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Pawel Kafarski

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Giuseppe Forlani; Samuele Giberti; Pawel Kafarski; Michele Bertazzini; Dorota Wieczorek; Jacek Lipok
Sublethal detergent concentrations increase metabolization of recalcitrant polyphosphonates by the cyanobacterium Spirulina platensis.
Giuseppe Forlani; Massimo Fusetti; Andrzej Joachimiak; Bogusław Nocek; Davide Petrollino; Letizia Romanini; Lukasz Berlicki; Pawel Kafarski
Δ1-pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo.
Lukasz Berlicki; Arkadiusz Białas; Marta Bochno; Agnieszka Grabowiecka; Paulina Kosikowska; Pawel Kafarski
N-substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases.

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All Publications

2013: Giuseppe Forlani; Samuele Giberti; Pawel Kafarski; Michele Bertazzini; Dorota Wieczorek; Jacek Lipok
Sublethal detergent concentrations increase metabolization of recalcitrant polyphosphonates by the cyanobacterium Spirulina platensis.
Environmental science and pollution research international 2013;20(5):3263-70.
2012: Giuseppe Forlani; Massimo Fusetti; Andrzej Joachimiak; Bogusław Nocek; Davide Petrollino; Letizia Romanini; Lukasz Berlicki; Pawel Kafarski
Δ1-pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo.
Amino acids 2012;42(6):2283-91.
2012: Lukasz Berlicki; Arkadiusz Białas; Marta Bochno; Agnieszka Grabowiecka; Paulina Kosikowska; Pawel Kafarski
N-substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases.
Amino acids 2012;42(5):1937-45.
2012: Łukasz Górecki; Katarzyna Slepokura; Pawel Kafarski; Artur Mucha; Lukasz Berlicki; Ewa Rudzińska-Szostak
Phosphorylation as a method of tuning the enantiodiscrimination potency of quinine--an NMR study.
Chirality 2012;24(4):318-28.
2011: Edyta Podstawka-Proniewicz; Pawel Kafarski; Younkyoo Kim; Natalia Piergies; Dominika Skołuba; Leonard M Proniewicz
Vibrational characterization of L-leucine phosphonate analogues: FT-IR, FT-Raman, and SERS spectroscopy studies and DFT calculations.
The journal of physical chemistry. A 2011;115(40):11067-78.
2011: Artur Mucha; Pawel Kafarski; Lukasz Berlicki
Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry.
Journal of medicinal chemistry 2011;54(17):5955-80.
2011: Magdalena Klimek-Ochab; Barbara Lejczak; Ewa Zymańczyk-Duda; Małgorzata Brzezińska-Rodak; Pawel Kafarski
Comparative study of fungal cell disruption--scope and limitations of the methods.
Folia microbiologica 2011;56(5):469-75.
2011: Giuseppe Forlani; Pawel Kafarski; Valentina Prearo; Dorota Wieczorek; Jacek Lipok
Phosphonate degradation by Spirulina strains: cyanobacterial biofilters for the removal of anticorrosive polyphosphonates from wastewater.
Enzyme and microbial technology 2011;48(3):299-305.
2011: Kinga Radwan-Olszewska; Francisco Palacios; Pawel Kafarski
Selective synthesis of α-fluoro-β-keto- and α-fluoro-β-aminophosphonates via electrophilic fluorination by selectfluor.
The Journal of organic chemistry 2011;76(4):1170-3.
2010: Artur Mucha; Marcin Drag; John P Dalton; Pawel Kafarski
Metallo-aminopeptidase inhibitors.
Biochimie 2010;92(11):1509-29.
2010: Stamatia Vassiliou; Paulina Kosikowska; Agnieszka Grabowiecka; Athanasios Yiotakis; Pawel Kafarski; Lukasz Berlicki
Computer-aided optimization of phosphinic inhibitors of bacterial ureases.
Journal of medicinal chemistry 2010;53(15):5597-606.
2010: Izabela Jasicka-Misiak; Jacek Lipok; Izabela A Swider; Pawel Kafarski
Possible fungistatic implications of betulin presence in betulaceae plants and their hymenochaetaceae parasitic fungi.
Zeitschrift für Naturforschung. C, Journal of biosciences 2010;65(3-4):201-6.
2010: Sheena McGowan; Christine A Oellig; Woldeamanuel A Birru; Tom T Caradoc-Davies; Colin M Stack; Jonathan Lowther; Tina S Skinner-Adams; Artur Mucha; Pawel Kafarski; Jolanta Grembecka; Katharine R Trenholme; Ashley M Buckle; Donald L Gardiner; John P Dalton; James C Whisstock
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2449-54.
