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Leevi Kääriäinen

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Pirjo Spuul; Giuseppe Balistreri; Leevi Kääriäinen; Tero Ahola
Phosphatidylinositol 3-kinase-, actin-, and microtubule-dependent transport of Semliki Forest Virus replication complexes from the plasma membrane to modified lysosomes.
Giuseppe Balistreri; Javier Caldentey; Leevi Kääriäinen; Tero Ahola
Enzymatic defects of the nsP2 proteins of Semliki Forest virus temperature-sensitive mutants.
Leevi Kääriäinen; Tero Ahola
[Not Available].

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All Publications

2010: Pirjo Spuul; Giuseppe Balistreri; Leevi Kääriäinen; Tero Ahola
Phosphatidylinositol 3-kinase-, actin-, and microtubule-dependent transport of Semliki Forest Virus replication complexes from the plasma membrane to modified lysosomes.
Journal of virology 2010;84(15):7543-57.
2007: Giuseppe Balistreri; Javier Caldentey; Leevi Kääriäinen; Tero Ahola
Enzymatic defects of the nsP2 proteins of Semliki Forest virus temperature-sensitive mutants.
Journal of virology 2007;81(6):2849-60.
2007: Leevi Kääriäinen; Tero Ahola
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2007;123(8):899-907.
2007: Pirjo Spuul; Anne Salonen; Andres Merits; Eija Jokitalo; Leevi Kääriäinen; Tero Ahola
Role of the amphipathic peptide of Semliki forest virus replicase protein nsP1 in membrane association and virus replication.
Journal of virology 2007;81(2):872-83.
2006: Valeria Lulla; Andres Merits; Peter Sarin; Leevi Kääriäinen; Sirkka Keränen; Tero Ahola
Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis.
Journal of virology 2006;80(6):3108-11.
2006: Andrey Golubtsov; Leevi Kääriäinen; Javier Caldentey
Characterization of the cysteine protease domain of Semliki Forest virus replicase protein nsP2 by in vitro mutagenesis.
FEBS letters 2006;580(5):1502-8.
2005: Julia Magden; Leevi Kääriäinen; Tero Ahola
Inhibitors of virus replication: recent developments and prospects.
Applied microbiology and biotechnology 2005;66(6):612-21.
2005: Anne Salonen; Tero Ahola; Leevi Kääriäinen
Viral RNA replication in association with cellular membranes.
Current topics in microbiology and immunology 2005;285():139-73.
2003: Lidia Vasiljeva; Andres Merits; Andrey Golubtsov; Valeria Sizemskaja; Leevi Kääriäinen; Tero Ahola
Regulation of the sequential processing of Semliki Forest virus replicase polyprotein.
The Journal of biological chemistry 2003;278(43):41636-45.
2003: Anne Salonen; Lidia Vasiljeva; Andres Merits; Julia Magden; Eija Jokitalo; Leevi Kääriäinen
Properly folded nonstructural polyprotein directs the semliki forest virus replication complex to the endosomal compartment.
Journal of virology 2003;77(3):1691-702.
2002: Leevi Kääriäinen; Tero Ahola
Functions of alphavirus nonstructural proteins in RNA replication.
Progress in nucleic acid research and molecular biology 2002;71():187-222.
2002: John Fazakerley; Amanda Boyd; Marja L Mikkola; Leevi Kääriäinen
A single amino acid change in the nuclear localization sequence of the nsP2 protein affects the neurovirulence of Semliki Forest virus.
Journal of virology 2002;76(1):392-6.
2001: Arja M Band; J Määttä; Leevi Kääriäinen; Esa Kuismanen
Inhibition of the membrane fusion machinery prevents exit from the TGN and proteolytic processing by furin.
FEBS letters 2001;505(1):118-24.
2001: Lidia Vasiljeva; Leena Valmu; Leevi Kääriäinen; Andres Merits
Site-specific protease activity of the carboxyl-terminal domain of Semliki Forest virus replicase protein nsP2.
