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Frank Jordan

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Ildiko M Kovach; Frank Jordan; Lazaros Kakalis; Daoning Zhang
Proton bridging in the interactions of thrombin with hirudin and its mimics.
Anand Balakrishnan; Sumit Chakraborty; Lazaros Kakalis; Natalia Nemeria; Frank Jordan
Determination of pre-steady-state rate constants on the Escherichia coli pyruvate dehydrogenase complex reveals that loop movement controls the rate-limiting step.
Hetalben Patel; Natalia Nemeria; Leighanne A Brammer; Caren L Freel Meyers; Frank Jordan
Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate.

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All Publications

2013: Ildiko M Kovach; Frank Jordan; Lazaros Kakalis; Daoning Zhang
Proton bridging in the interactions of thrombin with hirudin and its mimics.
Biochemistry 2013;52(14):2472-81.
2012: Anand Balakrishnan; Sumit Chakraborty; Lazaros Kakalis; Natalia Nemeria; Frank Jordan
Determination of pre-steady-state rate constants on the Escherichia coli pyruvate dehydrogenase complex reveals that loop movement controls the rate-limiting step.
Journal of the American Chemical Society 2012;134(45):18644-55.
2012: Hetalben Patel; Natalia Nemeria; Leighanne A Brammer; Caren L Freel Meyers; Frank Jordan
Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate.
Journal of the American Chemical Society 2012;134(44):18374-9.
2012: Jaeyoung Song; Frank Jordan
Interchain acetyl transfer in the E2 component of bacterial pyruvate dehydrogenase suggests a model with different roles for each chain in a trimer of the homooligomeric component.
Biochemistry 2012;51(13):2795-803.
2010: Natalia Nemeria; Palaniappa Arjunan; Krishnamoorthy Chandrasekhar; Madouna Mossad; Kai Tittmann; William Furey; Frank Jordan
Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms.
The Journal of biological chemistry 2010;285(15):11197-209.
2010: Jaeyoung Song; Yun-Hee Park; Natalia Nemeria; Sachin Kale; Lazaros Kakalis; Frank Jordan
Nuclear magnetic resonance evidence for the role of the flexible regions of the E1 component of the pyruvate dehydrogenase complex from gram-negative bacteria.
The Journal of biological chemistry 2010;285(7):4680-94.
2009: Sachin Kale; Frank Jordan
Conformational ensemble modulates cooperativity in the rate-determining catalytic step in the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex.
The Journal of biological chemistry 2009;284(48):33122-9.
2009: Natalia Nemeria; Sumit Chakraborty; Anand Balakrishnan; Frank Jordan
Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps.
The FEBS journal 2009;276(9):2432-46.
2009: Gabriel S Brandt; Malea Kneen; Sumit Chakraborty; Ahmet T Baykal; Natalia Nemeria; Alejandra Yep; David I Ruby; Gregory A Petsko; George L Kenyon; Michael McLeish; Frank Jordan; Dagmar Ringe
Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor.
Biochemistry 2009;48(15):3247-57.
2009: Sumit Chakraborty; Natalia Nemeria; Anand Balakrishnan; Gabriel S Brandt; Malea Kneen; Alejandra Yep; Michael McLeish; George L Kenyon; Gregory A Petsko; Dagmar Ringe; Frank Jordan
Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase.
Biochemistry 2009;48(5):981-94.
2008: Gabriel S Brandt; Natalia Nemeria; Sumit Chakraborty; Michael McLeish; Alejandra Yep; George L Kenyon; Gregory A Petsko; Frank Jordan; Dagmar Ringe
Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester.
Biochemistry 2008;47(29):7734-43.
2008: Sumit Chakraborty; Natalia Nemeria; Alejandra Yep; Michael McLeish; George L Kenyon; Frank Jordan
Mechanism of benzaldehyde lyase studied via thiamin diphosphate-bound intermediates and kinetic isotope effects.
Biochemistry 2008;47(12):3800-9.
