Peter Kador

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Kador Peter F; Randazzo James; Blessing Karen; Makita Jun; Zhang Peng; Yu Kuang; Hosoya Ken-Ichi; Terasaki T
Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB).
Drel Viktor R; Xu Weizheng; Zhang Jie; Kador Peter F; Ali Tayyeba K; Shin Jeho; Julius Ulrich; Slusher Barbara; El-Remessy Azza B; Obrosova Irina G
Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats.
Kador P F; Wyman M
Asteroid hyalosis: pathogenesis and prospects for prevention.

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2009: Kador Peter F; Randazzo James; Blessing Karen; Makita Jun; Zhang Peng; Yu Kuang; Hosoya Ken-Ichi; Terasaki T
Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB).
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2009;25(4):299-308.
2009: Drel Viktor R; Xu Weizheng; Zhang Jie; Kador Peter F; Ali Tayyeba K; Shin Jeho; Julius Ulrich; Slusher Barbara; El-Remessy Azza B; Obrosova Irina G
Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats.
Investigative ophthalmology & visual science 2009;50(4):1778-90.
2008: Kador P F; Wyman M
Asteroid hyalosis: pathogenesis and prospects for prevention.
Eye (London, England) 2008;22(10):1278-85.
2007: Kador Peter F; Blessing Karen; Randazzo James; Makita Jun; Wyman Milton
Evaluation of the vascular targeting agent combretastatin a-4 prodrug on retinal neovascularization in the galactose-fed dog.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2007;23(2):132-42.
2007: Kador Peter F; Randazzo James; Babb Thomas; Koushik Kavitha; Takamura Yoshihiro; Zhu Wenjun; Blessing Karen; Kompella Uday B
Topical aldose reductase inhibitor formulations for effective lens drug delivery in a rat model for sugar cataracts.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2007;23(2):116-23.
2007: Kador Peter F; Takahashi Yukio; Akagi Yoshio; Blessing Karen; Randazzo James; Wyman Milton
Age-dependent retinal capillary pericyte degeneration in galactose-fed dogs.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2007;23(1):63-9.
2007: Mulhern Michael L; Madson Christian J; Kador Peter F; Randazzo James; Shinohara Toshimichi
Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats.
Molecular vision 2007;13():1397-405.
2006: Ikesugi Kengo; Mulhern Michael L; Madson Christian J; Hosoya Ken-Ichi; Terasaki Tetsuya; Kador Peter F; Shinohara Toshimichi
Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation.
Current eye research 2006;31(11):947-53.
2006: Kador Peter F; Betts Daniel; Wyman Milton; Blessing Karen; Randazzo James
Effects of topical administration of an aldose reductase inhibitor on cataract formation in dogs fed a diet high in galactose.
American journal of veterinary research 2006;67(10):1783-7.
2006: Toris Carol B; Lane James T; Akagi Yoshio; Blessing Karen A; Kador Peter F
Aqueous flow in galactose-fed dogs.
Experimental eye research 2006;83(4):865-70.
2006: Mulhern Michael L; Madson Christian J; Danford Andrew; Ikesugi Kengo; Kador Peter F; Shinohara Toshimichi
The unfolded protein response in lens epithelial cells from galactosemic rat lenses.
Investigative ophthalmology & visual science 2006;47(9):3951-9.
2006: Wang Mingan; Kador Peter F; Wyman Milton
Structure of asteroid bodies in the vitreous of galactose-fed dogs.
Molecular vision 2006;12():283-9.
2005: Wang Mingan; Mishra Manoj K; Zhu Wenjun; Kador Peter F
Spectral assignments for the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4,4'-imidazoline]-2',5'-dione and its synthetic intermediates.
Magnetic resonance in chemistry : MRC 2005;43(12):1008-11.
2004: Sun G; Ma Y; Gao X; König S; Fales H M; Kador P F
Method for isolating tight-binding inhibitors of rat lens aldose reductase.
