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Hiroyuki Kagechika

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Kudo Mayumi; Hanashima Takayuki; Muranaka Atsuya; Sato Hisako; Uchiyama Masanobu; Azumaya Isao; Hirano Tomoya; Kagechika Hiroyuki; Tanatani Aya
Identification of absolute helical structures of aromatic multilayered oligo(m-phenylurea)s in solution.
Tsai Nien-Pei; Huq Mostaqul; Gupta Pawan; Yamamoto Keiko; Kagechika Hiroyuki; Wei Li-Na
Activation of testicular orphan receptor 4 by fatty acids.
Bianchi Massimiliano G; Gazzola Gian C; Cagnin Silvia; Kagechika Hiroyuki; Bussolati Ovidio
The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.

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All Publications

2009: Kudo Mayumi; Hanashima Takayuki; Muranaka Atsuya; Sato Hisako; Uchiyama Masanobu; Azumaya Isao; Hirano Tomoya; Kagechika Hiroyuki; Tanatani Aya
Identification of absolute helical structures of aromatic multilayered oligo(m-phenylurea)s in solution.
The Journal of organic chemistry 2009;74(21):8154-63.
2009: Tsai Nien-Pei; Huq Mostaqul; Gupta Pawan; Yamamoto Keiko; Kagechika Hiroyuki; Wei Li-Na
Activation of testicular orphan receptor 4 by fatty acids.
Biochimica et biophysica acta 2009;1789(11-12):734-40.
2009: Bianchi Massimiliano G; Gazzola Gian C; Cagnin Silvia; Kagechika Hiroyuki; Bussolati Ovidio
The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.
Biochimica et biophysica acta 2009;1788(9):1861-8.
2009: Suzuki Kazushige; Takahashi Katsuhiko; Nishimaki-Mogami Tomoko; Kagechika Hiroyuki; Yamamoto Matsuo; Itabe Hiroyuki
Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid x receptor in human choriocarcinoma BeWo cells.
Biological & pharmaceutical bulletin 2009;32(7):1177-82.
2009: Hatanaka Misaki; Shimba Shigeki; Sakaue Motoharu; Kondo Yukihiro; Kagechika Hiroyuki; Kokame Koichi; Miyata Toshiyuki; Hara Shuntaro
Hypoxia-inducible factor-3alpha functions as an accelerator of 3T3-L1 adipose differentiation.
Biological & pharmaceutical bulletin 2009;32(7):1166-72.
2009: Satoh Taku; Higuchi Yuriko; Kawakami Shigeru; Hashida Mitsuru; Kagechika Hiroyuki; Shudo Koichi; Yokoyama Masayuki
Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control.
Journal of controlled release : official journal of the Controlled Release Society 2009;136(3):187-95.
2009: Kurosu Tetsuya; Ohki Manabu; Wu Nan; Kagechika Hiroyuki; Miura Osamu
Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.
Cancer research 2009;69(9):3927-36.
2009: Ohashi Emi; Kogai Takahiko; Kagechika Hiroyuki; Brent Gregory A
Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells.
Cancer research 2009;69(8):3443-50.
2009: Bourhis Emmanuelle; Maheux Jérôme; Paquet Brigitte; Kagechika Hiroyuki; Shudo Koichi; Rompré Pierre-Paul; Rouillard Claude; Lévesque Daniel
The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities.
Psychopharmacology 2009;202(4):635-48.
2009: Takahashi Yu; Inoue Jun; Kagechika Hiroyuki; Sato Ryuichiro
ApoC-III gene expression is sharply increased during adipogenesis and is augmented by retinoid X receptor (RXR) agonists.
FEBS letters 2009;583(2):493-7.
2009: Eshima Kokoro; Fukaya Satoshi; Sugimoto Akiko; Mori Tomoko; Yokoi Hiromi; Yamamoto Yasuji; Sugiura Shin; Honda Shizu; Masuko Norio; Murakami Koji; Yamasaki Yasundo; Kagechika Hiroyuki
Contribution of AP-1 interference induced by TAC-101 to tumor growth suppression in a hepatocellular carcinoma model.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2009;30(1):1-7.
