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Harald Jüppner

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Katherine Wesseling-Perry; Harald Jüppner
The osteocyte in CKD: New concepts regarding the role of FGF23 in mineral metabolism and systemic complications.
Jun Guo; F Richard Bringhurst; Henry M Kronenberg; Minlin Liu; Ken-Ichi Miyamoto; Hiroko Segawa; Lige Song; Harald Jüppner
Activation of a Non-cAMP/PKA Signaling Pathway Downstream of the PTH/PTHrP Receptor Is Essential for a Sustained Hypophosphatemic Response to PTH Infusion in Male Mice.
Akira Maeda; Mathew Mahon; Makoto Okazaki; John T Potts; Hiroko Segawa; Abdul B Abou-Samra; David M Baron; Kenneth D Bloch; Thomas Dean; Harald Jüppner; Ashok Khatri; Thomas J Gardella
Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.

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All Publications

2013: Katherine Wesseling-Perry; Harald Jüppner
The osteocyte in CKD: New concepts regarding the role of FGF23 in mineral metabolism and systemic complications.
Bone 2013;54(2):222-9.
2013: Jun Guo; F Richard Bringhurst; Henry M Kronenberg; Minlin Liu; Ken-Ichi Miyamoto; Hiroko Segawa; Lige Song; Harald Jüppner
Activation of a Non-cAMP/PKA Signaling Pathway Downstream of the PTH/PTHrP Receptor Is Essential for a Sustained Hypophosphatemic Response to PTH Infusion in Male Mice.
Endocrinology 2013;154(5):1680-9.
2013: Akira Maeda; Mathew Mahon; Makoto Okazaki; John T Potts; Hiroko Segawa; Abdul B Abou-Samra; David M Baron; Kenneth D Bloch; Thomas Dean; Harald Jüppner; Ashok Khatri; Thomas J Gardella
Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):5864-9.
2013: Marta Christov; Harald Jüppner
Insights from genetic disorders of phosphate homeostasis.
Seminars in nephrology 2013;33(2):143-57.
2013: David E Leaf; Renata C Pereira; Hasan Bazari; Harald Jüppner
Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma.
The Journal of clinical endocrinology and metabolism 2013;98(3):887-91.
2013: Margaret Seton; Harald Jüppner
Autosomal dominant hypophosphatemic rickets in an 85 year old woman: characterization of her disease from infancy through adulthood.
Bone 2013;52(2):640-3.
2012: Harald Jüppner; Myles Wolf
αKlotho: FGF23 coreceptor and FGF23-regulating hormone.
The Journal of clinical investigation 2012;122(12):4336-9.
2012: Serap Turan; Murat Bastepe; Jaakko Ignatius; Outi Kuismin; Agnès Linglart; Nicholas P Mann; Jukka S Moilanen; Helen Stewart; Harald Jüppner
De novo STX16 deletions: an infrequent cause of pseudohypoparathyroidism type Ib that should be excluded in sporadic cases.
The Journal of clinical endocrinology and metabolism 2012;97(12):E2314-9.
2012: Steve Mangos; Jochen Reiser; Ansel P Amaral; Christian Faul; Harald Jüppner; Myles Wolf
Expression of fgf23 and αklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerio.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(12):4314-22.
2012: Michael Mannstadt; Lourdes Mounien; Shohei Sasaki; Hiroko Segawa; Amita Sharma; T Stanley; Bernhard Thorens; Israel Zelikovic; Clemens Bergwitz; Paul Boepple; Daniella Magen; Harald Jüppner
Fanconi-Bickel syndrome and autosomal recessive proximal tubulopathy with hypercalciuria (ARPTH) are allelic variants caused by GLUT2 mutations.
The Journal of clinical endocrinology and metabolism 2012;97(10):E1978-86.
2012: Johanna Korvala; Marika Löija; Outi Mäkitie; Leena Ala-Kokko; William G Cole; Harald Jüppner; Stefano Mora; Dirk Schnabel; Etienne Sochett; Minna Männikkö
Rare variations in WNT3A and DKK1 may predispose carriers to primary osteoporosis.
European journal of medical genetics 2012;55(10):515-9.
2012: Y Yu; N Dunbar; Harald Jüppner; M Reyes; S R Sanderson; A Sharma; T Srivastava; Clemens Bergwitz
Novel NaPi-IIc mutations causing HHRH and idiopathic hypercalciuria in several unrelated families: long-term follow-up in one kindred.
Bone 2012;50(5):1100-6.
2012: Tamara Isakova; Harald Jüppner; Leigh Keating; Kelsey Smith; Nicole Sowden; Allison Barchi-Chung; Gina Collerone; Michael Epstein; Huiliang Xie; Myles Wolf
Daily variability in mineral metabolites in CKD and effects of dietary calcium and calcitriol.
Clinical journal of the American Society of Nephrology : CJASN 2012;7(5):820-8.
2012: Hyon-Seung Yi; Michael Mannstadt; Ie Byung Park; Young Sil Eom; Suntaek Hong; Harald Jüppner; Sangho Lee; Sihoon Lee
Identification and characterization of C106R, a novel mutation in the DNA-binding domain of GCMB, in a family with autosomal-dominant hypoparathyroidism.
Clinical endocrinology 2012;76(5):625-33.
2012: Eduardo Fernández-Rebollo; Leopold F Fröhlich; Harald Jüppner; Gavin Kelsey; Akira Maeda; Antonius Plagge; Monica Reyes; Serap Turan; Murat Bastepe
Loss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6638-43.
2012: Johanna Korvala; Outi Mäkitie; Leena Ala-Kokko; Cynthia F Bartels; William G Cole; Donald Deraska; Heini Hartikka; Harald Jüppner; Stefano Mora; Dirk Schnabel; Etienne Sochett; Matthew L Warman; Minna Männikkö
Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity.
BMC medical genetics 2012;13():26.
2012: Clemens Bergwitz; Harald Jüppner
FGF23 and syndromes of abnormal renal phosphate handling.
Advances in experimental medicine and biology 2012;728():41-64.
2012: Katherine Wesseling-Perry; Ora Yadin; Joshua J Zaritsky; Chi-Hong Tseng; Robert Elashoff; Barbara Gales; Harald Jüppner; Renata C Pereira; Shobha Sahney; Isidro B Salusky
Early skeletal and biochemical alterations in pediatric chronic kidney disease.
Clinical journal of the American Society of Nephrology : CJASN 2012;7(1):146-52.
2011: Katherine Wesseling-Perry; Eileen W Tsai; Robert B Ettenger; Harald Jüppner; Isidro B Salusky
Mineral abnormalities and long-term graft function in pediatric renal transplant recipients: a role for FGF-23?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011;26(11):3779-84.
