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Kai Kaarniranta

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Susanna Porela-Tiihonen; Kai Kaarniranta; Hannu Kokki
Postoperative pain after cataract surgery.
Juha M T Hyttinen; M Niittykoski; Antero Salminen; Kai Kaarniranta
Maturation of autophagosomes and endosomes: a key role for Rab7.
Pasi Vottonen; Kai Kaarniranta; Ari Pääkkönen; Ina M Tarkka
Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration.

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All Publications

2013: Susanna Porela-Tiihonen; Kai Kaarniranta; Hannu Kokki
Postoperative pain after cataract surgery.
Journal of cataract and refractive surgery 2013;39(5):789-98.
2013: Juha M T Hyttinen; M Niittykoski; Antero Salminen; Kai Kaarniranta
Maturation of autophagosomes and endosomes: a key role for Rab7.
Biochimica et biophysica acta 2013;1833(3):503-10.
2013: Pasi Vottonen; Kai Kaarniranta; Ari Pääkkönen; Ina M Tarkka
Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration.
Clinical ophthalmology (Auckland, N.Z.) 2013;7():437-42.
2013: Antero Salminen; Kai Kaarniranta; Anu Kauppinen
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process.
International journal of molecular sciences 2013;14(2):3834-59.
2013: Janusz Blasiak; Sylwester Glowacki; Anu Kauppinen; Kai Kaarniranta
Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration.
International journal of molecular sciences 2013;14(2):2996-3010.
2013: Janusz Blasiak; Antero Salminen; Kai Kaarniranta
Potential of epigenetic mechanisms in AMD pathology.
Frontiers in bioscience (Scholar edition) 2013;5():412-25.
2012: Kai Kaarniranta; Anu Kauppinen; Janusz Blasiak; Antero Salminen
Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration.
Future medicinal chemistry 2012;4(17):2153-61.
2012: Paavo K J Kinnunen; Kai Kaarniranta; Ajay K Mahalka
Protein-oxidized phospholipid interactions in cellular signaling for cell death: From biophysics to clinical correlations.
Biochimica et biophysica acta 2012;1818(10):2446-55.
2012: Anu Kauppinen; Kati Kinnunen; Henri Niskanen; Antero Salminen; Tiina Suuronen; Kai Kaarniranta
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD).
Immunology letters 2012;147(1-2):29-33.
2012: Antero Salminen; Johanna Ojala; Kai Kaarniranta; Anu Kauppinen
Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases.
Cellular and molecular life sciences : CMLS 2012;69(18):2999-3013.
2012: Olavi Pärssinen; Henrik Hiltunen; Kai Kaarniranta
Relation of biometric eye profile with intraocular pressure corrections in healthy myopes.
Acta ophthalmologica 2012;90(5):e410-2.
2012: Kati Kinnunen; Morten C Moe; Goran Petrovski; András Berta; Kai Kaarniranta
Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration.
Acta ophthalmologica 2012;90(4):299-309.
2012: Kai Kaarniranta; Tanja Nevalainen; Jussi Paananen; Leena Pulkkinen; Antero Salminen; Sanna Seitsonen; Iiris Sorri; Ilkka Immonen; Matti Uusitupa
Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population.
Neuroscience letters 2012;513(2):233-7.
2012: Antero Salminen; Kai Kaarniranta
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network.
Ageing research reviews 2012;11(2):230-41.
2012: Antero Salminen; Anu Kauppinen; Kai Kaarniranta
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).
Cellular signalling 2012;24(4):835-45.
2012: Antero Salminen; Kai Kaarniranta; Anu Kauppinen
Inflammaging: disturbed interplay between autophagy and inflammasomes.
Aging 2012;4(3):166-75.
2012: Janusz Blasiak; Antero Salminen; Ewelina Synowiec; Kai Kaarniranta
Genetic variability in DNA repair proteins in age-related macular degeneration.
International journal of molecular sciences 2012;13(10):13378-97.
2012: Otto T Mykkänen; Riitta Törrönen; Michiel Adriaens; Chris T Evelo; Giedrius Kalesnykas; Kai Kaarniranta
Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice.