The Journal of biological chemistry 2001;276(33):30786-93.
2001: Julia Magden; N Takeda; T Li; Petri Auvinen; Tero Ahola; T Miyamura; Andres Merits; Leevi Kääriäinen
Virus-specific mRNA capping enzyme encoded by hepatitis E virus.
Journal of virology 2001;75(14):6249-55.
2001: Pekka Kujala; A Ikäheimonen; N Ehsani; Helena Vihinen; Petri Auvinen; Leevi Kääriäinen
Biogenesis of the Semliki Forest virus RNA replication complex.
Journal of virology 2001;75(8):3873-84.
2001: Andres Merits; Lidia Vasiljeva; Tero Ahola; Leevi Kääriäinen; Petri Auvinen
Proteolytic processing of Semliki Forest virus-specific non-structural polyprotein by nsP2 protease.
The Journal of general virology 2001;82(Pt 4):765-73.
2001: Helena Vihinen; Tero Ahola; Minna Tuittila; Andres Merits; Leevi Kääriäinen
Elimination of phosphorylation sites of Semliki Forest virus replicase protein nsP3.
The Journal of biological chemistry 2001;276(8):5745-52.
2000: A Lampio; I Kilpeläinen; S Pesonen; K Karhi; Petri Auvinen; P Somerharju; Leevi Kääriäinen
Membrane binding mechanism of an RNA virus-capping enzyme.
The Journal of biological chemistry 2000;275(48):37853-9.
2000: Lidia Vasiljeva; Andres Merits; Petri Auvinen; Leevi Kääriäinen
Identification of a novel function of the alphavirus capping apparatus. RNA 5'-triphosphatase activity of Nsp2.
The Journal of biological chemistry 2000;275(23):17281-7.
1999: Pekka Kujala; Tero Ahola; N Ehsani; Petri Auvinen; Helena Vihinen; Leevi Kääriäinen
Intracellular distribution of rubella virus nonstructural protein P150.
Journal of virology 1999;73(9):7805-11.
1999: Andres Merits; R Kettunen; Kristiina Mäkinen; A Lampio; Petri Auvinen; Leevi Kääriäinen; Tero Ahola
Virus-specific capping of tobacco mosaic virus RNA: methylation of GTP prior to formation of covalent complex p126-m7GMP.
FEBS letters 1999;455(1-2):45-8.
1999: Tero Ahola; A Lampio; Petri Auvinen; Leevi Kääriäinen
Semliki Forest virus mRNA capping enzyme requires association with anionic membrane phospholipids for activity.
The EMBO journal 1999;18(11):3164-72.
1999: A Lampio; Tero Ahola; Edward Darzynkiewicz; Janusz Stepinski; Marzena Jankowska-Anyszka; Leevi Kääriäinen
Guanosine nucleotide analogs as inhibitors of alphavirus mRNA capping enzyme.
Antiviral research 1999;42(1):35-46.
1999: M Gomez de Cedrón; N Ehsani; Marja L Mikkola; J A García; Leevi Kääriäinen
RNA helicase activity of Semliki Forest virus replicase protein NSP2.
FEBS letters 1999;448(1):19-22.
1998: Pirjo Laakkonen; Petri Auvinen; Pekka Kujala; Leevi Kääriäinen
Alphavirus replicase protein NSP1 induces filopodia and rearrangement of actin filaments.
Journal of virology 1998;72(12):10265-9.
1998: J Suopanki; Dorothea L Sawicki; Stanley G Sawicki; Leevi Kääriäinen
Regulation of alphavirus 26S mRNA transcription by replicase component nsP2.
The Journal of general virology 1998;79 ( Pt 2)():309-19.
1997: Pekka Kujala; M Rikkonen; Tero Ahola; M Kelve; Mart Saarma; Leevi Kääriäinen
Monoclonal antibodies specific for Semliki Forest virus replicase protein nsP2.
The Journal of general virology 1997;78 ( Pt 2)():343-51.