Experimental eye research 2004;79(6):919-26.
2004: Kador Peter F; Inoue Jun; Blessing Karen
Anticataract activity of analogs of a sorbitol dehydrogenase inhibitor.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2004;20(4):333-44.
2004: Lim Sun-Woo; Li Can; Sun Bo-Kyung; Han Ki-Hwan; Kim Wan-Young; Oh Yoon-Wha; Lee Jong-Un; Kador Peter F; Knepper Mark A; Sands Jeff M; Kim Jin; Yang Chul-Woo
Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney.
American journal of physiology. Renal physiology 2004;287(1):F139-51.
2003: Cusick Michael; Chew Emily Y; Ferris Frederick; Cox Terry A; Chan Chi-Chao; Kador Peter F
Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs.
Archives of ophthalmology 2003;121(12):1745-51.
2003: Zatechka D Steven; Kador Peter F; Garcia-Castiñeiras Sixto; Lou Marjorie F
Diabetes can alter the signal transduction pathways in the lens of rats.
Diabetes 2003;52(4):1014-22.
2003: Lee Yong S; Hodoscek Milan; Kador Peter F; Sugiyama Katsumi
Hydrogen bonding interactions between aldose reductase complexed with NADP(H) and inhibitor tolrestat studied by molecular dynamics simulations and binding assay.
Chemico-biological interactions 2003;143-144():307-16.
2002: Murata M; Ohta N; Fujisawa S; Tsai J-Y; Sato S; Akagi Y; Takahashi Y; Neuenschwander H; Kador P F
Selective pericyte degeneration in the retinal capillaries of galactose-fed dogs results from apoptosis linked to aldose reductase-catalyzed galactitol accumulation.
Journal of diabetes and its complications 2002;16(5):363-70.
2002: Kador Peter F; Takahashi Yukio; Akagi Yoshio; Neuenschwander Heike; Greentree William; Lackner Petra; Blessing Karen; Wyman Milton
Effect of galactose diet removal on the progression of retinal vessel changes in galactose-fed dogs.
Investigative ophthalmology & visual science 2002;43(6):1916-21.
2002: Kawamura Minoru; Eisenhofer Graeme; Kopin Irwin J; Kador Peter F; Lee Yong S; Fujisawa Shigeki; Sato Sanai
Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia.
Autonomic neuroscience : basic & clinical 2002;96(2):131-9.
2001: Lizak M J; Mori K; Kador P F
Determination of aldose reductase activity in the eye by localized magnetic resonance spectroscopy.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2001;17(5):475-83.
2001: Kador P F; Sun G; Rait V K; Rodriguez L; Ma Y; Sugiyama K
Intrinsic inhibition of aldose reductase.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2001;17(4):373-81.
2001: Murata M; Ohta N; Sakurai S; Alam S; Tsai J; Kador P F; Sato S
The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis).
Chemico-biological interactions 2001;130-132(1-3):617-25.
2000: Lizak M J; Datiles M B; Aletras A H; Kador P F; Balaban R S
MRI of the human eye using magnetization transfer contrast enhancement.
Investigative ophthalmology & visual science 2000;41(12):3878-81.
2000: Murata M; Kador P F; Sato S
Vascular endothelial growth factor (VEGF) enhances the expression of receptors and activates mitogen-activated protein (MAP) kinase of dog retinal capillary endothelial cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2000;16(4):383-91.
2000: Kador P F; Lee J W; Fujisawa S; Blessing K; Lou M F
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2000;16(2):149-60.
2000: Sugiyama K; Chen Z; Lee Y S; Kador P F
Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex.
Biochemical pharmacology 2000;59(4):329-36.
1999: Kawamura M; Eisenhofer G; Kopin I J; Kador P F; Lee Y S; Tsai J Y; Fujisawa S; Lizak M J; Sinz A; Sato S
Aldose reductase, a key enzyme in the oxidative deamination of norepinephrine in rats.
Biochemical pharmacology 1999;58(3):517-24.