2008: Sachin Kale; Gözde Ulas; Jaeyoung Song; Gary W Brudvig; William Furey; Frank Jordan
Efficient coupling of catalysis and dynamics in the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1158-63.
2007: Sachin Kale; Palaniappa Arjunan; William Furey; Frank Jordan
A dynamic loop at the active center of the Escherichia coli pyruvate dehydrogenase complex E1 component modulates substrate utilization and chemical communication with the E2 component.
The Journal of biological chemistry 2007;282(38):28106-16.
2007: Natalia Nemeria; Lioubov G Korotchkina; Michael McLeish; George L Kenyon; Mulchand S Patel; Frank Jordan
Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states.
Biochemistry 2007;46(37):10739-44.
2007: Reinhard Schweitzer-Stenner; Thomas Measey; Lazaros Kakalis; Frank Jordan; Silvia Pizzanelli; Claudia Forte; Kai Griebenow
Conformations of alanine-based peptides in water probed by FTIR, Raman, vibrational circular dichroism, electronic circular dichroism, and NMR spectroscopy.
Biochemistry 2007;46(6):1587-96.
2007: Natalia Nemeria; Sumit Chakraborty; Ahmet Baykal; Lioubov G Korotchkina; Mulchand S Patel; Frank Jordan
The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):78-82.
2006: Ahmet Baykal; Sumit Chakraborty; Afua Dodoo; Frank Jordan
Synthesis with good enantiomeric excess of both enantiomers of alpha-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases.
Bioorganic chemistry 2006;34(6):380-93.
2006: Natalia Nemeria; Lioubov G Korotchkina; Sumit Chakraborty; Mulchand S Patel; Frank Jordan
Acetylphosphinate is the most potent mechanism-based substrate-like inhibitor of both the human and Escherichia coli pyruvate dehydrogenase components of the pyruvate dehydrogenase complex.
Bioorganic chemistry 2006;34(6):362-79.
2006: Ebenezer Joseph; Wen Wei; Kai Tittmann; Frank Jordan
Function of a conserved loop of the beta-domain, not involved in thiamin diphosphate binding, in catalysis and substrate activation in yeast pyruvate decarboxylase.
Biochemistry 2006;45(45):13517-27.
2006: Krishnamoorthy Chandrasekhar; Palaniappa Arjunan; Martin Sax; Natalia Nemeria; Frank Jordan; William Furey
Active-site changes in the pyruvate dehydrogenase multienzyme complex E1 apoenzyme component from Escherichia coli observed at 2.32 A resolution.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 11):1382-6.
2006: Ahmet Baykal; Lazaros Kakalis; Frank Jordan
Electronic and nuclear magnetic resonance spectroscopic features of the 1',4'-iminopyrimidine tautomeric form of thiamin diphosphate, a novel intermediate on enzymes requiring this coenzyme.
Biochemistry 2006;45(24):7522-8.
2006: Palaniappa Arjunan; Martin Sax; Andrew Brunskill; Krishnamoorthy Chandrasekhar; Natalia Nemeria; Sheng Zhang; Frank Jordan; William Furey
A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct.
The Journal of biological chemistry 2006;281(22):15296-303.
2005: Frank Jordan; Natalia Nemeria; Eduard A Sergienko
Multiple modes of active center communication in thiamin diphosphate-dependent enzymes.
Accounts of chemical research 2005;38(9):755-63.
2005: Natalia Nemeria; Kai Tittmann; Ebenezer Joseph; Leon Zhou; Michelle B Vazquez-Coll; Palaniappa Arjunan; Gerhard Hübner; William Furey; Frank Jordan
Glutamate 636 of the Escherichia coli pyruvate dehydrogenase-E1 participates in active center communication and behaves as an engineered acetolactate synthase with unusual stereoselectivity.
The Journal of biological chemistry 2005;280(22):21473-82.
2005: Frank Jordan; Natalia Nemeria
Experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations.
Bioorganic chemistry 2005;33(3):190-215.