2008: Nishimaki-Mogami Tomoko; Tamehiro Norimasa; Sato Yoji; Okuhira Kei-ichiro; Sai Kimie; Kagechika Hiroyuki; Shudo Koichi; Abe-Dohmae Sumiko; Yokoyama Shinji; Ohno Yasuo; Inoue Kazuhide; Sawada Jun-ichi
The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines.
Biochemical pharmacology 2008;76(8):1006-13.
2008: Liu Ying; Kagechika Hiroyuki; Ishikawa Junko; Hirano Hitoshi; Matsukuma Satoshi; Tanaka Kazuko; Nakamura Shoji
Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons.
Journal of neurochemistry 2008;106(3):1104-16.
2008: Kagechika Hiroyuki
[Chemical biology research on nuclear receptors]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2008;132(1):11-7.
2008: Masu Hyuma; Katagiri Kosuke; Kato Takako; Kagechika Hiroyuki; Tominaga Masahide; Azumaya Isao
Chiral spherical molecule constructed from aromatic amides: facile synthesis and highly ordered network structure in the crystal.
The Journal of organic chemistry 2008;73(13):5143-6.
2008: Taoda Yoshiyuki; Sawabe Takehiko; Endo Yasuyuki; Yamaguchi Kentaro; Fujii Shinya; Kagechika Hiroyuki
Identification of an intermediate in the deboronation of ortho-carborane: an adduct of ortho-carborane with two nucleophiles on one boron atom.
Chemical communications (Cambridge, England) 2008;(17):2049-51.
2008: Ishikawa Junko; Sutoh Chihiro; Ishikawa Akinori; Kagechika Hiroyuki; Hirano Hitoshi; Nakamura Shoji
13-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat.
The European journal of neuroscience 2008;27(9):2363-72.
2007: Okamoto Iwao; Yamasaki Ryu; Sawamura Mika; Kato Takako; Nagayama Naomi; Takeya Tetsuya; Tamura Osamu; Masu Hyuma; Azumaya Isao; Yamaguchi Kentaro; Kagechika Hiroyuki; Tanatani Aya
Redox-induced conformational alteration of n,n-diarylamides.
Organic letters 2007;9(26):5545-7.
2007: Miwako Ishido; Kagechika Hiroyuki
Tamibarotene.
Drugs of today (Barcelona, Spain : 1998) 2007;43(8):563-8.
2007: Matsumoto Akira; Mizukami Hajime; Mizuno Satoshi; Umegaki Keizo; Nishikawa Jun-ichi; Shudo Koichi; Kagechika Hiroyuki; Inoue Makoto
beta-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages.
Biochemical pharmacology 2007;74(2):256-64.
2007: Dai Xiuju; Sayama Koji; Shirakata Yuji; Hanakawa Yasushi; Yamasaki Kenshi; Tokumaru Sho; Yang Lujun; Wang Xiaoling; Hirakawa Satoshi; Tohyama Mikiko; Yamauchi Toshimasa; Takashi Kadowaki; Kagechika Hiroyuki; Hashimoto Koji
STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiation.
The Journal of investigative dermatology 2007;127(7):1728-35.
2007: Komatsu Takuma; Hirano Tomoya; Songkram Chalermkiat; Kawachi Emiko; Kagechika Hiroyuki
Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton.
Bioorganic & medicinal chemistry 2007;15(9):3115-26.
2007: Hirano Tomoya; Hiromoto Kenichi; Kagechika Hiroyuki
Development of a library of 6-arylcoumarins as candidate fluorescent sensors.
Organic letters 2007;9(7):1315-8.
2007: Saito Akiko; Sugawara Akira; Uruno Akira; Kudo Masataka; Kagechika Hiroyuki; Sato Yasufumi; Owada Yuji; Kondo Hisatake; Sato Mayumi; Kurabayashi Masahiko; Imaizumi Masue; Tsuchiya Shigeru; Ito Sadayoshi
All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling.
Endocrinology 2007;148(3):1412-23.
2006: Haraguchi Go; Suzuki Jun-Ichi; Kosuge Hisanori; Ogawa Masahito; Koga Noritaka; Muto Susumu; Itai Akiko; Kagechika Hiroyuki; Shudo Koichi; Isobe Mitsuaki
A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.
