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Ilkka Julkunen

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Mari Strengell; Thedi Ziegler; Veli-Jukka Anttila; Niina Ikonen; Anu Kantele; Ilkka Julkunen
Antibody responses against influenza A(H1N1)pdm09 virus after sequential vaccination with pandemic and seasonal influenza vaccines in Finnish healthcare professionals.
Pasi Kaukinen; Krister Melén; Laura Nousiainen; Maarit Sillanpää; Ilkka Julkunen
Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.
Minja Miettinen; Taija E Pietilä; Jaana Pirhonen; Pamela Osterlund; Matti Kankainen; Riina A Kekkonen; Riitta Korpela; Sinikka Latvala; Ilkka Julkunen
Nonpathogenic Lactobacillus rhamnosus activates the inflammasome and antiviral responses in human macrophages.

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2013: Mari Strengell; Thedi Ziegler; Veli-Jukka Anttila; Niina Ikonen; Anu Kantele; Ilkka Julkunen
Antibody responses against influenza A(H1N1)pdm09 virus after sequential vaccination with pandemic and seasonal influenza vaccines in Finnish healthcare professionals.
Influenza and other respiratory viruses 2013;7(3):431-8.
2013: Pasi Kaukinen; Krister Melén; Laura Nousiainen; Maarit Sillanpää; Ilkka Julkunen
Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.
Journal of medical virology 2013;85(1):71-82.
2012: Minja Miettinen; Taija E Pietilä; Jaana Pirhonen; Pamela Osterlund; Matti Kankainen; Riina A Kekkonen; Riitta Korpela; Sinikka Latvala; Ilkka Julkunen
Nonpathogenic Lactobacillus rhamnosus activates the inflammasome and antiviral responses in human macrophages.
Gut microbes 2012;3(6):510-22.
2012: Oxana V Denisova; Richard M Elliott; Lin Feng; Veijo Hukkanen; Ilkka Julkunen; Tero Ahola; Tero Aittokallio; Jef K De Brabander; Laura Kakkola; Hannimari Kallio-Kokko; Anu Kantele; Pasi Kaukinen; Suvi Kuivanen; Johanna Lampe; Ashwini Nagaraj; Henrik Paavilainen; Xavier Saelens; Jakob Stenman; Janne Tynell; Olli Vapalahti; Bhagwan Yadav; Denis E Kainov
Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.
The Journal of biological chemistry 2012;287(42):35324-32.
2012: Pamela Osterlund; Riku Fagerlund; Krister Melén; Minna M Poranen; L Peter Sarin; Mari Strengell; Ilkka Julkunen
Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry.
Journal of virology 2012;86(20):11183-93.
2012: Ilkka Julkunen; Mari Strengell; Niina Ikonen; Thedi Ziegler
[Influenza viruses--a challenge for vaccinations].
Duodecim; lääketieteellinen aikakauskirja 2012;128(18):1919-28.
2012: Krister Melén; Pascal Roussel; Janne Tynell; Riku Fagerlund; Danièle Hernandez-Verdun; Ilkka Julkunen
Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin.
Virology journal 2012;9():167.
2011: S Latvala; Minja Miettinen; R A Kekkonen; Riitta Korpela; Ilkka Julkunen
Lactobacillus rhamnosus GG and Streptococcus thermophilus induce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages.
Clinical and experimental immunology 2011;165(1):94-103.
2011: Niina Lietzén; Tiina Ohman; Johanna Rintahaka; Ilkka Julkunen; Tero Aittokallio; Sampsa Matikainen; Tuula A Nyman
Quantitative subcellular proteome and secretome profiling of influenza A virus-infected human primary macrophages.
PLoS pathogens 2011;7(5):e1001340.
2011: Esa Rönkkö; Niina Ikonen; Mia Kontio; Minna Haanpää; Hannimari Kallio-Kokko; Laura Mannonen; Maija Lappalainen; Ilkka Julkunen; Thedi Ziegler
Validation and diagnostic application of NS and HA gene-specific real-time reverse transcription-PCR assays for detection of 2009 pandemic influenza A (H1N1) viruses in clinical specimens.
Journal of clinical microbiology 2011;49(5):2009-11.
2011: Mari Strengell; Thedi Ziegler; Niina Ikonen; Ilkka Julkunen
Minor changes in the hemagglutinin of influenza A(H1N1)2009 virus alter its antigenic properties.