2005: Sheng Zhang; Leon Zhou; Natalia Nemeria; Yan Yan; Zhen Zhang; Yu Zou; Frank Jordan
Evidence for dramatic acceleration of a C-H bond ionization rate in thiamin diphosphate enzymes by the protein environment.
Biochemistry 2005;44(7):2237-43.
2004: Sheng Zhang; Min Liu; Yan Yan; Zhen Zhang; Frank Jordan
C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models.
The Journal of biological chemistry 2004;279(52):54312-8.
2004: Yun-Hee Park; Wen Wei; Leon Zhou; Natalia Nemeria; Frank Jordan
Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit.
Biochemistry 2004;43(44):14037-46.
2004: Frank Jordan
Biochemistry. How active sites communicate in thiamine enzymes.
Science (New York, N.Y.) 2004;306(5697):818-20.
2004: Natalia Nemeria; Ahmet Baykal; Ebenezer Joseph; Sheng Zhang; Yan Yan; William Furey; Frank Jordan
Tetrahedral intermediates in thiamin diphosphate-dependent decarboxylations exist as a 1',4'-imino tautomeric form of the coenzyme, unlike the michaelis complex or the free coenzyme.
Biochemistry 2004;43(21):6565-75.
2004: Palaniappa Arjunan; Krishnamoorthy Chandrasekhar; Martin Sax; Andrew Brunskill; Natalia Nemeria; Frank Jordan; William Furey
Structural determinants of enzyme binding affinity: the E1 component of pyruvate dehydrogenase from Escherichia coli in complex with the inhibitor thiamin thiazolone diphosphate.
Biochemistry 2004;43(9):2405-11.
2003: Frank Jordan; Natalia Nemeria; Sheng Zhang; Yan Yan; Palaniappa Arjunan; William Furey
Dual catalytic apparatus of the thiamin diphosphate coenzyme: acid-base via the 1',4'-iminopyrimidine tautomer along with its electrophilic role.
Journal of the American Chemical Society 2003;125(42):12732-8.
2003: Kai Tittmann; Ralph Golbik; Kathrin Uhlemann; Ludmila Khailova; Gunter Schneider; Mulchand Patel; Frank Jordan; David M Chipman; Ronald Duggleby; Gerhard Hübner
NMR analysis of covalent intermediates in thiamin diphosphate enzymes.
Biochemistry 2003;42(26):7885-91.
2003: Frank Jordan
Current mechanistic understanding of thiamin diphosphate-dependent enzymatic reactions.
Natural product reports 2003;20(2):184-201.
2003: Wen Wei; Hong Li; Natalia Nemeria; Frank Jordan
Expression and purification of the dihydrolipoamide acetyltransferase and dihydrolipoamide dehydrogenase subunits of the Escherichia coli pyruvate dehydrogenase multienzyme complex: a mass spectrometric assay for reductive acetylation of dihydrolipoamide acetyltransferase.
Protein expression and purification 2003;28(1):140-50.
2003: Elena S Polovnikova; Michael McLeish; Eduard A Sergienko; John T Burgner; Natalie L Anderson; Aloke Kumar Bera; Frank Jordan; George L Kenyon; Miriam S Hasson
Structural and kinetic analysis of catalysis by a thiamin diphosphate-dependent enzyme, benzoylformate decarboxylase.
Biochemistry 2003;42(7):1820-30.
2002: Natalia Nemeria; Palaniappa Arjunan; Andrew Brunskill; Farzad Sheibani; Wen Wei; Yan Yan; Sheng Zhang; Frank Jordan; William Furey
Histidine 407, a phantom residue in the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex, activates reductive acetylation of lipoamide on the E2 subunit. An explanation for conservation of active sites between the E1 subunit and transketolase.
Biochemistry 2002;41(52):15459-67.
2002: Frank Jordan; Zhen Zhang; Eduard A Sergienko
Spectroscopic evidence for participation of the 1',4'-imino tautomer of thiamin diphosphate in catalysis by yeast pyruvate decarboxylase.