Journal of molecular and cellular cardiology 2006;41(5):885-92.
2006: Kato Takako; Okamoto Iwao; Tanatani Aya; Hatano Terutaka; Uchiyama Masanobu; Kagechika Hiroyuki; Masu Hyuma; Katagiri Kosuke; Tominaga Masahide; Yamaguchi Kentaro; Azumaya Isao
Spontaneous resolution of aromatic sulfonamides: effective screening method and discrimination of absolute structure.
Organic letters 2006;8(22):5017-20.
2006: Ohashi Emi; Miyajima Nozomi; Nakagawa Takayuki; Takahashi Tomoko; Kagechika Hiroyuki; Mochizuki Manabu; Nishimura Ryohei; Sasaki Nobuo
Retinoids induce growth inhibition and apoptosis in mast cell tumor cell lines.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2006;68(8):797-802.
2006: Fukasawa Hiroshi; Kagechika Hiroyuki; Shudo Koichi
[Retinoid therapy for autoimmune diseases]
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2006;29(3):114-26.
2006: Calléja Cécile; Messaddeq Nadia; Chapellier Benoit; Yang Haiyuan; Krezel Wojciech; Li Mei; Metzger Daniel; Mascrez Bénédicte; Ohta Kiminori; Kagechika Hiroyuki; Endo Yasuyuki; Mark Manuel; Ghyselinck Norbert B; Chambon Pierre
Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.
Genes & development 2006;20(11):1525-38.
2006: Takeda Norifumi; Manabe Ichiro; Shindo Takayuki; Iwata Hiroshi; Iimuro Satoshi; Kagechika Hiroyuki; Shudo Koichi; Nagai Ryozo
Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(5):1177-83.
2006: Yasugi Etsuko; Horiuchi Akiko; Uemura Isao; Okuma Emiko; Nakatsu Masami; Saeki Kumiko; Kamisaka Yasushi; Kagechika Hiroyuki; Yasuda Kazuki; Yuo Akira
Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells.
Development, growth & differentiation 2006;48(3):177-88.
2005: Lou Yan-Ru; Miettinen Susanna; Kagechika Hiroyuki; Gronemeyer Hinrich; Tuohimaa Pentti
Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
Biochemical and biophysical research communications 2005;338(4):1973-81.
2005: Morita Kentaro; Kawana Katsuyoshi; Sodeyama Mariko; Shimomura Iichiro; Kagechika Hiroyuki; Makishima Makoto
Selective allosteric ligand activation of the retinoid X receptor heterodimers of NGFI-B and Nurr1.
Biochemical pharmacology 2005;71(1-2):98-107.
2005: Fujiu Katsuhito; Manabe Ichiro; Ishihara Atsushi; Oishi Yumiko; Iwata Hiroshi; Nishimura Go; Shindo Takayuki; Maemura Koji; Kagechika Hiroyuki; Shudo Koichi; Nagai Ryozo
Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5.
Circulation research 2005;97(11):1132-41.
2005: Kagechika Hiroyuki; Shudo Koichi
Synthetic retinoids: recent developments concerning structure and clinical utility.
Journal of medicinal chemistry 2005;48(19):5875-83.
2005: Uruno Akira; Sugawara Akira; Kanatsuka Hiroshi; Kagechika Hiroyuki; Saito Akiko; Sato Kazunori; Kudo Masataka; Takeuchi Kazuhisa; Ito Sadayoshi
Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway.
Circulation 2005;112(5):727-36.
2005: Honda Masahiko; Hamazaki Tatsuo S; Komazaki Shinji; Kagechika Hiroyuki; Shudo Koichi; Asashima Makoto
RXR agonist enhances the differentiation of cardiomyocytes derived from embryonic stem cells in serum-free conditions.
Biochemical and biophysical research communications 2005;333(4):1334-40.
2005: Kagechika Hiroyuki; Miyachi Hiroyuki
[PPARs as molecular targets for drug discovery]
Nippon rinsho. Japanese journal of clinical medicine 2005;63(4):549-55.
