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Flora Jow

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Riccardo Zanaletti; Laura Bettinetti; Cristiana Castaldo; Ilaria Ceccarelli; Giuseppe Cocconcelli; thomas Comery; John Dunlop; Eva Genesio; Chiara Ghiron; Simon N Haydar; Flora Jow; laura maccari; Iolanda Micco; Arianna Nencini; Carmela Pratelli; Carla Scali; Elisa Turlizzi; Michela Valacchi
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.
Riccardo Zanaletti; Laura Bettinetti; Cristiana Castaldo; Giuseppe Cocconcelli; Thomas Comery; John Dunlop; Giovanni Gaviraghi; Chiara Ghiron; Simon N Haydar; Flora Jow; laura maccari; Iolanda Micco; Arianna Nencini; Carla Scali; Elisa Turlizzi; Michela Valacchi
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).
Karen L Marquis; Rachel L Navarra; Claudine Pulicicchio; Renza Roncarati; Carla Scali; Georg C Terstappen; Chiara Ghiron; Steven M Grauer; Simon Haydar; Flora Jow; Cody Kelley; Julie A Brennan; thomas Comery; John Dunlop
Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.

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All Publications

2012: Riccardo Zanaletti; Laura Bettinetti; Cristiana Castaldo; Ilaria Ceccarelli; Giuseppe Cocconcelli; thomas Comery; John Dunlop; Eva Genesio; Chiara Ghiron; Simon N Haydar; Flora Jow; laura maccari; Iolanda Micco; Arianna Nencini; Carmela Pratelli; Carla Scali; Elisa Turlizzi; Michela Valacchi
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.
Journal of medicinal chemistry 2012;55(22):10277-81.
2012: Riccardo Zanaletti; Laura Bettinetti; Cristiana Castaldo; Giuseppe Cocconcelli; Thomas Comery; John Dunlop; Giovanni Gaviraghi; Chiara Ghiron; Simon N Haydar; Flora Jow; laura maccari; Iolanda Micco; Arianna Nencini; Carla Scali; Elisa Turlizzi; Michela Valacchi
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).
Journal of medicinal chemistry 2012;55(10):4806-23.
2011: Karen L Marquis; Rachel L Navarra; Claudine Pulicicchio; Renza Roncarati; Carla Scali; Georg C Terstappen; Chiara Ghiron; Steven M Grauer; Simon Haydar; Flora Jow; Cody Kelley; Julie A Brennan; thomas Comery; John Dunlop
Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.
Psychopharmacology 2011;218(4):635-47.
2009: John Dunlop; Tim Lock; Brian Jow; Fabrizio Sitzia; Steven M Grauer; Flora Jow; Angela Kramer; Mark Bowlby; Andrew Randall; Dianne Kowal; Adam Gilbert; thomas Comery; James Larocque; Veronica Soloveva; Jon Brown; Renza Roncarati
Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide).
The Journal of pharmacology and experimental therapeutics 2009;328(3):766-76.
2009: Jason M Dwyer; Stacey J Sukoff Rizzo; Sarah J Neal; Qian Lin; Flora Jow; Robert L Arias; Sharon Rosenzweig-Lipson; John Dunlop; Chad E Beyer
Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models.
Psychopharmacology 2009;203(1):41-52.
2008: Qiang Lu; Joseph Peevey; Flora Jow; Michael M Monaghan; Grace Mendoza; Howard Zhang; Jerome Wu; Callain Y Kim; James Bicksler; Lynn Greenblatt; Stephen S Lin; Wayne Childers; Mark Bowlby
Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators).
Bioorganic & medicinal chemistry 2008;16(6):3067-75.
2007: Flora Jow; Ru Shen; Pranab K Chanda; Eugene Tseng; Howard Zhang; Jeffrey Kennedy; John Dunlop; Mark Bowlby
Validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel enhancers using IonWorks HT.
Journal of biomolecular screening 2007;12(8):1059-67.
2006: Flora Jow; Eugene Tseng; Taneya Maddox; Ru Shen; Dianne Kowal; John Dunlop; Belew Mekonnen; KeWei Wang
Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).
Assay and drug development technologies 2006;4(4):443-50.
2006: Flora Jow; Lan He; Angela Kramer; Joseph Hinson; Mark Bowlby; John Dunlop; Kewei Wang
Validation of DRG-like F11 cells for evaluation of KCNQ/M-channel modulators.
Assay and drug development technologies 2006;4(1):49-56.
2005: Mark Bowlby; Pranab K Chanda; Wade Edris; Joseph Hinson; Flora Jow; Alan H Katz; Jeffrey Kennedy; Girija Krishnamurthy; Keith Pitts; Kevin Ryan; Howard Zhang; Lynne Greenblatt
Identification and characterization of small molecule modulators of KChIP/Kv4 function.
Bioorganic & medicinal chemistry 2005;13(22):6112-9.
2004: Flora Jow; Zhi-Hao Zhang; David C Kopsco; Karen C Carroll; Kewei Wang
Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvbeta1.1 A-type K+ channels.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15535-40.
2004: Kewei Wang; Beal McIlvain; Eugene Tseng; Dianne Kowal; Flora Jow; Ru Shen; Howard Zhang; Qin Shan; Lan He; Diana Chen; Qiang Lu; John Dunlop
Validation of an atomic absorption rubidium ion efflux assay for KCNQ/M-channels using the ion Channel Reader 8000.
Assay and drug development technologies 2004;2(5):525-34.
2004: Flora Jow; Doreen Chiu; Heng-Keang Lim; Tom Novak; Stephen Lin
Production of GABA by cultured hippocampal glial cells.
Neurochemistry international 2004;45(2-3):273-83.
2004: Robert H Scannevin; KeWei Wang; Flora Jow; Jennifer Megules; David C Kopsco; Wade Edris; Karen C Carroll; Qiang Lü; Weixin Xu; Zhangbao Xu; Alan H Katz; Stephane Olland; Laura Lin; Meggin Taylor; Mark L Stahl; Karl Malakian; William S Somers; Lidia Mosyak; Mark Bowlby; Pranab K Chanda; Kenneth J Rhodes
Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron 2004;41(4):587-98.
2000: Flora Jow; R Numann
Histamine increases [Ca(2+)](in) and activates Ca-K and nonselective cation currents in cultured human capillary endothelial cells.
The Journal of membrane biology 2000;173(2):107-16.
1999: Flora Jow; R Numann
Fluid flow modulates calcium entry and activates membrane currents in cultured human aortic endothelial cells.
The Journal of membrane biology 1999;171(2):127-39.
1999: Flora Jow; K Sullivan; P Sokol; R Numann
Induction of Ca2+-activated K+ current and transient outward currents in human capillary endothelial cells.
The Journal of membrane biology 1999;167(1):53-64.
1998: Flora Jow; R Numann
Divalent ion block of inward rectifier current in human capillary endothelial cells and effects on resting membrane potential.
The Journal of physiology 1998;512 ( Pt 1)():119-28.
1998: Z H Zhang; Flora Jow; R Numann; Joseph Hinson
The airway-epithelium: a novel site of action by guanylin.
Biochemical and biophysical research communications 1998;244(1):50-6.