Valerian Kagan

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Phenomena

Oxidation-Reduction

Chemicals & Drugs

Procedures

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Publications

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Sengupta Rajib; Billiar Timothy R; Atkins James L; Kagan Valerian E; Stoyanovsky Detcho A
Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells.
Belikova Natalia A; Glumac Ashley; Rafikov Ruslan; Jiang Jianfei; Greenberger Joel S; Kagan Valerian E; Bayir Hülya
Radioprotection by short-term oxidative preconditioning: role of manganese superoxide dismutase.
Kagan Valerian E; Wipf Peter; Stoyanovsky Detcho; Greenberger Joel S; Borisenko Grigory; Belikova Natalia A; Yanamala Naveena; Samhan Arias Alejandro K; Tungekar Muhammad A; Jiang Jianfei; Tyurina Yulia Y; Ji Jing; Klein-Seetharaman Judith; Pitt Bruce R; Shvedova Anna A; Bayir Hülya
Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions.

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All Publications

2009: Sengupta Rajib; Billiar Timothy R; Atkins James L; Kagan Valerian E; Stoyanovsky Detcho A
Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells.
FEBS letters 2009;583(21):3525-30.
2009: Belikova Natalia A; Glumac Ashley; Rafikov Ruslan; Jiang Jianfei; Greenberger Joel S; Kagan Valerian E; Bayir Hülya
Radioprotection by short-term oxidative preconditioning: role of manganese superoxide dismutase.
FEBS letters 2009;583(21):3437-42.
2009: Kagan Valerian E; Wipf Peter; Stoyanovsky Detcho; Greenberger Joel S; Borisenko Grigory; Belikova Natalia A; Yanamala Naveena; Samhan Arias Alejandro K; Tungekar Muhammad A; Jiang Jianfei; Tyurina Yulia Y; Ji Jing; Klein-Seetharaman Judith; Pitt Bruce R; Shvedova Anna A; Bayir Hülya
Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions.
Advanced drug delivery reviews 2009;61(14):1375-85.
2009: Jiang Jianfei; McDonald Peter R; Dixon Tracy M; Franicola Darcy; Zhang Xichen; Nie Suhua; Epperly Laura D; Huang Zhentai; Kagan Valerian E; Lazo John S; Epperly Michael W; Greenberger Joel S
Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector.
Radiation research 2009;172(4):414-22.
2009: Kapralov Alexandr; Vlasova Irina I; Feng Weihong; Maeda Akihiro; Walson Karen; Tyurin Vladimir A; Huang Zhentai; Aneja Rajesh K; Carcillo Joseph; Bayir Hülya; Kagan Valerian E
Peroxidase activity of hemoglobin x haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages.
The Journal of biological chemistry 2009;284(44):30395-407.
2009: Rajagopalan Malolan S; Gupta Kanika; Epperly Michael W; Franicola Darcy; Zhang Xichen; Wang Hong; Zhao Hong; Tyurin Vladimir A; Pierce Joshua G; Kagan Valerian E; Wipf Peter; Kanai Anthony J; Greenberger Joel S
The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair.
In vivo (Athens, Greece) 2009;23(5):717-26.
2009: Sanmun Duangmanee; Witasp Erika; Jitkaew Siriporn; Tyurina Yulia Y; Kagan Valerian E; Ahlin Anders; Palmblad Jan; Fadeel Bengt
Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: implications for chronic granulomatous disease.
American journal of physiology. Cell physiology 2009;297(3):C621-31.
2009: Tyurin Vladimir A; Tyurina Yulia Y; Jung Mi-Yeon; Tungekar Muhammad A; Wasserloos Karla J; Bayir Hülya; Greenberger Joel S; Kochanek Patrick M; Shvedova Anna A; Pitt Bruce; Kagan Valerian E
Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2863-72.
2009: Belikova Natalia A; Tyurina Yulia Y; Borisenko Grigory; Tyurin Vladimir; Samhan Arias Alejandro K; Yanamala Naveena; Furtmüller Paul Georg; Klein-Seetharaman Judith; Obinger Christian; Kagan Valerian E
Heterolytic reduction of fatty acid hydroperoxides by cytochrome c/cardiolipin complexes: antioxidant function in mitochondria.
Journal of the American Chemical Society 2009;131(32):11288-9.
2009: Witasp Erika; Shvedova Anna A; Kagan Valerian E; Fadeel Bengt
Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses.
Inhalation toxicology 2009;21 Suppl 1():131-6.
2009: Belikova Natalia A; Jiang Jianfei; Stoyanovsky Detcho A; Glumac Ashley; Bayir Hülya; Greenberger Joel S; Kagan Valerian E
Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO(.) and protects mouse embryonic cells against irradiation-induced apoptosis.
FEBS letters 2009;583(12):1945-50.
2009: Bayir Hülya; Kapralov Alexandr A; Jiang Janfei; Huang Zhentai; Tyurina Yulia Y; Tyurin Vladimir A; Zhao Qing; Belikova Natalia A; Vlasova Irina I; Maeda Akihiro; Zhu Jianhui; Na Hye-Mee; Mastroberardino Pier-Giorgio; Sparvero Louis J; Amoscato Andrew A; Chu Charleen T; Greenamyre John T; Kagan Valerian E
Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease.
The Journal of biological chemistry 2009;284(23):15951-69.
2009: Kagan Valerian E; Bayir Hülya A; Belikova Natalia A; Kapralov Olexandr; Tyurina Yulia Y; Tyurin Vladimir A; Jiang Jianfei; Stoyanovsky Detcho A; Wipf Peter; Kochanek Patrick M; Greenberger Joel S; Pitt Bruce; Shvedova Anna A; Borisenko Grigory
Cytochrome c/cardiolipin relations in mitochondria: a kiss of death.
Free radical biology & medicine 2009;46(11):1439-53.
2009: Vladimirov Yu A; Proskurnina E V; Demin E M; Matveeva N S; Lubitskiy O B; Novikov A A; Izmailov D Yu; Osipov A N; Tikhonov V P; Kagan V E
Dihydroquercetin (taxifolin) and other flavonoids as inhibitors of free radical formation at key stages of apoptosis.
Biochemistry. Biokhimii?a 2009;74(3):301-7.
2009: Shurin Michael R; Potapovich Alla I; Tyurina Yulia Y; Tourkova Irina L; Shurin Galina V; Kagan Valerian E
Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer.
Cancer research 2009;69(6):2487-96.
2009: Murray A R; Kisin E; Leonard S S; Young S H; Kommineni C; Kagan V E; Castranova V; Shvedova A A
Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes.
Toxicology 2009;257(3):161-71.
2009: Jitkaew Siriporn; Witasp Erika; Zhang Shouting; Kagan Valerian E; Fadeel Bengt
Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: role in macrophage recognition and engulfment.
Journal of leukocyte biology 2009;85(3):427-37.
2009: Godoy Luiz C; Muñoz-Pinedo Cristina; Castro Laura; Cardaci Simone; Schonhoff Christopher M; King Michael; Tórtora Verónica; Marín Mónica; Miao Qian; Jiang Jian Fei; Kapralov Alexandr; Jemmerson Ronald; Silkstone Gary G; Patel Jinal N; Evans James E; Wilson Michael T; Green Douglas R; Kagan Valerian E; Radi Rafael; Mannick Joan B
Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2653-8.
2009: Bayir Hülya; Adelson P David; Wisniewski Stephen R; Shore Paul; Lai YiChen; Brown Danielle; Janesko-Feldman Keri L; Kagan Valerian E; Kochanek Patrick M
Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children.
Critical care medicine 2009;37(2):689-95.
2009: Shvedova A A; Kisin E R; Porter D; Schulte P; Kagan V E; Fadeel B; Castranova V
Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus?
Pharmacology & therapeutics 2009;121(2):192-204.
2009: Maki Richard A; Tyurin Vladimir A; Lyon Robert C; Hamilton Ronald L; DeKosky Steven T; Kagan Valerian E; Reynolds Wanda F
Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease.
The Journal of biological chemistry 2009;284(5):3158-69.