2011: John P Bilezikian; Maria Luisa Brandi; Bart L Clarke; Michael T Collins; Pierre D'Amour; David Dempster; John Fox; Rachel Gafni; Harald Jüppner; Aliya Khan; Leif Mosekilde; John T Potts; Lars Rejnmark; Mishaela R Rubin; Dolores Shoback; Jim Sliney; James Sanders
Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(10):2317-37.
2011: Svetlana Puzhko; Mohammad Amin Kerachian; Harald Jüppner; Madhusmita Misra; Murat Bastepe; Lucie Canaff; Cynthia Gates Goodyer; Geoffrey N Hendy
Parathyroid hormone signaling via Gαs is selectively inhibited by an NH(2)-terminally truncated Gαs: implications for pseudohypoparathyroidism.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(10):2473-85.
2011: Eduardo Fernández-Rebollo; Emma Anda; Murat Bastepe; Denice Feig; Beatriz Lecumberri; Serena Nik-Zainal; Guiomar Pérez de Nanclares; Gustavo Pérez-Nanclares; Serap Turan; Harald Jüppner
Exclusion of the GNAS locus in PHP-Ib patients with broad GNAS methylation changes: evidence for an autosomal recessive form of PHP-Ib?
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(8):1854-63.
2011: Susanne Thiele; Luisa de Sanctis; Ralf Werner; Joachim Grötzinger; Cumhur Aydin; Harald Jüppner; Murat Bastepe; Olaf Hiort
Functional characterization of GNAS mutations found in patients with pseudohypoparathyroidism type Ic defines a new subgroup of pseudohypoparathyroidism affecting selectively Gsα-receptor interaction.
Human mutation 2011;32(6):653-60.
2011: Harald Jüppner
Phosphate and FGF-23.
Kidney international. Supplement 2011;(121):S24-7.
2011: Clemens Bergwitz; Harald Jüppner
Phosphate sensing.
Advances in chronic kidney disease 2011;18(2):132-44.
2011: Murat Bastepe; Ozge Altug-Teber; Chhavi Agarwal; Sharon E Oberfield; Michael Bonin; Harald Jüppner
Paternal uniparental isodisomy of the entire chromosome 20 as a molecular cause of pseudohypoparathyroidism type Ib (PHP-Ib).
Bone 2011;48(3):659-62.
2011: Anne Marie Sbrocchi; Frank Rauch; Margaret L Lawson; Stasia Hadjiyannakis; Sarah Lawrence; Murat Bastepe; Harald Jüppner; Leanne Marie Ward
Osteosclerosis in two brothers with autosomal dominant pseudohypoparathyroidism type 1b: bone histomorphometric analysis.
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(2):295-301.
2011: Tamara Isakova; Orlando M Gutiérrez; Kelsey Smith; Michael Epstein; Leigh K Keating; Harald Jüppner; Myles Wolf
Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011;26(2):584-91.
2011: So Nagai; Makoto Okazaki; Hiroko Segawa; Clemens Bergwitz; Thomas Dean; John T Potts; Matthew J Mahon; Thomas J Gardella; Harald Jüppner
Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs.
The Journal of biological chemistry 2011;286(2):1618-26.
2011: David L Huso; Harald Jüppner; Michael A. Levine; William Schwindinger; Yingli Wang; Sarah Edie; Emily L Germain-Lee
Heterotopic ossifications in a mouse model of albright hereditary osteodystrophy.
PloS one 2011;6(6):e21755.
2011: Katherine Wesseling-Perry; Renata C Pereira; Shobha Sahney; Barbara Gales; He-Jing Wang; Robert Elashoff; Harald Jüppner; Isidro B Salusky
Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism.
Kidney international 2011;79(1):112-9.
2010: Harald Jüppner; Myles Wolf; Isidro B Salusky
FGF-23: More than a regulator of renal phosphate handling?
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(10):2091-7.
2010: Outi Mäkitie; Renata C Pereira; Ilkka Kaitila; Serap Turan; Murat Bastepe; Timo Laine; Heikki Kröger; William G Cole; Harald Jüppner
Long-term clinical outcome and carrier phenotype in autosomal recessive hypophosphatemia caused by a novel DMP1 mutation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(10):2165-74.
2010: Serap Turan; Leyla Akin; Teoman Akcay; Erdal Adal; Sevil Sarikaya; Murat Bastepe; Harald Jüppner
Recessive versus imprinted disorder: consanguinity can impede establishing the diagnosis of autosomal dominant pseudohypoparathyroidism type Ib.
European journal of endocrinology / European Federation of Endocrine Societies 2010;163(3):489-93.
2010: Smitha Chillambhi; Serap Turan; Daw-Yang Hwang; Hung-Chun Chen; Harald Jüppner; Murat Bastepe
Deletion of the noncoding GNAS antisense transcript causes pseudohypoparathyroidism type Ib and biparental defects of GNAS methylation in cis.
The Journal of clinical endocrinology and metabolism 2010;95(8):3993-4002.
2010: Katherine Wesseling-Perry; G Chris Harkins; He-Jing Wang; Robert Elashoff; Barbara Gales; Mara J Horwitz; Andrew F Stewart; Harald Jüppner; Isidro B Salusky
The calcemic response to continuous parathyroid hormone (PTH)(1-34) infusion in end-stage kidney disease varies according to bone turnover: a potential role for PTH(7-84).
The Journal of clinical endocrinology and metabolism 2010;95(6):2772-80.
2010: Leopold F Fröhlich; Maria Mrakovcic; Ralf Steinborn; Ung-il Chung; Murat Bastepe; Harald Jüppner
Targeted deletion of the Nesp55 DMR defines another Gnas imprinting control region and provides a mouse model of autosomal dominant PHP-Ib.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(20):9275-80.
2010: Takashi Shimada; Itaru Urakawa; Tamara Isakova; Yuji Yamazaki; Michael Epstein; Katherine Wesseling-Perry; Myles Wolf; Isidro B Salusky; Harald Jüppner
Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active.
The Journal of clinical endocrinology and metabolism 2010;95(2):578-85.
2010: Deborah M Mitchell; Harald Jüppner
Regulation of calcium homeostasis and bone metabolism in the fetus and neonate.
Current opinion in endocrinology, diabetes, and obesity 2010;17(1):25-30.
2010: Serap Turan; Cumhur Aydin; Abdullah Bereket; Teoman Akcay; Tülay Güran; Betul Akmen Yaralioglu; Murat Bastepe; Harald Jüppner
Identification of a novel dentin matrix protein-1 (DMP-1) mutation and dental anomalies in a kindred with autosomal recessive hypophosphatemia.