PloS one 2011;6(10):e25848.
2011: Sanna M Mäkelä; Pamela Osterlund; Ilkka Julkunen
TLR ligands induce synergistic interferon-β and interferon-λ1 gene expression in human monocyte-derived dendritic cells.
Molecular immunology 2011;48(4):505-15.
2010: Taija E Pietilä; Sinikka Latvala; Pamela Osterlund; Ilkka Julkunen
Inhibition of dynamin-dependent endocytosis interferes with type III IFN expression in bacteria-infected human monocyte-derived DCs.
Journal of leukocyte biology 2010;88(4):665-74.
2010: Pamela Osterlund; Jaana Pirhonen; Niina Ikonen; Esa Rönkkö; Mari Strengell; Sanna M Mäkelä; Mia Broman; Ole J Hamming; Rune Hartmann; Thedi Ziegler; Ilkka Julkunen
Pandemic H1N1 2009 influenza A virus induces weak cytokine responses in human macrophages and dendritic cells and is highly sensitive to the antiviral actions of interferons.
Journal of virology 2010;84(3):1414-22.
2010: Niina Ikonen; Minna Haanpää; Esa Rönkkö; Outi Lyytikäinen; Markku Kuusi; Petri Ruutu; Hannimari Kallio-Kokko; Laura Mannonen; Maija Lappalainen; Thedi Ziegler; Ilkka Julkunen
Genetic diversity of the 2009 pandemic influenza A(H1N1) viruses in Finland.
PloS one 2010;5(10):e13329.
2009: Susie S Mikkelsen; Søren B Jensen; Srikanth Chiliveru; Jesper Melchjorsen; Ilkka Julkunen; Matthias Gaestel; J Simon C Arthur; Richard A Flavell; Sankar Ghosh; Søren R Paludan
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
The Journal of biological chemistry 2009;284(16):10774-82.
2009: Sanna M Mäkelä; Mari Strengell; Taija E Pietilä; Pamela Osterlund; Ilkka Julkunen
Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.
Journal of leukocyte biology 2009;85(4):664-72.
2008: Minja Miettinen; Ville Veckman; Sinikka Latvala; Timo Sareneva; Sampsa Matikainen; Ilkka Julkunen
Live Lactobacillus rhamnosus and Streptococcus pyogenes differentially regulate Toll-like receptor (TLR) gene expression in human primary macrophages.
Journal of leukocyte biology 2008;84(4):1092-100.
2008: Nora Pöntynen; Mari Strengell; Niko Sillanpää; Juha Saharinen; Ismo Ulmanen; Ilkka Julkunen; Leena Peltonen
Critical immunological pathways are downregulated in APECED patient dendritic cells.
Journal of molecular medicine (Berlin, Germany) 2008;86(10):1139-52.
2008: Sinikka Latvala; Taija-E Pietila; Ville Veckman; Riina-A Kekkonen; Soile Tynkkynen; Riitta Korpela; Ilkka Julkunen
Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells.
World journal of gastroenterology : WJG 2008;14(36):5570-83; discussion 5581-2.
2008: Riku Fagerlund; Krister Melén; Xinmin Cao; Ilkka Julkunen
NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules.
Cellular signalling 2008;20(8):1442-51.
2008: Riina-A Kekkonen; Marko Sysi-Aho; Tuulikki Seppanen-Laakso; Ilkka Julkunen; Heikki Vapaatalo; Matej Oresic; Riitta Korpela
Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults.
World journal of gastroenterology : WJG 2008;14(20):3188-94.
2008: Riina-A Kekkonen; Netta Lummela; Heli Karjalainen; Sinikka Latvala; Soile Tynkkynen; Salme Jarvenpaa; Hannu Kautiainen; Ilkka Julkunen; Heikki Vapaatalo; Riitta Korpela
Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults.
World journal of gastroenterology : WJG 2008;14(13):2029-36.
2008: Päivi Ramu; Leandro Araujo Lobo; Maini Kukkonen; Eva Bjur; Marjo Suomalainen; Hanna Raukola; Minja Miettinen; Ilkka Julkunen; Otto Holst; Mikael Rhen; Timo K Korhonen; Kaarina Lähteenmäki
Activation of pro-matrix metalloproteinase-9 and degradation of gelatin by the surface protease PgtE of Salmonella enterica serovar Typhimurium.
