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Alexandra Joyner

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Megan Bowers; Liane Eng; Xiaozhong Bao; Zhimin Lao; Susan Mackem; Elyn Riedel; Rowena K Turnbull; Alexandra L Joyner
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Grant D Orvis; Jenessa B Smith; Kamila Szulc; Daniel Turnbull; Sandra L Wilson; Luis Humberto Barraza; Andrea L Hartzell; Alexandra L Joyner
The engrailed homeobox genes are required in multiple cell lineages to coordinate sequential formation of fissures and growth of the cerebellum.
Sandra L Wilson; Anna Kalinovsky; Grant D Orvis; Alexandra L Joyner
Spatially restricted and developmentally dynamic expression of engrailed genes in multiple cerebellar cell types.

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All Publications

2012: Megan Bowers; Liane Eng; Xiaozhong Bao; Zhimin Lao; Susan Mackem; Elyn Riedel; Rowena K Turnbull; Alexandra L Joyner
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Developmental biology 2012;370(1):110-24.
2012: Grant D Orvis; Jenessa B Smith; Kamila Szulc; Daniel Turnbull; Sandra L Wilson; Luis Humberto Barraza; Andrea L Hartzell; Alexandra L Joyner
The engrailed homeobox genes are required in multiple cell lineages to coordinate sequential formation of fissures and growth of the cerebellum.
Developmental biology 2012;367(1):25-39.
2011: Sandra L Wilson; Anna Kalinovsky; Grant D Orvis; Alexandra L Joyner
Spatially restricted and developmentally dynamic expression of engrailed genes in multiple cerebellar cell types.
Cerebellum (London, England) 2011;10(3):356-72.
2011: Anamaria Sudarov; Rowena K Turnbull; Francois Guillemot; Euiseok J Kim; Melanie Lebel-Potter; Alexandra L Joyner
Ascl1 genetics reveals insights into cerebellum local circuit assembly.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(30):11055-69.
2011: Xin Yu; Brian J Nieman; Anamaria Sudarov; Kamila Szulc; Davood J Abdollahian; Nitin Bhatia; Anil K Lalwani; Alexandra L Joyner; Daniel Turnbull
Morphological and functional midbrain phenotypes in Fibroblast Growth Factor 17 mutant mice detected by Mn-enhanced MRI.
NeuroImage 2011;56(3):1251-8.
2011: Isaac Brownell; Elizabeth Guevara; C Brian Bai; Cynthia A Loomis; Alexandra L Joyner
Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells.
Cell stem cell 2011;8(5):552-65.
2010: Kerstin Seidel; Christina P Ahn; David Lyons; Alexander Nee; Kevin Ting; Isaac Brownell; Tim Cao; Richard A D Carano; Tom Curran; Markus Schober; Elaine Fuchs; Alexandra L Joyner; Gail R Martin; Frederic J de Sauvage; Ophir D Klein
Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.
Development (Cambridge, England) 2010;137(22):3753-61.
2010: A Denise R Garcia; Ralitsa Petrova; Liane Eng; Alexandra L Joyner
Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(41):13597-608.
2010: Roy Sillitoe; Michael W Vogel; Alexandra L Joyner
Engrailed homeobox genes regulate establishment of the cerebellar afferent circuit map.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(30):10015-24.
2010: Brian J Nieman; Jeffrey Y Shyu; Joe J Rodriguez; A Denise Garcia; Alexandra L Joyner; Daniel Turnbull
In vivo MRI of neural cell migration dynamics in the mouse brain.
NeuroImage 2010;50(2):456-64.
2010: Yulan Cheng; Anamaria Sudarov; Kamila Szulc; Sema K Sgaier; Daniel Stephen; Daniel H Turnbull; Alexandra L Joyner
The Engrailed homeobox genes determine the different foliation patterns in the vermis and hemispheres of the mammalian cerebellum.
Development (Cambridge, England) 2010;137(3):519-29.
2010: Emilie Legué; Alexandra L Joyner
Genetic fate mapping using site-specific recombinases.
Methods in enzymology 2010;477():153-81.
2009: Cesar A Berrios-Otero; Youssef Wadghiri; Brian J Nieman; Alexandra L Joyner; Daniel Turnbull
Three-dimensional micro-MRI analysis of cerebral artery development in mouse embryos.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2009;62(6):1431-9.
