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Takashi Kadowaki

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Takumi Matsumoto; Yuichi Nagase; Kozo Nakamura; Jun Hirose; Yuho Kadono; Takashi Kadowaki; Naoto Tokuyama; Kohjiro Ueki; Tetsuro Yasui; Sakae Tanaka
Regulation of bone resorption and sealing zone formation in osteoclasts occurs through protein kinase b-mediated microtubule stabilization.
Toshimasa Yamauchi; Takashi Kadowaki
Adiponectin receptor as a key player in healthy longevity and obesity-related diseases.
Toshimasa Yamauchi; Takashi Kadowaki
[Adipocytokines].

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2013: Takumi Matsumoto; Yuichi Nagase; Kozo Nakamura; Jun Hirose; Yuho Kadono; Takashi Kadowaki; Naoto Tokuyama; Kohjiro Ueki; Tetsuro Yasui; Sakae Tanaka
Regulation of bone resorption and sealing zone formation in osteoclasts occurs through protein kinase b-mediated microtubule stabilization.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(5):1191-202.
2013: Toshimasa Yamauchi; Takashi Kadowaki
Adiponectin receptor as a key player in healthy longevity and obesity-related diseases.
Cell metabolism 2013;17(2):185-96.
2013: Toshimasa Yamauchi; Takashi Kadowaki
[Adipocytokines].
Nihon rinsho. Japanese journal of clinical medicine 2013;71(2):251-6.
2013: Kayo Waki; Masaru Hirata; Takashi Kadowaki; Junichi Kaneko; Koichi Mizuta; Masumi Nozawa; Miyuki Ozawa; Yasuhiko Sugawara; Koki Takahashi; Michiko Taniguchi; Paul I Terasaki; Norihiro Kokudo
Predicting operational tolerance in pediatric living-donor liver transplantation by absence of HLA antibodies.
Transplantation 2013;95(1):177-83.
2013: Tomohide Yamada; Hitomi Umematsu; Kazuo Hara; Takashi Kadowaki
Male pattern baldness and its association with coronary heart disease: a meta-analysis.
BMJ open 2013;3(4):.
2013: Makoto Oe; Yumiko Ohashi; Hiromi Sanada; Kohjiro Ueki; Takahumi Kadono; Takeo Minematsu; Takashi Nagase; Takashi Kadowaki
Sweat gland atrophy of the heel in diabetic patients with angiopathy.
Journal of clinical nursing 2013;22(1-2):289-92.
2012: Hironori Waki; Toshimasa Yamauchi; Takashi Kadowaki
The epigenome and its role in diabetes.
Current diabetes reports 2012;12(6):673-85.
2012: Hayato Fujita; Kazuo Hara; Yushi Hirota; Momoko Horikoshi; Minoru Iwata; Susumu Seino; Nobuhiro Shojima; Kazuyuki Tobe; Takashi Kadowaki
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits.
Journal of human genetics 2012;57(12):776-9.
2012: Y Nio; M Okada-Iwabu; Keisuke Ueki; Mitsuko Yamaguchi; Toshimasa Yamauchi; M Funata; M Iwabu; Takashi Kadowaki
Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice.
Diabetologia 2012;55(12):3350-8.
2012: Nobuhiro Shojima; N Takahashi; Iseki Takamoto; Keisuke Ueki; Toshimasa Yamauchi; Hiroyuki Aburatani; H Fujita; K Hara; M Horikoshi; Naoto Kubota; M Noda; Miho Ohsugi; Takashi Kadowaki
Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice.
Diabetologia 2012;55(12):3318-30.
2012: A Nakamura; Y Nozaki; K Sato; K Tajima; M Yoneda; K Zolzaya; K Fujita; H Haga; R Inoue; Takashi Kadowaki; K C Kubota; Naoto Kubota; S Maeda; Y Nagashima; A Nakajima; Yasuo Terauchi
Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance.
Diabetologia 2012;55(12):3382-91.
2012: Miki Okada-Iwabu; Toshimasa Yamauchi; Takashi Kadowaki
[New drug targets for the metabolic syndrome and obesity].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():372-7.
2012: Sayaka Shibata; Yayoi Tada; Toshimasa Yamauchi; Yoshihide Asano; Carren S Hau; Takashi Kadowaki; Toyoaki Kato; Naoto Kubota; Hidehisa Saeki; Shinichi Sato
Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(6):3231-41.
2012: Kayo Waki; Koji Omae; Yuji Uchimura; Eiji Aramaki; Hideo Fujita; Takashi Kadowaki; Kazuhiko Ohe
DialBetics: smartphone-based self-management for type 2 diabetes patients.
Journal of diabetes science and technology 2012;6(4):983-5.
2012: Naoko Yamauchi; Toshimasa Yamauchi; Takashi Hibiya; Masato Iwabu; Takashi Kadowaki; Daichi Maeda; Miki Okada-Iwabu; Yutaka Takazawa; Mariko Tanaka; Masashi Fukayama
Expression levels of adiponectin receptors are decreased in human endometrial adenocarcinoma tissues.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2012;31(4):352-7.
2012: Jun Shirakawa; Kazuki Tajima; Ritsuko Tanami; Yoshio Goshima; Takashi Kadowaki; Naoto Kubota; Kazuki Orime; Yu Togashi; Yasuo Terauchi
Effects of liraglutide on β-cell-specific glucokinase-deficient neonatal mice.
Endocrinology 2012;153(7):3066-75.
2012: A Nakamura; M Ohsugi; K Orime; K Sato; J Shirakawa; Takashi Kadowaki; Naoto Kubota; Y Togashi; Yasuo Terauchi
Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions.
Diabetologia 2012;55(6):1745-54.
2012: Makoto Oe; Yumiko Ohashi; Hiromi Sanada; Kohjiro Ueki; Takahumi Kadono; Takeo Minematsu; Takashi Nagase; Takashi Kadowaki
Factors associated with deep foot fissures in diabetic patients: a cross-sectional observational study.
International journal of nursing studies 2012;49(6):739-46.
2012: Miki Okada-Iwabu; Toshimasa Yamauchi; Takashi Kadowaki
[Functional food component--osmotin].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():746-9.
2012: Takashi Kadowaki
[Disease concept of type 2 diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():375-82.
2012: Toshimasa Yamauchi; Takashi Kadowaki
[Pathophysiological roles of adipocytokines in the development of insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():166-74.
2012: Takashi Kadowaki
[Action plan 2010 of Japan Diabetes Society (DREAMS)].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():51-9.
2012: Kosei Eguchi; Takashi Kadowaki; Masao Kimoto; Nozomu Kono; Ichiro Manabe; Kensuke Miyake; Fusa Ogata; Miho Ohsugi; Umeharu Ohto; Yumiko Oishi-Tanaka; Kazuyuki Tobe; Nobuhiro Yagi; Hiroyuki Arai; Ryozo Nagai
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation.
Cell metabolism 2012;15(4):518-33.
2012: Koichiro Sato; Kazuaki Shinoda; Jun Shirakawa; Takashi Kadowaki; Naoto Kubota; Tomonori Muraoka; Akinobu Nakamura; Kazuki Orime; Yu Togashi; Yasuo Terauchi
Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and β-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet.
Endocrinology 2012;153(3):1093-102.
2012: Takashi Kadowaki; Naoto Kubota; Kohjiro Ueki; Toshimasa Yamauchi
SnapShot: physiology of insulin signaling.
Cell 2012;148(4):834-834.e1.
2012: Takashi Kadowaki; Kohjiro Ueki; Toshimasa Yamauchi; Naoto Kubota
SnapShot: Insulin signaling pathways.
Cell 2012;148(3):624, 624.e1.
2012: Sunghee Lee; Kamal Masaki; Katsuyuki Miura; Teruo Otake; Todd Seto; Chol Shin; Tomoko Takamiya; Hirotsugu Ueshima; Jina Choo; J David Curb; Daniel Edmundowicz; Aiman El-Saed; Rhobert W Evans; Akira Fujiyoshi; Sayaka Kadowaki; Takashi Kadowaki; Lewis H Kuller; Akira Sekikawa
Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1.
The British journal of nutrition 2012;107(4):567-72.
2012: Tomohide Yamada; Kazuo Hara; Ryo Suzuki; Hitomi Umematsu; Takashi Kadowaki
Erectile dysfunction and cardiovascular events in diabetic men: a meta-analysis of observational studies.
PloS one 2012;7(9):e43673.
2012: Takashi Kadowaki; Tetsuya Ohtani; Masato Odawara
Potential formula for the calculation of starting and incremental insulin glargine doses: ALOHA subanalysis.
PloS one 2012;7(8):e41358.
2012: Tomohide Yamada; Kazuo Hara; Takashi Kadowaki
Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies.
PloS one 2012;7(7):e42031.
2011: Keisuke Kataoka; Hiroshi Kobayashi; Naoto Kubota; Katsuyoshi Kumagai; Keiki Kumano; Shunya Arai; Susumu Goyama; Yoichi Imai; Takashi Kadowaki; Masahiro Nakagawa; Tomohiko Sato; Munetake Shimabe; Takako Tsuruta; Akihide Yoshimi; Mineo Kurokawa
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity.
The Journal of experimental medicine 2011;208(12):2403-16.
2011: Hironori Waki; Toshimasa Yamauchi; Jing Yu; Hiroyuki Aburatani; Tomohisa Aoyama; Takanori Fujita; Lisa Hirose-Yotsuya; Masato Iwabu; Tatsuhiko Kodama; Masahiro Nakamura; Miki Okada-Iwabu; Juro Sakai; Wei Sun; Kazumi Take; Shuichi Tsutsumi; Kohjiro Ueki; Ken-ichi Wakabayashi; Takashi Kadowaki
Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation.
PLoS genetics 2011;7(10):e1002311.
2011: Takashi Kadowaki
[108th Scientific Meeting of the Japanese Society of Internal Medicine: invited lecture: 4. Molecular mechanism and treatment strategy of type 2 diabetes].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2011;100(9):2437-46.
2011: Kayo Waki; Takashi Kadowaki
[Intensive glucose control and cardiovascular outcomes in diabetes and impaired glucose tolerance].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 7():573-8.
2011: Akira Sekikawa; Kim Sutton-Tyrrell; Hirotsugu Ueshima; Robert D Abbott; Jina Choo; J David Curb; Daniel Edmundowicz; Aiman El-Saed; Rhobert W Evans; Aya Kadota; Takashi Kadowaki; Lewis H Kuller; Kenichi Mitsunami; Katsuyuki Miura; Yasuyuki Nakamura; Katsumi Nakata; Yoshihiko Nishio; Tomonori Okamura; Teruo Otake
Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness.
Stroke; a journal of cerebral circulation 2011;42(9):2538-43.
2011: Kimie Takehara; Kazuhisa Tsukamoto; Yuichiro Tsunemi; Kohjiro Ueki; Shinji Iizaka; Takashi Kadowaki; Takashi Nagase; Makoto Oe; Yumiko Ohashi; Hiromi Sanada
Factors associated with presence and severity of toenail onychomycosis in patients with diabetes: a cross-sectional study.
International journal of nursing studies 2011;48(9):1101-8.
2011: Jun Kurokawa; Satoko Arai; Takashi Kadowaki; Naoto Kubota; Hiromichi Nagano; Osamu Ohara; Toru Miyazaki
Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(29):12072-7.
2011: Takashi Nagase; Hiromi Sanada; Kimie Takehara; Makoto Oe; Shinji Iizaka; Y Ohashi; Miho Oba; Takashi Kadowaki; Gojiro Nakagami
Variations of plantar thermographic patterns in normal controls and non-ulcer diabetic patients: novel classification using angiosome concept.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2011;64(7):860-6.
2011: Akira Fujiyoshi; Takashi Kadowaki; Sayaka Kadowaki; Akira Sekikawa; Takayoshi Ohkubo; Katsuyuki Miura; Daniel Edmundowicz; Matthew J Budoff; Kiyoshi Murata; Kiang Liu; Hirotsugu Ueshima
Comparability in coronary artery calcium scores on CT scan between two community-based cohort studies.
International journal of cardiology 2011;149(2):244-5.
2011: Ritsuko Nagatomo; Yoshikazu Ono; Kojiro Ueki; Takashi Kadowaki; Makoto Kaneko; Nobuko Kanno; Kaoru Yuasa; Yutaka Yatomi
[Questionnaire survey of the POCT device antsense ROSE for blood glucose analysis on healthcare professionals--evaluation focused on preventive measures against cross-infections].
Rinsho byori. The Japanese journal of clinical pathology 2011;59(6):577-82.
2011: Yoko Iizuka; Ken Ohashi; Kazuhisa Tsukamoto; Kohjiro Ueki; Takashi Kadowaki
Education and management of diabetes at The University of Tokyo Hospital.
Journal of diabetes 2011;3(2):104-8.
2011: Ichiro Kusumi; Mitsukuni Murasaki; Keiichi Uemura; Yoshihito Atsumi; Naoki Hashimoto; Tadayuki Hayashishita; Minoru Honda; Koki Ito; Takashi Kadowaki; Tsukasa Koyama
Screening for diabetes using Japanese monitoring guidance in schizophrenia patients treated with second-generation antipsychotics: a cross-sectional study using baseline data.
Psychiatry and clinical neurosciences 2011;65(4):349-55.
2011: Yoko Endo; Masashi Suzuki; Hideomi Yamada; Shoko Horita; Motoei Kunimi; Osamu Yamazaki; Ayumi Shirai; Motonobu Nakamura; Naoyuki Iso-o; Yuehong Li; Masumi Hara; Kazuhisa Tsukamoto; Nobuo Moriyama; Akihiko Kudo; Hayato Kawakami; Toshimasa Yamauchi; Naoto Kubota; Takashi Kadowaki; Haruki Kume; Yutaka Enomoto; Yukio Homma; George Seki; Toshiro Fujita
Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPARγ-dependent nongenomic signaling.
Cell metabolism 2011;13(5):550-61.
2011: Miho Ohsugi; Takashi Kadowaki
[The use of new agents enhancing incretin effects for patients with diabetes in Japan].
Nihon rinsho. Japanese journal of clinical medicine 2011;69(5):771-94.
2011: Hironori Waki; Toshimasa Yamauchi; Takashi Kadowaki
[Adipocytes and bone metabolism].
Clinical calcium 2011;21(5):703-8.
2011: Tomonori Muraoka; Kazutaka Aoki; Tomoyuki Iwasaki; Kazuaki Shinoda; Akinobu Nakamura; Hiroyuki Aburatani; Shuuichi Mori; Kumpei Tokuyama; Naoto Kubota; Takashi Kadowaki; Yasuo Terauchi
Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet.
Metabolism: clinical and experimental 2011;60(5):617-28.
2011: Takashi Kadowaki
[Obesity: Progress in diagnosis and treatment; Topics, III. Obesity and its complications; 1. Obesity and diabetes].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2011;100(4):939-44.
2011: Motoharu Awazawa; Kohjiro Ueki; Kazunori Inabe; Toshimasa Yamauchi; Naoto Kubota; Kazuma Kaneko; Masatoshi Kobayashi; Aya Iwane; Takayoshi Sasako; Yukiko Okazaki; Miho Ohsugi; Iseki Takamoto; Satoshi Yamashita; Hiroshi Asahara; Shizuo Akira; Masato Kasuga; Takashi Kadowaki
Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.
Cell metabolism 2011;13(4):401-12.
2011: Naoki Kobayashi; Kohjiro Ueki; Yukiko Okazaki; Aya Iwane; Naoto Kubota; Miho Ohsugi; Motoharu Awazawa; Masatoshi Kobayashi; Takayoshi Sasako; K Kaneko; Miho Suzuki; Yoshitaka Nishikawa; Kazuo Hara; Kotaro Yoshimura; Isao Koshima; Susumu Goyama; Koji Murakami; Junko Sasaki; Ryozo Nagai; Mineo Kurokawa; Takehiko Sasaki; Takashi Kadowaki
Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(14):5753-8.
2011: Katsuyoshi Kumagai; Naoto Kubota; Toshiki I Saito; Takayoshi Sasako; Rumi Takizawa; Katsuko Sudo; Mineo Kurokawa; Takashi Kadowaki
Generation of transgenic mice on an NOD/SCID background using the conventional microinjection technique.
Biology of reproduction 2011;84(4):682-8.
2011: Iseki Takamoto; Takashi Kadowaki
[Treatment of diabetes mellitus with oral hypoglycemic agents].
Nihon rinsho. Japanese journal of clinical medicine 2011;69(3):563-72.
2011: Kohjiro Ueki; Takashi Kadowaki
The other sweet face of XBP-1.
Nature medicine 2011;17(3):246-8.
2011: Takashi Kadowaki; Toshimasa Yamauchi
Adiponectin receptor signaling: a new layer to the current model.
Cell metabolism 2011;13(2):123-4.
2011: Hideyuki Sakoda; Shizuo Ito; Hiroko Kanda; Midori Fujishiro; Jun-ichi Osuga; Kazuhisa Tsukamoto; Kohjiro Ueki; Takashi Kadowaki
Association between type 1 diabetes mellitus and remitting seronegative symmetrical synovitis with pitting edema: a case report.
Diabetes research and clinical practice 2011;91(2):e43-4.
2011: Keisuke Ohta; Motohiro Sekiya; Hiroshi Uozaki; Masaki Igarashi; Satoru Takase; Masayoshi Kumagai; Masakatsu Takanashi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Makiko Nishi; Hiroaki Okazaki; Yoko Iizuka; Naoya Yahagi; Hiroaki Yagyu; Masashi Fukayama; Takashi Kadowaki; Ken Ohashi; Shun Ishibashi; Jun-ichi Osuga
Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
Biochemical and biophysical research communications 2011;404(1):254-60.
2011: Takashi Kadowaki; M Okada-Iwabu; Hironori Waki; Toshimasa Yamauchi; M Iwabu; M Nakamura
Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis.
Cold Spring Harbor symposia on quantitative biology 2011;76():257-65.
2011: Makoto Kurano; Naoyuki Iso-o; Masumi Hara; Eisei Noiri; Kazuhiko Koike; Takashi Kadowaki; Kazuhisa Tsukamoto
Plant sterols increased IL-6 and TNF-α secretion from macrophages, but to a lesser extent than cholesterol.
Journal of atherosclerosis and thrombosis 2011;18(5):373-83.
2011: Dai Kawashima; Takayuki Ohno; Osamu Kinoshita; Noboru Motomura; Arihiro Kiyosue; Hideo Fujita; Jiro Ando; Kazuyoshi Ohtomo; Takashi Shigeeda; Satoshi Kato; Takashi Kadowaki; Ryozo Nagai; Shinichi Takamoto; Minoru Ono
Prevalence of vitreous hemorrhage following coronary revascularization in patients with diabetic retinopathy.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(2):329-35.
2010: Kazuma Kaneko; Kohjiro Ueki; Noriko Takahashi; Shinji Hashimoto; Masayuki Okamoto; Motoharu Awazawa; Yukiko Okazaki; Miho Ohsugi; Kazunori Inabe; Toshihiro Umehara; Masashi Yoshida; Masafumi Kakei; Tadahiro Kitamura; Ji Luo; Rohit N Kulkarni; C Ronald Kahn; Haruo Kasai; Lewis C Cantley; Takashi Kadowaki
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.
Cell metabolism 2010;12(6):619-32.