International journal of medical microbiology : IJMM 2008;298(3-4):263-78.
2008: Leena S Heikkinen; Arunas Kazlauskas; Krister Melén; Ralf Wagner; Thedi Ziegler; Ilkka Julkunen; Kalle Saksela
Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.
The Journal of biological chemistry 2008;283(9):5719-27.
2008: Riina-A Kekkonen; Elina Kajasto; Minja Miettinen; Ville Veckman; Riitta Korpela; Ilkka Julkunen
Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-gamma production.
World journal of gastroenterology : WJG 2008;14(8):1192-203.
2008: Maarit Sillanpää; Pasi Kaukinen; Krister Melén; Ilkka Julkunen
Hepatitis C virus proteins interfere with the activation of chemokine gene promoters and downregulate chemokine gene expression.
The Journal of general virology 2008;89(Pt 2):432-43.
2008: Ville Veckman; Ilkka Julkunen
Streptococcus pyogenes activates human plasmacytoid and myeloid dendritic cells.
Journal of leukocyte biology 2008;83(2):296-304.
2007: Jaana Pirhonen; Jukka Sirén; Ilkka Julkunen; Sampsa Matikainen
IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages.
Journal of leukocyte biology 2007;82(5):1185-92.
2007: Pamela Osterlund; Taija E Pietilä; Ville Veckman; Sergei V Kotenko; Ilkka Julkunen
IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3434-42.
2007: Sari Jokinen; Pamela Osterlund; Ilkka Julkunen; Irja Davidkin
Cellular immunity to mumps virus in young adults 21 years after measles-mumps-rubella vaccination.
The Journal of infectious diseases 2007;196(6):861-7.
2007: Anne Lehtonen; Helena Ahlfors; Ville Veckman; Minja Miettinen; Riitta Lahesmaa; Ilkka Julkunen
Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells.
Journal of leukocyte biology 2007;82(3):710-20.
2007: Anna Kiialainen; Ville Veckman; Juha Saharinen; Juha Paloneva; Massimiliano Gentile; Panu Hakola; Dimitri Hemelsoet; Basil Ridha; Outi Kopra; Ilkka Julkunen; Leena Peltonen
Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response.
Journal of molecular medicine (Berlin, Germany) 2007;85(9):971-83.
2007: Riina A Kekkonen; Tommi Vasankari; Timo Vuorimaa; Tari Haahtela; Ilkka Julkunen; Riitta Korpela
The effect of probiotics on respiratory infections and gastrointestinal symptoms during training in marathon runners.
International journal of sport nutrition and exercise metabolism 2007;17(4):352-63.
2007: Krister Melén; Leena Kinnunen; Riku Fagerlund; Niina Ikonen; Karen Y Twu; Robert M Krug; Ilkka Julkunen
Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes.
Journal of virology 2007;81(11):5995-6006.
2007: Taija E Pietilä; Ville Veckman; Anne Lehtonen; Rongtuan Lin; John Hiscott; Ilkka Julkunen
Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):253-61.
2006: Minna M Koskenvuo; Markus Halminen; Miia Blomqvist; Raija Vainionpää; Jorma Ilonen; Ilkka Julkunen; Toivo T Salmi; Mika J Mäkelä
Expression of MxA protein in blood lymphocytes of children receiving anticancer chemotherapy.
Pediatric hematology and oncology 2006;23(8):649-60.
2006: Jukka Sirén; Tadaatsu Imaizumi; Devanand Sarkar; Taija E Pietilä; Diana L Noah; Rongtuan Lin; John Hiscott; Robert M Krug; Paul B Fisher; Ilkka Julkunen; Sampsa Matikainen
Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines.
Microbes and infection / Institut Pasteur 2006;8(8):2013-20.
2006: Heidi Berghäll; Jukka Sirén; Devanand Sarkar; Ilkka Julkunen; Paul B Fisher; Raija Vainionpää; Sampsa Matikainen
The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines.
Microbes and infection / Institut Pasteur 2006;8(8):2138-44.
2006: Mari Strengell; Anne Lehtonen; Sampsa Matikainen; Ilkka Julkunen
IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells.
Journal of leukocyte biology 2006;79(6):1279-85.