Molecular vision 2012;18():2338-51.
2012: Antero Salminen; Anu Kauppinen; Juha M T Hyttinen; Kai Kaarniranta
Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process.
International journal of cell biology 2012;2012():849541.
2012: Eszter Szalai; László Módis; András Berta; Szabolcs Felszeghy; Zoltán Hegyi; Kai Kaarniranta
Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies.
Molecular vision 2012;18():1927-36.
2012: Tuomas Paimela; Tuomas Ryhänen; Antero Salminen; Anu Kauppinen; Liisa Marttila; Kai Kaarniranta
The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells.
Molecular vision 2012;18():1189-96.
2012: Juha Seppä; Grigori Smirnov; Kai Kaarniranta; Henri Tuomilehto
[Surgery for lower nasolacrimal duct obstructions in adults].
Duodecim; lääketieteellinen aikakauskirja 2012;128(2):205-11.
2012: Kati Juuti-Uusitalo; Kai Kaarniranta; Eliisa Mannermaa; Susanna Narkilahti; Tuomas Ryhänen; Riitta Suuronen; Hanna Vaajasaari; Heli Skottman
Efflux protein expression in human stem cell-derived retinal pigment epithelial cells.
PloS one 2012;7(1):e30089.
2012: Antero Salminen; Hilkka Soininen; Annakaisa Haapasalo; Mikko Hiltunen; Kai Kaarniranta; Irina Alafuzoff
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease.
Progress in neurobiology 2012;96(1):87-95.
2011: Tuomas Paimela; Tuomas Ryhänen; Antero Salminen; Johanna Viiri; Juha M T Hyttinen; Reijo O Karjalainen; Kai Kaarniranta
Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(5):501-8.
2011: Antero Salminen; Hilkka Soininen; Annakaisa Haapasalo; Kai Kaarniranta; Mikko Hiltunen
AMP-activated protein kinase: a potential player in Alzheimer's disease.
Journal of neurochemistry 2011;118(4):460-74.
2011: Antero Salminen; Annakaisa Haapasalo; Mikko Hiltunen; Kai Kaarniranta; Johanna Ojala; Hilkka Soininen
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype.
The European journal of neuroscience 2011;34(1):3-11.
2011: Antero Salminen; Juha M T Hyttinen; Kai Kaarniranta
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan.
Journal of molecular medicine (Berlin, Germany) 2011;89(7):667-76.
2011: Antero Salminen; Kai Kaarniranta
Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging.
Cellular signalling 2011;23(5):747-52.
2011: Antero Salminen; Johanna Ojala; Kai Kaarniranta
Apoptosis and aging: increased resistance to apoptosis enhances the aging process.
Cellular and molecular life sciences : CMLS 2011;68(6):1021-31.
2011: Grigori Smirnov; Risto Pirinen; Henri Tuomilehto; Juha Seppä; Markku Teräsvirta; Hannu Uusitalo; Juhani Nuutinen; Kai Kaarniranta
Strong expression of HSP47 in metaplastic nasal mucosa may predict a poor outcome after primary endoscopic dacryocystorhinostomy: a prospective study.
Acta ophthalmologica 2011;89(2):e132-6.
2011: Hanna-Mari Jauhonen; Anu Kauppinen; Jarmo Laihia; Lasse Leino; Tuomas Paimela; Antero Salminen; Kai Kaarniranta
Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro.
Molecular vision 2011;17():2311-7.
2011: Kai Kaarniranta; Antero Salminen; Hilkka Soininen; Annakaisa Haapasalo; Mikko Hiltunen
Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
Journal of Alzheimer's disease : JAD 2011;24(4):615-31.
2011: Seppo Rönkkö; Kai Kaarniranta; Giedrius Kalesnykas; Hannu Uusitalo
Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats.
Ophthalmic research 2011;46(2):55-65.
2011: Antero Salminen; Johanna Ojala; Kai Kaarniranta; Mikko Hiltunen; Hilkka Soininen
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease.