2010: Katsumi Nakata; Jina Choo; Michael J S Hopson; Hirotsugu Ueshima; J David Curb; Chol Shin; Rhobert W Evans; Takashi Kadowaki; Teruo Otake; Aya Kadota; Syaka Kadowaki; Katsuyuki Miura; Aiman El-Saed; Daniel Edmundowicz; Kim Sutton-Tyrrell; Lewis H Kuller; Akira Sekikawa
Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men.
Metabolism: clinical and experimental 2010;59(12):1742-51.
2010: Iseki Takamoto; Takashi Kadowaki
[New diagnostic criteria of diabetes mellitus in Japan, 2010].
Nihon rinsho. Japanese journal of clinical medicine 2010;68 Suppl 9():26-31.
2010: Yusuke Hada; Toshimasa Yamauchi; Takashi Kadowaki
[Incretin related drugs].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(10):1900-5.
2010: Longjian Liu; Tomonori Okamura; Takashi Kadowaki; Yoshitaka Murakami; Atsushi Hozawa; Yoshikuni Kita; Naoyuki Takashima; Nagako Okuda; Akira Okayama; Hirotsugu Ueshima
Bundle branch block and other cardiovascular disease risk factors: US-Japan comparison.
International journal of cardiology 2010;143(3):432-40.
2010: Naoyuki Takashima; K Miura; Atsushi Hozawa; Tomonori Okamura; Takehito Hayakawa; Nagako Okuda; Takashi Kadowaki; Yoshitaka Murakami; Yoshikuni Kita; Yasuyuki Nakamura; Akira Okayama; Hirotsugu Ueshima
Cigarette smoking in middle age and a long-term risk of impaired activities of daily living: NIPPON DATA80.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2010;12(9):944-9.
2010: Kensuke Otani; Joji Kitayama; Takao Kamei; Daisuke Soma; Hideyo Miyato; Toshimasa Yamauchi; Takashi Kadowaki; Hirokazu Nagawa
Adiponectin receptors are downregulated in human gastric cancer.
Journal of gastroenterology 2010;45(9):918-27.
2010: Zhao Guo; K Miura; Tanvir Chowdhury Turin; Atsushi Hozawa; Nagako Okuda; Tomonori Okamura; Shigeyuki Saitoh; Kiyomi Sakata; Hideaki Nakagawa; Akira Okayama; Katsushi Yoshita; Takashi Kadowaki; Sohel R Choudhury; Yasuyuki Nakamura; Beatriz L Rodriguez; David J Curb; Paul Elliott; Jeremiah Stamler; Hirotsugu Ueshima
Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic syndrome in Japanese: the INTERLIPID study.
Journal of atherosclerosis and thrombosis 2010;17(8):777-84.
2010: Ryoko W Azuma; Takashi Kadowaki; Aiman El-Saed; Hirotsugu Ueshima; Kim Sutton-Tyrrell; Yasuyuki Nakamura; Daniel Edmundowicz; Yoshiki Ueno; Rhobert W Evans; Aya Kadota; Lewis H Kuller; Kiyoshi Murata; Tomoko Takamiya; Sayaka Kadowaki; J David Curb; Akira Sekikawa
Associations of D-dimer and von Willebrand factor with atherosclerosis in Japanese and white men.
Acta cardiologica 2010;65(4):449-56.
2010: Akira Sekikawa; Takashi Kadowaki; J David Curb; Rhobert W Evans; Hiroshi Maegawa; Robert D Abbott; Kim Sutton-Tyrrell; Tomonori Okamura; Chol Shin; Daniel Edmundowicz; Aya Kadota; Jina Choo; Aiman El-Saed; Hirotsugu Ueshima; Lewis H Kuller
Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010;30(7):541-8.
2010: Jun Kurokawa; Satoko Arai; Katsuhiko Nakashima; Hiromichi Nagano; Akemi Nishijima; Keishi Miyata; Rui Ose; Mayumi Mori; Naoto Kubota; Takashi Kadowaki; Yuichi Oike; Hisashi Koga; Maria Febbraio; Toshihiko Iwanaga; Toru Miyazaki
Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.
Cell metabolism 2010;11(6):479-92.
2010: Yumiko Oishi; Ichiro Manabe; Yasushi Imai; Kazuo Hara; Momoko Horikoshi; Katsuhito Fujiu; Toshihiro Tanaka; Tadanori Aizawa; Takashi Kadowaki; Ryozo Nagai
Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(6):1780-8.
2010: Yukiko Okazaki; Kohjiro Ueki; Takashi Kadowaki
[Japan Diabetes Outcome Intervention Trial 3 (Japan Diabetes Optimal Integrated Treatment Study for 3 major risk factors of cardiovascular diseases: J-DOIT3)].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(5):861-4.
2010: Takashi Kadowaki
[Diabetic treatment strategies to control the onset and development of diabetic macrovascular disease].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(5):788-95.
2010: Masato Iwabu; Toshimasa Yamauchi; Miki Okada-Iwabu; Koji Sato; Tatsuro Nakagawa; Masaaki Funata; Mamiko Yamaguchi; Shigeyuki Namiki; Ryo Nakayama; Mitsuhisa Tabata; Hitomi Ogata; Naoto Kubota; Iseki Takamoto; Yukiko K Hayashi; Naoko Yamauchi; Hironori Waki; Masashi Fukayama; Ichizo Nishino; Kumpei Tokuyama; Kohjiro Ueki; Yuichi Oike; Satoshi Ishii; Kenzo Hirose; Takao Shimizu; Kazushige Touhara; Takashi Kadowaki
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
Nature 2010;464(7293):1313-9.
2010: Kensuke Otani; Joji Kitayama; Koji Yasuda; Yasunori Nio; Masato Iwabu; Shinichi Okudaira; Junken Aoki; Toshimasa Yamauchi; Takashi Kadowaki; Hirokazu Nagawa
Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice.
Cancer letters 2010;288(2):177-82.
2010: Atsushi Hozawa; Tomonori Okamura; Taichiro Tanaka; K Miura; Yuriko Kikuchi; Takashi Kadowaki; Katsushi Yoshita; Toru Takebayashi; Junko Tamaki; Junko Minai; Takayo Tada; Nagako Chiba; Akira Okayama; Hirotsugu Ueshima
Relation of Gamma-glutamyltransferase and alcohol drinking with incident diabetes: the HIPOP-OHP study.
Journal of atherosclerosis and thrombosis 2010;17(2):195-202.
2010: Hironori Waki; Toshimasa Yamauchi; Takashi Kadowaki
[PPARgamma antagonist as a potential drug for the treatment of obesity and diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(2):350-5.
2010: Hironori Waki; Toshimasa Yamauchi; Takashi Kadowaki
[Regulation of differentiation and hypertrophy of adipocytes and adipokine network by PPARgamma].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(2):210-6.
2010: Hironori Waki; Toshimasa Yamauchi; Takashi Kadowaki
[Recent advances in PPARgamma research].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(2):181-8.
2010: Unai Tamura; Taichiro Tanaka; Tomonori Okamura; Takashi Kadowaki; Hiroshi Yamato; Hideo Tanaka; Masakazu Nakamura; Akira Okayama; Hirotsugu Ueshima; Zentaro Yamagata
Changes in Weight, cardiovascular risk factors and estimated risk of coronary heart disease following smoking cessation in Japanese male workers: HIPOP-OHP study.
Journal of atherosclerosis and thrombosis 2010;17(1):12-20.
2010: Masaki Igarashi; Jun-ichi Osuga; Masashi Isshiki; Motohiro Sekiya; Hiroaki Okazaki; Satoru Takase; Mikio Takanashi; Keisuke Ohta; Masayoshi Kumagai; Makiko Nishi; Toshiro Fujita; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi
Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.
Journal of lipid research 2010;51(2):274-85.
2010: You Zhou; Norihiro Koizumi; Naoto Kubota; Takaharu Asano; Kazuhito Yuhashi; Takashi Mochizuki; Takashi Kadowaki; Ichiro Sakuma; Hongen Liao
Fast and accurate ultrasonography for visceral fat measurement.
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 2010;13(Pt 2):50-8.
2010: Naoyuki Takashima; K Miura; Atsushi Hozawa; Aya Kadota; Tomonori Okamura; Yasuyuki Nakamura; Takehito Hayakawa; Nagako Okuda; Akira Fujiyoshi; Shin-Ya Nagasawa; Takashi Kadowaki; Yoshitaka Murakami; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
Population attributable fraction of smoking and metabolic syndrome on cardiovascular disease mortality in Japan: a 15-year follow up of NIPPON DATA90.
BMC public health 2010;10():306.
2010: Koji Okamoto; Naoko Iwasaki; Chisa Nishimura; Kent Doi; Eisei Noiri; Shinko Nakamura; Miho Takizawa; Makiko Ogata; Risa Fujimaki; Niels Grarup; Charlotta Pisinger; Knut Borch-Johnsen; Torsten Lauritzen; Annelli Sandbaek; Torben Hansen; Kazuki Yasuda; Haruhiko Osawa; Kishio Nanjo; Takashi Kadowaki; Masato Kasuga; Oluf Pedersen; Toshiro Fujita; Naoyuki Kamatani; Yasuhiko Iwamoto; Katsushi Tokunaga
Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.
American journal of human genetics 2010;86(1):54-64.
2010: Yukiko Okazaki; Kazuhiro Eto; Tokuyuki Yamashita; Masayuki Okamoto; Mitsuru Ohsugi; Mitsuhiko Noda; Yasuo Terauchi; Kohjiro Ueki; Takashi Kadowaki
Decreased insulin secretion and accumulation of triglyceride in beta cells overexpressing a dominant-negative form of AMP-activated protein kinase.
Endocrine journal 2010;57(2):141-52.
2010: Takayuki Ohno; Osamu Kinoshita; Hideo Fujita; Satoshi Kato; Akira Hirose; Takashi Sigeeda; Kazuyoshi Otomo; Jiro Ando; Takashi Kadowaki; Makoto Araie; Ryozo Nagai; Shinichi Takamoto
Detecting occult coronary artery disease followed by early coronary artery bypass surgery in patients with diabetic retinopathy: report from a diabetic retinocoronary clinic.
The Journal of thoracic and cardiovascular surgery 2010;139(1):92-7.
2009: Yasuyuki Nakamura; Hirotsugu Ueshima; Aya Kadota; Atsushi Hozawa; Tomonori Okamura; Sayaka Kadowaki; Takashi Kadowaki; Takehito Hayakawa; Yoshikuni Kita; Robert D Abbott; Akira Okayama
Alcohol intake and 19-year mortality in diabetic men: NIPPON DATA80.
Alcohol (Fayetteville, N.Y.) 2009;43(8):635-41.
2009: Kazuo Hara; Takashi Kadowaki
How controlling of hypertension might matter.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(12):2208-9.
2009: Hisaka Kurita; Wataru Yoshioka; Noriko Nishimura; Naoto Kubota; Takashi Kadowaki; Chiharu Tohyama
Aryl hydrocarbon receptor-mediated effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on glucose-stimulated insulin secretion in mice.
Journal of applied toxicology : JAT 2009;29(8):689-94.
2009: Takeharu Asano; Kiyotaka Watanabe; Naoto Kubota; Toshiaki Gunji; Masao Omata; Takashi Kadowaki; Shin Ohnishi
Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis.
Journal of gastroenterology and hepatology 2009;24(10):1669-76.
2009: Motohiro Sekiya; Naoya Yahagi; Yoshiaki Tamura; Hiroaki Okazaki; Masaki Igarashi; Keisuke Ohta; Mikio Takanashi; Masayoshi Kumagai; Satoru Takase; Makiko Nishi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Ken Ohashi; Yoko Iizuka; Hiroaki Yagyu; Takanari Gotoda; Ryozo Nagai; Hitoshi Shimano; Nobuhiro Yamada; Takashi Kadowaki; Shun Ishibashi; Jun-ichi Osuga
Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.
Biochemical and biophysical research communications 2009;387(3):511-5.
2009: Tomonori Okamura; Akira Sekikawa; Takashi Kadowaki; Aiman El-Saed; Robert D Abbott; J David Curb; Daniel Edmundowicz; Yasuyuki Nakamura; Kiyoshi Murata; Atsunori Kashiwagi; Kim Sutton-Tyrrell; Rhobert W Evans; Joseph Zmuda; Hiroshi Maegawa; Atsushi Hozawa; Ken-Ichi Mitsunami; Yoshihiko Nishio; Iva Miljkovic-Gacic; Minoru Horie; Naomi Miyamatsu; Yoshitaka Murakami; Lewis H Kuller; Hirotsugu Ueshima
Cholesteryl ester transfer protein, coronary calcium, and intima-media thickness of the carotid artery in middle-age Japanese men.
The American journal of cardiology 2009;104(6):818-22.
2009: Motohiro Sekiya; Jun-ichi Osuga; Shuichi Nagashima; Taichi Ohshiro; Masaki Igarashi; Hiroaki Okazaki; Manabu Takahashi; Fumiko Tazoe; Taeko Wada; Keisuke Ohta; Mikio Takanashi; Masayoshi Kumagai; Makiko Nishi; Satoru Takase; Naoya Yahagi; Hiroaki Yagyu; Ken Ohashi; Ryozo Nagai; Takashi Kadowaki; Yusuke Furukawa; Shun Ishibashi
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
Cell metabolism 2009;10(3):219-28.
2009: Kaoru Nishide; Takashi Nagase; Miho Oba; Makoto Oe; Yumiko Ohashi; Shinji Iizaka; Gojiro Nakagami; Takashi Kadowaki; Hiromi Sanada
Ultrasonographic and thermographic screening for latent inflammation in diabetic foot callus.
Diabetes research and clinical practice 2009;85(3):304-9.
2009: Shinji Tamaki; Yasuyuki Nakamura; Yasuharu Tabara; Tomonori Okamura; Hideyuki Kanda; Yoshikuni Kita; Takashi Kadowaki; Yasuyuki Tsujita; Tanvir Chowdhury Turin; Minoru Horie; Tetsuro Miki; Hirotsugu Ueshima
Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study).
International journal of cardiology 2009;136(3):354-5.
2009: Satoshi Nishimura; Ichiro Manabe; Mika Nagasaki; Koji Eto; Hiroshi Yamashita; Miho Ohsugi; Makoto Otsu; Kazuo Hara; Kohjiro Ueki; Seiryo Sugiura; Kotaro Yoshimura; Takashi Kadowaki; Ryozo Nagai
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.
Nature medicine 2009;15(8):914-20.
2009: Koichiro Azuma; Takashi Kadowaki; Cemal Cetinel; Aya Kadota; Aiman El-Saed; Sayaka Kadowaki; Daniel Edmundowicz; Yoshihiko Nishio; Kim Sutton-Tyrrell; Tomonori Okamura; Rhobert W Evans; Tomoko Takamiya; Hirotsugu Ueshima; J David Curb; Robert D Abbott; Lewis H Kuller; David E Kelley; Akira Sekikawa
Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States.
Metabolism: clinical and experimental 2009;58(8):1200-7.
2009: Wataru Fukuo; Kazuhiro Yoshiuchi; Ken Ohashi; Hitomi Togashi; Rie Sekine; H Kikuchi; Noriyuki Sakamoto; Shuji Inada; Fumiyo Sato; Takashi Kadowaki; Akira Akabayashi
Development of a hand-held personal digital assistant-based food diary with food photographs for Japanese subjects.
Journal of the American Dietetic Association 2009;109(7):1232-6.
2009: Kenneth R Motoyama; J David Curb; Takashi Kadowaki; Aiman El-Saed; Robert D Abbott; Tomonori Okamura; Rhobert W Evans; Yasuyuki Nakamura; Kim Sutton-Tyrrell; Beatriz L Rodriquez; Aya Kadota; Daniel Edmundowicz; Bradley J Willcox; Jina Choo; Nakata Katsumi; Teruo Otake; Sayaka Kadowaki; Lewis H Kuller; Hirotusgu Ueshima; Akira Sekikawa
Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men.
The American journal of clinical nutrition 2009;90(1):49-55.
2009: Yasuyuki Nakamura; Akira Sekikawa; Takashi Kadowaki; Aya Kadota; Sayaka Kadowaki; Hiroshi Maegawa; Yoshikuni Kita; Rhobert W Evans; Daniel Edmundowicz; J David Curb; Hirotsugu Ueshima
Visceral and subcutaneous adiposity and adiponectin in middle-aged Japanese men: the ERA JUMP study.
Obesity (Silver Spring, Md.) 2009;17(6):1269-73.
2009: Masumi Hara; Yoshihiko Izumida; Nobuhiro Sato; Ken Ohashi; Jun-ichi Osuga; Kazuyuki Tobe; Kazuhisa Tsukamoto; Takashi Kadowaki
Successful desensitization by glargine administration in a patient with insulin allergy: a case report.
Diabetes research and clinical practice 2009;84(3):e48-9.
2009: Yasuyuki Nakamura; Hirotsugu Ueshima; Tomonori Okamura; Takashi Kadowaki; Takehito Hayakawa; Yoshikuni Kita; Robert D Abbott; Akira Okayama
A Japanese diet and 19-year mortality: national integrated project for prospective observation of non-communicable diseases and its trends in the aged, 1980.
The British journal of nutrition 2009;101(11):1696-705.
2009: Motoharu Awazawa; Kohjiro Ueki; Kazunori Inabe; Toshimasa Yamauchi; Kazuma Kaneko; Yukiko Okazaki; Nabeel Bardeesy; Shin Ohnishi; Ryozo Nagai; Takashi Kadowaki
Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway.
Biochemical and biophysical research communications 2009;382(1):51-6.
2009: Kazutaka Aoki; Junji Matsui; Naoto Kubota; Hiromu Nakajima; Keiji Iwamoto; Iseki Takamoto; Youki Tsuji; Akira Ohno; Shuuichi Mori; Kumpei Tokuyama; Koji Murakami; Tomoichiro Asano; Shinichi Aizawa; Kazuyuki Tobe; Takashi Kadowaki; Yasuo Terauchi
Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice.
American journal of physiology. Endocrinology and metabolism 2009;296(4):E842-53.
2009: Aya Higashiyama; Atsushi Hozawa; Yoshitaka Murakami; Tomonori Okamura; Makoto Watanabe; Yasuyuki Nakamura; Takehito Hayakawa; Takashi Kadowaki; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
Prognostic value of q wave for cardiovascular death in a 19-year prospective study of the Japanese general population.
Journal of atherosclerosis and thrombosis 2009;16(1):40-50.
2009: Masako Togo; Yoshiaki Hashimoto; Naoyuki Iso-o; Makoto Kurano; Masumi Hara; Takashi Kadowaki; Kazuhiko Koike; Kazuhisa Tsukamoto
Identification of a novel mutation for phytosterolemia. Genetic analyses of 2 cases.
Clinica chimica acta; international journal of clinical chemistry 2009;401(1-2):165-9.
2009: Akinobu Nakamura; Yasuo Terauchi; Sumika Ohyama; Junko Kubota; Hiroko Shimazaki; Tadahiro Nambu; Iseki Takamoto; Naoto Kubota; Junichi Eiki; Narihito Yoshioka; Takashi Kadowaki; Takao Koike
Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass.
Endocrinology 2009;150(3):1147-54.
2009: Toshimasa Yamauchi; Takashi Kadowaki
[Anti-metabolic syndrome effects of candesartan].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(2):408-16.
