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Carl June

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Stephan A Grupp; Bernd Hauck; Richard Aplenc; David Barrett; Anne Chew; Michael Kalos; Bruce L Levine; Michael C Milone; David L Porter; Susan R Rheingold; David Teachey; J Fraser Wright; Carl H June
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.
Marcela V Maus; Carl H June
Zoom Zoom: Racing CARs for Multiple Myeloma.
Daniel H Fowler; Juan Gea-Banacloche; Andre Goy; Ronald E Gress; Frances T Hakim; David C Halverson; Nancy M Hardy; Dennis D Hickstein; Carl H June; Hanh M Khuu; Robert Korngold; Susan F Leitman; Bruce L Levine; Jacopo Mariotti; Miriam Mossoba; Steven Z Pavletic; Andrew L Pecora; Scott Rowley; Marianna Sabatino; Claude Sportes; Seth M Steinberg; David Stroncek; Luciano Castiello; Michele Donato; Michael Bishop
Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation.

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2013: Stephan A Grupp; Bernd Hauck; Richard Aplenc; David Barrett; Anne Chew; Michael Kalos; Bruce L Levine; Michael C Milone; David L Porter; Susan R Rheingold; David Teachey; J Fraser Wright; Carl H June
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.
The New England journal of medicine 2013;368(16):1509-18.
2013: Marcela V Maus; Carl H June
Zoom Zoom: Racing CARs for Multiple Myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(8):1917-9.
2013: Daniel H Fowler; Juan Gea-Banacloche; Andre Goy; Ronald E Gress; Frances T Hakim; David C Halverson; Nancy M Hardy; Dennis D Hickstein; Carl H June; Hanh M Khuu; Robert Korngold; Susan F Leitman; Bruce L Levine; Jacopo Mariotti; Miriam Mossoba; Steven Z Pavletic; Andrew L Pecora; Scott Rowley; Marianna Sabatino; Claude Sportes; Seth M Steinberg; David Stroncek; Luciano Castiello; Michele Donato; Michael Bishop
Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation.
Blood 2013;121(15):2864-74.
2013: Emmet McCormack; Olivier Morteau; Maja Mujić; Tereza Osdal; Alex S Powlesland; malkit sami; Deborah H Sutton; Annelise Vuidepot; Katherine J Adams; Milos Aleksic; Rebecca Ashfield; Deborah Baker; Bjørn Tore Gjertsen; Namir J Hassan; Carl H June; Michael Kalos; Akhil Kotian; Nikolai M Lissin; Bent K Jakobsen
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors.
Cancer immunology, immunotherapy : CII 2013;62(4):773-85.
2013: Dawn A Maier; Elena E Perez; Gabriela Plesa; James L Riley; S Kaye Spratt; Travis Wood; Zhaohui Zheng; Dale Ando; Gwendolyn K Binder-Scholl; Andrea L Brennan; Carmine Carpenito; Richard G Carroll; Julio Cotte; Philip Gregory; Michael C Holmes; Shuguang Jiang; Carl H June; Gary Lee; Bruce L Levine
Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5.
Human gene therapy 2013;24(3):245-58.
2013: Pablo Tebas; Elizabeth Veloso; Jenny Zhan; Zhaohui Zheng; Faten Aberra; Gwendolyn Binder-Scholl; Jean Boyer; Troy Brady; Andrea L Brennan; Frederic D Bushman; Ronald G Collman; Julio Cotte; Laurent Humeau; Wei-Ting Hwang; Michael Kalos; Bruce L Levine; Adonna Mackley; Luis J Montaner; Rithun Mukherjee; Emmanouil Papasavvas; Tessio Rebello; Daniel Schullery; Farida Shaheen; Vladimir Slepushkin; David Stein; Carl H June
Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV.
Blood 2013;121(9):1524-33.
2013: Gerard J McGarrity; David Stein; Pablo Tebas; April Winemiller; Andrew Zolopa; Kris Andre; Gwen Binder-Scholl; Gary Blick; Richard N Greenberg; Gloria Hoyah; Laurent Humeau; Carl H June; Clifford Kinder; Tessio Rebello
Patient monitoring and follow-up in lentiviral clinical trials.
The journal of gene medicine 2013;15(2):78-82.
2013: Saskia J A M Santegoets; Rik J Scheper; Anita G M Stam; Megan M Suhoski; Annelies W Turksma; Alfons Jm van den Eertwegh; Winald R Gerritsen; Erik Hooijberg; Carl H June; Daniel J Powell; Steve M Albelda; Tanja D de Gruijl
IL-21 promotes the expansion of CD27+CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells.
Journal of translational medicine 2013;11():37.
2013: Stanley R Riddell; Michael C Jensen; Carl H June
Chimeric antigen receptor--modified T cells: clinical translation in stem cell transplantation and beyond.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2013;19(1 Suppl):S2-5.
2013: Naoki Kunii; Xiaojun Liu; Michael C Milone; Lawrence E Samelson; John Scholler; Yangbing Zhao; Lakshmi Balagopalan; Shuguang Jiang; Carl H June
Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.
Human gene therapy 2013;24(1):27-37.
2012: Stephan A Grupp; Abbas F Jawad; Carl H June; Bruce L Levine; Kenyetta R McDonald; Eline Luning Prak; Susanne Shusterman; Jean Boyer; Colleen Callahan; Edward Thompson; Kathleen E Sullivan
Adoptive transfer of autologous T cells improves T-cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(24):6732-41.
2012: James A Hoxie; Carl H June
Novel cell and gene therapies for HIV.
Cold Spring Harbor perspectives in medicine 2012;2(10):.
2012: Julia Tchou; Robert H Vondeheide; Liang-Chuan Wang; Hongtao Zhang; Steven M Albelda; Hossein Borghaei; Jose Conejo-Garcia; Carl H June; Michael Kalos; Ben Selven; Paul J Zhang
Mesothelin, a novel immunotherapy target for triple negative breast cancer.
Breast cancer research and treatment 2012;133(2):799-804.
2012: John Scholler; Ashley N Vogel; Michael Kalos; Bruce L Levine; Ronald T Mitsuyasu; Gabriela Plesa; James L Riley; Naomi E Aronson; Wendy B Bernstein; Gwendolyn Binder-Scholl; Troy L Brady; Frederic D Bushman; Steven G Deeks; Kristen M Hege; Wei-Ting Hwang; Carl H June
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells.
Science translational medicine 2012;4(132):132ra53.
2012: Christina S Chu; George Coukos; Victoria Gamerman; Phyllis A Gimotty; Bruce L Levine; Mark A Morgan; Stephen C Rubin; Daniel S Schullery; Robert H Vonderheide; James Bender; Jean Boyer; Carl H June
Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission.
Cancer immunology, immunotherapy : CII 2012;61(5):629-41.
2012: Nancy M Hardy; Carl H June; Hanh M Khuu; Roger J Kurlander; Bruce L Levine; Sarfraz Memon; Esther Mena; Jeanne Odom; Stefania Pittaluga; Ran Reshef; Jeremy J Rose; Seth M Steinberg; Maryalice Stetler-Stevenson; Robert H Vonderheide; Bazetta Blacklock-Schuver; Andrew J Dwyer; Vicki Fellowes; Daniel H Fowler; Ronald E Gress; Frances T Hakim; Daniele N Avila; Michael Bishop
Costimulated tumor-infiltrating lymphocytes are a feasible and safe alternative donor cell therapy for relapse after allogeneic stem cell transplantation.
Blood 2012;119(12):2956-9.
2012: Adham S Bear; Gwendolyn Binder-Scholl; Kenneth Cornetta; Mark E Dudley; Steven A Feldman; Helen E Heslop; Carl H June; Richard A Morgan; Cliona M Rooney; STEVEN ROSENBERG; Sheila A Shurtleff; Gianpietro Dotti
Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(2):246-9.
2011: Keli L Hippen; Carl H June; James L Riley; Bruce R Blazar
Clinical perspectives for regulatory T cells in transplantation tolerance.
Seminars in immunology 2011;23(6):462-8.
2011: Shoba Amarnath; Tania C Felizardo; Jason E Foley; Alice He; Carl H June; Veena Kapoor; Bruce L Levine; Courtney W Mangus; Paul R Massey; Jeffrey A Medin; James L Riley; James C M Wang; Fang Wei; Daniel H Fowler
The PDL1-PD1 axis converts human TH1 cells into regulatory T cells.