2009: Du Lina; Hickey Robert W; Bayir Hülya; Watkins Simon C; Tyurin Vladimir A; Guo Fengli; Kochanek Patrick M; Jenkins Larry W; Ren Jin; Gibson Greg; Chu Charleen T; Kagan Valerian E; Clark Robert S B
Starving neurons show sex difference in autophagy.
The Journal of biological chemistry 2009;284(4):2383-96.
2009: Kagan Valerian E; Bayir Ayse; Bayir Hulya; Stoyanovsky Detcho; Borisenko Grigory G; Tyurina Yulia Y; Wipf Peter; Atkinson Jeffrey; Greenberger Joel S; Chapkin Robert S; Belikova Natalia A
Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery.
Molecular nutrition & food research 2009;53(1):104-14.
2009: Tyurina Yulia Y; Tyurin Vladimir A; Kapralova Valentina I; Amoscato Andrew A; Epperly Michael W; Greenberger Joel S; Kagan Valerian E
Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation.
Methods in molecular biology (Clifton, N.J.) 2009;580():153-83.
2009: Konduru Nagarjun V; Tyurina Yulia Y; Feng Weihong; Basova Liana V; Belikova Natalia A; Bayir Hülya; Clark Katherine; Rubin Marc; Stolz Donna; Vallhov Helen; Scheynius Annika; Witasp Erika; Fadeel Bengt; Kichambare Padmakar D; Star Alexander; Kisin Elena R; Murray Ashley R; Shvedova Anna A; Kagan Valerian E
Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo.
PloS one 2009;4(2):e4398.
2008: Allen Brett L; Kichambare Padmakar D; Gou Pingping; Vlasova Irina I; Kapralov Alexander A; Konduru Nagarjun; Kagan Valerian E; Star Alexander
Biodegradation of single-walled carbon nanotubes through enzymatic catalysis.
Nano letters 2008;8(11):3899-903.
2008: Shvedova A A; Kisin E; Murray A R; Johnson V J; Gorelik O; Arepalli S; Hubbs A F; Mercer R R; Keohavong P; Sussman N; Jin J; Yin J; Stone S; Chen B T; Deye G; Maynard A; Castranova V; Baron P A; Kagan V E
Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis.
American journal of physiology. Lung cellular and molecular physiology 2008;295(4):L552-65.
2008: Shvedova A A; Kisin E R; Murray A R; Kommineni C; Castranova V; Fadeel B; Kagan V E
Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes.
Toxicology and applied pharmacology 2008;231(2):235-40.
2008: Gandley Robin E; Rohland Jennifer; Zhou Yan; Shibata Eiji; Harger Gail F; Rajakumar Augustine; Kagan Valerian E; Markovic Nina; Hubel Carl A
Increased myeloperoxidase in the placenta and circulation of women with preeclampsia.
Hypertension 2008;52(2):387-93.
2008: Huang Zhentai; Jiang Jianfei; Tyurin Vladimir A; Zhao Qing; Mnuskin Alexandra; Ren Jin; Belikova Natalia A; Feng Weihong; Kurnikov Igor V; Kagan Valerian E
Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis.
Free radical biology & medicine 2008;44(11):1935-44.
2008: Shvedova Anna A; Fabisiak James P; Kisin Elena R; Murray Ashley R; Roberts Jenny R; Tyurina Yulia Y; Antonini James M; Feng Wei Hong; Kommineni Choudari; Reynolds Jeffrey; Barchowsky Aaron; Castranova Vince; Kagan Valerian E
Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity.
American journal of respiratory cell and molecular biology 2008;38(5):579-90.
2008: Jiang Jianfei; Belikova Natalia A; Hoye Adam T; Zhao Qing; Epperly Michael W; Greenberger Joel S; Wipf Peter; Kagan Valerian E
A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation.
International journal of radiation oncology, biology, physics 2008;70(3):816-25.
2008: Stoyanovsky Detcho A; Vlasova Irina I; Belikova Natalia A; Kapralov Alexandr; Tyurin Vladimir; Greenberger Joel S; Kagan Valerian E
Activation of NO donors in mitochondria: peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis.
FEBS letters 2008;582(5):725-8.
2008: Jiang Jianfei; Huang Zhentai; Zhao Qing; Feng Weihong; Belikova Natalia A; Kagan Valerian E
Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis.
Biochemical and biophysical research communications 2008;368(1):145-50.
2008: Tyurina Yulia Y; Tyurin Vladimir A; Epperly Michael W; Greenberger Joel S; Kagan Valerian E
Oxidative lipidomics of gamma-irradiation-induced intestinal injury.
Free radical biology & medicine 2008;44(3):299-314.
2008: Hoye Adam T; Davoren Jennifer E; Wipf Peter; Fink Mitchell P; Kagan Valerian E
Targeting mitochondria.
Accounts of chemical research 2008;41(1):87-97.
2008: Tyurin Vladimir A; Tyurina Yulia Y; Kochanek Patrick M; Hamilton Ronald; DeKosky Steven T; Greenberger Joel S; Bayir Hülya; Kagan Valerian E
Oxidative lipidomics of programmed cell death.
Methods in enzymology 2008;442():375-93.
2008: Bayir Hülya; Kagan Valerian E
Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis--there is nothing more practical than a good theory.
Critical care (London, England) 2008;12(1):206.
2007: Kisin Elena R; Murray Ashley R; Keane Michael J; Shi Xiao-Chun; Schwegler-Berry Diane; Gorelik Olga; Arepalli Sivaram; Castranova Vincent; Wallace William E; Kagan Valerian E; Shvedova Anna A
Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells.
Journal of toxicology and environmental health. Part A 2007;70(24):2071-9.
2007: Kapralov Alexander A; Kurnikov Igor V; Vlasova Irina I; Belikova Natalia A; Tyurin Vladimir A; Basova Liana V; Zhao Quing; Tyurina Yulia Y; Jiang Jianfei; Bayir Hulya; Vladimirov Yuri A; Kagan Valerian E
The hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells.
Biochemistry 2007;46(49):14232-44.
2007: Fink Mitchell P; Macias Carlos A; Xiao Jingbo; Tyurina Yulia Y; Delude Russell L; Greenberger Joel S; Kagan Valerian E; Wipf Peter
Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants.
Critical care medicine 2007;35(9 Suppl):S461-7.
2007: Belikova Natalia A; Jiang Jianfei; Tyurina Yulia Y; Zhao Qing; Epperly Michael W; Greenberger Joel; Kagan Valerian E
Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis.
International journal of radiation oncology, biology, physics 2007;69(1):176-86.
2007: Fink Mitchell P; Macias Carlos A; Xiao Jingbo; Tyurina Yulia Y; Jiang Jianfei; Belikova Natalia; Delude Russell L; Greenberger Joel S; Kagan Valerian E; Wipf Peter
Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants.
Biochemical pharmacology 2007;74(6):801-9.
2007: Bayir Hülya; Tyurin Vladimir A; Tyurina Yulia Y; Viner Rosa; Ritov Vladimir; Amoscato Andrew A; Zhao Qing; Zhang Xiaojing J; Janesko-Feldman Keri L; Alexander Henry; Basova Liana V; Clark Robert S B; Kochanek Patrick M; Kagan Valerian E
Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis.
Annals of neurology 2007;62(2):154-69.
2007: Kagan Valerian E; Jiang Jianfei; Bayir Hülya; Stoyanovsky Detcho A
Targeting nitroxides to mitochondria: location, location, location, and ...concentration: highlight commentary on "Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide".
Free radical biology & medicine 2007;43(3):348-50.
2007: Shvedova Anna A; Kisin Elena R; Murray Ashley R; Gorelik Olga; Arepalli Sivaram; Castranova Vincent; Young Shih-Hong; Gao Fei; Tyurina Yulia Y; Oury Tim D; Kagan Valerian E
Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice.
Toxicology and applied pharmacology 2007;221(3):339-48.
2007: Bayir Hülya; Kagan Valerian E; Clark Robert S B; Janesko-Feldman Keri; Rafikov Ruslan; Huang Zhentai; Zhang Xiaojing; Vagni Vincent; Billiar Timothy R; Kochanek Patrick M
Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.