2009: Taku Watanabe; Naoto Kubota; Miho Ohsugi; Tetsuya Kubota; Iseki Takamoto; Masato Iwabu; Motoharu Awazawa; Hisayuki Katsuyama; Chiaki Hasegawa; Kumpei Tokuyama; Masao Moroi; Kaoru Sugi; Toshimasa Yamauchi; Tetsuo Noda; Ryozo Nagai; Yasuo Terauchi; Kazuyuki Tobe; Kohjiro Ueki; Takashi Kadowaki
Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.
The Journal of biological chemistry 2009;284(3):1803-12.
2009: Takashi Kadowaki; Mitsuyoshi Namba; Ayuko Yamamura; Hideaki Sowa; Anne M Wolka; Robert G Brodows
Exenatide exhibits dose-dependent effects on glycemic control over 12 weeks in Japanese patients with suboptimally controlled type 2 diabetes.
Endocrine journal 2009;56(3):415-24.
2008: Toshimasa Yamauchi; Takashi Kadowaki
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases.
International journal of obesity (2005) 2008;32 Suppl 7():S13-8.
2008: Robert D Abbott; Hirotsugu Ueshima; Atsushi Hozawa; Tomonori Okamura; Takashi Kadowaki; Katsuyuki Miura; Nagako Okuda; Yasuyuki Nakamura; Akira Okayama; Yoshikuni Kita; Beatriz L Rodriguez; Katsuhiko Yano; J David Curb
Risk factor effects and total mortality in older Japanese men in Japan and Hawaii.
Annals of epidemiology 2008;18(12):913-8.
2008: Hiroaki Okazaki; Masaki Igarashi; Makiko Nishi; Motohiro Sekiya; Makiko Tajima; Satoru Takase; Mikio Takanashi; Keisuke Ohta; Yoshiaki Tamura; Sachiko Okazaki; Naoya Yahagi; Ken Ohashi; Michiyo Amemiya-Kudo; Yoshimi Nakagawa; Ryozo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
The Journal of biological chemistry 2008;283(48):33357-64.
2008: Iseki Takamoto; Yasuo Terauchi; Naoto Kubota; Miho Ohsugi; Keisuke Ueki; Takashi Kadowaki
Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance.
Diabetes, obesity & metabolism 2008;10 Suppl 4():147-56.
2008: Shoko Uchida-Kitajima; Toshimasa Yamauchi; Youko Takashina; Miki Okada-Iwabu; Masato Iwabu; Kohjiro Ueki; Takashi Kadowaki
5-Hydroxytryptamine 2A receptor signaling cascade modulates adiponectin and plasminogen activator inhibitor 1 expression in adipose tissue.
FEBS letters 2008;582(20):3037-44.
2008: Toshimasa Yamauchi; Takashi Kadowaki
[Glucose intolerance -- diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2008;66(9):1753-60.
2008: Akira Sekikawa; J David Curb; Hirotsugu Ueshima; Aiman El-Saed; Takashi Kadowaki; Robert D Abbott; Rhobert W Evans; Beatriz L Rodriguez; Tomonori Okamura; Kim Sutton-Tyrrell; Yasuyuki Nakamura; Kamal Masaki; Daniel Edmundowicz; Atsunori Kashiwagi; Bradley J Willcox; Tomoko Takamiya; Kenichi Mitsunami; Todd B Seto; Kiyoshi Murata; Roger L White; Lewis H Kuller
Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study.
Journal of the American College of Cardiology 2008;52(6):417-24.
2008: Aya Kadota; Tomonori Okamura; Atsushi Hozawa; Takashi Kadowaki; Yoshitaka Murakami; Takehito Hayakawa; Yoshikuni Kita; Akira Okayama; Yasuyuki Nakamura; Hirotsugu Ueshima
Relationships between family histories of stroke and of hypertension and stroke mortality: NIPPON DATA80, 1980-1999.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(8):1525-31.
2008: Yasuyuki Nakamura; Hirotsugu Ueshima; Nagako Okuda; Aya Higashiyama; Yoshikuni Kita; Takashi Kadowaki; Tomonori Okamura; Yoshitaka Murakami; Akira Okayama; Sohel Reza Choudhury; Beatriz L Rodriguez; J David Curb; Jeremiah Stamler
Relation of dietary and other lifestyle traits to difference in serum adiponectin concentration of Japanese in Japan and Hawaii: the INTERLIPID Study.
The American journal of clinical nutrition 2008;88(2):424-30.
2008: K Takasawa; Naoto Kubota; Yasuo Terauchi; Takashi Kadowaki
Impact of increased PPARgamma activity in adipocytes in vivo on adiposity, insulin sensitivity and the effects of rosiglitazone treatment.
Endocrine journal 2008;55(4):767-76.
2008: Motohiro Sekiya; Jun-ichi Osuga; Naoya Yahagi; Hiroaki Okazaki; Yoshiaki Tamura; Masaki Igarashi; Satoru Takase; Kenji Harada; Sachiko Okazaki; Yoko Iizuka; Ken Ohashi; Hiroaki Yagyu; Mitsuyo Okazaki; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.
Journal of lipid research 2008;49(8):1829-38.
2008: Naoto Kubota; Tetsuya Kubota; Shinsuke Itoh; Hiroki Kumagai; Hideki Kozono; Iseki Takamoto; Tomoka Mineyama; Hitomi Ogata; Kumpei Tokuyama; Miho Ohsugi; Takayoshi Sasako; Masao Moroi; Kaoru Sugi; Shigeru Kakuta; Yoichiro Iwakura; Tetsuo Noda; Shin Ohnishi; Ryozo Nagai; Kazuyuki Tobe; Yasuo Terauchi; Kohjiro Ueki; Takashi Kadowaki
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.
Cell metabolism 2008;8(1):49-64.
2008: Wataru Yano; Naoto Kubota; Shinsuke Itoh; Tetsuya Kubota; Motoharu Awazawa; Masao Moroi; Kaoru Sugi; Iseki Takamoto; Hitomi Ogata; Kumpei Tokuyama; Tetsuo Noda; Yasuo Terauchi; Kohjiro Ueki; Takashi Kadowaki
Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.
Endocrine journal 2008;55(3):515-22.
2008: Atsushi Hozawa; Tomonori Okamura; Izumi Oki; Yoshitaka Murakami; Takashi Kadowaki; Koshi Nakamura; Naomi Miyamatsu; Takehito Hayakawa; Yoshikuni Kita; Yosikazu Nakamura; Yasuyuki Nakamura; Robert D Abbott; Akira Okayama; Hirotsugu Ueshima
Relationship between BMI and all-cause mortality in Japan: NIPPON DATA80.
Obesity (Silver Spring, Md.) 2008;16(7):1714-7.
2008: Yumiko Oishi; Ichiro Manabe; Kazuyuki Tobe; Miho Ohsugi; Tetsuya Kubota; Katsuhito Fujiu; Koji Maemura; Naoto Kubota; Takashi Kadowaki; Ryozo Nagai
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
Nature medicine 2008;14(6):656-66.
2008: Guoqin Wang; Masafumi Watanabe; Yasushi Imai; Kazuo Hara; Ichiro Manabe; Koji Maemura; Momoko Horikoshi; Kohro Takahide; Eisuke Amiya; Takao Sugiyama; T Fujita; Takashi Kadowaki; Tsutomu Yamazaki; Ryozo Nagai
Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population.
International heart journal 2008;49(3):313-27.
2008: M Okamoto; Mica Ohara-Imaizumi; Naoto Kubota; S Hashimoto; Kazuhiro Eto; T Kanno; Tetsuya Kubota; M Wakui; Ryozo Nagai; Mitsuhiko Noda; S Nagamatsu; Takashi Kadowaki
Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration.
Diabetologia 2008;51(5):827-35.
2008: Takako Yamamoto; Yasuyuki Nakamura; Atsushi Hozawa; Tomonori Okamura; Takashi Kadowaki; Takehito Hayakawa; Yoshitaka Murakami; Yoshikuni Kita; Akira Okayama; Robert D Abbott; Hirotsugu Ueshima
Low-risk profile for cardiovascular disease and mortality in Japanese.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(4):545-50.
2008: Yasuaki Hayashino; Shunichi Fukuhara; Tomonori Okamura; Hiroshi Yamato; Hideo Tanaka; Taichiro Tanaka; Takashi Kadowaki; Hirotsugu Ueshima
A prospective study of passive smoking and risk of diabetes in a cohort of workers: the High-Risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study.
Diabetes care 2008;31(4):732-4.
2008: S Kadowaki; T Okamura; A Hozawa; Takashi Kadowaki; A Kadota; Yoshitaka Murakami; K Nakamura; S Saitoh; Yasuyuki Nakamura; T Hayakawa; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
Relationship of elevated casual blood glucose level with coronary heart disease, cardiovascular disease and all-cause mortality in a representative sample of the Japanese population. NIPPON DATA80.
Diabetologia 2008;51(4):575-82.
2008: Jina Choo; Hirotsugu Ueshima; Yangsoo Jang; Kim Sutton-Tyrrell; Aiman El-Saed; Takashi Kadowaki; Tomoko Takamiya; Tomonori Okamura; Yoshiki Ueno; Yasuyuki Nakamura; Akira Sekikawa; J David Curb; Lewis H Kuller; Chol Shin
Difference in carotid intima-media thickness between Korean and Japanese men.
Annals of epidemiology 2008;18(4):310-5.
2008: Tomonori Okamura; Takehito Hayakawa; Atsushi Hozawa; Takashi Kadowaki; Yoshitaka Murakami; Yoshikuni Kita; Robert D Abbott; Akira Okayama; Hirotsugu Ueshima
Lower levels of serum albumin and total cholesterol associated with decline in activities of daily living and excess mortality in a 12-year cohort study of elderly Japanese.
Journal of the American Geriatrics Society 2008;56(3):529-35.
2008: Satoshi Nishimura; Ichiro Manabe; Mika Nagasaki; Kinya Seo; Hiroshi Yamashita; Yumiko Hosoya; Miho Ohsugi; Kazuyuki Tobe; Takashi Kadowaki; Ryozo Nagai; Seiryo Sugiura
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue.
The Journal of clinical investigation 2008;118(2):710-21.
2008: Akira Sekikawa; Hirotsugu Ueshima; Kim Sutton-Tyrrell; Takashi Kadowaki; Aiman El-Saed; Tomonori Okamura; Tomoko Takamiya; Yoshiki Ueno; Rhobert W Evans; Yasuyuki Nakamura; Daniel Edmundowicz; Atsunori Kashiwagi; Hiroshi Maegawa; Lewis H Kuller
Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study.
Metabolism: clinical and experimental 2008;57(2):177-82.
2008: Aiman El-Saed; Akira Sekikawa; Daniel Edmundowicz; Rhobert W Evans; Kim Sutton-Tyrrell; Takashi Kadowaki; Jina Choo; Tomoko Takamiya; Lewis H Kuller
Coronary calcification is more predictive of carotid intimal medial thickness in black compared to white middle aged men.
Atherosclerosis 2008;196(2):913-8.
2008: Takashi Kadowaki; Toshimasa Yamauchi; Naoto Kubota
The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS.
FEBS letters 2008;582(1):74-80.
2008: Nobuko Seike; Mitsuhiko Noda; Takashi Kadowaki
Alcohol consumption and risk of type 2 diabetes mellitus in Japanese: a systematic review.
Asia Pacific journal of clinical nutrition 2008;17(4):545-51.
2008: Yuko Kamon; Tomonori Okamura; Taichiro Tanaka; Atsushi Hozawa; Zentaro Yamagata; Toru Takebayashi; Yukinori Kusaka; Sumio Urano; Hideaki Nakagawa; Takashi Kadowaki; Yuji Miyoshi; Hiroshi Yamato; Akira Okayama; Hirotsugu Ueshima
Marital status and cardiovascular risk factors among middle-aged Japanese male workers: the High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study.
Journal of occupational health 2008;50(4):348-56.
2008: Kazuaki Miyake; Yukio Horikawa; Kazuo Hara; Kazuki Yasuda; Haruhiko Osawa; Hiroto Furuta; Yushi Hirota; Kazuya Yamagata; Yoshinori Hinokio; Yoshitomo Oka; Naoko Iwasaki; Yasuhiko Iwamoto; Yuichiro Yamada; Yutaka Seino; Hiroshi Maegawa; Atsunori Kashiwagi; Ken Yamamoto; Katsushi Tokunaga; Jun Takeda; Hideichi Makino; Kishio Nanjo; Takashi Kadowaki; Masato Kasuga
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
Journal of human genetics 2008;53(2):174-80.
2007: Atsushi Hozawa; Tomonori Okamura; Yoshitaka Murakami; Takashi Kadowaki; Koshi Nakamura; Takehito Hayakawa; Yoshikuni Kita; Yasuyuki Nakamura; Robert D Abbott; Akira Okayama; Hirotsugu Ueshima
Joint impact of smoking and hypertension on cardiovascular disease and all-cause mortality in Japan: NIPPON DATA80, a 19-year follow-up.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(12):1169-75.
2007: Momoko Horikoshi; Kazuo Hara; Chikako Ito; Nobuhiro Shojima; Ryozo Nagai; Keisuke Ueki; philippe froguel; Takashi Kadowaki
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
Diabetologia 2007;50(12):2461-6.
2007: Robert D Abbott; Hirotsugu Ueshima; Beatriz L Rodriguez; Takashi Kadowaki; Kamal H Masaki; Bradley J Willcox; Akira Sekikawa; Lewis H Kuller; Daniel Edmundowicz; Chol Shin; Atsunori Kashiwagi; Yasuyuki Nakamura; Aiman El-Saed; Tomonori Okamura; Roger White; J David Curb
Coronary artery calcification in Japanese men in Japan and Hawaii.
American journal of epidemiology 2007;166(11):1280-7.
2007: Yoshinori Takeuchi; Naoya Yahagi; Yoshimi Nakagawa; Takashi Matsuzaka; Ritsuko Shimizu; Motohiro Sekiya; Yoko Iizuka; Ken Ohashi; Takanari Gotoda; Masayuki Yamamoto; Ryozo Nagai; Takashi Kadowaki; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression.
Biochemical and biophysical research communications 2007;363(2):329-35.
2007: Aiman El-Saed; Akira Sekikawa; Riad Wahid Zaky; Takashi Kadowaki; Tomoko Takamiya; Tomonori Okamura; Daniel Edmundowicz; Yoshikuni Kita; Lewis H Kuller; Hirotsugu Ueshima
Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men.
Journal of epidemiology / Japan Epidemiological Association 2007;17(6):179-85.
2007: Shinji Kume; Takashi Uzu; Shin-ichi Araki; Toshiro Sugimoto; Keiji Isshiki; Masami Chin-Kanasaki; Masayoshi Sakaguchi; Naoto Kubota; Yasuo Terauchi; Takashi Kadowaki; Masakazu Haneda; Atsunori Kashiwagi; Daisuke Koya
Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet.
Journal of the American Society of Nephrology : JASN 2007;18(10):2715-23.
2007: Atsushi Hozawa; Tomonori Okamura; Takashi Kadowaki; Yoshitaka Murakami; Koshi Nakamura; Takehito Hayakawa; Yoshikuni Kita; Yasuyuki Nakamura; Akira Okayama
Is weak association between cigarette smoking and cardiovascular disease mortality observed in Japan explained by low total cholesterol? NIPPON DATA80.
International journal of epidemiology 2007;36(5):1060-7.
2007: Atsushi Hozawa; Tomonori Okamura; Takashi Kadowaki; Yoshitaka Murakami; Koshi Nakamura; Takehito Hayakawa; Yoshikuni Kita; Yasuyuki Nakamura; Akira Okayama; Hirotsugu Ueshima
gamma-Glutamyltransferase predicts cardiovascular death among Japanese women.
Atherosclerosis 2007;194(2):498-504.
2007: Koshi Nakamura; Tomonori Okamura; Takehito Hayakawa; Atsushi Hozawa; Takashi Kadowaki; Yoshitaka Murakami; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
The proportion of individuals with alcohol-induced hypertension among total hypertensives in a general Japanese population: NIPPON DATA90.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(8):663-8.
2007: Yasuyuki Nakamura; Yoshiki Ueno; Shinji Tamaki; Takashi Kadowaki; Tomonori Okamura; Yoshikuni Kita; Naomi Miyamatsu; Akira Sekikawa; Tomoko Takamiya; Aiman El-Saed; Kim Sutton-Tyrrell; Hirotsugu Ueshima
Fish consumption and early atherosclerosis in middle-aged men.
Metabolism: clinical and experimental 2007;56(8):1060-4.
2007: Hiroyuki Ebinuma; Takashi Miida; Toshimasa Yamauchi; Yusuke Hada; Kazuo Hara; Naoto Kubota; Takashi Kadowaki
Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid.
Clinical chemistry 2007;53(8):1541-4.
2007: Hiroaki Kawanishi; Tsuyoshi Takahashi; Masaaki Ito; Y Matsui; Jun Watanabe; N Ito; Toshiyuki Kamoto; Takashi Kadowaki; Gozoh Tsujimoto; I Imoto; Johji Inazawa; Hiroyuki Nishiyama; Osamu Ogawa
Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation.
British journal of cancer 2007;97(2):260-6.
2007: Naoto Kubota; Wataru Yano; Tetsuya Kubota; Toshimasa Yamauchi; Shinsuke Itoh; Hiroki Kumagai; Hideki Kozono; Iseki Takamoto; Shiki Okamoto; Tetsuya Shiuchi; Ryo Suzuki; Hidemi Satoh; Atsushi Tsuchida; Masao Moroi; Kaoru Sugi; Tetsuo Noda; Hiroyuki Ebinuma; Yoichi Ueta; Tatsuya Kondo; Eiichi Araki; Osamu Ezaki; Ryozo Nagai; Kazuyuki Tobe; Yasuo Terauchi; Kohjiro Ueki; Yasuhiko Minokoshi; Takashi Kadowaki
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
Cell metabolism 2007;6(1):55-68.
2007: S Matsunaga-Irie; Hirotsugu Ueshima; Wahid R Zaky; Takashi Kadowaki; Rhobert W Evans; Tomonori Okamura; Tomoko Takamiya; Yoshikuni Kita; Lewis H Kuller; Akira Sekikawa
Serum ghrelin levels are higher in Caucasian men than Japanese men aged 40-49 years.
Diabetes, obesity & metabolism 2007;9(4):591-3.
2007: Makoto Ishikawa; Joji Kitayama; Toshimasa Yamauchi; Takashi Kadowaki; Toshiyuki Maki; Hideyo Miyato; Hiroharu Yamashita; Hirokazu Nagawa
Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.
Cancer science 2007;98(7):1120-7.
2007: Motohiro Sekiya; Naoya Yahagi; Takashi Matsuzaka; Yoshinori Takeuchi; Yoshimi Nakagawa; Haruka Takahashi; Hiroaki Okazaki; Yoko Iizuka; Ken Ohashi; Takanari Gotoda; Shun Ishibashi; Ryozo Nagai; Tsutomu Yamazaki; Takashi Kadowaki; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
SREBP-1-independent regulation of lipogenic gene expression in adipocytes.
Journal of lipid research 2007;48(7):1581-91.