Science translational medicine 2011;3(111):111ra120.
2011: Scott L Butler; David A Cooper; Daniel Douek; Jeffrey M Jacobson; Carl H June; Michael M Lederman; Yves Levy; Manos Perros; Hernan Valdez; Mike Westby; Pablo Tebas
Disease-modifying therapeutic concepts for HIV in the era of highly active antiretroviral therapy.
Journal of acquired immune deficiency syndromes (1999) 2011;58(3):297-303.
2011: David Maxwell Barrett; Carmine Carpenito; Jonathan D Fish; Stephan A Grupp; Carl H June; Alix E Seif; David Teachey; Gregor S D Reid
Noninvasive bioluminescent imaging of primary patient acute lymphoblastic leukemia: a strategy for preclinical modeling.
Blood 2011;118(15):e112-7.
2011: Luca Gattinoni; Emma Gostick; Yun Ji; Carl H June; Enrico Lugli; Francesco M Marincola; Chrystal M Paulos; Zoltan Pos; David A Price; Máire F Quigley; Jorge Almeida; Carmine Carpenito; Daniel C Douek; Mario Roederer; Ena Wang; Zhiya Yu; Nicholas P Restifo
A human memory T cell subset with stem cell-like properties.
Nature medicine 2011;17(10):1290-7.
2011: David L Porter; Adam Bagg; Michael Kalos; Bruce L Levine; Carl H June
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.
The New England journal of medicine 2011;365(8):725-33.
2011: Michael Kalos; Sharyn Katz; Bruce L Levine; David L Porter; Adam Bagg; Stephan A Grupp; Carl H June
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.
Science translational medicine 2011;3(95):95ra73.
2011: Edmund K Moon; Daniel J Powell; Jarrod Predina; James L Riley; Jing Sun; Liang-Chuan S Wang; Carmine Carpenito; Carl H June; Veena Kapoor; Steven M Albelda
Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(14):4719-30.
2011: De-Gang Song; Li-Ping Wang; Qunrui Ye; Carmine Carpenito; George Coukos; Mariangela Figini; Chunyan Ji; Carl H June; Mathilde Poussin; Daniel J Powell
In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB).
Cancer research 2011;71(13):4617-27.
2011: Keli L Hippen; Carl H June; S C Merkel; Jeffrey S Miller; C Nelson; James L Riley; D K Schirm; N C Tennis; John E Wagner; Bruce R Blazar
Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(6):1148-57.
2011: Keli L Hippen; Sarah C Merkel; Dawn K Schirm; Christine M Sieben; Darin Sumstad; Diane M Kadidlo; David H McKenna; Jonathan Bromberg; Bruce L Levine; James L Riley; Carl H June; Phillip Scheinberg; Daniel C Douek; Jeffrey S Miller; John E Wagner; Bruce R Blazar
Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity.
Science translational medicine 2011;3(83):83ra41.
2011: Hildegund C J Ertl; Carl H June; Jeffrey Kahn; STEVEN ROSENBERG; Laurence J N Cooper; Jacqueline Corrigan-Curay; Gianpietro Dotti; John Zaia; Scott E Strome
Considerations for the clinical application of chimeric antigen receptor T cells: observations from a recombinant DNA Advisory Committee Symposium held June 15, 2010.
Cancer research 2011;71(9):3175-81.
2011: Craig B Wilen; Jianbin Wang; John C Tilton; Jeffrey C Miller; Kenneth A Kim; Edward J Rebar; Scott A Sherrill-Mix; Sean C Patro; Anthony J Secreto; Andrea P O Jordan; Gary Lee; Joshua Kahn; Pyone Aye; Bruce A Bunnell; Andrew A Lackner; James A Hoxie; Gwenn A Danet-Desnoyers; Frederic D Bushman; James L Riley; Philip D Gregory; Carl H June; Michael C Holmes; Robert W Doms
Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.
PLoS pathogens 2011;7(4):e1002020.
2011: Michael Bishop; Edwin P Alyea; Mitchell S Cairo; J H Frederik Falkenburg; Carl H June; Nicolaus Kröger; Richard F Little; Jeffrey S Miller; Steven Z Pavletic; David L Porter; Stanley R Riddell; Koen van Besien; ALAN WAYNE; Daniel J Weisdorf; Roy S Wu; Sergio Giralt
National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2011;17(4):443-54.
2011: Donald B Kohn; Gianpietro Dotti; Renier Brentjens; Barbara Savoldo; Michael Jensen; Laurence J N Cooper; Carl H June; STEVEN ROSENBERG; Michel Sadelain; Helen E Heslop
CARs on track in the clinic.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(3):432-8.
2011: Aaron P Rapoport; Nicole A Aqui; Edward A Stadtmauer; Dan T Vogl; Hongbin Fang; Ling Cai; Stephen Janofsky; Anne Chew; Jan Storek; Gorgun Akpek; Ashraf Badros; Saul Yanovich; Ming Tan; Elizabeth Veloso; Marcela F Pasetti; Alan S Cross; Sunita Philip; Heather Murphy; Rita Bhagat; Zhaohui Zheng; Todd Milliron; Julio Cotte; Andrea Cannon; Bruce L Levine; Robert H Vonderheide; Carl H June
Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma.
Blood 2011;117(3):788-97.
2011: Claudio G Brunstein; Jeffrey S Miller; Qing Cao; David H McKenna; Keli L Hippen; Julie Curtsinger; Todd E DeFor; Bruce L Levine; Carl H June; Pablo Rubinstein; Philip B McGlave; Bruce R Blazar; John E Wagner
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics.
Blood 2011;117(3):1061-70.
2011: Edward A Stadtmauer; Dan T Vogl; Eline Luning Prak; Jean Boyer; Nicole A Aqui; Aaron P Rapoport; Kenyetta R McDonald; Xiaoling Hou; Heather Murphy; Rita Bhagat; Patricia A Mangan; Anne Chew; Elizabeth A Veloso; Bruce L Levine; Robert H Vonderheide; Abbas F Jawad; Carl H June; Kathleen E Sullivan
Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial.
Blood 2011;117(1):63-71.
2011: Qunrui Ye; James L Riley; Megan M Suhoski; George Coukos; Carl H June; Bruce L Levine; Maria Loisiou; Daniel J Powell
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes.
Journal of translational medicine 2011;9():131.
2011: Ioannis Alagkiozidis; Fabian Benencia; Carmine Carpenito; Andrea Facciabene; Zdenka L Jonak; Carl H June; Daniel J Powell; Marinos Tsiatas; Sarah Adams; George Coukos
Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy.
Journal of translational medicine 2011;9():77.
2011: Stephan A Grupp; Carl H June
Adoptive cellular therapy.
Current topics in microbiology and immunology 2011;344():149-72.
2010: Yangbing Zhao; Edmund Moon; Carmine Carpenito; Chrystal M Paulos; Xiaojun Liu; Andrea L Brennan; Anne Chew; Richard G Carroll; John Scholler; Bruce L Levine; Steven M Albelda; Carl H June
Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor.
Cancer research 2010;70(22):9053-61.
2010: Chrystal M Paulos; Carmine Carpenito; Gabriela Plesa; Megan M Suhoski; Angel Varela-Rohena; Tatiana N Golovina; Richard G Carroll; James L Riley; Carl H June
The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.
Science translational medicine 2010;2(55):55ra78.
2010: Qing Zhou; Meghan E Munger; Steven L Highfill; Jakub Tolar; Brenda J Weigel; Megan Riddle; Arlene H Sharpe; Daniel A Vallera; Miyuki Azuma; Bruce L Levine; Carl H June; William Murphy; David H Munn; Bruce R Blazar
Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.
Blood 2010;116(14):2484-93.
2010: Lawrence H Boise; Andy J Minn; Patricia J Noel; Carl H June; Mary Ann Accavitti; Tullia Lindsten; Craig Thompson
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL. Immunity. 1995. 3: 87-98.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):3788-99.