2004: Ohta Kiminori; Iijima Toru; Kawachi Emiko; Kagechika Hiroyuki; Endo Yasuyuki
Novel retinoid X receptor (RXR) antagonists having a dicarba-closo-dodecaborane as a hydrophobic moiety.
Bioorganic & medicinal chemistry letters 2004;14(23):5913-8.
2004: Ishida Seiichi; Shigemoto-Mogami Yukari; Shinozaki Youichi; Kagechika Hiroyuki; Shudo Koichi; Ozawa Shogo; Sawada Jun-ichi; Ohno Yasuo; Inoue Kazuhide
Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis.
Biochemical pharmacology 2004;68(11):2177-86.
2004: Shudo Koichi; Kagechika Hiroyuki; Yamazaki Noriyuki; Igarashi Masaharu; Tateda Chiaki
A synthetic retinoid Am80 (tamibarotene) rescues the memory deficit caused by scopolamine in a passive avoidance paradigm.
Biological & pharmaceutical bulletin 2004;27(11):1887-9.
2004: Iwata Makoto; Hirakiyama Asami; Eshima Yuko; Kagechika Hiroyuki; Kato Chieko; Song Si-Young
Retinoic acid imprints gut-homing specificity on T cells.
Immunity 2004;21(4):527-38.
2004: Ethier Isabelle; Kagechika Hiroyuki; Shudo Koichi; Rouillard Claude; Lévesque Daniel
Docosahexaenoic acid reduces haloperidol-induced dyskinesias in mice: involvement of Nur77 and retinoid receptors.
Biological psychiatry 2004;56(7):522-6.
2004: Sato Atsushi; Imaizumi Masue; Hoshi Yoshiyuki; Rikiishi Takeshi; Fujii Kunihiro; Kizaki Masahiro; Kagechika Hiroyuki; Kakizuka Akira; Hayashi Yutaka; Iinuma Kazuie
Alteration in the cellular response to retinoic acid of a human acute promyelocytic leukemia cell line, UF-1, carrying a patient-derived mutant PML-RARalpha chimeric gene.
Leukemia research 2004;28(9):959-67.
2004: Kurihara Masaaki; Rouf Abu Shara Shamsur; Kansui Hisao; Kagechika Hiroyuki; Okuda Haruhiro; Miyata Naoki
Design and synthesis of cyclic urea compounds: a pharmacological study for retinoidal activity.
Bioorganic & medicinal chemistry letters 2004;14(16):4131-4.
2004: Akanmu Moses A; Songkram Chalermkiat; Kagechika Hiroyuki; Honda Kazuki
A novel melatonin derivative modulates sleep-wake cycle in rats.
Neuroscience letters 2004;364(3):199-202.
2004: Iwata Makoto; Eshima Yuko; Kagechika Hiroyuki; Miyaura Hideki
The endocrine disruptors nonylphenol and octylphenol exert direct effects on T cells to suppress Th1 development and enhance Th2 development.
Immunology letters 2004;94(1-2):135-9.
2003: Endo Yasuyuki; Yamamoto Keisuke; Kagechika Hiroyuki
Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types of carboranyl groups.
Bioorganic & medicinal chemistry letters 2003;13(22):4089-92.
2003: Azumaya Isao; Kato Takako; Okamoto Iwao; Yamasaki Ryu; Tanatani Aya; Yamaguchi Kentaro; Kagechika Hiroyuki; Takayanagi Hiroaki
Absolute helical arrangement of sulfonamide in the crystal.
Organic letters 2003;5(21):3939-42.
2003: Suizu Mamiko; Muroya Yohei; Kakuta Hiroki; Kagechika Hiroyuki; Tanatani Aya; Nagasawa Kazuo; Hashimoto Yuichi
Cyclooxygenase inhibitors derived from thalidomide.
Chemical & pharmaceutical bulletin 2003;51(9):1098-102.
2003: Iwata Makoto; Eshima Yuko; Kagechika Hiroyuki
Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.
International immunology 2003;15(8):1017-25.
2003: Yamasaki Ryu; Tanatani Aya; Azumaya Isao; Saito Shoichi; Yamaguchi Kentaro; Kagechika Hiroyuki
Amide conformational switching induced by protonation of aromatic substituent.
