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Sean Joseph

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

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Arteriosclerosis

Physiology

Gene Expression Regulation

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Publications

TOP 3
Steven J Bensinger; Michelle N Bradley; Sean B Joseph; Noam Zelcer; edith janssen; Mary Ann Hausner; Roger Shih; John S Parks; Peter A Edwards; Beth D Jamieson; Peter Tontonoz
LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Michelle N Bradley; Cynthia Hong; Mingyi Chen; Sean B Joseph; DAMIEN WILPITZ; Xuping Wang; Aldons J Lusis; Allan Collins; Willa A Hseuh; Jon L Collins; Rajendra K Tangirala; Peter Tontonoz
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.
Sean B Joseph; Michelle N Bradley; Antonio Castrillo; Kevin W Bruhn; Puiying A Mak; Liming Pei; John Hogenesch; Ryan M O'Connell; Genhong Cheng; Enrique Saez; Jeff F Miller; Peter Tontonoz
LXR-dependent gene expression is important for macrophage survival and the innate immune response.

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All Publications

2008: Steven J Bensinger; Michelle N Bradley; Sean B Joseph; Noam Zelcer; edith janssen; Mary Ann Hausner; Roger Shih; John S Parks; Peter A Edwards; Beth D Jamieson; Peter Tontonoz
LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Cell 2008;134(1):97-111.
2007: Michelle N Bradley; Cynthia Hong; Mingyi Chen; Sean B Joseph; DAMIEN WILPITZ; Xuping Wang; Aldons J Lusis; Allan Collins; Willa A Hseuh; Jon L Collins; Rajendra K Tangirala; Peter Tontonoz
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.
The Journal of clinical investigation 2007;117(8):2337-46.
2004: Sean B Joseph; Michelle N Bradley; Antonio Castrillo; Kevin W Bruhn; Puiying A Mak; Liming Pei; John Hogenesch; Ryan M O'Connell; Genhong Cheng; Enrique Saez; Jeff F Miller; Peter Tontonoz
LXR-dependent gene expression is important for macrophage survival and the innate immune response.
Cell 2004;119(2):299-309.
2004: Robert Walczak; Sean B Joseph; Bryan A Laffitte; Antonio Castrillo; Liming Pei; Peter Tontonoz
Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.
The Journal of biological chemistry 2004;279(11):9905-11.
2004: Jun Xu; Vicky Chang; Sean B Joseph; Chuck Trujillo; Sara Bassilian; Mohammed F Saad; W N Paul Lee; Irwin Kurland
Peroxisomal proliferator-activated receptor alpha deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux.
Endocrinology 2004;145(3):1087-95.
2003: Antonio Castrillo; Sean B Joseph; Sagar A Vaidya; Margaret Haberland; Alan M Fogelman; Genhong Cheng; Peter Tontonoz
Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism.
Molecular cell 2003;12(4):805-16.
2003: Bryan A Laffitte; Lily C Chao; Jing Li; Robert Walczak; Sarah Hummasti; Sean B Joseph; Antonio Castrillo; DAMIEN WILPITZ; David J Mangelsdorf; Jon L Collins; Enrique Saez; Peter Tontonoz
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5419-24.
2003: Sean B Joseph; Peter Tontonoz
LXRs: new therapeutic targets in atherosclerosis?
Current opinion in pharmacology 2003;3(2):192-7.
2003: Antonio Castrillo; Sean B Joseph; Chaitra Marathe; David J Mangelsdorf; Peter Tontonoz
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.
The Journal of biological chemistry 2003;278(12):10443-9.
2003: Bryan A Laffitte; Sean B Joseph; Mingyi Chen; Antonio Castrillo; Joyce J Repa; DAMIEN WILPITZ; David Mangelsdorf; Peter Tontonoz
The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.
Molecular and cellular biology 2003;23(6):2182-91.
2003: Sean B Joseph; Antonio Castrillo; Bryan A Laffitte; David J Mangelsdorf; Peter Tontonoz
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.
Nature medicine 2003;9(2):213-9.
2002: Jun Xu; Gary Xiao; Chuck Trujillo; Vicky Chang; Lilia Blanco; Sean B Joseph; Sara Bassilian; Mohammed F Saad; Peter Tontonoz; W N Paul Lee; Irwin Kurland
Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production.
The Journal of biological chemistry 2002;277(52):50237-44.
2002: Rajendra K Tangirala; Eric D Bischoff; Sean B Joseph; Brandee L Wagner; Robert Walczak; Bryan A Laffitte; Chris L Daige; Diane Thomas; Richard A Heyman; David J Mangelsdorf; Xuping Wang; Aldons J Lusis; Peter Tontonoz; Ira G Schulman
Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11896-901.
2002: Puiying A Mak; Bryan A Laffitte; Catherine Desrumaux; Sean B Joseph; Linda K Curtiss; David J Mangelsdorf; Peter Tontonoz; Peter A Edwards
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
The Journal of biological chemistry 2002;277(35):31900-8.
2002: Sean B Joseph; Elaine McKilligin; Liming Pei; Michael A Watson; Alan R Collins; Bryan A Laffitte; Mingyi Chen; Grace Noh; Joanne Goodman; Graham N Hagger; Jonathan Tran; Timothy K Tippin; Xuping Wang; Aldons J Lusis; Willa A Hsueh; Ronald E Law; Jon L Collins; Timothy M Willson; Peter Tontonoz
Synthetic LXR ligand inhibits the development of atherosclerosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7604-9.
2002: Sean B Joseph; Bryan A Laffitte; Parthive H Patel; Michael A Watson; Karen E Matsukuma; Robert Walczak; Jon L Collins; Timothy F Osborne; Peter Tontonoz
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.
The Journal of biological chemistry 2002;277(13):11019-25.
2001: Bryan A Laffitte; Sean B Joseph; Robert Walczak; Liming Pei; DAMIEN WILPITZ; Jon L Collins; Peter Tontonoz
Autoregulation of the human liver X receptor alpha promoter.
Molecular and cellular biology 2001;21(22):7558-68.
2001: Bryan A Laffitte; Joyce J Repa; Sean B Joseph; DAMIEN WILPITZ; Heidi R Kast; David J Mangelsdorf; Peter Tontonoz
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):507-12.
2001: Ajay Chawla; William A Boisvert; C H Lee; Bryan A Laffitte; Y Barak; Sean B Joseph; Debbie Liao; L Nagy; Peter A Edwards; Linda K Curtiss; Ronald M Evans; Peter Tontonoz
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.
Molecular cell 2001;7(1):161-71.
2000: A Venkateswaran; Bryan A Laffitte; Sean B Joseph; Puiying A Mak; DAMIEN WILPITZ; Peter A Edwards; Peter Tontonoz
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12097-102.