1997: Leevi Kääriäinen
[Archaea a third basic form of life found at the bottom of the sea].
Duodecim; lääketieteellinen aikakauskirja 1997;113(3):179-80.
1997: Tero Ahola; Pirjo Laakkonen; Helena Vihinen; Leevi Kääriäinen
Critical residues of Semliki Forest virus RNA capping enzyme involved in methyltransferase and guanylyltransferase-like activities.
Journal of virology 1997;71(1):392-7.
1996: Pirjo Laakkonen; Tero Ahola; Leevi Kääriäinen
The effects of palmitoylation on membrane association of Semliki forest virus RNA capping enzyme.
The Journal of biological chemistry 1996;271(45):28567-71.
1996: P Russo; Pirjo Laakkonen; Tero Ahola; Leevi Kääriäinen
Synthesis of Semliki Forest virus RNA polymerase components nsP1 through nsP4 in Saccharomyces cerevisiae by expression of cDNA encoding the nonstructural polyprotein.
Journal of virology 1996;70(6):4086-9.
1996: J Peränen; M Rikkonen; M Hyvönen; Leevi Kääriäinen
T7 vectors with modified T7lac promoter for expression of proteins in Escherichia coli.
Analytical biochemistry 1996;236(2):371-3.
1995: J Peränen; Pirjo Laakkonen; M Hyvönen; Leevi Kääriäinen
The alphavirus replicase protein nsP1 is membrane-associated and has affinity to endocytic organelles.
Virology 1995;208(2):610-20.
1995: Tero Ahola; Leevi Kääriäinen
Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):507-11.
1994: Pirjo Laakkonen; M Hyvönen; J Peränen; Leevi Kääriäinen
Expression of Semliki Forest virus nsP1-specific methyltransferase in insect cells and in Escherichia coli.
Journal of virology 1994;68(11):7418-25.
1994: M Rikkonen; J Peränen; Leevi Kääriäinen
ATPase and GTPase activities associated with Semliki Forest virus nonstructural protein nsP2.
Journal of virology 1994;68(9):5804-10.
1994: M Rikkonen; J Peränen; Leevi Kääriäinen
Nuclear targeting of Semliki Forest virus nsP2.
Archives of virology. Supplementum 1994;9():369-77.
1993: J Peränen; M Rikkonen; Leevi Kääriäinen
A method for exposing hidden antigenic sites in paraformaldehyde-fixed cultured cells, applied to initially unreactive antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993;41(3):447-54.
1992: M Rikkonen; J Peränen; Leevi Kääriäinen
Nuclear and nucleolar targeting signals of Semliki Forest virus nonstructural protein nsP2.
Virology 1992;189(2):462-73.
1992: I Palva; Matti Sarvas; P Lehtovaara; M Sibakov; Leevi Kääriäinen
Secretion of Escherichia coli beta-lactamase from Bacillus subtilis by the aid of alpha-amylase signal sequence. 1982.
Biotechnology (Reading, Mass.) 1992;24():344-8.
1991: Kristiina Takkinen; J Peränen; Leevi Kääriäinen
Proteolytic processing of Semliki Forest virus-specific non-structural polyprotein.
The Journal of general virology 1991;72 ( Pt 7)():1627-33.
1991: J Peränen; Leevi Kääriäinen
Biogenesis of type I cytopathic vacuoles in Semliki Forest virus-infected BHK cells.
Journal of virology 1991;65(3):1623-7.
1990: P Syväoja; J Peränen; M Suomalainen; Sirkka Keränen; Leevi Kääriäinen
A single amino acid change in E3 of ts1 mutant inhibits the intracellular transport of SFV envelope protein complex.
Virology 1990;179(2):658-66.
1990: J Peränen; M Rikkonen; P Liljeström; Leevi Kääriäinen
Nuclear localization of Semliki Forest virus-specific nonstructural protein nsP2.
Journal of virology 1990;64(5):1888-96.