Journal of neurochemistry 2007;101(1):168-81.
2007: Tyurin V A; Tyurina Y Y; Osipov A N; Belikova N A; Basova L V; Kapralov A A; Bayir H; Kagan V E
Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis.
Cell death and differentiation 2007;14(4):872-5.
2007: Basova Liana V; Kurnikov Igor V; Wang Lei; Ritov Vladimir B; Belikova Natalia A; Vlasova Irina I; Pacheco Andy A; Winnica Daniel E; Peterson Jim; Bayir Hülya; Waldeck David H; Kagan Valerian E
Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity.
Biochemistry 2007;46(11):3423-34.
2007: Tyurina Yulia Y; Basova Liana V; Konduru Nagarjun V; Tyurin Vladimir A; Potapovich Ala I; Cai Peter; Bayir Hülya; Stoyanovsky Detcho; Pitt Bruce R; Shvedova Anna A; Fadeel Bengt; Kagan Valerian E
Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation.
The Journal of biological chemistry 2007;282(11):8498-509.
2007: Jiang Jianfei; Kurnikov Igor; Belikova Natalia A; Xiao Jingbo; Zhao Qing; Amoscato Andrew A; Braslau Rebecca; Studer Armido; Fink Mitchell P; Greenberger Joel S; Wipf Peter; Kagan Valerian E
Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides.
The Journal of pharmacology and experimental therapeutics 2007;320(3):1050-60.
2007: Macias Carlos A; Chiao Jeffrey W; Xiao Jingbo; Arora Devinder S; Tyurina Yulia Y; Delude Russell L; Wipf Peter; Kagan Valerian E; Fink Mitchell P
Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock.
Annals of surgery 2007;245(2):305-14.
2006: Costacou Tina; Zgibor Janice C; Evans Rhobert W; Tyurina Yulia Y; Kagan Valerian E; Orchard Trevor J
Antioxidants and coronary artery disease among individuals with type 1 diabetes: Findings from the Pittsburgh Epidemiology of Diabetes Complications Study.
Journal of diabetes and its complications 2006;20(6):387-94.
2006: Osipov A N; Stepanov G O; Vladimirov Yu A; Kozlov A V; Kagan V E
Regulation of cytochrome C peroxidase activity by nitric oxide and laser irradiation.
Biochemistry. Biokhimii?a 2006;71(10):1128-32.
2006: Zhang Li-Ming; St Croix Claudette; Cao Rong; Wasserloos Karla; Watkins Simon C; Stevens Troy; Li Song; Tyurin Vladimir; Kagan Valerian E; Pitt Bruce R
Cell-surface protein disulfide isomerase is required for transnitrosation of metallothionein by S-nitroso-albumin in intact rat pulmonary vascular endothelial cells.
Experimental biology and medicine (Maywood, N.J.) 2006;231(9):1507-15.
2006: Kagan V E; Tyurina Y Y; Bayir H; Chu C T; Kapralov A A; Vlasova I I; Belikova N A; Tyurin V A; Amoscato A; Epperly M; Greenberger J; Dekosky S; Shvedova A A; Jiang J
The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes.
Chemico-biological interactions 2006;163(1-2):15-28.
2006: Vladimirov Yu A; Proskurnina E V; Izmailov D Yu; Novikov A A; Brusnichkin A V; Osipov A N; Kagan V E
Cardiolipin activates cytochrome c peroxidase activity since it facilitates H(2)O(2) access to heme.
Biochemistry. Biokhimii?a 2006;71(9):998-1005.
2006: Vladimirov Yu A; Proskurnina E V; Izmailov D Yu; Novikov A A; Brusnichkin A V; Osipov A N; Kagan V E
Mechanism of activation of cytochrome C peroxidase activity by cardiolipin.
Biochemistry. Biokhimii?a 2006;71(9):989-97.
2006: Tyurina Yulia Y; Kini Vidisha; Tyurin Vladimir A; Vlasova Irina I; Jiang Jianfei; Kapralov Alexander A; Belikova Natalia A; Yalowich Jack C; Kurnikov Igor V; Kagan Valerian E
Mechanisms of cardiolipin oxidation by cytochrome c: relevance to pro- and antiapoptotic functions of etoposide.
Molecular pharmacology 2006;70(2):706-17.
2006: Kagan V E; Tyurina Y Y; Tyurin V A; Konduru N V; Potapovich A I; Osipov A N; Kisin E R; Schwegler-Berry D; Mercer R; Castranova V; Shvedova A A
Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron.
Toxicology letters 2006;165(1):88-100.
2006: Tyurina Yulia Y; Kapralov Alexander A; Jiang Jianfei; Borisenko Grigory G; Potapovich Alla I; Sorokin Andrey; Kochanek Patrick M; Graham Steven H; Schor Nina F; Kagan Valerian E
Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells.
Brain research 2006;1093(1):71-82.
2006: Bayir H; Fadeel B; Palladino M J; Witasp E; Kurnikov I V; Tyurina Y Y; Tyurin V A; Amoscato A A; Jiang J; Kochanek P M; DeKosky S T; Greenberger J S; Shvedova A A; Kagan V E
Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria.
Biochimica et biophysica acta 2006;1757(5-6):648-59.
2006: Vlasova Irina I; Tyurin Vladimir A; Kapralov Alexandr A; Kurnikov Igor V; Osipov Anatoly N; Potapovich Maxim V; Stoyanovsky Detcho A; Kagan Valerian E
Nitric oxide inhibits peroxidase activity of cytochrome c.cardiolipin complex and blocks cardiolipin oxidation.
The Journal of biological chemistry 2006;281(21):14554-62.
2006: Belikova Natalia A; Vladimirov Yury A; Osipov Anatoly N; Kapralov Alexandr A; Tyurin Vladimir A; Potapovich Maksim V; Basova Liana V; Peterson Jim; Kurnikov Igor V; Kagan Valerian E
Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes.
Biochemistry 2006;45(15):4998-5009.
2006: Ramirez Rolando J J; Hubel Carl A; Novak Jacqueline; DiCianno Jennifer R; Kagan Valerian E; Gandley Robin E
Moderate ascorbate deficiency increases myogenic tone of arteries from pregnant but not virgin ascorbate-dependent rats.
Hypertension 2006;47(3):454-60.
2006: Gong Haibiao; Singh Shivendra V; Singh Sharda P; Mu Ying; Lee Jung Hoon; Saini Simrat P S; Toma David; Ren Songrong; Kagan Valerian E; Day Billy W; Zimniak Piotr; Xie Wen
Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells.
Molecular endocrinology (Baltimore, Md.) 2006;20(2):279-90.
2006: Mi Zhiping; Hong Borah; Mirnics Zeljka Korade; Tyurina Yulia Y; Kagan Valerian E; Liang Ye; Schor Nina Felice
Bcl-2-mediated potentiation of neocarzinostatin-induced apoptosis: requirement for caspase-3, sulfhydryl groups, and cleavable Bcl-2.
Cancer chemotherapy and pharmacology 2006;57(3):357-67.
2006: Yishak Aklilu A; Costacou Tina; Virella Gabriel; Zgibor Janice; Fried Linda; Walsh Michael; Evans Rhobert W; Lopes-Virella Maria; Kagan Valerian E; Otvos James; Orchard Trevor J
Novel predictors of overt nephropathy in subjects with type 1 diabetes. A nested case control study from the Pittsburgh Epidemiology of Diabetes Complications cohort.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(1):93-100.
2006: Bayir Hülya; Kochanek Patrick M; Kagan Valerian E
Oxidative stress in immature brain after traumatic brain injury.
Developmental neuroscience 2006;28(4-5):420-31.
2005: Kagan Valerian E; Bayir Hülya; Shvedova Anna A
Nanomedicine and nanotoxicology: two sides of the same coin.
Nanomedicine : nanotechnology, biology, and medicine 2005;1(4):313-6.