2010: Gregory B Lesinski; William E Carson; Elizabeth A Repasky; Wei-Zen Wei; Pawel Kalinski; Michael T Lotze; Carl H June; William Petros; Natarajan Muthusamy; Thomas Olencki
Meeting report: The 13th Annual Meeting of the Translational Research Cancer Centers Consortium (TrC3); Immune Suppression and the Tumor Microenvironment, Columbus, Ohio; March 1-2, 2010.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(7):659-62.
2010: Mitchell S Cairo; Craig T Jordan; Carlo C Maley; K.S. Chao; Ari Melnick; Scott A Armstrong; Warren Shlomchik; Jeff Molldrem; Soldano Ferrone; CRYSTAL MACKALL; Laurence Zitvogel; Michael Bishop; Sergio Giralt; Carl H June
NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010;16(6):709-28.
2010: Shoba Amarnath; Carliann M Costanzo; Michael Eckhaus; Francis A Flomerfelt; Jason E Foley; Anu Gangopadhyay; Carl H June; Daniel M Konecki; Bruce L Levine; Jacopo Mariotti; Susan Wong; Daniel H Fowler
Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD.
Autophagy 2010;6(4):523-41.
2010: Michael Bishop; Edwin P Alyea; Mitchell S Cairo; J H Frederik Falkenburg; Carl H June; Nicolaus Kröger; Richard F Little; Jeffrey S Miller; Steven Z Pavletic; David Porter; Stanley R Riddell; Koen van Besien; ALAN WAYNE; Daniel J Weisdorf; Roy Wu; Sergio Giralt
Introduction to the reports from the National Cancer Institute First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010;16(5):563-4.
2010: Daniel H Sterman; Adri Recio; Andrew R Haas; Anil Vachani; Sharyn I Katz; Colin T Gillespie; Guanjun Cheng; Jing Sun; Edmund Moon; Luana Pereira; Xinzhong Wang; Daniel F Heitjan; Leslie Litzky; Carl H June; Robert H Vonderheide; Richard G Carroll; Steven M Albelda
A phase I trial of repeated intrapleural adenoviral-mediated interferon-beta gene transfer for mesothelioma and metastatic pleural effusions.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(4):852-60.
2010: Shoba Amarnath; Carliann M Costanzo; Jacopo Mariotti; Jessica L Ullman; William G Telford; Veena Kapoor; James L Riley; Bruce L Levine; Carl H June; Timothy Fong; Noel L Warner; Daniel H Fowler
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
PLoS biology 2010;8(2):e1000302.
2010: Chrystal M Paulos; Carl H June
Putting the brakes on BTLA in T cell-mediated cancer immunotherapy.
The Journal of clinical investigation 2010;120(1):76-80.
2010: Syam Tammana; Xin Huang; Marianna Wong; Michael C Milone; Linan Ma; Bruce L Levine; Carl H June; John E Wagner; Bruce R Blazar; Xianzheng Zhou
4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies.
Human gene therapy 2010;21(1):75-86.
2009: Qing Zhou; christoph bucher; Meghan E Munger; Steven L Highfill; Jakub Tolar; David H Munn; Bruce L Levine; Megan Riddle; Carl H June; Daniel A Vallera; Brenda J Weigel; Bruce R Blazar
Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia.
Blood 2009;114(18):3793-802.
2009: Carl H June; Bruce R Blazar; James L Riley
Engineering lymphocyte subsets: tools, trials and tribulations.
Nature reviews. Immunology 2009;9(10):704-16.
2009: Yozo Nakazawa; Leslie E Huye; Gianpietro Dotti; Aaron E Foster; Juan F Vera; Pallavi R Manuri; Carl H June; Cliona M Rooney; Matthew H Wilson
Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(8):826-36.
2009: Michael C Milone; Jonathan D Fish; Carmine Carpenito; Richard G Carroll; Gwendolyn K Binder; David Teachey; Minu Samanta; Mehdi Lakhal; Brian Gloss; Gwenn Danet-Desnoyers; Dario Campana; James L Riley; Stephan A Grupp; Carl H June
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(8):1453-64.
2009: Aaron P Rapoport; Edward A Stadtmauer; Nicole Aqui; Dan Vogl; Anne Chew; Hongbin Fang; Stephen Janofsky; Kelly Yager; Elizabeth Veloso; Zhaohui Zheng; Todd Milliron; Sandra Westphal; Julio Cotte; Hong Huynh; Andrea Cannon; Saul Yanovich; Gorgun Akpek; Ming Tan; Kristen Virts; Kathy Ruehle; Carolynn Harris; Sunita Philip; Robert H Vonderheide; Bruce L Levine; Carl H June
Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4499-507.
2009: James L Riley; Carl H June; Bruce R Blazar
Human T regulatory cell therapy: take a billion or so and call me in the morning.
Immunity 2009;30(5):656-65.
2009: Gary P Wang; Bruce L Levine; Gwendolyn K Binder; Charles C Berry; Nirav Malani; Gary McGarrity; Pablo Tebas; Carl H June; Frederic D Bushman
Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(5):844-50.
2009: Carmine Carpenito; Michael C Milone; Raffit Hassan; Jacqueline C Simonet; Mehdi Lakhal; Megan M Suhoski; Angel Varela-Rohena; Kathleen M Haines; Daniel F Heitjan; Steven M Albelda; Richard G Carroll; James L Riley; Ira Pastan; Carl H June
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3360-5.
2009: Ioannis Alagkiozidis; Andrea Facciabene; Carmine Carpenito; Fabian Benencia; Zdenka L Jonak; Sarah Adams; Richard G Carroll; Phyllis A Gimotty; Rachel Hammond; Gwen-äel Danet-Desnoyers; Carl H June; Daniel J Powell; George Coukos
Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18.
Journal of translational medicine 2009;7():104.
2008: Angel Varela-Rohena; Peter E Molloy; Steven M Dunn; Yi Li; Megan M Suhoski; Richard G Carroll; Anita Milicic; Tara Mahon; Deborah H Sutton; Bruno Laugel; Ruth Moysey; Brian J Cameron; Annelise Vuidepot; Marco A Purbhoo; david cole; Rodney E Phillips; Carl H June; Bent K Jakobsen; Andrew K Sewell; James L Riley
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.
Nature medicine 2008;14(12):1390-5.
2008: Keli L Hippen; Paul Harker-Murray; Stephen B Porter; Sarah C Merkel; Aryel Londer; Dawn K Taylor; Megan Bina; Angela Panoskaltsis-Mortari; Pablo Rubinstein; Nico van Rooijen; Tatiana N Golovina; Megan M Suhoski; Jeffrey S Miller; John E Wagner; Carl H June; James L Riley; Bruce R Blazar
Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells.
Blood 2008;112(7):2847-57.
2008: Nicole A Aqui; Carl H June
Post-transplant adoptive T-cell immunotherapy.
Best practice & research. Clinical haematology 2008;21(3):503-19.
2008: Tatiana N Golovina; Tatiana Mikheeva; Megan M Suhoski; Nicole A Aqui; Victoria C Tai; Xiaochuan Shan; Ronghua Liu; R Robert Balcarcel; Nancy Fisher; Bruce L Levine; Richard G Carroll; Noel Warner; Bruce R Blazar; Carl H June; James L Riley
CD28 costimulation is essential for human T regulatory expansion and function.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2855-68.
2008: M M Suhoski; E E Perez; M L Heltzer; A Laney; Lisa Shaffer; S Saitta; S Nachman; Nancy B Spinner; Carl H June; Jordan S Orange
Monosomy 1p36 uncovers a role for OX40 in survival of activated CD4+ T cells.
Clinical immunology (Orlando, Fla.) 2008;128(2):181-9.
2008: Elena E Perez; Jianbin Wang; Jeffrey C Miller; Yann Jouvenot; Kenneth A Kim; Olga Liu; Nathaniel Wang; Gary Lee; Victor V Bartsevich; Ya-Li Lee; Dmitry Y Guschin; Igor Rupniewski; Adam J Waite; Carmine Carpenito; Richard G Carroll; Jordan S Orange; Fyodor D Urnov; Edward J Rebar; Dale Ando; Philip D Gregory; James L Riley; Michael C Holmes; Carl H June
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases.
Nature biotechnology 2008;26(7):808-16.
2008: Africa Wallace; Veena Kapoor; Jing Sun; Paul Mrass; Wolfgang Weninger; Daniel F Heitjan; Carl H June; Larry R Kaiser; Leona E Ling; Steven M Albelda
Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(12):3966-74.