Organic letters 2003;5(8):1265-7.
2003: Farooqui Mariya; Franco Peter J; Thompson Jim; Kagechika Hiroyuki; Chandraratna Roshantha A S; Banaszak Len; Wei Li-Na
Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity.
Biochemistry 2003;42(4):971-9.
2003: Ishida Seiichi; Shigemoto-Mogami Yukari; Kagechika Hiroyuki; Shudo Koichi; Ozawa Shogo; Sawada Jun-Ichi; Ohno Yasuo; Inoue Kazuhide
Clinically potential subclasses of retinoid synergists revealed by gene expression profiling.
Molecular cancer therapeutics 2003;2(1):49-58.
2003: Miyagawa Naoki; Homma Takeyasu; Kagechika Hiroyuki; Shudo Koichi; Nagai Hiroichi
Effect of synthetic retinoid, TAC-101, on experimental autoimmune disease.
Pharmacology 2003;67(1):21-31.
2002: Takahashi Bitoku; Ohta Kiminori; Kawachi Emiko; Fukasawa Hiroshi; Hashimoto Yuichi; Kagechika Hiroyuki
Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.
Journal of medicinal chemistry 2002;45(16):3327-30.
2002: Shindo Takayuki; Manabe Ichiro; Fukushima Yasushi; Tobe Kazuyuki; Aizawa Kenichi; Miyamoto Saku; Kawai-Kowase Keiko; Moriyama Nobuo; Imai Yasushi; Kawakami Hayato; Nishimatsu Hiroaki; Ishikawa Takashi; Suzuki Toru; Morita Hiroyuki; Maemura Koji; Sata Masataka; Hirata Yasunobu; Komukai Masayuki; Kagechika Hiroyuki; Kadowaki Takashi; Kurabayashi Masahiko; Nagai Ryozo
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Nature medicine 2002;8(8):856-63.
2002: Kagechika Hiroyuki
Novel synthetic retinoids and separation of the pleiotropic retinoidal activities.
Current medicinal chemistry 2002;9(5):591-608.
2002: Ohashi Emi; Inoue Kaori; Kagechika Hiroyuki; Hong Sung-Hyeok; NakagawaTakayuki; Takahashi Tomoko; Mochizuki Manabu; Nishimura Ryouhei; Sasaki Nobuo
Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2002;64(2):169-72.
2001: Yamauchi T; Waki H; Kamon J; Murakami K; Motojima K; Komeda K; Miki H; Kubota N; Terauchi Y; Tsuchida A; Tsuboyama-Kasaoka N; Yamauchi N; Ide T; Hori W; Kato S; Fukayama M; Akanuma Y; Ezaki O; Itai A; Nagai R; Kimura S; Tobe K; Kagechika H; Shudo K; Kadowaki T
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
The Journal of clinical investigation 2001;108(7):1001-13.
2001: Yamauchi T; Kamon J; Waki H; Terauchi Y; Kubota N; Hara K; Mori Y; Ide T; Murakami K; Tsuboyama-Kasaoka N; Ezaki O; Akanuma Y; Gavrilova O; Vinson C; Reitman M L; Kagechika H; Shudo K; Yoda M; Nakano Y; Tobe K; Nagai R; Kimura S; Tomita M; Froguel P; Kadowaki T
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Nature medicine 2001;7(8):941-6.
2001: Sou S; Takahashi H; Yamasaki R; Kagechika H; Endo Y; Hashimoto Y
Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group.
Chemical & pharmaceutical bulletin 2001;49(6):791-3.
2001: Endo Y; Iijima T; Yaguchi K; Kawachi E; Inoue N; Kagechika H; Kubo A; Itai A
Structure-Activity study of retinoid agonists bearing substituted dicarba-closo-dodecaborane. Relation between retinoidal activity and conformation of two aromatic nuclei.
Bioorganic & medicinal chemistry letters 2001;11(10):1307-11.
2001: Ebisawa M; Ohta K; Kawachi E; Fukasawa H; Hashimoto Y; Kagechika H
Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure.
Chemical & pharmaceutical bulletin 2001;49(4):501-3.
