William Kaelin

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Chemicals & Drugs

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Zhang Qing; Gu Jinming; Li Lianjie; Liu Jiayun; Luo Biao; Cheung Hiu-Wing; Boehm Jesse S; Ni Min; Geisen Christoph; Root David E; Polyak Kornelia; Brown Myles; Richardson Andrea L; Hahn William C; Kaelin William G; Bommi-Reddy Archana
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.
Minamishima Yoji Andrew; Moslehi Javid; Padera Robert F; Bronson Roderick T; Liao Ronglih; Kaelin William G
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
Kaelin William G
SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling.

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All Publications

2009: Zhang Qing; Gu Jinming; Li Lianjie; Liu Jiayun; Luo Biao; Cheung Hiu-Wing; Boehm Jesse S; Ni Min; Geisen Christoph; Root David E; Polyak Kornelia; Brown Myles; Richardson Andrea L; Hahn William C; Kaelin William G; Bommi-Reddy Archana
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.
Cancer cell 2009;16(5):413-24.
2009: Minamishima Yoji Andrew; Moslehi Javid; Padera Robert F; Bronson Roderick T; Liao Ronglih; Kaelin William G
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
Molecular and cellular biology 2009;29(21):5729-41.
2009: Kaelin William G
SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling.
Cancer cell 2009;16(3):180-2.
2009: Kim William Y; Perera Samanthi; Zhou Bing; Carretero Julian; Yeh Jen Jen; Heathcote Samuel A; Jackson Autumn L; Nikolinakos Petros; Ospina Beatriz; Naumov George; Brandstetter Kathleyn A; Weigman Victor J; Zaghlul Sara; Hayes D Neil; Padera Robert F; Heymach John V; Kung Andrew L; Sharpless Norman E; Kaelin William G; Wong Kwok-Kin
HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.
The Journal of clinical investigation 2009;119(8):2160-70.
2009: Beroukhim Rameen; Brunet Jean-Philippe; Di Napoli Arianna; Mertz Kirsten D; Seeley Apryle; Pires Maira M; Linhart David; Worrell Robert A; Moch Holger; Rubin Mark A; Sellers William R; Meyerson Matthew; Linehan W Marston; Kaelin William G; Signoretti Sabina
Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney.
Cancer research 2009;69(11):4674-81.
2009: Atkins Michael B; Bukowski Ronald M; Escudier Bernard J; Figlin Robert A; Hudes Gary H; Kaelin William G; Linehan W Marston; McDermott David F; Mier James W; Pedrosa Ivan; Rini Brian I; Signoretti Sabina; Sosman Jeffrey A; Teh Bin Tean; Wood Christopher G; Zurita Amado J; King Laura
Innovations and challenges in renal cancer: summary statement from the Third Cambridge Conference.
Cancer 2009;115(10 Suppl):2247-51.
2009: Kaelin William G
Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein.
Cancer 2009;115(10 Suppl):2262-72.
2008: Kaelin William G
Kidney cancer: now available in a new flavor.
Cancer cell 2008;14(6):423-4.
2008: Young Arthur P; Kaelin William G
Senescence triggered by the loss of the VHL tumor suppressor.
Cell cycle (Georgetown, Tex.) 2008;7(12):1709-12.
2008: Kaelin William G; Ratcliffe Peter J
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Molecular cell 2008;30(4):393-402.
2008: Schlisio Susanne; Kenchappa Rajappa S; Vredeveld Liesbeth C W; George Rani E; Stewart Rodney; Greulich Heidi; Shahriari Kristina; Nguyen Nguyen V; Pigny Pascal; Dahia Patricia L; Pomeroy Scott L; Maris John M; Look A Thomas; Meyerson Matthew; Peeper Daniel S; Carter Bruce D; Kaelin William G
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
Genes & development 2008;22(7):884-93.
2008: Young Arthur P; Schlisio Susanne; Minamishima Yoji Andrew; Zhang Qing; Li Lianjie; Grisanzio Chiara; Signoretti Sabina; Kaelin William G
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
Nature cell biology 2008;10(3):361-9.