2006: Jesper Melchjorsen; Jukka Sirén; Ilkka Julkunen; Søren R Paludan; Sampsa Matikainen
Induction of cytokine expression by herpes simplex virus in human monocyte-derived macrophages and dendritic cells is dependent on virus replication and is counteracted by ICP27 targeting NF-kappaB and IRF-3.
The Journal of general virology 2006;87(Pt 5):1099-108.
2006: Sampsa Matikainen; Jukka Sirén; Jorma Tissari; Ville Veckman; Jaana Pirhonen; Martina Severa; Qiang Sun; Rongtuan Lin; Seppo Meri; Gilles Uzé; John Hiscott; Ilkka Julkunen
Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression.
Journal of virology 2006;80(7):3515-22.
2006: Anni Vainio; Riku Fagerlund; Krister Melén; Markus J Lehtinen; Ilkka Julkunen; Anni Virolainen
Serum antibodies to putative proteinase maturation protein A in children with acute otitis media.
Vaccine 2006;24(11):1792-9.
2006: Ville Veckman; Pamela Osterlund; Riku Fagerlund; Krister Melén; Sampsa Matikainen; Ilkka Julkunen
TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells.
Virology 2006;345(1):96-104.
2006: Pasi Kaukinen; Maarit Sillanpää; Sergei V Kotenko; Rongtuan Lin; John Hiscott; Krister Melén; Ilkka Julkunen
Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression.
Virology journal 2006;3():66.
2006: Tanja Ilmarinen; Krister Melén; Hannele Kangas; Ilkka Julkunen; Ismo Ulmanen; Petra Eskelin
The monopartite nuclear localization signal of autoimmune regulator mediates its nuclear import and interaction with multiple importin alpha molecules.
The FEBS journal 2006;273(2):315-24.
2005: Anne Lehtonen; Ville Veckman; Tuomas Nikula; Riitta Lahesmaa; Leena Kinnunen; Sampsa Matikainen; Ilkka Julkunen
Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6570-9.
2005: Thedi Ziegler; Sampsa Matikainen; Esa Rönkkö; Pamela Osterlund; Maarit Sillanpää; Jukka Sirén; Riku Fagerlund; Milla Immonen; Krister Melén; Ilkka Julkunen
Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells.
Journal of virology 2005;79(21):13800-5.
2005: Taija E Pietilä; Ville Veckman; Päivi Kyllönen; Kaarina Lähteenmäki; Timo K Korhonen; Ilkka Julkunen
Activation, cytokine production, and intracellular survival of bacteria in Salmonella-infected human monocyte-derived macrophages and dendritic cells.
Journal of leukocyte biology 2005;78(4):909-20.
2005: Pamela Osterlund; Ville Veckman; Jukka Sirén; Kevin M Klucher; John Hiscott; Sampsa Matikainen; Ilkka Julkunen
Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells.
Journal of virology 2005;79(15):9608-17.
2005: Riku Fagerlund; Leena Kinnunen; Matthias Köhler; Ilkka Julkunen; Krister Melén
NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4.
The Journal of biological chemistry 2005;280(16):15942-51.
2005: Jorma Tissari; Jukka Sirén; Seppo Meri; Ilkka Julkunen; Sampsa Matikainen
IFN-alpha enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4289-94.
2005: Jukka Sirén; Jaana Pirhonen; Ilkka Julkunen; Sampsa Matikainen
IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):1932-7.
2004: Jukka Sirén; Timo Sareneva; Jaana Pirhonen; Mari Strengell; Ville Veckman; Ilkka Julkunen; Sampsa Matikainen
Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages.
The Journal of general virology 2004;85(Pt 8):2357-64.
2004: Krister Melén; Riku Fagerlund; Maria Nyqvist; Päivi Keskinen; Ilkka Julkunen
Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs.
Journal of medical virology 2004;73(4):536-47.
2004: Mari Strengell; Ilkka Julkunen; Sampsa Matikainen
IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells.
Journal of leukocyte biology 2004;76(2):416-22.
2004: Ville Veckman; Minja Miettinen; Jaana Pirhonen; Jukka Sirén; Sampsa Matikainen; Ilkka Julkunen
Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells.
Journal of leukocyte biology 2004;75(5):764-71.
2004: Eliana M Coccia; Martina Severa; Elena Giacomini; Danièle Monneron; Maria Elena Remoli; Ilkka Julkunen; Marina Cella; Roberto Lande; Gilles Uzé
Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells.
