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Seppo Kaakkola
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12
Jääskeläinen, Iiro
12
Männistö, Pekka
12
Pekkonen, Eero
11
Huttunen, Juha
10
Ahveninen, Jyrki
9
Teräväinen, Heikki
8
Gordin, Ariel
6
Kähkönen, Seppo
5
Wurtman, Richard
4
Lyytinen, Jukka
4
Palo, Jukka
4
Ilmoniemi, Risto
3
Hirvonen, Jyrki
3
Tiitinen, Hannu
2
Udd, Bjarne
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Geonetwork of Seppo Kaakkola (preview)
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All Publications
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2009: Kuoppamäki Mikko; Korpela Kirsi; Marttila Reijo; Kaasinen Valtteri; Hartikainen Päivi; Lyytinen Jukka; Kaakkola Seppo; Hänninen Jutta; Löyttyniemi Eliisa; Kailajärvi Marita; Ruokoniemi Päivi; Ellmén Juha
Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily.
European journal of clinical pharmacology 2009;65(5):443-55.
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2007: Kaakkola Seppo
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(18):2189.
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2006: Myllylä V; Haapaniemi T; Kaakkola S; Kinnunen E; Hartikainen P; Nuutinen J; Rissanen A; Kuopio A M; Jolma T; Satomaa O; Heikkinen H
Patient satisfaction with switching to Stalevo: an open-label evaluation in PD patients experiencing wearing-off (Simcom Study).
Acta neurologica Scandinavica 2006;114(3):181-6.
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2006: Marttila Reijo; Heikkinen Esa; Hänninen Jouko; Jousilahti Pekka; Jäättelä Antti; Kaakkola Seppo; Keränen Tapani; Sotaniemi Kyösti; Teräväinen Heikki
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2006;122(21):2655-6.
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2005: Hakonen Anna H; Heiskanen Silja; Juvonen Vesa; Lappalainen Ilse; Luoma Petri T; Rantamaki Maria; Goethem Gert Van; Lofgren Ann; Hackman Peter; Paetau Anders; Kaakkola Seppo; Majamaa Kari; Varilo Teppo; Udd Bjarne; Kaariainen Helena; Bindoff Laurence A; Suomalainen Anu
Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin.
American journal of human genetics 2005;77(3):430-41.
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2005: Pekkonen Eero; Jääskeläinen Iiro P; Kaakkola Seppo; Ahveninen Jyrki
Cholinergic modulation of preattentive auditory processing in aging.
NeuroImage 2005;27(2):387-92.
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2005: Janhunen Sanna; Mielikäinen Paula; Paldánius Päivi; Tuominen Raimo K; Ahtee Liisa; Kaakkola Seppo
The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats.
Naunyn-Schmiedeberg's archives of pharmacology 2005;371(6):480-91.
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2005: Lyytinen Jukka; Kaakkola Seppo
[Will the mystery of Parkinson's disease be resolved?]
Duodecim; lääketieteellinen aikakauskirja 2005;121(3):275-84.
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2004: Van Goethem G; Luoma P; Rantamäki M; Al Memar A; Kaakkola S; Hackman P; Krahe R; Löfgren A; Martin J J; De Jonghe P; Suomalainen A; Udd B; Van Broeckhoven C
POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement.
Neurology 2004;63(7):1251-7.
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2004: Gordin A; Kaakkola S; Teräväinen H
Clinical advantages of COMT inhibition with entacapone - a review.
Journal of neural transmission (Vienna, Austria : 1996) 2004;111(10-11):1343-63.
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2003: Osipova Daria; Ahveninen Jyrki; Kaakkola Seppo; Jääskeläinen Iiro P; Huttunen Juha; Pekkonen Eero
Effects of scopolamine on MEG spectral power and coherence in elderly subjects.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2003;114(10):1902-7.
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2003: Huttunen Juha; Kähkönen Seppo; Kaakkola Seppo; Ahveninen Jyrki; Pekkonen Eero
Effects of an acute D2-dopaminergic blockade on the somatosensory cortical responses in healthy humans: evidence from evoked magnetic fields.
Neuroreport 2003;14(12):1609-12.