2009: Tatsuya Sato; Alexandra L Joyner
The duration of Fgf8 isthmic organizer expression is key to patterning different tectal-isthmo-cerebellum structures.
Development (Cambridge, England) 2009;136(21):3617-26.
2009: Roy Sillitoe; N Gopal; Alexandra L Joyner
Embryonic origins of ZebrinII parasagittal stripes and establishment of topographic Purkinje cell projections.
Neuroscience 2009;162(3):574-88.
2008: Roy Sillitoe; Daniel Stephen; Zhimin Lao; Alexandra L Joyner
Engrailed homeobox genes determine the organization of Purkinje cell sagittal stripe gene expression in the adult cerebellum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12150-62.
2008: Natalie A Thomas; Marco Koudijs; Fredericus J M van Eeden; Alexandra L Joyner; Deborah Yelon
Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential.
Development (Cambridge, England) 2008;135(22):3789-99.
2008: Sandra Blaess; Daniel Stephen; Alexandra L Joyner
Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.
Development (Cambridge, England) 2008;135(12):2093-103.
2008: M Albert Basson; Diego Echevarria; Christina Petersen Ahn; Anamaria Sudarov; Alexandra L Joyner; Ivor Mason; Salvador Martinez; Gail R Martin
Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development.
Development (Cambridge, England) 2008;135(5):889-98.
2007: Sema K Sgaier; Zhimin Lao; Melissa P Villanueva; Frada Berenshteyn; Daniel Stephen; Rowena K Turnbull; Alexandra L Joyner
Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteins.
Development (Cambridge, England) 2007;134(12):2325-35.
2007: Anamaria Sudarov; Alexandra L Joyner
Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers.
Neural development 2007;2():26.
2007: Roy Sillitoe; Alexandra L Joyner
Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum.
Annual review of cell and developmental biology 2007;23():549-77.
2006: Marc Fuccillo; Alexandra L Joyner; Gord Fishell
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development.
Nature reviews. Neuroscience 2006;7(10):772-83.
2006: Alexandra L Joyner; Mark Zervas
Genetic inducible fate mapping in mouse: establishing genetic lineages and defining genetic neuroanatomy in the nervous system.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(9):2376-85.
2006: Radhika Atit; Sema K Sgaier; Othman A Mohamed; Makoto M Taketo; Daniel Dufort; Alexandra L Joyner; Lee Niswander; Ronald A Conlon
Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse.
Developmental biology 2006;296(1):164-76.
2006: Yong Pan; C Brian Bai; Alexandra L Joyner; Baolin Wang
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.
Molecular and cellular biology 2006;26(9):3365-77.
2006: Sandra Blaess; JoMichelle D Corrales; Alexandra L Joyner
Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region.
Development (Cambridge, England) 2006;133(9):1799-809.
2006: JoMichelle D Corrales; Sandra Blaess; Eamonn M Mahoney; Alexandra L Joyner
The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation.
Development (Cambridge, England) 2006;133(9):1811-21.
2006: Shaun K Olsen; James Y H Li; Carrie Bromleigh; Anna V Eliseenkova; Omar A Ibrahimi; Zhimin Lao; Fuming Zhang; Robert J Linhardt; Alexandra L Joyner; Moosa Mohammadi
Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.
Genes & development 2006;20(2):185-98.
2006: Debora Rapaport; Wojtek Auerbach; Naava Naslavsky; Metsada Pasmanik-Chor; Emilia Galperin; amos fein; Steve Caplan; Alexandra L Joyner; Mia Horowitz
Recycling to the plasma membrane is delayed in EHD1 knockout mice.
Traffic (Copenhagen, Denmark) 2006;7(1):52-60.
2005: Sohyun Ahn; Alexandra L Joyner
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog.
Nature 2005;437(7060):894-7.
2005: Karoline J Briegel; H Scott Baldwin; Jonathan A Epstein; Alexandra L Joyner
Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh.
Development (Cambridge, England) 2005;132(14):3305-16.
2005: Hiromichi Kimura; Daniel Stephen; Alexandra L Joyner; Tom Curran
Gli1 is important for medulloblastoma formation in Ptc1+/- mice.
Oncogene 2005;24(25):4026-36.