2008: Samik Basu; Tatiana Golovina; Tatiana Mikheeva; Carl H June; James L Riley
Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5794-8.
2008: Xin Huang; Hongfeng Guo; Johnthomas Kang; Suet Choi; Tom C Zhou; Syam Tammana; Christopher J Lees; Zhong-Ze Li; Michael Milone; Bruce L Levine; Jakub Tolar; Carl H June; R Scott McIvor; John E Wagner; Bruce R Blazar; Xianzheng Zhou
Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):580-9.
2008: Christina S Chu; Sarah H Kim; Carl H June; George Coukos
Immunotherapy opportunities in ovarian cancer.
Expert review of anticancer therapy 2008;8(2):243-57.
2008: Richard G Carroll; Carmine Carpenito; Xiaochuan Shan; Gwenn Danet-Desnoyers; Ronghua Liu; Shuguang Jiang; Steven M Albelda; Tatiana Golovina; George Coukos; James L Riley; Zdenka L Jonak; Carl H June
Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells.
PloS one 2008;3(9):e3289.
2007: John J Rossi; Carl H June; Donald B Kohn
Genetic therapies against HIV.
Nature biotechnology 2007;25(12):1444-54.
2007: Gabriela Plesa; Jihong Dai; Cliff Baytop; James L Riley; Carl H June; Una O'Doherty
Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells.
Journal of virology 2007;81(24):13938-42.
2007: Elizabeth Hexner; Gwenn-Aël H Danet-Desnoyers; Yi Zhang; Dale M Frank; James L Riley; Bruce L Levine; David Porter; Carl H June; Stephen G Emerson
Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(10):1135-44.
2007: Hua Zhang; Kristen M Snyder; Megan M Suhoski; Marcela V Maus; Veena Kapoor; Carl H June; CRYSTAL MACKALL
4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4910-8.
2007: Daniel H Sterman; Adri Recio; Richard G Carroll; Colin T Gillespie; Andrew Haas; Anil Vachani; Veena Kapoor; Jing Sun; Richard L Hodinka; Jennifer L Brown; Michael J Corbley; Michael Parr; Mitchell Ho; Ira Pastan; Michael Machuzak; William Benedict; Xin-qiao Zhang; Elaina M Lord; Leslie A Litzky; Daniel F Heitjan; Carl H June; Larry R Kaiser; Robert H Vonderheide; Steven M Albelda; Michelle Kanther
A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor immune responses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 1):4456-66.
2007: Carl H June
Adoptive T cell therapy for cancer in the clinic.
The Journal of clinical investigation 2007;117(6):1466-76.
2007: Carl H June
Principles of adoptive T cell cancer therapy.
The Journal of clinical investigation 2007;117(5):1204-12.
2007: Richard G Carroll; Carl H June
Programming the next generation of dendritic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(5):846-8.
2007: Megan M Suhoski; Tatiana N Golovina; Nicole A Aqui; Victoria C Tai; Angel Varela-Rohena; Michael C Milone; Richard G Carroll; James L Riley; Carl H June
Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(5):981-8.
2007: Brian J Czerniecki; Gary K Koski; Ursula Koldovsky; Shuwen Xu; Peter A Cohen; Rosemarie Mick; Harvey Nisenbaum; Terry Pasha; Min Xu; Kevin R Fox; Susan Weinstein; Susan G Orel; Robert H Vonderheide; George Coukos; Angela DeMichele; Louis Araujo; Francis R Spitz; Mark Rosen; Bruce L Levine; Carl H June; Paul J Zhang
Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion.
Cancer research 2007;67(4):1842-52.
2007: James L Riley; Carl H June
The road to recovery: translating PD-1 biology into clinical benefit.
Trends in immunology 2007;28(2):48-50.
2007: Natalie A Christian; Michael C Milone; Shraddha S Ranka; Guizhi Li; Paul R Frail; Kevin P Davis; Frank S Bates; Michael J Therien; P Peter Ghoroghchian; Carl H June; Daniel A Hammer
Tat-functionalized near-infrared emissive polymersomes for dendritic cell labeling.
Bioconjugate chemistry 2007;18(1):31-40.
2006: Bruce L Levine; Laurent Humeau; Jean Boyer; Rob Roy MacGregor; Tessio Rebello; Xiaobin Lu; Gwendolyn K Binder; Vladimir Slepushkin; Franck Lemiale; John R Mascola; Frederic D Bushman; Boro Dropulic; Carl H June
Gene transfer in humans using a conditionally replicating lentiviral vector.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17372-7.
2006: Daniel H Fowler; Jeanne Odom; Seth M Steinberg; Catherine K Chow; Jason Foley; Yelena Kogan; Jeannie Hou; Juan Gea-Banacloche; Claude Sportes; Steven Z Pavletic; Susan F Leitman; Elizabeth J Read; Charles Carter; Arne Kolstad; Rebecca Fox; Gregory L Beatty; Robert H Vonderheide; Bruce L Levine; Carl H June; Ronald E Gress; Michael Bishop
Phase I clinical trial of costimulated, IL-4 polarized donor CD4+ T cells as augmentation of allogeneic hematopoietic cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(11):1150-60.
2006: Daniel H Sterman; Colin T Gillespie; Richard G Carroll; Christina M Coughlin; Elaina M Lord; Jing Sun; Andrew Haas; Adri Recio; Larry R Kaiser; George Coukos; Carl H June; Steven M Albelda; Robert H Vonderheide
Interferon beta adenoviral gene therapy in a patient with ovarian cancer.
Nature clinical practice. Oncology 2006;3(11):633-9.
2006: Stephen B Porter; Baoling Liu; John Rogosheske; Bruce L Levine; Carl H June; Virginia K Kohl; John E Wagner; Jeffrey S Miller; Bruce R Blazar
Suppressor function of umbilical cord blood-derived CD4+CD25+ T-regulatory cells exposed to graft-versus-host disease drugs.
Transplantation 2006;82(1):23-9.
2006: Boro Dropulic; Carl H June
Gene-based immunotherapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome.
Human gene therapy 2006;17(6):577-88.
2006: Carl H June; Bruce R Blazar
Clinical application of expanded CD4+25+ cells.
Seminars in immunology 2006;18(2):78-88.
2006: David Porter; Bruce L Levine; Nancy Bunin; Edward A Stadtmauer; Selina M Luger; Steven Goldstein; Alison W Loren; Julie Phillips; Sunita D Nasta; Alexander Perl; Steven Schuster; Donald Tsai; Ambika Sohal; Elizabeth Veloso; Stephen Emerson; Carl H June
A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation.
Blood 2006;107(4):1325-31.
2006: Xin Huang; Andrew Wilber; Lei Bao; Dong Tuong; Jakub Tolar; Paul J Orchard; Bruce L Levine; Carl H June; R Scott McIvor; Bruce R Blazar; Xianzheng Zhou
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system.
Blood 2006;107(2):483-91.
2005: Michael C Milone; Carl H June
Adoptive immunotherapy: new ways to skin the cat?
Clinical immunology (Orlando, Fla.) 2005;117(2):101-3.
2005: David Porter; Carl H June
T-cell reconstitution and expansion after hematopoietic stem cell transplantation: 'T' it up!
Bone marrow transplantation 2005;35(10):935-42.
2005: E E Perez; James L Riley; Richard G Carroll; D von Laer; Carl H June
Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed gp41-derived fusion inhibitor.
Clinical immunology (Orlando, Fla.) 2005;115(1):26-32.
2005: Peter DeLong; Richard G Carroll; Adam C Henry; Tomoyuki Tanaka; Sajjad Ahmad; Michael S Leibowitz; Daniel H Sterman; Carl H June; Steven M Albelda; Robert H Vonderheide
Regulatory T cells and cytokines in malignant pleural effusions secondary to mesothelioma and carcinoma.
Cancer biology & therapy 2005;4(3):342-6.
2005: Wayne Godfrey; Darrin J Spoden; Ying G Ge; Seth R Baker; Baoling Liu; Bruce L Levine; Carl H June; Bruce R Blazar; Stephen B Porter
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Blood 2005;105(2):750-8.