2007: Tomonori Okamura; Koshi Nakamura; Hideyuki Kanda; Takehito Hayakawa; Atsushi Hozawa; Yoshitaka Murakami; Takashi Kadowaki; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
Effect of combined cardiovascular risk factors on individual and population medical expenditures: a 10-year cohort study of national health insurance in a Japanese population.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(6):807-13.
2007: Satoshi Nishimura; Ichiro Manabe; Mika Nagasaki; Yumiko Hosoya; Hiroshi Yamashita; Hideo Fujita; Miho Ohsugi; Kazuyuki Tobe; Takashi Kadowaki; Ryozo Nagai; Seiryo Sugiura
Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.
Diabetes 2007;56(6):1517-26.
2007: Yusuke Hada; Toshimasa Yamauchi; Hironori Waki; Atsushi Tsuchida; Kazuo Hara; Hirokazu Yago; Osamu Miyazaki; Hiroyuki Ebinuma; Takashi Kadowaki
Selective purification and characterization of adiponectin multimer species from human plasma.
Biochemical and biophysical research communications 2007;356(2):487-93.
2007: Yasuyuki Nakamura; Tanvir C Turin; Yoshikuni Kita; Shinji Tamaki; Yasuyuki Tsujita; Takashi Kadowaki; Yoshitaka Murakami; Tomonori Okamura; Hirotsugu Ueshima
Associations of obesity measures with metabolic risk factors in a community-based population in Japan.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(5):776-81.
2007: Aya Higashiyama; Yoshitaka Murakami; Atsushi Hozawa; Tomonori Okamura; Takehito Hayakawa; Takashi Kadowaki; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
Does self-reported history of hypertension predict cardiovascular death? Comparison with blood pressure measurement in a 19-year prospective study.
Journal of hypertension 2007;25(5):959-64.
2007: Tamae Shimazaki; Takashi Kadowaki; Yoshiharu Ohyama; Kazuhiko Ohe; Kiyoshi Kubota
Hemoglobin A1c (HbA1c) predicts future drug treatment for diabetes mellitus: a follow-up study using routine clinical data in a Japanese university hospital.
Translational research : the journal of laboratory and clinical medicine 2007;149(4):196-204.
2007: Momoko Horikoshi; Kazuo Hara; Chikako Ito; Ryozo Nagai; philippe froguel; Takashi Kadowaki
A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
Diabetologia 2007;50(4):747-51.
2007: Akira Sekikawa; Hirotsugu Ueshima; Takashi Kadowaki; Aiman El-Saed; Tomonori Okamura; Tomoko Takamiya; Atsunori Kashiwagi; Daniel Edmundowicz; Kiyoshi Murata; Kim Sutton-Tyrrell; Hiroshi Maegawa; Rhobert W Evans; Yoshikuni Kita; Lewis H Kuller
Less subclinical atherosclerosis in Japanese men in Japan than in White men in the United States in the post-World War II birth cohort.
American journal of epidemiology 2007;165(6):617-24.
2007: Yoshitaka Murakami; Hirotsugu Ueshima; Tomonori Okamura; Takashi Kadowaki; Atsushi Hozawa; Yoshikuni Kita; Takehito Hayakawa; Akira Okayama
Life expectancy among Japanese of different smoking status in Japan: NIPPON DATA80.
Journal of epidemiology / Japan Epidemiological Association 2007;17(2):31-7.
2007: Kazuo Hara; Toshimasa Yamauchi; Yasushi Imai; Ichiro Manabe; Ryozo Nagai; Takashi Kadowaki
Reduced adiponectin level is associated with severity of coronary artery disease.
International heart journal 2007;48(2):149-53.
2007: Toshimasa Yamauchi; Yasunori Nio; Toshiyuki Maki; Masaki Kobayashi; Takeshi Takazawa; Masato Iwabu; Miki Okada-Iwabu; Sachiko Kawamoto; Naoto Kubota; Tetsuya Kubota; Yusuke Ito; Junji Kamon; Atsushi Tsuchida; Katsuyoshi Kumagai; Hideki Kozono; Yusuke Hada; Hitomi Ogata; Kumpei Tokuyama; Masaki Tsunoda; Tomohiro Ide; Kouji Murakami; Motoharu Awazawa; Iseki Takamoto; philippe froguel; Kazuo Hara; Kazuyuki Tobe; Ryozo Nagai; Kohjiro Ueki; Takashi Kadowaki
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Nature medicine 2007;13(3):332-9.
2007: Yasuyuki Tsujita; Yasuyuki Nakamura; Qishan Zhang; Shinji Tamaki; Akihiko Nozaki; Kenji Amamoto; Takashi Kadowaki; Yoshikuni Kita; Tomonori Okamura; Minoru Horie; Hirotsugu Ueshima
The association between high-density lipoprotein cholesterol level and cholesteryl ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample.
Atherosclerosis 2007;191(1):199-205.
2007: Takashi Kadowaki; Toshimasa Yamauchi; Naoto Kubota; Kazuo Hara; Keisuke Ueki
Adiponectin and adiponectin receptors in obesity-linked insulin resistance.
Novartis Foundation symposium 2007;286():164-76; discussion 176-82, 200-3.
2007: Naohiro Kawamura; Fumitaka Kugimiya; Yasushi Oshima; Shinsuke Ohba; Toshiyuki Ikeda; Taku Saito; Yusuke Shinoda; Yosuke Kawasaki; Naoshi Ogata; Kazuto Hoshi; Toru Akiyama; William S Chen; Nissim Hay; Kazuyuki Tobe; Takashi Kadowaki; Yoshiaki Azuma; Sakae Tanaka; Kozo Nakamura; Ung-il Chung; Hiroshi Kawaguchi
Akt1 in osteoblasts and osteoclasts controls bone remodeling.
PloS one 2007;2(10):e1058.
2007: Koshi Nakamura; Tomonori Okamura; Takehito Hayakawa; Atsushi Hozawa; Takashi Kadowaki; Yoshitaka Murakami; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
The proportion of individuals with obesity-induced hypertension among total hypertensives in a general Japanese population: NIPPON DATA80, 90.
European journal of epidemiology 2007;22(10):691-8.
2007: Yasuo Terauchi; Iseki Takamoto; Naoto Kubota; Junji Matsui; Ryo Suzuki; Kajuro Komeda; Akemi Hara; Yukiyasu Toyoda; Ichitomo Miwa; Shinichi Aizawa; Shuichi Tsutsumi; Yoshiharu Tsubamoto; Shinji Hashimoto; Kazuhiro Eto; Akinobu Nakamura; Mitsuhiko Noda; Kazuyuki Tobe; Hiroyuki Aburatani; Ryozo Nagai; Takashi Kadowaki
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
The Journal of clinical investigation 2007;117(1):246-57.
2007: Atsushi Hozawa; Yoshitaka Murakami; Tomonori Okamura; Takashi Kadowaki; Koshi Nakamura; Takehito Hayakawa; Yoshikuni Kita; Yasuyuki Nakamura; Akira Okayama; Hirotsugu Ueshima
Relation of adult height with stroke mortality in Japan: NIPPON DATA80.
Stroke; a journal of cerebral circulation 2007;38(1):22-6.
2007: Tomonori Okamura; Hideo Tanaka; Naomi Miyamatsu; Takehito Hayakawa; Takashi Kadowaki; Yoshikuni Kita; Yasuyuki Nakamura; Akira Okayama; Hirotsugu Ueshima
The relationship between serum total cholesterol and all-cause or cause-specific mortality in a 17.3-year study of a Japanese cohort.
Atherosclerosis 2007;190(1):216-23.
2006: Kohjiro Ueki; Takashi Kadowaki
[Signaling molecules as the therapeutic targets for the metabolic syndrome].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():679-84.
2006: Yusuke Hada; Takashi Kadowaki; Toshimasa Yamauchi
[AMPK].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():282-6.
2006: Taku Watanabe; Kazuyuki Tobe; Takashi Kadowaki; Nozomu Kamei
[Insulin resistance in central nerve system].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():158-62.
2006: Toshimasa Yamauchi; Takashi Kadowaki
[The roles of adipokines in the regulation of insulin sensitivity].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():132-8.
2006: Takashi Kadowaki; Akira Sekikawa; Tomonori Okamura; Tomoko Takamiya; Atsunori Kashiwagi; Wahid R Zaky; Hiroshi Maegawa; Aiman El-Saed; Yasuyuki Nakamura; Rhobert W Evans; Daniel Edmundowicz; Yoshikuni Kita; Lewis H Kuller; Hirotsugu Ueshima
Higher levels of adiponectin in American than in Japanese men despite obesity.
Metabolism: clinical and experimental 2006;55(12):1561-3.
2006: Shinji Tamaki; Yasuyuki Nakamura; Yasuharu Tabara; Tomonori Okamura; Yoshikuni Kita; Takashi Kadowaki; Yasuyuki Tsujita; Minoru Horie; Tetsuro Miki; Hirotsugu Ueshima
Relationship between metabolic syndrome and Trp64arg polymorphism of the beta-adrenergic receptor gene in a general sample: the Shigaraki study.
Hypertension research : official journal of the Japanese Society of Hypertension 2006;29(11):891-6.
2006: Kimimasa Muranaka; Yasuo Yanagi; Yasuhiro Tamaki; Tomohiko Usui; Naoto Kubota; Aya Iriyama; Yasuo Terauchi; Takashi Kadowaki; Makoto Araie
Effects of peroxisome proliferator-activated receptor gamma and its ligand on blood-retinal barrier in a streptozotocin-induced diabetic model.
Investigative ophthalmology & visual science 2006;47(10):4547-52.
2006: Hiroyuki Ebinuma; Osamu Miyazaki; Hirokazu Yago; Kazuo Hara; Toshimasa Yamauchi; Takashi Kadowaki
A novel ELISA system for selective measurement of human adiponectin multimers by using proteases.
Clinica chimica acta; international journal of clinical chemistry 2006;372(1-2):47-53.
2006: Nozomu Kamei; Kazuyuki Tobe; Ryo Suzuki; Miho Ohsugi; Taku Watanabe; Naoto Kubota; Norie Ohtsuka-Kowatari; Katsuyoshi Kumagai; Kentaro Sakamoto; Masatoshi Kobayashi; Toshimasa Yamauchi; Kohjiro Ueki; Yumiko Oishi; Satoshi Nishimura; Ichiro Manabe; Haruo Hashimoto; Yasuyuki Ohnishi; Hitomi Ogata; Kumpei Tokuyama; Masaki Tsunoda; Tomohiro Ide; Koji Murakami; Ryozo Nagai; Takashi Kadowaki
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.
The Journal of biological chemistry 2006;281(36):26602-14.
2006: Sachiyo Nomura; Atsushi Nakajima; S Ishimine; Nobuyuki Matsuhashi; Takashi Kadowaki; Michio Kaminishi
Differential expression of peroxisome proliferator-activated receptor in histologically different human gastric cancer tissues.
Journal of experimental & clinical cancer research : CR 2006;25(3):443-8.
2006: Takashi Kadowaki; Makoto Watanabe; Akira Okayama; Kayoko Hishida; Tomonori Okamura; Naomi Miyamatsu; Takehito Hayakawa; Yoshikuni Kita; Hirotsugu Ueshima
Continuation of smoking cessation and following weight change after intervention in a healthy population with high smoking prevalence.
Journal of occupational health 2006;48(5):402-6.
2006: Hiroaki Okazaki; Fumiko Tazoe; Sachiko Okazaki; Noriko Isoo; Kazuhisa Tsukamoto; Motohiro Sekiya; Naoya Yahagi; Yoko Iizuka; Ken Ohashi; Tetsuya Kitamine; Ryuichi Tozawa; Toshihiro Inaba; Hiroaki Yagyu; Mitsuyo Okazaki; Hitoshi Shimano; Norihito Shibata; Hiroyuki Arai; Ryo-Zo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
Journal of lipid research 2006;47(9):1950-8.
2006: Yusuke Shinoda; Masayuki Yamaguchi; Naoshi Ogata; Toru Akune; Naoto Kubota; Toshimasa Yamauchi; Yasuo Terauchi; Takashi Kadowaki; Yasuhiro Takeuchi; Seiji Fukumoto; Toshiyuki Ikeda; Kazuto Hoshi; Ung-il Chung; Kozo Nakamura; Hiroshi Kawaguchi
Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways.
Journal of cellular biochemistry 2006;99(1):196-208.
2006: Yasuyuki Nakamura; Takako Yamamoto; Tomonori Okamura; Takashi Kadowaki; Takehito Hayakawa; Yoshikuni Kita; Shigeyuki Saitoh; Akira Okayama; Hirotsugu Ueshima
Combined cardiovascular risk factors and outcome: NIPPON DATA80, 1980-1994.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(8):960-4.
2006: Koshi Nakamura; Tomonori Okamura; Takehito Hayakawa; Takashi Kadowaki; Yoshikuni Kita; Hirofumi Ohnishi; Shigeyuki Saitoh; Kiyomi Sakata; Akira Okayama; Hirotsugu Ueshima
Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan: NIPPON DATA90.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(8):954-9.
2006: Masumi Hara; Naoyuki Iso-o; Hiroaki Satoh; Hiroshi Noto; Masako Togo; Shun Ishibashi; Satoshi Kimura; Takashi Kadowaki; Yoshiaki Hashimoto; Kazuhisa Tsukamoto
Differential effects of apolipoprotein E isoforms on lipolysis of very low-density lipoprotein triglycerides.
Metabolism: clinical and experimental 2006;55(8):1129-34.
2006: Tomonori Okamura; Takashi Kadowaki; Akira Sekikawa; Kiyoshi Murata; Naomi Miyamatsu; Yasuyuki Nakamura; Aiman El-Saed; Atsunori Kashiwagi; Hiroshi Maegawa; Yoshihiko Nishio; Tomoko Takamiya; Hideyuki Kanda; Kenichi Mitsunami; Yoshikuni Kita; Daniel Edmundowicz; Shinji Tamaki; Yasuyuki Tsujita; Lewis H Kuller; Hirotsugu Ueshima
Alcohol consumption and coronary artery calcium in middle-aged Japanese men.
The American journal of cardiology 2006;98(2):141-4.
2006: Takashi Kadowaki; Toshimasa Yamauchi; Naoto Kubota; Kazuo Hara; Kohjiro Ueki; Kazuyuki Tobe
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
The Journal of clinical investigation 2006;116(7):1784-92.
2006: Yuri Takemura; Yutaka Osuga; Toshimasa Yamauchi; Masaki Kobayashi; Miyuki Harada; Tetsuya Hirata; Chieko Morimoto; Yasushi Hirota; Osamu Yoshino; Kaori Koga; Tetsu Yano; Takashi Kadowaki; Yuji Taketani
Expression of adiponectin receptors and its possible implication in the human endometrium.
Endocrinology 2006;147(7):3203-10.
2006: Takashi Kadowaki; Akira Sekikawa; Kiyoshi Murata; Hiroshi Maegawa; Tomoko Takamiya; Tomonori Okamura; Aiman El-Saed; Naomi Miyamatsu; Daniel Edmundowicz; Yoshikuni Kita; Kim Sutton-Tyrrell; Lewis H Kuller; Hirotsugu Ueshima
Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study.
International journal of obesity (2005) 2006;30(7):1163-5.
2006: Kazuo Hara; Momoko Horikoshi; Toshimasa Yamauchi; Hirokazu Yago; Osamu Miyazaki; Hiroyuki Ebinuma; Yasushi Imai; Ryozo Nagai; Takashi Kadowaki
Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.
Diabetes care 2006;29(6):1357-62.
2006: Koshi Nakamura; Tomonori Okamura; Takehito Hayakawa; Takashi Kadowaki; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
Electrocardiogram screening for left high R-wave predicts cardiovascular death in a Japanese community-based population: NIPPON DATA90.
Hypertension research : official journal of the Japanese Society of Hypertension 2006;29(5):353-60.
2006: Kazuo Hara; Momoko Horikoshi; Hiroshi Kitazato; Chikako Ito; Mitsuhiko Noda; Jun Ohashi; philippe froguel; Katsushi Tokunaga; Kazuyuki Tobe; Ryozo Nagai; Takashi Kadowaki
Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.
Diabetes 2006;55(5):1260-4.
2006: Kazuo Hara; Yumi Matsushita; Momoko Horikoshi; Nobuo Yoshiike; Tetsuji Yokoyama; Heizo Tanaka; Takashi Kadowaki
A proposal for the cutoff point of waist circumference for the diagnosis of metabolic syndrome in the Japanese population.
Diabetes care 2006;29(5):1123-4.
2006: Tomoko Takamiya; Takashi Kadowaki; Wahid R Zaky; Hirotsugu Ueshima; Rhobert W Evans; Tomonori Okamura; Atsunori Kashiwagi; Yasuyuki Nakamura; Yoshiyuki Kita; Russell P Tracy; Lewis H Kuller; Akira Sekikawa
The determinants of plasma plasminogen activator inhibitor-1 levels differ for American and Japanese men aged 40-49.
Diabetes research and clinical practice 2006;72(2):176-82.
2006: Momoko Horikoshi; Kazuo Hara; Jun Ohashi; Kazuaki Miyake; Katsushi Tokunaga; Chikako Ito; Masato Kasuga; Ryozo Nagai; Takashi Kadowaki
A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population.
Diabetes 2006;55(4):919-23.
2006: Naoto Kubota; Yasuo Terauchi; Tetsuya Kubota; Hiroki Kumagai; Shinsuke Itoh; Hidemi Satoh; Wataru Yano; Hitomi Ogata; Kumpei Tokuyama; Iseki Takamoto; Tomoka Mineyama; Michiro Ishikawa; Masao Moroi; Kaoru Sugi; Toshimasa Yamauchi; Kohjiro Ueki; Kazuyuki Tobe; Tetsuo Noda; Ryozo Nagai; Takashi Kadowaki
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways.
The Journal of biological chemistry 2006;281(13):8748-55.
2006: Kazuyuki Tobe; Toshimasa Yamauchi; Naoto Kubota; Kazuo Hara; Kohjiro Ueki; Takashi Kadowaki
[Pathogenesis of metabolic syndrome].
Seikagaku. The Journal of Japanese Biochemical Society 2006;78(3):208-20.
2006: Takashi Kadowaki; Hideyuki Kanda; Makoto Watanabe; Akira Okayama; Naomi Miyamatsu; Tomonori Okamura; Takehito Hayakawa; Kayoko Hishida; Yoshikuni Kita; Hirotsugu Ueshima
Are comprehensive environmental changes as effective as health education for smoking cessation?
Tobacco control 2006;15(1):26-9.
2006: Ryo Takeda; Hiroaki Nishimatsu; Etsu Suzuki; Hiroshi Satonaka; Daisuke Nagata; Shigeyoshi Oba; Masataka Sata; Masao Takahashi; Yuji Yamamoto; Yasuo Terauchi; Takashi Kadowaki; Kenji Kangawa; Tadaichi Kitamura; Ryozo Nagai; Yasunobu Hirata
Ghrelin improves renal function in mice with ischemic acute renal failure.
Journal of the American Society of Nephrology : JASN 2006;17(1):113-21.
2006: Naoyuki Iso-o; Hiroshi Noto; Masumi Hara; Masako Togo; Ken Karasawa; Noriko Ohashi; Eisei Noiri; Yoshiaki Hashimoto; Takashi Kadowaki; Satoshi Kimura; Tsuyoshi Watanabe; Kazuhisa Tsukamoto
Adenovirus-mediated gene transfer and lipoprotein-mediated protein delivery of plasma PAF-AH ameliorates proteinuria in rat model of glomerulosclerosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(1):118-26.
