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Tongzhong Ju

Research Profile

Chemicals & Drugs

Phenomena

Glycosylation

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Living Beings

Mouse

Disorders

Glomerulonephritis, IGA

Anatomy

Physiology

Procedures

High Pressure Liquid Chromatography

Co-author Network

Publications

TOP 3
Rongjuan Mi; Lina Song; Irma van Die; Jianmei Wang; Yingchun Wang; Junwei Zeng; Rajindra P Aryal; Arlene B Chapman; Vanja K Crew; Richard D Cummings; Xiaokun Ding; Sylvain Lehoux; Tongzhong Ju
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing Tn antigen.
Rongjuan Mi; Lina Song; Irma van Die; Jianmei Wang; Yingchun Wang; Junwei Zeng; Rajindra P Aryal; Arlene B Chapman; Vanja K Crew; Richard D Cummings; Xiaokun Ding; Sylvain Lehoux; Tongzhong Ju
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen.
Yingchun Wang; David R Archer; Hyojung Choo; Xiaokun Ding; Shawn M Jobe; Tongzhong Ju; Rongjuan Mi; Richard D Cummings
Platelet biogenesis and functions require correct protein O-glycosylation.

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All Publications

2013: Rongjuan Mi; Lina Song; Irma van Die; Jianmei Wang; Yingchun Wang; Junwei Zeng; Rajindra P Aryal; Arlene B Chapman; Vanja K Crew; Richard D Cummings; Xiaokun Ding; Sylvain Lehoux; Tongzhong Ju
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing Tn antigen.
The Journal of biological chemistry 2013;288(16):11505.
2012: Rongjuan Mi; Lina Song; Irma van Die; Jianmei Wang; Yingchun Wang; Junwei Zeng; Rajindra P Aryal; Arlene B Chapman; Vanja K Crew; Richard D Cummings; Xiaokun Ding; Sylvain Lehoux; Tongzhong Ju
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen.
The Journal of biological chemistry 2012;287(49):41523-33.
2012: Yingchun Wang; David R Archer; Hyojung Choo; Xiaokun Ding; Shawn M Jobe; Tongzhong Ju; Rongjuan Mi; Richard D Cummings
Platelet biogenesis and functions require correct protein O-glycosylation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(40):16143-8.
2012: Andrew Borgert; Richard D Cummings; Jamie Heimburg-Molinaro; Tongzhong Ju; Yi Lasanajak; Mian Liu; Govind Ragupathi; David Smith; Xuezheng Song; Pamela Thompson; George Barany; David Live
Deciphering structural elements of mucin glycoprotein recognition.
ACS chemical biology 2012;7(6):1031-9.
2012: Rajindra P Aryal; Tongzhong Ju; Richard D Cummings
Tight complex formation between Cosmc chaperone and its specific client non-native T-synthase leads to enzyme activity and client-driven dissociation.
The Journal of biological chemistry 2012;287(19):15317-29.
2011: Qian Sun; Tongzhong Ju; Richard D Cummings
The transmembrane domain of the molecular chaperone Cosmc directs its localization to the endoplasmic reticulum.
The Journal of biological chemistry 2011;286(13):11529-42.
2011: Tongzhong Ju; Baoyun Xia; Rajindra P Aryal; Wenyi Wang; Yingchun Wang; Xiaokun Ding; Rongjuan Mi; Miao He; Richard D Cummings
A novel fluorescent assay for T-synthase activity.
Glycobiology 2011;21(3):352-62.
2011: Tongzhong Ju; Vivianne I Otto; Richard D Cummings
The Tn antigen-structural simplicity and biological complexity.
Angewandte Chemie (International ed. in English) 2011;50(8):1770-91.
2010: Wei Huang; Xinyu Zhang; Tongzhong Ju; Richard D Cummings; Lai-Xi Wang
Expeditious chemoenzymatic synthesis of CD52 glycopeptide antigens.
Organic & biomolecular chemistry 2010;8(22):5224-33.
2010: Jan G M Bolscher; Judith Brevoord; Kamran Nazmi; Tongzhong Ju; Enno C I Veerman; Joanna A E van Wijk; Richard D Cummings; Irma van Die
Solid-phase synthesis of a pentavalent GalNAc-containing glycopeptide (Tn antigen) representing the nephropathy-associated IgA hinge region.
Carbohydrate research 2010;345(14):1998-2003.
2010: Yingchun Wang; Tongzhong Ju; Xiaokun Ding; Baoyun Xia; Wenyi Wang; Lijun Xia; Miao He; Richard D Cummings
Cosmc is an essential chaperone for correct protein O-glycosylation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(20):9228-33.