2005: Peter Manilla; Tessio Rebello; Cathleen Afable; Xiaobin Lu; Vladimir Slepushkin; Laurent Humeau; Kathy Schonely; Yajin Ni; Gwendolyn K Binder; Bruce L Levine; Rob Roy MacGregor; Carl H June; Boro Dropulic
Regulatory considerations for novel gene therapy products: a review of the process leading to the first clinical lentiviral vector.
Human gene therapy 2005;16(1):17-25.
2005: James L Riley; Carl H June
The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.
Blood 2005;105(1):13-21.
2004: Carl H June; Jonni S Moore
Measurement of intracellular ions by flow cytometry.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2004;Chapter 5():Unit 5.5.
2004: Patricia A Taylor; Angela Panoskaltsis-Mortari; Jessica M Swedin; Philip J Lucas; Ronald E Gress; Bruce L Levine; Carl H June; Jonathan S Serody; Bruce R Blazar
L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection.
Blood 2004;104(12):3804-12.
2004: Jens M Chemnitz; Richard V Parry; Kim E Nichols; Carl H June; James L Riley
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):945-54.
2004: Wayne Godfrey; Ying G Ge; Darrin J Spoden; Bruce L Levine; Carl H June; Bruce R Blazar; Stephen B Porter
In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.
Blood 2004;104(2):453-61.
2004: Laurent Humeau; Gwendolyn K Binder; Xiaobin Lu; Vladimir Slepushkin; Randall Merling; Patricia Echeagaray; Mario Pereira; Tatiana Slepushkina; Scott Barnett; Lesia K Dropulic; Richard Carroll; Bruce L Levine; Carl H June; Boro Dropulic
Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(6):902-13.
2004: Martin G Sauer; Marna E Ericson; Brenda J Weigel; Michael J Herron; Angela Panoskaltsis-Mortari; Betsy T Kren; Bruce L Levine; Jonathan S Serody; Carl H June; Patricia A Taylor; Bruce R Blazar
A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cells.
Cancer research 2004;64(11):3914-21.
2004: Marcela V Maus; Birgit Kovacs; William W Kwok; Gerald Nepom; Katia Schlienger; James L Riley; David Allman; Terri H Finkel; Carl H June
Extensive replicative capacity of human central memory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):6675-83.
2004: Waleed S W Shalaby; Heidi Yeh; Edward Woo; Joel T Corbett; Heidi Gray; Carl H June; Shalaby W Shalaby
Absorbable microparticulate cation exchanger for immunotherapeutic delivery.
Journal of biomedical materials research. Part B, Applied biomaterials 2004;69(2):173-82.
2004: Yi Zhang; Gerard Joe; Jiang Zhu; Richard Carroll; Bruce Levine; Elizabeth Hexner; Carl H June; Stephen G Emerson
Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity.
Blood 2004;103(10):3970-8.
2003: Ginna G Laport; Bruce L Levine; Edward A Stadtmauer; Stephen J Schuster; Selina M Luger; Stephan A Grupp; Nancy Bunin; Frank J Strobl; Julio Cotte; Zhaohui Zheng; Brian Gregson; Patricia M Rivers; Robert H Vonderheide; David N Liebowitz; David Porter; Carl H June
Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation.
Blood 2003;102(6):2004-13.
2003: Hua Zhang; Melinda S Merchant; Kevin S Chua; Chand Khanna; Lee Helman; Bill Telford; Yvona Ward; Jeffrey Summers; Jeffrey A Toretsky; Elaine K Thomas; Carl H June; CRYSTAL MACKALL
Tumor expression of 4-1BB ligand sustains tumor lytic T cells.
Cancer biology & therapy 2003;2(5):579-86.
2003: Richard V Parry; Carl H June
Calcium-independent calcineurin regulation.
Nature immunology 2003;4(9):821-3.
2003: Waleed S W Shalaby; Heidi Yeh; Edward Woo; Samantha K Hendren; Joel T Corbett; Heidi Gray; Carl H June; Shalaby W Shalaby
Development of novel substrates for tumor immunotherapy.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(1-2):209-24.
2003: Richard V Parry; Catherine A Rumbley; Luk Vandenberghe; Carl H June; James L Riley
CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):166-74.
2003: Mathias Oelke; Marcela V Maus; Dominic Didiano; Carl H June; Andreas Mackensen; Jonathan P Schneck
Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells.
Nature medicine 2003;9(5):619-24.
2003: Katia Schlienger; Christina S Chu; Edward Y Woo; Patricia M Rivers; Alanna J Toll; Brian Hudson; Marcela V Maus; James L Riley; Yongwon Choi; George Coukos; Larry R Kaiser; Stephen C Rubin; Bruce L Levine; Richard G Carroll; Carl H June
TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(4):1517-27.
2003: Robert H Vonderheide; Carl H June
A translational bridge to cancer immunotherapy: exploiting costimulation and target antigens for active and passive T cell immunotherapy.
Immunologic research 2003;27(2-3):341-56.
2003: Heidi Yeh; Carl H June
Use of cell-based therapies for modification of host immune responses.
Developments in biologicals 2003;112():99-104.
2003: Marcela V Maus; James L Riley; William W Kwok; Gerald Nepom; Carl H June
HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells.
Clinical immunology (Orlando, Fla.) 2003;106(1):16-22.
2002: Anna K Thomas; Marcela V Maus; Waleed S W Shalaby; Carl H June; James L Riley
A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes.
Clinical immunology (Orlando, Fla.) 2002;105(3):259-72.
2002: Birgit Kovacs; Marcela V Maus; James L Riley; Geo S Derimanov; Gary A Koretzky; Carl H June; Terri H Finkel
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15006-11.
2002: Mary A Marovich; John R Mascola; Michael A Eller; Mark K Louder; Pierre A Caudrelier; Raphaelle El Habib; Silvia Ratto-Kim; Josephine H Cox; Jeffrey R Currier; Bruce L Levine; Carl H June; Wendy B Bernstein; Merlin L Robb; Beatrice Schuler-Thurner; Ralph M Steinman; Deborah L Birx; Sarah Schlesinger-Frankel
Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells.
The Journal of infectious diseases 2002;186(9):1242-52.
2002: James L Riley; Mao Mao; Sumire Kobayashi; Matt Biery; Julja Burchard; Guy Cavet; Brian P Gregson; Carl H June; Peter Linsley
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11790-5.
2002: Kenneth A Frauwirth; James L Riley; Marian H Harris; Richard V Parry; Jeffrey C Rathmell; David Plas; Rebecca L Elstrom; Carl H June; Craig Thompson
The CD28 signaling pathway regulates glucose metabolism.
Immunity 2002;16(6):769-77.
2002: Steven G Deeks; Bridget Wagner; Peter A Anton; Ronald T Mitsuyasu; David T Scadden; Christine Huang; Catherine Macken; Douglas D Richman; Cindy Christopherson; Carl H June; Richard Lazar; David F Broad; Sayeh Jalali; Kristen M Hege
A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):788-97.
2002: Edward Y Woo; Heidi Yeh; Christina S Chu; Katia Schlienger; Richard G Carroll; James L Riley; Larry R Kaiser; Carl H June
Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4272-6.
2002: Christina S Chu; Edward Y Woo; Alanna J Toll; Stephen C Rubin; Carl H June; Richard G Carroll; Katia Schlienger
Tumor-associated macrophages as a source of functional dendritic cells in ovarian cancer patients.
Clinical immunology (Orlando, Fla.) 2002;102(3):291-301.
2002: Marcela V Maus; Anna K Thomas; Debra G B Leonard; David Allman; Kathakali Addya; Katia Schlienger; James L Riley; Carl H June
Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.
Nature biotechnology 2002;20(2):143-8.
2002: Francios VILLINGER; Gary T Brice; Ann Mayne; Pavel Bostik; Kazuyasu Mori; Carl H June; Aftab A Ansari
Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status.
Blood 2002;99(2):590-9.
2002: D Fowler; J Hou; Jason Foley; Frances T Hakim; Jeanne Odom; Kathleen Castro; Charles Carter; Elizabeth J Read; Juan Gea-Banacloche; Claude Kasten-Sportes; Larry W Kwak; W Wilson; B Levine; Carl H June; Ronald E Gress; Michael Bishop
Phase I clinical trial of donor T-helper type-2 cells after immunoablative, reduced intensity allogeneic PBSC transplant.