1990: Kristiina Takkinen; J Peränen; Sirkka Keränen; Hans Söderlund; Leevi Kääriäinen
The Semliki-Forest-virus-specific nonstructural protein nsP4 is an autoproteinase.
European journal of biochemistry / FEBS 1990;189(1):33-8.
1988: J Peränen; Kristiina Takkinen; Nisse Kalkkinen; Leevi Kääriäinen
Semliki Forest virus-specific non-structural protein nsP3 is a phosphoprotein.
The Journal of general virology 1988;69 ( Pt 9)():2165-78.
1987: G Vidgren; Kristiina Takkinen; Nisse Kalkkinen; Leevi Kääriäinen; R F Pettersson
Nucleotide sequence of the genes coding for the membrane glycoproteins E1 and E2 of rubella virus.
The Journal of general virology 1987;68 ( Pt 9)():2347-57.
1987: Leevi Kääriäinen; Kristiina Takkinen; Sirkka Keränen; Hans Söderlund
Replication of the genome of alphaviruses.
Journal of cell science. Supplement 1987;7():231-50.
1986: N Kalkkinen; M Sibakov; Matti Sarvas; I Palva; Leevi Kääriäinen
Amino-terminal heterogeneity of E. coli TEM-beta-lactamase secreted from Bacillus subtilis.
FEBS letters 1986;200(1):18-22.
1985: K Lundström; I Palva; Leevi Kääriäinen; H Garoff; M Sarvas; R F Pettersson
Secretion of Semliki Forest virus membrane glycoprotein E1 from Bacillus subtilis.
Virus research 1985;2(1):69-83.
1984: Leevi Kääriäinen; M Ranki
Inhibition of cell functions by RNA-virus infections.
Annual review of microbiology 1984;38():91-109.
1983: R F Pettersson; K Lundström; J B Chattopadhyaya; S Josephson; L Philipson; Leevi Kääriäinen; I Palva
Chemical synthesis and molecular cloning of a STOP oligonucleotide encoding an UGA translation terminator in all three reading frames.
Gene 1983;24(1):15-27.
1983: I Palva; P Lehtovaara; Leevi Kääriäinen; M Sibakov; K Cantell; C H Schein; K Kashiwagi; C Weissmann
Secretion of interferon by Bacillus subtilis.
Gene 1983;22(2-3):229-35.
1983: Kristiina Takkinen; R F Pettersson; Nisse Kalkkinen; I Palva; Hans Söderlund; Leevi Kääriäinen
Amino acid sequence of alpha-amylase from Bacillus amyloliquefaciens deduced from the nucleotide sequence of the cloned gene.
The Journal of biological chemistry 1983;258(2):1007-13.
1983: Leevi Kääriäinen; I Virtanen; Jaakko Saraste; S Keränen
Transport of virus membrane glycoproteins, use of temperature-sensitive mutants and organelle-specific lectins.
Methods in enzymology 1983;96():453-65.
1983: M Ranki; M Virtanen; A Palva; M Laaksonen; R Pettersson; Leevi Kääriäinen; P Halonen; Hans Söderlund
Nucleic acid sandwich hybridization in adenovirus diagnosis.
Current topics in microbiology and immunology 1983;104():307-18.
1982: I Palva; Matti Sarvas; P Lehtovaara; M Sibakov; Leevi Kääriäinen
Secretion of Escherichia coli beta-lactamase from Bacillus subtilis by the aid of alpha-amylase signal sequence.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(18):5582-6.
1982: M Pesonen; Leevi Kääriäinen
Incomplete complex oligosaccharides in semliki forest virus envelope proteins arrested within the cell in the presence of monensin.
Journal of molecular biology 1982;158(2):213-30.
1982: P Lehtovaara; Hans Söderlund; Sirkka Keränen; R F Pettersson; Leevi Kääriäinen
Extreme ends of the genome are conserved and rearranged in the defective interfering RNAs of Semliki Forest virus.
Journal of molecular biology 1982;156(4):731-48.
