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Harish Joshi

Research Profile

Chemicals & Drugs

Anatomy

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Mouse

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Physiology

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Fluorescent Antibody Technique

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Publications

TOP 3
Shiwang Li; Vincent W Yang; Agnieszka B Bialkowska; Usha Bughani; Amr M Ghaleb; Jing He; Harish C Joshi
Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model.
Pradeep K Naik; Surya N Vangapandu; Ritu Aneja; Manu Lopus; Harish C Joshi
In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).
Shiwang Li; Shuai Li; Shaotao Tang; Qiangsong Tong; Guoqing Cao; Jing He; Harish C Joshi
Noscapine induced apoptosis via downregulation of survivin in human neuroblastoma cells having wild type or null p53.

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All Publications

2012: Shiwang Li; Vincent W Yang; Agnieszka B Bialkowska; Usha Bughani; Amr M Ghaleb; Jing He; Harish C Joshi
Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model.
International journal of cancer. Journal international du cancer 2012;131(6):1435-44.
2012: Pradeep K Naik; Surya N Vangapandu; Ritu Aneja; Manu Lopus; Harish C Joshi
In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).
Journal of computer-aided molecular design 2012;26(2):233-47.
2012: Shiwang Li; Shuai Li; Shaotao Tang; Qiangsong Tong; Guoqing Cao; Jing He; Harish C Joshi
Noscapine induced apoptosis via downregulation of survivin in human neuroblastoma cells having wild type or null p53.
PloS one 2012;7(7):e40076.
2011: Pradeep K Naik; Seneha Santoshi; Ankit Rai; Harish C Joshi
Molecular modelling and competition binding study of Br-noscapine and colchicine provide insight into noscapinoid-tubulin binding site.
Journal of molecular graphics & modelling 2011;29(7):947-55.
2011: Pradeep K Naik; Biswa Prasun Chatterji; Surya N Vangapandu; Ritu Aneja; Ramesh Chandra; Srinivas Kanteveri; Harish C Joshi
Rational design, synthesis and biological evaluations of amino-noscapine: a high affinity tubulin-binding noscapinoid.
Journal of computer-aided molecular design 2011;25(5):443-54.
2009: Usha Bughani; Shiwang Li; Harish C Joshi
Recent patents reveal microtubules as persistent promising target for novel drug development for cancers.
Recent patents on anti-infective drug discovery 2009;4(3):164-82.
2008: Ritu Aneja; Min Liu; Clayton Yates; Jinmin Gao; Xin Dong; Binfei Zhou; Surya N Vangapandu; Jun Zhou; Harish C Joshi
Multidrug resistance-associated protein-overexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agent.
Cancer research 2008;68(5):1495-503.
2007: Ritu Aneja; Vandana Kalia; Rafi Ahmed; Harish C Joshi
Nonimmunosuppressive chemotherapy: EM011-treated mice mount normal T-cell responses to an acute lymphocytic choriomeningitis virus infection.
Molecular cancer therapeutics 2007;6(11):2891-9.
2007: Ritu Aneja; Neerupma Dhiman; Jyoti Idnani; Anshumali Awasthi; Sudershan K Arora; Ramesh Chandra; Harish C Joshi
Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent.
Cancer chemotherapy and pharmacology 2007;60(6):831-9.
2007: Min Liu; Dengwen Li; Ritu Aneja; Harish C Joshi; Songbo Xie; Chao Zhang; Jun Zhou
PO(2)-dependent differential regulation of multidrug resistance 1 gene expression by the c-Jun NH2-terminal kinase pathway.
The Journal of biological chemistry 2007;282(24):17581-6.
2007: Ritu Aneja; Amr M Ghaleb; Jun Zhou; Yang Vincent; Harish C Joshi
p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells.
Cancer research 2007;67(8):3862-70.
2006: Ritu Aneja; Surya N Vangapandu; Harish C Joshi
Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog.
Bioorganic & medicinal chemistry 2006;14(24):8352-8.
2006: Ritu Aneja; Jun Zhou; Binfei Zhou; Ramesh Chandra; Harish C Joshi
Treatment of hormone-refractory breast cancer: apoptosis and regression of human tumors implanted in mice.
Molecular cancer therapeutics 2006;5(9):2366-77.
2006: Ritu Aneja; Surya N Vangapandu; Manu Lopus; Vijaya G Viswesarappa; Neerupma Dhiman; Akhilesh Verma; Ramesh Chandra; Dulal Panda; Harish C Joshi
Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.