European journal of immunology 2004;34(3):796-805.
2003: Anne Lehtonen; Riikka Lund; Riitta Lahesmaa; Ilkka Julkunen; Timo Sareneva; Sampsa Matikainen
IFN-alpha and IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4, and IRF-8 gene expression in human NK and T cells.
Cytokine 2003;24(3):81-90.
2003: Ville Veckman; Minja Miettinen; Sampsa Matikainen; Roberto Lande; Elena Giacomini; Eliana M Coccia; Ilkka Julkunen
Lactobacilli and streptococci induce inflammatory chemokine production in human macrophages that stimulates Th1 cell chemotaxis.
Journal of leukocyte biology 2003;74(3):395-402.
2003: Krister Melen; Riku Fagerlund; Jacqueline Franke; Matthias Kohler; Leena Kinnunen; Ilkka Julkunen
Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.
The Journal of biological chemistry 2003;278(30):28193-200.
2003: Mari Strengell; Sampsa Matikainen; Jukka Sirén; Anne Lehtonen; Don Foster; Ilkka Julkunen; Timo Sareneva
IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5464-9.
2003: Roberto Lande; Elena Giacomini; Tiziana Grassi; Maria Elena Remoli; Elisabetta Iona; Minja Miettinen; Ilkka Julkunen; Eliana M Coccia
IFN-alpha beta released by Mycobacterium tuberculosis-infected human dendritic cells induces the expression of CXCL10: selective recruitment of NK and activated T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1174-82.
2002: Jaana Pirhonen; Sampsa Matikainen; Ilkka Julkunen
Regulation of virus-induced IL-12 and IL-23 expression in human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5673-8.
2002: Mari Strengell; Timo Sareneva; Don Foster; Ilkka Julkunen; Sampsa Matikainen
IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3600-5.
2002: E Helin; Sampsa Matikainen; Ilkka Julkunen; Jyrki Heino; Timo Hyypiä; Raija Vainionpää
Measles virus enhances the expression of cellular immediate-early genes and DNA-binding of transcription factor AP-1 in lung epithelial A549 cells.
Archives of virology 2002;147(9):1721-32.
2002: Auli Paananen; Raimo Mikkola; Timo Sareneva; Sampsa Matikainen; M Hess; Magnus Andersson; Ilkka Julkunen; Mirja S Salkinoja-Salonen; Tuomo Timonen
Inhibition of human natural killer cell activity by cereulide, an emetic toxin from Bacillus cereus.
Clinical and experimental immunology 2002;129(3):420-8.
2002: Riku Fagerlund; Krister Mélen; Leena Kinnunen; Ilkka Julkunen
Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5.
The Journal of biological chemistry 2002;277(33):30072-8.
2002: Päivi Keskinen; Krister Melén; Ilkka Julkunen
Expression of HCV structural proteins impairs IFN-mediated antiviral response.
Virology 2002;299(2):164-71.
2002: Anna-Maija Vallittu; Markus Halminen; Jutta Peltoniemi; Jorma Ilonen; Ilkka Julkunen; Aimo A Salmi; Juha-Pekka Erälinna
Neutralizing antibodies reduce MxA protein induction in interferon-beta-1a-treated MS patients.
Neurology 2002;58(12):1786-90.
2002: Anne Lehtonen; Sampsa Matikainen; Minja Miettinen; Ilkka Julkunen
Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.
Journal of leukocyte biology 2002;71(3):511-9.
2001: E Helin; Raija Vainionpää; Timo Hyypiä; Ilkka Julkunen; Sampsa Matikainen
Measles virus activates NF-kappa B and STAT transcription factors and production of IFN-alpha/beta and IL-6 in the human lung epithelial cell line A549.
Virology 2001;290(1):1-10.
2001: Minja Miettinen; Timo Sareneva; Ilkka Julkunen; Sampsa Matikainen
IFNs activate toll-like receptor gene expression in viral infections.
Genes and immunity 2001;2(6):349-55.
2001: Sampsa Matikainen; Auli Paananen; Minja Miettinen; M Kurimoto; Tuomo Timonen; Ilkka Julkunen; Timo Sareneva
IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12.
European journal of immunology 2001;31(7):2236-45.