1982: P Ukkonen; Jaakko Saraste; K Korpela; M Pesonen; Leevi Kääriäinen
Temperature-dependent internalization of virus glycoproteins in cells infected with a mutant of Semliki Forest virus.
The EMBO journal 1982;1(2):191-6.
1981: Stanley G Sawicki; Dorothea L Sawicki; Leevi Kääriäinen; S Keränen
A Sindbis virus mutant temperature-sensitive in the regulation of minus-strand RNA synthesis.
Virology 1981;115(1):161-72.
1981: I Palva; R F Pettersson; Nisse Kalkkinen; P Lehtovaara; Matti Sarvas; Hans Söderlund; Kristiina Takkinen; Leevi Kääriäinen
Nucleotide sequence of the promoter and NH2-terminal signal peptide region of the alpha-amylase gene from Bacillus amyloliquefaciens.
Gene 1981;15(1):43-51.
1981: Leevi Kääriäinen; R F Pettersson; Sirkka Keränen; P Lehtovaara; Hans Söderlund; P Ukkonen
Multiple structurally related defective-interfering RNAs formed during undiluted passages of Semliki forest virus.
Virology 1981;113(2):686-97.
1981: P Lehtovaara; Hans Söderlund; Sirkka Keränen; R F Pettersson; Leevi Kääriäinen
18S defective interfering RNA of Semliki Forest virus contains a triplicated linear repeat.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(9):5353-7.
1981: Dorothea L Sawicki; Stanley G Sawicki; S Keränen; Leevi Kääriäinen
Specific Sindbis virus-coded function for minus-strand RNA synthesis.
Journal of virology 1981;39(2):348-58.
1981: Hans Söderlund; Sirkka Keränen; P Lehtovaara; I Palva; R F Pettersson; Leevi Kääriäinen
Structural complexity of defective-interfering RNAs of Semliki Forest virus as revealed by analysis of complementary DNA.
Nucleic acids research 1981;9(14):3403-17.
1981: Katsuyuki Hashimoto; S Erdei; S Keränen; Jaakko Saraste; Leevi Kääriäinen
Evidence for a separate signal sequence for the carboxy-terminal envelope glycoprotein E1 of Semliki forest virus.
Journal of virology 1981;38(1):34-40.
1981: M Pesonen; Jaakko Saraste; Katsuyuki Hashimoto; Leevi Kääriäinen
Reversible defect in the glycosylation of the membrane proteins of Semliki Forest virus ts-1 mutant.
Virology 1981;109(1):165-73.
1980: P Lehtovaara; Ismo Ulmanen; Leevi Kääriäinen; Sirkka Keränen; L Philipson
Synthesis and processing of Semliki Forest virus-specific nonstructural proteins in vivo and in vitro.
European journal of biochemistry / FEBS 1980;112(3):461-8.
1980: Leevi Kääriäinen; Katsuyuki Hashimoto; Jaakko Saraste; I Virtanen; K Penttinen
Monensin and FCCP inhibit the intracellular transport of alphavirus membrane glycoproteins.
The Journal of cell biology 1980;87(3 Pt 1):783-91.
1980: P J Gomatos; Leevi Kääriäinen; S Keränen; M Ranki; Dorothea L Sawicki
Semliki Forest virus replication complex capable of synthesizing 42S and 26S nascent RNA chains.
The Journal of general virology 1980;49(1):61-9.
1980: Jaakko Saraste; C H von Bonsdorff; Katsuyuki Hashimoto; S Keränen; Leevi Kääriäinen
Reversible transport defects of virus membrane glycoproteins in Sindbis virus mutant infected cells.
Cell biology international reports 1980;4(3):279-86.
1980: Jaakko Saraste; C H von Bonsdorff; Katsuyuki Hashimoto; Leevi Kääriäinen; S Keränen
Semliki forest virus mutants with temperature-sensitive transport defect of envelope proteins.
Virology 1980;100(2):229-45.