2000: Ohta K; Kawachi E; Inoue N; Fukasawa H; Hashimoto Y; Itai A; Kagechika H
Retinoidal pyrimidinecarboxylic acids. Unexpected diaza-substituent effects in retinobenzoic acids.
Chemical & pharmaceutical bulletin 2000;48(10):1504-13.
2000: Endo Y; Yaguchi K; Kawachi E; Kagechika H
Polymethylcarborane as a novel bioactive moiety: derivatives with potent retinoid antagonistic activity.
Bioorganic & medicinal chemistry letters 2000;10(15):1733-6.
1999: Ebisawa M; Umemiya H; Ohta K; Fukasawa H; Kawachi E; Christoffel G; Gronemeyer H; Tsuji M; Hashimoto Y; Shudo K; Kagechika H
Retinoid X receptor-antagonistic diazepinylbenzoic acids.
Chemical & pharmaceutical bulletin 1999;47(12):1778-86.
1999: Ebisawa M; Inoue N; Fukasawa H; Sotome T; Kagechika H
Thiazolidinediones with thyroid hormone receptor agonistic activity.
Chemical & pharmaceutical bulletin 1999;47(9):1348-50.
1999: Kagechika H; Komoda M; Fujimoto Y; Koiso Y; Takayama H; Kadoya S; Miyata K; Kato F; Kato M; Hashimoto Y
Potent homophthalimide-type inhibitors of B16F10/L5 mouse melanoma cell invasion.
Biological & pharmaceutical bulletin 1999;22(9):1010-2.
1999: Endo Y; Iijima T; Kagechika H; Ohta K; Kawachi E; Shudo K
Dicarba-closo-dodecaboranes as a pharmacophore. Novel potent retinoidal agonists.
Chemical & pharmaceutical bulletin 1999;47(4):585-7.
1999: Iijima T; Endo Y; Tsuji M; Kawachi E; Kagechika H; Shudo K
Dicarba-closo-dodecaboranes as a pharmacophore. Retinoidal antagonists and potential agonists.
Chemical & pharmaceutical bulletin 1999;47(3):398-404.
1998: Ebisawa M; Kawachi E; Fukasawa H; Hashimoto Y; Itai A; Shudo K; Kagechika H
Novel thiazolidinedione derivatives with retinoid synergistic activity.
Biological & pharmaceutical bulletin 1998;21(5):547-9.
1998: Ohta K; Tsuji M; Kawachi E; Fukasawa H; Hashimoto Y; Shudo K; Kagechika H
Potent retinoid synergists with a diphenylamine skeleton.
Biological & pharmaceutical bulletin 1998;21(5):544-6.
1997: Umemiya H; Fukasawa H; Ebisawa M; Eyrolles L; Kawachi E; Eisenmann G; Gronemeyer H; Hashimoto Y; Shudo K; Kagechika H
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
Journal of medicinal chemistry 1997;40(26):4222-34.
1997: Tashima T; Kagechika H; Tsuji M; Fukasawa H; Kawachi E; Hashimoto Y; Shudo K
Polyenylidene thiazolidinedione derivatives with retinoidal activities.
Chemical & pharmaceutical bulletin 1997;45(11):1805-13.
1997: Vivat V; Zechel C; Wurtz J M; Bourguet W; Kagechika H; Umemiya H; Shudo K; Moras D; Gronemeyer H; Chambon P
A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers.
The EMBO journal 1997;16(18):5697-709.
1997: Sasaki T; Morisaki N; Iwasaki S; Kagechika H; Fukasawa H; Shudo K; Shida Y; Hashimoto Y
Photoaffinity labeling of the ligand-interacting helix of the retinoic acid receptor alpha.
Biological & pharmaceutical bulletin 1997;20(8):913-6.
1997: Umemiya H; Kagechika H; Fukasawa H; Kawachi E; Ebisawa M; Hashimoto Y; Eisenmann G; Erb C; Pornon A; Chambon P; Gronemeyer H; Shudo K
Action mechanism of retinoid-synergistic dibenzodiazepines.
Biochemical and biophysical research communications 1997;233(1):121-5.
1997: Kagechika H; Kawachi E; Fukasawa H; Saito G; Iwanami N; Umemiya H; Hashimoto Y; Shudo K
Inhibition of IL-1-induced IL-6 production by synthetic retinoids.