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2003: Keränen T; Kaakkola S; Sotaniemi K; Laulumaa V; Haapaniemi T; Jolma T; Kola H; Ylikoski A; Satomaa O; Kovanen J; Taimela E; Haapaniemi H; Turunen H; Takala A
Economic burden and quality of life impairment increase with severity of PD.
Parkinsonism & related disorders 2003;9(3):163-8.
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2003: Gordin Ariel; Kaakkola Seppo; Teräväinen Heikki
Position of COMT inhibition in the treatment of Parkinson's disease.
Advances in neurology 2003;91():237-50.
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2002: Kähkönen Seppo; Ahveninen Jyrki; Pekkonen Eero; Kaakkola Seppo; Huttunen Juha; Ilmoniemi Risto J; Jääskeläinen Iiro P
Dopamine modulates involuntary attention shifting and reorienting: an electromagnetic study.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2002;113(12):1894-902.
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2002: Heikkinen Helena; Varhe Anu; Laine Tarmo; Puttonen Jaakko; Kela Marjo; Kaakkola Seppo; Reinikainen Kari
Entacapone improves the availability of L-dopa in plasma by decreasing its peripheral metabolism independent of L-dopa/carbidopa dose.
British journal of clinical pharmacology 2002;54(4):363-71.
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2002: Lyytinen J; Kaakkola S; Gordin A; Kultalahti E-R; Teräväinen H; Sovijärvi A
The effect of COMT inhibition with entacapone on cardiorespiratory responses to exercise in patients with Parkinson's disease.
Parkinsonism & related disorders 2002;8(5):349-55.
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2002: Salenius Stephan; Avikainen Sari; Kaakkola Seppo; Hari Riitta; Brown Peter
Defective cortical drive to muscle in Parkinson's disease and its improvement with levodopa.
Brain : a journal of neurology 2002;125(Pt 3):491-500.
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2002: Pekkone Eero; Hirvonen Jyrki; Ahveninen Jyrki; Kähkönen Seppo; Kaakkola Seppo; Huttunen Juha; Jääskeläinen Iiro P
Memory-based comparison process not attenuated by haloperidol: a combined MEG and EEG study.
Neuroreport 2002;13(1):177-81.
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2002: Ahveninen Jyrki; Jääskeläinen Iiro P; Kaakkola Seppo; Tiitinen Hannu; Pekkonen Eero
Aging and cholinergic modulation of the transient magnetic 40-Hz auditory response.
NeuroImage 2002;15(1):153-8.
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2002: Kaakkola Seppo; Larsen Andreo
[Neurological problems in a musician]
Duodecim; lääketieteellinen aikakauskirja 2002;118(15):1603-7.
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2001: Kähkönen S; Ahveninen J; Jääskeläinen I P; Kaakkola S; Näätänen R; Huttunen J; Pekkonen E
Effects of haloperidol on selective attention: a combined whole-head MEG and high-resolution EEG study.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;25(4):498-504.
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2001: Kähkönen S; Ahveninen J; Pekkonen E; Kaakkola S; Huttunen J; Peltonen T; Ilmoniemi R J; Jääskeläinen I P
No evidence for dependence of early cortical auditory processing on dopamine D(2)-receptor modulation: a whole-head magnetoencephalographic study.
Psychiatry research 2001;107(2):117-23.
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2001: Pekkonen E; Hirvonen J; Jääskeläinen I P; Kaakkola S; Huttunen J
Auditory sensory memory and the cholinergic system: implications for Alzheimer's disease.
NeuroImage 2001;14(2):376-82.
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2001: Huttunen J; Jääskeläinen I P; Hirvonen J; Kaakkola S; Ilmoniemi R J; Pekkonen E
Scopolamine reduces the P35m and P60m deflections of the human somatosensory evoked magnetic fields.
Neuroreport 2001;12(3):619-23.
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2001: Lyytinen J; Sovijärvi A; Kaakkola S; Gordin A; Teräväinen H
The effect of catechol-O-methyltransferase inhibition with entacapone on cardiovascular autonomic responses in L-Dopa-treated patients with Parkinson's disease.
Clinical neuropharmacology 2001;24(1):50-7.