Progress in neurobiology 2011;93(1):99-110.
2011: Tuomas Ryhänen; Johanna Viiri; Juha M T Hyttinen; Hannu Uusitalo; Antero Salminen; Kai Kaarniranta
Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells.
Journal of biomedicine & biotechnology 2011;2011():798052.
2010: M Niittykoski; Giedrius Kalesnykas; Kim P Larsson; Kai Kaarniranta; Karl E O Akerman; Hannu Uusitalo
Altered calcium signaling in an experimental model of glaucoma.
Investigative ophthalmology & visual science 2010;51(12):6387-93.
2010: Antero Salminen; Anu Kauppinen; Juha Mt Hyttinen; Elisa Toropainen; Kai Kaarniranta
Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization.
Molecular medicine (Cambridge, Mass.) 2010;16(11-12):535-42.
2010: Tuomas Paimela; Juha M T Hyttinen; Johanna Viiri; Tuomas Ryhänen; Matti K Karvonen; Mikko Unkila; Hannu Uusitalo; Antero Salminen; Kai Kaarniranta
Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19).
European journal of pharmacology 2010;640(1-3):219-25.
2010: Eliisa Mannermaa; Mika Reinisalo; Veli-Pekka Ranta; Kati-Sisko Vellonen; Hannu Kokki; Anni Saarikko; Kai Kaarniranta; Arto Urtti
Filter-cultured ARPE-19 cells as outer blood-retinal barrier model.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2010;40(4):289-96.
2010: Antero Salminen; Kai Kaarniranta
ER stress and hormetic regulation of the aging process.
Ageing research reviews 2010;9(3):211-7.
2010: Antero Salminen; Kai Kaarniranta
Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process.
Journal of cellular physiology 2010;224(1):1-6.
2010: Antero Salminen; Kai Kaarniranta
Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process.
Ageing research reviews 2010;9(3):298-314.
2010: Kai Kaarniranta
Autophagy--hot topic in AMD.
Acta ophthalmologica 2010;88(4):387-8.
2010: Hannu Uusitalo; Enping Chen; Norbert Pfeiffer; Françoise Brignole-Baudouin; Kai Kaarniranta; Markku Leino; Päivi Puska; Elina Palmgren; Thomas Hamacher; Günter Hofmann; Gernot Petzold; Ulrich Richter; Tobias Riedel; Martin Winter; Auli Ropo
Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication.
Acta ophthalmologica 2010;88(3):329-36.
2010: Matti Kontkanen; Leena Paimela; Kai Kaarniranta
Regression of necrotizing scleritis in Wegener's granulomatosis after infliximab treatment.
Acta ophthalmologica 2010;88(3):e96-7.
2010: Antero Salminen; Marko Lehtonen; Tuomas Paimela; Kai Kaarniranta
Celastrol: Molecular targets of Thunder God Vine.
Biochemical and biophysical research communications 2010;394(3):439-42.
2010: Antero Salminen; Kai Kaarniranta
Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling.
Cellular signalling 2010;22(4):573-7.
2010: Johanna Viiri; Juha M T Hyttinen; Tuomas Ryhänen; Kirsi Rilla; Tuomas Paimela; Erkki Kuusisto; Ari Siitonen; Arto Urtti; Antero Salminen; Kai Kaarniranta
p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells.
Molecular vision 2010;16():1399-414.
2010: Kai Kaarniranta; Juha M T Hyttinen; Tuomas Ryhanen; Johanna Viiri; Tuomas Paimela; Elisa Toropainen; Iiris Sorri; Antero Salminen
Mechanisms of protein aggregation in the retinal pigment epithelial cells.
Frontiers in bioscience (Elite edition) 2010;2():1374-84.
2009: Kai Kaarniranta; Antero Salminen
NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD).
Experimental gerontology 2009;44(11):685-8.
2009: Olli Arjamaa; Mikko Nikinmaa; Antero Salminen; Kai Kaarniranta
Regulatory role of HIF-1alpha in the pathogenesis of age-related macular degeneration (AMD).
Ageing research reviews 2009;8(4):349-58.
