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Manuel Baca

Research Profile

Chemicals & Drugs

Concepts & Ideas

Physiology

Living Beings

Mouse

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Nicholas T Redpath; William R Strohl; Nicholas J Wilson; Andrea Woods; Yibin Xu; Dennis M Zaller; Jian-Guo Zhang; Zhiqiang An; AE Andrews; Manuel Baca; Hal Braley; Peter E Czabotar; Robin E Ernst; Louis J Fabri; Gail Forrest; Thomas P J Garrett; Douglas J Hilton; Cheryl Ireland; Ping Lu; Cindy S Luo; Andrew D Nash; Nicos A Nicola
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1.
Christine A White; Jian-Guo Zhang; Lois salamonsen; Manuel Baca; W Douglas Fairlie; Donald Metcalf; Nicos A Nicola; Lorraine Robb; Evdokia Dimitriadis
Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy.
jeffrey babon; Edward J McManus; Shenggen Yao; David P DeSouza; Lisa A Mielke; Naomi S Sprigg; Tracy A Willson; Douglas J Hilton; Nicos A Nicola; Manuel Baca; Sandra E Nicholson; Raymond S Norton
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

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All Publications

2013: Nicholas T Redpath; William R Strohl; Nicholas J Wilson; Andrea Woods; Yibin Xu; Dennis M Zaller; Jian-Guo Zhang; Zhiqiang An; AE Andrews; Manuel Baca; Hal Braley; Peter E Czabotar; Robin E Ernst; Louis J Fabri; Gail Forrest; Thomas P J Garrett; Douglas J Hilton; Cheryl Ireland; Ping Lu; Cindy S Luo; Andrew D Nash; Nicos A Nicola
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1.
The Biochemical journal 2013;451(2):165-75.
2007: Christine A White; Jian-Guo Zhang; Lois salamonsen; Manuel Baca; W Douglas Fairlie; Donald Metcalf; Nicos A Nicola; Lorraine Robb; Evdokia Dimitriadis
Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19357-62.
2006: jeffrey babon; Edward J McManus; Shenggen Yao; David P DeSouza; Lisa A Mielke; Naomi S Sprigg; Tracy A Willson; Douglas J Hilton; Nicos A Nicola; Manuel Baca; Sandra E Nicholson; Raymond S Norton
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.
Molecular cell 2006;22(2):205-16.
2006: Andrew D Nash; Manuel Baca; Christine Wright; Pierre D Scotney
The biology of vascular endothelial growth factor-B (VEGF-B).
Pulmonary pharmacology & therapeutics 2006;19(1):61-9.
2005: jeffrey babon; Shenggen Yao; David P DeSouza; Christopher F Harrison; Louis J Fabri; Edvards Liepinsh; Sergio D Scrofani; Manuel Baca; Raymond S Norton
Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain.
The FEBS journal 2005;272(23):6120-30.
2005: Evdokia Dimitriadis; Chelsea Stoikos; Manuel Baca; W Douglas Fairlie; J E McCoubrie; Lois salamonsen
Relaxin and prostaglandin E(2) regulate interleukin 11 during human endometrial stromal cell decidualization.
The Journal of clinical endocrinology and metabolism 2005;90(6):3458-65.
2004: Ian Gentle; David P De Souza; Manuel Baca
Direct production of proteins with N-terminal cysteine for site-specific conjugation.
Bioconjugate chemistry 2004;15(3):658-63.
2004: W Douglas Fairlie; Alessandro D Uboldi; Joanne E McCoubrie; Chunxiao C Wang; Erinna Lee; Shenggen Yao; David P De Souza; Sandra Mifsud; Donald Metcalf; Nicos A Nicola; Raymond S Norton; Manuel Baca
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.
The Journal of biological chemistry 2004;279(3):2125-34.
2004: Manuel Baca
Analysis of SH2 ligands and identification of sites of interaction.
Methods in molecular biology (Clifton, N.J.) 2004;249():111-20.
2003: W Douglas Fairlie; Alessandro D Uboldi; George J Hemmings; Brian J Smith; Helene M Martin; Phillip O Morgan; Manuel Baca
A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).
Biochemistry 2003;42(45):13193-201.
