Daniel Jun

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Karasova Jana Zdarova; Bajgar Jiri; Jun Daniel; Pavlikova Ruzena; Kuca Kamil
Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX.
Soukup Ondrej; Proska Jan; Binder Jiri; Karasova Jana Zdarova; Tobin Gunnar; Jun Daniel; Marek Jan; Musílek Kamil; Fusek Josef; Kuca Kamil
Methylacridinium and its cholinergic properties.
Kuca Kamil; Cabal Jiri; Jung Yung Sik; Musilek Kamil; Soukup Ondrej; Jun Daniel; Pohanka Miroslav; Musilova Lucie; Karasová Jana; Novotný Ladislav; Hrabinova Martina
Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127.

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2009: Karasova Jana Zdarova; Bajgar Jiri; Jun Daniel; Pavlikova Ruzena; Kuca Kamil
Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX.
Neurotoxicity research 2009;16(4):356-60.
2009: Soukup Ondrej; Proska Jan; Binder Jiri; Karasova Jana Zdarova; Tobin Gunnar; Jun Daniel; Marek Jan; Musílek Kamil; Fusek Josef; Kuca Kamil
Methylacridinium and its cholinergic properties.
Neurotoxicity research 2009;16(4):372-7.
2009: Kuca Kamil; Cabal Jiri; Jung Yung Sik; Musilek Kamil; Soukup Ondrej; Jun Daniel; Pohanka Miroslav; Musilova Lucie; Karasová Jana; Novotný Ladislav; Hrabinova Martina
Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127.
Basic & clinical pharmacology & toxicology 2009;105(3):207-10.
2009: Bajgar Jiri; Fusek Josef; Kassa Jiri; Kuca Kamil; Jun Daniel
Chemical aspects of pharmacological prophylaxis against nerve agent poisoning.
Current medicinal chemistry 2009;16(23):2977-86.
2008: Soukup Ondrej; Pohanka Miroslav; Tobin Gunnar; Jun Daniel; Fusek Josef; Musilek Kamil; Marek Jan; Kassa Jiri; Kuca Kamil
The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder.
Neuro endocrinology letters 2008;29(5):759-62.
2008: Pohanka Miroslav; Jun Daniel; Kuca Kamil
Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators.
Talanta 2008;77(1):451-4.
2008: Musilek Kamil; Kucera Jiri; Jun Daniel; Dohnal Vlastimil; Opletalova Veronika; Kuca Kamil
Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry 2008;16(17):8218-23.
2008: Jun D; Musilova L; Kuca K; Kassa J; Bajgar J
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.
Chemico-biological interactions 2008;175(1-3):421-4.
2008: Bajgar Jiri; Fusek Josef; Kassa Jiri; Jun Daniel; Kuca Kamil; Hajek Petr
An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents.
Chemico-biological interactions 2008;175(1-3):281-5.
2008: Kassa Jiri; Jun Daniel; Karasova Jana; Bajgar Jiri; Kuca Kamil
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats.
Chemico-biological interactions 2008;175(1-3):425-7.
2008: Pejchal Jaroslav; Osterreicher Jan; Kuca Kamil; Jun Daniel; Bajgar Jiri; Kassa Jiri
The influence of acetylcholinesterase reactivators on selected hepatic functions in rats.
Basic & clinical pharmacology & toxicology 2008;103(2):119-23.
2008: Cervenka Frantisek; Koleckar Vit; Rehakova Zuzana; Jahodar Ludek; Kunes Jiri; Opletal Lubomir; Hyspler Radomir; Jun Daniel; Kuca Kamil
Evaluation of natural substances from Evolvulus alsinoides L. with the purpose of determining their antioxidant potency.
Journal of enzyme inhibition and medicinal chemistry 2008;23(4):574-8.
2008: Koleckar Vit; Kubikova Katerina; Rehakova Zuzana; Kuca Kamil; Jun Daniel; Jahodar Ludek; Opletal Lubomir
Condensed and hydrolysable tannins as antioxidants influencing the health.
Mini reviews in medicinal chemistry 2008;8(5):436-47.
2008: Patocka Jiri; Jun Daniel; Kuca Kamil
Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease.