2005: James Y H Li; Zhimin Lao; Alexandra L Joyner
New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression.
Development (Cambridge, England) 2005;132(8):1971-81.
2005: Tsadok Cohen; Wojtek Auerbach; Liat Ravid; Jacques Bodennec; amos fein; Anthony H Futerman; Alexandra L Joyner; Mia Horowitz
The exon 8-containing prosaposin gene splice variant is dispensable for mouse development, lysosomal function, and secretion.
Molecular and cellular biology 2005;25(6):2431-40.
2005: Sema K Sgaier; Sandrine Millet; Melissa P Villanueva; Frada Berenshteyn; Christian Song; Alexandra L Joyner
Morphogenetic and cellular movements that shape the mouse cerebellum; insights from genetic fate mapping.
Neuron 2005;45(1):27-40.
2005: Mark Zervas; Sandra Blaess; Alexandra L Joyner
Classical embryological studies and modern genetic analysis of midbrain and cerebellum development.
Current topics in developmental biology 2005;69():101-38.
2004: Youssef Wadghiri; Jeffrey A Blind; Xiaohong Duan; Clement Moreno; xin yu; Alexandra L Joyner; Daniel Turnbull
Manganese-enhanced magnetic resonance imaging (MEMRI) of mouse brain development.
NMR in biomedicine 2004;17(8):613-9.
2004: Tatsuya Sato; Alexandra L Joyner; Harukazu Nakamura
How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development?
Development, growth & differentiation 2004;46(6):487-94.
2004: JoMichelle D Corrales; Gina L Rocco; Sandra Blaess; Qiuxia Guo; Alexandra L Joyner
Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development.
Development (Cambridge, England) 2004;131(22):5581-90.
2004: Christopher P Austin; James F Battey; Allan Bradley; Maja Bucan; Mario R Capecchi; Francis S Collins; William F Dove; Geoffrey Duyk; Susan Dymecki; Janan T Eppig; Franziska B Grieder; Nathaniel Heintz; Geoff Hicks; Thomas R Insel; Alexandra L Joyner; Beverly H Koller; K C Kent Lloyd; Terry Magnuson; Mark W Moore; Andras Nagy; Jonathan D Pollock; Allen D Roses; Arthur T Sands; Brian Seed; William C Skarnes; Jay Snoddy; Philippe Soriano; David J Stewart; Francis Stewart; Bruce Stillman; Harold Varmus; Lyuba Varticovski; Inder M Verma; Thomas F Vogt; Harald von Melchner; Jan Witkowski; Richard P Woychik; Wolfgang Wurst; George D Yancopoulos; Stephen G Young; Brian Zambrowicz
The knockout mouse project.
Nature genetics 2004;36(9):921-4.
2004: Sohyun Ahn; Alexandra L Joyner
Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.
Cell 2004;118(4):505-16.
2004: Mark Zervas; Sandrine Millet; Sohyun Ahn; Alexandra L Joyner
Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1.
Neuron 2004;43(3):345-57.
2004: Kevin M Hopkins; Wojtek Auerbach; Xiang Yuan Wang; M Prakash Hande; Haiying Hang; Debra J Wolgemuth; Alexandra L Joyner; Howard B Lieberman
Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality.
Molecular and cellular biology 2004;24(16):7235-48.
2004: C Brian Bai; Daniel Stephen; Alexandra L Joyner
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.
Developmental cell 2004;6(1):103-15.
2003: Qiuxia Guo; Cynthia Loomis; Alexandra L Joyner
Fate map of mouse ventral limb ectoderm and the apical ectodermal ridge.
Developmental biology 2003;264(1):166-78.
2003: Aimin Liu; James Y H Li; Carrie Bromleigh; Zhimin Lao; Lee Niswander; Alexandra L Joyner
FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors.
Development (Cambridge, England) 2003;130(25):6175-85.
2003: Shiaoching Gong; Chen Zheng; Martin L Doughty; Kasia Losos; Nicholas Didkovsky; Uta B Schambra; Norma J Nowak; Alexandra L Joyner; Gabrielle Leblanc; Mary E Hatten; Nathaniel Heintz
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.
Nature 2003;425(6961):917-25.
2003: Anna B Auerbach; Rada Norinsky; Weilan Ho; Kasia Losos; Qiuxia Guo; Samprit Chatterjee; Alexandra L Joyner
Strain-dependent differences in the efficiency of transgenic mouse production.