Bone 2010;46(2):402-9.
2010: Clemens Bergwitz; Harald Jüppner
Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23.
Annual review of medicine 2010;61():91-104.
2009: Clemens Bergwitz; Santanu Banerjee; Hilal Abu-Zahra; Hiroshi Kaji; Akimitsu Miyauchi; Toshitsugu Sugimoto; Harald Jüppner
Defective O-glycosylation due to a novel homozygous S129P mutation is associated with lack of fibroblast growth factor 23 secretion and tumoral calcinosis.
The Journal of clinical endocrinology and metabolism 2009;94(11):4267-74.
2009: Dibiyendu Panda; David Goltzman; Harald Jüppner; Andrew C Karaplis
TIP39/parathyroid hormone type 2 receptor signaling is a potent inhibitor of chondrocyte proliferation and differentiation.
American journal of physiology. Endocrinology and metabolism 2009;297(5):E1125-36.
2009: Joel S Finkelstein; Jason J Wyland; Benjamin Z Leder; Sherri-Ann M Burnett-Bowie; Hang Lee; Harald Jüppner; Robert M Neer
Effects of teriparatide retreatment in osteoporotic men and women.
The Journal of clinical endocrinology and metabolism 2009;94(7):2495-501.
2009: Katherine Wesseling-Perry; G Chris Harkins; He-Jing Wang; Shobha Sahney; Barbara Gales; Robert Elashoff; Harald Jüppner; Isidro B Salusky
Response of different PTH assays to therapy with sevelamer or CaCO3 and active vitamin D sterols.
Pediatric nephrology (Berlin, Germany) 2009;24(7):1355-61.
2009: Katherine Wesseling-Perry; Renata C Pereira; Hejing Wang; Robert Elashoff; Shobha Sahney; Barbara Gales; Harald Jüppner; Isidro B Salusky
Relationship between plasma fibroblast growth factor-23 concentration and bone mineralization in children with renal failure on peritoneal dialysis.
The Journal of clinical endocrinology and metabolism 2009;94(2):511-7.
2009: Clemens Bergwitz; Harald Jüppner
Disorders of phosphate homeostasis and tissue mineralisation.
Endocrine development 2009;16():133-56.
2009: Whitney W Brown; Harald Jüppner; Craig B Langman; Heather Price; Emily G Farrow; Kenneth E White; Kenneth L McCormick
Hypophosphatemia with elevations in serum fibroblast growth factor 23 in a child with Jansen's metaphyseal chondrodysplasia.
The Journal of clinical endocrinology and metabolism 2009;94(1):17-20.
2008: Michael Mannstadt; Guylène Bertrand; Mihaela Muresan; Georges Weryha; Bruno Leheup; Sirish R Pulusani; Bernard Grandchamp; Harald Jüppner; Caroline Silve
Dominant-negative GCMB mutations cause an autosomal dominant form of hypoparathyroidism.
The Journal of clinical endocrinology and metabolism 2008;93(9):3568-76.
2008: Orlando Gutierrez; Michael Mannstadt; Tamara Isakova; Jose Alejandro Rauh-Hain; Hector Tamez; Anand Shah; Kelsey Smith; Hang Lee; Ravi Thadhani; Harald Jüppner; Myles Wolf
Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis.
The New England journal of medicine 2008;359(6):584-92.
2008: Graciana Jaureguiberry; Thomas O Carpenter; Stuart Forman; Harald Jüppner; Clemens Bergwitz
A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc.
American journal of physiology. Renal physiology 2008;295(2):F371-9.
2008: Tim M Strom; Harald Jüppner
PHEX, FGF23, DMP1 and beyond.
Current opinion in nephrology and hypertension 2008;17(4):357-62.
2008: Michael Mannstadt; Carol Lorente; Harald Jüppner
Rapid detection of intact FGF-23 in tumor tissue from patients with oncogenic osteomalacia.
Clinical chemistry 2008;54(7):1252-4.
2008: Murat Bastepe; Harald Jüppner
Inherited hypophosphatemic disorders in children and the evolving mechanisms of phosphate regulation.
Reviews in endocrine & metabolic disorders 2008;9(2):171-80.
2007: Agnès Linglart; Murat Bastepe; Harald Jüppner
Similar clinical and laboratory findings in patients with symptomatic autosomal dominant and sporadic pseudohypoparathyroidism type Ib despite different epigenetic changes at the GNAS locus.
Clinical endocrinology 2007;67(6):822-31.
2007: Harald Jüppner
Novel regulators of phosphate homeostasis and bone metabolism.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2007;11 Suppl 1():S3-22.
2007: Guiomar Pérez de Nanclares; Eduardo Fernández-Rebollo; Izortze Santin; Beatriz García-Cuartero; Sonia Gaztambide; Edelmiro Menéndez Torre; Maria Jose Morales; Manuel Pombo; J Ramón Bilbao; Francisco Barros; Nuria Zazo; Wiebke Ahrens; Harald Jüppner; Olaf Hiort; Luis Castaño; Murat Bastepe
Epigenetic defects of GNAS in patients with pseudohypoparathyroidism and mild features of Albright's hereditary osteodystrophy.
The Journal of clinical endocrinology and metabolism 2007;92(6):2370-3.
2007: Leopold F Fröhlich; Murat Bastepe; Defne Ozturk; Hilal Abu-Zahra; Harald Jüppner
Lack of Gnas epigenetic changes and pseudohypoparathyroidism type Ib in mice with targeted disruption of syntaxin-16.
Endocrinology 2007;148(6):2925-35.
2007: Yutong Sun; Jianyun Huang; Yang Xiang; Murat Bastepe; Harald Jüppner; Brian K Kobilka; J. Jue Zhang; Xin-Yun Huang
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR.
The EMBO journal 2007;26(1):53-64.
2006: Santanu Banerjee; selim abdulhafez; Gihan Suliman; Andrew I Geller; Harald Jüppner; F Richard Bringhurst; Paola Divieti
Synthesis and characterization of novel biotinylated carboxyl-terminal parathyroid hormone peptides that specifically crosslink to the CPTH-receptor.
Peptides 2006;27(12):3352-62.
2006: Bettina Lorenz-Depiereux; Murat Bastepe; Anna Benet-Pagès; Mustapha Amyere; Janine Wagenstaller; Ursula Müller-Barth; Klaus Badenhoop; Stephanie M Kaiser; Roger S Rittmaster; Alan H Shlossberg; José L Olivares; César Loris; Feliciano J Ramos; Francis Glorieux; Miikka Vikkula; Harald Jüppner; Tim M Strom
DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.
Nature genetics 2006;38(11):1248-50.