2008: Minamishima Yoji Andrew; Moslehi Javid; Bardeesy Nabeel; Cullen Darragh; Bronson Roderick T; Kaelin William G
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.
Blood 2008;111(6):3236-44.
2007: Kaelin William G; Sawyers Charles L; Mihich Enrico
Nineteenth Annual Pezcoller Symposium: hypothesis-driven clinical investigation in cancer.
Cancer research 2007;67(23):11102-5.
2007: Yang Haifeng; Minamishima Yoji Andrew; Yan Qin; Schlisio Susanne; Ebert Benjamin L; Zhang Xiaoping; Zhang Liang; Kim William Y; Olumi Aria F; Kaelin William G
pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.
Molecular cell 2007;28(1):15-27.
2007: Li Lianjie; Zhang Liang; Zhang Xiaoping; Yan Qin; Minamishima Yoji Andrew; Olumi Aria F; Mao Mao; Bartz Steven; Kaelin William G
Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.
Molecular and cellular biology 2007;27(15):5381-92.
2007: Klose Robert J; Yan Qin; Tothova Zuzana; Yamane Kenichi; Erdjument-Bromage Hediye; Tempst Paul; Gilliland D Gary; Zhang Yi; Kaelin William G
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
Cell 2007;128(5):889-900.
2007: Yan Qin; Bartz Steven; Mao Mao; Li Lianjie; Kaelin William G
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.
Molecular and cellular biology 2007;27(6):2092-102.
2007: Binné Ulrich K; Classon Marie K; Dick Frederick A; Wei Wenyi; Rape Michael; Kaelin William G; Näär Anders M; Dyson Nicholas J
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.
Nature cell biology 2007;9(2):225-32.
2007: Kaelin William G
The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(2 Pt 2):680s-684s.
2007: Atkins Michael B; Ernstoff Marc S; Figlin Robert A; Flaherty Keith T; George Daniel J; Kaelin William G; Kwon Eugene D; Libermann Towia A; Linehan W Marston; McDermott David F; Ochoa Augusto C; Pantuck Allan J; Rini Brian I; Rosen Mark A; Sosman Jeffrey A; Sukhatme Vikas P; Vieweg Johannes W; Wood Christopher G; King Laura
Innovations and challenges in renal cell carcinoma: summary statement from the Second Cambridge Conference.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(2 Pt 2):667s-670s.
2007: Kaelin William G
Von Hippel-Lindau disease.
Annual review of pathology 2007;2():145-73.
2007: Kaelin William G
The von hippel-lindau tumor suppressor protein: an update.
Methods in enzymology 2007;435():371-83.
2006: Kim William Y; Kaelin William G
Molecular pathways in renal cell carcinoma--rationale for targeted treatment.
Seminars in oncology 2006;33(5):588-95.
2006: Kim William Y; Safran Michal; Buckley Marshall R M; Ebert Benjamin L; Glickman Jonathan; Bosenberg Marcus; Regan Meredith; Kaelin William G
Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.
The EMBO journal 2006;25(19):4650-62.
2006: Kaelin William G
Cell biology: divining cancer cell weaknesses.
Nature 2006;441(7089):32-4.
2006: Nakamura Eijiro; Abreu-e-Lima Paula; Awakura Yasuo; Inoue Takahiro; Kamoto Toshiyuki; Ogawa Osamu; Kotani Hirokazu; Manabe Toshiaki; Zhang Guo-Jun; Kondo Keiichi; Nosé Vania; Kaelin William G
Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein.
The American journal of pathology 2006;168(2):574-84.
2006: Safran Michal; Kim William Y; O'Connell Fionnuala; Flippin Lee; Günzler Volkmar; Horner James W; Depinho Ronald A; Kaelin William G
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):105-10.
2006: Nakamura Eijiro; Kaelin William G
Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma.
Endocrine pathology 2006;17(2):97-106.
2005: Kaelin William G
The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing.
Biochemical and biophysical research communications 2005;338(1):627-38.
2005: Kaelin William G
The concept of synthetic lethality in the context of anticancer therapy.
Nature reviews. Cancer 2005;5(9):689-98.