Bioorganic chemistry 2002;30(3):188-98.
2002: Eduard A Sergienko; Frank Jordan
Yeast pyruvate decarboxylase tetramers can dissociate into dimers along two interfaces. Hybrids of low-activity D28A (or D28N) and E477Q variants, with substitution of adjacent active center acidic groups from different subunits, display restored activity.
Biochemistry 2002;41(19):6164-9.
2002: Palaniappa Arjunan; Natalia Nemeria; Andrew Brunskill; Krishnamoorthy Chandrasekhar; Martin Sax; Yan Yan; Frank Jordan; John R Guest; William Furey
Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution.
Biochemistry 2002;41(16):5213-21.
2002: Ara Kahyaoglu; Frank Jordan
Direct proton magnetic resonance determination of the pKa of the active center histidine in thiolsubtilisin.
Protein science : a publication of the Protein Society 2002;11(4):965-73.
2002: Eduard A Sergienko; Frank Jordan
New model for activation of yeast pyruvate decarboxylase by substrate consistent with the alternating sites mechanism: demonstration of the existence of two active forms of the enzyme.
Biochemistry 2002;41(12):3952-67.
2002: Wen Wei; Min Liu; Frank Jordan
Solvent kinetic isotope effects monitor changes in hydrogen bonding at the active center of yeast pyruvate decarboxylase concomitant with substrate activation: the substituent at position 221 can control the state of activation.
Biochemistry 2002;41(2):451-61.
2001: Natalia Nemeria; Yan Yan; Z Zhang; A M Brown; Palaniappa Arjunan; William Furey; John R Guest; Frank Jordan
Inhibition of the Escherichia coli pyruvate dehydrogenase complex E1 subunit and its tyrosine 177 variants by thiamin 2-thiazolone and thiamin 2-thiothiazolone diphosphates. Evidence for reversible tight-binding inhibition.
The Journal of biological chemistry 2001;276(49):45969-78.
2001: Eduard A Sergienko; Frank Jordan
Catalytic acid-base groups in yeast pyruvate decarboxylase. 3. A steady-state kinetic model consistent with the behavior of both wild-type and variant enzymes at all relevant pH values.
Biochemistry 2001;40(25):7382-403.
2001: Eduard A Sergienko; Frank Jordan
Catalytic acid-base groups in yeast pyruvate decarboxylase. 2. Insights into the specific roles of D28 and E477 from the rates and stereospecificity of formation of carboligase side products.
Biochemistry 2001;40(25):7369-81.
2001: M Liu; Eduard A Sergienko; F Guo; J Wang; Kai Tittmann; Gerhard Hübner; William Furey; Frank Jordan
Catalytic acid-base groups in yeast pyruvate decarboxylase. 1. Site-directed mutagenesis and steady-state kinetic studies on the enzyme with the D28A, H114F, H115F, and E477Q substitutions.
Biochemistry 2001;40(25):7355-68.
2001: J Wang; Ralph Golbik; B Seliger; Michael Spinka; Kai Tittmann; Gerhard Hübner; Frank Jordan
Consequences of a modified putative substrate-activation site on catalysis by yeast pyruvate decarboxylase.
Biochemistry 2001;40(6):1755-63.
2000: Eduard A Sergienko; J Wang; Lena S Polovnikova; Miriam S Hasson; Michael McLeish; George L Kenyon; Frank Jordan
Spectroscopic detection of transient thiamin diphosphate-bound intermediates on benzoylformate decarboxylase.
Biochemistry 2000;39(45):13862-9.
1999: Frank Jordan
Interplay of organic and biological chemistry in understanding coenzyme mechanisms: example of thiamin diphosphate-dependent decarboxylations of 2-oxo acids.
FEBS letters 1999;457(3):298-301.
1999: H Li; Frank Jordan
Effects of substitution of tryptophan 412 in the substrate activation pathway of yeast pyruvate decarboxylase.
Biochemistry 1999;38(31):10004-12.