Transgenic research 2003;12(1):59-69.
2002: Howard L Weiner; Richard Bakst; Marc S Hurlbert; Jason Ruggiero; Esther Ahn; Wing Shing Lee; Daniel Stephen; David Zagzag; Alexandra L Joyner; Daniel Turnbull
Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1.
Cancer research 2002;62(22):6385-9.
2002: Misako Nakashima; Naoko Tanese; Masataka Ito; Wojtek Auerbach; C Bai; T Furukawa; Takashi Toyono; Akifumi Akamine; Alexandra L Joyner
A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.
Mechanisms of development 2002;119(1):21-34.
2002: Michael G Ziegler; Xuping Bao; Brian P Kennedy; Alexandra L Joyner; Robert Enns
Location, development, control, and function of extraadrenal phenylethanolamine N-methyltransferase.
Annals of the New York Academy of Sciences 2002;971():76-82.
2002: C Brian Bai; Wojtek Auerbach; Joon S Lee; Daniel Stephen; Alexandra L Joyner
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.
Development (Cambridge, England) 2002;129(20):4753-61.
2002: James Y H Li; Zhimin Lao; Alexandra L Joyner
Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer.
Neuron 2002;36(1):31-43.
2001: C Brian Bai; Alexandra L Joyner
Gli1 can rescue the in vivo function of Gli2.
Development (Cambridge, England) 2001;128(24):5161-72.
2001: James Y H Li; Alexandra L Joyner
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression.
Development (Cambridge, England) 2001;128(24):4979-91.
2001: Wojtek Auerbach; Marc S Hurlbert; Paige Hilditch-Maguire; Youssef Wadghiri; Vanessa C Wheeler; S I Cohen; Alexandra L Joyner; Marcy E MacDonald; Daniel Turnbull
The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin.
Human molecular genetics 2001;10(22):2515-23.
2001: Karoline J Briegel; Alexandra L Joyner
Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development.
Developmental biology 2001;233(2):291-304.
2001: A Liu; Alexandra L Joyner
Early anterior/posterior patterning of the midbrain and cerebellum.
Annual review of neuroscience 2001;24():869-96.
2001: A Liu; Alexandra L Joyner
EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region.
Development (Cambridge, England) 2001;128(2):181-91.
2000: Alexandra L Joyner; A Liu; Sandrine Millet
Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer.
Current opinion in cell biology 2000;12(6):736-41.
2000: Wojtek Auerbach; Judy H Dunmore; Victoria Fairchild-Huntress; Q Fang; Anna B Auerbach; Dennis Huszar; Alexandra L Joyner
Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines.
BioTechniques 2000;29(5):1024-8, 1030, 1032.
2000: Douglas J Epstein; Lenka Martinu; J L Michaud; Kasia Losos; C Fan; Alexandra L Joyner
Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS.
Development (Cambridge, England) 2000;127(21):4701-9.
2000: Jenny Jongstra-Bilen; VL Misener; Chunjie Wang; Hedy H Ginzberg; A Auerbach; Alexandra L Joyner; Gregory P Downey; Jan Jongstra
LSP1 modulates leukocyte populations in resting and inflamed peritoneum.
Blood 2000;96(5):1827-35.
2000: R A Kimmel; Daniel Turnbull; V Blanquet; W Wurst; Cynthia Loomis; Alexandra L Joyner
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation.
Genes & development 2000;14(11):1377-89.
2000: H L Park; C Bai; KA Platt; Michael P Matise; A Beeghly; C C Hui; M Nakashima; Alexandra L Joyner
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.
Development (Cambridge, England) 2000;127(8):1593-605.
2000: Vanessa C Wheeler; JK White; Claire-Anne Gutekunst; Vladimir Vrbanac; M Weaver; Xiao-Jiang Li; S H Li; H Yi; Jean-Paul Vonsattel; James Gusella; Steven M Hersch; Wojtek Auerbach; Alexandra L Joyner; Marcy E MacDonald
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice.
Human molecular genetics 2000;9(4):503-13.
2000: D Li Song; Alexandra L Joyner
Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid-hindbrain expression.
Mechanisms of development 2000;90(2):155-65.
1999: Michael P Matise; Alexandra L Joyner
Gli genes in development and cancer.