Cytotherapy 2002;4(5):429-30.
2002: Bruce L Levine; Wendy B Bernstein; Naomi E Aronson; Katia Schlienger; Julio Cotte; Steven Perfetto; Mary J Humphries; Silvia Ratto-Kim; Deborah L Birx; Carolyn Steffens; Alan Landay; Richard G Carroll; Carl H June
Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection.
Nature medicine 2002;8(1):47-53.
2001: Anna K Thomas; Carl H June
The promise of T-lymphocyte immunotherapy for the treatment of malignant disease.
Cancer journal (Sudbury, Mass.) 2001;7 Suppl 2():S67-75.
2001: Carl H June
Can't get any help? New approaches for adoptive immunotherapy of cancer.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2001;24(5):389-91.
2001: Edward Y Woo; Christina S Chu; Theresa J Goletz; Katia Schlienger; Heidi Yeh; George Coukos; Stephen C Rubin; Larry R Kaiser; Carl H June
Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.
Cancer research 2001;61(12):4766-72.
2001: Abdel Rahim A Hamad; A Srikrishnan; P Mirmonsef; C P Broeren; Carl H June; Drew M Pardoll; Jonathan P Schneck
Lack of coreceptor allows survival of chronically stimulated double-negative alpha/beta T cells: implications for autoimmunity.
The Journal of experimental medicine 2001;193(10):1113-21.
2001: James L Riley; Patrick J Blair; J T Musser; R Abe; K Tezuka; T Tsuji; Carl H June
ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):4943-8.
2000: C P Broeren; G S Gray; BM Carreno; Carl H June
Costimulation light: activation of CD4+ T cells with CD80 or CD86 rather than anti-CD28 leads to a Th2 cytokine profile.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6908-14.
2000: Katia Schlienger; Nancy Craighead; Kelvin P Lee; Bruce L Levine; Carl H June
Efficient priming of protein antigen-specific human CD4(+) T cells by monocyte-derived dendritic cells.
Blood 2000;96(10):3490-8.
2000: Isett Laux; A Khoshnan; Charles Tindell; David Bae; Xiaoming Zhu; Carl H June; Rita B Effros; Andre E Nel
Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging.
Clinical immunology (Orlando, Fla.) 2000;96(3):187-97.
2000: Ronald T Mitsuyasu; Peter A Anton; Steven G Deeks; David T Scadden; E Connick; M T Downs; A Bakker; MR Roberts; Carl H June; S Jalali; A A Lin; R Pennathur-Das; Kristen M Hege
Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects.
Blood 2000;96(3):785-93.
2000: James L Riley; Katia Schlienger; Patrick J Blair; BM Carreno; Nancy Craighead; D Kim; Richard G Carroll; Carl H June
Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule.
The Journal of experimental medicine 2000;191(11):1987-97.
2000: Patrick J Blair; James L Riley; David M Harlan; R Abe; Douglas K Tadaki; Steven C Hoffmann; L White; T Francomano; S J Perfetto; Allan D Kirk; Carl H June
CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis.
The Journal of experimental medicine 2000;191(4):651-60.
1999: A Khoshnan; SJ Kempiak; Brydon L Bennett; David Bae; W Xu; Anthony Manning; Carl H June; Andre E Nel
Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5444-52.
1999: Peter J Perrin; Carl H June; J H Maldonado; Robert B Ratts; Michael K Racke
Blockade of CD28 during in vitro activation of encephalitogenic T cells or after disease onset ameliorates experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1704-10.
1999: S Kaushal; Alan L Landay; M M Lederman; Elizabeth Connick; John Spritzler; D R Kuritzkes; H Kessler; Bruce L Levine; DC St Louis; Carl H June
Increases in T cell telomere length in HIV infection after antiretroviral combination therapy for HIV-1 infection implicate distinct population dynamics in CD4+ and CD8+ T cells.
Clinical immunology (Orlando, Fla.) 1999;92(1):14-24.
1999: Kebin Liu; M M Schoonmaker; Bruce L Levine; Carl H June; Richard J Hodes; Nan-ping Weng
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):5147-52.
1999: DC St Louis; J B Woodcock; G Franzoso; Patrick J Blair; Louise M Carlson; M Murillo; Mark R Wells; A J Williams; D S Smoot; S Kaushal; J L Grimes; David M Harlan; John P Chute; Carl H June; Ulrich Siebenlist; Kelvin P Lee; G Fransozo
Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3237-48.
1999: D Liebowitz; Carl H June
Flow cytometry in the evaluation of immune status in cancer and HIV infection.
Cytotherapy 1999;1(4):335.
1998: David N Liebowitz; K P Lee; Carl H June
Costimulatory approaches to adoptive immunotherapy.
Current opinion in oncology 1998;10(6):533-41.
1998: Gary T Brice; J L Riley; Francios VILLINGER; Ann Mayne; Christopher D Hillyer; Carl H June; Aftab A Ansari
Development of an animal model for autotransfusion therapy: in vitro characterization and analysis of anti-CD3/CD28 expanded cells.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;19(3):210-20.
1998: Bruce L Levine; Julio Cotte; C C Small; Richard G Carroll; James L Riley; Wendy B Bernstein; D E Van Epps; R A Hardwick; Carl H June
Large-scale production of CD4+ T cells from HIV-1-infected donors after CD3/CD28 costimulation.
Journal of hematotherapy 1998;7(5):437-48.
1998: James L Riley; Bruce L Levine; Nancy Craighead; T Francomano; D Kim; Richard G Carroll; Carl H June
Naïve and memory CD4 T cells differ in their susceptibilities to human immunodeficiency virus type 1 infection following CD28 costimulation: implicatip6s for transmission and pathogenesis.
Journal of virology 1998;72(10):8273-80.
1998: Richard G Carroll; James L Riley; Bruce L Levine; Patrick J Blair; DC St Louis; Carl H June
The role of co-stimulation in regulation of chemokine receptor expression and HIV-1 infection in primary T lymphocytes.
Seminars in immunology 1998;10(3):195-202.
1998: Thomas A Davis; Abha A Saini; Patrick J Blair; Bruce L Levine; Nancy Craighead; David M Harlan; Carl H June; Kelvin P Lee
Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: evidence for protein kinase C-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3689-97.
1998: J H Horspool; Peter J Perrin; J B Woodcock; J H Cox; C L King; Carl H June; David M Harlan; DC St Louis; Kelvin P Lee
Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):2706-14.
1998: John F McDyer; Theresa J Goletz; E Thomas; Carl H June; Robert A Seder
CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1701-7.
1998: Amy E Lovett-Racke; John L Trotter; Joanne Lauber; Peter J Perrin; Carl H June; Michael K Racke
Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells.
The Journal of clinical investigation 1998;101(4):725-30.
1998: Patrick J Blair; James L Riley; Bruce L Levine; Kelvin P Lee; Nancy Craighead; T Francomano; S J Perfetto; G S Gray; BM Carreno; Carl H June
CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):12-5.
1997: Bruce L Levine; Wendy B Bernstein; M Connors; Nancy Craighead; T Lindsten; CB Thompson; Carl H June
Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5921-30.
1997: Nan-ping Weng; Larry Palmer; Bruce L Levine; H Clifford Lane; Carl H June; Richard J Hodes
Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging.
Immunological reviews 1997;160():43-54.
1997: P Rennert; K Furlong; C Jellis; E Greenfield; G J Freeman; Y Ueda; B Levine; Carl H June; GS Gray
The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion.
International immunology 1997;9(6):805-13.
1997: Bruce L Levine; Wendy B Bernstein; Nancy Craighead; CB Thompson; T Lindsten; DC St Louis; Carl H June
Ex vivo replicative potential of adult human peripheral blood CD4+ T cells.
Transplantation proceedings 1997;29(4):2028.
1997: James L Riley; Richard G Carroll; Bruce L Levine; Wendy B Bernstein; DC St Louis; O S Weislow; Carl H June
Intrinsic resistance to T cell infection with HIV type 1 induced by CD28 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5545-53.
1997: Klaus Pechhold; Noelle B Patterson; Nancy Craighead; Kelvin P Lee; Carl H June; David M Harlan
Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4921-9.