Biochemical and biophysical research communications 1997;231(2):243-8.
1996: Umemiya H; Kagechika H; Fukasawa H; Hashimoto Y; Shudo K
[Retinoid antagonists]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1996;116(12):928-41.
1996: Hashimoto Y; Kagechika H; Kawachi E; Fukasawa H; Saito G; Shudo K
Evaluation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.
Biological & pharmaceutical bulletin 1996;19(10):1322-8.
1996: Fukutomi R; Kagechika H; Hashimoto Y; Shudo K
Novel aromatic urea derivatives with DNA-binding ability.
Chemical & pharmaceutical bulletin 1996;44(10):1983-5.
1995: Umemiya H; Kawachi E; Kagechika H; Fukasawa H; Hashimoto Y; Shudo K
Synergists for retinoid in cellular differentiation of human promyelocytic leukemia cells HL-60.
Chemical & pharmaceutical bulletin 1995;43(10):1827-9.
1995: Nakajima O; Kagechika H; Shudo K; Hashimoto Y; Iwasaki S
Possible involvement of retinoid-like cofactor in serum in hemin/protoporphyrin-IX-induced differentiation of human leukemia K562 cells.
Biochemical and biophysical research communications 1995;206(3):1003-10.
1995: Umemiya H; Komatsu K; Yamazaki T; Kagechika H; Shudo K; Hashimoto Y
Synthesis of oligopeptides as polynucleotide analogs.
Nucleic acids symposium series 1995;(34):37-8.
1995: Hashimoto Y; Kagechika H; Kawachi E; Fukasawa H; Saito G; Shudo K
Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.
Journal of cancer research and clinical oncology 1995;121(11):696-8.
1994: Eyrolles L; Kawachi E; Kagechika H; Hashimoto Y; Shudo K
Synthesis and biological activity of carboxyphenylquinolines and related compounds as new potent retinoids. Retinobenzoic acids. VII.
Chemical & pharmaceutical bulletin 1994;42(12):2575-81.
1994: Kagechika H
[Novel synthetic retinoid agonists and antagonists]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1994;114(11):847-62.
1994: Azumaya I; Yamaguchi K; Kagechika H; Saito S; Itai A; Shudo K
[Stereochemistry of benzanilides and N-methylbenzanilides]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1994;114(6):414-30.
1994: Eyrolles L; Kagechika H; Kawachi E; Fukasawa H; Iijima T; Matsushima Y; Hashimoto Y; Shudo K
Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring.
Journal of medicinal chemistry 1994;37(10):1508-17.
1993: Fukasawa H; Iijima T; Kagechika H; Hashimoto Y; Shudo K
Expression of the ligand-binding domain-containing region of retinoic acid receptors alpha, beta and gamma in Escherichia coli and evaluation of ligand-binding selectivity.
Biological & pharmaceutical bulletin 1993;16(4):343-8.
1992: Matsushima Y; Kawachi E; Tanaka H; Kagechika H; Hashimoto Y; Shudo K
Differentiation-inducing activity of retinoic acid isomers and their oxidized analogs on human promyelocytic leukemia HL-60 cells.
Biochemical and biophysical research communications 1992;189(2):1136-42.
1992: Tanaka H; Kagechika H; Kawachi E; Fukasawa H; Hashimoto Y; Shudo K
Base-catalyzed isomerization of retinoic acid. Synthesis and differentiation-inducing activities of 14-alkylated all-trans-, 13-cis-, and 20,14-retro-retinoic acids.
Journal of medicinal chemistry 1992;35(3):567-72.
1991: Shimazawa R; Hibino S; Mizoguchi H; Hashimoto Y; Iwasaki S; Kagechika H; Shudo K
Fluorescent probes for retinoic acid receptors: molecular measures for the ligand binding pocket.
Biochemical and biophysical research communications 1991;180(1):249-54.
1991: Shimazawa R; Sanda R; Mizoguchi H; Hashimoto Y; Iwasaki S; Tanaka H; Kagechika H; Shudo K
Fluorescent and photoaffinity labeling probes for retinoic acid receptors.