2010: Ewa Matczak-Jon; Teresa Kowalik-Jankowska; Katarzyna Slepokura; Pawel Kafarski; Anna Rajewska
Specificity of the zinc(II), magnesium(II) and calcium(II) complexation by (pyridin-2-yl)aminomethane-1,1-diphosphonic acids and related 1,3-(thiazol-2-yl) and 1,3-(benzothiazol-2-yl) derivatives.
Dalton transactions (Cambridge, England : 2003) 2010;39(5):1207-21.
2010: Tina S Skinner-Adams; Colin M Stack; Katharine R Trenholme; Chris L Brown; Jolanta Grembecka; Jonathan Lowther; Artur Mucha; Marcin Drag; Pawel Kafarski; Sheena McGowan; James C Whisstock; Donald L Gardiner; John P Dalton
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
Trends in biochemical sciences 2010;35(1):53-61.
2010: Andrea Occhipinti; Łukasz Berlicki; Samuele Giberti; Gabriela Dziedzioła; Pawel Kafarski; Giuseppe Forlani
Effectiveness and mode of action of phosphonate inhibitors of plant glutamine synthetase.
Pest management science 2010;66(1):51-8.
2010: Ewa Rudzińska; Gabriela Dziedzioła; Lukasz Berlicki; Pawel Kafarski
Enantiodifferentiation of alpha-hydroxyalkanephosphonic acids in 31P NMR with application of alpha-cyclodextrin as chiral discriminating agent.
Chirality 2010;22(1):63-8.
2009: Ewa Matczak-Jon; Katarzyna Slepokura; Pawel Kafarski; Izabela Skrzyńska; Marek Jon
Conformational isomers of the [(5-methyl-2-pyridinio)aminomethylene]diphosphonate dianion and [(5-methyl-2-pyridyl)aminomethylene]diphosphonate trianion in salts with 4-aminopyridine and ammonia.
Acta crystallographica. Section C, Crystal structure communications 2009;65(Pt 6):o261-6.
2009: Marek Doskocz; Agnieszka Strupińska; Szczepan Roszak; Monika Prokopowicz; Leo H Koole; Pawel Kafarski
Theoretical study of spin-spin coupling across the hydrogen (O-H...N) bond in adenosine derivatives.
Journal of molecular modeling 2009;15(6):651-8.
2009: Sheena McGowan; Corrine J Porter; Jonathan Lowther; Colin M Stack; Sarah J Golding; Tina S Skinner-Adams; Katharine R Trenholme; Franka Teuscher; Sheila M Donnelly; Jolanta Grembecka; Artur Mucha; Pawel Kafarski; Ross Degori; Ashley M Buckle; Donald L Gardiner; James C Whisstock; John P Dalton
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2537-42.
2008: Edyta Podstawka; Pawel Kafarski; Leonard M Proniewicz
Structural properties of L-X-L-Met-L-Ala phosphonate tripeptides: a combined FT-IR, FT-RS, and SERS spectroscopy studies and DFT calculations.
The journal of physical chemistry. A 2008;112(46):11744-55.
2008: R Latajka; M Jewginski; Maciej Makowski; M Pawełczak; T Huber; N Sewald; Pawel Kafarski
Pentapeptides containing two dehydrophenylalanine residues--synthesis, structural studies and evaluation of their activity towards cathepsin C.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(10):1084-95.
2008: Stamatia Vassiliou; Agnieszka Grabowiecka; Paulina Kosikowska; Athanasios Yiotakis; Pawel Kafarski; Łukasz Berlicki
Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases.
Journal of medicinal chemistry 2008;51(18):5736-44.
2008: Eithne Cunningham; Marcin Drag; Pawel Kafarski; Angus Bell
Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors.
Antimicrobial agents and chemotherapy 2008;52(9):3221-8.
2008: Barbara Jaskula; Pawel Kafarski; Guido Aerts; Luc De Cooman
A kinetic study on the isomerization of hop alpha-acids.
Journal of agricultural and food chemistry 2008;56(15):6408-15.
2008: Giuseppe Forlani; Andrea Occhipinti; Lukasz Berlicki; Gabriela Dziedzioła; Anna Wieczorek; Pawel Kafarski
Tailoring the structure of aminobisphosphonates to target plant P5C reductase.
Journal of agricultural and food chemistry 2008;56(9):3193-9.