1999: Ohta N; Tsai J Y; Secchi E F; Kador P F; Sato S
Neutrophils in galactose-fed dogs: suppressed apoptosis and increased adhesion to retinal capillary endothelial cells.
Journal of diabetes and its complications 1999;13(3):151-8.
1999: Sato S; Sugiyama K; Lee Y S; Kador P F
Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors.
Experimental eye research 1999;68(5):601-8.
1999: Secchi E F; Lizak M J; Sato S; Kador P F
3-Fluoro-3-deoxy-D-galactose: a new probe for studies on sugar cataract.
Current eye research 1999;18(4):277-82.
1999: Sato S; Secchi E F; Lizak M J; Fukase S; Ohta N; Murata M; Tsai J Y; Kador P F
Polyol formation and NADPH-dependent reductases in dog retinal capillary pericytes and endothelial cells.
Investigative ophthalmology & visual science 1999;40(3):697-704.
1999: Caspers-Velu L E; Wadhwani K C; Rapoport S I; Kador P F
Iris vasculopathy in galactose-fed rats.
Experimental eye research 1999;68(2):211-21.
1999: Datiles M B; Kador P F
Type I diabetic cataract.
Archives of ophthalmology 1999;117(2):284-5.
1999: Sugiyama K; Wang T C; Simpson J T; Rodriguez L; Kador P F; Sato S
Aldose reductase catalyzes the oxidation of naphthalene-1, 2-dihydrodiol for the formation of ortho-naphthoquinone.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(1):60-7.
1999: Lee Y S; Sugiyama K; Kador P F
Rotamers of tolrestat and their binding mode to aldose reductase.
Advances in experimental medicine and biology 1999;463():465-72.
1999: Sato S; Kawamura M; Eisenhofer G; Kopin I J; Fujisawa S; Kador P F
Aldo-keto reductases in norepinephrine metabolism.
Advances in experimental medicine and biology 1999;463():459-63.
1998: Lizak M J; Secchi E F; Lee J W; Sato S; Kubo E; Akagi Y; Kador P F
3-FG as substrate for investigating flux through the polyol pathway in dog lens by 19F-NMR spectroscopy.
Investigative ophthalmology & visual science 1998;39(13):2688-95.
1998: Lee Y S; Chen Z; Kador P F
Molecular modeling studies of the binding modes of aldose reductase inhibitors at the active site of human aldose reductase.
Bioorganic & medicinal chemistry 1998;6(10):1811-9.
1998: Kador P F; Inoue J; Secchi E F; Lizak M J; Rodriguez L; Mori K; Greentree W; Blessing K; Lackner P A; Sato S
Effect of sorbitol dehydrogenase inhibition on sugar cataract formation in galactose-fed and diabetic rats.
Experimental eye research 1998;67(2):203-8.
1998: Lee Y S; Hodoscek M; Brooks B R; Kador P F
Catalytic mechanism of aldose reductase studied by the combined potentials of quantum mechanics and molecular mechanics.
Biophysical chemistry 1998;70(3):203-16.
1998: Sato S; Mori K; Wyman M; Kador P F
Dose-dependent prevention of sugar cataracts in galactose-fed dogs by the aldose reductase inhibitor M79175.
Experimental eye research 1998;66(2):217-22.
1997: Neuenschwander H; Takahashi Y; Kador P F
Dose-dependent reduction of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by the aldose reductase inhibitor M79175.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1997;13(6):517-28.
1997: Kawamura M; Kopin I J; Kador P F; Sato S; Tjurmina O; Eisenhofer G
Effects of aldehyde/aldose reductase inhibition on neuronal metabolism of norepinephrine.
Journal of the autonomic nervous system 1997;66(3):145-8.
1997: Lackner P A; Rodriguez L; Sato S; Lizak M J; Wyman M; Kador P F
Age-dependent lens changes in galactose-fed dogs.
Experimental eye research 1997;64(3):431-6.