Biochemical and biophysical research communications 1991;179(1):259-65.
1990: Yamakawa T; Kagechika H; Kawachi E; Hashimoto Y; Shudo K
Retinobenzoic acids. 5. Retinoidal activities of compounds having a trimethylsilyl or trimethylgermyl group(s) in human promyelocytic leukemia cells HL-60.
Journal of medicinal chemistry 1990;33(5):1430-7.
1990: Hashimoto Y; Kagechika H; Shudo K
Expression of retinoic acid receptor genes and the ligand-binding selectivity of retinoic acid receptors (RAR's).
Biochemical and biophysical research communications 1990;166(3):1300-7.
1989: Kagechika H; Himi T; Kawachi E; Shudo K
Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity.
Journal of medicinal chemistry 1989;32(10):2292-6.
1989: Hashimoto Y; Petkovich M; Gaub M P; Kagechika H; Shudo K; Chambon P
The retinoic acid receptors alpha and beta are expressed in the human promyelocytic leukemia cell line HL-60.
Molecular endocrinology (Baltimore, Md.) 1989;3(7):1046-52.
1989: Kagechika H; Himi T; Namikawa K; Kawachi E; Hashimoto Y; Shudo K
Retinobenzoic acids. 3. Structure-activity relationships of retinoidal azobenzene-4-carboxylic acids and stilbene-4-carboxylic acids.
Journal of medicinal chemistry 1989;32(5):1098-108.
1989: Kagechika H; Kawachi E; Hashimoto Y; Shudo K
Retinobenzoic acids. 2. Structure-activity relationships of chalcone-4-carboxylic acids and flavone-4'-carboxylic acids.
Journal of medicinal chemistry 1989;32(4):834-40.
1988: Kagechika H; Kawachi E; Hashimoto Y; Himi T; Shudo K
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
Journal of medicinal chemistry 1988;31(11):2182-92.
1988: Kagechika H; Hashimoto Y; Kawachi E; Shudo K
[Recent advances in retinoids studies]
Gan to kagaku ryoho. Cancer & chemotherapy 1988;15(10):2839-47.
1988: Kagechika H; Hashimoto Y; Kawachi E; Shudo K
Affinity gels for purification of retinoid-specific binding protein (RSBP).
Biochemical and biophysical research communications 1988;155(1):503-8.
1988: Hashimoto Y; Kagechika H; Kawachi E; Shudo K
Specific uptake of retinoids into human promyelocytic leukemia cells HL-60 by retinoid-specific binding protein: possibly the true retinoid receptor.
Japanese journal of cancer research : Gann 1988;79(4):473-83.
1987: Hashimoto Y; Kagechika H; Kawachi E; Shudo K
New-type inducers of differentiation of HL-60 leukemia cells suppress c-myc expression.
Chemical & pharmaceutical bulletin 1987;35(8):3190-4.
1986: Hashimoto Y; Kagechika H; Kawachi E; Shudo K
[Regulation of cell growth by retinoids and gene expression]
Gan to kagaku ryoho. Cancer & chemotherapy 1986;13(12):3392-400.
1986: Kagechika H; Kawachi E; Hashimoto Y; Shudo K
Differentiation inducers of human promyelocytic leukemia cells HL-60. Phenylcarbamoylbenzoic acids and polyene amides.
Chemical & pharmaceutical bulletin 1986;34(5):2275-8.
1985: Kagechika H; Kawachi E; Hashimoto Y; Shudo K
Differentiation inducers of human promyelocytic leukemia cells HL-60. Azobenzenecarboxylic acids and stilbenecarboxylic acids.
Chemical & pharmaceutical bulletin 1985;33(12):5597-600.
1985: Shudo K; Kagechika H; Kawachi E; Hashimoto Y
Chalcone carboxylic acids. Potent differentiation inducers of human promyelocytic cells HL-60.
Chemical & pharmaceutical bulletin 1985;33(1):404-7.
1984: Kagechika H; Kawachi E; Hashimoto Y; Shudo K
New type inducers of differentiation of human HL-60 promyelocytic leukemia cells. Terephthalic anilides.
Chemical & pharmaceutical bulletin 1984;32(10):4209-12.

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