2009: Antero Salminen; Kai Kaarniranta
SIRT1: regulation of longevity via autophagy.
Cellular signalling 2009;21(9):1356-60.
2009: Tuomas Ryhänen; Juha M T Hyttinen; Jürgen Kopitz; Kirsi Rilla; Erkki Kuusisto; Eliisa Mannermaa; Johanna Viiri; Carina I Holmberg; Ilkka Immonen; Seppo Meri; Jussi Parkkinen; Eeva-Liisa Eskelinen; Hannu Uusitalo; Antero Salminen; Kai Kaarniranta
Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells.
Journal of cellular and molecular medicine 2009;13(9B):3616-31.
2009: Antero Salminen; Kai Kaarniranta
NF-kappaB signaling in the aging process.
Journal of clinical immunology 2009;29(4):397-405.
2009: Antero Salminen; Kai Kaarniranta
Siglec receptors and hiding plaques in Alzheimer's disease.
Journal of molecular medicine (Berlin, Germany) 2009;87(7):697-701.
2009: Eliisa Mannermaa; Kati-Sisko Vellonen; Tuomas Ryhänen; Katriina Kokkonen; Veli-Pekka Ranta; Kai Kaarniranta; Arto Urtti
Efflux protein expression in human retinal pigment epithelium cell lines.
Pharmaceutical research 2009;26(7):1785-91.
2009: Matti Kontkanen; Kai Kaarniranta
Retinal haemorrhages in shaken baby syndrome.
Acta ophthalmologica 2009;87(4):471-3.
2009: Antero Salminen; Kai Kaarniranta
Regulation of the aging process by autophagy.
Trends in molecular medicine 2009;15(5):217-24.
2009: Kai Kaarniranta; Antero Salminen; Eeva-Liisa Eskelinen; Jürgen Kopitz
Heat shock proteins as gatekeepers of proteolytic pathways-Implications for age-related macular degeneration (AMD).
Ageing research reviews 2009;8(2):128-39.
2009: Seppo Rönkkö; Petri Rekonen; Roope Sihvola; Kai Kaarniranta; Tuomo Puustjärvi; Markku Teräsvirta; Hannu Uusitalo
Histopathology of the three implanted degradable biopolymers in rabbit eye.
Journal of biomedical materials research. Part A 2009;88(3):717-24.
2009: Antero Salminen; Johanna Ojala; Anu Kauppinen; Kai Kaarniranta; Tiina Suuronen
Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors.
Progress in neurobiology 2009;87(3):181-94.
2009: Kai Kaarniranta; Antero Salminen
Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors.
Journal of molecular medicine (Berlin, Germany) 2009;87(2):117-23.
2009: Antero Salminen; Kai Kaarniranta
SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree.
Biochemical and biophysical research communications 2009;378(1):6-9.
2009: Antero Salminen; Anu Kauppinen; Tiina Suuronen; Kai Kaarniranta; Johanna Ojala
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology.
Journal of neuroinflammation 2009;6():41.
2009: J Viiri; H M Jauhonen; A Kauppinen; Tuomas Ryhänen; T Paimela; J Hyttinen; I Sorri; J K Laihia; L Leino; Kai Kaarniranta
Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro.
Molecular vision 2009;15():1799-805.
2009: Anna-Maija Tolppanen; Tanja Nevalainen; Marjukka Kolehmainen; Sanna Seitsonen; Ilkka Immonen; Matti Uusitupa; Kai Kaarniranta; Leena Pulkkinen
Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration.
Molecular vision 2009;15():762-70.
2009: Kai Kaarniranta; Sanna Seitsonen; Tuomas Paimela; Seppo Meri; Ilkka Immonen
[Pathogenesis of age-related macular degeneration].
Duodecim; lääketieteellinen aikakauskirja 2009;125(2):145-53.
2008: Antero Salminen; Johanna Ojala; Tiina Suuronen; Kai Kaarniranta; Anu Kauppinen
Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology.
Journal of cellular and molecular medicine 2008;12(6A):2255-62.
