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Christoph Kaether

Research Profile

Chemicals & Drugs

Anatomy

Cell Line

Disorders

Alzheimer's Disease

Living Beings

Physiology

Concepts & Ideas

Protein Structure, Tertiary

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Publications

TOP 3
Christian Haass; Christoph Kaether; Gopal Thinakaran; Sangram Sisodia
Trafficking and proteolytic processing of APP.
Matthias Fassler; Xiaolin Li; Christoph Kaether
Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.
Katrin Juenemann; Christoph Kaether; Denise Reichmann; Cornelis F Calkhoven; Christina Weisse; Gabriele Schilling
Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death.

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All Publications

2012: Christian Haass; Christoph Kaether; Gopal Thinakaran; Sangram Sisodia
Trafficking and proteolytic processing of APP.
Cold Spring Harbor perspectives in medicine 2012;2(5):a006270.
2011: Matthias Fassler; Xiaolin Li; Christoph Kaether
Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.
The Journal of biological chemistry 2011;286(44):38390-6.
2011: Katrin Juenemann; Christoph Kaether; Denise Reichmann; Cornelis F Calkhoven; Christina Weisse; Gabriele Schilling
Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death.
Neurotoxicity research 2011;20(2):120-33.
2011: Christina Valkova; Marina Albrizio; Ira V Röder; Michael Schwake; Romeo Betto; Ruediger Rudolf; Christoph Kaether
Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(2):621-5.
2010: Kerstin Huenniger; Andreas Krämer; Malle Soom; Iree Chang; Matthias Köhler; Reinhard Depping; Ralph H Kehlenbach; Christoph Kaether
Notch1 signaling is mediated by importins alpha 3, 4, and 7.
Cellular and molecular life sciences : CMLS 2010;67(18):3187-96.
2010: Ralf P Friedrich; Katharina Tepper; Raik Rönicke; Malle Soom; Martin Westermann; Klaus Reymann; Christoph Kaether; Marcus Fändrich
Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):1942-7.
2010: Matthias Fassler; Michael Zocher; Sebastian Klare; Alerie Guzman de la Fuente; Johanna Scheuermann; Anja Capell; Christian Haass; Christina Valkova; Anbazhagan Veerappan; Dirk Schneider; Christoph Kaether
Masking of transmembrane-based retention signals controls ER export of gamma-secretase.
Traffic (Copenhagen, Denmark) 2010;11(2):250-8.
2010: Marcel Kramer; Janne Boeck; Daniela Reichenbach; Christoph Kaether; Stefan Schreiber; Matthias Platzer; Philip Rosenstiel; Klaus Huse
NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner.
BMC research notes 2010;3():224.
2009: Ingo Kurth; Torsten Pamminger; J Christopher Hennings; Désirée Soehendra; Antje K Huebner; Annelies Rotthier; Jonathan Baets; Jan Senderek; Haluk Topaloglu; Sandra A Farrell; Gudrun Nürnberg; Peter Nürnberg; Peter De Jonghe; Andreas Gal; Christoph Kaether; Vincent Timmerman; Christian A Hübner
Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy.
Nature genetics 2009;41(11):1179-81.
2009: Laura Bloch; Olga Sineshchekova; Daniela Reichenbach; Karina Reiss; Paul Saftig; Makoto Kuro-o; Christoph Kaether
Klotho is a substrate for alpha-, beta- and gamma-secretase.
FEBS letters 2009;583(19):3221-4.
2007: Christoph Kaether; Johanna Scheuermann; Matthias Fassler; Sonja Zilow; Keiro Shirotani; Christina Valkova; Bozidar Novak; Slavomir Kacmar; Harald Steiner; Christian Haass
Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.
EMBO reports 2007;8(8):743-8.
2006: Claire Goldsbury; Maria-Magdalena Mocanu; Edda Thies; Christoph Kaether; Christian Haass; Patrick Keller; Jacek Biernat; Eckhard Mandelkow; Eva-Maria Mandelkow
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.
Traffic (Copenhagen, Denmark) 2006;7(7):873-88.
2006: Aya Yamasaki; Stefan Eimer; Masayasu Okochi; Agata Smialowska; Christoph Kaether; Ralf Baumeister; Christian Haass; Harald Steiner
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3821-8.
2006: Christoph Kaether; Stephanie Schmitt; Michael Willem; Christian Haass
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
Traffic (Copenhagen, Denmark) 2006;7(4):408-15.
2006: Christoph Kaether; Christian Haass; Harald Steiner
Assembly, trafficking and function of gamma-secretase.
Neuro-degenerative diseases 2006;3(4-5):275-83.