2005: Stoyanovsky Detcho A; Tyurina Yulia Y; Tyurin Vladimir A; Anand Deepthi; Mandavia Dhara N; Gius David; Ivanova Juliana; Pitt Bruce; Billiar Timothy R; Kagan Valerian E
Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols.
Journal of the American Chemical Society 2005;127(45):15815-23.
2005: Liang Qinghua; Smith Amanda D; Pan Stephen; Tyurin Vladimir A; Kagan Valerian E; Hastings Teresa G; Schor Nina Felice
Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease.
Biochemical pharmacology 2005;70(9):1371-81.
2005: Shvedova Anna A; Kisin Elena R; Mercer Robert; Murray Ashley R; Johnson Victor J; Potapovich Alla I; Tyurina Yulia Y; Gorelik Olga; Arepalli Sevaram; Schwegler-Berry Diane; Hubbs Ann F; Antonini James; Evans Douglas E; Ku Bon-Ki; Ramsey Dawn; Maynard Andrew; Kagan Valerian E; Castranova Vincent; Baron Paul
Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice.
American journal of physiology. Lung cellular and molecular physiology 2005;289(5):L698-708.
2005: Kagan Valerian E; Tyurin Vladimir A; Jiang Jianfei; Tyurina Yulia Y; Ritov Vladimir B; Amoscato Andrew A; Osipov Anatoly N; Belikova Natalia A; Kapralov Alexandr A; Kini Vidisha; Vlasova Irina I; Zhao Qing; Zou Meimei; Di Peter; Svistunenko Dimitry A; Kurnikov Igor V; Borisenko Gregory G
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors.
Nature chemical biology 2005;1(4):223-32.
2005: Wipf Peter; Xiao Jingbo; Jiang Jianfei; Belikova Natalia A; Tyurin Vladimir A; Fink Mitchell P; Kagan Valerian E
Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates.
Journal of the American Chemical Society 2005;127(36):12460-1.
2005: Tyurina Yulia Y; Nylander Karen D; Mirnics Zeljka Korade; Portugal Carmel; Yan Chaohua; Zaccaro Clara; Saragovi H Uri; Kagan Valerian E; Schor Nina F
The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress.
Aging cell 2005;4(4):187-96.
2005: Serinkan B F; Gambelli F; Potapovich A I; Babu H; Di Giuseppe M; Ortiz L A; Fabisiak J P; Kagan V E
Apoptotic cells quench reactive oxygen and nitrogen species and modulate TNF-alpha/TGF-beta1 balance in activated macrophages: involvement of phosphatidylserine-dependent and -independent pathways.
Cell death and differentiation 2005;12(8):1141-4.
2005: Bayir Hülya; Kagan Valerian E; Borisenko Grigory G; Tyurina Yulia Y; Janesko Keri L; Vagni Vincent A; Billiar Timothy R; Williams Deborah L; Kochanek Patrick M
Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(6):673-84.
2005: Heck Diane E; Kagan Valerian E; Shvedova Anna A; Laskin Jeffrey D
An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis.
Toxicology 2005;208(2):259-71.
2005: Gandley Robin E; Tyurin Vladimir A; Huang Wan; Arroyo Antonio; Daftary Ashi; Harger Gail; Jiang Jianfei; Pitt Bruce; Taylor Robert N; Hubel Carl A; Kagan Valerian E
S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma.
Hypertension 2005;45(1):21-7.
2005: St Croix Claudette M; Leelavaninchkul Karanee; Watkins Simon C; Kagan Valerian E; Pitt Bruce R
Nitric oxide and zinc homeostasis in acute lung injury.
Proceedings of the American Thoracic Society 2005;2(3):236-42.
2005: Fabisiak James P; Borisenko Grigory G; Kagan Valerian E
Quantitative method of measuring phosphatidylserine externalization during apoptosis using electron paramagnetic resonance spectroscopy and annexin-conjugated iron.
Methods in molecular biology (Clifton, N.J.) 2005;291():457-64.
2005: Fabisiak James P; Tyurina Yulia Y; Tyurin Vladimir A; Kagan Valerian E
Quantification of selective phosphatidylserine oxidation during apoptosis.
Methods in molecular biology (Clifton, N.J.) 2005;291():449-56.
2004: Kagan Valerian E; Borisenko Grigory G; Tyurina Yulia Y; Tyurin Vladimir A; Jiang Jianfei; Potapovich Alla I; Kini Vidisha; Amoscato Andrew A; Fujii Yasu
Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine.
Free radical biology & medicine 2004;37(12):1963-85.
2004: Jiang Jianfei; Kini Vidisha; Belikova Natalia; Serinkan Behice F; Borisenko Grigory G; Tyurina Yulia Y; Tyurin Vladimir A; Kagan Valerian E
Cytochrome c release is required for phosphatidylserine peroxidation during Fas-triggered apoptosis in lung epithelial A549 cells.
Lipids 2004;39(11):1133-42.
2004: Tyurina Yulia Y; Tyurin Vladimir A; Zhao Qing; Djukic Mirjana; Quinn Peter J; Pitt Bruce R; Kagan Valerian E
Oxidation of phosphatidylserine: a mechanism for plasma membrane phospholipid scrambling during apoptosis?
Biochemical and biophysical research communications 2004;324(3):1059-64.
2004: Jiang Jianfei; Borisenko Grigory G; Osipov Anatoly; Martin Ian; Chen Renwu; Shvedova Anna A; Sorokin Andrey; Tyurina Yulia Y; Potapovich Alla; Tyurin Vladimir A; Graham Steven H; Kagan Valerian E
Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cells.
Journal of neurochemistry 2004;90(5):1036-49.
2004: Borisenko Grigory G; Martin Ian; Zhao Qing; Amoscato Andrew A; Kagan Valerian E
Nitroxides scavenge myeloperoxidase-catalyzed thiyl radicals in model systems and in cells.
Journal of the American Chemical Society 2004;126(30):9221-32.
2004: Weinberg Ariella; Nylander Karen D; Yan Chaohua; Ma Li; Hsia Carleton J C; Tyurin Vladimir A; Kagan Valerian E; Schor Nina F
Prevention of catecholaminergic oxidative toxicity by 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl and its recycling complex with polynitroxylated albumin, TEMPOL/PNA.
Brain research 2004;1012(1-2):13-21.
2004: Matsura Tatsuya; Kai Masachika; Jiang Jianfei; Babu Hareesh; Kini Vidisha; Kusumoto Chiaki; Yamada Kazuo; Kagan Valerian E
Endogenously generated hydrogen peroxide is required for execution of melphalan-induced apoptosis as well as oxidation and externalization of phosphatidylserine.
Chemical research in toxicology 2004;17(5):685-96.
2004: Borisenko Grigory G; Martin Ian; Zhao Qing; Amoscato Andrew A; Tyurina Yulia Y; Kagan Valerian E
Glutathione propagates oxidative stress triggered by myeloperoxidase in HL-60 cells. Evidence for glutathionyl radical-induced peroxidation of phospholipids and cytotoxicity.
The Journal of biological chemistry 2004;279(22):23453-62.
2004: Serinkan Behice F; Tyurina Yulia Y; Babu Hareesh; Djukic Mirjana; Quinn Peter J; Schroit Alan; Kagan Valerian E
Vitamin E inhibits anti-Fas-induced phosphatidylserine oxidation but does not affect its externalization during apoptosis in Jurkat T cells and their phagocytosis by J774A.1 macrophages.
Antioxidants & redox signaling 2004;6(2):227-36.
2004: Tyurina Yulia Y; Kawai Kazuaki; Tyurin Vladimir A; Liu Shang-Xi; Kagan Valerian E; Fabisiak James P
The plasma membrane is the site of selective phosphatidylserine oxidation during apoptosis: role of cytochrome C.
Antioxidants & redox signaling 2004;6(2):209-25.
2004: Forsberg A Johanna; Kagan Valerian E; Schroit Alan J
Thiol oxidation enforces phosphatidylserine externalization in apoptosis-sensitive and -resistant cells through a deltapsim/cytochrome C release-dependent mechanism.
Antioxidants & redox signaling 2004;6(2):203-8.