2008: Antero Salminen; Anu Kauppinen; Tiina Suuronen; Kai Kaarniranta
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?
BioEssays : news and reviews in molecular, cellular and developmental biology 2008;30(10):939-42.
2008: Antero Salminen; Marko Lehtonen; Tiina Suuronen; Kai Kaarniranta; Jari Huuskonen
Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential.
Cellular and molecular life sciences : CMLS 2008;65(19):2979-99.
2008: Tiina Suuronen; Johanna Ojala; Juha M T Hyttinen; Kai Kaarniranta; Anders Thornell; Sergiy Kyrylenko; Antero Salminen
Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90.
Neurochemical research 2008;33(9):1768-75.
2008: Antero Salminen; Tiina Suuronen; Kai Kaarniranta
ROCK, PAK, and Toll of synapses in Alzheimer's disease.
Biochemical and biophysical research communications 2008;371(4):587-90.
2008: Tuomas Ryhänen; Eliisa Mannermaa; Niku K J Oksala; Johanna Viiri; Tuomas Paimela; Antero Salminen; Mustafa Atalay; Kai Kaarniranta
Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells.
European journal of pharmacology 2008;584(2-3):229-36.
2008: Antero Salminen; Tuomas Paimela; Tiina Suuronen; Kai Kaarniranta
Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90.
Immunology letters 2008;117(1):9-15.
2008: Antero Salminen; Johanna Ojala; Jari Huuskonen; A Kauppinen; Tiina Suuronen; Kai Kaarniranta
Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1.
Cellular and molecular life sciences : CMLS 2008;65(7-8):1049-58.
2008: Antero Salminen; Jari Huuskonen; Johanna Ojala; Anu Kauppinen; Kai Kaarniranta; Tiina Suuronen
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging.
Ageing research reviews 2008;7(2):83-105.
2008: Antero Salminen; Tiina Suuronen; Jari Huuskonen; Kai Kaarniranta
NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?
Biochemical and biophysical research communications 2008;367(4):715-8.
2008: Anne Huhtala; Timo Pohjonen; Lotta Salminen; Antero Salminen; Kai Kaarniranta; Hannu Uusitalo
In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: extraction studies.
Journal of materials science. Materials in medicine 2008;19(2):645-9.
2008: Sanna P Seitsonen; Päivi Onkamo; Gang Peng; Momiao Xiong; Petri Tommila; Päivi Ranta; Juha M Holopainen; Jukka A O Moilanen; Tapani Palosaari; Kai Kaarniranta; Seppo Meri; Ilkka R Immonen; Irma Järvelä
Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration.
PloS one 2008;3(12):e3833.
2008: Hannu Uusitalo; Kai Kaarniranta; Auli Ropo
Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers.
Acta ophthalmologica. Supplement 2008;242():7-13.
2007: Giedrius Kalesnykas; M Niittykoski; J Rantala; Riitta Miettinen; Antero Salminen; Kai Kaarniranta; Hannu Uusitalo
The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model.
Neuroscience 2007;150(3):692-704.
2007: Anne Huhtala; T Pohjonen; Lotta Salminen; A Salminen; Kai Kaarniranta; Hannu Uusitalo
In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: direct contact studies.
Journal of biomedical materials research. Part A 2007;83(2):407-13.
2007: Jari Leppälä; Kai Kaarniranta; Hannu Uusitalo; Matti Kontkanen
Imiquimod in the treatment of eyelid basal cell carcinoma.
Acta ophthalmologica Scandinavica 2007;85(5):566-8.
2007: Tuomas Paimela; Tuomas Ryhänen; Eliisa Mannermaa; Johanna Ojala; Giedrius Kalesnykas; Antero Salminen; Kai Kaarniranta
The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells.
Immunology letters 2007;110(2):139-44.
2007: Tiina Suuronen; Tapio Nuutinen; Tuomas Ryhänen; Kai Kaarniranta; Antero Salminen
Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells.
Biochemical and biophysical research communications 2007;357(2):397-401.