Oncogene 1999;18(55):7852-9.
1999: A Liu; Kasia Losos; Alexandra L Joyner
FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate.
Development (Cambridge, England) 1999;126(21):4827-38.
1999: Sandrine Millet; K Campbell; Douglas J Epstein; Kasia Losos; E Harris; Alexandra L Joyner
A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer.
Nature 1999;401(6749):161-4.
1999: Michael P Matise; Marc J Lustig; Takeshi Sakurai; Martin Grumet; Alexandra L Joyner
Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord.
Development (Cambridge, England) 1999;126(16):3649-59.
1999: L Mintz; Emilia Galperin; Metsada Pasmanik-Chor; S Tulzinsky; Yael Bromberg; C A Kozak; Alexandra L Joyner; amos fein; Mia Horowitz
EHD1--an EH-domain-containing protein with a specific expression pattern.
Genomics 1999;59(1):66-76.
1999: Misako Nakashima; Takashi Toyono; Akifumi Akamine; Alexandra L Joyner
Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis.
Mechanisms of development 1999;80(2):185-9.
1999: Vanessa C Wheeler; Wojtek Auerbach; JK White; J Srinidhi; A Auerbach; A Ryan; Mabel P Duyao; Vladimir Vrbanac; M Weaver; James Gusella; Alexandra L Joyner; Marcy E MacDonald
Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse.
Human molecular genetics 1999;8(1):115-22.
1999: Douglas J Epstein; A P McMahon; Alexandra L Joyner
Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms.
Development (Cambridge, England) 1999;126(2):281-92.
1998: Peter Wenner; M P Matise; Alexandra L Joyner; Michael J O'Donovan
Physiological and molecular characterization of interneurons in the developing spinal cord.
Annals of the New York Academy of Sciences 1998;860():425-7.
1998: M C Hanks; Cynthia Loomis; E Harris; C X Tong; L Anson-Cartwright; A Auerbach; Alexandra L Joyner
Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development.
Development (Cambridge, England) 1998;125(22):4521-30.
1998: Michael P Matise; Douglas J Epstein; H L Park; KA Platt; Alexandra L Joyner
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.
Development (Cambridge, England) 1998;125(15):2759-70.
1998: A Liu; Alexandra L Joyner; Daniel Turnbull
Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells.
Mechanisms of development 1998;75(1-2):107-15.
1998: DL Zinyk; E H Mercer; E Harris; D J Anderson; Alexandra L Joyner
Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system.
Current biology : CB 1998;8(11):665-8.
1998: Cynthia Loomis; R A Kimmel; C X Tong; J Michaud; Alexandra L Joyner
Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs.
Development (Cambridge, England) 1998;125(6):1137-48.
1997: JK White; Wojtek Auerbach; Mabel P Duyao; Jean-Paul Vonsattel; James Gusella; Alexandra L Joyner; Marcy E MacDonald
Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion.
Nature genetics 1997;17(4):404-10.
1997: Barbara Kuemerle; Hadi Zanjani; Alexandra L Joyner; Karl Herrup
Pattern deformities and cell loss in Engrailed-2 mutant mice suggest two separate patterning events during cerebellar development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7881-9.
1997: Michael P Matise; Alexandra L Joyner
Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7805-16.
1997: K M Wassarman; M Lewandoski; K Campbell; Alexandra L Joyner; John L R Rubenstein; Salvador Martinez; Gail R Martin
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function.
Development (Cambridge, England) 1997;124(15):2923-34.
1997: KA Platt; J Michaud; Alexandra L Joyner
Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice.
Mechanisms of development 1997;62(2):121-35.
1997: M Wassef; Alexandra L Joyner
Early mesencephalon/metencephalon patterning and development of the cerebellum.
Perspectives on developmental neurobiology 1997;5(1):3-16.
1997: Rong Mo; A M Freer; DL Zinyk; Michael A Crackower; J Michaud; Hong-Qiang Heng; K W Chik; XM Shi; Lap-Chee Tsui; S H Cheng; Alexandra L Joyner; C c Hui
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.
Development (Cambridge, England) 1997;124(1):113-23.
1996: Alexander F Schier; Alexandra L Joyner; R Lehmann; William S Talbot
From screens to genes: prospects for insertional mutagenesis in zebrafish.
