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Aldo Jongejan

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Atilla Akdemir; Daniel Bertrand; Sonia Bertrand; Chris de Graaf; Aldo Jongejan; Rob Leurs; Prakash Rucktooa; Titia K Sixma; August B Smit; Rene van Elk; Iwan J P De Esch
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.
Maikel Wijtmans; Chris de Graaf; Gerdien de Kloe; Enade P Istyastono; Judith Smit; Herman Lim; Ratchanok Boonnak; Saskia Nijmeijer; Rogier A Smits; Aldo Jongejan; Obbe Zuiderveld; Iwan J P De Esch; Rob Leurs
Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity.
Kamonchanok Sansuk; Xavier Deupi; Ivan Rodriguez Torrecillas; Aldo Jongejan; Saskia Nijmeijer; Remko A Bakker; Leonardo Pardo; Rob Leurs
A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation.

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All Publications

2011: Atilla Akdemir; Daniel Bertrand; Sonia Bertrand; Chris de Graaf; Aldo Jongejan; Rob Leurs; Prakash Rucktooa; Titia K Sixma; August B Smit; Rene van Elk; Iwan J P De Esch
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.
Bioorganic & medicinal chemistry 2011;19(20):6107-19.
2011: Maikel Wijtmans; Chris de Graaf; Gerdien de Kloe; Enade P Istyastono; Judith Smit; Herman Lim; Ratchanok Boonnak; Saskia Nijmeijer; Rogier A Smits; Aldo Jongejan; Obbe Zuiderveld; Iwan J P De Esch; Rob Leurs
Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity.
Journal of medicinal chemistry 2011;54(6):1693-703.
2011: Kamonchanok Sansuk; Xavier Deupi; Ivan Rodriguez Torrecillas; Aldo Jongejan; Saskia Nijmeijer; Remko A Bakker; Leonardo Pardo; Rob Leurs
A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation.
Molecular pharmacology 2011;79(2):262-9.
2010: Rogier A Smits; Maristella Adami; Enade P Istyastono; Obbe P Zuiderveld; Cindy M E van Dam; Frans J J de Kanter; Aldo Jongejan; Gabriella Coruzzi; Rob Leurs; Iwan J P De Esch
Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists.
Journal of medicinal chemistry 2010;53(6):2390-400.
2009: Herman D Lim; Enade P Istyastono; Andrea van de Stolpe; Giuseppe Romeo; Silvia Gobbi; Marjo Schepers; Roger Lahaye; Wiro M P B Menge; Obbe P Zuiderveld; Aldo Jongejan; Rogier A Smits; Remko A Bakker; Eric E J Haaksma; Rob Leurs; Iwan J P De Esch
Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.
Bioorganic & medicinal chemistry 2009;17(11):3987-94.
2008: Herman D Lim; Aldo Jongejan; Remko A Bakker; Eric Haaksma; Iwan J P De Esch; Rob Leurs
Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors.
The Journal of pharmacology and experimental therapeutics 2008;327(1):88-96.
2008: Remko A Bakker; Aldo Jongejan; Kamonchanok Sansuk; Uli Hacksell; Henk Timmerman; Mark R Brann; David M Weiner; Leonardo Pardo; Rob Leurs
Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors.
Molecular pharmacology 2008;73(1):94-103.
2007: Niels Hulsman; Jan Paul Medema; Carina Bos; Aldo Jongejan; Rob Leurs; Martine J Smit; Iwan J P De Esch; Dick Richel; Maikel Wijtmans
Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin.
Journal of medicinal chemistry 2007;50(10):2424-31.
2007: Martine J Smit; Henry Vischer; Remko A Bakker; Aldo Jongejan; Henk Timmerman; Leonardo Pardo; Rob Leurs
Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.
Annual review of pharmacology and toxicology 2007;47():53-87.
2006: Dennis Verzijl; Leonardo Pardo; Marie Van Dijk; Yvonne K Gruijthuijsen; Aldo Jongejan; Henk Timmerman; John Nicholas; Mario Schwarz; Philip M Murphy; Rob Leurs; Martine J Smit
Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding.
The Journal of biological chemistry 2006;281(46):35327-35.
2006: Yu Zhou; Chris Oostenbrink; Aldo Jongejan; Wilfred F van Gunsteren; Wilfred R Hagen; Simon W De Leeuw; Jaap A Jongejan
Computational study of ground-state chiral induction in small peptides: comparison of the relative stability of selected amino acid dimers and oligomers in homochiral and heterochiral combinations.
Journal of computational chemistry 2006;27(7):857-67.
2006: Chris de Graaf; Chris Oostenbrink; Peter H J Keizers; Tushar van der Wijst; Aldo Jongejan; Nico P E Vermeulen
Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking.
Journal of medicinal chemistry 2006;49(8):2417-30.
2005: Martijn Bruysters; Aldo Jongejan; Atilla Akdemir; Remko A Bakker; Rob Leurs
A G(q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL).
The Journal of biological chemistry 2005;280(41):34741-6.
2005: Iwan J P De Esch; Robin Thurmond; Aldo Jongejan; Rob Leurs
The histamine H4 receptor as a new therapeutic target for inflammation.
Trends in pharmacological sciences 2005;26(9):462-9.
2005: Aldo Jongejan; Martijn Bruysters; Juan A Ballesteros; Eric Haaksma; Remko A Bakker; Leonardo Pardo; Rob Leurs
Linking agonist binding to histamine H1 receptor activation.
Nature chemical biology 2005;1(2):98-103.
2005: Aldo Jongejan; Rob Leurs
Delineation of receptor-ligand interactions at the human histamine H1 receptor by a combined approach of site-directed mutagenesis and computational techniques - or - how to bind the H1 receptor.
Archiv der Pharmazie 2005;338(5-6):248-59.
2005: Martijn Bruysters; Aldo Jongejan; Michel Gillard; Frank van de Manakker; Remko A Bakker; Pierre Chatelain; Rob Leurs
Pharmacological differences between human and guinea pig histamine H1 receptors: Asn84 (2.61) as key residue within an additional binding pocket in the H1 receptor.
Molecular pharmacology 2005;67(4):1045-52.
2005: Aldo Jongejan; Chris de Graaf; Nico P E Vermeulen; Rob Leurs; Iwan J P De Esch
The role and application of in silico docking in chemical genomics research.
Methods in molecular biology (Clifton, N.J.) 2005;310():63-91.
2004: Marola M H van Lipzig; Antonius Marinus ter Laak; Aldo Jongejan; Nico P E Vermeulen; Mirjam M C Wamelink; Daan Geerke; John Meerman
Prediction of ligand binding affinity and orientation of xenoestrogens to the estrogen receptor by molecular dynamics simulations and the linear interaction energy method.
Journal of medicinal chemistry 2004;47(4):1018-30.
2003: Aldo Jongejan; Jaap A Jongejan; Wilfred R Hagen
Deuterium isotope effect on enantioselectivity in the Comamonas testosteroni quinohemoprotein alcohol dehydrogenase-catalyzed kinetic resolution of rac-2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, solketal.
Biochimica et biophysica acta 2003;1647(1-2):297-302.
2003: Paola Casarosa; Wiro M P B Menge; Rosalba Minisini; Claas Otto; Jane van Heteren; Aldo Jongejan; Henk Timmerman; Barbara Moepps; Frank Kirchhoff; Thomas Mertens; Martine J Smit; Rob Leurs
Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor.
The Journal of biological chemistry 2003;278(7):5172-8.
1998: Aldo Jongejan; Jaap A Jongejan; Johannis A Duine
Homology model of the quinohaemoprotein alcohol dehydrogenase from Comamonas testosteroni.
Protein engineering 1998;11(3):185-98.