2001: Elena Giacomini; Elisabetta Iona; L Ferroni; M Miettinen; Lanfranco Fattorini; Graziella Orefici; Ilkka Julkunen; Eliana M Coccia
Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7033-41.
2001: Ilkka Julkunen; Timo Sareneva; Jaana Pirhonen; T Ronni; Krister Melén; Sampsa Matikainen
Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression.
Cytokine & growth factor reviews 2001;12(2-3):171-80.
2001: K Melen; Leena Kinnunen; Ilkka Julkunen
Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.
The Journal of biological chemistry 2001;276(19):16447-55.
2001: Jaana Pirhonen; Timo Sareneva; Ilkka Julkunen; Sampsa Matikainen
Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation.
European journal of immunology 2001;31(3):726-33.
2000: Ilkka Julkunen; Krister Melén; Maria Nyqvist; Jaana Pirhonen; Timo Sareneva; Sampsa Matikainen
Inflammatory responses in influenza A virus infection.
Vaccine 2000;19 Suppl 1():S32-7.
2000: Krister Melén; Päivi Keskinen; Anne Lehtonen; Ilkka Julkunen
Interferon-induced gene expression and signaling in human hepatoma cell lines.
Journal of hepatology 2000;33(5):764-72.
2000: Sampsa Matikainen; Jaana Pirhonen; Minja Miettinen; Anne Lehtonen; C Govenius-Vintola; Timo Sareneva; Ilkka Julkunen
Influenza A and sendai viruses induce differential chemokine gene expression and transcription factor activation in human macrophages.
Virology 2000;276(1):138-47.
2000: Timo Sareneva; Ilkka Julkunen; Sampsa Matikainen
IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1933-8.
2000: Minja Miettinen; Anne Lehtonen; Ilkka Julkunen; Sampsa Matikainen
Lactobacilli and Streptococci activate NF-kappa B and STAT signaling pathways in human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3733-40.
2000: Auli Paananen; Raimo Mikkola; Timo Sareneva; Sampsa Matikainen; Magnus Andersson; Ilkka Julkunen; Mirja S Salkinoja-Salonen; Tuomo Timonen
Inhibition of human NK cell function by valinomycin, a toxin from Streptomyces griseus in indoor air.
Infection and immunity 2000;68(1):165-9.
1999: Päivi Keskinen; Maria Nyqvist; Timo Sareneva; Jaana Pirhonen; Krister Melén; Ilkka Julkunen
Impaired antiviral response in human hepatoma cells.
Virology 1999;263(2):364-75.
1999: Mika J Mäkelä; Markus Halminen; Olli Ruuskanen; Tuomo Puhakka; Jaana Pirhonen; Ilkka Julkunen; Jorma Ilonen
Lack of induction by rhinoviruses of systemic type I interferon production or enhanced MxA protein expression during the common cold.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1999;18(9):665-8.
1999: Riitta Räty; Marjaana Kleemola; Krister Melén; Mirja Stenvik; Ilkka Julkunen
Efficacy of PCR and other diagnostic methods for the detection of respiratory adenoviral infections.
Journal of medical virology 1999;59(1):66-72.
1999: Jaana Pirhonen; Timo Sareneva; M Kurimoto; Ilkka Julkunen; Sampsa Matikainen
Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7322-9.
1999: Sampsa Matikainen; Timo Sareneva; T Ronni; Anne Lehtonen; Päivi J Koskinen; Ilkka Julkunen
Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells.
Blood 1999;93(6):1980-91.
1998: Minja Miettinen; Sampsa Matikainen; J Vuopio-Varkila; Jaana Pirhonen; K Varkila; M Kurimoto; Ilkka Julkunen
Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18, and gamma interferon production in human peripheral blood mononuclear cells.
Infection and immunity 1998;66(12):6058-62.
1998: T Ronni; Sampsa Matikainen; Anne Lehtonen; J Palvimo; J Dellis; F Van Eylen; J F Goetschy; M Horisberger; J Content; Ilkka Julkunen
The proximal interferon-stimulated response elements are essential for interferon responsiveness: a promoter analysis of the antiviral MxA gene.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(9):773-81.
1998: Tiina Paunio; Hannele Kangas; Outi Kopra; M H Buc-Caron; jean-jacques robert; S Kaasinen; Ilkka Julkunen; J Mallet; Leena Peltonen
Cells of the neuronal lineage play a major role in the generation of amyloid precursor fragments in gelsolin-related amyloidosis.