2004: Kagan Valerian E; Quinn Peter J
Toward oxidative lipidomics of cell signaling.
Antioxidants & redox signaling 2004;6(2):199-202.
2004: Epperly Michael W; Osipov Anatoli N; Martin Ian; Kawai Kazuaki K; Borisenko Grigory G; Tyurina Yulia Y; Jefferson Mia; Bernarding Michael; Greenberger Joel S; Kagan Valerian E
Ascorbate as a "redox sensor" and protector against irradiation-induced oxidative stress in 32D CL 3 hematopoietic cells and subclones overexpressing human manganese superoxide dismutase.
International journal of radiation oncology, biology, physics 2004;58(3):851-61.
2004: Tyurina Yulia Y; Serinkan F Behice; Tyurin Vladimir A; Kini Vidisha; Yalowich Jack C; Schroit Alan J; Fadeel Bengt; Kagan Valerian E
Lipid antioxidant, etoposide, inhibits phosphatidylserine externalization and macrophage clearance of apoptotic cells by preventing phosphatidylserine oxidation.
The Journal of biological chemistry 2004;279(7):6056-64.
2004: Schor N F; Kagan V E; Liang Ye; Yan Ch; Tyurina Yu; Tyurin V; Nylander K D
Exploiting oxidative stress and signaling in chemotherapy of resistant neoplasms.
Biochemistry. Biokhimii?a 2004;69(1):38-44.
2003: Jiang Jianfei; Serinkan Behice F; Tyurina Yulia Y; Borisenko Grigory G; Mi Zhibao; Robbins Paul D; Schroit Alan J; Kagan Valerian E
Peroxidation and externalization of phosphatidylserine associated with release of cytochrome c from mitochondria.
Free radical biology & medicine 2003;35(7):814-25.
2003: Ray Prabir; Chen Li; Tyurin Vladimir A; Kagan Valerian E; Witzmann Frank A
Proteomic and inducible transgenic approaches to study disease processes.
American journal of respiratory cell and molecular biology 2003;29(3 Suppl):S42-6.
2003: Kagan V E; Borisenko G G; Serinkan B F; Tyurina Y Y; Tyurin V A; Jiang J; Liu S X; Shvedova A A; Fabisiak J P; Uthaisang W; Fadeel B
Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine.
American journal of physiology. Lung cellular and molecular physiology 2003;285(1):L1-17.
2003: Greenberger J S; Epperly M W; Gretton J; Jefferson M; Nie S; Bernarding M; Kagan V; Guo H L
Radioprotective gene therapy.
Current gene therapy 2003;3(3):183-95.
2003: Bello Rosario I; Kagan Valerian E; Tyurin Vladimir; Navarro Francisco; Alcaín Francisco J; Villalba José M
Regeneration of lipophilic antioxidants by NAD(P)H:quinone oxidoreductase 1.
Protoplasma 2003;221(1-2):129-35.
2003: Gryzunov Y A; Arroyo A; Vigne J-L; Zhao Q; Tyurin V A; Hubel C A; Gandley R E; Vladimirov Y A; Taylor R N; Kagan V E
Binding of fatty acids facilitates oxidation of cysteine-34 and converts copper-albumin complexes from antioxidants to prooxidants.
Archives of biochemistry and biophysics 2003;413(1):53-66.
2003: Borisenko Grigory G; Matsura Tatsuya; Liu Shang-Xi; Tyurin Vladimir A; Jianfei Jiang; Serinkan Fatma B; Kagan Valerian E
Macrophage recognition of externalized phosphatidylserine and phagocytosis of apoptotic Jurkat cells--existence of a threshold.
Archives of biochemistry and biophysics 2003;413(1):41-52.
2003: Kagan V E; Kuzmenko A I; Shvedova A A; Kisin E R; Li R; Martin I; Quinn P J; Tyurin V A; Tyurina Y Y; Yalowich J C
Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells.
Biochimica et biophysica acta 2003;1620(1-3):72-84.
2003: Bayir Hülya; Kochanek Patrick M; Liu Shang-Xi; Arroyo Antonio; Osipov Anatoly; Jiang Jianfei; Wisniewski Stephan; Adelson P David; Graham Steven H; Kagan Valerian E
Increased S-nitrosothiols and S-nitrosoalbumin in cerebrospinal fluid after severe traumatic brain injury in infants and children: indirect association with intracranial pressure.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(1):51-61.
2003: Fadeel Bengt; Kagan Valerian E
Apoptosis and macrophage clearance of neutrophils: regulation by reactive oxygen species.
Redox report : communications in free radical research 2003;8(3):143-50.
2002: Ritov Vladimir B; Kelley David E; Kagan Valerian E
Derivatization of F2-isoprostanes with 1-pyrenyldiazomethane and their subsequent determination by fluorescence high-performance liquid chromatography.
Analytical biochemistry 2002;311(1):10-8.
2002: Arroyo Antonio; Modrianský Martin; Serinkan F Behice; Bello Rosario I; Matsura Tatsuya; Jiang Jianfei; Tyurin Vladimir A; Tyurina Yulia Y; Fadeel Bengt; Kagan Valerian E
NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells. Role in phagocytic clearance.
The Journal of biological chemistry 2002;277(51):49965-75.
2002: Kentner Rainer; Safar Peter; Behringer Wilhelm; Wu Xianren; Kagan Valerian E; Tyurina Yulia Y; Henchir Jeremy; Ma Li; Hsia Carleton J C; Tisherman Samuel A
Early antioxidant therapy with Tempol during hemorrhagic shock increases survival in rats.
The Journal of trauma 2002;53(5):968-77.
2002: Fabisiak James P; Sedlov Andrey; Kagan Valerian E
Quantification of oxidative/nitrosative modification of CYS(34) in human serum albumin using a fluorescence-based SDS-PAGE assay.
Antioxidants & redox signaling 2002;4(5):855-65.
2002: Elsayed Nabil M; Gorbunov Nikolai V; Mayorga Maria A; Kagan Valerian E; Januszkiewicz Adolph J
Significant pulmonary response to a brief high-level, nose-only nitrogen dioxide exposure: an interspecies dosimetry perspective.
Toxicology and applied pharmacology 2002;184(1):1-10.
2002: Hubel Carl A; Kagan Valerian E; Roberts James M
8,12-iso-iPF(2alpha)-VI: the last word on oxidative stress?
American journal of obstetrics and gynecology 2002;187(4):1119; author reply 1119-20.
2002: Jiang Jianfei; St Croix Claudette M; Sussman Nancy; Zhao Qing; Pitt Bruce R; Kagan Valerian E
Contribution of glutathione and metallothioneins to protection against copper toxicity and redox cycling: quantitative analysis using MT+/+ and MT-/- mouse lung fibroblast cells.
Chemical research in toxicology 2002;15(8):1080-7.
2002: Modriansky Martin; Tyurina Yulia Y; Tyurin Vladimir A; Matsura Tatsuya; Shvedova Anna A; Yalowich Jack C; Kagan Valerian E
Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?
Toxicology 2002;177(1):105-17.
2002: Matsura Tatsuya; Serinkan Behice F; Jiang Jianfei; Kagan Valerian E
Phosphatidylserine peroxidation/externalization during staurosporine-induced apoptosis in HL-60 cells.
FEBS letters 2002;524(1-3):25-30.
2002: Kagan Valerian E; Gleiss Bettina; Tyurina Yulia Y; Tyurin Vladimir A; Elenström-Magnusson Carina; Liu Shang-Xi; Serinkan F Behice; Arroyo Antonio; Chandra Joya; Orrenius Sten; Fadeel Bengt
A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):487-99.
2002: Shvedova Anna A; Tyurina Julia Y; Kawai Kazuaki; Tyurin Vladimir A; Kommineni Choudari; Castranova Vincent; Fabisiak James P; Kagan Valerian E
Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide.
The Journal of investigative dermatology 2002;118(6):1008-18.
2002: Koty Patrick P; Tyurina Yulia Y; Tyurin Vladimir A; Li Shang-Xi; Kagan Valerian E
Depletion of Bcl-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells.