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2000: Ahveninen J; Kähkönen S; Tiitinen H; Pekkonen E; Huttunen J; Kaakkola S; Ilmoniemi R J; Jääskeläinen I P
Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors.
Neuroscience letters 2000;292(1):29-32.
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2000: Juvonen V; Hietala M; Päivärinta M; Rantamäki M; Hakamies L; Kaakkola S; Vierimaa O; Penttinen M; Savontaus M L
Clinical and genetic findings in Finnish ataxia patients with the spinocerebellar ataxia 8 repeat expansion.
Annals of neurology 2000;48(3):354-61.
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2000: Kaakkola S
Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease.
Drugs 2000;59(6):1233-50.
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1999: Ahveninen J; Tiitinen H; Hirvonen J; Pekkonen E; Huttunen J; Kaakkola S; Jääskeläinen I P
Scopolamine augments transient auditory 40-hz magnetic response in humans.
Neuroscience letters 1999;277(2):115-8.
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1999: Jääskeläinen I P; Hirvonen J; Huttunen J; Kaakkola S; Pekkonen E
Scopolamine enhances middle-latency auditory evoked magnetic fields.
Neuroscience letters 1999;259(1):41-4.
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1997: Lyytinen J; Kaakkola S; Ahtila S; Tuomainen P; Teräväinen H
Simultaneous MAO-B and COMT inhibition in L-Dopa-treated patients with Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 1997;12(4):497-505.
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1995: Ahtila S; Kaakkola S; Gordin A; Korpela K; Heinävaara S; Karlsson M; Wikberg T; Tuomainen P; Männistö P T
Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers.
Clinical neuropharmacology 1995;18(1):46-57.
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1995: Karma A; Seppälä I; Mikkilä H; Kaakkola S; Viljanen M; Tarkkanen A
Diagnosis and clinical characteristics of ocular Lyme borreliosis.
American journal of ophthalmology 1995;119(2):127-35.
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1994: Kaakkola S; Gordin A; Männistö P T
General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase.
General pharmacology 1994;25(5):813-24.
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1994: Törnwall M; Kaakkola S; Tuomainen P; Kask A; Männistö P T
Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats.
British journal of pharmacology 1994;112(1):13-8.
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1994: Kaakkola S; Teräväinen H; Ahtila S; Rita H; Gordin A
Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients.
Neurology 1994;44(1):77-80.
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1994: Kaakkola S; Palo J; Malmberg H; Sulkava R; Virtanen I
Neurofilament profile in olfactory mucosa of patients with a clinical diagnosis of Alzheimer's disease.
Virchows Archiv : an international journal of pathology 1994;424(3):315-9.
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1993: Kaakkola S; Tuomainen P; Männistö P T; Palo J
Biogenic amine metabolites in the CSF of patients with late onset and alcoholic ataxias.
Acta neurologica Scandinavica 1993;87(4):309-11.
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1993: Iivanainen M; Kaakkola S
Dopa-responsive dystonia of childhood.
Developmental medicine and child neurology 1993;35(4):362-7.
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1993: Kaakkola S; Wurtman R J
Effects of catechol-O-methyltransferase inhibitors and L-3,4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum.
Journal of neurochemistry 1993;60(1):137-44.
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1993: Kaakkola S; Wurtman R J
Effects of two diketopiperazines, cyclo (His-Pro) and cyclo (Asp-Phe), on striatal dopamine: a microdialysis study.
Brain research bulletin 1993;32(6):667-72.
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1992: Gardier A M; Kaakkola S; Erfurth A; Wurtman R J
Effects of methiothepin on changes in brain serotonin release induced by repeated administration of high doses of anorectic serotoninergic drugs.
Brain research 1992;588(1):67-74.
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1992: Kaakkola S; Wurtman R J
Effects of COMT inhibitors on striatal dopamine metabolism: a microdialysis study.
Brain research 1992;587(2):241-9.
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1992: Kaakkola S; Tuomainen P; Wurtman R J; Männistö P T
Effects of systemic carbidopa on dopamine synthesis in rat hypothalamus and striatum.
Journal of neural transmission. Parkinson's disease and dementia section 1992;4(2):143-54.
