.
PLoS computational biology 2009;5(12):e1000605.
2009: Holly J Atkinson; Patricia C Babbitt; Mohammed Sajid
The global cysteine peptidase landscape in parasites.
Trends in parasitology 2009;25(12):573-81.
2009: Holly J Atkinson; Patricia C Babbitt
Glutathione transferases are structural and functional outliers in the thioredoxin fold.
Biochemistry 2009;48(46):11108-16.
2009: Holly J Atkinson; Patricia C Babbitt
An atlas of the thioredoxin fold class reveals the complexity of function-enabling adaptations.
PLoS computational biology 2009;5(10):e1000541.
2009: James Corey Adams; Michael J Keiser; Li Basuino; Henry F Chambers; Deok-Sun Lee; Olaf G Wiest; Patricia C Babbitt
A mapping of drug space from the viewpoint of small molecule metabolism.
PLoS computational biology 2009;5(8):e1000474.
2009: Jennifer A Cummings; Alexander A Fedorov; Chengfu Xu; Shoshana Brown; Elena V Fedorov; Patricia C Babbitt; Steven C Almo; Frank M Raushel
Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily.
Biochemistry 2009;48(27):6469-81.
2009: Mark E Peterson; Feng Chen; Jeffery G Saven; David S Roos; Patricia C Babbitt; Andrej Sali
Evolutionary constraints on structural similarity in orthologs and paralogs.
Protein science : a publication of the Protein Society 2009;18(6):1306-15.
2009: Ursula Pieper; Ranyee Chiang; Jennifer J Seffernick; Shoshana D Brown; Margaret E Glasner; Libusha Kelly; Narayanan Eswar; J Michael Sauder; Jeffrey B Bonanno; Subramanyam Swaminathan; Stephen K Burley; Xiaojing Zheng; Mark R Chance; Steven C Almo; John Alan Gerlt; Frank M Raushel; Matthew P Jacobson; Patricia C Babbitt; Andrej Sali
Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies.
Journal of structural and functional genomics 2009;10(2):107-25.
2009: Ayano Sakai; Alexander A Fedorov; Elena V Fedorov; Alexandra M Schnoes; Margaret E Glasner; Shoshana Brown; Marc E Rutter; Kevin Bain; Shawn Chang; Tarun Gheyi; J Michael Sauder; Stephen K Burley; Patricia C Babbitt; Steven C Almo; John Alan Gerlt
Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes.
Biochemistry 2009;48(7):1445-53.
2009: John Alan Gerlt; Patricia C Babbitt
Enzyme (re)design: lessons from natural evolution and computation.
Current opinion in chemical biology 2009;13(1):10-8.
2009: Jan Dvorák; Susan T Mashiyama; Mohammed Sajid; Simon Braschi; Melaine Delcroix; Eric L Schneider; Wilson H McKerrow; Mahmoud Bahgat; Elizabeth Hansell; Patricia C Babbitt; Charles S Craik; James H McKerrow; Conor R Caffrey
SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni.
PLoS neglected tropical diseases 2009;3(6):e449.
2009: Holly J Atkinson; John H Morris; Thomas E Ferrin; Patricia C Babbitt
Using sequence similarity networks for visualization of relationships across diverse protein superfamilies.
PloS one 2009;4(2):e4345.
2008: Chakrapani Kalyanaraman; Heidi J Imker; Alexander A Fedorov; Elena V Fedorov; Margaret E Glasner; Patricia C Babbitt; Steven C Almo; John Alan Gerlt; Matthew P Jacobson
Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening.
Structure (London, England : 1993) 2008;16(11):1668-77.
2008: John F Rakus; Alexander A Fedorov; Elena V Fedorov; Margaret E Glasner; BK Hubbard; Joseph D Delli; Patricia C Babbitt; Steven C Almo; John Alan Gerlt
Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase.
Biochemistry 2008;47(38):9944-54.