2006: Tomonori Okamura; Takehito Hayakawa; Takashi Kadowaki; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
The inverse relationship between serum high-density lipoprotein cholesterol level and all-cause mortality in a 9.6-year follow-up study in the Japanese general population.
Atherosclerosis 2006;184(1):143-50.
2005: Atsushi Tsuchida; Toshimasa Yamauchi; Sato Takekawa; Yusuke Hada; Yusuke Ito; Toshiyuki Maki; Takashi Kadowaki
Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination.
Diabetes 2005;54(12):3358-70.
2005: Koshi Nakamura; Tomonori Okamura; Hideyuki Kanda; Takehito Hayakawa; Takashi Kadowaki; Akira Okayama; Hirotsugu Ueshima
Impact of hypertension on medical economics: A 10-year follow-up study of national health insurance in Shiga, Japan.
Hypertension research : official journal of the Japanese Society of Hypertension 2005;28(11):859-64.
2005: Motofumi Suzuki; Mohammed Rafiqul Islam Mamun; Kazuo Hara; Takeshi Ozeki; Yasuhiko Yamada; Takashi Kadowaki; Hidetoshi Honda; Yoshitsugu Yanagihara; Yoichi Minagawa Ito; Shuji Kameyama; Nobutaka Ohta; Takayuki Hosoi; Tomio Arai; Motoji Sawabe; Takumi Takeuchi; Satoru Takahashi; Tadaichi Kitamura
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progression-free survival in prostate cancer patients treated with estramustine phosphate.
European urology 2005;48(5):752-9.
2005: Kohjiro Ueki; Takashi Kadowaki; C Ronald Kahn
Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;33(2):185-92.
2005: Heying Zhou; Yuichiro Yamada; Katsushi Tsukiyama; Kazumasa Miyawaki; Masaya Hosokawa; Kazuaki Nagashima; Kentaro Toyoda; Rei Naitoh; Wataru Mizunoya; Tohru Fushiki; Takashi Kadowaki; Yutaka Seino
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action.
Biochemical and biophysical research communications 2005;335(3):937-42.
2005: Shinji Tamaki; Yasuyuki Nakamura; Yasuharu Tabara; Tomonori Okamura; Yoshikuni Kita; Takashi Kadowaki; Yasuyuki Tsujita; Minoru Horie; Tetsuro Miki; Hirotsugu Ueshima
Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effects on hypertension in a Japanese sample: The Shigaraki Study.
Hypertension research : official journal of the Japanese Society of Hypertension 2005;28(8):645-50.
2005: Yuho Najima; Naoya Yahagi; Yoshinori Takeuchi; Takashi Matsuzaka; Motohiro Sekiya; Yoshimi Nakagawa; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Sachiko Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.
The Journal of biological chemistry 2005;280(30):27523-32.
2005: Kazuo Hara; Momoko Horikoshi; Hiroshi Kitazato; T Yamauchi; Chikako Ito; Mitsuhiko Noda; Jun Ohashi; philippe froguel; Katsushi Tokunaga; Ryozo Nagai; Takashi Kadowaki
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.
Diabetologia 2005;48(7):1307-14.
2005: Miho Ohsugi; Kazuyuki Tobe; Tetsuya Kubota; Naoto Kubota; Yasuo Terauchi; Takashi Kadowaki
[Gene targeting approaches for diabetes research].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 6():111-24.
2005: Ritsuko Yamamoto-Honda; Takashi Kadowaki
[Protein kinase C activation and diabetic complications].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 6():67-72.
2005: Jie Lu; Kazuhiro Imamura; Sachiyo Nomura; Ken-ichi Mafune; Atsushi Nakajima; Takashi Kadowaki; Naoto Kubota; Yasuo Terauchi; Genichiro Ishii; Atsushi Ochiai; Hiroyasu Esumi; Michio Kaminishi
Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice.
Cancer research 2005;65(11):4769-74.
2005: Naoya Yahagi; Hitoshi Shimano; Kiyoshi Hasegawa; Ken Ohashi; Takashi Matsuzaka; Yuho Najima; Motohiro Sekiya; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Kenichi Ohashi; Ryozo Nagai; Shun Ishibashi; Takashi Kadowaki; Makuuchi Masatoshi; Shin Ohnishi; Jun-ichi Osuga; Nobuhiro Yamada
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.
European journal of cancer (Oxford, England : 1990) 2005;41(9):1316-22.
2005: Masayuki Yamaguchi; Naoshi Ogata; Yusuke Shinoda; Toru Akune; Satoru Kamekura; Yasuo Terauchi; Takashi Kadowaki; Kazuto Hoshi; Ung-il Chung; Kozo Nakamura; Hiroshi Kawaguchi
Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice.
Endocrinology 2005;146(6):2620-8.
2005: Takashi Kadowaki; Toshimasa Yamauchi
Adiponectin and adiponectin receptors.
Endocrine reviews 2005;26(3):439-51.
2005: Yasuo Terauchi; Takashi Kadowaki
[PPAR and diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(4):623-9.
2005: Takashi Kadowaki
[Recent advances in PPARs research--basic and clinical aspects].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(4):539-48.
2005: Hiroko H Dodge; Takashi Kadowaki; Takehito Hayakawa; Masanobu Yamakawa; Akira Sekikawa; Hirotugu Ueshima
Cognitive impairment as a strong predictor of incident disability in specific ADL-IADL tasks among community-dwelling elders: the Azuchi Study.
The Gerontologist 2005;45(2):222-30.
2005: Kazuo Hara; Toshimasa Yamauchi; Takashi Kadowaki
Adiponectin: an adipokine linking adipocytes and type 2 diabetes in humans.
Current diabetes reports 2005;5(2):136-40.
2005: Naomi Miyamatsu; Takashi Kadowaki; Tomonori Okamura; Takehito Hayakawa; Yoshikuni Kita; Akira Okayama; Yasuyuki Nakamura; I Oki; Hirotsugu Ueshima
Different effects of blood pressure on mortality from stroke subtypes depending on BMI levels: a 19-year cohort study in the Japanese general population--NIPPON DATA80.
Journal of human hypertension 2005;19(4):285-91.
2005: Ryo Suzuki; Kazuyuki Tobe; Masashi Aoyama; Kentaro Sakamoto; Miho Ohsugi; Nozomu Kamei; Shigeyuki Nemoto; Atsushi Inoue; Yusuke Ito; Shoko Uchida; Kazuo Hara; Toshimasa Yamauchi; Naoto Kubota; Yasuo Terauchi; Takashi Kadowaki
Expression of DGAT2 in white adipose tissue is regulated by central leptin action.
The Journal of biological chemistry 2005;280(5):3331-7.
2005: Kazuyuki Tobe; Shigeyuki Nemoto; Takashi Kadowaki
[Molecular mechanism of insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():114-30.
2005: Yasuo Terauchi; Takashi Kadowaki
[Impaired glucose tolerance (IGT): current understanding and future research directions].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():21-6.
2005: Motofumi Suzuki; Satoru Muto; Kazuo Hara; Takeshi Ozeki; Yasuhiko Yamada; Takashi Kadowaki; Kyoichi Tomita; Shuji Kameyama; Tadaichi Kitamura
Single-nucleotide polymorphisms in the 17beta-hydroxysteroid dehydrogenase genes might predict the risk of side-effects of estramustine phosphate sodium in prostate cancer patients.
International journal of urology : official journal of the Japanese Urological Association 2005;12(2):166-72.
2005: Atsushi Tsuchida; Toshimasa Yamauchi; Takashi Kadowaki
Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin.
Journal of pharmacological sciences 2005;97(2):164-70.
2005: Akira Sekikawa; Hirotsugu Ueshima; Wahid R Zaky; Takashi Kadowaki; Daniel Edmundowicz; Tomonori Okamura; Kim Sutton-Tyrrell; Yasuyuki Nakamura; Katsuya Egawa; Hideyuki Kanda; Atsunori Kashiwagi; Yoshiyuki Kita; Hiroshi Maegawa; Kenichi Mitsunami; Kiyoshi Murata; Yoshihiko Nishio; Shinji Tamaki; Yoshiki Ueno; Lewis H Kuller
Much lower prevalence of coronary calcium detected by electron-beam computed tomography among men aged 40-49 in Japan than in the US, despite a less favorable profile of major risk factors.
International journal of epidemiology 2005;34(1):173-9.
2005: Hironori Waki; Toshimasa Yamauchi; Junji Kamon; Shunbun Kita; Yusuke Ito; Yusuke Hada; Shoko Uchida; Atsushi Tsuchida; Sato Takekawa; Takashi Kadowaki
Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1.
Endocrinology 2005;146(2):790-6.
2005: H Kanda; Yoshikuni Kita; Tomonori Okamura; Takashi Kadowaki; Y Yoshida; Yasuyuki Nakamura; Hirotsugu Ueshima
What factors are associated with high plasma B-type natriuretic peptide levels in a general Japanese population?
Journal of human hypertension 2005;19(2):165-72.
2005: Yumiko Oishi; Ichiro Manabe; Kazuyuki Tobe; Kensuke Tsushima; Takayuki Shindo; Katsuhito Fujiu; Go Nishimura; Koji Maemura; Toshimasa Yamauchi; Naoto Kubota; Ryo Suzuki; Toshio Kitamura; Shizuo Akira; Takashi Kadowaki; Ryozo Nagai
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Cell metabolism 2005;1(1):27-39.
2005: Hiroshi Kawaguchi; Toru Akune; Masayuki Yamaguchi; Shinsuke Ohba; Naoshi Ogata; Ung-il Chung; Naoto Kubota; Yasuo Terauchi; Takashi Kadowaki; Kozo Nakamura
Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells.
Journal of bone and mineral metabolism 2005;23(4):275-9.
2004: Tomoko Takamiya; Wahid R Zaky; Daniel Edmundowics; Takashi Kadowaki; Hirotsugu Ueshima; Lewis H Kuller; Akira Sekikawa
World Health Organization-defined metabolic syndrome is a better predictor of coronary calcium than the adult treatment panel III criteria in American men aged 40-49 years.
Diabetes care 2004;27(12):2977-9.
2004: Yasushi Kaburagi; Ryo Yamashita; Yuzuru Ito; Hitoshi Okochi; Ritsuko Yamamoto-Honda; Kazuki Yasuda; Hisahiko Sekihara; Takehiko Sasazuki; Takashi Kadowaki; Yoshio Yazaki
Insulin-induced cell cycle progression is impaired in chinese hamster ovary cells overexpressing insulin receptor substrate-3.
Endocrinology 2004;145(12):5862-74.
2004: Tomonori Okamura; Takehito Hayakawa; Takashi Kadowaki; Yoshikuni Kita; Akira Okayama; Paul Elliott; Hirotsugu Ueshima
A combination of serum low albumin and above-average cholesterol level was associated with excess mortality.
Journal of clinical epidemiology 2004;57(11):1188-95.
2004: Junji Matsui; Yasuo Terauchi; Naoto Kubota; Iseki Takamoto; Kazuhiro Eto; Tokuyuki Yamashita; Kajuro Komeda; Toshimasa Yamauchi; Junji Kamon; Shunbun Kita; Mitsuhiko Noda; Takashi Kadowaki
Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet.
Diabetes 2004;53(11):2844-54.
2004: Junji Kamon; Toshimasa Yamauchi; Susumu Muto; Sato Takekawa; Yusuke Ito; Yusuke Hada; Wataru Ogawa; Akiko Itai; Masato Kasuga; Kazuyuki Tobe; Takashi Kadowaki
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
Biochemical and biophysical research communications 2004;323(1):242-8.
2004: Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; Wataru Yano; Ryo Suzuki; Kohjiro Ueki; Iseki Takamoto; Hidemi Satoh; Toshiyuki Maki; Tetsuya Kubota; Masao Moroi; Miki Okada-Iwabu; Osamu Ezaki; Ryozo Nagai; Yoichi Ueta; Takashi Kadowaki; Tetsuo Noda
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
The Journal of clinical investigation 2004;114(7):917-27.
2004: Yasuo Terauchi; Junji Matsui; Junji Kamon; Toshimasa Yamauchi; Naoto Kubota; Kajuro Komeda; Shinichi Aizawa; Yasuo Akanuma; Motowo Tomita; Takashi Kadowaki
Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase.
Diabetes 2004;53(9):2261-70.
2004: Shunsaku Mizushima; Kenji Ohshige; Junko Watanabe; Maki Kimura; Takashi Kadowaki; Yasunori Nakamura; Osamu Tochikubo; Hirotsugu Ueshima
Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men.
American journal of hypertension 2004;17(8):701-6.
2004: Hirotsugu Ueshima; Sohel Reza Choudhury; Akira Okayama; Takehito Hayakawa; Yoshikuni Kita; Takashi Kadowaki; Tomonori Okamura; Masumi Minowa; Osamu Iimura
Cigarette smoking as a risk factor for stroke death in Japan: NIPPON DATA80.
Stroke; a journal of cerebral circulation 2004;35(8):1836-41.
2004: Tokuyuki Yamashita; Kazuhiro Eto; Yukiko Okazaki; Shigeo Yamashita; Toshimasa Yamauchi; Nobuo Sekine; Ryozo Nagai; Mitsuhiko Noda; Takashi Kadowaki
Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c.
Endocrinology 2004;145(8):3566-77.
2004: Yoshiaki Tamura; Jun-ichi Osuga; Hideki Adachi; Ryuichi Tozawa; Yasukazu Takanezawa; Ken Ohashi; Naoya Yahagi; Motohiro Sekiya; Hiroaki Okazaki; Sachiko Tomita; Yoko Iizuka; Hiroyuki Koizumi; Toshihiro Inaba; Hiroaki Yagyu; Nobuo Kamada; Hiroshi Suzuki; Hitoshi Shimano; Takashi Kadowaki; Masafumi Tsujimoto; Hiroyuki Arai; Nobuhiro Yamada; Shun Ishibashi
Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.
The Journal of biological chemistry 2004;279(30):30938-44.
2004: Atsushi Tsuchida; Toshimasa Yamauchi; Yusuke Ito; Yusuke Hada; Toshiyuki Maki; Sato Takekawa; Junji Kamon; Masaki Kobayashi; Ryo Suzuki; Kazuo Hara; Naoto Kubota; Yasuo Terauchi; philippe froguel; Jun Nakae; Masato Kasuga; Domenico Accili; Kazuyuki Tobe; Kohjiro Ueki; Ryozo Nagai; Takashi Kadowaki
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.
The Journal of biological chemistry 2004;279(29):30817-22.
2004: Takashi Kadowaki; Tomonori Okamura; Tsutae Funakoshi; Akira Okayama; Hideyuki Kanda; Naomi Miyamatsu; Yoshikuni Kita; Hirotsugu Ueshima
Effectiveness of annual interventions for smoking cessation in an occupational setting in Japan.
Environmental health and preventive medicine 2004;9(4):161-4.
2004: Tomonori Okamura; Akira Okayama; Toru Takebayashi; Taichiro Tanaka; Hirotsugu Ueshima; Hiroshi Yamato; Katsushi Yoshita; Takashi Kadowaki; Hideaki Nakagawa
Methodological issues for a large-scale intervention trial of lifestyle modification: Interim assessment of the high-risk and population strategy for occupational health promotion (HIPOP-OHP) study.
Environmental health and preventive medicine 2004;9(4):137-43.
2004: Nagako Okuda; Tomonori Okamura; Takashi Kadowaki; Taichiro Tanaka; Hirotsugu Ueshima
[Weight-control intervention in overweight subjects at high risk of cardiovascular disease: a trial of a public health practical training program in a medical school].
[Nihon kōshū eisei zasshi] Japanese journal of public health 2004;51(7):552-60.
2004: Yasuyuki Nakamura; Tomonori Okamura; Shinji Tamaki; Takashi Kadowaki; Takehito Hayakawa; Yoshikuni Kita; Akira Okayama; Hirotsugu Ueshima
Egg consumption, serum cholesterol, and cause-specific and all-cause mortality: the National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged, 1980 (NIPPON DATA80).
The American journal of clinical nutrition 2004;80(1):58-63.
2004: Tomonori Okamura; Taichiro Tanaka; A Babazono; Katsushi Yoshita; N Chiba; T Takebayashi; Hideaki Nakagawa; H Yamato; K Miura; Junko Tamaki; Takashi Kadowaki; Akira Okayama; Hirotsugu Ueshima
The high-risk and population strategy for occupational health promotion (HIPOP-OHP) study: study design and cardiovascular risk factors at the baseline survey.
Journal of human hypertension 2004;18(7):475-85.
2004: Ryo Suzuki; Kazuyuki Tobe; Masashi Aoyama; Atsushi Inoue; Kentaro Sakamoto; Toshimasa Yamauchi; Junji Kamon; Naoto Kubota; Yasuo Terauchi; Hironobu Yoshimatsu; Munehide Matsuhisa; Shoichiro Nagasaka; Hitomi Ogata; Kumpei Tokuyama; Ryozo Nagai; Takashi Kadowaki
Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice.
The Journal of biological chemistry 2004;279(24):25039-49.
2004: Toshimasa Yamauchi; Takashi Kadowaki
[Molecular structure related to the expression of insulin resistance and its evaluation].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(6):1016-9.
2004: Tomonori Okamura; Takehito Hayakawa; Takashi Kadowaki; Yoshikuni Kita; Akira Okayama; Paul Elliott; Hirotsugu Ueshima
Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population.
American heart journal 2004;147(6):1024-32.
2004: Naoya Yahagi; Hitoshi Shimano; Takashi Matsuzaka; Motohiro Sekiya; Yuho Najima; Sachiko Okazaki; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Noriyuki Inoue; Yoshimi Nakagawa; Yoshinori Takeuchi; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
p53 involvement in the pathogenesis of fatty liver disease.
The Journal of biological chemistry 2004;279(20):20571-5.
2004: Takashi Shimoaka; Satoru Kamekura; Hirotaka Chikuda; Kazuto Hoshi; Ung-il Chung; Toru Akune; Zenjiro Maruyama; Toshihisa Komori; Michihiro Matsumoto; Wataru Ogawa; Yasuo Terauchi; Takashi Kadowaki; Kozo Nakamura; Hiroshi Kawaguchi
Impairment of bone healing by insulin receptor substrate-1 deficiency.
The Journal of biological chemistry 2004;279(15):15314-22.
2004: Tomonori Okamura; Yuri Moriyama; Takashi Kadowaki; Hideyuki Kanda; Hirotsugu Ueshima
Non-invasive measurement of brachial-ankle pulse wave velocity is associated with serum C-reactive protein but not with alpha-tocopherol in Japanese middle-aged male workers.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(3):173-80.
2004: Toru Akune; Shinsuke Ohba; Satoru Kamekura; Masayuki Yamaguchi; Ung-il Chung; Naoto Kubota; Yasuo Terauchi; Yoshifumi Harada; Yoshiaki Azuma; Kozo Nakamura; Takashi Kadowaki; Hiroshi Kawaguchi
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors.
The Journal of clinical investigation 2004;113(6):846-55.
2004: Iseki Takamoto; Takashi Kadowaki
[Diabetes and osteoporosis].
Clinical calcium 2004;14(2):255-61.