2007: Seppo Rönkkö; Petri Rekonen; Kai Kaarniranta; Tuomo Puustjärvi; Markku Teräsvirta; Hannu Uusitalo
Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2007;245(5):697-704.
2007: Niku K J Oksala; Jani Lappalainen; David E Laaksonen; Savita Khanna; Kai Kaarniranta; Chandan K Sen; Mustafa Atalay
Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.
Antioxidants & redox signaling 2007;9(4):497-506.
2007: Elisa Toropainen; Margit Hornof; Kai Kaarniranta; Pinja Johansson; Arto Urtti
Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops.
The journal of gene medicine 2007;9(3):208-16.
2007: Kai Kaarniranta; Juha M Holopainen; Matti K Karvonen; Markku Koulu; Jaana Kallio; Ullamari Pesonen; Markku Teräsvirta; Hannu Uusitalo; Ilkka Immonen
Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration.
Acta ophthalmologica Scandinavica 2007;85(2):188-91.
2007: Eliisa Mannermaa; Arto Urtti; Kai Kaarniranta
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2007;123(18):2229-37.
2007: Seppo Rönkkö; Petri Rekonen; Kai Kaarniranta; Tuomo Puustjarvi; Markku Teräsvirta; Hannu Uusitalo
Phospholipase A2 in chamber angle of normal eyes and patients with primary open angle glaucoma and exfoliation glaucoma.
Molecular vision 2007;13():408-17.
2007: Kai Kaarniranta; Kaija Tuppurainen; Kari Nikolajev
Maculopathy in Pierre Robin sequences.
Journal of pediatric ophthalmology and strabismus 2007;44(1):10-1.
2006: Marko Määttä; Taina Tervahartiala; Kai Kaarniranta; Yi Tang; Li Yan; Juha Tuukkanen; Timo Sorsa
Immunolocalization of EMMPRIN (CD147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids.
Current eye research 2006;31(11):917-24.
2006: Kai Kaarniranta; Tapio Ihanamäki; Janne Sahlman; Hertta Pulkkinen; Hannu Uusitalo; Machiko Arita; Raija Tammi; Mikko Juhani Lammi; Heikki J Helminen
A mouse model for Stickler's syndrome: ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1).
Experimental eye research 2006;83(2):297-303.
2006: Sanna Seitsonen; Susanna Lemmelä; Juha M Holopainen; Petri Tommila; Päivi Ranta; Antti Kotamies; Jukka A O Moilanen; Tapani Palosaari; Kai Kaarniranta; Seppo Meri; Ilkka Immonen; Irma Järvelä
Analysis of variants in the complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degeneration in the Finnish population.
Molecular vision 2006;12():796-801.
2005: Kai Kaarniranta; Tuomas Ryhänen; Hannu M Karjalainen; Mikko Juhani Lammi; Tiina Suuronen; Anne Huhtala; Matti Kontkanen; Markku Teräsvirta; Hannu Uusitalo; Antero Salminen
Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells.
Neuroscience letters 2005;382(1-2):185-90.
2005: Kai Kaarniranta; Tuomas Ryhänen; Reijo K Sironen; Tiina Suuronen; Mika A Elo; Hannu M Karjalainen; Mikko Juhani Lammi; Markku Teräsvirta; Hannu Uusitalo; Antero Salminen
Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells.
Brain research. Molecular brain research 2005;137(1-2):126-31.
2005: Mika A Elo; Kai Kaarniranta; Heikki J Helminen; Mikko Juhani Lammi
Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure.
Biochimica et biophysica acta 2005;1743(1-2):115-9.
2004: Mikko Juhani Lammi; Mika A Elo; Reijo K Sironen; Hannu M Karjalainen; Kai Kaarniranta; Heikki J Helminen
Hydrostatic pressure-induced changes in cellular protein synthesis.
Biorheology 2004;41(3-4):309-13.
2003: Kai Kaarniranta; Matti Kontkanen
Visual recovery of the amblyopic eye in an adult patient after loss of the dominant eye.
Acta ophthalmologica Scandinavica 2003;81(5):539.