2006: Lihai Zhang; Murat Bastepe; Harald Jüppner; Ke-He Ruan
Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Galphas protein in human coronary artery smooth muscle cells.
Archives of biochemistry and biophysics 2006;454(1):80-8.
2006: I Bhan; A Shah; J Holmes; Tamara Isakova; Orlando Gutierrez; S M Burnett; Harald Jüppner; Myles Wolf
Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'?
Kidney international 2006;70(8):1486-94.
2006: Sherri -Ann M Burnett; Samantha C Gunawardene; F Richard Bringhurst; Harald Jüppner; Hang Lee; Joel S Finkelstein
Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(8):1187-96.
2006: Harald Jüppner; Murat Bastepe
Different mutations within or upstream of the GNAS locus cause distinct forms of pseudohypoparathyroidism.
Journal of pediatric endocrinology & metabolism : JPEM 2006;19 Suppl 2():641-6.
2006: Agnès Linglart; Matthew J Mahon; Mohammad A Kerachian; David M Berlach; Geoffrey N Hendy; Harald Jüppner; Murat Bastepe
Coding GNAS mutations leading to hormone resistance impair in vitro agonist- and cholera toxin-induced adenosine cyclic 3',5'-monophosphate formation mediated by human XLalphas.
Endocrinology 2006;147(5):2253-62.
2006: Harald Jüppner; Agnès Linglart; Leopold F Fröhlich; Murat Bastepe
Autosomal-dominant pseudohypoparathyroidism type Ib is caused by different microdeletions within or upstream of the GNAS locus.
Annals of the New York Academy of Sciences 2006;1068():250-5.
2006: Timothy A Vortherms; Chau H Nguyen; Murat Bastepe; Harald Jüppner; Val Watts
D2 dopamine receptor-induced sensitization of adenylyl cyclase type 1 is G alpha(s) independent.
Neuropharmacology 2006;50(5):576-84.
2006: Thomas Dean; Agnès Linglart; Matthew J Mahon; Murat Bastepe; Harald Jüppner; John T Potts; Thomas J Gardella
Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations.
Molecular endocrinology (Baltimore, Md.) 2006;20(4):931-43.
2006: Caroline Silve; Harald Jüppner
Ollier disease.
Orphanet journal of rare diseases 2006;1():37.
2005: Kevin J Martin; Harald Jüppner; Donald J Sherrard; William G Goodman; Mark R Kaplan; George Nassar; Patricia Campbell; Mario Curzi; Chaim Charytan; Laura C McCary; Matthew D Guo; Stewart A Turner; David A Bushinsky
First- and second-generation immunometric PTH assays during treatment of hyperparathyroidism with cinacalcet HCl.
Kidney international 2005;68(3):1236-43.
2005: Jeffery Fletcher; Min Hu; Yemima Berman; Felicity Collins; John Grigg; Margot McIver; Harald Jüppner; Stephen I Alexander
Multicystic dysplastic kidney and variable phenotype in a family with a novel deletion mutation of PAX2.
Journal of the American Society of Nephrology : JASN 2005;16(9):2754-61.
2005: Isidro B Salusky; William G Goodman; Shobha Sahney; Barbara Gales; Ashley Perilloux; He-Jing Wang; Robert Elashoff; Harald Jüppner
Sevelamer controls parathyroid hormone-induced bone disease as efficiently as calcium carbonate without increasing serum calcium levels during therapy with active vitamin D sterols.
Journal of the American Society of Nephrology : JASN 2005;16(8):2501-8.
2005: Reinhold Erben; Dagmar Mayer; Karin Weber; Kenneth Jonsson; Harald Jüppner; Beate Lanske
Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(7):1149-60.
2005: Orlando Gutierrez; Tamara Isakova; Eugene Rhee; Anand Shah; Julie Holmes; Gina Collerone; Harald Jüppner; Myles Wolf
Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease.
Journal of the American Society of Nephrology : JASN 2005;16(7):2205-15.
2005: Robert C Gensure; Outi Mäkitie; Catherine Barclay; Catherine Chan; Steven R Depalma; Murat Bastepe; Hilal Abuzahra; Richard Couper; Stefan Mundlos; David Sillence; Leena Ala Kokko; Jonathan G Seidman; William G Cole; Harald Jüppner
A novel COL1A1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders.
The Journal of clinical investigation 2005;115(5):1250-7.
2005: Agnès Linglart; Robert C Gensure; Robert C Olney; Harald Jüppner; Murat Bastepe
A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS.
American journal of human genetics 2005;76(5):804-14.
2005: Paola Divieti; Andrew I Geller; G Suliman; Harald Jüppner; F Richard Bringhurst
Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity.
Endocrinology 2005;146(4):1863-70.
2005: Robert C Gensure; Thomas J Gardella; Harald Jüppner
Parathyroid hormone and parathyroid hormone-related peptide, and their receptors.
Biochemical and biophysical research communications 2005;328(3):666-78.
2005: Robert C Gensure; Harald Jüppner
Parathyroid hormone without parathyroid glands.
Endocrinology 2005;146(2):544-6.
2005: Farid H Mahmud; Agnès Linglart; Murat Bastepe; Harald Jüppner; Aida N Lteif
Molecular diagnosis of pseudohypoparathyroidism type Ib in a family with presumed paroxysmal dyskinesia.
Pediatrics 2005;115(2):e242-4.
2005: Takehisa Yamamoto; Yasuo Imanishi; Eiichi Kinoshita; Yoshiko Nakagomi; Nobuhiko Shimizu; Akimitsu Miyauchi; Kenichi Satomura; Hiroyuki Koshiyama; Masaaki Inaba; Yoshiki Nishizawa; Harald Jüppner; Keiichi Ozono
The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome.
Journal of bone and mineral metabolism 2005;23(3):231-7.
2005: Murat Bastepe; Harald Jüppner
GNAS locus and pseudohypoparathyroidism.
Hormone research 2005;63(2):65-74.
2005: Murat Bastepe; Leopold F Fröhlich; Agnès Linglart; Hilal Abu-Zahra; Katsuyoshi Tojo; Leanne M Ward; Harald Jüppner
Deletion of the NESP55 differentially methylated region causes loss of maternal GNAS imprints and pseudohypoparathyroidism type Ib.
Nature genetics 2005;37(1):25-7.
2004: Elena Laspa; Murat Bastepe; Harald Jüppner; Agathocles Tsatsoulis
Phenotypic and molecular genetic aspects of pseudohypoparathyroidism type Ib in a Greek kindred: evidence for enhanced uric acid excretion due to parathyroid hormone resistance.
The Journal of clinical endocrinology and metabolism 2004;89(12):5942-7.