2005: Lee Sungwoo; Nakamura Eijiro; Yang Haifeng; Wei Wenyi; Linggi Michelle S; Sajan Mini P; Farese Robert V; Freeman Robert S; Carter Bruce D; Kaelin William G; Schlisio Susanne
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
Cancer cell 2005;8(2):155-67.
2005: Wei Wenyi; Jin Jianping; Schlisio Susanne; Harper J Wade; Kaelin William G
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.
Cancer cell 2005;8(1):25-33.
2005: Kaelin William G
ROS: really involved in oxygen sensing.
Cell metabolism 2005;1(6):357-8.
2005: Benevolenskaya Elizaveta V; Murray Heather L; Branton Philip; Young Richard A; Kaelin William G
Binding of pRB to the PHD protein RBP2 promotes cellular differentiation.
Molecular cell 2005;18(6):623-35.
2005: Kaelin W G
The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing.
Cold Spring Harbor symposia on quantitative biology 2005;70():159-66.
2005: Zhang Guo-Jun; Kaelin William G
Bioluminescent imaging of ubiquitin ligase activity: measuring Cdk2 activity in vivo through changes in p27 turnover.
Methods in enzymology 2005;399():530-49.
2005: Kaelin William G
Proline hydroxylation and gene expression.
Annual review of biochemistry 2005;74():115-28.
2004: Kim William Y; Kaelin William G
Role of VHL gene mutation in human cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(24):4991-5004.
2004: Brugarolas James; Lei Kui; Hurley Rebecca L; Manning Brendan D; Reiling Jan H; Hafen Ernst; Witters Lee A; Ellisen Leif W; Kaelin William G
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.
Genes & development 2004;18(23):2893-904.
2004: Olenyuk Bogdan Z; Zhang Guo-Jun; Klco Jeffery M; Nickols Nicholas G; Kaelin William G; Dervan Peter B
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16768-73.
2004: Kaelin William G
The von Hippel-Lindau tumor suppressor gene and kidney cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 2):6290S-5S.
2004: Atkins Michael B; Avigan David E; Bukowski Ronald M; Childs Richard W; Dutcher Janice P; Eisen Tim G; Figlin Robert A; Finke James H; Flanigan Robert C; George Daniel J; Goldberg S Nahum; Gordon Michael S; Iliopoulos Othon; Kaelin William G; Linehan W Marston; Lipton Allan; Motzer Robert J; Novick Andrew C; Stadler Walter M; Teh Bin Tean; Yang James C; King Laura
Innovations and challenges in renal cancer: consensus statement from the first international conference.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 2):6277S-81S.
2004: Brugarolas James; Kaelin William G
Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes.
Cancer cell 2004;6(1):7-10.
2004: Zhang Guo-Jun; Safran Michal; Wei Wenyi; Sorensen Erik; Lassota Peter; Zhelev Nikolai; Neuberg Donna S; Shapiro Geoffrey; Kaelin William G
Bioluminescent imaging of Cdk2 inhibition in vivo.
Nature medicine 2004;10(6):643-8.
2004: Stickle Natalie H; Chung Jacky; Klco Jeffery M; Hill Richard P; Kaelin William G; Ohh Michael
pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development.
Molecular and cellular biology 2004;24(8):3251-61.
2004: Kaelin William G
Gleevec: prototype or outlier?
Science's STKE : signal transduction knowledge environment 2004;2004(225):pe12.
2004: Wei Wenyi; Ayad Nagi G; Wan Yong; Zhang Guo-Jun; Kirschner Marc W; Kaelin William G
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.
Nature 2004;428(6979):194-8.
2004: Yang Haifeng; Ivan Mircea; Min Jung-Hyun; Kim William Y; Kaelin William G
Analysis of von Hippel-Lindau hereditary cancer syndrome: implications of oxygen sensing.
Methods in enzymology 2004;381():320-35.
2003: Kondo Keiichi; Kim William Y; Lechpammer Mirna; Kaelin William G
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
PLoS biology 2003;1(3):E83.
2003: Kaelin William G
The von Hippel-Lindau gene, kidney cancer, and oxygen sensing.