2008: Giuseppe Forlani; Mauro Pavan; Magdalena Gramek; Pawel Kafarski; Jacek Lipok
Biochemical bases for a widespread tolerance of cyanobacteria to the phosphonate herbicide glyphosate.
Plant & cell physiology 2008;49(3):443-56.
2008: Artur Mucha; Michael Lämmerhofer; Wolfgang Lindner; Małgorzata Pawełczak; Pawel Kafarski
Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase.
Bioorganic & medicinal chemistry letters 2008;18(5):1550-4.
2008: Marek Lisowski; R Latajka; Boleslaw Picur; Tadeusz Lis; Iwona Bryndal; Maria Rospenk; Maciej Makowski; Pawel Kafarski
Combined effect of the DeltaPhe or DeltaAla residue and the p-nitroanilide group on a didehydropeptides conformation.
Biopolymers 2008;89(3):220-34.
2008: Ewelina Minta; Pawel Kafarski; Jean Martinez; Valérie Rolland
Synthesis of cyclooctapeptides: constraints analogues of the peptidic neurotoxin, omega-agatoxine IVB-an experimental point of view.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(3):267-77.
2007: Tina S Skinner-Adams; Jonathan Lowther; Franka Teuscher; Colin M Stack; Jolanta Grembecka; Artur Mucha; Pawel Kafarski; Katharine R Trenholme; John P Dalton; Donald L Gardiner
Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.
Journal of medicinal chemistry 2007;50(24):6024-31.
2007: Ewa Rudzińska; Łukasz Berlicki; Artur Mucha; Pawel Kafarski
Analysis of pD-dependent complexation of N-benzyloxycarbonylaminophosphonic acids by alpha-cyclodextrin. Enantiodifferentiation of phosphonic acid pKa values.
Chirality 2007;19(10):764-8.
2007: Franka Teuscher; Jonathan Lowther; Tina S Skinner-Adams; Tobias Spielmann; Matthew W A Dixon; Colin M Stack; Sheila Donnelly; Artur Mucha; Pawel Kafarski; Stamatia Vassiliou; Donald L Gardiner; John P Dalton; Katharine R Trenholme
The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.
The Journal of biological chemistry 2007;282(42):30817-26.
2007: Giuseppe Forlani; Samuele Giberti; Lukasz Berlicki; Davide Petrollino; Pawel Kafarski
Plant P5C reductase as a new target for aminomethylenebisphosphonates.
Journal of agricultural and food chemistry 2007;55(11):4340-7.
2007: Stamatia Vassiliou; Metaxia Xeilari; Athanasios Yiotakis; Jolanta Grembecka; Małgorzata Pawełczak; Pawel Kafarski; Artur Mucha
A synthetic method for diversification of the P1' substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1' binding pockets of leucine aminopeptidases.
Bioorganic & medicinal chemistry 2007;15(9):3187-200.
2007: Colin M Stack; Jonathan Lowther; Eithne Cunningham; Sheila Donnelly; Donald L Gardiner; Katharine R Trenholme; Tina S Skinner-Adams; Franka Teuscher; Jolanta Grembecka; Artur Mucha; Pawel Kafarski; Linda Lua; Angus Bell; John P Dalton
Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development.
The Journal of biological chemistry 2007;282(3):2069-80.
2007: Ewa Rudzińska; Anna Poliwoda; Łukasz Berlicki; Artur Mucha; Pawel Dzygiel; Piotr P Wieczorek; Pawel Kafarski
Enantiodifferentiation of N-benzyloxycarbonylaminophosphonic and phosphinic acids and their esters using cyclodextrins by means of capillary electrophoresis.
Journal of chromatography. A 2007;1138(1-2):284-90.
2006: Beatrix Preinerstorfer; Dieter Lubda; Artur Mucha; Pawel Kafarski; Wolfgang Lindner; Michael Lämmerhofer
Stereoselective separations of chiral phosphinic acid pseudodipeptides by CEC using silica monoliths modified with an anion-exchange-type chiral selector.
Electrophoresis 2006;27(21):4312-20.
2006: Monika Jagiełło; Ewelina Minta; Katarzyna Chojnacka; Pawel Kafarski
Mode of biosorption of chromium(III) by Spirulina species cells from aqueous solutions.
Water environment research : a research publication of the Water Environment Federation 2006;78(7):740-3.
2006: Lukasz Berlicki; Pawel Kafarski
Computer-aided analysis of the interactions of glutamine synthetase with its inhibitors.
Bioorganic & medicinal chemistry 2006;14(13):4578-85.