Current drug metabolism 2008;9(4):332-5.
2008: Musilek Kamil; Jampilek Josef; Dohnal Jiri; Jun Daniel; Gunn-Moore Frank; Dolezal Martin; Kuca Kamil
RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker.
Analytical and bioanalytical chemistry 2008;391(1):367-72.
2008: Jun Daniel; Stodulka Petr; Kuca Kamil; Koleckar Vit; Dolezal Bohuslav; Simon Peter; Veverka Miroslav
TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate.
Journal of chromatographic science 2008;46(4):316-9.
2008: Koleckar Vit; Opletal Lubomir; Brojerova Eliska; Rehakova Zuzana; Cervenka Frantisek; Kubikova Katerina; Kuca Kamil; Jun Daniel; Polasek Miroslav; Kunes Jiri; Jahodar Ludek
Evaluation of natural antioxidants of Leuzea carthamoides as a result of a screening study of 88 plant extracts from the European Asteraceae and Cichoriaceae.
Journal of enzyme inhibition and medicinal chemistry 2008;23(2):218-24.
2008: Stodulka Petr; Koleckar Vit; Jun Daniel; Kuca Kamil; Rehakova Zuzana; Kubikova Katerina; Jahodar Ludek; Kunes Jiri; Opletal Lubomir
High-performance liquid chromatography analysis of four Leuzea carthamoides flavonoids.
Journal of chromatographic science 2008;46(2):162-4.
2008: Musilek Kamil; Holas Ondrej; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Opletalova Veronika; Dolezal Martin
Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2008;23(1):70-6.
2008: Dohnal Vlastimil; Jezkova Alena; Jun Daniel; Kuca Kamil
Metabolic pathways of T-2 toxin.
Current drug metabolism 2008;9(1):77-82.
2008: Pohanka Miroslav; Jun Daniel; Kalasz Huba; Kuca Kamil
Cholinesterase biosensor construction - a review.
Protein and peptide letters 2008;15(8):795-8.
2008: Koleckar Vit; Brojerova Eliska; Rehakova Zuzana; Kubikova Katerina; Cervenka Frantisek; Kuca Kamil; Jun Daniel; Hronek Miloslav; Opletalova Veronika; Opletal Lubomir
In vitro antiplatelet activity of flavonoids from Leuzea carthamoides.
Drug and chemical toxicology 2008;31(1):27-35.
2008: Jun Daniel; Kuca Kamil; Picha Jan; Koleckar Vit; Marek Jan
Potency of novel oximes to reactivate sarin inhibited human cholinesterases.
Drug and chemical toxicology 2008;31(1):1-9.
2007: Bajgar J; Kuca K; Jun D; Bartosova L; Fusek J
Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents.
Current drug metabolism 2007;8(8):803-9.
2007: Musilek Kamil; Jun Daniel; Cabal Jiri; Kassa Jiri; Gunn-Moore Frank; Kuca Kamil
Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).
Journal of medicinal chemistry 2007;50(22):5514-8.
2007: Kassa Jiri; Jun Daniel; Kuca Kamil; Bajgar Jiri
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats.
Basic & clinical pharmacology & toxicology 2007;101(5):328-32.
2007: Musilek Kamil; Holas Ondrej; Jun Daniel; Dohnal Vlastimil; Gunn-Moore Frank; Opletalova Veronika; Dolezal Martin; Kuca Kamil
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry 2007;15(21):6733-41.
2007: Bajgar J; Kuca K; Fusek J; Karasova J; Kassa J; Cabal J; Jun D; Blaha V
Inhibition of blood cholinesterases following intoxication with VX and its derivatives.
Journal of applied toxicology : JAT 2007;27(5):458-63.
2007: Musilek Kamil; Holas Ondrej; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Dolezal Martin
Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):425-32.
2007: Dohnal V; Jezková A; Kuca K; Jun D
[T-2 toxin: occurrence and detection]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2007;56(4):174-7.
2007: Kuca Kamil; Jun Daniel; Cabal Jiri; Musilova Lucie
Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases: an in vitro study.
Basic & clinical pharmacology & toxicology 2007;101(1):25-8.