2004: Despina Sitara; Mohammed S Razzaque; Martina Hesse; Subbiah Yoganathan; Takashi Taguchi; Reinhold Erben; Harald Jüppner; Beate Lanske
Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice.
Matrix biology : journal of the International Society for Matrix Biology 2004;23(7):421-32.
2004: Madhusudhan R Papasani; Robert C Gensure; Yi-Lin Yan; Yasemin Gunes; John H Postlethwait; Bhaskar Ponugoti; Markus R John; Harald Jüppner; David A Rubin
Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39.
Endocrinology 2004;145(11):5294-304.
2004: Murat Bastepe; Lee S Weinstein; Naoshi Ogata; Hiroshi Kawaguchi; Harald Jüppner; Henry M Kronenberg; Ung-il Chung
Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14794-9.
2004: Leopold F Fröhlich; Robert C Gensure; Ernestina Schipani; Harald Jüppner; Murat Bastepe
Haplotype frequencies and linkage disequilibrium analysis of four frequent polymorphisms at the PTH/PTH-related peptide receptor gene locus.
Molecular and cellular probes 2004;18(5):353-7.
2004: Murat Bastepe; Annick Raas-Rothschild; Justin Silver; Irit Weissman; Shlomo Wientroub; Harald Jüppner; David Gillis
A form of Jansen's metaphyseal chondrodysplasia with limited metabolic and skeletal abnormalities is caused by a novel activating parathyroid hormone (PTH)/PTH-related peptide receptor mutation.
The Journal of clinical endocrinology and metabolism 2004;89(7):3595-600.
2004: Isidro B Salusky; Harald Jüppner
New PTH assays and renal osteodystrophy.
Pediatric nephrology (Berlin, Germany) 2004;19(7):709-13.
2004: Tobias Larsson; Richard Marsell; Ernestina Schipani; Claes Ohlsson; Osten Ljunggren; Harriet S Tenenhouse; Harald Jüppner; Kenneth B Jonsson
Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis.
Endocrinology 2004;145(7):3087-94.
2004: Robert C Gensure; Bhaskar Ponugoti; Yasemin Gunes; Madhusudhan R Papasani; Beate Lanske; Murat Bastepe; David A Rubin; Harald Jüppner
Identification and characterization of two parathyroid hormone-like molecules in zebrafish.
Endocrinology 2004;145(4):1634-9.
2004: Isidro B Salusky; Beatriz G Kuizon; Harald Jüppner
Special aspects of renal osteodystrophy in children.
Seminars in nephrology 2004;24(1):69-77.
2003: Tobias Larsson; Ulf Nisbeth; Osten Ljunggren; Harald Jüppner; Kenneth B Jonsson
Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers.
Kidney international 2003;64(6):2272-9.
2003: Murat Bastepe; Leopold F Fröhlich; Geoffrey N Hendy; Olafur S Indridason; Robert G Josse; Hiroyuki Koshiyama; Jarmo Körkkö; Jon M Nakamoto; Arlan Rosenbloom; Arnold H Slyper; Toshitsugu Sugimoto; Agathocles Tsatsoulis; John D Crawford; Harald Jüppner
Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS.
The Journal of clinical investigation 2003;112(8):1255-63.
2003: Anne E Nelson; Roderick Clifton Bligh; Michiko Mirams; Anthony Gill; Amy Au; Adele Clarkson; Harald Jüppner; Stephen Ruff; Paul Stalley; Richard A Scolyer; Bruce G Robinson; Rebecca S Mason; Phillip Clifton Bligh
Clinical case seminar: Fibroblast growth factor 23: a new clinical marker for oncogenic osteomalacia.
The Journal of clinical endocrinology and metabolism 2003;88(9):4088-94.
2003: Murat Bastepe; Harald Jüppner
Editorial: Pseudohypoparathyroidism and mechanisms of resistance toward multiple hormones: molecular evidence to clinical presentation.
The Journal of clinical endocrinology and metabolism 2003;88(9):4055-8.
2003: Isidro B Salusky; William G Goodman; Beatriz D Kuizon; Jeffrey R Lavigne; Richard J Zahranik; Barbara Gales; He-Jing Wang; Robert Elashoff; Harald Jüppner
Similar predictive value of bone turnover using first- and second-generation immunometric PTH assays in pediatric patients treated with peritoneal dialysis.
Kidney international 2003;63(5):1801-8.
2003: Kenneth B Jonsson; Richard Zahradnik; Tobias Larsson; Kenneth E White; Toshitsugu Sugimoto; Yasuo Imanishi; Takehisa Yamamoto; Geeta Hampson; Hiroyuki Koshiyama; Osten Ljunggren; Koichi Oba; In Myung Yang; Akimitsu Miyauchi; Michael J Econs; Jeffrey Lavigne; Harald Jüppner
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia.
The New England journal of medicine 2003;348(17):1656-63.
2003: Tobias Larsson; Richard Zahradnik; Jeffrey Lavigne; Osten Ljunggren; Harald Jüppner; Kenneth B Jonsson
Immunohistochemical detection of FGF-23 protein in tumors that cause oncogenic osteomalacia.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(2):269-76.
2003: William G Goodman; Harald Jüppner; Isidro B Salusky; Donald J Sherrard
Parathyroid hormone (PTH), PTH-derived peptides, and new PTH assays in renal osteodystrophy.
Kidney international 2003;63(1):1-11.
2002: Harald Jüppner; John T Potts
Immunoassays for the detection of parathyroid hormone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17 Suppl 2():N81-6.
2002: William G Goodman; Isidro B Salusky; Harald Jüppner
New lessons from old assays: parathyroid hormone (PTH), its receptors, and the potential biological relevance of PTH fragments.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17(10):1731-6.
2002: Murat Bastepe; Yasemin Gunes; Beatriz Perez-Villamil; Joy Hunzelman; Lee S Weinstein; Harald Jüppner
Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1912-9.
2002: Markus R John; Maya Arai; David A Rubin; Kenneth B Jonsson; Harald Jüppner
Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.
Endocrinology 2002;143(3):1047-57.
2002: Sevan Hopyan; Nalan Gokgoz; Raymond Poon; Robert C Gensure; Chunying Yu; William G Cole; Robert S Bell; Harald Jüppner; Irene L Andrulis; Jay S Wunder; Benjamin A Alman
A mutant PTH/PTHrP type I receptor in enchondromatosis.
Nature genetics 2002;30(3):306-10.
2002: Harald Jüppner
The genetic basis of progressive osseous heteroplasia.
The New England journal of medicine 2002;346(2):128-30.
2002: Paola Divieti; Markus R John; Harald Jüppner; F Richard Bringhurst
Human PTH-(7-84) inhibits bone resorption in vitro via actions independent of the type 1 PTH/PTHrP receptor.
