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Hirofumi Jono

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Kensei Komatsu; Ji-Yun Lee; Masanori Miyata; Haidong Xu; Chen Yan; Jae Hyang Lim; Hirofumi Jono; Hirofumi Kai; Tomoaki Koga; Jian-Dong Li
Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD.
Jae Hyang Lim; Takashi Matsuno; Masanori Miyata; Soo Hyun Park; Huahao Shen; Binghe Wang; Chang-Hoon Woo; Haodong Xu; Haidong Xu; Xiangbin Xu; Chen Yan; Wenhong Zhang; Patricia Bourne; Lin Feng Chen; Yoo Duk Choi; Xin-Hua Feng; Kyung-Sun Heo; Yuxian Huang; Hirofumi Jono; Yu-Il Kim; Tomoaki Koga; Kensei Komatsu; Jiyun Lee; Jian-Dong Li
CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt.
Hirofumi Jono; Jae Hyang Lim; Haidong Xu; Jian-Dong Li
PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1.

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All Publications

2013: Kensei Komatsu; Ji-Yun Lee; Masanori Miyata; Haidong Xu; Chen Yan; Jae Hyang Lim; Hirofumi Jono; Hirofumi Kai; Tomoaki Koga; Jian-Dong Li
Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD.
Nature communications 2013;4():1684.
2012: Jae Hyang Lim; Takashi Matsuno; Masanori Miyata; Soo Hyun Park; Huahao Shen; Binghe Wang; Chang-Hoon Woo; Haodong Xu; Haidong Xu; Xiangbin Xu; Chen Yan; Wenhong Zhang; Patricia Bourne; Lin Feng Chen; Yoo Duk Choi; Xin-Hua Feng; Kyung-Sun Heo; Yuxian Huang; Hirofumi Jono; Yu-Il Kim; Tomoaki Koga; Kensei Komatsu; Jiyun Lee; Jian-Dong Li
CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt.
Nature communications 2012;3():771.
2012: Hirofumi Jono; Jae Hyang Lim; Haidong Xu; Jian-Dong Li
PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1.
PloS one 2012;7(1):e31049.
2010: Kye-Im Jeon; Xiangbin Xu; Toru Aizawa; Jae Hyang Lim; Hirofumi Jono; Dong-Seok Kwon; Jun-Ichi Abe; Bradford C Berk; Jian-Dong Li; Chen Yan
Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9795-800.
2008: Kensei Komatsu; Hirofumi Jono; Jae Hyang Lim; Akira Imasato; Haidong Xu; Hirofumi Kai; Chen Yan; Jian-Dong Li
Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK.
Biochemical and biophysical research communications 2008;377(3):763-8.
2007: Yuxian Huang; Fumi Mikami; Hirofumi Jono; Wenhong Zhang; Xinhua Weng; Tomoaki Koga; Haidong Xu; Chen Yan; Hirofumi Kai; Jian-Dong Li
Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF.
Biochemical and biophysical research communications 2007;359(3):691-6.
2007: Jae Hyang Lim; Brigid Stirling; Jonathan Derry; Tomoaki Koga; Hirofumi Jono; Chang-Hoon Woo; Haodong Xu; Patricia Bourne; Un-Hwan Ha; Hajime Ishinaga; Haidong Xu; Ali Andalibi; Xin-Hua Feng; Hongguang Zhu; Yuxian Huang; Wenhong Zhang; Xinhua Weng; Chen Yan; Zhinan Yin; David E Briles; Roger J Davis; Richard A Flavell; Jian-Dong Li
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.
Immunity 2007;27(2):349-60.
2007: Akihiro Sakai; Tomoaki Koga; Jae Hyang Lim; Hirofumi Jono; Kazutsune Harada; Erika Szymanski; Haidong Xu; Hirofumi Kai; Jian-Dong Li
The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression: evidence for negative regulation of host anti-viral response by CYLD.
The FEBS journal 2007;274(14):3655-68.
2007: Hajime Ishinaga; Hirofumi Jono; Jae Hyang Lim; Soo-Mi Kweon; Haidong Xu; Un-Hwan Ha; Haodong Xu; Tomoaki Koga; Chen Yan; Xin-Hua Feng; Lin Feng Chen; Jian-Dong Li
TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation.
The EMBO journal 2007;26(4):1150-62.
2007: Un-Hwan Ha; Jae Hyang Lim; Hirofumi Jono; Tomoaki Koga; Amit Srivastava; Richard Malley; Gilles Pagès; Jacques Pouysségur; Jian-Dong Li
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1736-47.
2007: Jae Hyang Lim; Hirofumi Jono; Tomoaki Koga; Chang-Hoon Woo; Hajime Ishinaga; Patricia Bourne; Haidong Xu; Un-Hwan Ha; Haodong Xu; Jian-Dong Li
Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice.
PloS one 2007;2(10):e1032.
2006: Soo-Mi Kweon; Beinan Wang; Davida Rixter; Jae Hyang Lim; Tomoaki Koga; Hajime Ishinaga; Lin Feng Chen; Hirofumi Jono; Haidong Xu; Jian-Dong Li
Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK.
Biochemical and biophysical research communications 2006;351(2):368-75.
2006: Fumi Mikami; Jae Hyang Lim; Hajime Ishinaga; Un-Hwan Ha; He Gu; Tomoaki Koga; Hirofumi Jono; Hirofumi Kai; Jian-Dong Li
The transforming growth factor-beta-Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual mechanism involving functional cooperation with NF-kappaB and MAPK phosphatase 1-dependent negative cross-talk with p38 MAPK.
The Journal of biological chemistry 2006;281(31):22397-408.
2005: Hiroki Yoshida; Hirofumi Jono; Hirofumi Kai; Jian-Dong Li
The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7.
The Journal of biological chemistry 2005;280(49):41111-21.
2005: Fumi Mikami; He Gu; Hirofumi Jono; Ali Andalibi; Hirofumi Kai; Jian-Dong Li
Epidermal growth factor receptor acts as a negative regulator for bacterium nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via an Src-dependent p38 mitogen-activated protein kinase signaling pathway.
The Journal of biological chemistry 2005;280(43):36185-94.
2004: Ran Chen; Jae Hyang Lim; Hirofumi Jono; Xin-Xing Gu; Young S Kim; Carol B Basbaum; Timothy F Murphy; Jian-Dong Li
Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways.
Biochemical and biophysical research communications 2004;324(3):1087-94.
2004: Hirofumi Jono; Jae Hyang Lim; Lin Feng Chen; Haidong Xu; Eirini Trompouki; Zhixing K Pan; George Mosialos; Jian-Dong Li
NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway.
The Journal of biological chemistry 2004;279(35):36171-4.
2004: Takahiro Watanabe; Hirofumi Jono; Jiahuai Han; David J Lim; Jian-Dong Li
Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3563-8.
2003: Hirofumi Jono; Haidong Xu; Hirofumi Kai; David J Lim; Young S Kim; Xin-Hua Feng; Jian-Dong Li
Transforming growth factor-beta-Smad signaling pathway negatively regulates nontypeable Haemophilus influenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK.
The Journal of biological chemistry 2003;278(30):27811-9.
2002: Hirofumi Jono; Tsuyoshi Shuto; Haidong Xu; Hirofumi Kai; David J Lim; James R Gum; Young S Kim; Shoji Yamaoka; Xin-Hua Feng; Jian-Dong Li
Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription.
The Journal of biological chemistry 2002;277(47):45547-57.
2002: Tsuyoshi Shuto; Akira Imasato; Hirofumi Jono; Akihiro Sakai; Haidong Xu; Takahiro Watanabe; Davida D Rixter; Hirofumi Kai; Ali Andalibi; Fred H Linthicum; Yue-Ling Guan; Jiahuai Han; Andrew C B Cato; David J Lim; Shizuo Akira; Jian-Dong Li
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase.
The Journal of biological chemistry 2002;277(19):17263-70.