Journal of the American Society of Nephrology : JASN 2003;14(11):2703-11.
2003: Safran Michal; Kim William Y; Kung Andrew L; Horner James W; DePinho Ron A; Kaelin William G
Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination.
Molecular imaging : official journal of the Society for Molecular Imaging 2003;2(4):297-302.
2003: Brugarolas James B; Vazquez Francisca; Reddy Archana; Sellers William R; Kaelin William G
TSC2 regulates VEGF through mTOR-dependent and -independent pathways.
Cancer cell 2003;4(2):147-58.
2003: Kaelin William G
E2F1 as a target: promoter-driven suicide and small molecule modulators.
Cancer biology & therapy 2003;2(4 Suppl 1):S48-54.
2003: George Daniel J; Kaelin William G
The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer.
The New England journal of medicine 2003;349(5):419-21.
2003: Irwin Meredith S; Kondo Keiichi; Marin Maria Carmen; Cheng Lynn S; Hahn William C; Kaelin William G
Chemosensitivity linked to p73 function.
Cancer cell 2003;3(4):403-10.
2003: Jiang Yide; Zhang Wen; Kondo Keichii; Klco Jeffery M; St Martin Thia B; Dufault Michael R; Madden Stephen L; Kaelin William G; Nacht Mariana
Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways.
Molecular cancer research : MCR 2003;1(6):453-62.
2003: Safran Michal; Kaelin William G
HIF hydroxylation and the mammalian oxygen-sensing pathway.
The Journal of clinical investigation 2003;111(6):779-83.
2003: Kim William; Kaelin William G
The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer.
Current opinion in genetics & development 2003;13(1):55-60.
2003: Ohh Michael; Kaelin William G
VHL and kidney cancer.
Methods in molecular biology (Clifton, N.J.) 2003;222():167-83.
2002: Serebriiskii Ilya G; Mitina Olga; Pugacheva Elena N; Benevolenskaya Elizaveta; Kotova Elena; Toby Garabet G; Khazak Vladimir; Kaelin William G; Chernoff Jonathan; Golemis Erica A
Detection of peptides, proteins, and drugs that selectively interact with protein targets.
Genome research 2002;12(11):1785-91.
2002: Ivan Mircea; Haberberger Thomas; Gervasi David C; Michelson Kristen S; Günzler Volkmar; Kondo Keiichi; Yang Haifeng; Sorokina Irina; Conaway Ronald C; Conaway Joan W; Kaelin William G
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13459-64.
2002: Kaelin William G
Molecular basis of the VHL hereditary cancer syndrome.
Nature reviews. Cancer 2002;2(9):673-82.
2002: Aiello Lloyd Paul; George Daniel J; Cahill Mark T; Wong Jun S; Cavallerano Jerry; Hannah Alison L; Kaelin William G
Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416.
Ophthalmology 2002;109(9):1745-51.
2002: Reddy Archana; Kaelin William G
Using cancer genetics to guide the selection of anticancer drug targets.
Current opinion in pharmacology 2002;2(4):366-73.
2002: Kaelin William G
How oxygen makes its presence felt.
Genes & development 2002;16(12):1441-5.
2002: Min Jung-Hyun; Yang Haifeng; Ivan Mircea; Gertler Frank; Kaelin William G; Pavletich Nikola P
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Science (New York, N.Y.) 2002;296(5574):1886-9.
2002: Seelan Ratnam S; Irwin Meredith; van der Stoop Petra; Qian Chiping; Kaelin William G; Liu Wanguo
The human p73 promoter: characterization and identification of functional E2F binding sites.
Neoplasia (New York, N.Y.) 2002;4(3):195-203.
2002: Kondo Keiichi; Klco Jeff; Nakamura Eijiro; Lechpammer Mirna; Kaelin William G
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
Cancer cell 2002;1(3):237-46.
2002: Hansen William J; Ohh Michael; Moslehi Javid; Kondo Keiichi; Kaelin William G; Welch William J
Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity.
Molecular and cellular biology 2002;22(6):1947-60.