2006: Ewa Matczak-Jon; Barbara Kurzak; Pawel Kafarski; Agnieszka Woźna
Coordination abilities of piperyd-1-yl-methane-1,1-diphosphonic acids towards zinc(II), magnesium(II) and calcium(II): potentiometric and NMR studies.
Journal of inorganic biochemistry 2006;100(7):1155-66.
2006: Artur Mucha; A Kunert; Jolanta Grembecka; M Pawełczak; Pawel Kafarski
A phosphonamidate containing aromatic N-terminal amino group as inhibitor of leucine aminopeptidase-design, synthesis and stability.
European journal of medicinal chemistry 2006;41(6):768-72.
2006: Małgorzata Brzezińska-Rodak; Ewa Zymańczyk-Duda; Magdalena Klimek-Ochab; Pawel Kafarski; Barbara Lejczak
A simple and green procedure for the microbial effective synthesis of 1-phenylethyl alcohol in both enantiomeric forms.
Biotechnology letters 2006;28(7):511-3.
2006: Ewa Matczak-Jon; Katarzyna Slepokura; Pawel Kafarski
[(5-Bromopyridinium-2-ylamino)(phosphono)methyl]phosphonate.
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 3):o132-5.
2006: Giuseppe Forlani; Agnieszka Obojska; Łukasz Berlicki; Pawel Kafarski
Phosphinothricin analogues as inhibitors of plant glutamine synthetases.
Journal of agricultural and food chemistry 2006;54(3):796-802.
2005: Łukasz Berlicki; Agnieszka Obojska; Giuseppe Forlani; Pawel Kafarski
Design, synthesis, and activity of analogues of phosphinothricin as inhibitors of glutamine synthetase.
Journal of medicinal chemistry 2005;48(20):6340-9.
2005: Marcin Drag; Jolanta Grembecka; Małgorzata Pawełczak; Pawel Kafarski
alpha-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine- and neutral aminopeptidases.
European journal of medicinal chemistry 2005;40(8):764-71.
2005: Izabela Jasicka-Misiak; Piotr P Wieczorek; Pawel Kafarski
Crotonic acid as a bioactive factor in carrot seeds (Daucus carota L.).
Phytochemistry 2005;66(12):1485-91.
2005: Ewa Matczak-Jon; Veneta Videnova-Adrabińska; Agnieszka Burzyńska; Pawel Kafarski; Tadeusz Lis
Solid-state molecular organization and solution behavior of methane-1,1-diphosphonic acid derivatives of heterocyclic amines: the role of the topochemical ring modification and the intramolecular hydrogen bonds in monosubstituted piperid-1-ylmethane-1,1-diphosphonic acids.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(8):2357-72.
2004: Izabela Jasicka-Misiak; Jacek Lipok; Ewa M Nowakowska; Piotr P Wieczorek; Piotr Młynarz; Pawel Kafarski
Antifungal activity of the carrot seed oil and its major sesquiterpene compounds.
Zeitschrift für Naturforschung. C, Journal of biosciences 2004;59(11-12):791-6.
2004: Beata Gasowska; Pawel Kafarski; Hubert Wojtasek
Interaction of mushroom tyrosinase with aromatic amines, o-diamines and o-aminophenols.
Biochimica et biophysica acta 2004;1673(3):170-7.
2004: Artur Mucha; Małgorzata Paweł; Józef Hurek; Pawel Kafarski
Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin C.
Bioorganic & medicinal chemistry letters 2004;14(12):3113-6.
2004: Agnieszka Obojska; Lukasz Berlicki; Pawel Kafarski; Barbara Lejczak; Milvia Chicca; Giuseppe Forlani
Herbicidal pyridyl derivatives of aminomethylene-bisphosphonic acid inhibit plant glutamine synthetase.
Journal of agricultural and food chemistry 2004;52(11):3337-44.
2004: Marcin Drag; Adam Jezierski; Pawel Kafarski
First example of the chemical, oxidative cleavage of the C-P bond in aminophosphonate chemistry. The oxidation of 1-amino-1-(3,4-dihydroxyphenyl)methylphosphonic acid by NaIO4.
Chemical communications (Cambridge, England) 2004;(9):1132-3.
2004: John M Sanders; Subhash Ghosh; Julian M W Chan; Gary A Meints; Hong Wang; Amy M Raker; Yongcheng Song; Alison Colantino; Agnieszka Burzynska; Pawel Kafarski; Craig Morita; Eric Oldfield
Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.
Journal of medicinal chemistry 2004;47(2):375-84.
2003: John M Sanders; Aurora Ortiz Gómez; Junhong Mao; Gary A Meints; Erin M Van Brussel; Agnieszka Burzynska; Pawel Kafarski; Dolores González-Pacanowska; Eric Oldfield
3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.