2004: Kazuto Hoshi; Naoshi Ogata; Takashi Shimoaka; Yasuo Terauchi; Takashi Kadowaki; Shin-Ichi Kenmotsu; Ung-il Chung; Hedehiro Ozawa; Kozo Nakamura; Hiroshi Kawaguchi
Deficiency of insulin receptor substrate-1 impairs skeletal growth through early closure of epiphyseal cartilage.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(2):214-23.
2004: Tomonori Okamura; Taichiro Tanaka; Katsushi Yoshita; N Chiba; T Takebayashi; Y Kikuchi; Junko Tamaki; Unai Tamura; Junko Minai; Takashi Kadowaki; K Miura; Hideaki Nakagawa; S Tanihara; Akira Okayama; Hirotsugu Ueshima
Specific alcoholic beverage and blood pressure in a middle-aged Japanese population: the High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) Study.
Journal of human hypertension 2004;18(1):9-16.
2003: Toshimasa Yamauchi; Kazuo Hara; Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; philippe froguel; Ryozo Nagai; Takashi Kadowaki
Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine.
Current drug targets. Immune, endocrine and metabolic disorders 2003;3(4):243-54.
2003: Kohtaro Minami; Mizuo Morita; Atsunori Saraya; Hideki Yano; Yasuo Terauchi; Takashi Miki; Takayuki Kuriyama; Takashi Kadowaki; Susumu Seino
ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling.
American journal of physiology. Endocrinology and metabolism 2003;285(6):E1289-96.
2003: Takashi Kadowaki; Kazuo Hara; Toshimasa Yamauchi; Yasuo Terauchi; Kazuyuki Tobe; Ryozo Nagai
Molecular mechanism of insulin resistance and obesity.
Experimental biology and medicine (Maywood, N.J.) 2003;228(10):1111-7.
2003: Ryo Suzuki; Kazuyuki Tobe; Yasuo Terauchi; Kajuro Komeda; Naoto Kubota; Kazuhiro Eto; Toshimasa Yamauchi; Kousuke Azuma; Hideaki Kaneto; Takashi Taguchi; Teiichiro Koga; Michael S German; Hirotaka Watada; Ryuzo Kawamori; Christopher V E Wright; Yoshitaka Kajimoto; Satoshi Kimura; Ryozo Nagai; Takashi Kadowaki
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
The Journal of biological chemistry 2003;278(44):43691-8.
2003: Hironori Waki; Toshimasa Yamauchi; Junji Kamon; Yusuke Ito; Shoko Uchida; Shunbun Kita; Kazuo Hara; Yusuke Hada; Francis Vasseur; philippe froguel; Satoshi Kimura; Ryozo Nagai; Takashi Kadowaki
Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.
The Journal of biological chemistry 2003;278(41):40352-63.
2003: Kazuo Hara; Takashi Kadowaki
[Genetic susceptibility of type 2 diabetes].
Seikagaku. The Journal of Japanese Biochemical Society 2003;75(10):1345-60.
2003: Kazuo Hara; Toshimasa Yamauchi; Naoto Kubota; Kazuyuki Tobe; Tsutomu Yamazaki; Ryozo Nagai; Takashi Kadowaki
[The role of PPARgamma in the onset of type 2 diabetes].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(4):317-24.
2003: Junji Kamon; Toshimasa Yamauchi; Yasuo Terauchi; Naoto Kubota; Takashi Kadowaki
[The mechanisms by which PPARgamma and adiponectin regulate glucose and lipid metabolism].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(4):294-300.
2003: Yukiyoshi Fujita; Yasuhiko Yamada; Mikihiro Kusama; Toshimasa Yamauchi; Junji Kamon; Takashi Kadowaki; Tatsuji Iga
Sex differences in the pharmacokinetics of pioglitazone in rats.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2003;136(1):85-94.
2003: Minami Abe; Masataka Sata; Hiroaki Nishimatsu; Daisuke Nagata; Etsu Suzuki; Yasuo Terauchi; Takashi Kadowaki; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo; Yasunobu Hirata; Ryozo Nagai
Adrenomedullin augments collateral development in response to acute ischemia.
Biochemical and biophysical research communications 2003;306(1):10-5.
2003: Toshimasa Yamauchi; Junji Kamon; Yusuke Ito; Atsushi Tsuchida; Takehiko Yokomizo; Shunbun Kita; Takuya Sugiyama; Makoto Miyagishi; Kazuo Hara; Masaki Tsunoda; Koji Murakami; Toshiaki Ohteki; Shoko Uchida; Sato Takekawa; Hironori Waki; Nelson H Tsuno; Yoichi Shibata; Yasuo Terauchi; philippe froguel; Kazuyuki Tobe; Shigeo Koyasu; Kazunari Taira; Toshio Kitamura; Takao Shimizu; Ryozo Nagai; Takashi Kadowaki
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
Nature 2003;423(6941):762-9.
2003: Yasuo Terauchi; Junji Matsui; Ryo Suzuki; Naoto Kubota; Kajuro Komeda; Shinichi Aizawa; Kazuhiro Eto; Satoshi Kimura; Ryozo Nagai; Kazuyuki Tobe; Gustav E Lienhard; Takashi Kadowaki
Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.
The Journal of biological chemistry 2003;278(16):14284-90.
2003: Akira Sekikawa; Tomonori Okamura; Takashi Kadowaki; Kenichi Mitsunami; Kiyoshi Murata; Atsunori Kashiwagi; Yasuyuki Nakamura; Hideyuki Kanda; Daniel Edmundowicz; Kim Sutton-Tyrrell; J David Curb; Lewis H Kuller; Hirotsugu Ueshima
[Electron-beam computed tomography for identification of high-risk persons in primary prevention of coronary heart disease in the United States and its implication for Japan].
[Nihon kōshū eisei zasshi] Japanese journal of public health 2003;50(3):183-93.
2003: Céline Populaire; Yasumichi Mori; Christian Dina; Francis Vasseur; Martine Vaxillaire; Takashi Kadowaki; philippe froguel
Does the -11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families?
Diabetologia 2003;46(3):443-5.
2003: Toshimasa Yamauchi; Junji Kamon; Hironori Waki; Yasushi Imai; Nobuhiro Shimozawa; Kyouji Hioki; Shoko Uchida; Yusuke Ito; Keisuke Takakuwa; Junji Matsui; Makoto Takata; Kazuhiro Eto; Yasuo Terauchi; Kajuro Komeda; Masaki Tsunoda; Koji Murakami; Yasuyuki Ohnishi; Takeshi Naitoh; Kenichi Yamamura; Yoshito Ueyama; philippe froguel; Satoshi Kimura; Ryozo Nagai; Takashi Kadowaki
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.
The Journal of biological chemistry 2003;278(4):2461-8.
2003: Yasushi Kaburagi; Shinobu Satoh; Ritsuko Yamamoto-Honda; Yuzuru Ito; Yasuo Akanuma; Hisahiko Sekihara; Kazuki Yasuda; Takehiko Sasazuki; Takashi Kadowaki; Yoshio Yazaki
Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis.
Biochemical and biophysical research communications 2003;300(2):371-7.
2003: Kazuo Hara; Kazuhiko Ohe; Takashi Kadowaki; Naoya Kato; Yasushi Imai; Katsushi Tokunaga; Ryozo Nagai; Masao Omata
Establishment of a method of anonymization of DNA samples in genetic research.
Journal of human genetics 2003;48(6):327-30.
2003: Hideyuki Kanda; Tomonori Okamura; Takashi Kadowaki; Takehito Hayakawa; Yoshikuni Kita; Hirotsugu Ueshima
[Smoking scenes in Japanese television dramas].
[Nihon kōshū eisei zasshi] Japanese journal of public health 2003;50(1):62-70.
2003: Kazuyuki Tobe; Shohji Asai; Koozi Matuoka; Tadashi Yamamoto; Kazuhiro Chida; Yasushi Kaburagi; Yasuo Akanuma; Toshio Kuroki; Tadaomi Takenawa; Satoshi Kimura; Ryozo Nagai; Takashi Kadowaki
Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3-kinase signalling.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(1):29-40.
2002: Kazuhiro Eto; Tokuyuki Yamashita; Junji Matsui; Yasuo Terauchi; Mitsuhiko Noda; Takashi Kadowaki
Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion.
Diabetes 2002;51 Suppl 3():S414-20.
2002: Kenji Amamoto; Tomonori Okamura; Shinji Tamaki; Yoshikuni Kita; Yasuyuki Tsujita; Takashi Kadowaki; Yasuyuki Nakamura; Hirotsugu Ueshima
Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):857-64.
2002: Shinji Tamaki; Yasuyuki Nakamura; Yasuyuki Tsujita; Akihiko Nozaki; Kenji Amamoto; Takashi Kadowaki; Yoshikuni Kita; Tomonori Okamura; Naoharu Iwai; Masahiko Kinoshita; Hirotsugu Ueshima
Polymorphism of the angiotensin converting enzyme gene and blood pressure in a Japanese general population (the Shigaraki Study).
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):843-8.
2002: Toshimasa Yamauchi; Junji Kamon; Yasuhiko Minokoshi; Yusuke Ito; Hironori Waki; Shoko Uchida; Shigeo Yamashita; Mitsuhiko Noda; Shunbun Kita; Keisuke Ueki; Kazuhiro Eto; Yasuo Akanuma; philippe froguel; Fabienne Foufelle; pascal ferre; David Carling; Satoshi Kimura; Ryozo Nagai; B B Kahn; Takashi Kadowaki
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.
Nature medicine 2002;8(11):1288-95.
2002: Mitsuhiko Noda; Shigeo Yamashita; Noriko Takahashi; Kazuhiro Eto; Lin-Ming Shen; Kazuo Izumi; Samira Daniel; Yoshiharu Tsubamoto; Tomomi Nemoto; Masamitsu Iino; Haruo Kasai; Geoffrey W G Sharp; Takashi Kadowaki
Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription.
The Journal of biological chemistry 2002;277(44):41817-26.
2002: Toru Akune; Naoshi Ogata; Kazuto Hoshi; Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; Hideko Takagi; Yoshiaki Azuma; Takashi Kadowaki; Kozo Nakamura; Hiroshi Kawaguchi
Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts.
The Journal of cell biology 2002;159(1):147-56.
2002: Takashi Kadowaki
[Perspective for personalized medicine for diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 10():729-37.
2002: Takashi Kadowaki
[Importance of animal models by gene targeting in diabetes research].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 10():681-6.
2002: Atsushi Inoue; Kazuyuki Tobe; Ryo Suzuki; Takashi Kadowaki
[Glucose metabolism in adipose tissue].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 10():673-80.
2002: Kazuo Hara; Mitsuhiko Noda; Hironori Waki; Kazuyuki Tobe; Toshimasa Yamauchi; Hiroko Kadowaki; Hiroaki Satou; Kazuhisa Tsukamoto; Shinya Nagamatsu; Kazuhiro Yamagata; Yuji Matsuzawa; Yasuo Akanuma; Satoshi Kimura; Takashi Kadowaki
Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene.
Internal medicine (Tokyo, Japan) 2002;41(10):848-52.
2002: Yuko Yamakoshi; Hiroshi Fukasawa; Toshimasa Yamauchi; Hironori Waki; Takashi Kadowaki; Koichi Shudo; Hiroyuki Kagechi
Determination of endogenous levels of retinoic acid isomers in type II diabetes mellitus patients. Possible correlation with HbA1c values.
Biological & pharmaceutical bulletin 2002;25(10):1268-71.
2002: Toshimasa Yamauchi; Takashi Kadowaki
[Mechanisms by which PPAR gamma modulators regulate insulin sensitivity].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 9():578-87.
2002: Takashi Kadowaki
[Perspective for development of insulin sensitizers].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 9():566-72.
2002: Yasuo Terauchi; Takashi Kadowaki
[Knockout mouse models for type 2 diabetes. Mice with insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 8():64-9.
2002: Yasuo Terauchi; Takashi Kadowaki
[Knockout mouse models for type 2 diabetes. Mice with impaired insulin secretion].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 8():58-63.
2002: Kazuo Hara; Takashi Kadowaki
[Genomics of type 2 diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 8():283-9.
2002: Takayuki Shindo; Ichiro Manabe; Yasushi Fukushima; Kazuyuki Tobe; Kenichi Aizawa; Saku Miyamoto; Keiko Kawai-Kowase; Nobuo Moriyama; Yasushi Imai; Hayato Kawakami; Hiroaki Nishimatsu; Takashi Ishikawa; Toru Suzuki; Hiroyuki Morita; Koji Maemura; Masataka Sata; Yasunobu Hirata; Masayuki Komukai; Hiroyuki Kagechika; Takashi Kadowaki; Masahiko Kurabayashi; Ryozo Nagai
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Nature medicine 2002;8(8):856-63.
2002: Naoto Kubota; Yasuo Terauchi; Toshimasa Yamauchi; Tetsuya Kubota; Masao Moroi; Junji Matsui; Kazuhiro Eto; Tokuyuki Yamashita; Junji Kamon; Hidemi Satoh; Wataru Yano; philippe froguel; Ryozo Nagai; Satoshi Kimura; Takashi Kadowaki; Tetsuo Noda
Disruption of adiponectin causes insulin resistance and neointimal formation.
The Journal of biological chemistry 2002;277(29):25863-6.
2002: Junji Kamon; Toshimasa Yamauchi; Takashi Kadowaki
[PPAR family (PPAR alpha, PPAR delta, PPAR gamma)].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():593-600.
2002: Kazuhiro Eto; Takashi Kadowaki
[Glucokinase].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():523-34.
2002: Takashi Kadowaki; Kazuo Hara; Yasumichi Mori
[Current status of analysis of type 2 diabetes genes].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():477-86.
2002: Kazuhiro Eto; Takashi Kadowaki
[Role of NADH shuttle system in glucose-stimulated insulin secretion].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():190-207.
2002: Yasuo Terauchi; Takashi Kadowaki
Insights into molecular pathogenesis of type 2 diabetes from knockout mouse models.
Endocrine journal 2002;49(3):247-63.
2002: Xu Mao; Tomonori Okamura; Sohel Reza Choudhury; Yoshikuni Kita; Takashi Kadowaki; Akira Okayama; Isao Niki; Hirotsugu Ueshima
What unfavorable factors are associated with low serum total cholesterol in a Japanese population?
Journal of epidemiology / Japan Epidemiological Association 2002;12(3):271-9.
2002: Kazuo Hara; Kazuyuki Tobe; Terumasa Okada; Hiroko Kadowaki; Yasuo Akanuma; Chikako Ito; Satoshi Kimura; Takashi Kadowaki
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.
Diabetologia 2002;45(5):740-3.
2002: Yasumichi Mori; Shuichi Otabe; Christian Dina; Kazuki Yasuda; Céline Populaire; Cécile Lecoeur; Vincent Vatin; Emmanuelle Durand; Kazuo Hara; Terumasa Okada; Kazuyuki Tobe; Philippe Boutin; Takashi Kadowaki; philippe froguel
Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.
Diabetes 2002;51(4):1247-55.
2002: Masayuki Asakawa; Hiroyuki Takano; Toshio Nagai; Hiroki Uozumi; Hiroshi Hasegawa; Naoto Kubota; Toshihiro Saito; Yoshiaki Masuda; Takashi Kadowaki; Issei Komuro
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.
Circulation 2002;105(10):1240-6.
2002: Taichiro Tanaka; Tomonori Okamura; K Miura; Takashi Kadowaki; Hirotsugu Ueshima; Hideaki Nakagawa; T Hashimoto
A simple method to estimate populational 24-h urinary sodium and potassium excretion using a casual urine specimen.
Journal of human hypertension 2002;16(2):97-103.
2002: Toshimasa Yamauchi; Yuichi Oike; Junji Kamon; Hironori Waki; Kajuro Komeda; Atsushi Tsuchida; Yukari Date; Meng Xian Li; Hiroshi Miki; Yasuo Akanuma; Ryozo Nagai; Satoshi Kimura; Takeyori Saheki; Masamitsu Nakazato; Takeshi Naitoh; Kenichi Yamamura; Takashi Kadowaki
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice.
Nature genetics 2002;30(2):221-6.
2002: Kazuo Hara; Philippe Boutin; Yasumichi Mori; Kazuyuki Tobe; Christian Dina; Kazuki Yasuda; Toshimasa Yamauchi; Shuichi Otabe; Terumasa Okada; Kazuhiro Eto; Hiroko Kadowaki; Ryoko Hagura; Yasuo Akanuma; Yoshio Yazaki; Ryozo Nagai; Matsuo Taniyama; Koichi Matsubara; Madoka Yoda; Yasuko Nakano; Motowo Tomita; Satoshi Kimura; Chikako Ito; philippe froguel; Takashi Kadowaki
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.
Diabetes 2002;51(2):536-40.
2002: Takashi Kadowaki; Kazuo Hara; Naoto Kubota; Kazuyuki Tobe; Yasuo Terauchi; Toshimasa Yamauchi; Kazuhiro Eto; Hiroko Kadowaki; Mitsuhiko Noda; Ryoko Hagura; Yasuo Akanuma
The role of PPARgamma in high-fat diet-induced obesity and insulin resistance.
Journal of diabetes and its complications 2002;16(1):41-5.
2002: Kazuhiro Eto; Tokuyuki Yamashita; Yoshiharu Tsubamoto; Yasuo Terauchi; Kenzo Hirose; Naoto Kubota; Shigeo Yamashita; Junko Taka; Shinobu Satoh; Hisahiko Sekihara; Kazuyuki Tobe; Masamitsu Iino; Mitsuhiko Noda; Satoshi Kimura; Takashi Kadowaki
Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals.
Diabetes 2002;51(1):87-97.
2001: Tomonori Okamura; T Hayakawa; Takashi Kadowaki; Kenji Amamoto; Yoshikuni Kita; A Okayama; Hirotsugu Ueshima
[Estimated relative and absolute risk for cardiovascular disease according to alcohol consumption increase in Japanese general population].
Nihon Arukōru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 2001;36(6):586-95.
2001: Kiyoshi Setoguchi; Yoshikata Misaki; Yasuo Terauchi; Toshimasa Yamauchi; Kimito Kawahata; Takashi Kadowaki; Kazuhiko Yamamoto
Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis.
The Journal of clinical investigation 2001;108(11):1667-75.
2001: Toshimasa Yamauchi; Junji Kamon; Hironori Waki; Koji Murakami; Kiyoto Motojima; Kajuro Komeda; Tomohiro Ide; Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; Hiroshi Miki; Atsushi Tsuchida; Yasuo Akanuma; Ryozo Nagai; Satoshi Kimura; Takashi Kadowaki
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance.
The Journal of biological chemistry 2001;276(44):41245-54.
2001: Takashi Kadowaki
[PPAR gamma agonist and antagonist].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2001;118(5):321-6.
2001: Toshimasa Yamauchi; Takashi Kadowaki
[The molecular mechanisms by which PPAR gamma/RXR inhibitors improve insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(11):2245-54.
2001: Takashi Kadowaki
[A trend of insulin sensitizer which is under development].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(11):2186-90.
2001: Kazuyuki Tobe; Ryo Suzuki; Masashi Aoyama; Toshimasa Yamauchi; Junji Kamon; Naoto Kubota; Yasuo Terauchi; Junji Matsui; Yasuo Akanuma; Satoshi Kimura; J Tanaka; Masato Abe; J Ohsumi; Ryozo Nagai; Takashi Kadowaki
Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.