2002: Ohh Michael; Kim William Y; Moslehi Javid J; Chen Yuzhi; Chau Vincent; Read Margaret A; Kaelin William G
An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.
EMBO reports 2002;3(2):177-82.
2001: Querido E; Blanchette P; Yan Q; Kamura T; Morrison M; Boivin D; Kaelin W G; Conaway R C; Conaway J W; Branton P E
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex.
Genes & development 2001;15(23):3104-17.
2001: Yang H; Kaelin W G
Molecular pathogenesis of the von Hippel-Lindau hereditary cancer syndrome: implications for oxygen sensing.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(9):447-55.
2001: Irwin M S; Kaelin W G
p53 family update: p73 and p63 develop their own identities.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(7):337-49.
2001: Kim T Y; Kaelin W G
Differential control of transcription by DNA-bound cyclins.
Molecular biology of the cell 2001;12(7):2207-17.
2001: Genbacev O; Krtolica A; Kaelin W; Fisher S J
Human cytotrophoblast expression of the von Hippel-Lindau protein is downregulated during uterine invasion in situ and upregulated by hypoxia in vitro.
Developmental biology 2001;233(2):526-36.
2001: Hoffman M A; Ohh M; Yang H; Klco J M; Ivan M; Kaelin W G
von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.
Human molecular genetics 2001;10(10):1019-27.
2001: Ivan M; Kondo K; Yang H; Kim W; Valiando J; Ohh M; Salic A; Asara J M; Lane W S; Kaelin W G
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
Science (New York, N.Y.) 2001;292(5516):464-8.
2001: Kondo K; Kaelin W G
The von Hippel-Lindau tumor suppressor gene.
Experimental cell research 2001;264(1):117-25.
2001: Irwin M S; Kaelin W G
Role of the newer p53 family proteins in malignancy.
Apoptosis : an international journal on programmed cell death 2001;6(1-2):17-29.
2001: Ivan M; Kaelin W G
The von Hippel-Lindau tumor suppressor protein.
Current opinion in genetics & development 2001;11(1):27-34.
2000: Brooks L A; Tidy J A; Gusterson B; Hiller L; O'Nions J; Gasco M; Marin M C; Farrell P J; Kaelin W G; Crook T
Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus.
Cancer research 2000;60(24):6875-7.
2000: Kung A L; Wang S; Klco J M; Kaelin W G; Livingston D M
Suppression of tumor growth through disruption of hypoxia-inducible transcription.
Nature medicine 2000;6(12):1335-40.
2000: Miyake S; Sellers W R; Safran M; Li X; Zhao W; Grossman S R; Gan J; DeCaprio J A; Adams P D; Kaelin W G
Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle.
Molecular and cellular biology 2000;20(23):8889-902.
2000: Siegert J L; Rushton J J; Sellers W R; Kaelin W G; Robbins P D
Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity.
Oncogene 2000;19(50):5703-11.
2000: Irwin M; Marin M C; Phillips A C; Seelan R S; Smith D I; Liu W; Flores E R; Tsai K Y; Jacks T; Vousden K H; Kaelin W G
Role for the p53 homologue p73 in E2F-1-induced apoptosis.
Nature 2000;407(6804):645-8.
2000: Lissy N A; Davis P K; Irwin M; Kaelin W G; Dowdy S F
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.
Nature 2000;407(6804):642-5.
2000: O'Hagan R C; Ohh M; David G; de Alboran I M; Alt F W; Kaelin W G; DePinho R A
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
Genes & development 2000;14(17):2185-91.
2000: Ohh M; Park C W; Ivan M; Hoffman M A; Kim T Y; Huang L E; Pavletich N; Chau V; Kaelin W G
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein.
Nature cell biology 2000;2(7):423-7.
2000: Marin M C; Jost C A; Brooks L A; Irwin M S; O'Nions J; Tidy J A; James N; McGregor J M; Harwood C A; Yulug I G; Vousden K H; Allday M J; Gusterson B; Ikawa S; Hinds P W; Crook T; Kaelin W G
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour.
Nature genetics 2000;25(1):47-54.
2000: Marin M C; Kaelin W G
p63 and p73: old members of a new family.