2007: Kassa Jiri; Jun Daniel; Kuca Kamil
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats.
Journal of enzyme inhibition and medicinal chemistry 2007;22(3):297-300.
2007: Kuca Kamil; Cabal Jiri; Jun Daniel; Hrabinova Martina
Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin.
Clinical toxicology (Philadelphia, Pa.) 2007;45(5):512-5.
2007: Musilek Kamil; Holas Ondrej; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Opletalova Veronika; Dolezal Martin
Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2007;17(11):3172-6.
2007: Bajgar Jiri; Fusek Josef; Kuca Kamil; Bartosova Lucie; Jun Daniel
Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction.
Mini reviews in medicinal chemistry 2007;7(5):461-6.
2007: Koleckár V; Brojerová E; Opletal L; Jun D; Kuca K
[Antioxidants, free radicals, mechanism of action and application in the therapy of the sulfur mustard caused injury]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2007;56(2):73-6.
2007: Kuca Kamil; Cabal Jiri; Jun Daniel; Musilek Kamil
In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases.
Neurotoxicity research 2007;11(2):101-6.
2007: Bajgar Jiri; Hajek Petr; Slizova Dasa; Krs Otakar; Fusek Josef; Kuca Kamil; Jun Daniel; Bartosova Lucie; Blaha Vaclav
Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study.
Chemico-biological interactions 2007;165(1):14-21.
2007: Musílek Kamil; Kuca Kamil; Jun Daniel
Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX).
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2007;50(3):203-6.
2007: Kuca Kamil; Jun Daniel; Bajgar Jiri
Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications.
Current pharmaceutical design 2007;13(33):3445-52.
2007: Kuca Kamil; Marek Jan; Stodulka Petr; Musilek Kamil; Hanusova Petra; Hrabinova Martina; Jun Daniel
Preparation of benzalkonium salts differing in the length of a side alkyl chain.
Molecules (Basel, Switzerland) 2007;12(10):2341-7.
2007: Kuca Kamil; Musilek Kamil; Paar Martin; Jun Daniel; Stodulka Petr; Hrabinova Martina; Marek Jan
Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator.
Molecules (Basel, Switzerland) 2007;12(8):1964-72.
2007: Musilek Kamil; Kuca Kamil; Dohnal Vlastimil; Jun Daniel; Marek Jan; Koleckar Vit
Two step synthesis of a non-symmetric acetylcholinesterase reactivator.
Molecules (Basel, Switzerland) 2007;12(8):1755-61.
2007: Bajgar Jiri; Bartosova Lucie; Kuca Kamil; Jun Daniel; Fusek Josef
Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase.
Drug and chemical toxicology 2007;30(4):351-9.
2007: Kuca Kamil; Jun Daniel; Bajgar Jiri
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Drug and chemical toxicology 2007;30(1):31-40.
2006: Bajgar Jiri; Bartosova Lucie; Fusek Josef; Jun Daniel; Kuca Kamil
Equine butyrylcholinesterase protects rats against inhalation exposure to sublethal sarin concentrations.
Arhiv za higijenu rada i toksikologiju 2006;57(4):391-5.
2006: Racakova Veronika; Hrabinova Martina; Jun Daniel; Kuca Kamil
Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase.
Arhiv za higijenu rada i toksikologiju 2006;57(4):387-90.
2006: Kuca Kamil; Cabal Jiri; Jun Daniel; Bajgar Jiri; Hrabinova Martina
Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases.
Journal of enzyme inhibition and medicinal chemistry 2006;21(6):663-6.
2006: Musilek Kamil; Holas Ondrej; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Dolezal Martin
Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2006;16(21):5673-6.
2006: Hrabinova Martina; Musilek Kamil; Jun Daniel; Kuca Kamil
New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin.
Journal of enzyme inhibition and medicinal chemistry 2006;21(5):515-9.
2006: Kassa Jiri; Jun Daniel; Kuca Kamil
The reactivating and therapeutic efficacy of oximes to counteract Russian VX poisonings.
International journal of toxicology 2006;25(5):397-401.
2006: Bajgar J; Fusek J; Bartosova L; Jun D; Kuca K
Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents.