The Journal of biological chemistry 2001;276(42):38337-40.
2001: Toshimasa Yamauchi; Hironori Waki; Junji Kamon; Koji Murakami; Kiyoto Motojima; Kajuro Komeda; Hiroshi Miki; Naoto Kubota; Yasuo Terauchi; Atsushi Tsuchida; Nobuyo Tsuboyama-Kasaoka; N Yamauchi; Tomohiro Ide; W Hori; Shigeaki Kato; Masashi Fukayama; Yasuo Akanuma; Osamu Ezaki; Akiko Itai; Ryozo Nagai; Satoshi Kimura; Kazuyuki Tobe; Hiroyuki Kagechika; Koichi Shudo; Takashi Kadowaki
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
The Journal of clinical investigation 2001;108(7):1001-13.
2001: Yasushi Kaburagi; Shinobu Satoh; Ritsuko Yamamoto-Honda; T Ito; Keisuke Ueki; Yasuo Akanuma; Hisahiko Sekihara; Satoshi Kimura; Takashi Kadowaki
Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1.
Diabetologia 2001;44(8):992-1004.
2001: Toshimasa Yamauchi; Junji Kamon; Hironori Waki; Yasuo Terauchi; Naoto Kubota; Kazuo Hara; Yasumichi Mori; Tomohiro Ide; Koji Murakami; Nobuyo Tsuboyama-Kasaoka; Osamu Ezaki; Yasuo Akanuma; Oksana Gavrilova; C Vinson; Marc L Reitman; Hiroyuki Kagechika; Koichi Shudo; M Yoda; Y Nakano; Kazuyuki Tobe; Ryozo Nagai; Satoshi Kimura; Motowo Tomita; philippe froguel; Takashi Kadowaki
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Nature medicine 2001;7(8):941-6.
2001: Y Takahashi; M Noda; S Tsugane; Satoshi Kimura; Yasuo Akanuma; T Kuzuya; Y Ohashi; Takashi Kadowaki
Importance of standardization of hemoglobin A1c in the analysis of factors that predict hemoglobin A1c levels in non-diabetic residents of three distinct areas of Japan.
Diabetes research and clinical practice 2001;53(2):91-7.
2001: Y Gu; Yunzeng Zou; Ryuichi Aikawa; Doubun Hayashi; Sumiyo Kudoh; Toshimasa Yamauchi; Hiroki Uozumi; Weidong Zhu; Takashi Kadowaki; Yoshio Yazaki; Issei Komuro
Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes.
Molecular and cellular biochemistry 2001;223(1-2):35-46.
2001: Y Tsuji; Yasushi Kaburagi; Yasuo Terauchi; Shinobu Satoh; Naoto Kubota; H Tamemoto; Fredric B Kraemer; Hisahiko Sekihara; Shin Aizawa; Yasuo Akanuma; Kazuyuki Tobe; Satoshi Kimura; Takashi Kadowaki
Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice.
Diabetes 2001;50(6):1455-63.
2001: Takashi Kadowaki; Tomio Okamura; Hirotsugu Ueshima
[Lipid disorder and atherosclerosis caused by smoking].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():214-9.
2001: Yoshiharu Tsubamoto; Kazuhiro Eto; Mitsuhiko Noda; S Daniel; S Suga; Shigeo Yamashita; Haruo Kasai; M Wakui; Geoffrey W G Sharp; Satoshi Kimura; Takashi Kadowaki
Hexamminecobalt(III) chloride inhibits glucose-induced insulin secretion at the exocytotic process.
The Journal of biological chemistry 2001;276(5):2979-85.
2001: Toshimasa Yamauchi; Kazuo Hara; H Miki; Takashi Kadowaki
[The mechanisms by which PPAR gamma regulates fat storage and insulin sensitivity].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():489-97.
2001: Ritsuko Yamamoto-Honda; Yasuo Akanuma; Takashi Kadowaki
[Control of lipid metabolism by insulin].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():400-2.
2001: Terumasa Okada; Kazuyuki Tobe; Kazuo Hara; Kazuki Yasuda; Y Kawaguchi; H Ikegami; Chikako Ito; Takashi Kadowaki
Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects.
Diabetologia 2001;44(2):241-4.
2001: Kazuki Yasuda; N Koda; Hiroko Kadowaki; Y Ogawa; Satoshi Kimura; Takashi Kadowaki; Yasuo Akanuma
A Japanese case of congenital hyperinsulinism with hyperammonemia due to a mutation in glutamate dehydrogenase (GLUD1) gene.
Internal medicine (Tokyo, Japan) 2001;40(1):32-7.
2000: T Sugiyama; H Kumagai; Y Morikawa; Youichiro Wada; Akira Sugiyama; K Yasuda; N Yokoi; S Tamura; T Kojima; T Nosaka; E Senba; Satoshi Kimura; Takashi Kadowaki; Tsunenori Kodama; T Kitamura
A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro.
Biochemistry 2000;39(51):15817-25.
2000: Kazuo Hara; Naoto Kubota; Kazuyuki Tobe; Yasuo Terauchi; H Miki; Kajuro Komeda; H Tamemoto; Toshimasa Yamauchi; Ryoko Hagura; Chikako Ito; Yasuo Akanuma; Takashi Kadowaki
The role of PPARgamma as a thrifty gene both in mice and humans.
The British journal of nutrition 2000;84 Suppl 2():S235-9.
2000: Naoto Kubota; Kazuyuki Tobe; Yasuo Terauchi; Kazuhiro Eto; Toshimasa Yamauchi; Ryo Suzuki; Yoshiharu Tsubamoto; Kajuro Komeda; R Nakano; H Miki; Shinobu Satoh; Hisahiko Sekihara; S Sciacchitano; MA Lesniak; Shin Aizawa; Ryozo Nagai; Satoshi Kimura; Yasuo Akanuma; Simeon I Taylor; Takashi Kadowaki
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Diabetes 2000;49(11):1880-9.
2000: Toshimasa Yamauchi; N Yamauchi; Keisuke Ueki; Takashi Sugiyama; Hironori Waki; Hiroshi Miki; Kazuyuki Tobe; S Matsuda; T Tsushima; Tadashi Yamamoto; Tomoyuki Fujita; Y Taketani; Masashi Fukayama; Satoshi Kimura; Yoshio Yazaki; Ryozo Nagai; Takashi Kadowaki
Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer.
The Journal of biological chemistry 2000;275(43):33937-44.
2000: Takashi Kadowaki; Makoto Watanabe; Akira Okayama; Kayoko Hishida; Hirotsugu Ueshima
Effectiveness of smoking-cessation intervention in all of the smokers at a worksite in Japan.
Industrial health 2000;38(4):396-403.
2000: Ritsuko Yamamoto-Honda; Z Honda; Yasushi Kaburagi; Keisuke Ueki; Satoshi Kimura; Yasuo Akanuma; Takashi Kadowaki
Overexpression of the glycogen targeting (G(M)) subunit of protein phosphatase-1.
Biochemical and biophysical research communications 2000;275(3):859-64.
2000: Takashi Kadowaki
Insights into insulin resistance and type 2 diabetes from knockout mouse models.
The Journal of clinical investigation 2000;106(4):459-65.
2000: Y Takahashi; M Noda; S Tsugane; T Kuzuya; C Ito; Takashi Kadowaki
Prevalence of diabetes estimated by plasma glucose criteria combined with standardized measurement of HbA1c among health checkup participants on Miyako Island, Japan.
Diabetes care 2000;23(8):1092-6.
2000: Keisuke Ueki; Toshimasa Yamauchi; H Tamemoto; Kazuyuki Tobe; Ritsuko Yamamoto-Honda; Yasushi Kaburagi; Yasuo Akanuma; Yoshio Yazaki; Shin Aizawa; Ryozo Nagai; Takashi Kadowaki
Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy.
The Journal of clinical investigation 2000;105(10):1437-45.
2000: Kazuo Hara; Terumasa Okada; Kazuyuki Tobe; Kazuki Yasuda; Yasumichi Mori; Hiroko Kadowaki; Ryoko Hagura; Yasuo Akanuma; Satoshi Kimura; Chikako Ito; Takashi Kadowaki
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes.
Biochemical and biophysical research communications 2000;271(1):212-6.
2000: Naoshi Ogata; Daichi Chikazu; Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; Yoshiaki Azuma; T Ohta; Takashi Kadowaki; Kozo Nakamura; Hiroshi Kawaguchi
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover.
The Journal of clinical investigation 2000;105(7):935-43.
2000: Kazuo Hara; Kazuyuki Tobe; Y Uchigata; M Nakazono; Kazuki Yasuda; Y Terauchi; Y Iwamoto; Yasuo Akanuma; Satoshi Kimura; Takashi Kadowaki
Antibody-mediated insulin resistance treated by cessation of insulin administration.
Internal medicine (Tokyo, Japan) 2000;39(2):143-5.
2000: Hiroo Ueno; E Kondo; Ritsuko Yamamoto-Honda; Kazuyuki Tobe; Tetsuya Nakamoto; Kazuki Sasaki; Kinuko Mitani; A Furusaka; Toshihiro Tanaka; Y Tsujimoto; Takashi Kadowaki; Hisamura Hirai
Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function.
Molecular biology of the cell 2000;11(2):735-46.
2000: Yasuo Terauchi; Naoto Kubota; H Tamemoto; H Sakura; Ryozo Nagai; Yasuo Akanuma; Satoshi Kimura; Takashi Kadowaki
Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.
Diabetes 2000;49(1):82-6.
1999: Takashi Kadowaki
[Molecular pathogenesis of type 2 diabetes mellitus].
Seikagaku. The Journal of Japanese Biochemical Society 1999;71(11):1281-98.
1999: Naoto Kubota; Yasuo Terauchi; H Miki; H Tamemoto; Toshimasa Yamauchi; Kajuro Komeda; Shinobu Satoh; R Nakano; Chiaki Ishii; T Sugiyama; Kazuhiro Eto; Yoshiharu Tsubamoto; Akira Okuno; K Murakami; Hisahiko Sekihara; G Hasegawa; M Naito; Y Toyoshima; S Tanaka; K Shiota; T Kitamura; Tomoyuki Fujita; Osamu Ezaki; Shin Aizawa; Takashi Kadowaki
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.
Molecular cell 1999;4(4):597-609.
1999: Kazuhiro Eto; S Suga; M Wakui; Yoshiharu Tsubamoto; Yasuo Terauchi; J Taka; Shin Aizawa; Mitsuhiko Noda; Satoshi Kimura; Haruo Kasai; Takashi Kadowaki
NADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretion.
The Journal of biological chemistry 1999;274(36):25386-92.
1999: Yoshinori Seko; N Takahashi; H Sabe; Kazuyuki Tobe; Takashi Kadowaki; Ryozo Nagai
Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1999;262(1):290-6.
1999: N Takahashi; Yoshinori Seko; Eisei Noiri; Kazuyuki Tobe; Takashi Kadowaki; H Sabe; Yoshio Yazaki
Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125FAK) in cultured rat cardiac myocytes.
Circulation research 1999;84(10):1194-202.
1999: Shuichi Otabe; Kazuki Yasuda; Yasumichi Mori; K Shimokawa; Hiroko Kadowaki; A Jimi; K Nonaka; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Molecular and histological evaluation of pancreata from patients with a mitochondrial gene mutation associated with impaired insulin secretion.
Biochemical and biophysical research communications 1999;259(1):149-56.
1999: Yoshinori Seko; N Takahashi; Kazuyuki Tobe; Takashi Kadowaki; Yoshio Yazaki
Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1999;259(1):8-14.
1999: Yasumichi Mori; H Kim-Motoyama; Yoshiaki Ito; T Katakura; Kazuki Yasuda; S Ishiyama-Shigemoto; K Yamada; Yasuo Akanuma; Y Ohashi; Satoshi Kimura; Yoshio Yazaki; Takashi Kadowaki
The Gln27Glu beta2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men.
Biochemical and biophysical research communications 1999;258(1):138-40.
1999: Yunzeng Zou; Issei Komuro; Tadashi Yamazaki; Sumiyo Kudoh; Hiroki Uozumi; Takashi Kadowaki; Yoshio Yazaki
Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy.
The Journal of biological chemistry 1999;274(14):9760-70.
1999: Ryuichi Aikawa; Issei Komuro; Tadashi Yamazaki; Yunzeng Zou; Sumiyo Kudoh; W Zhu; Takashi Kadowaki; Yoshio Yazaki
Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes.
Circulation research 1999;84(4):458-66.
1999: Yasushi Kaburagi; Toshimasa Yamauchi; Ritsuko Yamamoto-Honda; Keisuke Ueki; Kazuyuki Tobe; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family.
Endocrine journal 1999;46 Suppl():S25-34.
1999: Takashi Kadowaki
[Insulin-sensitizing agents].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(3):688-94.
1999: Kazuhiro Eto; Takashi Kadowaki
[Role of the NADH shuttle system in glucose-induced insulin secretion].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(3):503-14.
1999: Kazuhiro Eto; Yoshiharu Tsubamoto; Yasuo Terauchi; T Sugiyama; T Kishimoto; Noriko Takahashi; N Yamauchi; Naoto Kubota; S Murayama; T Aizawa; Yasuo Akanuma; Shin Aizawa; Haruo Kasai; Y Yazaki; Takashi Kadowaki
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion.
Science (New York, N.Y.) 1999;283(5404):981-5.
1999: Y Takahashi; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Formation of distinct signalling complexes involving phosphatidylinositol 3-kinase activity with stimulation of epidermal growth factor or insulin-like growth factor-I in human skin fibroblasts.
Journal of cellular physiology 1999;178(1):69-75.
1998: Koji Murakami; Kazuyuki Tobe; Tomohiro Ide; T Mochizuki; M Ohashi; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.
Diabetes 1998;47(12):1841-7.
1998: Yasumichi Mori; H Kim-Motoyama; T Katakura; Kazuki Yasuda; Hiroko Kadowaki; Brock A Beamer; Alan R Shuldiner; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Effect of the Pro12Ala variant of the human peroxisome proliferator-activated receptor gamma 2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men.
Biochemical and biophysical research communications 1998;251(1):195-8.
1998: Sumiyo Kudoh; Issei Komuro; Yukio Hiroi; Yunzeng Zou; Kenji Harada; Takeshi Sugaya; N Takekoshi; Koji Murakami; Takashi Kadowaki; Yoshio Yazaki
Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice.
The Journal of biological chemistry 1998;273(37):24037-43.
1998: T Hayakawa; Mitsuhiko Noda; Kazuki Yasuda; H Yorifuji; Shun'ichiro Taniguchi; Ichitomo Miwa; H Sakura; Yasuo Terauchi; J Hayashi; Geoffrey W G Sharp; Y Kanazawa; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9.
The Journal of biological chemistry 1998;273(32):20300-7.
1998: Toshimasa Yamauchi; Yasushi Kaburagi; Keisuke Ueki; Y Tsuji; G R Stark; I M Kerr; T Tsushima; Yasuo Akanuma; Issei Komuro; Kazuyuki Tobe; Yoshio Yazaki; Takashi Kadowaki
Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.
The Journal of biological chemistry 1998;273(25):15719-26.
1998: Yoshinori Seko; N Takahashi; Kazuyuki Tobe; K Ueki; Takashi Kadowaki; Yoshio Yazaki
Vascular endothelial growth factor (VEGF) activates Raf-1, mitogen-activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes.
Journal of cellular physiology 1998;175(3):239-46.
1998: H Abe; Nobuhiro Yamada; K Kamata; T Kuwaki; M Shimada; Jun-ichi Osuga; Futoshi Shionoiri; Naoya Yahagi; Takashi Kadowaki; H Tamemoto; Shun Ishibashi; Yoshio Yazaki; M Makuuchi
Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
The Journal of clinical investigation 1998;101(8):1784-8.
1998: Toshimasa Yamauchi; Keisuke Ueki; Kazuyuki Tobe; H Tamemoto; Nobuo Sekine; M Wada; M Honjo; Michio Takahashi; Tokiharu Takahashi; Hisamura Hirai; T Tsushima; Yasuo Akanuma; Tomoyuki Fujita; Issei Komuro; Yoshio Yazaki; Takashi Kadowaki
Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation and gene expression.
Endocrine journal 1998;45 Suppl():S27-31.
1998: Akira Okuno; H Tamemoto; Kazuyuki Tobe; Keisuke Ueki; Y Mori; K Iwamoto; K Umesono; Yasuo Akanuma; Toshihiko Fujiwara; H Horikoshi; Yoshio Yazaki; Takashi Kadowaki
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
The Journal of clinical investigation 1998;101(6):1354-61.
1998: Keisuke Ueki; Ritsuko Yamamoto-Honda; Yasushi Kaburagi; Toshimasa Yamauchi; Kazuyuki Tobe; Boudewijn M T Burgering; Paul J Coffer; Issei Komuro; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis.
The Journal of biological chemistry 1998;273(9):5315-22.
1998: Yunzeng Zou; Issei Komuro; Tadashi Yamazaki; Sumiyo Kudoh; Ryuichi Aikawa; W Zhu; Ichiro Shiojima; Yukio Hiroi; Kazuyuki Tobe; Takashi Kadowaki; Yoshio Yazaki
Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts.
Circulation research 1998;82(3):337-45.
1998: Yasuhiro Takahashi; Hiroko Kadowaki; A Ando; J D Quin; A C MacCuish; Yoshio Yazaki; Yasuo Akanuma; Takashi Kadowaki
Two aberrant splicings caused by mutations in the insulin receptor gene in cultured lymphocytes from a patient with Rabson-Mendenhall's syndrome.
The Journal of clinical investigation 1998;101(3):588-94.
1998: Yasuo Terauchi; Takashi Kadowaki
[Glucokinase knockout mice].
Nihon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():746-52.
1998: H Tamemoto; T Izumi; Yasushi Kaburagi; Yasuo Terauchi; Kazuyuki Tobe; Takashi Kadowaki
[IRS-1 knockout mouse].
Nihon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():738-45.
1998: Kazuki Yasuda; Takashi Kadowaki
[MODY (maturity-on-set diabetes of the young)].
Nihon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():566-72.
1998: Kazuhiro Eto; Takashi Kadowaki
[Diabetes caused by glucokinase mutation].
Nihon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():554-65.
1997: Toshimasa Yamauchi; Keisuke Ueki; Kazuyuki Tobe; H Tamemoto; Nobuo Sekine; M Wada; M Honjo; Michio Takahashi; Tokiharu Takahashi; Hisamura Hirai; T Tushima; Yasuo Akanuma; Tomoyuki Fujita; Issei Komuro; Yoshio Yazaki; Takashi Kadowaki
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone.
Nature 1997;390(6655):91-6.
1997: Yoshinori Seko; N Takahashi; Kazuyuki Tobe; Takashi Kadowaki; Yoshio Yazaki
Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 mitogen-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1997;239(3):840-4.
1997: Yasushi Kaburagi; Shinobu Satoh; H Tamemoto; Ritsuko Yamamoto-Honda; Kazuyuki Tobe; K Veki; Toshimasa Yamauchi; E Kono-Sugita; Hisahiko Sekihara; Shin Aizawa; S W Cushman; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes.
The Journal of biological chemistry 1997;272(41):25839-44.