Biochimica et biophysica acta 2000;1470(3):M93-M100.
1999: Kaelin W G
The p53 gene family.
Oncogene 1999;18(53):7701-5.
1999: Ohh M; Takagi Y; Aso T; Stebbins C E; Pavletich N P; Zbar B; Conaway R C; Conaway J W; Kaelin W G
Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.
The Journal of clinical investigation 1999;104(11):1583-91.
1999: Kaelin W G
Choosing anticancer drug targets in the postgenomic era.
The Journal of clinical investigation 1999;104(11):1503-6.
1999: Kaelin W G
Taking aim at novel molecular targets in cancer therapy.
The Journal of clinical investigation 1999;104(11):1495.
1999: Kaelin W G
Functions of the retinoblastoma protein.
BioEssays : news and reviews in molecular, cellular and developmental biology 1999;21(11):950-8.
1999: Lai A; Lee J M; Yang W M; DeCaprio J A; Kaelin W G; Seto E; Branton P E
RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins.
Molecular and cellular biology 1999;19(10):6632-41.
1999: Koochekpour S; Jeffers M; Wang P H; Gong C; Taylor G A; Roessler L M; Stearman R; Vasselli J R; Stetler-Stevenson W G; Kaelin W G; Linehan W M; Klausner R D; Gnarra J R; Vande Woude G F
The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.
Molecular and cellular biology 1999;19(9):5902-12.
1999: Gong J G; Costanzo A; Yang H Q; Melino G; Kaelin W G; Levrero M; Wang J Y
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage.
Nature 1999;399(6738):806-9.
1999: Ohh M; Kaelin W G
The von Hippel-Lindau tumour suppressor protein: new perspectives.
Molecular medicine today 1999;5(6):257-63.
1999: Kaelin W G
Cancer. Many vessels, faulty gene.
Nature 1999;399(6733):203-4.
1999: Zbar B; Kaelin W; Maher E; Richard S
Third International Meeting on von Hippel-Lindau disease.
Cancer research 1999;59(9):2251-3.
1999: Zeng X; Chen L; Jost C A; Maya R; Keller D; Wang X; Kaelin W G; Oren M; Chen J; Lu H
MDM2 suppresses p73 function without promoting p73 degradation.
Molecular and cellular biology 1999;19(5):3257-66.
1999: Kamura T; Koepp D M; Conrad M N; Skowyra D; Moreland R J; Iliopoulos O; Lane W S; Kaelin W G; Elledge S J; Conaway R C; Harper J W; Conaway J W
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
Science (New York, N.Y.) 1999;284(5414):657-61.
1999: Stebbins C E; Kaelin W G; Pavletich N P
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.
Science (New York, N.Y.) 1999;284(5413):455-61.
1999: Kaelin W G
The emerging p53 gene family.
Journal of the National Cancer Institute 1999;91(7):594-8.
1999: Chen Y N; Sharma S K; Ramsey T M; Jiang L; Martin M S; Baker K; Adams P D; Bair K W; Kaelin W G
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4325-9.
1999: Adams P D; Li X; Sellers W R; Baker K B; Leng X; Harper J W; Taya Y; Kaelin W G
Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes.
Molecular and cellular biology 1999;19(2):1068-80.
1998: Adams P D; Kaelin W G
Negative control elements of the cell cycle in human tumors.
Current opinion in cell biology 1998;10(6):791-7.
1998: Kamura T; Sato S; Haque D; Liu L; Kaelin W G; Conaway R C; Conaway J W
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
Genes & development 1998;12(24):3872-81.
1998: Lieubeau-Teillet B; Rak J; Jothy S; Iliopoulos O; Kaelin W; Kerbel R S
von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids.
Cancer research 1998;58(21):4957-62.
1998: Marin M C; Jost C A; Irwin M S; DeCaprio J A; Caput D; Kaelin W G
Viral oncoproteins discriminate between p53 and the p53 homolog p73.
Molecular and cellular biology 1998;18(11):6316-24.
1998: Kaelin W G; Maher E R
The VHL tumour-suppressor gene paradigm.
Trends in genetics : TIG 1998;14(10):423-6.