Genes & development 1996;10(24):3077-80.
1996: Louise A Scrocchi; T J Brown; N MaClusky; Patricia L Brubaker; A B Auerbach; Alexandra L Joyner; Daniel J Drucker
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.
Nature medicine 1996;2(11):1254-8.
1996: Michael W Vogel; Z Ji; K Millen; Alexandra L Joyner
The Engrailed-2 homeobox gene and patterning of spinocerebellar mossy fiber afferents.
Brain research. Developmental brain research 1996;96(1-2):210-8.
1996: C A Loomis; E Harris; J Michaud; W Wurst; M Hanks; Alexandra L Joyner
The mouse Engrailed-1 gene and ventral limb patterning.
Nature 1996;382(6589):360-3.
1996: Ming Chen; D J Tomkins; Wojtek Auerbach; Colin McKerlie; H Youssoufian; L Liu; Olga I Gan; Madeleine Carreau; A Auerbach; T Groves; Cynthia J Guidos; Melvin H Freedman; J Cross; D H Percy; John E Dick; Alexandra L Joyner; Manuel Buchwald
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia.
Nature genetics 1996;12(4):448-51.
1996: Lesley Forrester; Andras Nagy; M Sam; A Watt; L Stevenson; alan bernstein; Alexandra L Joyner; W Wurst
An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1677-82.
1996: R Gerlai; K J Millen; Karl Herrup; K Fabien; Alexandra L Joyner; J Roder
Impaired motor learning performance in cerebellar En-2 mutant mice.
Behavioral neuroscience 1996;110(1):126-33.
1996: D L Song; G Chalepakis; P Gruss; Alexandra L Joyner
Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene.
Development (Cambridge, England) 1996;122(2):627-35.
1996: Marcy E MacDonald; Mabel P Duyao; T Calzonetti; A Auerbach; A Ryan; G Barnes; J K White; Wojtek Auerbach; Jean-Paul Vonsattel; James Gusella; Alexandra L Joyner
Targeted inactivation of the mouse Huntington's disease gene homolog Hdh.
Cold Spring Harbor symposia on quantitative biology 1996;61():627-38.
1996: Alexandra L Joyner
Engrailed, Wnt and Pax genes regulate midbrain--hindbrain development.
Trends in genetics : TIG 1996;12(1):15-20.
1995: K J Millen; C C Hui; Alexandra L Joyner
A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum.
Development (Cambridge, England) 1995;121(12):3935-45.
1995: M Hanks; W Wurst; L Anson-Cartwright; A B Auerbach; Alexandra L Joyner
Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2.
Science (New York, N.Y.) 1995;269(5224):679-82.
1995: Mabel P Duyao; A B Auerbach; A Ryan; Francesca Persichetti; G T Barnes; S M McNeil; P Ge; Jean-Paul Vonsattel; James Gusella; Alexandra L Joyner
Inactivation of the mouse Huntington's disease gene homolog Hdh.
Science (New York, N.Y.) 1995;269(5222):407-10.
1995: Daniel Turnbull; T S Bloomfield; H S Baldwin; F Stuart Foster; Alexandra L Joyner
Ultrasound backscatter microscope analysis of early mouse embryonic brain development.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2239-43.
1995: F Guillemot; T Caspary; Shirley M Tilghman; N G Copeland; D J Gilbert; N A Jenkins; D J Anderson; Alexandra L Joyner; Janet Rossant; Andras Nagy
Genomic imprinting of Mash2, a mouse gene required for trophoblast development.
Nature genetics 1995;9(3):235-42.
1995: W Wurst; Janet Rossant; V Prideaux; M Kownacka; Alexandra L Joyner; D P Hill; F Guillemot; S Gasca; D Cado; A Auerbach
A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice.
Genetics 1995;139(2):889-99.
1994: V L Misener; C c Hui; I A Malapitan; ME Ittel; Alexandra L Joyner; Jan Jongstra
Expression of mouse LSP1/S37 isoforms. S37 is expressed in embryonic mesenchymal cells.
Journal of cell science 1994;107 ( Pt 12)():3591-600.
1994: F Guillemot; Andras Nagy; A Auerbach; Janet Rossant; Alexandra L Joyner
Essential role of Mash-2 in extraembryonic development.