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1992: Männistö P T; Ulmanen I; Lundström K; Taskinen J; Tenhunen J; Tilgmann C; Kaakkola S
Characteristics of catechol O-methyl-transferase (COMT) and properties of selective COMT inhibitors.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 1992;39():291-350.
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1992: Teräväinen H; Kaakkola S
[Botulinum toxin, hope in the treatment of torticollis]
Duodecim; lääketieteellinen aikakauskirja 1992;108(5):440-2.
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1991: Kaakkola S; Rosenberg P H; Alila A; Erkinjuntti T; Sulkava R; Palo J
Platelet membrane fluidity in Alzheimer's disease and multi-infarct dementia: a spin label study.
Acta neurologica Scandinavica 1991;84(1):18-21.
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1990: Kaakkola S; Marnela K M; Oja S S; Icén A; Palo J
Leukocyte glutamate dehydrogenase and CSF amino acids in late onset ataxias.
Acta neurologica Scandinavica 1990;82(5):292-6.
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1990: Kaakkola S; Gordin A; Järvinen M; Wikberg T; Schultz E; Nissinen E; Pentikäinen P J; Rita H
Effect of a novel catechol-O-methyltransferase inhibitor, nitecapone, on the metabolism of L-dopa in healthy volunteers.
Clinical neuropharmacology 1990;13(5):436-47.
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1990: Kaakkola S; Marnela K M; Oja S S; Icén A; Palo J
Leukocyte glutamate dehydrogenase and CSF amino acids in late onset ataxias.
Acta neurologica Scandinavica 1990;82(4):225-9.
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1990: Kaakkola S; Teräväinen H
Animal models of parkinsonism.
Pharmacology & toxicology 1990;67(2):95-100.
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1990: Männistö P T; Kaakkola S
Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease.
Pharmacology & toxicology 1990;66(5):317-23.
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1990: Männistö P T; Tuomainen P; Toivonen M; Törnwall M; Kaakkola S
Effect of acute levodopa on brain catecholamines after selective MAO and COMT inhibition in male rats.
Journal of neural transmission. Parkinson's disease and dementia section 1990;2(1):31-43.
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1989: Etemadzadeh E; Koskinen L; Kaakkola S
Computerized rotometer apparatus for recording circling behavior.
Methods and findings in experimental and clinical pharmacology 1989;11(6):399-407.
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1989: Bäckström R; Honkanen E; Pippuri A; Kairisalo P; Pystynen J; Heinola K; Nissinen E; Linden I B; Männistö P T; Kaakkola S
Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors.
Journal of medicinal chemistry 1989;32(4):841-6.
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1989: Schultz E; Nissinen E; Kaakkola S
Determination of catechol-O-methyltransferase activity in erythrocytes by high performance liquid chromatography with electrochemical detection.
Biomedical chromatography : BMC 1989;3(2):64-7.
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1988: Lindén I B; Nissinen E; Etemadzadeh E; Kaakkola S; Männistö P; Pohto P
Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease.
The Journal of pharmacology and experimental therapeutics 1988;247(1):289-93.
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1988: Nissinen E; Lindén I B; Schultz E; Kaakkola S; Männistö P T; Pohto P
Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat.
European journal of pharmacology 1988;153(2-3):263-9.
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1988: Nissinen E; Tuominen R; Perhoniemi V; Kaakkola S
Catechol-O-methyltransferase activity in human and rat small intestine.
Life sciences 1988;42(25):2609-14.
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1988: Männistö P T; Kaakkola S; Nissinen E; Linden I B; Pohto P
Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase.
Life sciences 1988;43(18):1465-71.
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1987: Kaakkola S; Männistö P T; Nissinen E
Striatal membrane-bound and soluble catechol-O-methyl-transferase after selective neuronal lesions in the rat.
Journal of neural transmission 1987;69(3-4):221-8.
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1985: Kaakkola S; Männistö P T; Nissinen E; Vuorela A; Mäntylä R
The effect of an increased ratio of carbidopa to levodopa on the pharmacokinetics of levodopa.
Acta neurologica Scandinavica 1985;72(4):385-91.
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1981: Männistö P; Mattila J; Kaakkola S
Possible involvement of nigrostriatal dopamine system in the inhibition of thyrotropin secretion in the rat.
European journal of pharmacology 1981;76(4):403-9.
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