1998: Iliopoulos O; Ohh M; Kaelin W G
pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11661-6.
1998: Kaelin W G
Another p53 Doppelgänger?
Science (New York, N.Y.) 1998;281(5373):57-8.
1998: Kaelin W G; Iliopoulos O; Lonergan K M; Ohh M
Functions of the von Hippel-Lindau tumour suppressor protein.
Journal of internal medicine 1998;243(6):535-9.
1998: Ohh M; Yauch R L; Lonergan K M; Whaley J M; Stemmer-Rachamimov A O; Louis D N; Gavin B J; Kley N; Kaelin W G; Iliopoulos O
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix.
Molecular cell 1998;1(7):959-68.
1998: Lonergan K M; Iliopoulos O; Ohh M; Kamura T; Conaway R C; Conaway J W; Kaelin W G
Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2.
Molecular and cellular biology 1998;18(2):732-41.
1998: Sellers W R; Novitch B G; Miyake S; Heith A; Otterson G A; Kaye F J; Lassar A B; Kaelin W G
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth.
Genes & development 1998;12(1):95-106.
1997: Kaelin W G
Alterations in G1/S cell-cycle control contributing to carcinogenesis.
Annals of the New York Academy of Sciences 1997;833():29-33.
1997: Maher E R; Kaelin W G
von Hippel-Lindau disease.
Medicine 1997;76(6):381-91.
1997: Sellers W R; Kaelin W G
Role of the retinoblastoma protein in the pathogenesis of human cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(11):3301-12.
1997: Parr M J; Manome Y; Tanaka T; Wen P; Kufe D W; Kaelin W G; Fine H A
Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector.
Nature medicine 1997;3(10):1145-9.
1997: Jost C A; Marin M C; Kaelin W G
p73 is a simian [correction of human] p53-related protein that can induce apoptosis.
Nature 1997;389(6647):191-4.
1997: Iliopoulos O; Kaelin W G
The molecular basis of von Hippel-Lindau disease.
Molecular medicine (Cambridge, Mass.) 1997;3(5):289-93.
1997: Corless C L; Kibel A S; Iliopoulos O; Kaelin W G
Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues.
Human pathology 1997;28(4):459-64.
1997: Adams P D; Lopez P; Sellers W R; Kaelin W G
Fluorescence-activated cell sorting of transfected cells.
Methods in enzymology 1997;283():59-72.
1997: Kaelin W G
Recent insights into the functions of the retinoblastoma susceptibility gene product.
Cancer investigation 1997;15(3):243-54.
1996: Adams P D; Sellers W R; Sharma S K; Wu A D; Nalin C M; Kaelin W G
Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors.
Molecular and cellular biology 1996;16(12):6623-33.
1996: Iliopoulos O; Levy A P; Jiang C; Kaelin W G; Goldberg M A
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10595-9.
1996: Neuman E; Sellers W R; McNeil J A; Lawrence J B; Kaelin W G
Structure and partial genomic sequence of the human E2F1 gene.
Gene 1996;173(2):163-9.
1996: Grafi G; Burnett R J; Helentjaris T; Larkins B A; DeCaprio J A; Sellers W R; Kaelin W G
A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8962-7.
1996: Los M; Jansen G H; Kaelin W G; Lips C J; Blijham G H; Voest E E
Expression pattern of the von Hippel-Lindau protein in human tissues.
Laboratory investigation; a journal of technical methods and pathology 1996;75(2):231-8.
1996: Sellers W R; Kaelin W G
RB [corrected] as a modulator of transcription.
Biochimica et biophysica acta 1996;1288(1):M1-5.
1996: Jost C A; Ginsberg D; Kaelin W G
A conserved region of unknown function participates in the recognition of E2F family members by the adenovirus E4 ORF 6/7 protein.
Virology 1996;220(1):78-90.
1996: Field S J; Tsai F Y; Kuo F; Zubiaga A M; Kaelin W G; Livingston D M; Orkin S H; Greenberg M E
E2F-1 functions in mice to promote apoptosis and suppress proliferation.
Cell 1996;85(4):549-61.