2005: Tobias Straub; Martin F Neumann; Matthias Prestel; Elisabeth Kremmer; Christoph Kaether; Christian Haass; Peter B Becker
Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment.
Chromosoma 2005;114(5):352-64.
2005: Anja Capell; Dirk Beher; Stefan Prokop; Harald Steiner; Christoph Kaether; Mark S Shearman; Christian Haass
Gamma-secretase complex assembly within the early secretory pathway.
The Journal of biological chemistry 2005;280(8):6471-8.
2004: Christoph Kaether; Anja Capell; Dieter Edbauer; Edith Winkler; Bozidar Novak; Harald Steiner; Christian Haass
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
The EMBO journal 2004;23(24):4738-48.
2004: Christoph Kaether; Christian Haass
A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation.
The Journal of cell biology 2004;167(5):809-12.
2004: Dieter Edbauer; Christoph Kaether; Harald Steiner; Christian Haass
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.
The Journal of biological chemistry 2004;279(36):37311-5.
2003: Anja Capell; Christoph Kaether; Dieter Edbauer; Keiro Shirotani; Sabine Merkl; Harald Steiner; Christian Haass
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.
The Journal of biological chemistry 2003;278(52):52519-23.
2002: Sven Lammich; Masayasu Okochi; Masatoshi Takeda; Christoph Kaether; Anja Capell; Ann-Katrin Zimmer; Dieter Edbauer; Jochen Walter; Harald Steiner; Christian Haass
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
The Journal of biological chemistry 2002;277(47):44754-9.
2002: Christoph Kaether; Sven Lammich; Dieter Edbauer; Michaela Ertl; Jens Rietdorf; Anja Capell; Harald Steiner; Christian Haass
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
The Journal of cell biology 2002;158(3):551-61.
2002: Tobias Moehlmann; Edith Winkler; Xuefeng Xia; Dieter Edbauer; Jill Murrell; Anja Capell; Christoph Kaether; Hui Zheng; Bernardino Ghetti; Christian Haass; Harald Steiner
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8025-30.
2002: Amin Rustom; Mark Bajohrs; Christoph Kaether; Patrick Keller; Derek Toomre; Denis Corbeil; Hans-Hermann Gerdes
Selective delivery of secretory cargo in Golgi-derived carriers of nonepithelial cells.
Traffic (Copenhagen, Denmark) 2002;3(4):279-88.
2001: J Walter; Christoph Kaether; H Steiner; Christian Haass
The cell biology of Alzheimer's disease: uncovering the secrets of secretases.
Current opinion in neurobiology 2001;11(5):585-90.
2001: Jochen Walter; Regina Fluhrer; B Hartung; Michael Willem; Christoph Kaether; Anja Capell; Sven Lammich; Gerd Multhaup; Christian Haass
Phosphorylation regulates intracellular trafficking of beta-secretase.
The Journal of biological chemistry 2001;276(18):14634-41.
1999: W Tvaruskó; Martin Bentele; T Misteli; Ruediger Rudolf; Christoph Kaether; David L Spector; Hans-Hermann Gerdes; Roland Eils
Time-resolved analysis and visualization of dynamic processes in living cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7950-5.
1999: Christoph Kaether; Hans-Hermann Gerdes
Monitoring of protein secretion with green fluorescent protein.
Methods in enzymology 1999;302():11-9.
1997: Christoph Kaether; Thorsten Salm; MM Glombik; Wolfhard Almers; Hans-Hermann Gerdes
Targeting of green fluorescent protein to neuroendocrine secretory granules: a new tool for real time studies of regulated protein secretion.
European journal of cell biology 1997;74(2):133-42.
1997: I Wacker; Christoph Kaether; A Krömer; A Migala; Wolfhard Almers; Hans-Hermann Gerdes
Microtubule-dependent transport of secretory vesicles visualized in real time with a GFP-tagged secretory protein.
Journal of cell science 1997;110 ( Pt 13)():1453-63.
1997: T Lang; I Wacker; Jürgen A Steyer; Christoph Kaether; I Wunderlich; Thierry Soldati; Hans-Hermann Gerdes; Wolfhard Almers
Ca2+-triggered peptide secretion in single cells imaged with green fluorescent protein and evanescent-wave microscopy.
Neuron 1997;18(6):857-63.
1996: Hans-Hermann Gerdes; Christoph Kaether
Green fluorescent protein: applications in cell biology.
FEBS letters 1996;389(1):44-7.
1995: Christoph Kaether; Hans-Hermann Gerdes
Visualization of protein transport along the secretory pathway using green fluorescent protein.
FEBS letters 1995;369(2-3):267-71.