Journal of medicinal chemistry 2003;46(24):5171-83.
2003: Ewa Rudzińska; Piotr P Wieczorek; Pawel Kafarski
Separation of aminoalkanephosphonic acid enantiomers by indirect UV detection capillary electrophoresis with application of cyclodextrins.
Electrophoresis 2003;24(15):2693-7.
2003: Jolanta Grembecka; Artur Mucha; Tomasz Cierpicki; Pawel Kafarski
The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.
Journal of medicinal chemistry 2003;46(13):2641-55.
2003: Marcin Drag; Malgorzata Pawelczak; Pawel Kafarski
Stereoselective synthesis of 1-aminoalkanephosphonic acids with two chiral centers and their activity towards leucine aminopeptidase.
Chirality 2003;15 Suppl():S104-7.
2002: Ewa Rudzińska; Pawel Dzygiel; Piotr P Wieczorek; Pawel Kafarski
Separation of aromatic aminophosphonic acid enantiomers by capillary electrophoresis with the application of cyclodextrins.
Journal of chromatography. A 2002;979(1-2):115-22.
2002: Małorzata Brzezińska-Rodak; Ewa Zymańczyk-Duda; Pawel Kafarski; Barbara Lejczak
Application of fungi as biocatalysts for the reduction of diethyl 1-oxoalkylphosphonates in anhydrous hexane.
Biotechnology progress 2002;18(6):1287-91.
2002: Beata Gasowska; Hubert Wojtasek; Józef Hurek; Marcin Drag; Kornel Nowak; Pawel Kafarski
Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase.
European journal of biochemistry / FEBS 2002;269(16):4098-104.
2002: Michael B Martin; John M Sanders; Howard Kendrick; Kate de Luca-Fradley; Jared C Lewis; Joshua S Grimley; Erin M Van Brussel; Jeffrey R Olsen; Gary A Meints; Agnieszka Burzynska; Pawel Kafarski; Simon L Croft; Eric Oldfield
Activity of bisphosphonates against Trypanosoma brucei rhodesiense.
Journal of medicinal chemistry 2002;45(14):2904-14.
2002: Agnieszka Obojska; Nigel G Ternan; Barbara Lejczak; Pawel Kafarski; Geoff McMullan
Organophosphonate utilization by the thermophile Geobacillus caldoxylosilyticus T20.
Applied and environmental microbiology 2002;68(4):2081-4.
2001: Pawel Kafarski; Barbara Lejczak
Aminophosphonic acids of potential medical importance.
Current medicinal chemistry. Anti-cancer agents 2001;1(3):301-12.
2001: Z Ziora; Pawel Kafarski; Jolanta Holband; Grazyna Wójcik
Synthesis and spectroscopic characterization of protected N-phosphonomethylglycine dipeptides.
Journal of peptide science : an official publication of the European Peptide Society 2001;7(9):466-73.
2001: M Klimek; Barbara Lejczak; Pawel Kafarski; Giuseppe Forlani
Metabolism of the phosphonate herbicide glyphosate by a non-nitrate-utilizing strain of Penicillium chrysogenum.
Pest management science 2001;57(9):815-21.
2001: Jolanta Grembecka; Pawel Kafarski
Leucine aminopeptidase as a target for inhibitor design.
Mini reviews in medicinal chemistry 2001;1(2):133-44.
2001: Maciej Makowski; Malgorzata Pawelczak; R Latajka; K Nowak; Pawel Kafarski
Synthesis of tetrapeptide p-nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activity.
Journal of peptide science : an official publication of the European Peptide Society 2001;7(3):141-5.
2000: Pawel Dzygiel; E Rudzińska; Piotr P Wieczorek; Pawel Kafarski
Determination of optical purity of phosphonic acid analogues of aromatic amino acids by capillary electrophoresis with alpha-cyclodextrin.
Journal of chromatography. A 2000;895(1-2):301-7.
2000: Jolanta Grembecka; W Andrzej Sokalski; Pawel Kafarski
Computer-aided design and activity prediction of leucine aminopeptidase inhibitors.
Journal of computer-aided molecular design 2000;14(6):531-44.
1997: T Krzyśko-Lupicka; W Strof; K Kubś; M Skorupa; Piotr P Wieczorek; Barbara Lejczak; Pawel Kafarski
The ability of soil-borne fungi to degrade organophosphonate carbon-to-phosphorus bonds.
Applied microbiology and biotechnology 1997;48(4):549-52.