1997: Kazuki Yasuda; Yasuo Akanuma; Takashi Kadowaki
[Beta 3-adrenergic receptors].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():468-72.
1997: Kazuhiro Eto; Takashi Kadowaki
[Glucokinase gene and its dual promoter regions].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():414-22.
1997: Kazuyuki Tobe; Takashi Kadowaki
[Defects in insulin's signalling process and diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():328-42.
1997: Takashi Kadowaki; Kazuki Yasuda; K Etou; Yasuhiro Takahashi; Yasuo Terauchi
[Molecular genetics of NIDDM].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():314-9.
1997: H Tamemoto; Kazuyuki Tobe; Toshimasa Yamauchi; Yasuo Terauchi; Yasushi Kaburagi; Takashi Kadowaki
Insulin resistance syndrome in mice deficient in insulin receptor substrate-1.
Annals of the New York Academy of Sciences 1997;827():85-93.
1997: Hiroko Kadowaki; Yasuhiro Takahashi; A Ando; K Momomura; Yasushi Kaburagi; J D Quin; A C MacCuish; N Koda; Yasushi Fukushima; Simeon I Taylor; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
Four mutant alleles of the insulin receptor gene associated with genetic syndromes of extreme insulin resistance.
Biochemical and biophysical research communications 1997;237(3):516-20.
1997: N Takahashi; Takashi Kadowaki; Yoshio Yazaki; Yasushi Miyashita; Haruo Kasai
Multiple exocytotic pathways in pancreatic beta cells.
The Journal of cell biology 1997;138(1):55-64.
1997: H Kim-Motoyama; Kazuki Yasuda; Tokio Yamaguchi; Nobuhiro Yamada; T Katakura; Alan R Shuldiner; Yasuo Akanuma; Y Ohashi; Yoshio Yazaki; Takashi Kadowaki
A mutation of the beta 3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride.
Diabetologia 1997;40(4):469-72.
1997: Yasuhiro Takahashi; Hiroko Kadowaki; K Momomura; Yasushi Fukushima; T Orban; T Okai; Yuji Taketani; Yasuo Akanuma; Yoshio Yazaki; Takashi Kadowaki
A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism.
Diabetologia 1997;40(4):412-20.
1997: Yasuhiro Takahashi; Takashi Kadowaki
[Assessment of insulin resistance by minimal model analysis].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl 1():252-5.
1997: Yasuo Terauchi; K Iwamoto; H Tamemoto; Kajuro Komeda; Chiaki Ishii; Y Kanazawa; N Asanuma; T Aizawa; Yasuo Akanuma; Kazuki Yasuda; Tatsuhiko Kodama; Kazuyuki Tobe; Yoshio Yazaki; Takashi Kadowaki
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.
The Journal of clinical investigation 1997;99(5):861-6.
1997: Hirotsugu Ueshima; Takashi Kadowaki
[Alcohol drinking habit and mortality].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():517-21.
1997: Yasuhiro Takahashi; Kazuyuki Tobe; Hiroko Kadowaki; D Katsumata; Yasushi Fukushima; Yoshio Yazaki; Yasuo Akanuma; Takashi Kadowaki
Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts.
Endocrinology 1997;138(2):741-50.
1996: Toru Aizawa; N Asanuma; Yasuo Terauchi; N Suzuki; Mitsuhisa Komatsu; N Itoh; T Nakabayashi; H Hidaka; H Ohnota; K Yamauchi; Kazuki Yasuda; Y Yazaki; Takashi Kadowaki; Kiyoshi Hashizume
Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene.
Biochemical and biophysical research communications 1996;229(2):460-5.
1996: Ritsuko Yamamoto-Honda; Zen-ichiro Honda; Keisuke Ueki; Kazuyuki Tobe; Yasushi Kaburagi; Yasuhiro Takahashi; H Tamemoto; T Suzuki; K Itoh; Yasuo Akanuma; Y Yazaki; Takashi Kadowaki
Mutant of insulin receptor substrate-1 incapable of activating phosphatidylinositol 3-kinase did not mediate insulin-stimulated maturation of Xenopus laevis oocytes.
The Journal of biological chemistry 1996;271(45):28677-81.
1996: Takashi Kadowaki; Kazuyuki Tobe; R Honda-Yamamoto; H Tamemoto; Yasushi Kaburagi; K Momomura; Keisuke Ueki; Yasuhiro Takahashi; Toshimasa Yamauchi; Yasuo Akanuma; Y Yazaki
Signal transduction mechanism of insulin and insulin-like growth factor-1.
Endocrine journal 1996;43 Suppl():S33-41.
1996: Yoshinori Seko; Kazuyuki Tobe; N Takahashi; Yasushi Kaburagi; Takashi Kadowaki; Y Yazaki
Hypoxia and hypoxia/reoxygenation activate Src family tyrosine kinases and p21ras in cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1996;226(2):530-5.
1996: Takashi Kadowaki; H Tamemoto; Kazuyuki Tobe; Yasuo Terauchi; Keisuke Ueki; Yasushi Kaburagi; Toshimasa Yamauchi; S Satoh; Hisahiko Sekihara; Shin Aizawa; Y Yazaki
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 and identification of insulin receptor substrate-2.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(9 Suppl 6):S103-8.
1996: Kazuyuki Tobe; H Sabe; T Yamamoto; Toshimasa Yamauchi; S Asai; Yasushi Kaburagi; H Tamemoto; Keisuke Ueki; H Kimura; Yasuo Akanuma; Y Yazaki; H Hanafusa; Takashi Kadowaki
Csk enhances insulin-stimulated dephosphorylation of focal adhesion proteins.
Molecular and cellular biology 1996;16(9):4765-72.
1996: T Tanaka; Mineo Kurokawa; Keisuke Ueki; K Tanaka; Yoichi Imai; Kinuko Mitani; K Okazaki; N Sagata; Y Yazaki; Y Shibata; Takashi Kadowaki; H Hirai
The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability.
Molecular and cellular biology 1996;16(7):3967-79.
1996: Toshimasa Yamauchi; Kazuyuki Tobe; H Tamemoto; Keisuke Ueki; Yasushi Kaburagi; Ritsuko Yamamoto-Honda; Yasuhiro Takahashi; F Yoshizawa; Shin Aizawa; Yasuo Akanuma; N Sonenberg; Y Yazaki; Takashi Kadowaki
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
Molecular and cellular biology 1996;16(6):3074-84.
1996: Yoshinori Seko; Kazuyuki Tobe; Keisuke Ueki; Takashi Kadowaki; Y Yazaki
Hypoxia and hypoxia/reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes.
Circulation research 1996;78(1):82-90.
1995: A Muraoka; M Hashiramoto; A E Clark; L C Edwards; H Sakura; Takashi Kadowaki; G D Holman; Masato Kasuga
Analysis of the structural features of the C-terminus of GLUT1 that are required for transport catalytic activity.
The Biochemical journal 1995;311 ( Pt 2)():699-704.
1995: Yasushi Kaburagi; Ritsuko Yamamoto-Honda; Kazuyuki Tobe; Keisuke Ueki; M Yachi; Yasuo Akanuma; R M Stephens; D Kaplan; Y Yazaki; Takashi Kadowaki
The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and Shc.
Endocrinology 1995;136(8):3437-43.
1995: Issei Komuro; Tadashi Yamazaki; Y Katoh; Kazuyuki Tobe; Takashi Kadowaki; Ryozo Nagai; Y Yazaki
Protein kinase cascade activated by mechanical stress in cardiocytes: possible involvement of angiotensin II.
European heart journal 1995;16 Suppl C():8-11.
1995: Kazuyuki Tobe; H Tamemoto; Toshimasa Yamauchi; Shin Aizawa; Y Yazaki; Takashi Kadowaki
Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.
The Journal of biological chemistry 1995;270(11):5698-701.
1995: N Morino; Toshihide Mimura; K Hamasaki; Kazuyuki Tobe; Keisuke Ueki; K Kikuchi; K Takehara; Takashi Kadowaki; Y Yazaki; Yoshihisa Nojima
Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2.
The Journal of biological chemistry 1995;270(1):269-73.
1995: Takashi Kadowaki; Yasumichi Mori; Shuichi Otabe; H Sakura; Kazuki Yasuda; Yasuo Akanuma; Ryoko Hagura; Hiroko Kadowaki; Yoshio Yazaki
A subtype of diabetes mellitus associated with a mutation in the mitochondrial gene.
Muscle & nerve. Supplement 1995;(3):S137-41.
1995: Takashi Kadowaki; H Sakura; S Otabe; Kazuki Yasuda; Hiroko Kadowaki; Yasumichi Mori; Ryoko Hagura; Yasuo Akanuma; Y Yazaki
A subtype of diabetes mellitus associated with a mutation in the mitochondrial gene.
Muscle & nerve. Supplement 1995;3():S137-41.
1994: Takuya Awata; C Matsumoto; K Momomura; Yasuhiro Takahashi; M Odawara; M Kasuga; Takashi Kadowaki; Y Iwamoto
A 3-basepair in-frame deletion (delta Leu999) in exon 17 of the insulin receptor gene in a family with insulin resistance.
The Journal of clinical endocrinology and metabolism 1994;79(6):1840-4.
1994: H Tamemoto; Takashi Kadowaki; Kazuyuki Tobe; T Yagi; H Sakura; T Hayakawa; Yasuo Terauchi; Keisuke Ueki; Yasushi Kaburagi; S Satoh
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.
Nature 1994;372(6502):182-6.
1994: Takashi Kadowaki
[Mutations in the mitochondrial gene in patients with NIDDM].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2708-14.
1994: Kazuyuki Tobe; Keisuke Ueki; H Tamemoto; Yasushi Kaburagi; R Honda; Takashi Kadowaki
[The role of phosphorylation cascade in insulin action].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2673-85.
1994: Takashi Kadowaki
[Classification of mutations in the insulin receptor gene].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2653-7.
1994: Hiroko Kadowaki; Takashi Kadowaki
[HAIR-AN syndrome].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(10):2648-52.
1994: Masato Kasuga; Takashi Kadowaki
Insulin receptor disorders in Japan.
Diabetes research and clinical practice 1994;24 Suppl():S145-51.
1994: Takashi Kadowaki; H Yoshinaga
Risk factors for the development of non-insulin-dependent diabetes mellitus (NIDDM) in Japan.
Diabetes research and clinical practice 1994;24 Suppl():S123-7.
1994: K Shimokawa; H Sakura; S Otabe; Kazuhiro Eto; Hiroko Kadowaki; Ryoko Hagura; Y Yazaki; Yasuo Akanuma; Takashi Kadowaki
Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1994;79(3):883-6.
1994: K Shimokawa; Hiroko Kadowaki; H Sakura; S Otabe; Ryoko Hagura; K Kosaka; Y Yazaki; Yasuo Akanuma; Takashi Kadowaki
Molecular scanning of the glycogen synthase and insulin receptor substrate-1 genes in Japanese subjects with non-insulin-dependent diabetes mellitus.
Biochemical and biophysical research communications 1994;202(1):463-9.
1994: Keisuke Ueki; S Matsuda; Kazuyuki Tobe; Y Gotoh; H Tamemoto; M Yachi; Yasuo Akanuma; Y Yazaki; E Nishida; Takashi Kadowaki
Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation.
The Journal of biological chemistry 1994;269(22):15756-61.
1994: K Eto; H Sakura; Kazuki Yasuda; T Hayakawa; Eiji Kawasaki; R Moriuchi; S Nagataki; Y Yazaki; Takashi Kadowaki
Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet.
Biochemical and biophysical research communications 1994;198(3):990-8.
1994: Kazuyoshi Yonezawa; A Ando; Yasushi Kaburagi; Ritsuko Yamamoto-Honda; T Kitamura; Kenta Hara; M Nakafuku; Yoshinori Okabayashi; Takashi Kadowaki; Y Kaziro
Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.
The Journal of biological chemistry 1994;269(6):4634-40.
1994: Yoshikazu Tamori; M Hashiramoto; A E Clark; Hiroyuki Mori; A Muraoka; Takashi Kadowaki; G D Holman; Masato Kasuga
Substitution at Pro385 of GLUT1 perturbs the glucose transport function by reducing conformational flexibility.
The Journal of biological chemistry 1994;269(4):2982-6.
1993: Yasushi Kaburagi; K Momomura; Ritsuko Yamamoto-Honda; Kazuyuki Tobe; Y Tamori; H Sakura; Yasuo Akanuma; Y Yazaki; Takashi Kadowaki
Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor.
The Journal of biological chemistry 1993;268(22):16610-22.
1993: Ritsuko Yamamoto-Honda; Takashi Kadowaki; K Momomura; Kazuyuki Tobe; Y Tamori; Yoshikazu Shibasaki; Y Mori; Yasushi Kaburagi; O Koshio; Yasuo Akanuma
Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin.
The Journal of biological chemistry 1993;268(22):16859-65.
1993: Kazuhiro Eto; H Sakura; K Shimokawa; Hiroko Kadowaki; Ryoko Hagura; Yasuo Akanuma; Y Yazaki; Takashi Kadowaki
Sequence variations of the glucokinase gene in Japanese subjects with NIDDM.
Diabetes 1993;42(8):1133-7.
1993: Tadashi Yamazaki; Kazuyuki Tobe; E Hoh; Koji Maemura; T Kaida; Issei Komuro; H Tamemoto; Takashi Kadowaki; Ryozo Nagai; Y Yazaki
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.
The Journal of biological chemistry 1993;268(16):12069-76.
1993: Y Yazaki; Issei Komuro; Tadashi Yamazaki; Kazuyuki Tobe; Koji Maemura; Takashi Kadowaki; Ryozo Nagai
Role of protein kinase system in the signal transduction of stretch-mediated protooncogene expression and hypertrophy of cardiac myocytes.
Molecular and cellular biochemistry 1993;119(1-2):11-6.
1992: H Sakura; Kazuhiro Eto; Hiroko Kadowaki; K Simokawa; H Ueno; N Koda; Y Fukushima; Yasuo Akanuma; Y Yazaki; Takashi Kadowaki
Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1992;75(6):1571-3.
1992: Kazuyuki Tobe; Takashi Kadowaki; K Hara; Y Gotoh; H Kosako; S Matsuda; H Tamemoto; Keisuke Ueki; Yasuo Akanuma; E Nishida
Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection.
The Journal of biological chemistry 1992;267(29):21089-97.
1992: H Tamemoto; Takashi Kadowaki; Kazuyuki Tobe; K Ueki; T Izumi; Y Chatani; Michiaki Kohno; M Kasuga; Y Yazaki; Yasuo Akanuma
Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.
The Journal of biological chemistry 1992;267(28):20293-7.
1992: M Hashiramoto; Takashi Kadowaki; A E Clark; A Muraoka; K Momomura; H Sakura; Kazuyuki Tobe; Yasuo Akanuma; Y Yazaki; G D Holman
Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding.
The Journal of biological chemistry 1992;267(25):17502-7.
1992: Y Chatani; E Tanaka; Kazuyuki Tobe; A Hattori; M Sato; H Tamemoto; N Nishizawa; H Nomoto; T Takeya; Takashi Kadowaki
Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases/microtubule-associated protein 2 kinases.
The Journal of biological chemistry 1992;267(14):9911-6.
1992: M Kishimoto; H Sakura; K Hayashi; Yasuo Akanuma; Y Yazaki; M Kasuga; Takashi Kadowaki
Detection of mutations in the human insulin gene by single strand conformation polymorphisms.
The Journal of clinical endocrinology and metabolism 1992;74(5):1027-31.
1992: T Inaba; Nobuhiro Yamada; Takanari Gotoda; Hitoshi Shimano; Mitsuo Shimada; K Momomura; Takashi Kadowaki; K Motoyoshi; T Tsukada; N Morisaki
Expression of M-CSF receptor encoded by c-fms on smooth muscle cells derived from arteriosclerotic lesion.
The Journal of biological chemistry 1992;267(8):5693-9.
1991: Kazuyuki Tobe; Takashi Kadowaki; H Tamemoto; Keisuke Ueki; K Hara; O Koshio; K Momomura; Y Gotoh; E Nishida; Yasuo Akanuma
Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.
The Journal of biological chemistry 1991;266(36):24793-803.
1991: Takashi Izumi; H Tamemoto; M Nagao; Takashi Kadowaki; F Takaku; M Kasuga
Insulin and platelet-derived growth factor stimulate phosphorylation of the c-raf product at serine and threonine residues in intact cells.
The Journal of biological chemistry 1991;266(12):7933-9.
1991: M Kawakami; E Nishida; Kazuyuki Tobe; M Hoshi; Takashi Kadowaki; M Kasuga; H Sakai
Activation of MAP kinase and enhanced phosphorylation of the 350-kDa protein by mitogenic stimuli in quiescent Balb/c 3T3 cells.
Experimental cell research 1991;193(1):120-6.
1991: Takashi Kadowaki; M Kasuga
[Mutations in the insulin receptor gene in patients with genetic forms of insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 1991;49 Suppl():721-30.
1990: Ritsuko Yamamoto-Honda; O Koshio; Kazuyuki Tobe; Yoshikazu Shibasaki; K Momomura; M Odawara; Takashi Kadowaki; F Takaku; Yasuo Akanuma; M Kasuga
Phosphorylation state and biological function of a mutant human insulin receptor Val996.
The Journal of biological chemistry 1990;265(25):14777-83.
1990: M Kasuga; Takashi Izumi; Kazuyuki Tobe; T Shiba; K Momomura; Y Tashiro-Hashimoto; Takashi Kadowaki
Substrates for insulin-receptor kinase.
Diabetes care 1990;13(3):317-26.
1989: M Odawara; Takashi Kadowaki; R Yamamoto; Yoshikazu Shibasaki; Kazuyuki Tobe; D Accili; Charles L Bevins; Y Mikami; N Matsuura; Yasuo Akanuma
Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor.
Science (New York, N.Y.) 1989;245(4913):66-8.
1988: M Kasuga; Takashi Izumi; Kazuyuki Tobe; Takashi Kadowaki; K Momomura; S Takayama-Hasumi; O Koshio; Y Tashiro-Hashimoto; Yasuo Akanuma; F Takaku
Role of the insulin receptor kinase activity in insulin action.
Nihon Naibunpi Gakkai zasshi 1988;64(12):1243-9.
1988: E Nishida; Kazuyuki Tobe; Takashi Kadowaki; M Kasuga; C Sato; H Sakai
Stimulation of the phosphorylation of cytoskeletal 350-kDa and 300-kDa proteins by insulin-like growth factor-I, platelet-derived growth factor and phorbol ester in rat 3Y1 cells.
Cell structure and function 1988;13(5):417-23.
1988: Yoshihiko Miyata; M Hoshi; S Koyasu; Takashi Kadowaki; M Kasuga; I Yahara; E Nishida; H Sakai
Rapid stimulation of fluid-phase endocytosis and exocytosis by insulin, insulin-like growth factor-I, and epidermal growth factor in KB cells.
Experimental cell research 1988;178(1):73-83.
1987: E Nishida; M Hoshi; Yoshihiko Miyata; H Sakai; Takashi Kadowaki; M Kasuga; Shinobu Saijo; H Ogawara; T Akiyama
Tyrosine phosphorylation by the epidermal growth factor receptor kinase induces functional alterations in microtubule-associated protein 2.
The Journal of biological chemistry 1987;262(33):16200-4.