Endocrinology 2002;143(1):171-6.
2001: Robert C Gensure; Percy H Carter; Brian D Petroni; Harald Jüppner; Thomas J Gardella
Identification of determinants of inverse agonism in a constitutively active parathyroid hormone/parathyroid hormone-related peptide receptor by photoaffinity cross-linking and mutational analysis.
The Journal of biological chemistry 2001;276(46):42692-9.
2001: Robert C Gensure; Thomas J Gardella; Harald Jüppner
Multiple sites of contact between the carboxyl-terminal binding domain of PTHrP-(1--36) analogs and the amino-terminal extracellular domain of the PTH/PTHrP receptor identified by photoaffinity cross-linking.
The Journal of biological chemistry 2001;276(31):28650-8.
2001: Thomas J Gardella; Harald Jüppner
Molecular properties of the PTH/PTHrP receptor.
Trends in endocrinology and metabolism: TEM 2001;12(5):210-7.
2001: Murat Bastepe; JE Pincus; Toshitsugu Sugimoto; K Tojo; M Kanatani; Y Azuma; K Kruse; Arlan Rosenbloom; Hiroyuki Koshiyama; Harald Jüppner
Positional dissociation between the genetic mutation responsible for pseudohypoparathyroidism type Ib and the associated methylation defect at exon A/B: evidence for a long-range regulatory element within the imprinted GNAS1 locus.
Human molecular genetics 2001;10(12):1231-41.
2001: Kenneth B Jonsson; M Mannstadt; Akimitsu Miyauchi; In Myung Yang; G Stein; Harald Jüppner
Extracts from tumors causing oncogenic osteomalacia inhibit phosphate uptake in opossum kidney cells.
The Journal of endocrinology 2001;169(3):613-20.
2001: Murat Bastepe; Andrew lane; Harald Jüppner
Paternal uniparental isodisomy of chromosome 20q--and the resulting changes in GNAS1 methylation--as a plausible cause of pseudohypoparathyroidism.
American journal of human genetics 2001;68(5):1283-9.
2001: Paola Divieti; N Inomata; K Chapin; R Singh; Harald Jüppner; F Richard Bringhurst
Receptors for the carboxyl-terminal region of pth(1-84) are highly expressed in osteocytic cells.
Endocrinology 2001;142(2):916-25.
2001: Kenneth B Jonsson; Markus R John; Robert C Gensure; Thomas J Gardella; Harald Jüppner
Tuberoinfundibular peptide 39 binds to the parathyroid hormone (PTH)/PTH-related peptide receptor, but functions as an antagonist.
Endocrinology 2001;142(2):704-9.
2001: Kenneth E White; Kenneth B Jonsson; Gwenaelle Carn; G Hampson; T D Spector; M Mannstadt; Bettina Lorenz-Depiereux; Akimitsu Miyauchi; In Myung Yang; Osten Ljunggren; Thomas Meitinger; Tim M Strom; Harald Jüppner; Michael J Econs
The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting.
The Journal of clinical endocrinology and metabolism 2001;86(2):497-500.
2000: Thomas J Gardella; Harald Jüppner
Interaction of PTH and PTHrP with their receptors.
Reviews in endocrine & metabolic disorders 2000;1(4):317-29.
2000: Murat Bastepe; Harald Jüppner
Pseudohypoparathyroidism. New insights into an old disease.
Endocrinology and metabolism clinics of North America 2000;29(3):569-89.
2000: Murat Bastepe; Harald Jüppner
Identification and characterization of two new, highly polymorphic loci adjacent to GNAS1 on chromosome 20q13.3.
Molecular and cellular probes 2000;14(4):261-4.
2000: Harald Jüppner
Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.
Pediatric nephrology (Berlin, Germany) 2000;14(7):606-11.
2000: Cheryl P Sanchez; Beatriz D Kuizon; P A Abdella; Harald Jüppner; Isidro B Salusky; William G Goodman
Impaired growth, delayed ossification, and reduced osteoclastic activity in the growth plate of calcium-supplemented rats with renal failure.
Endocrinology 2000;141(4):1536-44.
1999: Murat Bastepe; JE Pincus; Harald Jüppner
Two frequent tetra-nucleotide repeat polymorphisms between VAPB and STX16 on chromosome 20q13.
Molecular and cellular probes 1999;13(6):449-51.
1999: Markus R John; W G Goodman; Ping Gao; Tom Cantor; I B Salusky; Harald Jüppner
A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure.
The Journal of clinical endocrinology and metabolism 1999;84(11):4287-90.
1999: M Mannstadt; Harald Jüppner; Thomas J Gardella
Receptors for PTH and PTHrP: their biological importance and functional properties.
The American journal of physiology 1999;277(5 Pt 2):F665-75.
1999: Percy H Carter; Harald Jüppner; Thomas J Gardella
Studies of the N-terminal region of a parathyroid hormone-related peptide (1-36) analog: receptor subtype-selective agonists, antagonists, and photochemical cross-linking agents.
Endocrinology 1999;140(11):4972-81.
1999: David A Rubin; Harald Jüppner
Zebrafish express the common parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) and a novel receptor (PTH3R) that is preferentially activated by mammalian and fugufish parathyroid hormone-related peptide.
The Journal of biological chemistry 1999;274(40):28185-90.
1999: Ernestina Schipani; C Langman; Joy Hunzelman; M Le Merrer; K Y Loke; M J Dillon; C Silve; Harald Jüppner
A novel parathyroid hormone (PTH)/PTH-related peptide receptor mutation in Jansen's metaphyseal chondrodysplasia.
The Journal of clinical endocrinology and metabolism 1999;84(9):3052-7.
1999: David A Rubin; P Hellman; Leonard I Zon; C J Lobb; Clemens Bergwitz; Harald Jüppner
A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones.
The Journal of biological chemistry 1999;274(33):23035-42.
1999: Harald Jüppner
Receptors for parathyroid hormone and parathyroid hormone-related peptide: exploration of their biological importance.
Bone 1999;25(1):87-90.
1998: Cheryl P Sanchez; Isidro B Salusky; Beatriz D Kuizon; P Abdella; Harald Jüppner; William G Goodman
Growth of long bones in renal failure: roles of hyperparathyroidism, growth hormone and calcitriol.
Kidney international 1998;54(6):1879-87.
1998: Harald Jüppner; Ernestina Schipani; Murat Bastepe; D E Cole; M L Lawson; M Mannstadt; Geoffrey N Hendy; Horacio Plotkin; Hiroyuki Koshiyama; T Koh; J D Crawford; Bjorn R Olsen; Miikka Vikkula
The gene responsible for pseudohypoparathyroidism type Ib is paternally imprinted and maps in four unrelated kindreds to chromosome 20q13.3.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11798-803.