1999: H Li; William Furey; Frank Jordan
Role of glutamate 91 in information transfer during substrate activation of yeast pyruvate decarboxylase.
Biochemistry 1999;38(31):9992-10003.
1999: Frank Jordan; H Li; A Brown
Remarkable stabilization of zwitterionic intermediates may account for a billion-fold rate acceleration by thiamin diphosphate-dependent decarboxylases.
Biochemistry 1999;38(20):6369-73.
1998: F Guo; D Zhang; Ara Kahyaoglu; R S Farid; Frank Jordan
Is a hydrophobic amino acid required to maintain the reactive V conformation of thiamin at the active center of thiamin diphosphate-requiring enzymes? Experimental and computational studies of isoleucine 415 of yeast pyruvate decarboxylase.
Biochemistry 1998;37(38):13379-91.
1998: Frank Jordan; Natalia Nemeria; F Guo; I Baburina; Y Gao; Ara Kahyaoglu; H Li; J Wang; Jihyun Lee; John R Guest; William Furey
Regulation of thiamin diphosphate-dependent 2-oxo acid decarboxylases by substrate and thiamin diphosphate.Mg(II) - evidence for tertiary and quaternary interactions.
Biochimica et biophysica acta 1998;1385(2):287-306.
1998: William Furey; Palaniappa Arjunan; L Chen; Martin Sax; F Guo; Frank Jordan
Structure-function relationships and flexible tetramer assembly in pyruvate decarboxylase revealed by analysis of crystal structures.
Biochimica et biophysica acta 1998;1385(2):253-70.
1998: K Pan; Frank Jordan
D,L-S-methyllipoic acid methyl ester, a kinetically viable model for S-protonated lipoic acid as the oxidizing agent in reductive acyl transfers catalyzed by the 2-oxoacid dehydrogenase multienzyme complexes.
Biochemistry 1998;37(5):1357-64.
1998: I Baburina; G Dikdan; F Guo; Guillermo I Tous; B Root; Frank Jordan
Reactivity at the substrate activation site of yeast pyruvate decarboxylase: inhibition by distortion of domain interactions.
Biochemistry 1998;37(5):1245-55.
1998: I Baburina; H Li; B Bennion; William Furey; Frank Jordan
Interdomain information transfer during substrate activation of yeast pyruvate decarboxylase: the interaction between cysteine 221 and histidine 92.
Biochemistry 1998;37(5):1235-44.
1998: Natalia Nemeria; A Volkov; A Brown; Jihyun Lee; L Zipper; John R Guest; Frank Jordan
Systematic study of the six cysteines of the E1 subunit of the pyruvate dehydrogenase multienzyme complex from Escherichia coli: none is essential for activity.
Biochemistry 1998;37(3):911-22.
1997: Ara Kahyaoglu; K Haghjoo; F Guo; Frank Jordan; C Kettner; F Felföldi; László Polgár
Low barrier hydrogen bond is absent in the catalytic triads in the ground state but Is present in a transition-state complex in the prolyl oligopeptidase family of serine proteases.
The Journal of biological chemistry 1997;272(41):25547-54.
1997: A Brown; Natalia Nemeria; Jihyun Lee; D Zhang; W B Jordan; R S Machado; John R Guest; Frank Jordan
2-Oxo-3-alkynoic acids, universal mechanism-based inactivators of thiamin diphosphate-dependent decarboxylases: synthesis and evidence for potent inactivation of the pyruvate dehydrogenase multienzyme complex.
Biochemistry 1997;36(26):8071-81.
1997: Ara Kahyaoglu; K Haghjoo; F Kraicsovits; Frank Jordan; L Polgar
Benzyloxycarbonylprolylprolinal, a transition-state analogue for prolyl oligopeptidase, forms a tetrahedral adduct with catalytic serine, not a reactive cysteine.
The Biochemical journal 1997;322 ( Pt 3)():839-43.
1996: J Yi; Natalia Nemeria; A McNally; Frank Jordan; R S Machado; John R Guest
Effect of substitutions in the thiamin diphosphate-magnesium fold on the activation of the pyruvate dehydrogenase complex from Escherichia coli by cofactors and substrate.