2008: Josef Dvorák; Susan T Mashiyama; Simon Braschi; Mohammed Sajid; Giselle M Knudsen; Elizabeth Hansell; Kee-Chong Lim; Ivy Hsieh; Mahmoud Bahgat; Bryony Mackenzie; Katalin F Medzihradszky; Patricia C Babbitt; Conor R Caffrey; James H McKerrow
Differential use of protease families for invasion by schistosome cercariae.
Biochimie 2008;90(2):345-58.
2008: Tinh T Nguyen; Shoshana Brown; Alexander A Fedorov; Elena V Fedorov; Patricia C Babbitt; Steven C Almo; Frank M Raushel
At the periphery of the amidohydrolase superfamily: Bh0493 from Bacillus halodurans catalyzes the isomerization of D-galacturonate to D-tagaturonate.
Biochemistry 2008;47(4):1194-206.
2008: Ranyee A Chiang; Andrej Sali; Patricia C Babbitt
Evolutionarily conserved substrate substructures for automated annotation of enzyme superfamilies.
PLoS computational biology 2008;4(8):e1000142.
2007: John F Rakus; Alexander A Fedorov; Elena V Fedorov; Margaret E Glasner; Jacob E Vick; Patricia C Babbitt; Steven C Almo; John Alan Gerlt
Evolution of enzymatic activities in the enolase superfamily: D-Mannonate dehydratase from Novosphingobium aromaticivorans.
Biochemistry 2007;46(45):12896-908.
2007: John H Morris; Conrad C Huang; Patricia C Babbitt; Thomas E Ferrin
structureViz: linking Cytoscape and UCSF Chimera.
Bioinformatics (Oxford, England) 2007;23(17):2345-7.
2007: Ling Song; Chakrapani Kalyanaraman; Alexander A Fedorov; Elena V Fedorov; Margaret E Glasner; Shoshana Brown; Heidi J Imker; Patricia C Babbitt; Steven C Almo; Matthew P Jacobson; John Alan Gerlt
Prediction and assignment of function for a divergent N-succinyl amino acid racemase.
Nature chemical biology 2007;3(8):486-91.
2007: Richard Hall; Shoshana Brown; Alexander A Fedorov; Elena V Fedorov; Chengfu Xu; Patricia C Babbitt; Steven C Almo; Frank M Raushel
Structural diversity within the mononuclear and binuclear active sites of N-acetyl-D-glucosamine-6-phosphate deacetylase.
Biochemistry 2007;46(27):7953-62.
2007: Sunil Ojha; Elaine C Meng; Patricia C Babbitt
Evolution of function in the "two dinucleotide binding domains" flavoproteins.
PLoS computational biology 2007;3(7):e121.
2007: Ray A Nagatani; Ana Gonzalez; Brian Shoichet; Linda S Brinen; Patricia C Babbitt
Stability for function trade-offs in the enolase superfamily "catalytic module".
Biochemistry 2007;46(23):6688-95.
2007: Alex S Nord; Karen Vranizan; Whittemore Tingley; Alexander C Zambon; Kristina Hanspers; Loren G Fong; Yan Hu; Peter Bacchetti; Thomas E Ferrin; Patricia C Babbitt; Scott W Doniger; William C Skarnes; Stephen G Young; Bruce R Conklin
Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.
PloS one 2007;2(7):e617.
2007: Margaret E Glasner; John Alan Gerlt; Patricia C Babbitt
Mechanisms of protein evolution and their application to protein engineering.
Advances in enzymology and related areas of molecular biology 2007;75():193-239, xii-xiii.
2006: Margaret E Glasner; John Alan Gerlt; Patricia C Babbitt
Evolution of enzyme superfamilies.
Current opinion in chemical biology 2006;10(5):492-7.