2010: Sean R Stowell; Connie M Arthur; Marcelo Dias-Baruffi; Lilian C Rodrigues; JEAN-PHILIPPE GOURDINE; Jamie Heimburg-Molinaro; Tongzhong Ju; Ross J Molinaro; Carlos Rivera-Marrero; Baoyun Xia; David Smith; Richard D Cummings
Innate immune lectins kill bacteria expressing blood group antigen.
Nature medicine 2010;16(3):295-301.
2010: Rajindra P Aryal; Tongzhong Ju; Richard D Cummings
The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthase.
The Journal of biological chemistry 2010;285(4):2456-62.
2010: Tongzhong Ju; Richard D Cummings
Functional assays for the molecular chaperone cosmc.
Methods in enzymology 2010;479():107-22.
2009: Sean R Stowell; Sougata Karmakar; Connie M Arthur; Tongzhong Ju; Lilian C Rodrigues; Thalita B Riul; Marcelo Dias-Baruffi; Jonathan Miner; Rodger P McEver; Richard D Cummings
Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane.
Molecular biology of the cell 2009;20(5):1408-18.
2009: Cynthia Perrine; Tongzhong Ju; Richard D Cummings; Thomas A Gerken
Systematic determination of the peptide acceptor preferences for the human UDP-Gal:glycoprotein-alpha-GalNAc beta 3 galactosyltransferase (T-synthase).
Glycobiology 2009;19(3):321-8.
2008: Jianxin Fu; Holger Gerhardt; Karlien Hermans; Lacramioara Ivanciu; Tongzhong Ju; Xiaowei Liu; Florea Lupu; J Michael McDaniel; Samuel McGee; Annelii Ny; Emma Nye; Maria I Ramirez; Robert Silasi-Mansat; Baoyun Xia; Peter Carmeliet; Richard D Cummings; Lijun Xia
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.
The Journal of clinical investigation 2008;118(11):3725-37.
2008: Tongzhong Ju; Rajindra P Aryal; Caleb J Stowell; Richard D Cummings
Regulation of protein O-glycosylation by the endoplasmic reticulum-localized molecular chaperone Cosmc.
The Journal of cell biology 2008;182(3):531-42.
2008: Tongzhong Ju; Grainger S Lanneau; Tripti Gautam; Yingchun Wang; Baoyun Xia; Sean R Stowell; Margaret T Willard; Wenyi Wang; Jonathan Y Xia; Rosemary E Zuna; Zoltan Laszik; Doris M Benbrook; Marie H Hanigan; Richard D Cummings
Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc.
Cancer research 2008;68(6):1636-46.
2007: Guangyu An; Bo Wei; Baoyun Xia; J Michael McDaniel; Tongzhong Ju; Richard D Cummings; Jonathan Braun; Lijun Xia
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.
The Journal of experimental medicine 2007;204(6):1417-29.
2006: Tongzhong Ju; Qinlong Zheng; Richard D Cummings
Identification of core 1 O-glycan T-synthase from Caenorhabditis elegans.
Glycobiology 2006;16(10):947-58.
2005: Baoyun Xia; Ziad S Kawar; Tongzhong Ju; Richard A Alvarez; Goverdhan P Sachdev; Richard D Cummings
Versatile fluorescent derivatization of glycans for glycomic analysis.
Nature methods 2005;2(11):845-50.
2005: Tongzhong Ju; Richard D Cummings
Protein glycosylation: chaperone mutation in Tn syndrome.
Nature 2005;437(7063):1252.
2004: Lijun Xia; Tongzhong Ju; Andrew D Westmuckett; Guangyu An; Lacramioara Ivanciu; J Michael McDaniel; Florea Lupu; Richard D Cummings; Rodger P McEver
Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans.
The Journal of cell biology 2004;164(3):451-9.
2002: Tongzhong Ju; Richard D Cummings
A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16613-8.
2002: Tongzhong Ju; Kevin Brewer; Anil D'Souza; Richard D Cummings; William M Canfield
Cloning and expression of human core 1 beta1,3-galactosyltransferase.
The Journal of biological chemistry 2002;277(1):178-86.
2002: Tongzhong Ju; Richard D Cummings; William M Canfield
Purification, characterization, and subunit structure of rat core 1 Beta1,3-galactosyltransferase.
The Journal of biological chemistry 2002;277(1):169-77.
1999: Anne Leppänen; Padmaja Mehta; Ying-Bin Ouyang; Tongzhong Ju; Jari Helin; Kevin L Moore; Irma Van Die; William M Canfield; Rodger P McEver; Richard D Cummings
A novel glycosulfopeptide binds to P-selectin and inhibits leukocyte adhesion to P-selectin.
The Journal of biological chemistry 1999;274(35):24838-48.