1996: Fukase S; Sato S; Mori K; Secchi E F; Kador P F
Polyol pathway and NADPH-dependent reductases in dog leukocytes.
Journal of diabetes and its complications 1996;10(6):304-13.
1996: Lizak M J; Mori K; Ceckler T L; Balaban R S; Kador P F
Quantitation of galactosemic cataracts in dogs using magnetization transfer contrast-enhanced magnetic resonance imaging.
Investigative ophthalmology & visual science 1996;37(11):2219-27.
1996: Schaffhauser M A; Sato S; Kador P F
NADPH-dependent reductases in dog thyroid: comparison of a third enzyme "glyceraldehyde reductase" to dog thyroid aldehyde reductase.
The international journal of biochemistry & cell biology 1996;28(3):275-84.
1995: Mori K; Lizak M J; Ceckler T L; Balaban R S; Kador P F
Magnetic resonance imaging of the galactosemic dog eye using magnetization transfer contrast.
Current eye research 1995;14(11):1035-40.
1995: Kador P F; Lee Y S; Rodriguez L; Sato S; Bartoszko-Malik A; Abdel-Ghany Y S; Miller D D
Identification of an aldose reductase inhibitor site by affinity labeling.
Bioorganic & medicinal chemistry 1995;3(10):1313-24.
1995: Neuenschwander H; Julia C; Wyman M; Kador P F
Endothelial changes in galactose-fed dogs.
Current eye research 1995;14(4):319-22.
1995: Kador P F; Takahashi Y; Wyman M; Ferris F
Diabeteslike proliferative retinal changes in galactose-fed dogs.
Archives of ophthalmology 1995;113(3):352-4.
1995: Caspers-Velu L E; Wadhwani K C; Rapoport S I; Kador P F
Permeability of the blood-retinal and blood-aqueous barriers in galactose-fed rats.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1995;11(3):469-87.
1995: Sato S; Old S; Carper D; Kador P F
Purification and characterization of recombinant human placental and rat lens aldose reductases expressed in Escherichia coli.
Advances in experimental medicine and biology 1995;372():259-68.
1994: Kador P F; Takahashi Y; Sato S; Wyman M
Amelioration of diabetes-like retinal changes in galactose-fed dogs.
Preventive medicine 1994;23(5):717-21.
1994: Lee Y S; Pearlstein R; Kador P F
Molecular modeling studies of aldose reductase inhibitors.
Journal of medicinal chemistry 1994;37(6):787-92.
1993: Li Q; Lopez J S; Caspi R R; Roberge F G; Nussenblatt R B; Kador P F; Chan C C
Suppression of S-antigen-induced experimental autoimmune uveoretinitis in Lewis rats by oral administration with CGS-13080, a thromboxane synthetase inhibitor.
Experimental eye research 1993;57(5):601-8.
1993: Sato S; Lin L R; Reddy V N; Kador P F
Aldose reductase in human retinal pigment epithelial cells.
Experimental eye research 1993;57(2):235-41.
1993: Sato S; Kador P F
Human kidney aldose and aldehyde reductases.
Journal of diabetes and its complications 1993;7(3):179-87.
1993: Takahashi Y; Augustin W; Wyman M; Kador P F
Quantitative analysis of retinal vessel changes in galactose-fed dogs.
Journal of ocular pharmacology 1993;9(3):257-69.
1992: Takahashi Y; Wyman M; Ferris F; Kador P F
Diabeteslike preproliferative retinal changes in galactose-fed dogs.
Archives of ophthalmology 1992;110(9):1295-302.
1992: Reddy V N; Lin L R; Giblin F J; Lou M; Kador P F; Kinoshita J H
The efficacy of aldose reductase inhibitors on polyol accumulation in human lens and retinal pigment epithelium in tissue culture.
Journal of ocular pharmacology 1992;8(1):43-52.
1991: Sato S; Takahashi Y; Wyman M; Kador P F
Progression of sugar cataract in the dog.