2006: Margaret E Glasner; Nima Fayazmanesh; Ranyee A Chiang; Ayano Sakai; Matthew P Jacobson; John Alan Gerlt; Patricia C Babbitt
Evolution of structure and function in the o-succinylbenzoate synthase/N-acylamino acid racemase family of the enolase superfamily.
Journal of molecular biology 2006;360(1):228-50.
2006: Benjamin J Polacco; Patricia C Babbitt
Automated discovery of 3D motifs for protein function annotation.
Bioinformatics (Oxford, England) 2006;22(6):723-30.
2006: Scott C-H Pegg; Shoshana D Brown; Sunil Ojha; Jennifer L Seffernick; Elaine C Meng; John H Morris; Patricia J Chang; Conrad C Huang; Thomas E Ferrin; Patricia C Babbitt
Leveraging enzyme structure-function relationships for functional inference and experimental design: the structure-function linkage database.
Biochemistry 2006;45(8):2545-55.
2006: Julie Akana; Alexander A Fedorov; Elena V Fedorov; Walter R P Novak; Patricia C Babbitt; Steven C Almo; John Alan Gerlt
D-Ribulose 5-phosphate 3-epimerase: functional and structural relationships to members of the ribulose-phosphate binding (beta/alpha)8-barrel superfamily.
Biochemistry 2006;45(8):2493-503.
2006: Courtney A Harper; Conrad C Huang; Doug Stryke; Michiko Kawamoto; Thomas E Ferrin; Patricia C Babbitt
Comparison of methods for genomic localization of gene trap sequences.
BMC genomics 2006;7():236.
2006: Shoshana D Brown; John Alan Gerlt; Jennifer L Seffernick; Patricia C Babbitt
A gold standard set of mechanistically diverse enzyme superfamilies.
Genome biology 2006;7(1):R8.
2006: Alex S Nord; Patricia J Chang; Bruce R Conklin; Antony V Cox; Courtney A Harper; Geoffrey G Hicks; Conrad C Huang; Susan J Johns; Michiko Kawamoto; Songyan Liu; Elaine C Meng; John H Morris; Janet Rossant; Patricia Ruiz; William C Skarnes; Philippe Soriano; William L Stanford; Doug Stryke; Harald von Melchner; Wolfgang Wurst; Ken-ichi Yamamura; Stephen G Young; Patricia C Babbitt; Thomas E Ferrin
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.
Nucleic acids research 2006;34(Database issue):D642-8.
2005: Scott C-H Pegg; Shoshana Brown; Sunil Ojha; Conrad C Huang; Thomas E Ferrin; Patricia C Babbitt
Representing structure-function relationships in mechanistically diverse enzyme superfamilies.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2005;():358-69.
2005: Patricia C Babbitt; Philip Bourne; Sean D Mooney
Introduction to informatics approaches in structural genomics: modeling and representation of function from macromolecular structure.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2005;():319-21.
2005: John Alan Gerlt; Patricia C Babbitt; Ivan Rayment
Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity.
Archives of biochemistry and biophysics 2005;433(1):59-70.
2004: Shelley D Copley; Walter R P Novak; Patricia C Babbitt
Divergence of function in the thioredoxin fold suprafamily: evidence for evolution of peroxiredoxins from a thioredoxin-like ancestor.
Biochemistry 2004;43(44):13981-95.
2004: Walter R P Novak; Pan-Fen Wang; Michael McLeish; George L Kenyon; Patricia C Babbitt
Isoleucine 69 and valine 325 form a specificity pocket in human muscle creatine kinase.
Biochemistry 2004;43(43):13766-74.
2004: Elaine C Meng; Benjamin J Polacco; Patricia C Babbitt
Superfamily active site templates.
Proteins 2004;55(4):962-76.
2003: Scott C-H Pegg; Walter R P Novak; Patricia C Babbitt
Intersect: identification and visualization of overlaps in database search results.
Bioinformatics (Oxford, England) 2003;19(15):1997-9.