2003: W Douglas Fairlie; David P De Souza; Nicos A Nicola; Manuel Baca
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.
The Biochemical journal 2003;372(Pt 2):495-502.
2002: Christopher J Greenhalgh; Donald Metcalf; Anne L Thaus; Jason E Corbin; Rachel Uren; Phillip O Morgan; Louis J Fabri; Jian-Guo Zhang; Helene M Martin; Tracy A Willson; Nils Billestrup; Nicos A Nicola; Manuel Baca; Warren S Alexander; Douglas J Hilton
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling.
The Journal of biological chemistry 2002;277(43):40181-4.
2002: W Douglas Fairlie; Alessandro D Uboldi; David P De Souza; George J Hemmings; Nicos A Nicola; Manuel Baca
A fusion protein system for the recombinant production of short disulfide-containing peptides.
Protein expression and purification 2002;26(1):171-8.
2002: David P De Souza; Louis J Fabri; Andrew D Nash; Douglas J Hilton; Nicos A Nicola; Manuel Baca
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.
Biochemistry 2002;41(29):9229-36.
2002: Danielle L Krebs; Rachel Uren; Donald Metcalf; Steven Rakar; Jian-Guo Zhang; Robyn Starr; David P De Souza; Kathy Hanzinikolas; Jo Eyles; Lisa M Connolly; Richard J Simpson; Nicos A Nicola; Sandra E Nicholson; Manuel Baca; Douglas J Hilton; Warren S Alexander
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Molecular and cellular biology 2002;22(13):4567-78.
2001: John Silke; Paul G Ekert; Catherine L Day; Christine J Hawkins; Manuel Baca; J Chew; Miha Pakusch; Anne M Verhagen; David L Vaux
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.
The EMBO journal 2001;20(12):3114-23.
2000: Benjamin T Kile; Elizabeth M Viney; Tracy A Willson; T C Brodnicki; Michael Cancilla; A S Herlihy; Ben A Croker; Manuel Baca; Nicos A Nicola; Douglas J Hilton; Warren S Alexander
Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.
Gene 2000;258(1-2):31-41.
2000: Elizabeth J Coulson; Kate Reid; Manuel Baca; Kylie A Shipham; S M Hulett; Trevor J Kilpatrick; Perry F Bartlett
Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death.
The Journal of biological chemistry 2000;275(39):30537-45.
2000: Sandra E Nicholson; David P De Souza; Louis J Fabri; Jason Corbin; Tracy A Willson; Jian-Guo Zhang; A Silva; M Asimakis; A Farley; Andrew D Nash; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Manuel Baca
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6493-8.
1999: Warren S Alexander; Robyn Starr; Donald Metcalf; Sandra E Nicholson; A Farley; Andrew G Elefanty; M Brysha; Benjamin T Kile; R Richardson; Manuel Baca; Jian-Guo Zhang; Tracy A Willson; Elizabeth M Viney; Naomi S Sprigg; Steven Rakar; Jason Corbin; Sandra Mifsud; Ladina DiRago; Dale Cary; Nicos A Nicola; Douglas J Hilton
Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.
Journal of leukocyte biology 1999;66(4):588-92.
1999: Jian-Guo Zhang; A Farley; Sandra E Nicholson; Tracy A Willson; L M Zugaro; Richard J Simpson; Robert L Moritz; Dale Cary; R Richardson; George Hausmann; B J Kile; S B Kent; Warren S Alexander; Donald Metcalf; Douglas J Hilton; Nicos A Nicola; Manuel Baca
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2071-6.
1999: Sandra E Nicholson; Tracy A Willson; A Farley; Robyn Starr; Jian-Guo Zhang; Manuel Baca; Warren S Alexander; Donald Metcalf; Douglas J Hilton; Nicos A Nicola
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
The EMBO journal 1999;18(2):375-85.
1999: Nicos A Nicola; Sandra E Nicholson; Donald Metcalf; Jian-Guo Zhang; Manuel Baca; A Farley; Tracy A Willson; Robyn Starr; W Alexander; Douglas J Hilton
Negative regulation of cytokine signaling by the SOCS proteins.
Cold Spring Harbor symposia on quantitative biology 1999;64():397-404.