Nature 1994;371(6495):333-6.
1994: W Wurst; A B Auerbach; Alexandra L Joyner
Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum.
Development (Cambridge, England) 1994;120(7):2065-75.
1994: C C Hui; Diane C Slusarski; K A Platt; R Holmgren; Alexandra L Joyner
Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.
Developmental biology 1994;162(2):402-13.
1994: K J Millen; W Wurst; Karl Herrup; Alexandra L Joyner
Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants.
Development (Cambridge, England) 1994;120(3):695-706.
1994: Alexandra L Joyner; F Guillemot
Gene targeting and development of the nervous system.
Current opinion in neurobiology 1994;4(1):37-42.
1994: Liching Lo; F Guillemot; Alexandra L Joyner; David J Anderson
MASH-1: a marker and a mutation for mammalian neural crest development.
Perspectives on developmental neurobiology 1994;2(2):191-201.
1993: F Guillemot; L C Lo; J E Johnson; A Auerbach; D J Anderson; Alexandra L Joyner
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.
Cell 1993;75(3):463-76.
1993: R Klein; Richard J Smeyne; W Wurst; L K Long; B A Auerbach; Alexandra L Joyner; Mariano Barbacid
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death.
Cell 1993;75(1):113-22.
1993: F Guillemot; Alexandra L Joyner
Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system.
Mechanisms of development 1993;42(3):171-85.
1993: C C Hui; Alexandra L Joyner
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.
Nature genetics 1993;3(3):241-6.
1993: C Logan; W Khoo; D Cado; Alexandra L Joyner
Two enhancer regions in the mouse En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts.
Development (Cambridge, England) 1993;117(3):905-16.
1993: Martin R Ralph; Alexandra L Joyner; M N Lehman
Culture and transplantation of the mammalian circadian pacemaker.
Journal of biological rhythms 1993;8 Suppl():S83-7.
1993: A Köhler; C Logan; Alexandra L Joyner; Maximilian Muenke
Regional assignment of the human homeobox-containing gene EN1 to chromosome 2q13-q21.
Genomics 1993;15(1):233-5.
1992: W C Skarnes; B A Auerbach; Alexandra L Joyner
A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice.
Genes & development 1992;6(6):903-18.
1992: Andrew P McMahon; Alexandra L Joyner; A Bradley; J A McMahon
The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum.
Cell 1992;69(4):581-95.
1992: C B Moens; A B Auerbach; Ronald A Conlon; Alexandra L Joyner; Janet Rossant
A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung.
Genes & development 1992;6(5):691-704.
1992: Alexandra L Joyner; A Auerbach; W C Skarnes
The gene trap approach in embryonic stem cells: the potential for genetic screens in mice.
Ciba Foundation symposium 1992;165():277-88; discussion 288-97.
1992: C Logan; M C Hanks; S Noble-Topham; D Nallainathan; N J Provart; Alexandra L Joyner
Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions.
Developmental genetics 1992;13(5):345-58.
1991: Alexandra L Joyner
Gene targeting and gene trap screens using embryonic stem cells: new approaches to mammalian development.
BioEssays : news and reviews in molecular, cellular and developmental biology 1991;13(12):649-56.
1991: Alexandra L Joyner; Karl Herrup; B A Auerbach; C A Davis; Janet Rossant
Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox.
Science (New York, N.Y.) 1991;251(4998):1239-43.
1991: C A Davis; D P Holmyard; K J Millen; Alexandra L Joyner
Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum.
Development (Cambridge, England) 1991;111(2):287-98.
1990: G R Martin; M Richman; S Reinsch; J H Nadeau; Alexandra L Joyner
Mapping of the two mouse engrailed-like genes: close linkage of En-1 to dominant hemimelia (Dh) on chromosome 1 and of En-2 to hemimelic extra-toes (Hx) on chromosome 5.
Genomics 1990;6(2):302-8.
1989: J Rossant; Alexandra L Joyner
Towards a molecular-genetic analysis of mammalian development.
Trends in genetics : TIG 1989;5(8):277-83.
1989: A Gossler; Alexandra L Joyner; Janet Rossant; W C Skarnes
Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes.
Science (New York, N.Y.) 1989;244(4903):463-5.
1989: C Logan; Alexandra L Joyner
PvuII and RsaI RFLPs for the human homeo box-containing gene EN2.