2003: Kai Kaarniranta; Roope K Sihvola; Antero Salminen; Mikko Juhani Lammi; Markku Teräsvirta; Matti Kontkanen
[Age-related macular degeneration--a difficult problem for the patient and for the ophthalmologist].
Duodecim; lääketieteellinen aikakauskirja 2003;119(10):935-42.
2003: Mika A Elo; Reijo K Sironen; Hannu M Karjalainen; Kai Kaarniranta; Heikki J Helminen; Mikko Juhani Lammi
Specific induction of heat shock protein 90beta by high hydrostatic pressure.
Biorheology 2003;40(1-3):141-6.
2003: Hannu M Karjalainen; Reijo K Sironen; Mika A Elo; Kai Kaarniranta; Masaharu Takigawa; Heikki J Helminen; Mikko Juhani Lammi
Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study.
Biorheology 2003;40(1-3):93-100.
2003: Kai Kaarniranta; Mika A Elo; Reijo K Sironen; Hannu M Karjalainen; Heikki J Helminen; Mikko Juhani Lammi
Stress responses of mammalian cells to high hydrostatic pressure.
Biorheology 2003;40(1-3):87-92.
2002: Niku K J Oksala; Kai Kaarniranta; Jyrki J Tenhunen; R Tiihonen; Antero Heino; Lea Sistonen; Hannu Paimela; Esko Alhava
Reperfusion but not acute ischemia in pig small intestine induces transcriptionally mediated heat shock response in situ.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2002;34(6):397-404.
2002: Reijo K Sironen; Hannu M Karjalainen; Mika A Elo; Kai Kaarniranta; Kari Törrönen; Masaharu Takigawa; Heikki J Helminen; Mikko Juhani Lammi
cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure.
Biochimica et biophysica acta 2002;1591(1-3):45-54.
2002: Kai Kaarniranta; Niku K J Oksala; Hannu M Karjalainen; Tiina Suuronen; Lea Sistonen; Heikki J Helminen; Antero Salminen; Mikko Juhani Lammi
Neuronal cells show regulatory differences in the hsp70 gene response.
Brain research. Molecular brain research 2002;101(1-2):136-40.
2002: Reijo K Sironen; Hannu M Karjalainen; Kari Törrönen; Mika A Elo; Kai Kaarniranta; Masaharu Takigawa; Heikki J Helminen; Mikko Juhani Lammi
High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis.
Biorheology 2002;39(1-2):111-7.
2001: Kai Kaarniranta; Niku K J Oksala; Mikko Juhani Lammi; Heikki J Helminen; Lea Sistonen
[From research of cellular stress to various clinical break through innovations?].
Duodecim; lääketieteellinen aikakauskirja 2001;117(22):2266-72.
2001: Kai Kaarniranta; C I Holmberg; Mikko Juhani Lammi; John E Eriksson; Lea Sistonen; Heikki J Helminen
Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(1):7-13.
2000: Mika A Elo; Reijo K Sironen; Kai Kaarniranta; S Auriola; Heikki J Helminen; Mikko Juhani Lammi
Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytic cells.
Journal of cellular biochemistry 2000;79(4):610-9.
2000: Kai Kaarniranta; C I Holmberg; Heikki J Helminen; John E Eriksson; Lea Sistonen; Mikko Juhani Lammi
Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature.
FEBS letters 2000;475(3):283-6.
2000: Reijo K Sironen; Mika A Elo; Kai Kaarniranta; Heikki J Helminen; Mikko Juhani Lammi
Transcriptional activation in chondrocytes submitted to hydrostatic pressure.
Biorheology 2000;37(1-2):85-93.
1998: Tero-Pekka Alastalo; M Lönnström; Sirpa Leppä; Kai Kaarniranta; Markku Pelto-Huikko; Lea Sistonen; Martti Parvinen
Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium.
Experimental cell research 1998;240(1):16-27.
1998: Kai Kaarniranta; Mika A Elo; Reijo K Sironen; Mikko Juhani Lammi; M B Goldring; John E Eriksson; Lea Sistonen; Heikki J Helminen
Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2319-24.