1998: M Mannstadt; MD Luck; Thomas J Gardella; Harald Jüppner
Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies.
The Journal of biological chemistry 1998;273(27):16890-6.
1998: Clemens Bergwitz; P Klein; H Kohno; Stuart A Forman; Kaechoong Lee; D Rubin; Harald Jüppner
Identification, functional characterization, and developmental expression of two nonallelic parathyroid hormone (PTH)/PTH-related peptide receptor isoforms in Xenopus laevis (Daudin).
Endocrinology 1998;139(2):723-32.
1998: Henry M Kronenberg; Beate Lanske; CS Kovacs; Ung-il Chung; Kaechoong Lee; Gino V Segre; Ernestina Schipani; Harald Jüppner
Functional analysis of the PTH/PTHrP network of ligands and receptors.
Recent progress in hormone research 1998;53():283-301; discussion 301-3.
1998: Beatriz D Kuizon; William G Goodman; Harald Jüppner; I Boechat; P Nelson; Barbara Gales; Isidro B Salusky
Diminished linear growth during intermittent calcitriol therapy in children undergoing CCPD.
Kidney international 1998;53(1):205-11.
1997: Ernestina Schipani; Beate Lanske; Joy Hunzelman; A Luz; CS Kovacs; Kaechoong Lee; AE Pirro; Henry M Kronenberg; Harald Jüppner
Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13689-94.
1997: Clemens Bergwitz; S A Jusseaume; MD Luck; Harald Jüppner; Thomas J Gardella
Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide.
The Journal of biological chemistry 1997;272(46):28861-8.
1997: John T Potts; Thomas J Gardella; Harald Jüppner; Henry M Kronenberg
Structure based design of parathyroid hormone analogs.
The Journal of endocrinology 1997;154 Suppl():S15-21.
1997: Ernestina Schipani; G S Jensen; JE Pincus; R A Nissenson; Thomas J Gardella; Harald Jüppner
Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia.
Molecular endocrinology (Baltimore, Md.) 1997;11(7):851-8.
1997: YC Li; Clemens Bergwitz; Harald Jüppner; Marie B Demay
Cloning and characterization of the vitamin D receptor from Xenopus laevis.
Endocrinology 1997;138(6):2347-53.
1997: John T Potts; Thomas J Gardella; Harald Jüppner; Henry M Kronenberg
The history of parathyroid hormone and its receptor: structure-based design of parathyroid hormone analogues.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1997;7 Suppl 3():S169-73.
1996: Clemens Bergwitz; Thomas J Gardella; M R Flannery; John T Potts; Henry M Kronenberg; Steven R Goldring; Harald Jüppner
Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction.
The Journal of biological chemistry 1996;271(43):26469-72.
1996: Ernestina Schipani; C B Langman; A Michael Parfitt; G S Jensen; S Kikuchi; S W Kooh; W G Cole; Harald Jüppner
Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia.
The New England journal of medicine 1996;335(10):708-14.
1996: Thomas J Gardella; MD Luck; G S Jensen; Ernestina Schipani; John T Potts; Harald Jüppner
Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors.
Endocrinology 1996;137(9):3936-41.
1996: Thomas J Gardella; MD Luck; G S Jensen; T B Usdin; Harald Jüppner
Converting parathyroid hormone-related peptide (PTHrP) into a potent PTH-2 receptor agonist.
The Journal of biological chemistry 1996;271(33):19888-93.
1996: Beate Lanske; A C Karaplis; Kaechoong Lee; A Luz; A Vortkamp; AE Pirro; Marcel Karperien; Libert H K Defize; C Ho; R C Mulligan; Abdul B Abou-Samra; Harald Jüppner; Gino V Segre; Henry M Kronenberg
PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.
Science (New York, N.Y.) 1996;273(5275):663-6.
1996: Harald Jüppner
Jansen's metaphyseal chondrodysplasia: a disorder due to a PTH/PTHrP receptor gene mutation.
Trends in endocrinology and metabolism: TEM 1996;7(5):157-62.
1996: Harald Jüppner; Ernestina Schipani
Receptors for parathyroid hormone and parathyroid hormone-related peptide: from molecular cloning to definition of diseases.
Current opinion in nephrology and hypertension 1996;5(4):300-6.
1995: N Inomata; M Akiyama; N Kubota; Harald Jüppner
Characterization of a novel parathyroid hormone (PTH) receptor with specificity for the carboxyl-terminal region of PTH-(1-84)
Endocrinology 1995;136(11):4732-40.
1995: C Lee; MD Luck; Harald Jüppner; John T Potts; Henry M Kronenberg; Thomas J Gardella
Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop.
Molecular endocrinology (Baltimore, Md.) 1995;9(10):1269-78.
1995: Harald Jüppner
Functional properties of the PTH/PTHrP receptor.
Bone 1995;17(2 Suppl):39S-42S.
1995: J J Orloff; Y Kats; P Urena; Ernestina Schipani; Rupangi C Vasavada; William M Philbrick; A Behal; Abdul B Abou-Samra; Gino V Segre; Harald Jüppner
Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines.
Endocrinology 1995;136(7):3016-23.
1995: A Iida-Klein; Jun Guo; L Y Xie; Harald Jüppner; John T Potts; Henry M Kronenberg; F Richard Bringhurst; Abdul B Abou-Samra; Gino V Segre
Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C.
The Journal of biological chemistry 1995;270(15):8458-65.
1995: Ernestina Schipani; K Kruse; Harald Jüppner
A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia.
Science (New York, N.Y.) 1995;268(5207):98-100.
1994: Abdul B Abou-Samra; P K Goldsmith; L Y Xie; Harald Jüppner; Allen Spiegel; Gino V Segre
Down-regulation of parathyroid (PTH)/PTH-related peptide receptor immunoreactivity and PTH binding in opossum kidney cells by PTH and dexamethasone.
Endocrinology 1994;135(6):2588-94.
1994: C Lee; Thomas J Gardella; Abdul B Abou-Samra; S R Nussbaum; Gino V Segre; John T Potts; Henry M Kronenberg; Harald Jüppner
Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding.
Endocrinology 1994;135(4):1488-95.
1994: Thomas J Gardella; Harald Jüppner; A K Wilson; H T Keutmann; Abdul B Abou-Samra; Gino V Segre; F Richard Bringhurst; John T Potts; S R Nussbaum; Henry M Kronenberg
Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor.
Endocrinology 1994;135(3):1186-94.
1994: Clemens Bergwitz; Abdul B Abou-Samra; R D Hesch; Harald Jüppner
Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2).