1997: Patrick J Blair; James L Riley; Richard G Carroll; DC St Louis; Bruce L Levine; B Saha; Kelvin P Lee; Peter J Perrin; David M Harlan; Carl H June
CD28 co-receptor signal transduction in T-cell activation.
Biochemical Society transactions 1997;25(2):651-7.
1997: Patrick J Blair; Lawrence Boise; Steven Perfetto; Bruce L Levine; G McCrary; KF Wagner; DC St Louis; CB Thompson; JN Siegel; Carl H June
Impaired induction of the apoptosis-protective protein Bcl-xL in activated PBMC from asymptomatic HIV-infected individuals.
Journal of clinical immunology 1997;17(3):234-46.
1997: Richard G Carroll; James L Riley; Bruce L Levine; Y Feng; S Kaushal; DW Ritchey; Wendy B Bernstein; O S Weislow; C R Brown; E A Berger; Carl H June; DC St Louis
Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells.
Science (New York, N.Y.) 1997;276(5310):273-6.
1997: Larry Palmer; Nan-ping Weng; Bruce L Levine; Carl H June; H Clifford Lane; Richard J Hodes
Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins.
The Journal of experimental medicine 1997;185(7):1381-6.
1997: Peter J Perrin; Thomas A Davis; D S Smoot; R Abe; Carl H June; Kelvin P Lee
Mitogenic stimulation of T cells reveals differing contributions for B7-1 (CD80) and B7-2 (CD86) costimulation.
Immunology 1997;90(4):534-42.
1997: Nan-ping Weng; Bruce L Levine; Carl H June; Richard J Hodes
Regulation of telomerase RNA template expression in human T lymphocyte development and activation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3215-20.
1997: Steven Perfetto; T E Hickey; Patrick J Blair; V C Maino; KF Wagner; S Zhou; DL Mayers; DC St Louis; Carl H June; JN Siegel
Measurement of CD69 induction in the assessment of immune function in asymptomatic HIV-infected individuals.
Cytometry 1997;30(1):1-9.
1996: B Saha; B Jaklic; David M Harlan; G S Gray; Carl H June; R Abe
Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3869-75.
1996: Bruce L Levine; Y Ueda; A Faith; Carl H June
Signal transduction properties of the T cell activation monoclonal antibody panel: ubiquitous increase in cellular substrate tyrosine phosphorylation in the absence of detectable calcium mobilization.
Tissue antigens 1996;48(4 Pt 1):319-24.
1996: Peter J Perrin; J H Maldonado; Thomas A Davis; Carl H June; Michael K Racke
CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1333-6.
1996: Thomas A Davis; Nancy Craighead; A J Williams; A Scadron; Carl H June; Kelvin P Lee
Primary porcine endothelial cells express membrane-bound B7-2 (CD86) and a soluble factor that co-stimulate cyclosporin A-resistant and CD28-dependent human T cell proliferation.
International immunology 1996;8(7):1099-111.
1996: Bruce L Levine; Joseph Mosca; James L Riley; Richard G Carroll; Maryanne Vahey; L L Jagodzinski; K F Wagner; D L Mayers; Donald S. Burke; O S Weislow; DC St Louis; Carl H June
Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation.
Science (New York, N.Y.) 1996;272(5270):1939-43.
1996: B Saha; David M Harlan; Kelvin P Lee; Carl H June; R Abe
Protection against lethal toxic shock by targeted disruption of the CD28 gene.
The Journal of experimental medicine 1996;183(6):2675-80.
1996: Nan-ping Weng; Bruce L Levine; Carl H June; Richard J Hodes
Regulated expression of telomerase activity in human T lymphocyte development and activation.
The Journal of experimental medicine 1996;183(6):2471-9.
1996: T E Hickey; Patrick J Blair; Steven Perfetto; D S Smoot; K F Wagner; DC St Louis; D L Mayers; J N Siegel; Carl H June
Intact antigen receptor-mediated calcium signals in patients with early stage HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(10):4012-7.
1996: Peter J Perrin; D Scott; Thomas A Davis; G S Gray; M J Doggett; R Abe; Carl H June; Michael K Racke
Opposing effects of CTLA4-Ig and anti-CD80 (B7-1) plus anti-CD86 (B7-2) on experimental allergic encephalomyelitis.
Journal of neuroimmunology 1996;65(1):31-9.
1995: Nan-ping Weng; Bruce L Levine; Carl H June; Richard J Hodes
Human naive and memory T lymphocytes differ in telomeric length and replicative potential.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11091-4.
1995: Michael K Racke; D E Scott; Laura Quigley; G S Gray; R Abe; Carl H June; Peter J Perrin
Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.
The Journal of clinical investigation 1995;96(5):2195-203.
1995: Frances T Hakim; R Cepeda; G S Gray; Carl H June; Ryo Abe
Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1757-66.
1995: Lawrence Boise; Andy J Minn; P J Noel; Carl H June; M A Accavitti; T Lindsten; Craig Thompson
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.
Immunity 1995;3(1):87-98.
1995: David M Harlan; M A Barnett; R Abe; K Pechhold; Noelle B Patterson; G S Gray; Carl H June
Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice.
Diabetes 1995;44(7):816-23.
1995: Lawrence Boise; Andy J Minn; Carl H June; T Lindsten; Craig Thompson
Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5491-5.
1995: Y Ueda; Bruce L Levine; M L Huang; Gordon J Freeman; Lee M Nadler; Carl H June; S G Ward
Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion.
International immunology 1995;7(6):957-66.
1995: Bruce L Levine; Y Ueda; Nancy Craighead; M L Huang; Carl H June
CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4+ T cells and induce similar patterns of cytokine secretion in vitro.
International immunology 1995;7(6):891-904.
1995: David M Harlan; R Abe; Kelvin P Lee; Carl H June
Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion.
Clinical immunology and immunopathology 1995;75(2):99-111.
1995: R Abe; P Vandenberghe; Nancy Craighead; D S Smoot; Kelvin P Lee; Carl H June
Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(3):985-97.
1995: Peter J Perrin; D Scott; Laura Quigley; Paul S Albert; O Feder; G S Gray; R Abe; Carl H June; Michael K Racke
Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(3):1481-90.
1995: L A Selvey; Herbert C Morse; Carl H June; Richard J Hodes
Analysis of antigen receptor signaling in B cells from mice with a retrovirus-induced acquired immunodeficiency syndrome.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(1):171-9.
1994: B B Niklinska; D Hou; Carl H June; Allan M Weissman; Jonathan D Ashwell
CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling.
Molecular and cellular biology 1994;14(12):8078-84.
1994: Carl H June; J A Bluestone; Lee M Nadler; Craig Thompson
The B7 and CD28 receptor families.
Immunology today 1994;15(7):321-31.
1994: Carl H June; P Vandenberghe; Craig Thompson
The CD28 and CTLA-4 receptor family.
Chemical immunology 1994;59():62-90.
1993: M C Fletcher; Lawrence E Samelson; Carl H June
Complex effects of phenylarsine oxide in T cells. Induction of tyrosine phosphorylation and calcium mobilization independent of CD45 expression.
The Journal of biological chemistry 1993;268(31):23697-703.
1993: J N Siegel; Carl H June; H Yamada; U R Rapp; Lawrence E Samelson
Rapid activation of C-Raf-1 after stimulation of the T-cell receptor or the muscarinic receptor type 1 in resting T cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):4116-27.
1993: H Yamada; Carl H June; Fred D Finkelman; M Brunswick; M S Ring; Andrew Lees; James J Mond
Persistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA synthesis.
The Journal of experimental medicine 1993;177(6):1613-21.
1993: S Volarević; B B Niklinska; C M Burns; Carl H June; Allan M Weissman; Jonathan D Ashwell
Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains.
Science (New York, N.Y.) 1993;260(5107):541-4.
1993: Carl H June; G P Linette; P F Pierce; N R Jin; Lawrence George Lum
Potential clinical applications of signal transduction measurements in marrow transplantation and HIV-1 infection.
Annals of the New York Academy of Sciences 1993;677():225-32.
1993: Lawrence Boise; B Petryniak; X Mao; Carl H June; C Y Wang; T Lindsten; R Bravo; K Kovary; Jeffrey M Leiden; Craig Thompson
The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.
Molecular and cellular biology 1993;13(3):1911-9.