The Journal of biological chemistry 1996;271(52):33192-200.
1996: K Haghjoo; P W Cash; R S Farid; B R Komisaruk; Frank Jordan; S S Pochapsky
Solution structure of vasoactive intestinal polypeptide (11-28)-NH2, a fragment with analgesic properties.
Peptide research 1996;9(6):327-31.
1996: A Volkov; Frank Jordan
Evidence for intramolecular processing of prosubtilisin sequestered on a solid support.
Journal of molecular biology 1996;262(5):595-9.
1996: I Baburina; David J Moore; A Volkov; Ara Kahyaoglu; Frank Jordan; R Mendelsohn
Three of four cysteines, including that responsible for substrate activation, are ionized at pH 6.0 in yeast pyruvate decarboxylase: evidence from Fourier transform infrared and isoelectric focusing studies.
Biochemistry 1996;35(32):10249-55.
1996: P Arjunan; T Umland; F Dyda; Subramanyam Swaminathan; William Furey; M Sax; B Farrenkopf; Y Gao; D Zhang; Frank Jordan
Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution.
Journal of molecular biology 1996;256(3):590-600.
1996: Z Hu; K Haghjoo; Frank Jordan
Further evidence for the structure of the subtilisin propeptide and for its interactions with mature subtilisin.
The Journal of biological chemistry 1996;271(7):3375-84.
1995: Y Li; Z Hu; Frank Jordan; Masayori Inouye
Functional analysis of the propeptide of subtilisin E as an intramolecular chaperone for protein folding. Refolding and inhibitory abilities of propeptide mutants.
The Journal of biological chemistry 1995;270(42):25127-32.
1994: I Baburina; Y Gao; Z Hu; Frank Jordan; Stefan Hohmann; William Furey
Substrate activation of brewers' yeast pyruvate decarboxylase is abolished by mutation of cysteine 221 to serine.
Biochemistry 1994;33(18):5630-5.
1994: Z Hu; X Zhu; Frank Jordan; M Inouye
A covalently trapped folding intermediate of subtilisin E: spontaneous dimerization of a prosubtilisin E Ser49Cys mutant in vivo and its autoprocessing in vitro.
Biochemistry 1994;33(2):562-9.
1993: Y A Muller; Ylva Lindqvist; William Furey; Georg E Schulz; Frank Jordan; G Schneider
A thiamin diphosphate binding fold revealed by comparison of the crystal structures of transketolase, pyruvate oxidase and pyruvate decarboxylase.
Structure (London, England : 1993) 1993;1(2):95-103.
1993: F Dyda; William Furey; Subramanyam Swaminathan; M Sax; B Farrenkopf; Frank Jordan
Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-A resolution.
Biochemistry 1993;32(24):6165-70.
1993: W J Skawinski; F Adebodun; J T Cheng; Frank Jordan; R Mendelsohn
Labeling of tyrosines in proteins with [15N]tetranitromethane, a new NMR reporter for nitrotyrosines.
Biochimica et biophysica acta 1993;1162(3):297-308.
1993: X Zeng; B Farrenkopf; Stefan Hohmann; F Dyda; William Furey; Frank Jordan
Role of cysteines in the activation and inactivation of brewers' yeast pyruvate decarboxylase investigated with a PDC1-PDC6 fusion protein.
Biochemistry 1993;32(10):2704-9.
1992: A McNally; Frank Jordan
An immunochemical assay model system for the sensitive detection of pyruvate dehydrogenase complex (PDHc) and its decarboxylating subunit pyruvate dehydrogenase (E1).
Biochimica et biophysica acta 1992;1160(2):179-87.
1991: Y Ohta; H Hojo; S Aimoto; T Kobayashi; X Zhu; Frank Jordan; Masayori Inouye
Pro-peptide as an intramolecular chaperone: renaturation of denatured subtilisin E with a synthetic pro-peptide [corrected].