The Journal of biological chemistry 1998;273(26):16319-24.
1998: Timo Sareneva; Sampsa Matikainen; M Kurimoto; Ilkka Julkunen
Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):6032-8.
1998: Sampsa Matikainen; Anne Lehtonen; Timo Sareneva; Ilkka Julkunen
Regulation of IRF and STAT gene expression by retinoic acid.
Leukemia & lymphoma 1998;30(1-2):63-71.
1998: Timo Sareneva; Sampsa Matikainen; J Vanhatalo; Krister Melén; J Pelkonen; Ilkka Julkunen
Kinetics of cytokine and NFAT gene expression in human interleukin-2-dependent T lymphoblasts stimulated via T-cell receptor.
Immunology 1998;93(3):350-7.
1997: Krister Melén; Ilkka Julkunen
Nuclear cotransport mechanism of cytoplasmic human MxB protein.
The Journal of biological chemistry 1997;272(51):32353-9.
1997: Anne Lehtonen; Sampsa Matikainen; Ilkka Julkunen
Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):794-803.
1997: Päivi Keskinen; T Ronni; Sampsa Matikainen; Anne Lehtonen; Ilkka Julkunen
Regulation of HLA class I and II expression by interferons and influenza A virus in human peripheral blood mononuclear cells.
Immunology 1997;91(3):421-9.
1997: Sampsa Matikainen; T Ronni; Anne Lehtonen; Timo Sareneva; Krister Melén; S Nordling; D E Levy; Ilkka Julkunen
Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(6):687-98.
1997: Markus Halminen; Jorma Ilonen; Ilkka Julkunen; Olli Ruuskanen; Olli Simell; Mika J Mäkelä
Expression of MxA protein in blood lymphocytes discriminates between viral and bacterial infections in febrile children.
Pediatric research 1997;41(5):647-50.
1997: T Ronni; Sampsa Matikainen; Timo Sareneva; Krister Melén; Jaana Pirhonen; Päivi Keskinen; Ilkka Julkunen
Regulation of IFN-alpha/beta, MxA, 2',5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2363-74.
1996: Timo Sareneva; E Mørtz; H Tölö; Peter Roepstorff; Ilkka Julkunen
Biosynthesis and N-glycosylation of human interferon-gamma. Asn25 and Asn97 differ markedly in how efficiently they are glycosylated and in their oligosaccharide composition.
European journal of biochemistry / FEBS 1996;242(2):191-200.
1996: E Mørtz; Timo Sareneva; Ilkka Julkunen; Peter Roepstorff
Does matrix-assisted laser desorption/ionization mass spectrometry allow analysis of carbohydrate heterogeneity in glycoproteins? A study of natural human interferon-gamma.
Journal of mass spectrometry : JMS 1996;31(10):1109-18.
1996: M Kanerva; Krister Melén; Antti Vaheri; Ilkka Julkunen
Inhibition of puumala and tula hantaviruses in Vero cells by MxA protein.
Virology 1996;224(1):55-62.
1996: Krister Melén; Päivi Keskinen; T Ronni; Timo Sareneva; K Lounatmaa; Ilkka Julkunen
Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope.
The Journal of biological chemistry 1996;271(38):23478-86.
1996: A Riikonen; Juha Rouvinen; R Tikkanen; Ilkka Julkunen; Leena Peltonen; Anu Jalanko
Primary folding of aspartylglucosaminidase. Significance of disulfide bridges and evidence of early multimerization.
The Journal of biological chemistry 1996;271(35):21340-4.
1996: Sampsa Matikainen; T Ronni; M Hurme; R Pine; Ilkka Julkunen
Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells.
Blood 1996;88(1):114-23.
1996: E Mørtz; Timo Sareneva; S Haebel; Ilkka Julkunen; Peter Roepstorff
Mass spectrometric characterization of glycosylated interferon-gamma variants separated by gel electrophoresis.
Electrophoresis 1996;17(5):925-31.
1996: Olli Vapalahti; Ake Lundkvist; Hannimari Kallio-Kokko; K Paukku; Ilkka Julkunen; Hilkka Lankinen; Antti Vaheri
Antigenic properties and diagnostic potential of puumala virus nucleocapsid protein expressed in insect cells.
Journal of clinical microbiology 1996;34(1):119-25.