Investigative ophthalmology & visual science 1991;32(6):1925-31.
1991: Lin L R; Reddy V N; Giblin F J; Kador P F; Kinoshita J H
Polyol accumulation in cultured human lens epithelial cells.
Experimental eye research 1991;52(1):93-100.
1991: Mizoguchi T; Itabe H; Kador P F
Reactivity of enzyme modification reagents with aldose reductase and aldehyde reductase.
Advances in experimental medicine and biology 1991;284():205-16.
1991: Carper D; Sato S; Old S; Chung S; Kador P F
In vitro expression of human placental aldose reductase in Escherichia coli.
Advances in experimental medicine and biology 1991;284():129-38.
1990: Datiles M B; Kador P F; Kashima K; Kinoshita J H; Sinha A
The effects of sorbinil, an aldose reductase inhibitor, on the corneal endothelium in galactosemic dogs.
Investigative ophthalmology & visual science 1990;31(11):2201-4.
1990: Kador P F; Akagi Y; Takahashi Y; Ikebe H; Wyman M; Kinoshita J H
Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors.
Archives of ophthalmology 1990;108(9):1301-9.
1990: Sato S; Kador P F
Inhibition of aldehyde reductase by aldose reductase inhibitors.
Biochemical pharmacology 1990;40(5):1033-42.
1990: Old S E; Sato S; Kador P F; Carper D A
In vitro expression of rat lens aldose reductase in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):4942-5.
1990: Sato S; Kador P F
NADPH-dependent reductases of the dog lens.
Experimental eye research 1990;50(6):629-34.
1990: Kador P F
The contributions of Jin H. Kinoshita to aldose reductase research.
Experimental eye research 1990;50(6):615-20.
1990: Tanimoto T; Sato S; Kador P F
Purification and properties of aldose reductase and aldehyde reductase from EHS tumor cells.
Biochemical pharmacology 1990;39(3):445-53.
1989: Wadhwani K C; Caspers-Velu L E; Murphy V A; Smith Q R; Kador P F; Rapoport S I
Prevention of nerve edema and increased blood-nerve barrier permeability-surface area product in galactosemic rats by aldose reductase or thromboxane synthetase inhibitors.
Diabetes 1989;38(11):1469-77.
1989: Terubayashi H; Sato S; Nishimura C; Kador P F; Kinoshita J H
Localization of aldose and aldehyde reductase in the kidney.
Kidney international 1989;36(5):843-51.
1989: Sato S; Kador P F
Rat lens aldehyde reductase.
Investigative ophthalmology & visual science 1989;30(7):1618-22.
1989: Nakayama T; Tanimoto T; Kador P F
Human erythrocyte aldose and aldehyde reductase.
Progress in clinical and biological research 1989;290():265-77.
1989: Kador P F; Nakayama T; Sato S; Smar M; Miller D D
What is the nature of the charge transfer interaction at the aldose reductase inhibitor site.
Progress in clinical and biological research 1989;290():237-50.
1988: Wyman M; Sato S; Akagi Y; Terubayashi H; Datiles M; Kador P F
The dog as a model for ocular manifestations of high concentrations of blood sugars.
Journal of the American Veterinary Medical Association 1988;193(9):1153-6.
1988: Kador P F; Akagi Y; Terubayashi H; Wyman M; Kinoshita J H
Prevention of pericyte ghost formation in retinal capillaries of galactose-fed dogs by aldose reductase inhibitors.
Archives of ophthalmology 1988;106(8):1099-102.
1988: Kador P F
The role of aldose reductase in the development of diabetic complications.
Medicinal research reviews 1988;8(3):325-52.
1987: Lightman S; Rechthand E; Terubayashi H; Palestine A; Rapoport S; Kador P
Permeability changes in blood-retinal barrier of galactosemic rats are prevented by aldose reductase inhibitors.
Diabetes 1987;36(11):1271-5.

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Peter Kador

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