Biochimica et biophysica acta 1994;1222(3):447-56.
1994: Harald Jüppner
Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors.
Current opinion in nephrology and hypertension 1994;3(4):371-8.
1994: Ernestina Schipani; F G Hustmyer; Clemens Bergwitz; Harald Jüppner
Polymorphism in exon M7 of the PTHR gene.
Human molecular genetics 1994;3(7):1210.
1994: X F Kong; Ernestina Schipani; Beate Lanske; H Joun; Marcel Karperien; Libert H K Defize; Harald Jüppner; John T Potts; Gino V Segre; Henry M Kronenberg
The rat, mouse, and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous.
Biochemical and biophysical research communications 1994;201(2):1058.
1994: X F Kong; Ernestina Schipani; Beate Lanske; H Joun; Marcel Karperien; Libert H K Defize; Harald Jüppner; John T Potts; Gino V Segre; Henry M Kronenberg
The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous.
Biochemical and biophysical research communications 1994;200(3):1290-9.
1994: S Fukayama; Ernestina Schipani; Harald Jüppner; Beate Lanske; Henry M Kronenberg; Abdul B Abou-Samra; F Richard Bringhurst
Role of protein kinase-A in homologous down-regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells.
Endocrinology 1994;134(4):1851-8.
1994: Harald Jüppner; Ernestina Schipani; F Richard Bringhurst; I McClure; H T Keutmann; John T Potts; Henry M Kronenberg; Abdul B Abou-Samra; Gino V Segre; Thomas J Gardella
The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34).
Endocrinology 1994;134(2):879-84.
1994: Pablo Ureña; A Iida-Klein; X F Kong; Harald Jüppner; Henry M Kronenberg; Abdul B Abou-Samra; Gino V Segre
Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells.
Endocrinology 1994;134(1):451-6.
1994: Abdul B Abou-Samra; Harald Jüppner; X F Kong; Ernestina Schipani; A Iida-Klein; H Karga; P Urena; T F Gardella; John T Potts; Henry M Kronenberg
Structure, function, and expression of the receptor for parathyroid hormone and parathyroid hormone-related peptide.
Advances in nephrology from the Necker Hospital 1994;23():247-64.
1994: Pablo Ureña; Abdul B Abou-Samra; Harald Jüppner; X F Kong; Kaechoong Lee; F Richard Bringhurst; Gino V Segre
[Mode of action of parathyroid hormone (PTH) and PTH-related peptide (PTHrP) in target organs].
Annales d'endocrinologie 1994;55(5):133-41.
1993: Pablo Ureña; X F Kong; Abdul B Abou-Samra; Harald Jüppner; Henry M Kronenberg; John T Potts; Gino V Segre
Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues.
Endocrinology 1993;133(2):617-23.
1993: Kaechoong Lee; J D Deeds; Andrew Bond; Harald Jüppner; Abdul B Abou-Samra; Gino V Segre
In situ localization of PTH/PTHrP receptor mRNA in the bone of fetal and young rats.
Bone 1993;14(3):341-5.
1993: Ernestina Schipani; H Karga; A C Karaplis; John T Potts; Henry M Kronenberg; Gino V Segre; Abdul B Abou-Samra; Harald Jüppner
Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor.
Endocrinology 1993;132(5):2157-65.
1993: Abdul B Abou-Samra; Harald Jüppner; A Khalifa; H Karga; X F Kong; D Schiffer-Alberts; L Y Xie; Gino V Segre
Parathyroid hormone (PTH) stimulates adrenocorticotropin release in AtT-20 cells stably expressing a common receptor for PTH and PTH-related peptide.
Endocrinology 1993;132(2):801-5.
1993: A van de Stolpe; Marcel Karperien; Clemens W G M Löwik; Harald Jüppner; Gino V Segre; Abdul B Abou-Samra; SW De Laat; Libert H K Defize
Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation.
The Journal of cell biology 1993;120(1):235-43.
1992: S Uneno; T Yamamuro; Harald Jüppner; Abdul B Abou-Samra; H T Keutmann; John T Potts; Gino V Segre
Solubilization of functional receptors for parathyroid hormone and parathyroid hormone-related peptide from clonal rat osteosarcoma cells, ROS17/2.8.
Calcified tissue international 1992;51(5):382-6.
1992: Abdul B Abou-Samra; Harald Jüppner; Thomas Force; Mason W Freeman; X F Kong; Ernestina Schipani; P Urena; J Richards; Joseph V Bonventre; John T Potts
Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2732-6.
1992: Gino V Segre; Abdul B Abou-Samra; Harald Jüppner; Ernestina Schipani; Thomas Force; P Urena; M Freeman; X F Kong; L F Kolakowski; Janet Hock
Characterization of cloned PTH/PTHrP receptors.
Journal of endocrinological investigation 1992;15(9 Suppl 6):11-7.
1991: Harald Jüppner; Abdul B Abou-Samra; M Freeman; X F Kong; Ernestina Schipani; J Richards; L F Kolakowski; Janet Hock; John T Potts; Henry M Kronenberg
A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.
Science (New York, N.Y.) 1991;254(5034):1024-6.
1991: Clemens Bergwitz; S Madoff; Abdul B Abou-Samra; Harald Jüppner
Specific, high-affinity binding sites for angiotensin II on Mycoplasma hyorhinis.
Biochemical and biophysical research communications 1991;179(3):1391-9.
1990: Harald Jüppner; Abdul B Abou-Samra; S Uneno; Ernestina Schipani; H T Keutmann; John T Potts; Gino V Segre
Properties of amino-terminal parathyroid hormone-related peptides modified at positions 11-13.
Peptides 1990;11(6):1139-42.
1990: Harald Jüppner; Abdul B Abou-Samra; S Uneno; H T Keutmann; John T Potts; Gino V Segre
Preparation and characterization of [N alpha-(4-azido-2-nitrophenyl)Ala1,Tyr36]-parathyroid hormone related peptide (1-36)amide: a high-affinity, partial agonist having high cross-linking efficiency with its receptor on ROS 17/2.8 cells.
Biochemistry 1990;29(30):6941-6.
1990: Abdul B Abou-Samra; M Freeman; Harald Jüppner; S Uneno; Gino V Segre
Characterization of fully active biotinylated parathyroid hormone analogs. Application to fluorescence-activated cell sorting of parathyroid hormone receptor bearing cells.
The Journal of biological chemistry 1990;265(1):58-62.
1988: Harald Jüppner; Abdul B Abou-Samra; S Uneno; W X Gu; John T Potts; Gino V Segre
The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.
The Journal of biological chemistry 1988;263(18):8557-60.