Molecular and cellular biochemistry 2002;234-235(1-2):125-33.
2002: Bayir Hulya; Kagan Valerian E; Tyurina Yulia Y; Tyurin Vladimir; Ruppel Randall A; Adelson P David; Graham Steven H; Janesko Keri; Clark Robert S B; Kochanek Patrick M
Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children.
Pediatric research 2002;51(5):571-8.
2002: Kagan Valerian E; Kisin Elena R; Kawai Kazuaki; Serinkan Behice F; Osipov Anatoly N; Serbinova Elena A; Wolinsky Ira; Shvedova Anna A
Toward mechanism-based antioxidant interventions: lessons from natural antioxidants.
Annals of the New York Academy of Sciences 2002;959():188-98.
2002: Behringer Wilhelm; Safar Peter; Kentner Rainer; Wu Xianren; Kagan Valerian E; Radovsky Ann; Clark Robert S B; Kochanek Patrick M; Subramanian Murugan; Tyurin Vladimir A; Tyurina Yulia Y; Tisherman Samuel A
Antioxidant Tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(1):105-17.
2002: Tyurin Vladimir A; Tyurina Yulia Y; Liu Shang-Xi; Bayir Hülya; Hubel Carl A; Kagan Valerian E
Quantitation of S-nitrosothiols in cells and biological fluids.
Methods in enzymology 2002;352():347-60.
2002: Tyurina Yulia Y; Tyurin Vladimir A; Shvedova Anna A; Fabisiak James P; Kagan Valerian E
Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling.
Methods in enzymology 2002;352():159-74.
2002: Fabisiak James P; Borisenko Gregory G; Liu Shang-Xi; Tyurin Vladimir A; Pitt Bruce R; Kagan Valerian E
Redox sensor function of metallothioneins.
Methods in enzymology 2002;353():268-81.
2002: Tyurina Y Y; Tyurin V A; Liu S X; Smith C A; Shvedova A A; Schor N F; Kagan V E
Phosphatidylserine peroxidation during apoptosis. A signaling pathway for phagocyte clearance.
Sub-cellular biochemistry 2002;36():79-96.
2001: Kagan V E; Kuzmenko A I; Tyurina Y Y; Shvedova A A; Matsura T; Yalowich J C
Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase.
Cancer research 2001;61(21):7777-84.
2001: Epperly M W; Kagan V E; Sikora C A; Gretton J E; Defilippi S J; Bar-Sagi D; Greenberger J S
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation.
International journal of cancer. Journal international du cancer 2001;96(4):221-31.
2001: Greenberger J S; Kagan V E; Pearce L; Boriseniao G; Tyurina Y; Epperly M W
Modulation of redox signal transduction pathways in the treatment of cancer.
Antioxidants & redox signaling 2001;3(3):347-59.
2001: Tyurin V A; Liu S X; Tyurina Y Y; Sussman N B; Hubel C A; Roberts J M; Taylor R N; Kagan V E
Elevated levels of S-nitrosoalbumin in preeclampsia plasma.
Circulation research 2001;88(11):1210-5.
2001: Kagan V E; Kozlov A V; Tyurina Y Y; Shvedova A A; Yalowich J C
Antioxidant mechanisms of nitric oxide against iron-catalyzed oxidative stress in cells.
Antioxidants & redox signaling 2001;3(2):189-202.
2001: Liu S; Kawai K; Tyurin V A; Tyurina Y Y; Borisenko G G; Fabisiak J P; Quinn P J; Pitt B R; Kagan V E
Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate.
The Biochemical journal 2001;354(Pt 2):397-406.
2001: Shvedova A A; Tyurina Y Y; Tyurin V A; Kikuchi Y; Kagan V E; Quinn P J
Quantitative analysis of phospholipid peroxidation and antioxidant protection in live human epidermal keratinocytes.
Bioscience reports 2001;21(1):33-43.
2001: Kagan V E; Tyurin V A; Borisenko G G; Fabisiak J P; Hubel C A; Ness R B; Gandley R; McLaughlin M K; Roberts J M
Mishandling of copper by albumin: role in redox-cycling and oxidative stress in preeclampsia plasma.
Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy 2001;20(3):221-41.
2000: Vladimirov Y A; Arroyo A; Taylor J M; Tyurina Y Y; Matsura T; Tyurin V A; Kagan V E
Quinolizin-coumarins as physical enhancers of chemiluminescence during lipid peroxidation in live HL-60 cells.
Archives of biochemistry and biophysics 2000;384(1):154-62.
2000: Kawai K; Liu S X; Tyurin V A; Tyurina Y Y; Borisenko G G; Jiang J F; St Croix C M; Fabisiak J P; Pitt B R; Kagan V E
Antioxidant and antiapoptotic function of metallothioneins in HL-60 cells challenged with copper nitrilotriacetate.
Chemical research in toxicology 2000;13(12):1275-86.
2000: Tyurin V A; Tyurina Y Y; Borisenko G G; Sokolova T V; Ritov V B; Quinn P J; Rose M; Kochanek P; Graham S H; Kagan V E
Oxidative stress following traumatic brain injury in rats: quantitation of biomarkers and detection of free radical intermediates.
Journal of neurochemistry 2000;75(5):2178-89.
2000: Liu S X; Fabisiak J P; Tyurin V A; Borisenko G G; Pitt B R; Lazo J S; Kagan V E
Reconstitution of apo-superoxide dismutase by nitric oxide-induced copper transfer from metallothioneins.
Chemical research in toxicology 2000;13(9):922-31.
2000: Tyurina Y Y; Shvedova A A; Kawai K; Tyurin V A; Kommineni C; Quinn P J; Schor N F; Fabisiak J P; Kagan V E
Phospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine.
Toxicology 2000;148(2-3):93-101.
2000: Kagan V E; Fabisiak J P; Shvedova A A; Tyurina Y Y; Tyurin V A; Schor N F; Kawai K
Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis.
FEBS letters 2000;477(1-2):1-7.
2000: Kagan V E; Kuzmenko A I; Shvedova A A; Kisin E R; Tyurina Y Y; Yalowich J C
Myeloperoxidase-catalyzed phenoxyl radicals of vitamin E homologue, 2,2,5,7,8-pentamethyl- 6-hydroxychromane, do not induce oxidative stress in live HL-60 cells.
Biochemical and biophysical research communications 2000;270(3):1086-92.
2000: Borisenko G G; Kagan V E; Hsia C J; Schor N F
Interaction between 6-hydroxydopamine and transferrin: "Let my iron go".
Biochemistry 2000;39(12):3392-400.
2000: Boota A; Johnson B; Lee K L; Blaskovich M A; Liu S X; Kagan V E; Hamilton A; Pitt B; Sebti S M; Davies P
Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L329-34.
2000: Shvedova A A; Kommineni C; Jeffries B A; Castranova V; Tyurina Y Y; Tyurin V A; Serbinova E A; Fabisiak J P; Kagan V E
Redox cycling of phenol induces oxidative stress in human epidermal keratinocytes.
The Journal of investigative dermatology 2000;114(2):354-64.
2000: Fabisiak J P; Tyurin V A; Tyurina Y Y; Sedlov A; Lazo J S; Kagan V E
Nitric oxide dissociates lipid oxidation from apoptosis and phosphatidylserine externalization during oxidative stress.
Biochemistry 2000;39(1):127-38.
2000: Fabisiak J P; Ritov V B; Kagan V E
Reversible thiol-dependent activation of ryanodine-sensitive Ca2+ release channel by etoposide (VP-16) phenoxyl radical.
Antioxidants & redox signaling 2000;2(1):73-82.
2000: Arroyo A; Kagan V E; Tyurin V A; Burgess J R; de Cabo R; Navas P; Villalba J M
NADH and NADPH-dependent reduction of coenzyme Q at the plasma membrane.
Antioxidants & redox signaling 2000;2(2):251-62.