Biochemical pharmacology 2006;72(4):415-26.
2006: Min Liu; Ritu Aneja; Chunyong Liu; Lei Sun; Jinmin Gao; Hongxia Wang; Jin-Tang Dong; vasiliki sarli; Athanassios Giannis; Harish C Joshi; Jun Zhou
Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells.
The Journal of biological chemistry 2006;281(26):18090-7.
2006: Surya N Vangapandu; Ritu Aneja; Ramesh Chandra; Harish C Joshi
Recent patents on proteases and kinases as anti-infective agents: a review.
Recent patents on anti-infective drug discovery 2006;1(2):209-24.
2006: Ritu Aneja; Surya N Vangapandu; Manu Lopus; Ramesh Chandra; Dulal Panda; Harish C Joshi
Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma.
Molecular pharmacology 2006;69(6):1801-9.
2006: Ritu Aneja; Manu Lopus; Jun Zhou; Surya N Vangapandu; Amr M Ghaleb; Joyce Yao; James Nettles; Binfei Zhou; Meenakshi Gupta; Dulal Panda; Ramesh Chandra; Harish C Joshi
Rational design of the microtubule-targeting anti-breast cancer drug EM015.
Cancer research 2006;66(7):3782-91.
2006: Ritu Aneja; Jun Zhou; Surya N Vangapandu; Binfei Zhou; Ramesh Chandra; Harish C Joshi
Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011.
Blood 2006;107(6):2486-92.
2006: Jun Zhou; Min Liu; Ritu Aneja; Ramesh Chandra; Hermann Lage; Harish C Joshi
Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase.
Cancer research 2006;66(1):445-52.
2005: Jun Zhou; Min Liu; Roopa Luthra; Jeremy Jones; Ritu Aneja; Ramesh Chandra; Rajeshwar Tekmal; Harish C Joshi
EM012, a microtubule-interfering agent, inhibits the progression of multidrug-resistant human ovarian cancer both in cultured cells and in athymic nude mice.
Cancer chemotherapy and pharmacology 2005;55(5):461-5.
2004: Jun Zhou; Min Liu; Ritu Aneja; Ramesh Chandra; Harish C Joshi
Enhancement of paclitaxel-induced microtubule stabilization, mitotic arrest, and apoptosis by the microtubule-targeting agent EM012.
Biochemical pharmacology 2004;68(12):2435-41.
2004: Jaren W Landen; Vincent Hau; Mingshen Wang; Thomas Davis; Brian Ciliax; Bruce H Wainer; Erwin Van Meir; Jonathan D Glass; Harish C Joshi; David R Archer
Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5187-201.
2004: Elizabeth E Stillwell; Jun Zhou; Harish C Joshi
Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation.
Cell cycle (Georgetown, Tex.) 2004;3(7):923-30.
2003: Paula M Checchi; James Nettles; Jun Zhou; James P Snyder; Harish C Joshi
Microtubule-interacting drugs for cancer treatment.
Trends in pharmacological sciences 2003;24(7):361-5.
2003: Jun Zhou; Kamlesh Gupta; Shefali Aggarwal; Ritu Aneja; Ramesh Chandra; Dulal Panda; Harish C Joshi
Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation.
Molecular pharmacology 2003;63(4):799-807.
2002: Jun Zhou; Kamlesh Gupta; Joyce Yao; Keqiang Ye; Dulal Panda; Paraskevi Giannakakou; Harish C Joshi
Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine.
The Journal of biological chemistry 2002;277(42):39777-85.
2002: Jun Zhou; Joyce Yao; Harish C Joshi
Attachment and tension in the spindle assembly checkpoint.
Journal of cell science 2002;115(Pt 18):3547-55.
2002: Jaren W Landen; Roland Lang; Steve J McMahon; Nasser Rusan; Anne-Marie Yvon; Ashley W Adams; Mia D Sorcinelli; Ross Campbell; Paola Bonaccorsi; John C Ansel; David R Archer; Patricia Wadsworth; Cheryl A Armstrong; Harish C Joshi
Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma.
Cancer research 2002;62(14):4109-14.
2002: Jun Zhou; Dulal Panda; Jaren W Landen; Leslie Wilson; Harish C Joshi
Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint.
The Journal of biological chemistry 2002;277(19):17200-8.
2002: Jun Zhou; Hong-Bing Shu; Harish C Joshi
Regulation of tubulin synthesis and cell cycle progression in mammalian cells by gamma-tubulin-mediated microtubule nucleation.
Journal of cellular biochemistry 2002;84(3):472-83.
2001: Keqiang Ye; Jun Zhou; Jaren W Landen; E M Bradbury; Harish C Joshi
Sustained activation of p34(cdc2) is required for noscapine-induced apoptosis.
The Journal of biological chemistry 2001;276(50):46697-700.
2001: Triscia W Hendrickson; Joyce Yao; S Bhadury; Anita H Corbett; Harish C Joshi
Conditional mutations in gamma-tubulin reveal its involvement in chromosome segregation and cytokinesis.
Molecular biology of the cell 2001;12(8):2469-81.