Journal of applied toxicology : JAT 2006;26(5):439-43.
2006: Kuca Kamil; Cabal Jiri; Kassa Jiri; Jun Daniel; Hrabinova Martina
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
Journal of toxicology and environmental health. Part A 2006;69(15):1431-40.
2006: Bartosova Lucie; Kuca Kamil; Kunesova Gabriela; Jun Daniel
The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure.
Neurotoxicity research 2006;9(4):291-6.
2006: Musílek K; Kuca K; Jun D; Dohnal V; Kim T H; Jung Y S; Dolezal M
[Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2006;55(3):115-9.
2006: Jun Daniel; Kuca Kamil; Hronek Miloslav; Opletal Lubomir
Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro.
Journal of applied toxicology : JAT 2006;26(3):258-61.
2006: Kuca Kamil; Jun Daniel; Cabal Jiri; Hrabinova Martina; Bartosova Lucie; Opletalova Veronika
Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent.
Basic & clinical pharmacology & toxicology 2006;98(4):389-94.
2006: Musilek Kamil; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Dolezal Martin
Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2006;16(3):622-7.
2006: Kuca Kamil; Cabal Jiri; Jun Daniel; Hrabinova Martina
In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings.
Drug and chemical toxicology 2006;29(4):443-9.
2005: Kuca Kamil; Cabal Jirí; Jun Daniel; Kassa Jirí; Bartosová Lucie; Kunesová Gabriela; Dohnal Vlastimil
Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):429-31.
2005: Dohnal Vlastimil; Kuca Kamil; Jun Daniel
What are artificial neural networks and what they can do?
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):221-4.
2005: Jun Daniel; Kuca Kamil; Cabal Jiri; Bartosova Lucie; Kunesova Gabriela; Kassa Jiri
Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species.
Chemico-biological interactions 2005;157-158():385-7.
2005: Kuca Kamil; Bartosova Lucie; Kassa Jiri; Cabal Jiri; Bajgar Jiri; Kunesova Gabriela; Jun Daniel
Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo.
Chemico-biological interactions 2005;157-158():367-8.
2005: Bartosova Lucie; Kuca Kamil; Jun Daniel; Kunesova Gabriela
Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing.
International journal of toxicology 2005;24(6):399-402.
2005: Kuca Kamil; Cabal Jiri; Musilek Kamil; Jun Daniel; Bajgar Jiri
Effective bisquaternary reactivators of tabun-inhibited AChE.
Journal of applied toxicology : JAT 2005;25(6):491-5.
2005: Musilek K; Kuca K; Jun D; Dohnal V; Dolezal M
Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2005;20(5):409-15.
2005: Cabal J; Kuca K; Jun D; Bajgar J; Hrabinová M
[A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2005;54(4):192-5.
2005: Dohnal V; Kuca K; Jun D
[Methods of artificial intelligence: a new trend in pharmacy]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2005;54(4):163-7.
2005: Kuca Kamil; Cabal Jiri; Jun Daniel; Kassa Jiri; Bartosová Lucie; Kunesová Gabriela
In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions.
Journal of applied toxicology : JAT 2005;25(4):296-300.
2005: Kuca Kamil; Cabal Jiri; Kassa Jiri; Jun Daniel; Hrabinová Martina
Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain.
Journal of applied toxicology : JAT 2005;25(4):271-6.
2005: Kuca Kamil; Bartosová Lucie; Jun Daniel; Patocka Jirí; Cabal Jirí; Kassa Jirí; Kunesová Gabriela
New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(1):75-82.
2005: Kuca Kamil; Cabal Jirí; Kassa Jirí; Jun Daniel; Hrabinová Martina
A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2005;48(2):81-6.
2004: Patocka Jirí; Kuca Kamil; Jun Daniel
Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2004;47(4):215-28.
2004: Kuca Kamil; Patocka Jirí; Cabal Jirí; Jun Daniel
Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes.
Neurotoxicity research 2004;6(7-8):565-70.
2003: Opletalová V; Jahodár L; Jun D; Opletal L
[Chalcones (1,3-diarylpropen-1-ones) and their analogs as potential therapeutic agents in cardiovascular system diseases]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2003;52(1):12-9.

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