1995: Olli Vapalahti; Hannimari Kallio-Kokko; Ale Närvänen; Ilkka Julkunen; Ake Lundkvist; Alexander Plyusnin; H Lehväslaiho; Markus Brummer-Korvenkontio; Antti Vaheri; Hilkka Lankinen
Human B-cell epitopes of Puumala virus nucleocapsid protein, the major antigen in early serological response.
Journal of medical virology 1995;46(4):293-303.
1995: Timo Sareneva; Jaana Pirhonen; K Cantell; Ilkka Julkunen
N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance.
The Biochemical journal 1995;308 ( Pt 1)():9-14.
1995: T Lotta; J Vidgren; Carola Gabriella Tilgmann; Ismo Ulmanen; Krister Melén; Ilkka Julkunen; Jyrki Taskinen
Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme.
Biochemistry 1995;34(13):4202-10.
1995: T Ronni; Timo Sareneva; Jaana Pirhonen; Ilkka Julkunen
Activation of IFN-alpha, IFN-gamma, MxA, and IFN regulatory factor 1 genes in influenza A virus-infected human peripheral blood mononuclear cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2764-74.
1995: M Temonen; Hilkka Lankinen; Olli Vapalahti; T Ronni; Ilkka Julkunen; Antti Vaheri
Effect of interferon-alpha and cell differentiation on Puumala virus infection in human monocyte/macrophages.
Virology 1995;206(1):8-15.
1994: Krister Melén; Ilkka Julkunen
Mutational analysis of murine Mx1 protein: GTP binding core domain is essential for anti-influenza A activity.
Virology 1994;205(1):269-79.
1994: Timo Sareneva; Jaana Pirhonen; K Cantell; Nisse Kalkkinen; Ilkka Julkunen
Role of N-glycosylation in the synthesis, dimerization and secretion of human interferon-gamma.
The Biochemical journal 1994;303 ( Pt 3)():831-40.
1994: T Karhunen; Carola Gabriella Tilgmann; Ismo Ulmanen; Ilkka Julkunen; Pertti Panula
Distribution of catechol-O-methyltransferase enzyme in rat tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(8):1079-90.
1994: Krister Melén; T Ronni; T Lotta; Ilkka Julkunen
Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins.
The Journal of biological chemistry 1994;269(3):2009-15.
1993: Timo Sareneva; K Cantell; L Pyhälä; Jaana Pirhonen; Ilkka Julkunen
Effect of carbohydrates on the pharmacokinetics of human interferon-gamma.
Journal of interferon research 1993;13(4):267-9.
1993: T Ronni; Krister Melén; A Malygin; Ilkka Julkunen
Control of IFN-inducible MxA gene expression in human cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(5):1715-26.
1993: E Ikonen; Ilkka Julkunen; O K Tollersrud; N Kalkkinen; Leena Peltonen
Lysosomal aspartylglucosaminidase is processed to the active subunit complex in the endoplasmic reticulum.
The EMBO journal 1993;12(1):295-302.
1992: Krister Melén; T Ronni; B Broni; R M Krug; C H von Bonsdorff; Ilkka Julkunen
Interferon-induced Mx proteins form oligomers and contain a putative leucine zipper.
The Journal of biological chemistry 1992;267(36):25898-907.
1992: Carola Gabriella Tilgmann; K Melen; K Lundström; Anu Jalanko; Ilkka Julkunen; Nisse Kalkkinen; Ismo Ulmanen
Expression of recombinant soluble and membrane-bound catechol O-methyltransferase in eukaryotic cells and identification of the respective enzymes in rat brain.
European journal of biochemistry / FEBS 1992;207(2):813-21.
1992: Erkki Raulo; Ilkka Julkunen; J Merenmies; R Pihlaskari; Heikki Rauvala
Secretion and biological activities of heparin-binding growth-associated molecule. Neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein.
The Journal of biological chemistry 1992;267(16):11408-16.
1992: K Cantell; S Hirvonen; Timo Sareneva; Jaana Pirhonen; Ilkka Julkunen
Differential inactivation of interferons by a protease from human granulocytes.
Journal of interferon research 1992;12(3):177-83.
1990: B Broni; Ilkka Julkunen; Jon H Condra; Mary-Ellen Davies; M J Berry; Robert M Krug
Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein.
Journal of virology 1990;64(12):6335-40.