Nucleic acids research 1989;17(7):2879.
1989: C Logan; Alexandra L Joyner
An SstI RFLP for the human homeo box-containing gene EN2.
Nucleic acids research 1989;17(7):2878.
1989: C Logan; Alexandra L Joyner
An HaeIII RFLP for the human homeo box-containing gene EN1.
Nucleic acids research 1989;17(7):2877.
1989: Alexandra L Joyner; W C Skarnes; Janet Rossant
Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells.
Nature 1989;338(6211):153-6.
1989: C Logan; H F Willard; J M Rommens; Alexandra L Joyner
Chromosomal localization of the human homeo box-containing genes, EN1 and EN2.
Genomics 1989;4(2):206-9.
1988: C A Davis; Alexandra L Joyner
Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.
Genes & development 1988;2(12B):1736-44.
1988: C A Davis; S E Noble-Topham; Janet Rossant; Alexandra L Joyner
Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain.
Genes & development 1988;2(3):361-71.
1988: Gail R Martin; Alexandra L Joyner; L M Silver; H Lehrach; M Bucan
Analysis of a lethal mutation (tw18) in the mouse t-complex.
Progress in clinical and biological research 1988;284():147-61.
1987: Debra J Wolgemuth; C M Viviano; E Gizang-Ginsberg; M A Frohman; Alexandra L Joyner; G R Martin
Differential expression of the mouse homeobox-containing gene Hox-1.4 during male germ cell differentiation and embryonic development.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(16):5813-7.
1987: G R Martin; L M Silver; H S Fox; Alexandra L Joyner
Establishment of embryonic stem cell lines from preimplantation mouse embryos homozygous for lethal mutations in the t-complex.
Developmental biology 1987;121(1):20-8.
1987: Alexandra L Joyner; Gail R Martin
En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.
Genes & development 1987;1(1):29-38.
1985: C A Hauser; Alexandra L Joyner; R D Klein; T K Learned; G R Martin; Robert Tjian
Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.
Cell 1985;43(1):19-28.
1985: Alexandra L Joyner; Thomas B Kornberg; K G Coleman; D R Cox; G R Martin
Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene.
Cell 1985;43(1):29-37.
1985: Alexandra L Joyner; R V Lebo; Y W Kan; Robert Tjian; D R Cox; G R Martin
Comparative chromosome mapping of a conserved homoeo box region in mouse and human.
Nature 1985;314(6007):173-5.
1985: Alexandra L Joyner; C Hauser; T Kornberg; Robert Tjian; G Martin
Structure and expression of two classes of mammalian homeo-box-containing genes.
Cold Spring Harbor symposia on quantitative biology 1985;50():291-300.
1983: Alexandra L Joyner; A Bernstein
Retrovirus transduction: segregation of the viral transforming function and the herpes simplex virus tk gene in infectious Friend spleen focus-forming virus thymidine kinase vectors.
Molecular and cellular biology 1983;3(12):2191-202.
1983: Alexandra L Joyner; A Bernstein
Retrovirus transduction: generation of infectious retroviruses expressing dominant and selectable genes is associated with in vivo recombination and deletion events.
Molecular and cellular biology 1983;3(12):2180-90.
1983: J S Rubin; Alexandra L Joyner; A Bernstein; G F Whitmore
Molecular identification of a human DNA repair gene following DNA-mediated gene transfer.
Nature 1983;306(5939):206-8.
1983: Alexandra L Joyner; G Keller; R A Phillips; A Bernstein
Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells.
Nature 1983;305(5934):556-8.
1982: Alexandra L Joyner; Y Yamamoto; A Bernstein
Retrovirus long terminal repeats activate expression of coding sequences for the herpes simplex virus thymidine kinase gene.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(5):1573-7.
1981: Y Yamamoto; C L Gamble; S P Clark; Alexandra L Joyner; T Shibuya; M E MacDonald; D Mager; A Bernstein; T W Mak
Clonal analysis of early and late stages of erythroleukemia induced by molecular clones of integrated spleen focus-forming virus.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(11):6893-7.
1949: S M HARDY; Alexandra L Joyner; R W HOWARD
A report on the use of sodium pteroyl triglutamate in 413 cases.
New York state journal of medicine 1949;49(22):2697.