1999: Goldman R; Claycamp G H; Sweetland M A; Sedlov A V; Tyurin V A; Kisin E R; Tyurina Y Y; Ritov V B; Wenger S L; Grant S G; Kagan V E
Myeloperoxidase-catalyzed redox-cycling of phenol promotes lipid peroxidation and thiol oxidation in HL-60 cells.
Free radical biology & medicine 1999;27(9-10):1050-63.
1999: Lange R W; Day B W; Lemus R; Tyurin V A; Kagan V E; Karol M H
Intracellular S-glutathionyl adducts in murine lung and human bronchoepithelial cells after exposure to diisocyanatotoluene.
Chemical research in toxicology 1999;12(10):931-6.
1999: Kagan V E; Yalowich J C; Borisenko G G; Tyurina Y Y; Tyurin V A; Thampatty P; Fabisiak J P
Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.
Molecular pharmacology 1999;56(3):494-506.
1999: Yalowich J C; Gorbunov N V; Kozlov A V; Allan W; Kagan V E
Mechanisms of nitric oxide protection against tert-butyl hydroperoxide-induced cytotoxicity in iNOS-transduced human erythroleukemia cells.
Biochemistry 1999;38(33):10691-8.
1999: Schor N F; Tyurina Y Y; Tyurin V A; Kagan V E
Differential membrane antioxidant effects of immediate and long-term estradiol treatment of MCF-7 breast cancer cells.
Biochemical and biophysical research communications 1999;260(2):410-5.
1999: Menshikova E V; Ritov V B; Gorbunov N V; Salama G; Claycamp H G; Kagan V E
Nitric oxide prevents myoglobin/tert-butyl hydroperoxide-induced inhibition of Ca2+ transport in skeletal and cardiac sarcoplasmic reticulum.
Annals of the New York Academy of Sciences 1999;874():371-85.
1999: Schor N F; Tyurina Y Y; Fabisiak J P; Tyurin V A; Lazo J S; Kagan V E
Selective oxidation and externalization of membrane phosphatidylserine: Bcl-2-induced potentiation of the final common pathway for apoptosis.
Brain research 1999;831(1-2):125-30.
1999: Shvedova A A; Tyurina Y Y; Gorbunov N V; Tyurin V A; Castranova V; Kommineni C; Ojimba J; Gandley R; McLaughlin M K; Kagan V E
tert-butyl hydroperoxide/hemoglobin-induced oxidative stress and damage to vascular smooth muscle cells: different effects of nitric oxide and nitrosothiols.
Biochemical pharmacology 1999;57(9):989-1001.
1999: Fabisiak J P; Tyurin V A; Tyurina Y Y; Borisenko G G; Korotaeva A; Pitt B R; Lazo J S; Kagan V E
Redox regulation of copper-metallothionein.
Archives of biochemistry and biophysics 1999;363(1):171-81.
1999: Day B W; Tyurin V A; Tyurina Y Y; Liu M; Facey J A; Carta G; Kisin E R; Dubey R K; Kagan V E
Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae.
Chemical research in toxicology 1999;12(1):28-37.
1999: Fabisiak J P; Pearce L L; Borisenko G G; Tyhurina Y Y; Tyurin V A; Razzack J; Lazo J S; Pitt B R; Kagan V E
Bifunctional anti/prooxidant potential of metallothionenin: redox signaling of copper binding and release.
Antioxidants & redox signaling 1999;1(3):349-64.
1998: Kagan V E; Tyurina Y Y
Recycling and redox cycling of phenolic antioxidants.
Annals of the New York Academy of Sciences 1998;854():425-34.
1998: Tyurin V A; Tyurina Y Y; Quinn P J; Schor N F; Balachandran R; Day B W; Kagan V E
Glutamate-induced cytotoxicity in PC12 pheochromocytoma cells: role of oxidation of phospholipids, glutathione and protein sulfhydryls revealed by bcl-2 transfection.
Brain research. Molecular brain research 1998;60(2):270-81.
1998: Fabisiak J P; Tyurina Y Y; Tyurin V A; Lazo J S; Kagan V E
Random versus selective membrane phospholipid oxidation in apoptosis: role of phosphatidylserine.
Biochemistry 1998;37(39):13781-90.
1998: Kagan V E; Arroyo A; Tyurin V A; Tyurina Y Y; Villalba J M; Navas P
Plasma membrane NADH-coenzyme Q0 reductase generates semiquinone radicals and recycles vitamin E homologue in a superoxide-dependent reaction.
FEBS letters 1998;428(1-2):43-6.
1998: Katz L M; Callaway C W; Kagan V E; Kochanek P M
Electron spin resonance measure of brain antioxidant activity during ischemia/reperfusion.
Neuroreport 1998;9(7):1587-93.
1998: Fabisiak J P; Kagan V E; Tyurina Y Y; Tyurin V A; Lazo J S
Paraquat-induced phosphatidylserine oxidation and apoptosis are independent of activation of PLA2.
The American journal of physiology 1998;274(5 Pt 1):L793-802.
1998: Gorbunov N V; Tyurina Y Y; Salama G; Day B W; Claycamp H G; Argyros G; Elsayed N M; Kagan V E
Nitric oxide protects cardiomyocytes against tert-butyl hydroperoxide-induced formation of alkoxyl and peroxyl radicals and peroxidation of phosphatidylserine.
Biochemical and biophysical research communications 1998;244(3):647-51.
1998: Kagan V E; Tyurina Y Y; Witt E
Role of coenzyme Q and superoxide in vitamin E cycling.
Sub-cellular biochemistry 1998;30():491-507.
1998: Day B W; Bergamini S; Tyurina Y Y; Carta G; Tyurin V A; Kagan V E
beta-Carotene. An antioxidant or a target of oxidative stress in cells?
Sub-cellular biochemistry 1998;30():209-17.
1998: Kagan V E; Gorbunov N V
EPR measurements of nitric oxide-induced chromanoxyl radicals of vitamin E. Interactions with vitamin C.
Methods in molecular biology (Clifton, N.J.) 1998;108():277-84.
1998: Kagan V E; Ritov V B; Tyurina Y Y; Tyurin V A
Sensitive and specific fluorescent probing of oxidative stress in different classes of membrane phospholipids in live cells using metabolically integrated cis-parinaric acid.
Methods in molecular biology (Clifton, N.J.) 1998;108():71-87.
1997: Pitt B R; Schwarz M; Woo E S; Yee E; Wasserloos K; Tran S; Weng W; Mannix R J; Watkins S A; Tyurina Y Y; Tyurin V A; Kagan V E; Lazo J S
Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury.
The American journal of physiology 1997;273(4 Pt 1):L856-65.
1997: Osaka K; Tyurina Y Y; Dubey R K; Tyurin V A; Ritov V B; Quinn P J; Branch R A; Kagan V E
Amphotericin B as an intracellular antioxidant: protection against 2,2'-azobis(2,4-dimethylvaleronitrile)-induced peroxidation of membrane phospholipids in rat aortic smooth muscle cells.
Biochemical pharmacology 1997;54(8):937-45.
1997: Tyurina Y Y; Tyurin V A; Carta G; Quinn P J; Schor N F; Kagan V E
Direct evidence for antioxidant effect of Bcl-2 in PC12 rat pheochromocytoma cells.
Archives of biochemistry and biophysics 1997;344(2):413-23.
1997: Elsayed N M; Gorbunov N V; Kagan V E
A proposed biochemical mechanism involving hemoglobin for blast overpressure-induced injury.
Toxicology 1997;121(1):81-90.
1997: Gorbunov N V; Yalowich J C; Gaddam A; Thampatty P; Ritov V B; Kisin E R; Elsayed N M; Kagan V E
Nitric oxide prevents oxidative damage produced by tert-butyl hydroperoxide in erythroleukemia cells via nitrosylation of heme and non-heme iron. Electron paramagnetic resonance evidence.
The Journal of biological chemistry 1997;272(19):12328-41.
1997: Osaka K; Ritov V B; Bernardo J F; Branch R A; Kagan V E
Amphotericin B protects cis-parinaric acid against peroxyl radical-induced oxidation: amphotericin B as an antioxidant.
Antimicrobial agents and chemotherapy 1997;41(4):743-7.