2001: Q Li; D Hansen; A Killilea; Harish C Joshi; R E Palazzo; R Balczon
Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1.
Journal of cell science 2001;114(Pt 4):797-809.
2001: Harish C Joshi; J Zhou
Gamma tubulin and microtubule nucleation in mammalian cells.
Methods in cell biology 2001;67():179-93.
2000: Harish C Joshi; J Zhou
Noscapine and analogues as potential chemotherapeutic agents.
Drug news & perspectives 2000;13(9):543-6.
2000: Yong Ke; Keqiang Ye; H E Grossniklaus; David R Archer; Harish C Joshi; Judith A Kapp
Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses.
Cancer immunology, immunotherapy : CII 2000;49(4-5):217-25.
1998: Keqiang Ye; Yong Ke; N Keshava; J Shanks; Judith A Kapp; Rajeshwar Tekmal; John Petros; Harish C Joshi
Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1601-6.
1998: Harish C Joshi
Microtubule dynamics in living cells.
Current opinion in cell biology 1998;10(1):35-44.
1996: K E Miller; Harish C Joshi
Tubulin transport in neurons.
The Journal of cell biology 1996;133(6):1355-66.
1996: Harish C Joshi; B A Palevitz
gamma-Tubulin and microtubule organization in plants.
Trends in cell biology 1996;6(2):41-4.
1995: Q Li; Harish C Joshi
gamma-tubulin is a minus end-specific microtubule binding protein.
The Journal of cell biology 1995;131(1):207-14.
1995: H B Shu; Z Li; M J Palacios; Q Li; Harish C Joshi
A transient association of gamma-tubulin at the midbody is required for the completion of cytokinesis during the mammalian cell division.
Journal of cell science 1995;108 ( Pt 9)():2955-62.
1995: H B Shu; Harish C Joshi
Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cells.
The Journal of cell biology 1995;130(5):1137-47.
1995: Q Li; Yong Ke; Judith A Kapp; N Fertig; T A Medsger; Harish C Joshi
A novel cell-cycle-dependent 350-kDa nuclear protein: C-terminal domain sufficient for nuclear localization.
Biochemical and biophysical research communications 1995;212(1):220-8.
1995: B Liu; Harish C Joshi; B A Palevitz
Experimental manipulation of gamma-tubulin distribution in Arabidopsis using anti-microtubule drugs.
Cell motility and the cytoskeleton 1995;31(2):113-29.
1994: Harish C Joshi
Microtubule organizing centers and gamma-tubulin.
Current opinion in cell biology 1994;6(1):54-62.
1994: B Liu; Harish C Joshi; T J Wilson; Carolyn D Silflow; B A Palevitz; D P Snustad
gamma-Tubulin in Arabidopsis: gene sequence, immunoblot, and immunofluorescence studies.
The Plant cell 1994;6(2):303-14.
1994: F J Ahmad; Harish C Joshi; Victoria Frohlich; Peter W Baas
Inhibition of microtubule nucleation at the neuronal centrosome compromises axon growth.
Neuron 1994;12(2):271-80.
1993: Harish C Joshi
Gamma-tubulin: the hub of cellular microtubule assemblies.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(10):637-43.
1993: Harish C Joshi; Peter W Baas
A new perspective on microtubules and axon growth.
The Journal of cell biology 1993;121(6):1191-6.
1993: Lawrence J Rizzolo; Harish C Joshi
Apical orientation of the microtubule organizing center and associated gamma-tubulin during the polarization of the retinal pigment epithelium in vivo.
Developmental biology 1993;157(1):147-56.
1993: B Liu; J Marc; Harish C Joshi; B A Palevitz
A gamma-tubulin-related protein associated with the microtubule arrays of higher plants in a cell cycle-dependent manner.
Journal of cell science 1993;104 ( Pt 4)():1217-28.
1993: M J Palacios; Harish C Joshi; C Simerly; Gerald Schatten
Gamma-tubulin reorganization during mouse fertilization and early development.
Journal of cell science 1993;104 ( Pt 2)():383-9.
1993: A R McDonald; B Liu; Harish C Joshi; B A Palevitz
Gamma-tubulin is associated with a cortical-microtubule-organizing zone in the developing guard cells of Allium cepa L.
Planta 1993;191(3):357-61.
1993: Harish C Joshi
Immunogold electron microscopy: mapping tubulin isotypes on neurite microtubules.
Methods in cell biology 1993;37():259-81.
1992: Peter W Baas; Harish C Joshi
Gamma-tubulin distribution in the neuron: implications for the origins of neuritic microtubules.
The Journal of cell biology 1992;119(1):171-8.
1992: Harish C Joshi; M J Palacios; L McNamara; D W Cleveland
Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation.
Nature 1992;356(6364):80-3.