2003: Dawn M Z Schmidt; Emily C Mundorff; Michael Dojka; Ericka Bermudez; Jon E Ness; Sridhar Govindarajan; Patricia C Babbitt; Jeremy Minshull; John Alan Gerlt
Evolutionary potential of (beta/alpha)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily.
Biochemistry 2003;42(28):8387-93.
2003: Patricia C Babbitt
Definitions of enzyme function for the structural genomics era.
Current opinion in chemical biology 2003;7(2):230-7.
2003: Michael McLeish; Malea Kneen; Kota N Gopalakrishna; Carolyn W Koo; Patricia C Babbitt; John Alan Gerlt; George L Kenyon
Identification and characterization of a mandelamide hydrolase and an NAD(P)+-dependent benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633.
Journal of bacteriology 2003;185(8):2451-6.
2003: Shoshana Brown; Jean L Chang; Wolfgang Sadée; Patricia C Babbitt
A semiautomated approach to gene discovery through expressed sequence tag data mining: discovery of new human transporter genes.
AAPS pharmSci 2003;5(1):E1.
2003: Ranyee A Chiang; Elaine C Meng; Conrad C Huang; Thomas E Ferrin; Patricia C Babbitt
The Structure Superposition Database.
Nucleic acids research 2003;31(1):505-10.
2003: Doug Stryke; Michiko Kawamoto; Conrad C Huang; Susan J Johns; Leslie A King; Courtney A Harper; Elaine C Meng; Roy E Lee; Alice Yee; Larry L'Italien; Pao-Tien Chuang; Stephen G Young; William C Skarnes; Patricia C Babbitt; Thomas E Ferrin
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research 2003;31(1):278-81.
2002: Sushmita D Lahiri; Pan-Fen Wang; Patricia C Babbitt; Michael McLeish; George L Kenyon; Karen N Allen
The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg(2+)-NO(3)(-)-creatine transition-state analogue complex.
Biochemistry 2002;41(47):13861-7.
2002: Pan-Fen Wang; Walter R P Novak; John S Cantwell; Patricia C Babbitt; Michael McLeish; George L Kenyon
Expression of Torpedo californica creatine kinase in Escherichia coli and purification from inclusion bodies.
Protein expression and purification 2002;26(1):89-95.
2002: Eric L Wise; Wen Shan Yew; Patricia C Babbitt; John Alan Gerlt; Ivan Rayment
Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase.
Biochemistry 2002;41(12):3861-9.
2001: Lan Huang; Richard Jacob; Scott C-H Pegg; Michael A Baldwin; Ching C Wang; Al L Burlingame; Patricia C Babbitt
Functional assignment of the 20 S proteasome from Trypanosoma brucei using mass spectrometry and new bioinformatics approaches.
The Journal of biological chemistry 2001;276(30):28327-39.
2001: J S Cantwell; Walter R P Novak; Pan-Fen Wang; Michael McLeish; George L Kenyon; Patricia C Babbitt
Mutagenesis of two acidic active site residues in human muscle creatine kinase: implications for the catalytic mechanism.
Biochemistry 2001;40(10):3056-61.
2001: John Alan Gerlt; Patricia C Babbitt
Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies.
Annual review of biochemistry 2001;70():209-46.
2001: D Rey Banatao; Conrad C Huang; Patricia C Babbitt; Russ B Altman; Teri E Klein
ViewFeature: integrated feature analysis and visualization.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2001;():240-50.
2001: John Alan Gerlt; Patricia C Babbitt
Barrels in pieces?
Nature structural biology 2001;8(1):5-7.
2000: Patricia C Babbitt
Reengineering the glutathione S-transferase scaffold: a rational design strategy pays off.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10298-300.
2000: John Alan Gerlt; Patricia C Babbitt
Can sequence determine function?
Genome biology 2000;1(5):REVIEWS0005.
2000: Patricia C Babbitt; John Alan Gerlt
New functions from old scaffolds: how nature reengineers enzymes for new functions.