1992: Gijs A van Seventer; E Bonvini; H Yamada; A Conti; S Stringfellow; Carl H June; S Shaw
Costimulation of T cell receptor/CD3-mediated activation of resting human CD4+ T cells by leukocyte function-associated antigen-1 ligand intercellular cell adhesion molecule-1 involves prolonged inositol phospholipid hydrolysis and sustained increase of intracellular Ca2+ levels.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):3872-80.
1992: J M Green; Laurence A Turka; Carl H June; Craig Thompson
CD28 and staphylococcal enterotoxins synergize to induce MHC-independent T-cell proliferation.
Cellular immunology 1992;145(1):11-20.
1992: Laurence A Turka; M C Fletcher; Nancy Craighead; Craig Thompson; Carl H June
Defective signal transduction by the CD2 molecule in immature T-cell receptor/CD3- thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8706-10.
1992: S Volarević; B B Niklinska; C M Burns; H Yamada; Carl H June; F J Dumont; Jonathan D Ashwell
The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations.
The Journal of experimental medicine 1992;176(3):835-44.
1992: T Nakayama; Y Ueda; H Yamada; E W Shores; Alfred Singer; Carl H June
In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands.
Science (New York, N.Y.) 1992;257(5066):96-9.
1992: Richard B Alexander; E S Bolton; Scott Koenig; G M Jones; Suzanne Topalian; Carl H June; STEVEN ROSENBERG
Detection of antigen specific T lymphocytes by determination of intracellular calcium concentration using flow cytometry.
Journal of immunological methods 1992;148(1-2):131-41.
1992: B B Niklinska; H Yamada; John O'Shea; Carl H June; Jonathan D Ashwell
Tyrosine kinase-regulated and inositol phosphate-independent Ca2+ elevation and mobilization in T cells.
The Journal of biological chemistry 1992;267(10):7154-9.
1992: P Vandenberghe; Gordon J Freeman; Lee M Nadler; M C Fletcher; M Kamoun; Laurence A Turka; J A Ledbetter; Craig Thompson; Carl H June
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.
The Journal of experimental medicine 1992;175(4):951-60.
1992: P R Bohjanen; B Petryniak; Carl H June; Craig Thompson; T Lindsten
AU RNA-binding factors differ in their binding specificities and affinities.
The Journal of biological chemistry 1992;267(9):6302-9.
1992: Craig Thompson; C Y Wang; I C Ho; P R Bohjanen; B Petryniak; Carl H June; Susan Miesfeldt; L Zhang; Gary Nabel; B Karpinski
cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.
Molecular and cellular biology 1992;12(3):1043-53.
1991: M L Lindsberg; M Brunswick; H Yamada; Andrew Lees; J Inman; Carl H June; James J Mond
Biochemical analysis of the immune B cell defect in xid mice.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3774-9.
1991: T Nakayama; Lawrence E Samelson; Y Nakayama; T I Munitz; M Sheard; Carl H June; Alfred Singer
Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):9949-53.
1991: Clifford M Snapper; H Yamada; James J Mond; Carl H June
Cross-linkage of Ly-6A/E induces Ca2+ translocation in the absence of phosphatidylinositol turnover and mediates proliferation of normal murine B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1171-9.
1991: C M Zacharchuk; M Merćep; Carl H June; Allan M Weissman; Jonathan D Ashwell
Variations in thymocyte susceptibility to clonal deletion during ontogeny. Implications for neonatal tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(2):460-5.
1991: P R Bohjanen; B Petryniak; Carl H June; Craig Thompson; T Lindsten
An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.
Molecular and cellular biology 1991;11(6):3288-95.
1991: James J Mond; Nili Feuerstein; Carl H June; A K Balapure; R I Glazer; K Witherspoon; M Brunswick
Bimodal effect of phorbol ester on B cell activation. Implication for the role of protein kinase C.
The Journal of biological chemistry 1991;266(7):4458-63.
1990: ID Horak; M Popovic; E M Horak; P J Lucas; Ronald E Gress; Carl H June; J B Bolen
No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120.
Nature 1990;348(6301):557-60.
1990: S Murakami; K Miyake; Carl H June; P W Kincade; Richard J Hodes
IL-5 induces a Pgp-1 (CD44) bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3618-27.
1990: Carl H June; M C Fletcher; J A Ledbetter; G L Schieven; J N Siegel; A F Phillips; Lawrence E Samelson
Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7722-6.
1990: T Nakayama; Carl H June; T I Munitz; M Sheard; S A McCarthy; Susan O Sharrow; Lawrence E Samelson; Alfred Singer
Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4.
Science (New York, N.Y.) 1990;249(4976):1558-61.
1990: Kelvin P Lee; C Taylor; B Petryniak; Laurence A Turka; Carl H June; Craig Thompson
The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):344-52.
1990: Carl H June; J A Ledbetter; P S Linsley; Craig Thompson
Role of the CD28 receptor in T-cell activation.
Immunology today 1990;11(6):211-6.
1990: Laurence A Turka; J A Ledbetter; K Lee; Carl H June; Craig Thompson
CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1646-53.
1990: George C Tsokos; J D Lambris; Fred D Finkelman; E D Anastassiou; Carl H June
Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1640-5.
1990: Carl H June; M C Fletcher; J A Ledbetter; L E Samelson
Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1591-9.
1990: James J Mond; A Balapure; Nili Feuerstein; Carl H June; M Brunswick; M L Lindsberg; K Witherspoon
Protein kinase C activation in B cells by indolactam inhibits anti-Ig-mediated phosphatidylinositol bisphosphate hydrolysis but not B cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):451-5.
1989: SC Guba; G Stella; Laurence A Turka; Carl H June; Craig Thompson; Stephen G Emerson
Regulation of interleukin 3 gene induction in normal human T cells.
The Journal of clinical investigation 1989;84(6):1701-6.
1989: M Brunswick; Carl H June; Fred D Finkelman; HOWARD DINTZIS; J K Inman; James J Mond
Surface immunoglobulin-mediated B-cell activation in the absence of detectable elevations in intracellular ionized calcium: a model for T-cell-independent B-cell activation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6724-8.
1989: M Brunswick; Carl H June; Fred D Finkelman; James J Mond
Different patterns of inositol polyphosphate production are seen in B lymphocytes after cross-linking of sIg by anti-Ig antibody or by a multivalent anti-Ig antibody dextran conjugate.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1414-21.
1989: G Thyphronitis; George C Tsokos; Carl H June; A D Levine; Fred D Finkelman
IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5580-4.
1989: Carl H June; J A Ledbetter; T Lindsten; Craig Thompson
Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):153-61.
1989: Jeffrey M Leiden; L H Yang; G D Morle; Carl H June; T Lindsten; Craig Thompson; B Karpinski
The 4F2 heavy chain gene: a molecular model of inducible gene expression in human T cells.
Journal of autoimmunity 1989;2 Suppl():67-79.
1989: Carl H June; K M Jackson; J A Ledbetter; Jeffrey M Leiden; T Lindsten; Craig Thompson
Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes.
Journal of autoimmunity 1989;2 Suppl():55-65.
1989: M E Sanders; M W Makgoba; Carl H June; H A Young; S Shaw
Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation.
European journal of immunology 1989;19(5):803-8.
1989: T Lindstein; Carl H June; J A Ledbetter; G Stella; Craig Thompson
Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway.
Science (New York, N.Y.) 1989;244(4902):339-43.
1989: S G Irving; Carl H June; Peter F Zipfel; Ulrich Siebenlist; K Kelly
Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation.
Molecular and cellular biology 1989;9(3):1034-40.
1989: Craig Thompson; T Lindsten; J A Ledbetter; Steven Kunkel; H A Young; Stephen G Emerson; Jeffrey M Leiden; Carl H June
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1333-7.
1988: T Lindsten; Carl H June; Craig Thompson; Jeffrey M Leiden
Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms.
Molecular and cellular biology 1988;8(9):3820-6.
1988: T Lindsten; Carl H June; Craig Thompson
Multiple mechanisms regulate c-myc gene expression during normal T cell activation.
The EMBO journal 1988;7(9):2787-94.
1987: Carl H June; J A Ledbetter; M M Gillespie; T Lindsten; Craig Thompson
T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.
Molecular and cellular biology 1987;7(12):4472-81.