Molecular microbiology 1991;5(6):1507-10.
1990: F Dyda; William Furey; Subramanyam Swaminathan; M Sax; B Farrenkopf; Frank Jordan
Preliminary crystallographic data for the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from brewers' yeast.
The Journal of biological chemistry 1990;265(29):17413-5.
1990: Norma J Greenfield; C N Cherapak; F Adebodun; Frank Jordan; John Lenard
Intracellular sodium content of a wall-less strain of Neurospora crassa and effects of insulin: a 23Na-NMR study.
Biochimica et biophysica acta 1990;1025(1):15-20.
1990: Guillermo I Tous; A Bush; A Tous; Frank Jordan
O'-(epoxyalkyl)tyrosines and (epoxyalkyl)phenylalanine as irreversible inactivators of serine proteases: synthesis and inhibition mechanism.
Journal of medicinal chemistry 1990;33(6):1620-34.
1989: F Adebodun; Frank Jordan
Multinuclear magnetic resonance studies on the calcium (II) binding site in trypsin, chymotrypsin, and subtilisin.
Biochemistry 1989;28(19):7524-31.
1989: P W Cash; X Zhu; Y Ohta; J Tsao; Henry Lackland; M D Mateos-Nevado; M Inouye; Stanley Stein; Frank Jordan; Guillermo I Tous
Synthesis of the pro-peptide of subtilisin BPN'.
Peptide research 1989;2(4):292-6.
1989: F Adebodun; Frank Jordan
Multinuclear magnetic resonance studies on serine protease transition state analogues.
Journal of cellular biochemistry 1989;40(2):249-60.
1989: Norma J Greenfield; X H Wu; Frank Jordan
Proton magnetic resonance spectra of adrenodoxin: features of the aromatic region.
Biochimica et biophysica acta 1989;995(3):246-54.
1988: Norma J Greenfield; M A McKenzie; F Adebodun; Frank Jordan; John Lenard
Metabolism of D-glucose in a wall-less mutant of Neurospora crassa examined by 13C and 31P nuclear magnetic resonances: effects of insulin.
Biochemistry 1988;27(23):8526-33.
1988: S E Fawell; M A McKenzie; Norma J Greenfield; F Adebodun; Frank Jordan; John Lenard
Stimulation by mammalian insulin of glycogen metabolism in a wall-less strain of Neurospora crassa.
Endocrinology 1988;122(2):518-23.
1986: D J Kuo; G Dikdan; Frank Jordan
Resolution of brewers' yeast pyruvate decarboxylase into two isozymes.
The Journal of biological chemistry 1986;261(7):3316-9.
1986: Frank Jordan; J Adams; B Farzami; Z H Kudzin
Conjugated alpha-keto acids as mechanism-based inactivators of brewer's yeast pyruvate decarboxylase: electronic effects of substituents and detection of a long-lived intermediate.
Journal of enzyme inhibition 1986;1(2):139-49.
1985: Frank Jordan; L Polgar; Guillermo I Tous
Proton magnetic resonance studies of the states of ionization of histidines in native and modified subtilisins.
Biochemistry 1985;24(26):7711-7.
1983: D J Kuo; Frank Jordan
Direct spectroscopic observation of a brewer's yeast pyruvate decarboxylase-bound enamine intermediate produced from a suicide substrate. Evidence for nonconcerted decarboxylation.
The Journal of biological chemistry 1983;258(22):13415-7.
1983: D J Kuo; Frank Jordan
Active site directed irreversible inactivation of brewers' yeast pyruvate decarboxylase by the conjugated substrate analogue (E)-4-(4-chlorophenyl)-2-oxo-3-butenoic acid: development of a suicide substrate.
Biochemistry 1983;22(16):3735-40.
1981: Frank Jordan; László Polgár
Proton nuclear magnetic resonance evidence for the absence of a stable hydrogen bond between the active site aspartate and histidine residues of native subtilisins and for its presence in thiolsubtilisins.
Biochemistry 1981;20(22):6366-70.