1996: Adams P D; Kaelin W G
The cellular effects of E2F overexpression.
Current topics in microbiology and immunology 1996;208():79-93.
1995: Sellers W R; Rodgers J W; Kaelin W G
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11544-8.
1995: Kibel A; Iliopoulos O; DeCaprio J A; Kaelin W G
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C.
Science (New York, N.Y.) 1995;269(5229):1444-6.
1995: Neuman E; Flemington E K; Sellers W R; Kaelin W G
Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter.
Molecular and cellular biology 1995;15(8):4660.
1995: Iliopoulos O; Kibel A; Gray S; Kaelin W G
Tumour suppression by the human von Hippel-Lindau gene product.
Nature medicine 1995;1(8):822-6.
1995: Adams P D; Kaelin W G
Transcriptional control by E2F.
Seminars in cancer biology 1995;6(2):99-108.
1995: Qin X Q; Livingston D M; Ewen M; Sellers W R; Arany Z; Kaelin W G
The transcription factor E2F-1 is a downstream target of RB action.
Molecular and cellular biology 1995;15(2):742-55.
1994: Qin X Q; Livingston D M; Kaelin W G; Adams P D
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10918-22.
1994: Neuman E; Flemington E K; Sellers W R; Kaelin W G
Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter.
Molecular and cellular biology 1994;14(10):6607-15.
1994: Krek W; Ewen M E; Shirodkar S; Arany Z; Kaelin W G; Livingston D M
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase.
Cell 1994;78(1):161-72.
1994: Li Y; Slansky J E; Myers D J; Drinkwater N R; Kaelin W G; Farnham P J
Cloning, chromosomal location, and characterization of mouse E2F1.
Molecular and cellular biology 1994;14(3):1861-9.
1993: Livingston D M; Kaelin W; Chittenden T; Qin X
Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).
British journal of cancer 1993;68(2):264-8.
1993: Flemington E K; Speck S H; Kaelin W G
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):6914-8.
1993: Wang C Y; Petryniak B; Thompson C B; Kaelin W G; Leiden J M
Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.
Science (New York, N.Y.) 1993;260(5112):1330-5.
1993: Slansky J E; Li Y; Kaelin W G; Farnham P J
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.
Molecular and cellular biology 1993;13(3):1610-8.
1992: Kaelin W G; Krek W; Sellers W R; DeCaprio J A; Ajchenbaum F; Fuchs C S; Chittenden T; Li Y; Farnham P J; Blanar M A
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties.
Cell 1992;70(2):351-64.
1992: Qin X Q; Chittenden T; Livingston D M; Kaelin W G
Identification of a growth suppression domain within the retinoblastoma gene product.
Genes & development 1992;6(6):953-64.
1991: Walling D M; Kaelin W G
Pyomyositis in patients with diabetes mellitus.
Reviews of infectious diseases 1991;13(5):797-802.
1991: Chittenden T; Livingston D M; Kaelin W G
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein.
Cell 1991;65(6):1073-82.
1991: Kaelin W G; Pallas D C; DeCaprio J A; Kaye F J; Livingston D M
Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product.
Cell 1991;64(3):521-32.
1991: Chittenden T; Livingston D M; Kaelin W G
RB associates with an E2F-like, sequence-specific DNA-binding protein.
Cold Spring Harbor symposia on quantitative biology 1991;56():187-95.
1990: Kaelin W G; Ewen M E; Livingston D M
Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.
Molecular and cellular biology 1990;10(7):3761-9.
1984: Kaelin W G; Shrivastav S; Jirtle R L
Blood flow to primary tumors and lymph node metastases in SMT-2A tumor-bearing rats following intravenous flunarizine.
Cancer research 1984;44(3):896-9.
1983: Shrivastav S; Kaelin W G; Joines W T; Jirtle R L
Microwave hyperthermia and its effect on tumor blood flow in rats.
Cancer research 1983;43(10):4665-9.
1982: Kaelin W G; Shrivastav S; Shand D G; Jirtle R L
Effect of verapamil on malignant tissue blood flow in SMT-2A tumor-bearing rats.
Cancer research 1982;42(10):3944-9.

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