Advances in protein chemistry 2000;55():1-28.
2000: Conrad C Huang; Walter R P Novak; Patricia C Babbitt; A I Jewett; Thomas E Ferrin; Teri E Klein
Integrated tools for structural and sequence alignment and analysis.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2000;():230-41.
2000: L H Chen; C B White; Patricia C Babbitt; Michael McLeish; G L Kenyon
A comparative study of human muscle and brain creatine kinases expressed in Escherichia coli.
Journal of protein chemistry 2000;19(1):59-66.
1999: Scott C-H Pegg; Patricia C Babbitt
Shotgun: getting more from sequence similarity searches.
Bioinformatics (Oxford, England) 1999;15(9):729-40.
1999: L Xu; Katheryn A Resing; S L Lawson; Patricia C Babbitt; Shelley D Copley
Evidence that pcpA encodes 2,6-dichlorohydroquinone dioxygenase, the ring cleavage enzyme required for pentachlorophenol degradation in Sphingomonas chlorophenolica strain ATCC 39723.
Biochemistry 1999;38(24):7659-69.
1999: DR Palmer; James B Garrett; V Sharma; R Meganathan; Patricia C Babbitt; John Alan Gerlt
Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase.
Biochemistry 1999;38(14):4252-8.
1998: BK Hubbard; M Koch; DR Palmer; Patricia C Babbitt; John Alan Gerlt
Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
Biochemistry 1998;37(41):14369-75.
1998: Andrew Gulick; DR Palmer; Patricia C Babbitt; John Alan Gerlt; Ivan Rayment
Evolution of enzymatic activities in the enolase superfamily: crystal structure of (D)-glucarate dehydratase from Pseudomonas putida.
Biochemistry 1998;37(41):14358-68.
1998: John Alan Gerlt; Patricia C Babbitt
Mechanistically diverse enzyme superfamilies: the importance of chemistry in the evolution of catalysis.
Current opinion in chemical biology 1998;2(5):607-12.
1998: Miriam S Hasson; I Schlichting; J Moulai; K Taylor; William Barrett; G L Kenyon; Patricia C Babbitt; John Alan Gerlt; Gregory A Petsko; Dagmar Ringe
Evolution of an enzyme active site: the structure of a new crystal form of muconate lactonizing enzyme compared with mandelate racemase and enolase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10396-401.
1998: Angela S Baker; M J Ciocci; W W Metcalf; J Kim; Patricia C Babbitt; B L Wanner; Brian M Martin; Debra Dunaway-Mariano
Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis.
Biochemistry 1998;37(26):9305-15.
1997: Patricia C Babbitt; John Alan Gerlt
Understanding enzyme superfamilies. Chemistry As the fundamental determinant in the evolution of new catalytic activities.
The Journal of biological chemistry 1997;272(49):30591-4.
1997: L Zhang; Mark J Dresser; JK Chun; Patricia C Babbitt; Kathleen M Giacomini
Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).
The Journal of biological chemistry 1997;272(26):16548-54.
1996: Patricia C Babbitt; Miriam S Hasson; J E Wedekind; DR Palmer; William Barrett; George H Reed; Ivan Rayment; Dagmar Ringe; G L Kenyon; John Alan Gerlt
The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids.
Biochemistry 1996;35(51):16489-501.
1996: D L McCarthy; S Navarrete; W S Willett; Patricia C Babbitt; Shelley D Copley
Exploration of the relationship between tetrachlorohydroquinone dehalogenase and the glutathione S-transferase superfamily.
Biochemistry 1996;35(46):14634-42.
1996: Troy D Wood; L H Chen; C B White; Patricia C Babbitt; G L Kenyon; Fred W McLafferty
Sequence verification of human creatine kinase (43 kDa) isozymes by high-resolution tandem mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):12051.