1997: Goldman R; Tsyrlov I B; Grogan J; Kagan V E
Reactions of phenoxyl radicals with NADPH-cytochrome P-450 oxidoreductase and NADPH: reduction of the radicals and inhibition of the enzyme.
Biochemistry 1997;36(11):3186-92.
1997: Gorbunov N V; Elsayed N M; Kisin E R; Kozlov A V; Kagan V E
Air blast-induced pulmonary oxidative stress: interplay among hemoglobin, antioxidants, and lipid peroxidation.
The American journal of physiology 1997;272(2 Pt 1):L320-34.
1997: Fabisiak J P; Kagan V E; Ritov V B; Johnson D E; Lazo J S
Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis.
The American journal of physiology 1997;272(2 Pt 1):C675-84.
1997: Tyurin V A; Carta G; Tyurina Y Y; Banni S; Day B W; Corongiu F P; Kagan V E
Peroxidase-catalyzed oxidation of beta-carotene in HL-60 cells and in model systems: involvement of phenoxyl radicals.
Lipids 1997;32(2):131-42.
1997: Hubel C A; Kagan V E; Kisin E R; McLaughlin M K; Roberts J M
Increased ascorbate radical formation and ascorbate depletion in plasma from women with preeclampsia: implications for oxidative stress.
Free radical biology & medicine 1997;23(4):597-609.
1996: Ritov V B; Menshikova E V; Goldman R; Kagan V E
Direct oxidation of polyunsaturated cis-parinaric fatty acid by phenoxyl radicals generated by peroxidase/H2O2 in model systems and in HL-60 cells.
Toxicology letters 1996;87(2-3):121-9.
1996: Ritov V B; Banni S; Yalowich J C; Day B W; Claycamp H G; Corongiu F P; Kagan V E
Non-random peroxidation of different classes of membrane phospholipids in live cells detected by metabolically integrated cis-parinaric acid.
Biochimica et biophysica acta 1996;1283(2):127-40.
1996: Stoyanovosky D A; Goldman R; Jonnalagadda S S; Day B W; Claycamp H G; Kagan V E
Detection and characterization of the electron paramagnetic resonance-silent glutathionyl-5,5-dimethyl-1-pyrroline N-oxide adduct derived from redox cycling of phenoxyl radicals in model systems and HL-60 cells.
Archives of biochemistry and biophysics 1996;330(1):3-11.
1996: Purpura P; Westman L; Will P; Eidelman A; Kagan V E; Osipov A N; Schor N F
Adjunctive treatment of murine neuroblastoma with 6-hydroxydopamine and Tempol.
Cancer research 1996;56(10):2336-42.
1996: Elsayed N M; Tyurina Y Y; Tyurin V A; Menshikova E V; Kisin E R; Kagan V E
Antioxidant depletion, lipid peroxidation, and impairment of calcium transport induced by air-blast overpressure in rat lungs.
Experimental lung research 1996;22(2):179-200.
1996: Gorbunov N V; Osipov A N; Sweetland M A; Day B W; Elsayed N M; Kagan V E
NO-redox paradox: direct oxidation of alpha-tocopherol and alpha-tocopherol-mediated oxidation of ascorbate.
Biochemical and biophysical research communications 1996;219(3):835-41.
1996: Osipov A N; Gorbunov N V; Day B W; Elsayed N M; Kagan V E
Electron spin resonance and mass spectral analysis of interactions of ferrylhemoglobin and ferrylmyoglobin with nitric oxide.
Methods in enzymology 1996;268():193-203.
1995: Kurella E G; Osipov A N; Goldman R; Boldyrev A A; Kagan V E
Inhibition of Na+/K(+)-ATPase by phenoxyl radicals of etoposide (VP-16): role of sulfhydryls oxidation.
Biochimica et biophysica acta 1995;1232(1-2):52-8.
1995: Stoyanovsky D A; Osipov A N; Quinn P J; Kagan V E
Ubiquinone-dependent recycling of vitamin E radicals by superoxide.
Archives of biochemistry and biophysics 1995;323(2):343-51.
1995: Shvedova A A; Menshikova E V; Ritov V B; Kagan V E; Karol M H
Murine pulmonary Ca(2+)-transport system activated by allergic immune response retains sensitivity to oxidative stress.
Experimental lung research 1995;21(5):743-70.
1995: Ritov V B; Goldman R; Stoyanovsky D A; Menshikova E V; Kagan V E
Antioxidant paradoxes of phenolic compounds: peroxyl radical scavenger and lipid antioxidant, etoposide (VP-16), inhibits sarcoplasmic reticulum Ca(2+)-ATPase via thiol oxidation by its phenoxyl radical.
Archives of biochemistry and biophysics 1995;321(1):140-52.
1995: Gorbunov N V; Osipov A N; Day B W; Zayas-Rivera B; Kagan V E; Elsayed N M
Reduction of ferrylmyoglobin and ferrylhemoglobin by nitric oxide: a protective mechanism against ferryl hemoprotein-induced oxidations.
Biochemistry 1995;34(20):6689-99.
1995: Shvedova A A; Kisin E R; Kagan V E; Karol M H
Increased lipid peroxidation and decreased antioxidants in lungs of guinea pigs following an allergic pulmonary response.
Toxicology and applied pharmacology 1995;132(1):72-81.
1995: Goldman R; Stoyanovsky D A; Day B W; Kagan V E
Reduction of phenoxyl radicals by thioredoxin results in selective oxidation of its SH-groups to disulfides. An antioxidant function of thioredoxin.
Biochemistry 1995;34(14):4765-72.
1995: Tyurina Y Y; Tyurin V A; Yalowich J C; Quinn P J; Claycamp H G; Schor N F; Pitt B R; Kagan V E
Phenoxyl radicals of etoposide (VP-16) can directly oxidize intracellular thiols: protective versus damaging effects of phenolic antioxidants.
Toxicology and applied pharmacology 1995;131(2):277-88.
1995: Menshikova E V; Ritov V B; Shvedova A A; Elsayed N; Karol M H; Kagan V E
Pulmonary microsomes contain a Ca(2+)-transport system sensitive to oxidative stress.
Biochimica et biophysica acta 1995;1228(2-3):165-74.
1995: Stoyanovsky D A; Goldman R; Claycamp H G; Kagan V E
Phenoxyl radical-induced thiol-dependent generation of reactive oxygen species: implications for benzene toxicity.
Archives of biochemistry and biophysics 1995;317(2):315-23.
1995: Stoyanovsky D A; Goldman R; Darrow R M; Organisciak D T; Kagan V E
Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with exogenous dihydrolipoic acid.
Current eye research 1995;14(3):181-9.
1994: Kagan V E; Yalowich J C; Day B W; Goldman R; Gantchev T G; Stoyanovsky D A
Ascorbate is the primary reductant of the phenoxyl radical of etoposide in the presence of thiols both in cell homogenates and in model systems.
Biochemistry 1994;33(32):9651-60.
1994: Schwarz M A; Lazo J S; Yalowich J C; Reynolds I; Kagan V E; Tyurin V; Kim Y M; Watkins S C; Pitt B R
Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity.
The Journal of biological chemistry 1994;269(21):15238-43.
1994: Stoyanovsky D A; Salama G; Kagan V E
Ascorbate/iron activates Ca(2+)-release channels of skeletal sarcoplasmic reticulum vesicles reconstituted in lipid bilayers.
Archives of biochemistry and biophysics 1994;308(1):214-21.
1994: Gantchev T G; van Lier J E; Stoyanovsky D A; Yalowich J C; Kagan V E
Interactions of phenoxyl radical of antitumor drug, etoposide, with reductants in solution and in cell and nuclear homogenates: electron spin resonance and high-performance liquid chromatography.
Methods in enzymology 1994;234():631-42.
1994: Kagan V E; Packer L
Light-induced generation of vitamin E radicals: assessing vitamin E regeneration.
Methods in enzymology 1994;234():316-20.
1993: Stoyanovsky D; Yalowich J; Gantchev T; Kagan V
Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates.
Free radical research communications 1993;19(6):371-86.

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