1995: Troy D Wood; L H Chen; C B White; Patricia C Babbitt; G L Kenyon; Fred W McLafferty
Sequence verification of human creatine kinase (43 kDa) isozymes by high-resolution tandem mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11451-5.
1995: C B White; Q Chen; G L Kenyon; Patricia C Babbitt
A novel activity of OmpT. Proteolysis under extreme denaturing conditions.
The Journal of biological chemistry 1995;270(22):12990-4.
1995: Patricia C Babbitt; G T Mrachko; Miriam S Hasson; G W Huisman; Roberto Kolter; Dagmar Ringe; Gregory A Petsko; G L Kenyon; John Alan Gerlt
A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids.
Science (New York, N.Y.) 1995;267(5201):1159-61.
1994: Debra Dunaway-Mariano; Patricia C Babbitt
On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.
Biodegradation 1994;5(3-4):259-76.
1993: Bharati Mitra; John Alan Gerlt; Patricia C Babbitt; C W Koo; G L Kenyon; D Joseph; Gregory A Petsko
A novel structural basis for membrane association of a protein: construction of a chimeric soluble mutant of (S)-mandelate dehydrogenase from Pseudomonas putida.
Biochemistry 1993;32(48):12959-67.
1992: S E Williams; E M Woolridge; S C Ransom; J A Landro; Patricia C Babbitt; John W Kozarich
3-Carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida is homologous to the class II fumarase family: a new reaction in the evolution of a mechanistic motif.
Biochemistry 1992;31(40):9768-76.
1992: K C White; Patricia C Babbitt; D D Buechter; G L Kenyon
The principal islet of the Coho salmon (Oncorhyncus kisutch) contains the BB isoenzyme of creatine kinase.
Journal of protein chemistry 1992;11(5):489-94.
1992: Patricia C Babbitt; G L Kenyon; B M Martin; H Charest; M Slyvestre; J D Scholten; K H Chang; P H Liang; Debra Dunaway-Mariano
Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases.
Biochemistry 1992;31(24):5594-604.
1991: J D Scholten; K H Chang; Patricia C Babbitt; H Charest; Michel Sylvestre; Debra Dunaway-Mariano
Novel enzymic hydrolytic dehalogenation of a chlorinated aromatic.
Science (New York, N.Y.) 1991;253(5016):182-5.
1991: L H Chen; Patricia C Babbitt; J R Vásquez; Brian L West; G L Kenyon
Cloning and expression of functional rabbit muscle creatine kinase in Escherichia coli. Addressing the problem of microheterogeneity.
The Journal of biological chemistry 1991;266(18):12053-7.
1990: D J Pocalyko; L J Carroll; B M Martin; Patricia C Babbitt; Debra Dunaway-Mariano
Analysis of sequence homologies in plant and bacterial pyruvate phosphate dikinase, enzyme I of the bacterial phosphoenolpyruvate: sugar phosphotransferase system and other PEP-utilizing enzymes. Identification of potential catalytic and regulatory motifs.
Biochemistry 1990;29(48):10757-65.
1990: A Y Tsou; S C Ransom; John Alan Gerlt; D D Buechter; Patricia C Babbitt; G L Kenyon
Mandelate pathway of Pseudomonas putida: sequence relationships involving mandelate racemase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase and expression of benzoylformate decarboxylase in Escherichia coli.
Biochemistry 1990;29(42):9856-62.
1990: Patricia C Babbitt; Brian L West; D D Buechter; Irwin D Kuntz; G L Kenyon
Removal of a proteolytic activity associated with aggregates formed from expression of creatine kinase in Escherichia coli leads to improved recovery of active enzyme.
Bio/technology (Nature Publishing Company) 1990;8(10):945-9.
1984: Brian L West; Patricia C Babbitt; B Mendez; J D Baxter
Creatine kinase protein sequence encoded by a cDNA made from Torpedo californica electric organ mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(22):7007-11.